@TOME V2.3
(Nov 2016)

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3D Common Core:

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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : Lmo1757: (2016-03-28 )
MKKLIIAALGLTLVLSGCAPKLDSNDKVVQKDDSKAETGIMTKNQISSNYYKTVLPYKASKSRGLVVSNIYSRYDINELESGLMRVSQNKYSPDNYLFQEGQYLDKETLEKWLDRKSDKNPNGLNPASNGNGENRKPIYLAHILEQDYLKQTDKDTVALGGISIALAMNSVDYYQKEKYGDTYEQPISDSELLAQGKEMSATVLNRIRQTKGLENVPVTIAIYKQGARDAVAPGNYIAYATANGDSLSNWKDIDEKNYVLPSTESAKDHKTDNDNFLNFKKAIEDYYPNFTGVVGRGRYEDGQLAELNIDIPLQFYGEAEIIGFTQYVTDLVGQHIPKTADLQVNISTSDGPAALITRKANEDAATAHIYD

Atome Classification :

(20 SA) -----------------------------------.........10....------------....20--------.........30.-----...--.-...40........--50...------..---...60..--...-..-.------70---------------..---------.......80........90-----------........100.--....---..--------110....-----------------.-----------------..----------------120-.--------..-....130-----.--.-----..-----...140------.---...---....150--....-....--160.....-------.-.170--------......--...180---.......190-....-..-...200.--......-210....-------...220..-------------------...--..230...-------..----.--------.240--.-...--.-..--------250-----.......260..---------....-.270...----...--.280..----....-.290.......300......-------.310------.----...---.-----...320.-----......-----330-----------------------------------------------.........340-.........350..-----....--.--.360.......370---------------------------------------------------
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) -----------------------------------MKKLIIAALGLTLVL------------SGCAP---------KLDSNDKVVQKD-----DSK--A-ETGIMTKNQISSN--YYKTV------LP---YKASKSR--GLV-VS-N------I----------------YS---------RYDINELESGLMRVSQNKY-----------SPDNYLFQEGQY--LDKE---TL--------EKWLDRK-----------------S-----------------DK----------------NPN-G--------LN-PASNGNG-----E--N-----RK-----PIYLA-------H---ILE---QDYLKQ---TDKD-TVAL--GGISIALA-------M-NS----------VDYYQK--EKYGDT---YEQPISDS---ELLA-QG-KEMSATV--LNRIRQ-TKGLENV-------PVTIAIYK-------------------QGA--RDAVAPGN-------YI----A--------YATA--N-GDS--L-SN--------WKD-----IDEKNYVLPSTE---------SAKD-HKTDNDN----FLN--FKKAIE----DYYP-NFTGVVGRGRYEDGQLAELN-------IDI-------P----LQF---Y-----GEAEIIG-----FTQYVT-----D-------------------------------------------------LVGQHIPKTA---DLQVNISTSDG-PA-----ALIT--R--KANEDAATAHIYD----------------------------------------------------
1 PsiBlast_PDB 100.0098% -76 - C4 -4HN3 ? A:[19-350] -------------------------------------------------------------------------------------------------------IMTKNQISSN--YYKTV------LP---YKASKSR--GLV-VS-N------I----------------YS---------RYDINELESGLMRVSQNKY-----------SPDNYLFQEGQY--LDKE---TL--------EKWLDRK-----------------S-----------------DK----------------NPN-G--------LN-PASNGNG-----E--N-----RK-----PIYLA-------H---ILE---QDYLKQ---TDKD-TVAL--GGISIALA-------M-NS----------VDYYQK--EKYGDT---YEQPISDS---ELLA-QG-KEMSATV--LNRIRQ-TKGLENV-------PVTIAIYK-------------------QGA--RDAVAPGN-------YI----A--------YATA--N-GDS--L-SN--------WKD-----IDEKNYVLPSTE---------SAKD-HKTDNDN----FLN--FKKAIE----DYYP-NFTGVVGRGRYEDGQLAELN-------IDI-------P----LQF---Y-----GEAEIIG-----FTQYVT-----D-------------------------------------------------LVGQHIPKTA---DLQVNISTSDG-PA-----ALIT--R--KANEDAATAHIYD----------------------------------------------------
2 PsiBlast_PDB 82.4038% -66 - C4 -3IB5 ? A:[7-345] ------------------------------------------------------------------------------------------------------GYQTTGENNSS--DYQGI------IEDGEYKTSKSR--GVG-ISQN------S----------------DN---------LLNLKSFEAGLTTISKDHF-----------STKSYIFQEGQY--LNKA---TI--------QDWLGRK-----------------S-----------------SS----------------NPE-G--------LN-PSDNGKK-----EANK-----RN-----PIYVQ-------Q---IEE---QDYMKQ---NN-G-KLEL--AGMTIGIG-------M-NQ----------KDYYQK--EQYGAT---YSTTISKE---KRIE-EG-KIAAKKV--LARVRQ-KVG-NNV-------PIVIAMFA-------------------QAP--NDSLVGGY-------FY----S--------YTVSK-S-GTD--I-GS--------WTE-----TNIKSYVLPATE------------D-NKLPNDNDSTSFDN--FQKEVK----NFFP-NISNVTGQGQYKDKTLQGLH-------ITI-------T----TQF---Y-----SETEITS-----FTQYVA-----Q-------------------------------------------------AAKSYLPSGI---PVDIKINGSDG-ETQ----SFVS--T--TGGNGGYYTHVF-----------------------------------------------------
21 HHSearch 80.9038% -61 - C4 -3IB5 ? A:[7-346] ------------------------------------------------------------------------------------------------------GYQTTGENNSS--DYQGI------IEDGEYKTSKSR--GVG-IS-Q------NS---------------DN---------LLNLKSFEAGLTTISKDHF-----------STKSYIFQEGQY--LNKA---TI--------QDWLGRK-----------------S-----------------SS----------------NPE-G--------LN-PSDNGKK-----E--ANK---RN-----PIYVQ-------Q---IEE---QDYMKQ---NNGK--LEL--AGMTIGIG-------M-NQ----------KDYYQK--EQYGAT---YSTTISKE---KRIE-EG-KIAAKKV--LARVRQ-KV-GNNV-------PIVIAMFA-------------------QAP--NDSLVGGY-------FY----S--------YTVS--KSGTD--I-GS--------WTE-----TNIKSYVLPATE---------DNKLPNDNDSTS----FDN--FQKEVK----NFFP-NISNVTGQGQYKDKTLQGLH-------ITI-------T----TQF---Y-----SETEITS-----FTQYVA-----Q-------------------------------------------------AAKSYLPSGI---PVDIKINGSDGETQ-----SFVS--T--TGGNGGYYTHVFG----------------------------------------------------
22 HHSearch 79.0938% -68 * C4 *2QX2 ? A:[13-343] ---------------------------------------------------------------------------------------------------------------------------------------------LL-QD-N------M----------------AN---------SYNGGDFEDGLLNLSKEVF-----------PTDKYLYQDGQF--LDKK---TI--------NAYLNPK-----------------YTKREIDKMSEKDKKDKKAN----------------ENL-G--------LN-PSHEGET-----N--PEKIAEKS-----PAYLS-------N---ILE---QDFYG----------KNI--KGMTIGLA-------M-NS----------VYYYKK--EKDGPT---FSKKLDDS---EVKK-QG-KQMASEI--LSRLRE-NDDLKDI-------PIHFAIYK-------------------QSS--EDSITPGE-------FI----T--------QATA--EKSQT--KL-E--------WHN-----INEKSALLPSST---------AADY-DENLNNN----FKQ--FNDNLQ------------QAVGKVKFVDKKPQRLV-------VDL-------P----IDY---Y-----GQAETIG-----ITQYVT-----E-------------------------------------------------QANKYFDKID---NYEIRIKDGNQ-PR-----ALIS--K--TKDDKEPQVHIYS----------------------------------------------------
3 PsiBlast_PDB 79.0035% -73 - C4 -2QX2 ? A:[13-342] ---------------------------------------------------------------------------------------------------------------------------------------------LL-QD-N------M----------------AN---------SYNGGDFEDGLLNLSKEVF-----------PTDKYLYQDGQF--LDKK---TI--------NAYLNPK-----------------Y-----------------TKREIDKMSEKDKKDKKANENLG--------LN-PSHEGET-----N--P-----EKIAEKSPAYLS-------N---ILE---QDFYG----------KNI--KGMTIGLA-------M-NS----------VYYYKK--EKDGPT---FSKKLDDS---EVKK-QG-KQMASEI--LSRLRE-NDDLKDI-------PIHFAIYK-------------------QSS--EDSITPGE-------FI----T--------QATA--E-KSQTKL--E--------WHN-----INEKSALLPSST---------AADY-DENLNNN----FKQ--FNDNLQ------------QAVGKVKFVDKKPQRLV-------VDL-------P----IDY---Y-----GQAETIG-----ITQYVT-----E-------------------------------------------------QANKYFDKID---NYEIRIKDGNQ-PR-----ALIS--K--TKDDKEPQVHIY-----------------------------------------------------
35 Fugue 75.8135% -55 - C4 -2QX2 ? A:[13-344] ----------------------------------------------------------------------------------------------------------------------------------------------L-LQ-D------NM---------------AN---------SYNGGDFEDGLLNLSKEVF-----------PTDKYLYQDGQF--LDKK---TI--------NAYLNPKYTKREIDKMSEKDKKDKK-----------------AN----------------ENL-G--------LN-PSHEGETNPEKIA--E-----KS-----PAYLS-------N---ILE---QDFYGK---NIKGMTIGL--A---------------MNS----------VYYYKK--EKDGPT---FSKKLDDS---EVKK-QG-KQMASEI--LSRLRE-NDDLKDI-------PIHFAIYK-------------------QSS--EDSITPGE-------FI----T--------QATA--EKSQT--K-LE--------WHN-----INEKSALLPS-----------------STAADY----DEN--LNNNFK----QFND-NLQQAVGKVKFVDKKPQRLV-------VDL-------P----IDY---Y-----GQAETIG-----ITQYVT-----E-------------------------------------------------QANKYFDKID---NYEIRIKDGNQ-PR-----ALIS--K--TKDDKEPQVHIYSN---------------------------------------------------
4 PsiBlast_PDB 53.3526% -12 - C4 -3N2Q - ? A:[73-333] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------S---------KLDLAEYENGLINIATQQF-----------DTESHVLQLNQY--IPEK---LI--------DELVAKV------------------------------------------------------------------------------------------EA-----PV-LT-------N---IIE---QDYFGK------N-ELSL--SGVMIGLA-------M-SS------------------------------SVSNE---EAMS-KG-TEVAKQL--IEAINK-NDKYNKS-------PITFAIFK-------------------QES--TSSLKNGT-------YI----A--------SATVQKN-DTN--L-GN--------WST-----IDEKSYSYPSDE---------FTQA-HGEDNTK----INN--FAKEIK----GF-NGDFIPVNAKVSYKKDQMDTLN-------MNI-------V----IKY---N-----GKTELMA-----LTQLAA-----Q-------------------------------------------------GMLDKLPKDA---KVQLQIKSESK-IE-----AVII--K--EKNSD------------------------------------------------------------
23 HHSearch 52.9029% -4 - C4 -3N2Q - ? A:[56-340] ------------------------------------------------------------------------------------------------------------------------------AP---LKEQKVI--NTA-NI-K------T----------------NS---------KLDLAEYENGLINIATQQF-----------DTESHVLQLNQY--IPEK---LI--------DELVAKV-----------------E-------------------------------------------------------------------------A-----P-VLT-------N---IIE---QDYFGK------N-ELSL--SGVMIGLA-------M-SS------------------------------SVSNE---EAMS-KG-TEVAKQL--IEAINK-NDKYNKS-------PITFAIFK-------------------QES--TSSLKNGT-------YI----A--------SATV--QKNDT--NLGN--------WST-----IDEKSYSYPSDE---------FTQA-HGEDNTK----INN--FAKEIK----GF-NGDFIPVNAKVSYKKDQMDTLN-------MNI-------V----IKY---N-----GKTELMA-----LTQLAA-----Q-------------------------------------------------GMLDKLPKDA---KVQLQIKSESK-IE-----AVII--K--EKNSDKPFVSFL-----------------------------------------------------
41 Fugue 47.8318% -16 - C5 -4PG7 ? A:[20-446] ----------------------------------HMKKLNIALLGLGTVG------------SGVVK---------IIEENRQQIQDT-----LNKDIV-IKHILVRDK-SKK--RPLNI------SQ---YHLTEDV--NEI-LN-DDSLDIIV----------------EV---------MGGIEPTVDWLRTALKNK---------------KHVITANKD--LLAV---HL--------KLLEDLA-----------------E-----------------EN----------------GVA-L--------KF-EASVAGG-----P--N-----NI-----SKFMGILNGTSNF---ILS---KMTKEQ---TTFE-EALD--EAKRLGFAEADPTDDV-EG----------VDAARKVVITSYLS---FNQVIKLN---DVKR-RGISGVTLTD--INVADQ-L-GYKIK-------LIGKGIYE-------------------NGK--VNASVEPT-------LIDKKHQ--------LAAV--E-DEY--N-AI--------YVI-----GDAVGDTMFYGK---------GAGS-LATGSAV----VSD--LLNVAL----FFES-TLPP-----HFELKTDKTRE-------MEK-------S----NFF---V-----VVNHVKG-----SIENFE-----N-------------------------------------------------ELKAILPFHR---SLRVANYDNQS-YA-----AVIVGLE--SSPEELITKHGYEVDKVYPVEGV------------------------------------------
37 Fugue 43.7717% 21 - C3 -4BVA CRYM_MOUSE A:[24-334] ----------------------------------KRAPAFLSAEEVQDHL------------RSSSL---------LIPPLEAALANF-----SKG--P-DGGVMQPV---------RTV------VP---V--AKHR--GFLGVM-P------A----------------YS---------A-------------AEDAL-----------TTKLVTFYES-----HQA---SV--------LLF---------------------------------------DP----------------SNG-S--------LL-AVMDGNV-----I--T-----AK-----RTAAV-------S---AIA---TKLLKP---PGSD-VLCI--LGAGVQAY-------S-HY----------EIFTEQ--FSFKEVRM-WNRTRENA---EKFA-ST-VQGDVRV--CSSVQE-AVTGADV-------IITVTMAT-------------------EPILFGEWVKPG--------------A--------HINA--V-GAS--R-PD--------WRE-----LD-----------------------------DE----LMR--QAVLYV----DS--------REAALKESGDVLLSG-------ADI-------F----AE----------------------LGEVIS-----G-------------------------------------------------AKPAHCEKT------TVFKSLGMA-VE-----DLVA--A--KLVYDSWSSG-------------------------------------------------------
38 Fugue 42.8518% 4 - C1 -4X7P ? A:[1-493] ----------MKKIFMMVHELDVNKGGMTSSMFNRSKEFYDADIPADIVT------------FDYKG---------NYDEIIKALKKQGKMDRRTK--M-YNVFEYFKQISNNKHFKSNK------LL---YKHISER--LKN-TI-E------IEESKGISRYFDITTGTYI---------AYIRKSKSEKVIDFFKDNK-----------RIERFSFIDNKV--HMKE---TFNVDNKVCYQVFYDEKGYPYIS-----------R-----------------NI----------------NAN-N--------GA-VGKTYVL-----V--N-----KK-----EFKNN-------L---ALC---VYYLEKLIKDSKD-SIMICDGPGSFPKM-------F-NTNHKNAQKYGVIHVNHH--ENFDDT---GAFKKSEK---YIIE-NA-NKINGVI--VLTEAQ-RLDILNQ-------FDVENIFTISNFVKIHNAPKHFQTEKIVGH--ISRMVPTK-------RI----D--------LLIE--V-AEL--V-VK--------KDNAVKFHIYGEGSVKDKIA---------KMIE-DKNLERN----VFLKGYTTTPQ----KCLE-DFKLVVSTSQYEGQGLSMIE-------AMI-------SKRPVVAFDIKY-----GPSDFIE-----DNKNGY-----L-------------------------------------------------IENHNINDMA---DKILQLVNNDV-LA-----AEFG--S--KARENIIEKYSTESILEKWLNLFNS----------------------------------------
39 Fugue 42.7215% -12 - C5 -2D7I GLT10_HUMAN A:[35-570] GQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYV------------SDKISLNRSLPDIRHPNCNSKRYLET-----LPN--T-SIIIPFHNEGWSS--LLRTV------HS---VLNRSPP--ELV-AE-I------V----------------LVDDFSDREHLKKPLEDYMALFPSVRILRT-----------KKREGLIRTRML--GASVATGDV--------ITFLDSH-----------------C-----------------EA----------------NVN-W--------LP-PLLDRIA-----R--N-----RK-----TIVCP-------M---IDVIDHDDFRYE---TQAG-DAMR--GAFDWEMY-------Y-KR----------IPIPPE--LQKADPSDPFESPVMAG---GLFA-VD-RKWFWELGGYDPGLE-IWGGEQY-------EISFKVWM-------------------CGG--RMEDIPCS-------RV----GHIYRKYVPYKVP--A-GVS--L-ARNLKRVAEVWMD-----EYAEYIYQRRPEYRHLSAGDVAVQK-KLRSSLN----CKS--FKWFMT----KIAW-DLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSP----LRL---EGCVRGRGEAAWN-----NMQVFTFTWRED-------------------------------------------------IRPGDPQHTK---KFCFDAISHTS-PV-----TLYD--C--HSMKGNQLWKYRKDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFNRN
42 Fugue 42.2020% 0 - C2 -4R1D ? A:[45-561] -------------------------------QTAPLPVIFIPGIMGTNLRNKADKSEVWRPPNGLWP---------MDDLFASIGALWTWAWRGPK--A-RQELLKAEQVEVD--DQGTIDVGQSGLS---EEAARLRGWGKV-MR-S------A----------------YN---------PV-MGLMERRLDNIVSRRELQAWWNDEALSPPGDQGEEQGKVGPIDEE---EL--------LRASRYQ-----------------F-----------------DV----------------WCA-G--------YNWLQSNRQS-----A--L-----DV-----RDYIE-------N---TVL---PFYQKE---CGLD-PEQM--RRMKVILV-------T-HS----------MGGLVA--RALTQL---HGYERVLG---VVHGVQP-ATGSSTI--YHHMRCGYEGIAQVVLGRNAGEVTAIVAN-------------------SAG--ALELAPSAEYREGRPWL----F--------LCDA--Q-GQV--L------------KD-----IDGKPRAYPQNQ---------DPYE-EIYKNTT----WYG--LVPEQN----SQYL-DMSDKKEGLRVGPRDNFEDL-------IDS-------I----ANF---H-----GELSAAGYHSETYAHYGA-----DDSRHSWRDLIWKGDPTPLETPGATLNDDENGTYNSWFRRGLPTIVQGPLETGNPLDASGSGGDETVPTDSGQA-PALAGVKASFR--HGSKGKGQANTKRGYEHQESYNDARAQWAALYGVIKITQLADW-------------------------
40 Fugue 40.3215% 4 * C5 *1NVM - ACDH_PSEUF B:[1-312] ----------------------------------MNQKLKVAIIG------------------------------------------------SGN--I-GTDLMIKVLRNAK--YLEMG------AM---V--GIDA--ASD-GL-A------R----------------AQ---------RMGVTTTYAGVEGLIKLPE-----------FADIDFVFDATS--ASAH---VQ--------NEALLRQ-----------------A-----------------KP----------------GIR-L--------ID-LTPAAIG---------------------PYCVP-------V---VNL---EEHLGK---LNVN-MVTC--GGQATIPM-------V-AA----------VSRVAK--VHYAEI---VASISSKSAGPGTRA-NI-DEFTETT--SKAIEV-IGGAAKG-------KAIIIMNP-------------------AEP--PLIMRDTV-------YV----L--------S-------------------------AA-----ADQAAVAASVAE---------MVQA-VQAYVPG----YRL--KQQVQF----DVIP-ESAPLNIPGL---GRFSGLK-------TSV-------F----LEV---E-----GA-------------------------------------------------------------------------AHYLPAYA-------------G-NL-----DIMT--S--AALATAERMAQSMLNA-------------------------------------------------
43 Fugue 35.5410% 17 - C5 -4FFL ? A:[1-363] -----------------------------------MKTICLVGGKLQGFE------------AAYLS---------KKAGMKVVLVDK-----NPQ--ALIRNYADEFYCFDV--IKEPE------KL---LELSKRV--DAV-LP-V------N----------------EN---------LACIEFLNS-IKEKFSCPV-----------LFDFEAYRISR----DKK---KS--------KDYFKSI-----------------G-----------------VP----------------TPQ-DRPSKPPYFVK-PPCESSS-----V--G-----AR-----IIYGL-------EPDTLVE---EYVEGE---VVSL-EVVG--DGSHFAVV-------K-ET----------LVHIDE--TYDCHM---VTPLPANP---LFRQ-IS-HDLAANL-------P-LKGIMDV-------EAIFG-------------------------------PKGL-------RV----I--------EIDA--R---------------------------------FPSQT---------PTVV-YYSSGIN----LIE--LLFRAFTDGVEEIE-NKYCIYEHLMFGENGVLIPV-------GEQ-------V----LSM---G-----SDYGKFY-----EEPGIE-----I-------------------------------------------------FLCKGEYPVF---TMVFWGKDREE-TG-----AKRC--K--GLSVLKERFGAVL----------------------------------------------------
7 PsiBlast_PDB 34.7431% -10 - C4 -4PG5 - ? A:[21-120] -----------------------------------MKKLNIALLGLGTVG------------SGVVK---------IIEENRQQIQDT-----LNK---------------DI--VIKHI------LV---RDKSKKR--PLN-IS-Q------Y----------------HL---------TEDVNEI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 34.6031% -11 - C4 -4PG4 ? A:[21-121] -----------------------------------MKKLNIALLGLGTVG------------SGVVK---------IIEENRQQIQDT-----LNK---------------DI--VIKHI------LV---RDKSKKR--PLN-IS-Q------Y----------------HL---------TEDVNEI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8 PsiBlast_PDB 33.5831% -20 - C4 -4PG7 ? A:[21-112] -----------------------------------MKKLNIALLGLGTVG------------SGVVK---------IIEENRQQIQDT-----LNK---------------DI--VIKHI------LV---RDKSKKR--PLN-IS-Q------Y----------------HL---------TEDVNEI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10 PsiBlast_PDB 33.2831% -16 - C4 -4PG6 ? A:[21-122] -----------------------------------MKKLNIALLGLGTVG------------SGVVK---------IIEENRQQIQDT-----LNK---------------DI--VIKHI------LV---RDKSKKR--PLN-IS-Q------Y----------------HL---------TEDVNEI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9 PsiBlast_PDB 32.6331% -8 - C4 -4PG8 ? A:[21-115] -----------------------------------MKKLNIALLGLGTVG------------SGVVK---------IIEENRQQIQDT-----LNK---------------DI--VIKHI------LV---RDKSKKR--PLN-IS-Q------Y----------------HL---------TEDVNEI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------