@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1729: (2016-03-28 )
MKQEKVQDLVNQMTLDEKIAQCLQLSPFLFKGTNKNAELTGPLLQEMKLTDAHTENAGSVLGSSSALDMIGIQEAYLKTNRLGIPLVFMADVIHGYKTVFPIPLALGCSFDRETVRVMAEVSALEATADGHHVTFSPMLDLVRDPRWGRVMESTGEDPFLNSELGKAMVDGYQGDASKLDGNFDRMAACVKHFAAYGAAEAGLEYNTVNMSTRELYQNYLPAYHAAIQAGAKLVMTAFNVVDGVPATMNKWLNRDVLRGEMDFDGVLISDWGAVAEVINHGTARNPKEAAQFSMEAGVDLEMMTTCYIHELKGLIEEGKLSESLLDEAVLRMLHLKNDLGLFEDPYRGLKNNDRTKDILTDDSRGKARAAGVESAVLLENKNRLLPLAKETKIALVGPLASSPDILGGWNVYGEEKDGINVETGLREVFETVEVISTEYTEFSDEDKVAVKAAVQNMDVVVLALGEKNEWGGEAGSLATIRLPEAQYELAKFVQTLEKPVVITLFNGRPLEVKELAESSDALLELWFPGTEAGRVTADLLSGASNPSGKLSMSFPQTTGQIPVYYNHLRTGRPQTPENKGERYVSHYLDIPNEPFYPFGYGKSYSEFELKTSSLPKELNLGEPLHVEVTIKNISDIAGKEVIQVYLQDVTASISRPVKELKAFEKVALQAGEEKTVTFELTSEAFSFYNHQLEKVQEPGLHRIFVGTSSEDVDAFELEVGGYV
Atome Classification :
(20 SA)
.........10........20.....-...30........40........50.-.......60..-.----.-------..----..70.........80.....--...90.....--------------.-----..100.......110.......120.......130.......140.......150.......160.......170......-------.----180.......190.......200.......210.......220......-.230.-......240.......250.......260-.......270.......280.......290.......300.....---------.---.310...-....320.......330....-.------..340.......350.......360.......370.......380-----.-----.....-.390........400..-..-....410----------..-----......-.420.......---430-..--------------....---------------.-..440-----------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------.-.-.-...---------------------..450..---.....460.......470.....-.----.480.......490.----..----....500.......510.......520.......530.......540.......550.......560..-.-....570.-......580--....--....590........600.....---..--610.......-620-.........630...-....640.......650.......660.....-..670.......680.-......690........700.......710.-.-.....720.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
Q
E
K
V
Q
D
L
V
N
Q
M
T
L
D
E
K
I
A
Q
C
L
QLS-
P
F
L
FKGTNKNAEL
T
G
P
L
L
Q
E
MKLTDA-HTENAGSVLGS-S----S-------AL----
D
M
I-
G
I
Q
E
A
Y
L
KTNRLG
I
P
L
--
V
F
M
A
D
V
I
HGY--------------K-----
T
V
F
P
I
P
L
A
LGCSF
D
R
E
T
V
R
V
M
A
E
V
S
A
L
EATADG
H
H
V
T
F
S
P
M
L
D
L
VRDPRW
G
R
V
M
ESTGEDPF
L
N
S
E
L
G
K
A
M
V
DGYQG
D
A
S
K-------L----DG
N
F
D
R
M
A
A
C
V
K
H
F
A
A
YGAAEAG
L
E
Y
NTVN
M
S
T
R
E
L
Y
Q
N
Y
L
P
A
Y
H
A
A
I
Q
-A
G
A
K
L
-
V
M
T
A
F
N
VVDGV
P
A
T
M
N
K
W
L
N
R
D
V
LRGEMD-FD
G
V
L
IS
D
W
G
A
V
A
E
V
I
NHGTAR
N
P
K
E
A
A
Q
F
S
MEAGVD
L
E
M
M
T
T
C
Y
---------
I
---
H
E
L
K
G
L
I
-
E
EG
K
L
S
E
S
L
L
D
E
A
V
L
R
M
L
H
LK-N------DLGLFED
P
Y
RGLKNNDRTKDILTDDSRGKARAAGV
E
S
A
V
L
LENKN-----R-----LLPLA-KE
T
-
K
I
A
L
VGPLAS-SP-DI-LGGWN------------VY-----GEEKDG-I
N
V
E
T
G
L
R
E
V
F
---
E
---
T
V
--------------
E
V
I
S
---------------
T
-
E
YT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--------------------F-S-D-E
D
K
---------------------
V
A
V
K
A
A
V---QNM
D
V
V
V
L
A
LGEKNEWGGEAG
S
L
-
A
----
T
I
RLP
E
A
Q
Y
E
L
A
K
F
V
----
Q
T
----LEK
P
V
V
I
T
L
FNGRP
L
E
V
K
E
L
AESSD
A
L
L
E
L
WFPGTEA
G
R
V
T
A
D
L
L
SGASNPSG
K
L
S
M
SFPQTTGQ
I
P
V
Y
-
Y
-NHLRTGRP-QTPE
N
K
G
E
---
R
Y
V
S
--
H
Y
LDI-PNEPFYPFGYGKSY
S
E
F
---
E
L
--KTSSLPKELN-L---GE
P
L
H
V
E
V
T
I
K
N
I
S
D
-
I
A
G
K
E
V
I
Q
V
Y
L
Q
D
V
T
A
S
I
S
R
P
V
K
E
L
K
A
F
E
K
V
A
-
L
QAGEE
K
T
V
T
F
E
L
T
S
E
-
A
F
S
F
Y
N
H
Q
-
L
E
K
VQEPGL
H
R
I
F
VGTSSED
V
D
-
A
-
F
E
L
EVGGYV
29
HHSearch
93.77
42%
-66
- C2 -
3U48
2
?
A:
[3-730]
-
M
N
Q
F
I
N
A
L
M
A
K
M
T
L
D
E
K
I
G
Q
L
N
L
P
G
-
A
G
D
I
T
T
-
G
Q
--------
A
S
S
S
G
I
A
Q
K
I
K
E
G
K
V
G
G
L
F
N
I
-
K
----
S
-------
V
T
----
K
I
K
-
E
V
Q
R
I
A
V
E
E
S
R
L
K
I
P
L
--
L
F
G
M
D
V
I
H
G
Y
--------------
E
-----
T
A
F
P
I
P
L
G
L
S
C
T
W
D
M
E
L
I
E
K
S
A
R
I
A
A
I
E
A
S
A
D
G
I
C
W
T
F
S
P
M
V
D
I
S
R
D
P
R
W
G
R
V
S
E
G
S
G
E
D
P
Y
L
G
A
Q
I
A
K
A
M
V
K
G
Y
Q
G
K
D
---------
F
----
S
-
D
N
T
S
I
M
A
C
V
K
H
F
A
L
Y
G
A
G
E
A
G
R
D
Y
N
T
V
D
M
S
R
V
R
M
Y
N
E
Y
F
P
P
Y
K
A
A
V
D
-
A
G
V
G
S
-
V
M
T
S
F
N
E
I
D
G
I
P
A
T
G
N
K
W
L
M
T
D
V
L
R
K
R
I
G
A
F
K
G
F
V
V
T
D
Y
T
A
I
N
E
M
I
D
H
G
M
-
G
D
L
Q
T
V
S
A
L
A
L
R
A
G
V
D
M
D
M
V
G
E
G
F
---------
L
---
T
T
L
K
K
S
L
-
Q
E
G
K
I
T
Q
A
Q
I
D
A
A
C
K
R
I
L
E
A
K
-
Y
------
K
L
G
L
F
S
D
P
Y
K
Y
C
N
E
E
R
A
R
T
Q
I
F
T
P
E
H
R
K
I
A
R
E
I
A
A
Q
S
F
V
L
L
K
N
D
N
-----
N
-----
V
L
P
L
K
-
K
S
G
-
T
I
A
L
V
G
P
L
A
D
N
R
V
-
N
M
-
P
G
T
W
S
------------
V
A
-----
A
K
H
A
E
S
-
V
S
L
L
E
G
L
K
K
A
A
GND
A
---
R
I
--------------
L
Y
A
H
---------------
G
S
N
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
K
S
L
I
E
R
A
T
MFGKTLKYDPR
P
-
K
-
D
V
V
I
K
---------------------
E
A
V
D
I
-
A
---
N
Q
A
D
V
I
V
A
A
L
G
E
S
A
E
M
S
G
E
A
S
S
R
-
S
----
N
I
E
I
P
A
L
Q
R
E
L
L
Q
A
L
----
L
K
----
T
G
K
P
V
V
L
V
L
F
T
G
R
P
L
A
L
T
W
E
H
E
N
V
P
A
I
L
N
V
W
F
A
G
T
E
A
G
D
A
I
S
D
A
L
F
G
V
V
N
P
S
G
K
L
S
A
T
F
P
R
N
V
G
Q
V
P
I
Y
-
Y
-
N
H
K
N
T
G
R
P
----
L
P
E
G
Q
WFQ
K
F
R
S
--
N
Y
L
D
V
-
P
N
D
P
L
Y
P
F
G
Y
G
L
S
F
T
K
F
---
T
Y
--
G
D
L
K
L
S
S
T
N
L
K
G
---
N
Q
T
L
T
A
S
I
E
L
T
N
S
G
D
-
Y
D
G
A
E
V
V
Q
L
Y
I
R
D
L
V
G
S
T
T
R
P
V
K
E
L
K
G
F
Q
K
V
F
-
L
K
K
G
E
T
K
T
I
T
F
K
I
T
P
E
-
D
L
K
F
Y
N
Y
D
-
L
K
Y
D
W
E
P
G
E
F
V
I
M
V
G
G
N
S
R
D
L
K
-
S
----------
22
PsiBlast_CBE
92.49
42%
-66
- C2 -
3U48
2
?
A:
[7-730]
-----
I
N
A
L
M
A
K
M
T
L
D
E
K
I
G
Q
-
L
N
L
--
P
G
A
G
D
I
T
T
G
Q
A
S
S
S
G
-
I
A
Q
K
I
K
------
E
G
K
V
G
G
L
F
N
I
-
K
----
S
-------
V
T
----
K
I
K
-
E
V
Q
R
I
A
V
E
E
S
R
L
K
I
P
L
--
L
F
G
M
D
V
I
H
G
Y
--------------
E
-----
T
A
F
P
I
P
L
G
L
S
C
T
W
D
M
E
L
I
E
K
S
A
R
I
A
A
I
E
A
S
A
D
G
I
C
W
T
F
S
P
M
V
D
I
S
R
D
P
R
W
G
R
V
S
E
G
S
G
E
D
P
Y
L
G
A
Q
I
A
K
A
M
V
K
G
Y
Q
G
---
K
-------
D
----
F
S
D
N
T
S
I
M
A
C
V
K
H
F
A
L
Y
G
A
G
E
A
G
R
D
Y
N
T
V
D
M
S
R
V
R
M
Y
N
E
Y
F
P
P
Y
K
A
A
V
D
-
A
G
V
G
S
-
V
M
T
S
F
N
E
I
D
G
I
P
A
T
G
N
K
W
L
M
T
D
V
L
R
K
R
I
G
A
F
K
G
F
V
V
T
D
Y
T
A
I
N
E
M
I
D
H
G
M
G
-
D
L
Q
T
V
S
A
L
A
L
R
A
G
V
D
M
D
M
V
G
E
G
F
---------
L
---
T
T
L
K
K
S
L
-
Q
E
G
K
I
T
Q
A
Q
I
D
A
A
C
K
R
I
L
E
A
K
-
Y
------
K
L
G
L
F
S
D
P
Y
K
Y
C
N
E
E
R
A
R
T
Q
I
F
T
P
E
H
R
K
I
A
R
E
I
A
A
Q
S
F
V
L
L
K
N
D
N
-----
N
-----
V
L
P
L
K
-
K
S
G
-
T
I
A
L
V
G
P
L
A
D
-
N
R
V
N
M
-
P
G
T
W
S
------------
V
A
-----
A
K
H
A
E
S
-
V
S
L
L
E
G
L
K
K
A
A
---
G
---
N
D
--------------
A
R
I
L
---------------
Y
-
A
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------
N
-
L
-
D
-
E
D
K
S
L
I
E
R
A
T
MFGKTLKYDPRP
K
D
V
V
I
K
E
A
V
D
I
A
N
Q
A
D
V
I
V
A
A
L
G
E
S
A
E
M
S
G
E
A
S
S
R
-
S
----
N
I
E
I
P
A
L
Q
R
E
L
L
Q
A
L
----
L
K
----
T
G
K
P
V
V
L
V
L
F
T
G
R
P
L
A
L
T
W
E
H
E
N
V
P
A
I
L
N
V
W
F
A
G
T
E
A
G
D
A
I
S
D
A
L
F
G
V
V
N
P
S
G
K
L
S
A
T
F
P
R
N
V
G
Q
V
P
I
Y
-
Y
-
N
H
K
N
T
G
R
P
-
L
P
E
G
Q
W
F
Q
---
K
F
R
S
--
N
Y
L
D
V
-
P
N
D
P
L
Y
P
F
G
Y
G
L
S
F
T
K
F
T
Y
G
D
L
--
K
L
S
S
--
T
N
L
K
-
G
---
N
Q
T
L
T
A
S
I
E
L
T
N
S
G
D
-
Y
D
G
A
E
V
V
Q
L
Y
I
R
D
L
V
G
S
T
T
R
P
V
K
E
L
K
G
F
Q
K
V
F
-
L
K
K
G
E
T
K
T
I
T
F
K
I
T
P
E
-
D
L
K
F
Y
N
Y
D
-
L
K
Y
D
W
E
P
G
E
F
V
I
M
V
G
G
N
S
R
D
L
K
-
S
----------
23
PsiBlast_CBE
92.41
42%
-64
- C2 -
3U4A
3
?
B:
[7-730]
-----
I
N
A
L
M
A
K
M
T
L
D
E
K
I
G
Q
-
L
N
L
--
P
G
A
G
D
I
T
T
G
Q
A
S
S
S
G
-
I
A
Q
K
I
K
------
E
G
K
V
G
G
L
F
N
I
-
K
----
S
-------
V
T
----
K
I
K
-
E
V
Q
R
I
A
V
E
E
S
R
L
K
I
P
L
--
L
F
G
M
D
V
I
H
G
Y
--------------
E
-----
T
A
F
P
I
P
L
G
L
S
C
T
W
D
M
E
L
I
E
K
S
A
R
I
A
A
I
E
A
S
A
D
G
I
C
W
T
F
S
P
M
V
D
I
S
R
D
P
R
W
G
R
V
S
E
G
S
G
E
D
P
Y
L
G
A
Q
I
A
K
A
M
V
K
G
Y
Q
G
---
K
-------
D
----
F
S
D
N
T
S
I
M
A
C
V
K
H
F
A
L
Y
G
A
G
E
A
G
R
D
Y
N
T
V
D
M
S
R
V
R
M
Y
N
E
Y
F
P
P
Y
K
A
A
V
D
-
A
G
V
G
S
-
V
M
T
S
F
N
E
I
D
G
I
P
A
T
G
N
K
W
L
M
T
D
V
L
R
K
R
I
G
A
F
K
G
F
V
V
T
N
Y
T
A
I
N
E
M
I
D
H
G
M
G
-
D
L
Q
T
V
S
A
L
A
L
R
A
G
V
D
M
D
M
V
G
E
G
F
---------
L
---
T
T
L
K
K
S
L
-
Q
E
G
K
I
T
Q
A
Q
I
D
A
A
C
K
R
I
L
E
A
K
-
Y
------
K
L
G
L
F
S
D
P
Y
K
Y
C
N
E
E
R
A
R
T
Q
I
F
T
P
E
H
R
K
I
A
R
E
I
A
A
Q
S
F
V
L
L
K
N
D
N
-----
N
-----
V
L
P
L
K
-
K
S
G
-
T
I
A
L
V
G
P
L
A
D
-
N
R
V
N
M
-
P
G
T
W
S
------------
V
A
-----
A
K
H
A
E
S
-
V
S
L
L
E
G
L
K
K
A
A
---
G
---
N
D
--------------
A
R
I
L
---------------
Y
-
A
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------
N
-
L
-
D
-
E
D
K
S
L
I
E
R
A
T
MFGKTLKYDPRP
K
D
V
V
I
K
E
A
V
D
I
A
N
Q
A
D
V
I
V
A
A
L
G
E
S
A
E
M
S
G
E
A
S
S
R
-
S
----
N
I
E
I
P
A
L
Q
R
E
L
L
Q
A
L
----
L
K
----
T
G
K
P
V
V
L
V
L
F
T
G
R
P
L
A
L
T
W
E
H
E
N
V
P
A
I
L
N
V
W
F
A
G
T
E
A
G
D
A
I
S
D
A
L
F
G
V
V
N
P
S
G
K
L
S
A
T
F
P
R
N
V
G
Q
V
P
I
Y
-
Y
-
N
H
K
N
T
G
R
P
-
L
P
E
G
Q
W
F
Q
---
K
F
R
S
--
N
Y
L
D
V
-
P
N
D
P
L
Y
P
F
G
Y
G
L
S
F
T
K
F
T
Y
G
D
L
--
K
L
S
S
--
T
N
L
K
-
G
---
N
Q
T
L
T
A
S
I
E
L
T
N
S
G
D
-
Y
D
G
A
E
V
V
Q
L
Y
I
R
D
L
V
G
S
T
T
R
P
V
K
E
L
K
G
F
Q
K
V
F
-
L
K
K
G
E
T
K
T
I
T
F
K
I
T
P
E
-
D
L
K
F
Y
N
Y
D
-
L
K
Y
D
W
E
P
G
E
F
V
I
M
V
G
G
N
S
R
D
L
K
-
S
----------
24
PsiBlast_CBE
92.21
42%
-65
- C2 -
3U4A
4
?
A:
[7-730]
-----
I
N
A
L
M
A
K
M
T
L
D
E
K
I
G
Q
-
L
N
L
--
P
G
A
G
D
I
T
T
G
Q
A
S
S
S
G
-
I
A
Q
K
I
K
------
E
G
K
V
G
G
L
F
N
I
-
K
----
S
-------
V
T
----
K
I
K
-
E
V
Q
R
I
A
V
E
E
S
R
L
K
I
P
L
--
L
F
G
M
D
V
I
H
G
Y
--------------
E
-----
T
A
F
P
I
P
L
G
L
S
C
T
W
D
M
E
L
I
E
K
S
A
R
I
A
A
I
E
A
S
A
D
G
I
C
W
T
F
S
P
M
V
D
I
S
R
D
P
R
W
G
R
V
S
E
G
S
G
E
D
P
Y
L
G
A
Q
I
A
K
A
M
V
K
G
Y
Q
G
---
K
-------
D
----
F
S
D
N
T
S
I
M
A
C
V
K
H
F
A
L
Y
G
A
G
E
A
G
R
D
Y
N
T
V
D
M
S
R
V
R
M
Y
N
E
Y
F
P
P
Y
K
A
A
V
D
-
A
G
V
G
S
-
V
M
T
S
F
N
E
I
D
G
I
P
A
T
G
N
K
W
L
M
T
D
V
L
R
K
R
I
G
A
F
K
G
F
V
V
T
N
Y
T
A
I
N
E
M
I
D
H
G
M
G
-
D
L
Q
T
V
S
A
L
A
L
R
A
G
V
D
M
D
M
V
G
E
G
F
---------
L
---
T
T
L
K
K
S
L
-
Q
E
G
K
I
T
Q
A
Q
I
D
A
A
C
K
R
I
L
E
A
K
-
Y
------
K
L
G
L
F
S
D
P
Y
K
Y
C
N
E
E
R
A
R
T
Q
I
F
T
P
E
H
R
K
I
A
R
E
I
A
A
Q
S
F
V
L
L
K
N
D
N
-----
N
-----
V
L
P
L
K
-
K
S
G
-
T
I
A
L
V
G
P
L
A
D
-
N
R
V
N
M
-
P
G
T
W
S
------------
V
A
-----
A
K
H
A
E
S
-
V
S
L
L
E
G
L
K
K
A
A
---
G
---
N
D
--------------
A
R
I
L
---------------
Y
-
A
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------
N
-
L
-
D
-
E
D
K
S
L
I
E
R
A
T
MFGKTLKYDPRP
K
D
V
V
I
K
E
A
V
D
I
A
N
Q
A
D
V
I
V
A
A
L
G
E
S
A
E
M
S
G
E
A
S
S
R
-
S
----
N
I
E
I
P
A
L
Q
R
E
L
L
Q
A
L
----
L
K
----
T
G
K
P
V
V
L
V
L
F
T
G
R
P
L
A
L
T
W
E
H
E
N
V
P
A
I
L
N
V
W
F
A
G
T
E
A
G
D
A
I
S
D
A
L
F
G
V
V
N
P
S
G
K
L
S
A
T
F
P
R
N
V
G
Q
V
P
I
Y
-
Y
-
N
H
K
N
T
G
R
P
-
L
P
E
G
Q
W
F
Q
---
K
F
R
S
--
N
Y
L
D
V
-
P
N
D
P
L
Y
P
F
G
Y
G
L
S
F
T
K
F
T
Y
G
D
L
--
K
L
S
S
--
T
N
L
K
-
G
---
N
Q
T
L
T
A
S
I
E
L
T
N
S
G
D
-
Y
D
G
A
E
V
V
Q
L
Y
I
R
D
L
V
G
S
T
T
R
P
V
K
E
L
K
G
F
Q
K
V
F
-
L
K
K
G
E
T
K
T
I
T
F
K
I
T
P
E
-
D
L
K
F
Y
N
Y
D
-
L
K
Y
D
W
E
P
G
E
F
V
I
M
V
G
G
N
S
R
D
L
K
-
S
----------
21
PsiBlast_CBE
91.85
42%
-64
* C2 *
3U48
2
?
B:
[7-730]
-----
I
N
A
L
M
A
K
M
T
L
D
E
K
I
G
Q
-
L
N
L
--
P
G
A
G
D
I
T
T
G
Q
A
S
S
S
G
-
I
A
Q
K
I
K
------
E
G
K
V
G
G
L
F
N
I
-
K
----
S
-------
V
T
----
K
I
K
-
E
V
Q
R
I
A
V
E
E
S
R
L
K
I
P
L
--
L
F
G
M
D
V
I
H
G
Y
--------------
E
-----
T
A
F
P
I
P
L
G
L
S
C
T
W
D
M
E
L
I
E
K
S
A
R
I
A
A
I
E
A
S
A
D
G
I
C
W
T
F
S
P
M
V
D
I
S
R
D
P
R
W
G
R
V
S
E
G
S
G
E
D
P
Y
L
G
A
Q
I
A
K
A
M
V
K
G
Y
Q
G
---
K
-------
D
----
F
S
D
N
T
S
I
M
A
C
V
K
H
F
A
L
Y
G
A
G
E
A
G
R
D
Y
N
T
V
D
M
S
R
V
R
M
Y
N
E
Y
F
P
P
Y
K
A
A
V
D
-
A
G
V
G
S
-
V
M
T
S
F
N
E
I
D
G
I
P
A
T
G
N
K
W
L
M
T
D
V
L
R
K
R
I
G
A
F
K
G
F
V
V
T
D
Y
T
A
I
N
E
M
I
D
H
G
M
G
-
D
L
Q
T
V
S
A
L
A
L
R
A
G
V
D
M
D
M
V
G
E
G
F
---------
L
---
T
T
L
K
K
S
L
-
Q
E
G
K
I
T
Q
A
Q
I
D
A
A
C
K
R
I
L
E
A
K
-
Y
------
K
L
G
L
F
S
D
P
Y
K
Y
C
N
E
E
R
A
R
T
Q
I
F
T
P
E
H
R
K
I
A
R
E
I
A
A
Q
S
F
V
L
L
K
N
D
N
-----
N
-----
V
L
P
L
K
-
K
S
G
-
T
I
A
L
V
G
P
L
A
D
-
N
R
V
N
M
-
P
G
T
W
S
------------
V
A
-----
A
K
H
A
E
S
-
V
S
L
L
E
G
L
K
K
A
A
---
G
---
N
D
--------------
A
R
I
L
---------------
Y
-
A
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------
N
-
L
-
D
-
E
D
K
S
L
I
E
R
A
T
MFGKTLKYDPRP
K
D
V
V
I
K
E
A
V
D
I
A
N
Q
A
D
V
I
V
A
A
L
G
E
S
A
E
M
S
G
E
A
S
S
R
-
S
----
N
I
E
I
P
A
L
Q
R
E
L
L
Q
A
L
----
L
K
----
T
G
K
P
V
V
L
V
L
F
T
G
R
P
L
A
L
T
W
E
H
E
N
V
P
A
I
L
N
V
W
F
A
G
T
E
A
G
D
A
I
S
D
A
L
F
G
V
V
N
P
S
G
K
L
S
A
T
F
P
R
N
V
G
Q
V
P
I
Y
-
Y
-
N
H
K
N
T
G
R
P
-
L
P
E
G
Q
W
F
Q
---
K
F
R
S
--
N
Y
L
D
V
-
P
N
D
P
L
Y
P
F
G
Y
G
L
S
F
T
K
F
T
Y
G
D
L
--
K
L
S
S
--
T
N
L
K
-
G
---
N
Q
T
L
T
A
S
I
E
L
T
N
S
G
D
-
Y
D
G
A
E
V
V
Q
L
Y
I
R
D
L
V
G
S
T
T
R
P
V
K
E
L
K
G
F
Q
K
V
F
-
L
K
K
G
E
T
K
T
I
T
F
K
I
T
P
E
-
D
L
K
F
Y
N
Y
D
-
L
K
Y
D
W
E
P
G
E
F
V
I
M
V
G
G
N
S
R
D
L
K
-
S
----------
30
HHSearch
77.23
31%
-58
- C2 -
3ABZ
4
?
A:
[2-836]
-
S
K
F
D
V
E
Q
L
L
S
E
L
N
Q
D
E
K
I
S
L
L
S
A
V
D
-
F
W
H
T
----------------------------
K
K
I
------------------------------------
E
R
L
G
I
P
A
--
V
R
V
S
D
G
P
N
G
I
RGTKFFDGV
P
----
S
-----
G
C
F
P
N
G
T
G
L
A
S
T
F
D
R
D
L
L
E
T
A
G
K
L
M
A
K
E
S
I
A
K
N
A
A
V
I
L
G
P
T
T
N
M
Q
R
G
P
L
G
G
R
G
F
E
S
F
S
E
D
P
Y
L
A
G
M
A
T
S
S
V
V
K
G
M
Q
G
--------------------
E
G
I
A
A
T
V
K
H
F
V
C
N
D
L
E
D
-
Q
R
F
S
S
N
S
I
V
S
E
R
A
L
R
E
I
Y
L
E
P
F
R
L
A
V
K
H
A
N
P
V
C
-
I
M
T
A
Y
N
K
V
N
G
E
H
C
S
Q
S
K
K
L
L
I
D
I
L
R
D
E
W
K
-
W
D
G
M
L
M
S
D
W
F
G
T
Y
T
-------------
T
A
A
A
I
K
N
G
L
D
I
E
F
P
G
P
T
R
---------
W
RT
R
A
L
V
S
H
S
L
N
S
R
E
Q
I
T
T
E
D
V
D
D
R
V
R
Q
V
L
K
M
I
K
F
V
V
D
N
L
E
K
T
G
I
V
E
N
G
P
E
-------
S
T
S
N
N
T
K
E
T
S
D
L
L
R
K
I
A
A
D
S
I
V
L
L
K
N
K
N
-----
N
-----
I
L
P
L
K
-
K
E
D
-
N
I
I
V
I
G
P
N
A
K
-
A
K
-
T
S
-
S
G
G
G
S
------------
A
S
-----
M
N
S
Y
Y
V
-
V
S
P
Y
E
G
I
V
N
K
L
---
G
K
--
E
V
--------------
D
Y
T
V
---------------
G
A
Y
S
H
KSIGGLAESSLIDAAKPADAEN
S
G
L
I
A
K
F
Y
SNPVEERSDDEEPF
H
V
T
K
V
NRSNVHLFDFKHEKVDPKNP
Y
F
F
V
T
L
T
G
Q
Y
V
P
Q
E
D
G
D
Y
I
F
S
L
Q
V
Y
G
S
G
L
F
Y
L
NDELIIDQKHN
Q
E
R
G
SFCFGAGT
K
E
R
T
K
K
L
T
L
K
K
G
Q
V
Y
N
V
R
V
E
Y
G
S
GPTSGLVGEFGA
G
G
F
Q
A
G
V
I
K
A
I
--------------------
D
-
D
-
D
E
E
I
R
---------------------
N
A
A
E
L
-
A
---
A
K
H
D
K
A
V
L
I
I
G
L
N
G
E
W
E
T
E
G
Y
D
R
-
E
----
N
M
D
L
P
K
R
T
N
E
L
V
R
A
V
----
L
K
----
A
N
P
N
T
V
I
V
N
Q
S
G
T
P
V
E
F
P
W
L
E
-
D
A
N
A
L
V
Q
A
W
Y
G
G
N
E
L
G
N
A
I
A
D
V
L
Y
G
D
V
V
P
N
G
K
L
S
L
S
W
P
F
K
L
Q
D
N
P
A
F
-
L
-
N
F
K
T
E
F
G
--
R
V
I
Y
G
E
D
I
---
F
V
G
Y
--
R
Y
Y
E
K
L
Q
R
K
V
A
F
P
F
G
Y
G
L
S
Y
T
T
F
---
E
L
D
I
S
D
F
K
V
T
---------
D
D
K
I
A
I
S
V
D
V
K
N
T
G
D
K
F
A
G
S
E
V
V
Q
V
Y
F
S
A
L
N
S
K
V
S
R
P
V
K
E
L
K
G
F
E
K
V
H
-
L
E
P
G
E
K
K
T
V
N
I
D
L
E
L
K
D
A
I
S
Y
F
N
E
E
L
G
K
W
H
V
E
A
G
E
Y
L
V
S
V
G
T
S
S
D
D
I
L
-
S
V
K
E
F
K
V
----
32
HHSearch
76.01
31%
-67
- C2 -
3WLI
20
?
A:
[16-606]
-
V
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
------------------
T
P
D
V
L
R
D
N
F
I
G
S
L
L
S
G
G
G
SVPR
K
GAT
A
K
E
W
Q
D
----
M
V
D
-
G
F
Q
K
A
C
M
S
-
T
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
NNVYG---------
A
-----
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
-
E
L
I
P
G
L
Q
G
D
V
P
K
DFTS---
G
M
P
F
V
A
G
-
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
D
R
I
T
-
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
A
D
P
A
M
---
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
TSTDA
P
-----
L
L
P
L
P
K
K
A
P
-
K
I
L
V
A
G
S
H
A
D
N
L
G
-
Y
Q
-
C
G
G
W
T
------------
I
E
WQGDT
G
R
T
T
V
G
-
T
T
I
L
E
A
V
K
A
A
V
---
D
PS
T
V
V
--------------
V
F
A
E
---------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
A
---------------------
E
F
V
-
K
-
S
---
G
G
F
S
Y
A
I
V
A
V
G
E
H
P
Y
T
E
T
-
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
-----
G
V
R
C
A
T
V
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
-
G
Q
G
V
T
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
N
-
V
-
G
----------------------
D
--
A
H
Y
-----
D
P
L
F
R
L
G
Y
G
L
T
T
N
A
T
-----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.27
29%
-62
- C2 -
1IEW
3
?
A:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.17
29%
-62
- C2 -
3WLI
19
?
A:
[17-600]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.13
29%
-63
- C2 -
3WLK
11
?
X:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
KEWQ
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSGMP
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
QQF------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.06
29%
-63
- C2 -
3WLJ
9
?
A:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.06
29%
-62
- C2 -
3WLO
5
?
A:
[17-600]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.03
29%
-62
- C2 -
3WLH
9
?
A:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.95
29%
-63
- C2 -
3WLL
11
?
A:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.87
29%
-61
- C2 -
1IEV
4
?
A:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.82
28%
-48
- C2 -
2X41
5
?
A:
[2-705]
---
E
K
V
N
E
I
L
S
Q
L
T
L
E
E
K
V
K
L
V
V
G
V
G
L
P
G
L
F
-------------------
G
N
P
-
H
S
R
V
A
G
A
A
-
G
E
-
T
----
H
-------
P
V
----
P
R
V
-
G
L
P
A
F
V
L
A
D
G
P
A
G
L
R
I
NP
T
R
E
N
D
E
N
T
Y
Y
--------------
T
-----
T
A
F
P
V
E
I
M
L
A
S
T
W
N
R
E
L
L
E
E
V
G
K
A
M
G
E
E
V
R
E
Y
G
V
D
V
L
L
A
P
A
M
N
I
H
R
N
P
L
C
G
R
N
F
E
Y
Y
S
E
D
P
V
L
S
G
E
M
A
S
S
F
V
K
G
V
Q
S
Q
G
--------------------
V
G
A
C
I
K
H
F
V
A
N
N
Q
E
T
N
R
M
V
V
D
T
I
-
V
S
E
R
A
L
R
E
I
Y
L
R
G
F
E
I
A
V
K
-
K
S
K
P
W
S
V
M
S
A
Y
N
K
L
N
G
K
Y
C
S
Q
N
E
W
L
L
K
K
V
L
R
E
E
W
G
-
F
E
G
F
V
M
S
D
W
Y
A
---------
G
D
N
P
V
E
----
Q
L
K
A
G
N
D
L
I
M
P
G
K
A
Y
QVNTERRD
E
I
---
E
E
I
M
E
A
L
-
K
E
G
K
L
S
E
E
V
L
D
E
C
V
R
N
I
L
K
V
L
-
V
------
N
A
P
S
F
K
N
-
Y
R
Y
S
N
K
P
D
L
E
K
H
A
K
V
------
A
Y
E
A
G
A
E
G
V
V
L
L
R
N
E
------
E
-----
A
L
P
L
S
-
E
N
S
-
K
I
A
L
F
G
-
T
G
Q
-
I
E
-
T
I
-
K
G
G
T
G
SG
D
T
H
P
R
Y
A
I
S
I
L
E
-----
G
I
K
E
R
G
-
L
N
F
D
E
E
L
A
K
T
Y
---
E
---
D
Y
I
K
K
M
R
E
TEEYKPRR-
I
I
K
---------------
P
-
K
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------
N
-
F
-
L
-
S
E
K
---------------------
E
I
H
K
L
A
K
---
K
N
-
D
V
A
V
I
V
I
S
R
I
S
G
E
G
Y
D
R
K
P
V
K
G
----
D
F
Y
L
S
D
D
E
T
D
L
I
K
T
V
S
R
E
F
H
E
----
Q
G
K
K
V
I
V
L
L
N
I
G
S
P
V
E
V
V
S
W
R
D
L
V
D
G
I
L
L
V
W
Q
A
G
Q
E
T
G
R
I
V
A
D
V
L
T
G
R
I
N
P
S
G
K
L
P
T
T
F
P
R
D
Y
S
D
V
P
S
W
T
F
-
P
G
E
P
K
D
N
P
-
Q
K
V
V
Y
E
E
D
---
I
Y
V
G
Y
R
Y
Y
D
T
F
-
G
V
E
P
A
Y
E
F
G
Y
G
L
S
Y
T
T
F
---
E
Y
--------
S
D
L
N
-
V
S
F
D
G
E
T
L
R
V
Q
Y
R
I
E
N
T
G
G
-
R
A
G
K
E
V
S
Q
V
Y
I
K
A
P
K
G
K
I
D
K
P
F
Q
E
L
K
A
F
H
K
T
R
L
L
N
P
G
E
S
E
E
V
V
L
E
I
P
V
R
-
D
L
A
S
F
N
G
E
--
E
W
V
V
E
A
G
E
Y
E
V
R
V
G
A
S
S
R
N
I
-------------
18
PsiBlast_PDB
74.70
29%
-63
- C2 -
3WLN
3
?
A:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.65
29%
-62
- C2 -
3WLP
13
?
A:
[13-596]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
G
Q
M
T
Q
I
E
-
R
L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
G
F
Q
K
A
C
M
S
T
-
R
L
G
I
P
M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
A
T
R
D
P
Y
L
V
K
R
I
G
E
A
T
A
L
E
V
R
A
T
G
I
Q
Y
A
F
A
P
C
I
A
V
C
R
D
P
R
W
G
R
C
Y
E
S
Y
S
E
D
R
R
I
V
Q
S
M
T
E
-
L
I
P
G
L
Q
G
D
V
P
K
DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
F
V
G
D
G
G
T
V
D
G
I
N
E
N
N
T
I
I
N
R
E
G
L
M
N
I
H
M
P
A
Y
K
N
A
M
D
-
K
G
V
S
T
-
V
M
I
S
Y
S
S
W
N
G
V
K
M
H
A
N
Q
D
L
V
T
G
Y
L
K
D
T
L
K
-
F
K
G
F
V
I
S
D
W
E
G
I
-
D
R
I
T
T
P
A
G
S
D
Y
S
Y
S
V
K
A
S
I
L
A
G
L
D
M
I
M
V
P
N
K
Y
Q
Q
F
------
I
---
S
I
L
T
G
H
V
-
N
G
G
V
I
P
M
S
R
I
D
D
A
V
T
R
I
L
R
V
K
-
F
------
T
M
G
L
F
E
N
P
Y
---
A
D
P
A
M
A
E
Q
L
G
K
Q
E
H
R
D
L
A
R
E
A
A
R
K
S
L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
P
L
P
-
K
K
A
P
K
I
L
V
A
G
S
H
A
D
-
N
L
-
G
Y
Q
C
G
G
W
T
------------
I
E
-----
W
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
E
T
K
G
D
N
-
L
----
N
L
T
I
P
E
P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
V
-
L
I
S
G
R
P
V
V
V
Q
P
L
L
A
A
S
D
A
L
V
A
A
W
L
P
G
S
E
G
Q
G
V
T
-
D
A
L
F
G
D
F
G
F
T
G
R
L
P
R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
74.54
31%
-56
- C2 -
2X41
5
?
A:
[2-715]
---
E
K
V
N
E
I
L
S
Q
L
T
L
E
E
K
V
K
L
V
V
G
V
G
-
L
P
G
L
F
--
G
N
------------------
P
H
S
R
V
A
G
A
-----------------
A
G
----
E
T
H
-
P
-------
V
P
R
V
G
L
P
A
--
F
V
L
A
D
G
P
A
G
L
RINPTRENDENTY
Y
T
-----
T
A
F
P
V
E
I
M
L
A
S
T
W
N
R
E
L
L
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Y
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L
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M
A
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S
F
V
K
G
V
Q
S
--------------------
Q
G
V
G
A
C
I
K
H
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V
A
N
N
Q
E
T
-
N
R
M
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Y
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K
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E
E
W
G
-
F
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G
F
V
M
S
D
W
Y
A
G
-------------
D
N
P
V
E
Q
L
K
A
G
N
D
L
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K
A
Y
QVNTERRD
E
I
---
E
E
I
M
E
A
L
-
K
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G
K
L
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E
E
V
L
D
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C
V
R
N
I
L
K
V
L
-
V
------
N
A
P
S
F
K
N
Y
R
Y
-------
S
N
K
P
D
L
E
K
H
A
K
V
A
Y
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A
G
A
E
G
V
V
L
L
R
N
E
------
E
-----
A
L
P
L
S
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N
-
S
-
K
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T
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-
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K
-
G
G
T
G
S
------------
G
D
-----
T
H
P
R
Y
A
-
I
S
I
L
E
G
I
K
E
R
G
---
L
---
N
F
D
E
E
L
A
K
--------
T
Y
E
D
Y
I
K
K
M
R
E
TEEYKPRR--
I
I
K
P------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------
L
P
E
N
F
L
S
E
K
---------------------
E
I
H
K
L
-
A
---
K
K
N
D
V
A
V
I
V
I
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R
I
---
S
G
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G
Y
D
R
-
K
PVKG
D
F
Y
L
S
D
D
E
T
D
L
I
K
T
V
----
S
R
E
F
H
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Q
G
K
K
V
I
V
L
L
N
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W
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W
-
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V
V
Y
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I
---
Y
V
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Y
--
R
Y
Y
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L
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Y
T
T
F
---
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Y
--
S
D
L
N
V
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-------
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--
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N
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L
K
-
G
T
F
S
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G
E
--
4
PsiBlast_PDB
74.49
29%
-62
- C2 -
3WLT
18
?
A:
[17-600]
--
E
D
R
V
A
D
L
L
G
R
M
T
L
A
E
K
I
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Q
M
T
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I
E
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L
V
A
T
P
D
V
L
R
D
N
F
I
G
S
L
L
-----------
S
G
G
G
S
V
P
R
K
-
G
----
A
-------
T
A
K
E
W
Q
D
M
V
D
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K
A
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M
S
T
-
R
L
G
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M
--
I
Y
G
I
D
A
V
H
G
Q
--------------
N
NVYGA
T
I
F
P
H
N
V
G
L
G
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D
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L
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D
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P
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DFTSG
M
P
F
----
V
A
G
K
N
K
V
A
A
C
A
K
H
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G
D
G
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P
N
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Y
Q
Q
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---
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-
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G
G
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------
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M
G
L
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Y
---
A
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L
A
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A
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K
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L
V
L
L
K
N
G
K
-----
T
STDAP
L
L
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L
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-
K
K
A
P
K
I
L
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A
G
S
H
A
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-
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L
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Y
Q
C
G
G
W
T
------------
I
E
-----
A
Q
G
D
T
G
R
T
T
V
G
T
T
I
L
E
A
V
---
K
---
A
A
--------------
V
D
P
S
---------------
T
-
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------
A
-
E
-
N
-
P
D
A
---------------------
E
F
V
K
S
G
-----
G
F
S
Y
A
I
V
A
V
G
E
-
H
P
Y
T
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T
K
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D
N
-
L
----
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L
T
I
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P
G
L
S
T
V
Q
A
V
----
C
G
----
G
V
R
C
A
T
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-
L
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R
L
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R
T
W
F
K
S
V
D
Q
L
P
M
-----------------
N
V
G
D
------
A
--
H
Y
------
D
P
L
F
R
L
G
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------