@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1795: (2016-03-28 )
MKPVIGITGNRLVKGVDVFYGHRVTYTQQRYVDAIQKVGGFPIALPIDDPSVAVQAISLVDGLLLTGGQDITPQFYLEEPSQEIGAYFPPRDSYEIALVRAALDAGKPIFAICRGMQLVNVALGGSLYQDISQVETKALQHLQRVDEQLGSHTIDIEPTSELAKHHPNKKLVNSLHHQFIKKLAPSFKVTARTADGMIEAVEGDNLPSWYLGVQWHPELMFQTDPESEQLFQALVDESKKTMVK
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30......----.----.40-.........-50--------------....-.-..--.60........-70.........80........90....-....100-.....--..110.......120.....-------..130..---.--.----.-..--------.---140.------.-.---------..-..150.....-------...160..-------...--------.--------.170...-----------------.--.------..180------.--------..-.-.....190...-.-...200--....-....-210.......220------------...-------------.....230.......240..---------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK
P
V
I
GITGN
R
L
V
K
G
V
D
V
F
YGHRVT
Y
T
Q
Q
R
Y
V
D
A
I
Q
K----V----GG--
F
P
I
A
L
PIDD-
P
S
--------------
V
A
V
Q
-
A
-
I
S
--
L
V
D
G
L
LLTGGQ-D-IT
P
Q
F
Y
LEEP
S
Q
E
IGAYFPPRDS
Y
E
-
I
A
L
V
R
A
A
-
L
DAGK--
P
I
F
A
I
CRG
M
Q
L
V
N
V
ALG
G
S
L
-------
Y
Q
D
-
I
S
Q
---
V
--
E
----
T
-
K
A
--------
L
---
Q
H
L
Q
------
R
-
V
---------
D
E
-
Q
LG-S
H
T
I
DI-------E
P
T
S
E
L
A
K
-------HHP--------
N
--------
K
K
L
V
N
S
L
-----------------
H
--
H
------
Q
F
I
--------
K
--------
K
L-A-PS
F
K
V
T
A
RTAD-
G
-
M
I
E
AV---EGDN-L
P
S
W
-
Y
L
G
V
Q
W
H
P
E
L
M
F-------------QTD-------------P
E
S
E
Q
L
F
Q
A
L
V
D
E
S
K
K
TMVK---------------------------------
24
HHSearch
98.96
98%
-85
- C4 -
3FIJ
1
?
A:
[3-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
V
I
G
I
T
G
------------------
Q
Q
R
Y
V
D
A
I
Q
K
----
V
----
G
G
--
F
P
I
A
L
P
I
D
D
-
P
S
--------------
T
A
V
Q
-
A
-
I
S
--
L
V
D
G
L
L
L
T
G
G
Q
-
D
-
I
T
P
Q
L
Y
L
E
E
P
S
Q
E
I
G
A
Y
F
P
P
R
D
S
Y
E
-
I
A
L
V
R
A
A
-
L
D
A
G
K
--
P
I
F
A
I
C
R
G
M
Q
L
V
N
V
A
L
G
G
T
L
-------
Y
Q
D
-
I
S
Q
---
V
--
E
----
T
-
K
A
--------
L
---
Q
H
L
Q
------
R
-
V
---------
D
E
-
Q
L
G
-
S
H
T
I
D
I
-------
E
P
T
S
E
L
A
K
-------
H
H
P
--------
N
--------
K
K
L
V
N
S
L
-----------------
H
--
H
------
Q
F
I
--------
K
--------
K
L
-
A
-
P
S
F
K
V
T
A
R
T
A
D
-
G
-
M
I
E
A
V
---
E
G
D
N
-
L
P
S
W
-
Y
L
G
V
Q
W
H
P
E
L
M
F
-------------
Q
T
D
-------------
P
E
S
E
Q
L
F
Q
A
L
V
D
E
S
K
K
T
M
-----------------------------------
22
PsiBlast_CBE
98.72
96%
-87
- C4 -
3FIJ
1
?
D:
[3-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
V
I
G
I
T
G
------------------
Q
Q
R
Y
V
D
A
I
Q
K
----
V
----
G
G
--
F
P
I
A
L
P
I
D
D
-
P
S
--------------
T
A
V
Q
-
A
-
I
S
--
L
V
D
G
L
L
L
T
G
G
Q
-
D
-
I
T
P
Q
L
Y
L
E
E
P
S
Q
E
I
G
A
Y
F
P
P
R
D
S
Y
E
-
I
A
L
V
R
A
A
-
L
D
A
G
K
--
P
I
F
A
I
C
R
G
M
Q
L
V
N
V
A
L
G
G
T
L
-------
Y
Q
D
-
I
S
Q
---
V
--
E
----
T
-
K
A
--------
L
---
Q
H
L
Q
------
R
-
V
---------
D
E
-
Q
L
G
-
S
H
T
I
D
I
-------
E
P
T
S
E
L
A
K
-------
H
H
P
--------
N
--------
K
K
L
V
N
S
L
-----------------
H
--
H
------
Q
F
I
--------
K
--------
K
L
-
A
-
P
S
F
K
V
T
A
R
T
A
D
-
G
-
M
I
E
A
V
---
E
G
D
N
-
L
P
S
W
-
Y
L
G
V
Q
W
H
P
E
L
M
F
-------------
Q
T
D
-------------
P
E
S
E
Q
L
F
Q
A
L
V
D
E
S
K
K
T
------------------------------------
1
PsiBlast_PDB
98.53
96%
-85
- C4 -
3FIJ
1
?
A:
[3-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
V
I
G
I
T
G
------------------
Q
Q
R
Y
V
D
A
I
Q
K
----
V
----
G
G
--
F
P
I
A
L
P
I
D
D
-
P
S
--------------
T
A
V
Q
-
A
-
I
S
--
L
V
D
G
L
L
L
T
G
G
Q
-
D
-
I
T
P
Q
L
Y
L
E
E
P
S
Q
E
I
G
A
Y
F
P
P
R
D
S
Y
E
-
I
A
L
V
R
A
A
-
L
D
A
G
K
--
P
I
F
A
I
C
R
G
M
Q
L
V
N
V
A
L
G
G
T
L
-------
Y
Q
D
-
I
S
Q
---
V
--
E
----
T
-
K
A
--------
L
---
Q
H
L
Q
------
R
-
V
---------
D
E
-
Q
L
G
-
S
H
T
I
D
I
-------
E
P
T
S
E
L
A
K
-------
H
H
P
--------
N
--------
K
K
L
V
N
S
L
-----------------
H
--
H
------
Q
F
I
--------
K
--------
K
L
-
A
-
P
S
F
K
V
T
A
R
T
A
D
-
G
-
M
I
E
A
V
---
E
G
D
N
-
L
P
S
W
-
Y
L
G
V
Q
W
H
P
E
L
M
F
-------------
Q
T
D
-------------
P
E
S
E
Q
L
F
Q
A
L
V
D
E
S
K
K
T
M
-----------------------------------
21
PsiBlast_CBE
97.41
96%
-84
- C4 -
3FIJ
1
?
F:
[3-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
V
I
G
I
T
G
------------------
Q
Q
R
Y
V
D
A
I
Q
K
----
V
----
G
G
--
F
P
I
A
L
P
I
D
D
-
P
S
--------------
T
A
V
Q
-
A
-
I
S
--
L
V
D
G
L
L
L
T
G
G
Q
-
D
-
I
T
P
Q
L
Y
L
E
E
P
S
Q
E
I
G
A
Y
F
P
P
R
D
S
Y
E
-
I
A
L
V
R
A
A
-
L
D
A
G
K
--
P
I
F
A
I
C
R
G
M
Q
L
V
N
V
A
L
G
G
T
L
-------
Y
Q
D
-
I
S
Q
---
V
--
E
----
T
-
K
A
--------
L
---
Q
H
L
Q
------
R
-
V
---------
D
E
-
Q
L
G
-
S
H
T
I
D
I
-------
E
P
T
S
E
L
A
K
-------
H
H
P
--------
N
--------
K
K
L
V
N
S
L
-----------------
H
--
H
------
Q
F
I
--------
K
--------
K
L
-
A
-
P
S
F
K
V
T
A
R
T
A
D
-
G
-
M
I
E
A
V
---
E
G
D
N
-
L
P
S
W
-
Y
L
G
V
Q
W
H
P
E
L
M
F
-------------
Q
T
D
-------------
P
E
S
E
Q
L
F
Q
A
L
V
D
E
S
K
K
T
------------------------------------
56
Fugue
62.55
18%
-63
- C4 -
1S1M
14
PYRG_ECOLI
A:
[1-544]
MT
T
N
Y
I
F
V
T
G
G
VVSSLG
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
GLN
V
T
I
M
K
L
D
PYINVDPGTMSPIQH
G
E
V
F
V
T
EDG
A
E
T
D
L
D
L
G
H
Y
E
R
F
IR
T
K
M
S
RRNNFT
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
GDYLGATVQVIP
H
I
T
N
A
I
K
E
R
V
L
E
G
G
EGHD
V
V
L
V
E
I
G
G
TVGDIES
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
GREH
T
L
F
M
H
L
T
L
V
P
Y
M
AASGEVKT
K
P
T
Q
H
S
V
K
E
L
L
S
I
GIQPD
I
L
I
C
R
S
DRAVP
A
N
E
R
A
K
I
A
LFCNVPEKAV
I
S
L
K
DVDSIYK
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
ANL
S
E
W
E
Q
V
I
F
E
E
A
N
PV
S
E
V
T
I
G
M
V
G
-
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
----
N
----
I
K
--
L
I
D
S
Q
D
V
E
T
-
R
G
--------------
V
--
E
-
I
-
L
K
--
G
L
D
A
I
L
V
P
G
G
F
-
G
-
Y
R
G
------------------
V
E
G
M
-
I
T
T
A
R
F
A
-
R
E
N
N
I
--
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
ANMENAN
S
T
E
-
F
V
P
---
D
--
C
----
K
-
Y
P
--------
V
---
V
A
L
I
------
T
-
E
WRDENGNVE
T
M
-
R
L
G
-
A
Q
Q
C
Q
L
-------
V
D
D
S
L
V
R
Q
-------
L
Y
N
--------
A
--------
P
T
I
V
E
R
H
-----------------
R
--
H
R
Y
EVNN
M
L
L
--------
K
--------
Q
I
-
E
D
A
G
L
R
V
A
G
R
S
G
D
D
Q
-
L
V
E
I
I
---
E
V
P
N
-
H
P
-
W
-
F
V
A
C
Q
F
H
P
E
F
T
S
-------------
T
P
R
--------------
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A-------------------------------
5
PsiBlast_PDB
62.02
24%
-80
- C4 -
1L9X
1
GGH_HUMAN
A:
[30-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
I
I
G
I
L
M
Q
K
C
R
N
K
V
M
K
N
Y
G
R
Y
--
Y
I
A
A
S
Y
V
K
Y
L
E
S
----
A
----
G
A
R
V
V
P
V
R
L
D
L
T
E
-
K
D
--------------
Y
E
I
L
-
F
-
K
S
---
I
N
G
I
L
F
P
G
G
S
V
D
-
L
R
R
S
D
Y
-----
A
K
V
A
K
I
F
-----
Y
N
-
L
S
I
--
Q
S
-
F
D
D
G
D
Y
F
P
V
W
G
T
C
L
G
F
E
E
L
S
L
L
I
S
G
E
C
-------
L
L
T
-
A
T
D
---
T
--
V
----
D
-
V
A
--------
M
---
P
-
L
N
------
F
-
T
---------
G
G
-
Q
L
H
-
S
R
M
F
Q
N
-------
F
P
T
-
E
L
L
L
-------
S
L
A
--------
V
--------
E
P
L
T
A
N
F
-----------------
H
--
K
------
W
S
L
S
V
K
N
F
T
M
N
E
--------
K
L
-
K
-
K
F
F
N
V
L
T
T
N
T
D
-
G
-
K
I
E
F
I
S
T
M
E
G
Y
K
-
Y
P
V
Y
---
G
V
Q
W
H
P
E
-------------------------------------------------------------------------------------
45
HHSearch
58.87
22%
-76
- C4 -
3TQI
-
GUAA_COXBU
A:
[20-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
I
A
R
R
V
R
E
----
I
----
G
V
--
Y
C
E
L
M
P
C
D
I
-
D
----------------
E
E
T
-
I
R
D
F
--
N
P
H
G
I
I
L
S
G
G
P
-
E
-----------------------------
A
P
A
F
I
-
F
E
I
G
C
--
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
-------
N
----------------------------------------------------------
E
F
G
-
H
A
Q
L
R
V
-------
L
N
P
A
F
L
F
D
-------
G
I
E
--------
D
QVSPQG
E
P
L
L
D
V
W
M
S
-----------------
H
--
G
------
D
I
V
--------
S
--------
E
L
-
P
-
P
G
F
E
A
T
A
C
T
D
N
-
S
-
P
L
A
A
M
---
A
D
F
---
K
R
R
-
F
F
G
L
Q
F
H
P
E
V
T
H
-------------
T
---------------
P
Q
G
H
R
I
L
A
H
F
V
I
H
----------------------------------------
26
HHSearch
58.68
19%
-55
- C4 -
2A9V
3
GUAAA_THEAC
A:
[25-204]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
H
R
E
W
R
V
L
R
E
----
L
----
G
V
--
D
T
K
I
V
P
N
D
I
-
D
-----------------
S
S
-
E
-
L
D
--
G
L
D
G
L
V
L
S
G
G
A
-
P
N
I
D
E
E
------
L
D
K
-----------
L
-
G
S
V
G
K
Y
I
-
D
D
H
N
Y
--
P
I
L
G
I
C
V
G
A
Q
F
I
A
L
H
F
G
A
S
V
-------
V
K
A
-
K
H
P
----------------------------------------------------
E
F
G
-
K
T
K
V
S
V
-------
M
H
S
E
N
I
F
G
-------
G
L
P
--------
S
--------
E
I
T
V
W
E
N
-----------------
H
--
N
------
D
E
I
--------
I
--------
N
L
-
P
-
D
D
F
T
L
A
A
S
S
A
T
-
C
-
Q
V
Q
G
F
---
Y
H
K
---
T
R
P
-
I
Y
A
T
Q
F
H
P
E
V
E
H
-------------
T
---------------
Q
Y
G
R
D
I
F
R
N
F
I
G
I
C
A
S
Y
R
E
----------------------------------
31
HHSearch
58.38
18%
-66
- C4 -
2V4U
-
PYRG2_HUMAN
A:
[298-552]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
S
I
A
L
V
G
K
Y
T
K
L
R
----------
D
C
Y
A
S
V
F
K
A
L
E
H
----
S
A
L
A
I
N
H
--
K
L
N
L
M
Y
I
D
S
-
I
D
LE
K
I
T
E
T
E
D
P
V
K
F
H
E
A
W
Q
-
K
-
L
C
--
K
A
D
G
I
L
V
P
G
G
F
-
G
-
I
R
G
T
------------------
L
G
K
-
L
Q
A
I
S
W
A
-
R
T
K
K
I
--
P
F
L
G
V
-
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
-------
L
N
L
-
K
D
A
---
D
--
S
TEFR
P
-
N
A
PVPL
V
I
D
M
P
---
E
H
N
P
GNL---
G
-
G
---------
T
M
-
R
L
G
I
R
R
T
V
F
K
-------
T
E
N
S
I
L
R
K
-------
L
Y
G
--------
D
--------
V
P
F
I
E
E
R
-----------------
H
R
H
R
------
F
E
V
--------
N
PNLIK---
Q
F
E
Q
-
N
D
L
S
F
V
G
Q
D
V
D
-
G
D
R
M
E
I
I
---
E
L
A
---
N
H
P
Y
F
V
G
V
Q
F
H
P
E
F
S
S
-------------
R
P
--------------
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
L
N
----------------------------------
33
HHSearch
58.21
21%
-64
- C4 -
2YWB
-
GUAA_THET8
A:
[12-215]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
L
I
A
R
R
L
R
E
----
L
----
R
A
--
F
S
L
I
L
P
G
D
A
-
P
----------------
L
E
E
-
V
L
K
H
--
R
P
Q
A
L
I
L
S
G
G
P
-
R
-
S
-
V
--
F
D
P
-
D
A
---------------
P
R
P
D
P
R
L
-
F
S
S
G
L
--
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
-------
E
R
A
--------------------------------------------------------
E
Y
G
-
K
A
L
L
T
R
-------
H
-
E
G
P
L
F
R
-------
G
L
E
--------
G
--------
E
V
Q
V
W
M
S
-----------------
H
--
Q
------
D
A
V
--------
T
--------
A
P
-
P
-
P
G
W
R
V
V
A
E
T
E
E
-
N
-
P
V
A
A
I
---
A
S
P
---
D
G
R
-
A
Y
G
V
Q
F
H
P
E
V
A
H
-------------
T
---------------
P
K
G
M
Q
I
L
E
N
F
L
E
L
A
G
V
-------------------------------------
25
HHSearch
58.21
20%
-37
* C4 *
1L9X
1
GGH_HUMAN
A:
[30-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
I
I
G
I
L
M
Q
K
C
R
N
K
V
M
K
--
N
Y
G
R
Y
Y
I
A
A
S
Y
V
K
Y
L
E
S
----
A
----
G
A
--
R
V
V
P
V
R
L
D
L
-
T
E
K
-------------
D
Y
E
I
-
L
-
F
K
--
S
I
N
G
I
L
F
P
G
G
S
V
D
-
L
R
R
S
D
Y
A
K
V
A
-----------
K
I
F
Y
-
N
L
S
I
Q
S
F
D
D
G
D
Y
F
--
P
V
W
G
T
C
L
G
F
E
E
L
S
L
L
I
S
G
E
C
-------
L
L
T
-
A
T
D
---
T
--
V
----
D
-
V
-------------
A
M
--------
P
-
L
---------
N
F
T
G
G
Q
-
L
H
S
R
M
F
QN-----
F
P
T
E
L
L
L
S
-------
L
A
---------
V
--------
E
P
L
T
A
N
F
-----------------
H
--
K
------
W
S
L
--------
S
V
K
N
F
T
M
N
E
K
L
-
K
-
K
F
F
N
V
L
T
T
N
T
D
-
G
-
K
I
E
F
I
---
S
T
M
E
G
Y
K
Y
P
-
V
Y
G
V
Q
W
H
P
E
K
A
P
-------------
Y
E
W
KNLDGISHA
P
N
A
V
K
T
A
F
Y
L
A
E
F
F
V
N
E
A
R
K
N
N
H
H
---------------------------------
17
PsiBlast_PDB
57.98
21%
-68
- C4 -
2NV0
-
PDXT_BACSU
A:
[14-192]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
H
I
H
A
I
E
A
----
C
----
G
A
----
A
G
L
V
V
K
R
-
P
------------------
E
-
Q
-
L
N
--
E
V
D
G
L
I
L
P
G
G
E
-
S
-
T
T
M
R
R
L
I
--------------
D
T
Y
Q
F
M
E
P
L
R
E
F
-
A
A
Q
G
K
--
P
M
F
G
T
C
A
G
L
I
I
L
A
K
E
I
A
-----------
P
H
-
L
G
L
---
L
---------
N
V
--------
V
---
V
E
R
N
------
S
-
F
---------
G
R
-
Q
V
D
-
S
F
E
A
D
L
T
I
K
GLD-
E
P
F
T
G
V
F
I
-------
R
A
P
--------
H
--------------------------------------------
I
--------
L
--------
E
A
-
G
-
E
N
V
E
V
L
S
E
H
N
G
-
R
-
I
V
A
A
K
---
Q
G
Q
-------
F
L
G
C
S
F
H
P
E
L
T
---------------
E
D
-------------
H
R
V
T
Q
L
F
V
E
M
V
E
E
Y
K
Q
-------------------------------------
44
HHSearch
57.09
22%
-82
- C4 -
2VXO
-
GUAA_HUMAN
A:
[42-222]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
V
I
D
R
R
V
R
E
----
L
----
F
V
--
Q
S
E
I
F
P
L
E
T
-
P
----------------
A
F
A
I
K
-
E
Q
--
G
F
R
A
I
I
I
S
G
G
P
-------------
A
P
W
---------------
F
D
P
A
I
-
F
T
I
G
K
--
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
-------
H
K
-------------------------------------------------------------
V
F
N
I
S
V
-------
D
N
T
C
S
L
F
R
-------
G
L
Q
--------
K
--------
E
E
V
V
L
L
T
-----------------
H
--
G
------
D
S
V
--------
D
--------
K
V
-
A
-
D
G
F
K
V
V
A
R
S
G
N
---
I
V
A
G
I
---
A
N
E
---
S
K
K
-
L
Y
G
A
Q
F
H
P
E
V
G
L
-------------
T
---------------
E
N
G
K
V
I
L
K
N
F
L
Y
-----------------------------------------
34
HHSearch
55.82
19%
-62
- C4 -
3UOW
-
?
A:
[20-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
L
I
V
K
R
L
N
N
----
I
----
K
I
--
F
S
E
T
K
D
Y
G
V
-
E
----------------
L
K
D
-
I
K
D
M
--
N
I
K
G
V
I
L
S
G
G
P
-
Y
-
S
-
V
--
T
E
-
A
G
S
P
H
----------
L
K
-
K
E
V
F
E
Y
F
-
L
E
K
K
I
--
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
-------
K
K
S
-
K
T
S
---
E
--
Y
----
G
-
C
T
--------
D
---
V
N
I
L
------
R
N
D
NINNITYCR
N
F
-----
S
S
A
M
D
L
Y
S
N
Y
K
L
M
N
--
C
C
L
F
E
-------
N
I
K
S-------
D
--------
I
T
T
V
W
M
N
-----------------
H
--
N
------
D
E
V
--------
T
--------
K
I
-
P
-
E
N
F
Y
L
V
S
S
S
E
N
-
C
-
L
I
C
S
I
---
Y
N
K
---
E
Y
N
-
I
Y
G
V
Q
Y
H
P
E
V
Y
E
-------------
S
---------------
L
D
G
E
L
M
F
Y
N
F
A
Y
N
----------------------------------------
30
HHSearch
55.54
21%
-79
- C4 -
2VPI
-
GUAA_HUMAN
A:
[39-214]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
D
R
R
V
R
E
----
L
----
F
V
--
Q
S
E
I
F
P
L
E
T
-
P
----------------
A
F
A
I
K
-
E
Q
--
G
F
R
A
I
I
I
S
G
---------------
A
P
W
---------------
F
D
P
A
I
-
F
T
I
G
K
--
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
-------
H
K
K
-
S
V
R
----------------------------------------------------
E
D
G
-
V
F
N
I
S
V
-------
D
N
T
C
S
L
F
R
-------
G
L
Q
--------
K
--------
E
E
V
V
L
L
T
-----------------
H
--
G
------
D
S
V
--------
D
--------
K
V
-
A
-
D
G
F
K
V
V
A
R
S
-
G
-
N
-
I
V
A
G
I
---
A
N
E
---
S
K
K
-
L
Y
G
A
Q
F
H
P
E
V
G
L
-------------
T
---------------
E
N
G
K
V
I
L
K
N
F
L
Y
D
I
A
G
C
S
-----------------------------------
39
HHSearch
55.21
21%
-59
- C4 -
1GPM
1
GUAA_ECOLI
A:
[20-224]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
L
V
A
R
R
V
R
E
----
L
----
G
V
--
Y
C
E
L
W
A
W
D
V
-
T
----------------
E
A
Q
-
I
R
D
F
--
N
P
S
G
I
I
L
S
G
G
P
-
E
-
S
T
---
T
E
E
-
N
S
---------------
P
R
A
P
Q
Y
V
-
F
E
A
G
V
--
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
-------
E
A
S
-
N
E
---------------------------------------------------
R
-
E
F
G
-
Y
A
Q
V
E
V
-------
V
N
D
S
A
L
V
R
-------
G
I
E
DALTADG
K
P
--------
L
L
D
V
W
M
S
-----------------
H
--
G
------
D
K
V
--------
T
--------
A
I
-
P
-
S
D
F
I
T
V
A
S
T
E
S
-
C
-
P
F
A
I
M
---
A
N
E
---
E
K
R
-
F
Y
G
V
Q
F
H
P
E
V
T
H
-------------
T
---------------
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
--------------------------------------
38
HHSearch
54.89
16%
-62
- C4 -
3NVA
-
PYRG_SULSO
A:
[309-534]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
----
G
V
--
R
P
K
L
I
W
I
E
S
-
T
D
LESDTK--------
N
L
N
E
-
I
-
L
G
--
N
V
N
G
I
I
V
L
P
G
F
-
G
-
S
-
R
G
--
A
---------------
E
G
K
-
I
K
A
I
K
Y
A
-
R
E
H
N
I
--
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
-------
L
G
L
-
S
E
A
NST
E
--
I
----
N
P
N
T
KDP-----
V
I
T
L
L
D
E
Q
KNVTQL
G
-
G
---------
T
M
-
R
L
G
-
A
Q
K
I
I
L
-------
K
E
G
T
I
A
Y
Q
-------
L
Y
G
K-------
K
--------
V
V
Y
E
R
H
R
-----------------
H
--
R
------
Y
E
V
--------
N
PKY
V
D
---
I
L
E
D
-
A
G
L
V
V
S
G
I
S
E
N
-
G
-
L
V
E
I
I
---
E
L
P
S
--
N
K
F
-
F
V
A
T
Q
A
H
P
E
F
K
S
-------------
R
P
--------------
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
-------------------------------------
3
PsiBlast_PDB
53.94
26%
-80
- C4 -
2VXO
-
GUAA_HUMAN
A:
[59-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
E
T
-
P
A
--------------
F
A
I
K
-
E
-
Q
G
--
F
-
R
A
I
I
I
S
G
G
P
-----------------
A
P
W
F
D
P
-----------
A
I
-
F
T
I
G
K
--
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
------------------------------------------
H
K
--------------------------
V
F
N
I
S
V
-------
D
N
T
C
S
L
F
R
-------
G
L
Q
--------
K
--------
E
E
V
V
L
L
T
-----------------
H
--
G
------
D
S
V
--------
D
--------
K
V
-
A
-
D
G
F
K
V
V
A
R
S
---
G
-
N
I
V
A
G
---
I
A
N
E
-
S
K
K
L
-
Y
-
G
A
Q
F
H
P
E
V
------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.76
18%
-52
- C4 -
3UOW
-
?
A:
[13-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
----
L
----
N
N
--
I
K
I
F
S
E
T
K
D
-
Y
G
--------------
V
E
L
K
-
D
-
I
K
DM
N
I
K
G
V
I
L
S
G
G
P
-
Y
-
S
V
T
E
A
G
S
P
H
L
K
K
E
V
F
E
Y
F
----------------
L
E
K
K
I
--
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
-------
K
K
S
K
T
S
E
---
Y
--
G
----
C
-
T
D
--------
V
---
N
I
L
R
------
N
-
D
---------
N
I
-
N
N
I
-
T
Y
C
R
N
F
----------
S
S
A
M
D
-------
L
Y
S
--------
N
--------
Y
K
L
M
N
--CCLFENIKSD
I
T
T
V
W
M
N
H
--
N
------
D
E
V
--------
T
--------
K
I
-
P
-
E
N
F
Y
L
V
S
S
S
E
N
-
C
-
L
I
C
S
I
---
Y
N
K
E
-
Y
N
I
Y
---
G
V
Q
Y
H
P
E
V
Y
E
-------------
S
L
D
-------------
G
E
---------------------------------------------------
54
Fugue
53.14
19%
-46
- C4 -
1L9X
1
GGH_HUMAN
A:
[28-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
K
K
P
I
I
G
I
L
M
Q
K
C
R
N
K
V
M
K
N
Y
G
R
--
Y
Y
I
A
A
S
Y
V
K
Y
L
E
S
----
A
----
G
A
--
R
V
V
P
V
R
L
D
L
T
E
K
--------------
D
Y
E
I
-
L
-
F
K
--
S
I
N
G
I
L
F
P
G
G
S
-
V
-
D
L
R
R
S
D
Y
A
K
V
A
K
I
F
Y
N
L
S
I
Q
S
F
D
D
G
-
D
Y
F
------------
P
V
W
G
T
C
L
G
F
E
E
L
S
L
L
I
S
G
E
C
-------
L
L
T
-
A
T
D
---
T
VD
V
----
A
-
M
P
--------
L
---
N
F
T
G
------
G
-
Q
---------
L
H
-
S
R
M
-
F
Q
N
F
P
T
-------
E
L
L
L
S
L
A
V
EPL
T
A
N
F
H
K
W
--------
S
--------
L
S
V
K
N
F
T
-----------------
M
--
N
------
E
K
L
--------
K
--------
K
F
-
F
-
N
V
L
T
T
N
T
D
G
K
I
-
E
-
F
I
S
T
M
---
E
G
Y
K
-
Y
P
---
V
Y
G
V
Q
W
H
P
E
K
A
P
YEWKNLDGISHA
P
N
A
V
-------------
K
T
A
F
Y
L
A
E
F
F
V
N
E
A
R
K
N
N
H
H
FKS
E
S
E
E
E
K
A
LIYQ
F
S
P
I
YTGNISSFQ
Q
C
Y
I
F
D