@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1786: (2016-03-28 )
LKKNNWLQNAVIAMLVLIVGLCINMGSGTKVQAESIQRPTPINQVFPDPGLANAVKQNLGKQSVTDLVSQKELSGVQNFNGDNSNIQSLAGMQFFTNLKELHLSHNQISDLSPLKDLTKLEELSVNRNRLKNLNGIPSACLSRLFLDNNELRDTDSLIHLKNLEILSIRNNKLKSIVMLGFLSKLEVLDLHGNEITNTGGLTRLKKVNWIDLTGQKCVNEPVKYQPELYITNTVKDPDGRWISPYYISNGGSYVDGCVLWELPVYTDEVSYKFSEYINVGETEAIFDGTVTQPIKN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......----------------------130....----------------------.-.-----------------------.140.......150--------------------.........160.......170----------------------.----------------------......180.......190......---.200..-------------------.....210.......220.......230.......240.......250.......260.......270.......280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LKKN
N
W
L
Q
N
A
V
I
A
M
L
V
L
I
V
G
L
C
INMGSG
T
K
V
Q
A
E
SIQRPTPINQVFPDP
G
L
A
N
A
V
K
Q
N
LG
K
Q
S
V
T
D
L
V
S
Q
K
E
LSGVQNFNGDN
S
N
I
Q
S
L
A
G
M
Q
F
F
T
N
L
K
E
L
HLSHNQISDLS
P
L
K
D
L
T
K
L
E
E
LSV
N
R
N
R
----------------------LKNLNGI----------------------
P
-
S
-----------------------
A
C
L
S
R
L
FLDNNE----------------------LRDTD
S
L
I
H
L
KN
L
E
I
L
S
IRNN
K
----------------------
L
----------------------
K
S
I
V
M
L
G
F
L
S
K
L
E
V
L
DLHGNEITNT---GGL
T
R
L
-------------------
K
K
V
N
W
I
DLT
G
Q
K
CVNEPVKYQP
E
L
Y
I
T
NTVKDPDG
R
W
I
S
P
Y
Y
ISNGGSYV
D
G
C
V
L
WELPVYT
D
E
V
S
Y
K
F
S
E
YINVGET
E
A
I
FDGTVTQPIKN
62
HHSearch
94.33
100%
-110
- C2 -
1XEU
-
?
A:
[37-297]
-----------------------------------
I
Q
R
P
T
P
I
N
Q
V
F
P
D
P
G
L
A
N
A
V
K
Q
N
L
G
K
Q
S
V
T
D
L
V
S
Q
K
E
L
S
G
V
Q
N
F
N
G
D
N
S
N
I
Q
S
L
A
G
M
Q
F
F
T
N
L
K
E
L
H
L
S
H
N
Q
I
S
D
L
S
P
L
K
D
L
T
K
L
E
E
L
S
V
N
R
N
R
----------------------
L
K
N
L
N
G
I
----------------------
P
-
S
-----------------------
A
C
L
S
R
L
F
L
D
N
N
E
----------------------
L
R
D
T
D
S
L
I
H
L
K
N
L
E
I
L
S
I
R
N
N
K
----------------------
L
----------------------
K
S
I
V
M
L
G
F
L
S
K
L
E
V
L
D
L
H
G
N
E
I
T
N
T
---
G
G
L
T
R
L
-------------------
K
K
V
N
W
I
D
L
T
G
Q
K
C
V
N
E
P
V
K
Y
Q
P
E
L
Y
I
T
N
T
V
K
D
P
D
G
R
W
I
S
P
Y
Y
I
S
N
G
G
S
Y
V
D
G
C
V
L
W
E
L
P
V
Y
T
D
E
V
S
Y
K
F
S
E
Y
I
N
V
G
E
T
E
A
I
F
D
G
T
V
T
Q
P
I
K
N
1
PsiBlast_PDB
94.12
100%
-108
- C2 -
1XEU
-
?
A:
[35-297]
---------------------------------
E
S
I
Q
R
P
T
P
I
N
Q
V
F
P
D
P
G
L
A
N
A
V
K
Q
N
L
G
K
Q
S
V
T
D
L
V
S
Q
K
E
L
S
G
V
Q
N
F
N
G
D
N
S
N
I
Q
S
L
A
G
M
Q
F
F
T
N
L
K
E
L
H
L
S
H
N
Q
I
S
D
L
S
P
L
K
D
L
T
K
L
E
E
L
S
V
N
R
N
R
----------------------
L
K
N
L
N
G
I
----------------------
P
-
S
-----------------------
A
C
L
S
R
L
F
L
D
N
N
E
----------------------
L
R
D
T
D
S
L
I
H
L
K
N
L
E
I
L
S
I
R
N
N
K
----------------------
L
----------------------
K
S
I
V
M
L
G
F
L
S
K
L
E
V
L
D
L
H
G
N
E
I
T
N
T
---
G
G
L
T
R
L
-------------------
K
K
V
N
W
I
D
L
T
G
Q
K
C
V
N
E
P
V
K
Y
Q
P
E
L
Y
I
T
N
T
V
K
D
P
D
G
R
W
I
S
P
Y
Y
I
S
N
G
G
S
Y
V
D
G
C
V
L
W
E
L
P
V
Y
T
D
E
V
S
Y
K
F
S
E
Y
I
N
V
G
E
T
E
A
I
F
D
G
T
V
T
Q
P
I
K
N
24
PsiBlast_CBE
75.46
35%
-100
- C2 -
2WQU
6
INLB_LISMO
F:
[5-288]
----------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
64
HHSearch
75.09
39%
-97
- C2 -
1H6T
-
INLB_LISMO
A:
[38-321]
-----------------------------------
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
----------------------
V
K
D
L
S
S
L
----------------------
K
-
D
L----------------------
K
K
L
K
S
L
S
L
E
H
N
G
----------------------
I
S
D
I
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
TDITVLSRLTKLDTLSLEDNQI
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
E
6
PsiBlast_PDB
75.07
35%
-97
- C2 -
2WQU
7
INLB_LISMO
A:
[4-288]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLK
S
L
S
LEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
23
PsiBlast_CBE
75.01
35%
-98
- C2 -
2WQV
5
INLB_LISMO
B:
[5-288]
----------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
25
PsiBlast_CBE
74.60
35%
-98
- C2 -
2WQU
5
INLB_LISMO
E:
[5-288]
----------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
83
Fugue
74.54
38%
-92
- C2 -
1H6T
-
INLB_LISMO
A:
[31-321]
----------------------------
G
P
L
G
S
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
----------------------
V
K
D
L
S
S
L
----------------------
K
-
D
LKKLKSLSLEHNGISDINGLVHL
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
E
21
PsiBlast_CBE
74.26
35%
-100
- C2 -
4AW4
6
INLB_LISMO
C:
[4-310]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
L
T
S
L
N
L
S
N
N
Q
I
T
D
I
S
P
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
----------------------
L
T
D
I
K
P
L
----------------------
A
-
N
L----------------------
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
----------------------
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
VPL
A
G
L
T
K
L
QNLYLSKNHISDLRALAGL
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
3
PsiBlast_PDB
74.14
35%
-97
- C2 -
1H6T
-
INLB_LISMO
A:
[35-320]
--------------------------------
S
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
10
PsiBlast_PDB
73.82
35%
-98
- C2 -
2WQW
5
INLB_LISMO
A:
[1-285]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLK
S
L
S
LEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
C
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
C
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
A
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
28
PsiBlast_CBE
73.51
35%
-99
- C2 -
2WQW
7
INLB_LISMO
B:
[1-285]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
C
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
C
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
A
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
2
PsiBlast_PDB
73.37
35%
-101
- C2 -
4AW4
14
INLB_LISMO
A:
[4-310]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
L
T
S
L
N
L
S
N
N
Q
I
T
D
I
S
P
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
----------------------
L
T
D
I
K
P
L
----------------------
A
-
N
L----------------------
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLK
S
L
S
L
E
HNG
I
S
D
I
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
----------------------
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
VPL
A
G
L
T
K
L
Q
N
L
Y
L
S
KNHISDLRALAGL
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
------
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
22
PsiBlast_CBE
72.81
35%
-99
- C2 -
4AW4
9
INLB_LISMO
B:
[4-310]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
L
T
S
L
N
L
S
N
N
Q
I
T
D
I
S
P
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
----------------------
L
T
D
I
K
P
L
----------------------
A
-
N
L----------------------
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
V
H
L
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
----------------------
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
I
S
D
I
VPL
A
G
L
T
K
L
QNLYLSKNHISDLRALAGL
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
8
PsiBlast_PDB
72.77
35%
-98
- C2 -
2Y5Q
3
INLB_LISMO
A:
[5-290]
--------------------------------
S
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
4
PsiBlast_PDB
72.68
35%
-97
- C2 -
2UZX
-
INLB_LISMO
A:
[36-320]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLK
S
L
S
L
E
HNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
7
PsiBlast_PDB
72.29
35%
-97
- C2 -
2WQV
4
INLB_LISMO
A:
[5-288]
----------------------------------
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLK
S
L
S
LEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
----
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
27
PsiBlast_CBE
72.24
35%
-93
- C2 -
2WQU
6
INLB_LISMO
B:
[4-288]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLKSLSLEHNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
S
D
I
V
P
L
A
G
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
A
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
C
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
-----
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
9
PsiBlast_PDB
72.18
35%
-94
- C2 -
2WQX
-
INLB_LISMO
A:
[36-320]
---------------------------------
E
T
I
T
V
P
T
P
I
K
Q
I
F
S
D
D
A
F
A
E
T
I
K
D
N
L
K
K
K
S
V
T
D
A
V
T
Q
N
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
G
I
Q
Y
L
P
N
V
T
K
L
F
L
N
G
N
K
L
T
D
I
K
P
L
A
N
L
K
N
L
G
W
L
F
L
D
E
N
K
VKDLSSLKDLKKLK
S
L
S
L
E
HNG
I
S
D
I
N
G
L
----------------------
V
-
H
L----------------------
P
Q
L
E
S
L
Y
L
G
N
N
K
----------------------
I
T
D
I
T
V
L
S
R
L
T
K
L
D
T
L
S
L
E
D
N
Q
----------------------
I
----------------------
R
R
I
V
P
L
A
R
L
T
K
L
Q
N
L
Y
L
S
K
N
H
I
S
D
L
---
R
A
L
R
G
L
-------------------
K
N
L
D
V
L
E
L
F
S
Q
E
A
L
N
K
P
I
N
H
Q
S
N
L
V
V
P
N
T
V
K
N
T
D
G
S
L
V
T
P
E
I
I
S
D
D
G
D
Y
E
K
P
N
V
K
W
H
L
P
E
F
T
N
E
V
S
F
I
F
Y
Q
P
V
T
I
G
K
A
K
A
R
F
H
G
R
V
T
Q
P
L
K
-
63
HHSearch
71.50
38%
-94
- C2 -
1H6U
-
?
A:
[39-343]
------------------------------------
T
Q
P
T
A
I
N
V
I
F
P
D
P
A
L
A
N
A
I
K
I
A
A
G
K
S
N
V
T
D
T
V
T
Q
A
D
L
D
G
I
T
T
L
S
A
F
G
T
G
V
T
T
I
E
G
V
Q
Y
L
N
N
L
I
G
L
E
L
K
D
N
Q
I
T
D
L
A
P
L
K
N
L
T
K
I
T
E
L
E
L
S
G
N
P
----------------------
L
K
N
V
S
A
I
AGLQSIK
T
L
D
LTSTQITDVTPL
A
G
L
-----------------------
S
N
L
Q
V
L
Y
L
D
L
N
Q
----------------------
I
T
N
I
S
P
L
A
G
L
T
N
L
Q
Y
L
S
I
G
N
A
Q
VSDLTPLANLSKLT
T
L
K
A
D
DNK
I
----------------------
S
D
I
S
P
L
A
S
L
P
N
L
I
E
V
H
L
K
N
N
Q
I
S
D
V
---
S
P
L
A
N
T
-------------------
S
N
L
F
I
V
T
L
T
N
Q
T
I
T
N
Q
P
V
F
Y
N
N
N
L
V
V
P
N
V
V
K
G
P
S
G
A
P
I
A
P
A
T
I
S
D
N
G
T
Y
A
S
P
N
L
T
W
N
L
T
S
F
I
N
N
V
S
Y
T
F
N
Q
S
V
T
F
K
N
T
T
V
P
F
S
G
T
V
T
Q
P
L
T
E