@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1820: (2016-03-29 )
MMIGKRLSDRYKILHAIGGGGMANVYLAHDIILDRDVAVKILRIDLADESNLIRRFQREAQSATSLVHPNIVSVYDVGEENDLHYIVMEHVDGMDLKQYIHENHPISYEKAVDIMLQIVSAVAIAHQHHIIHRDLKPQNILIDHDGVVKITDFGIAMALSETSITQTNSLLGSVHYLSPEQARGGMATQKSDIYSLGIVLYELLTGKVPFDGESAVSIAIKHLQADIPSAREQNPEIPQSLENIIIKATAKDPFLRYQNAEEMEKDLQTCLNKDRLNEPKYVFPTDDGDTKAIPIIATKDTMQNLDKTIVPEGKVAAAEVVPEEKKDKKKKKMSKKKKIALIVSSVIIIFIIGILLLWLLGKSPDEVAVPDVSGKTEDQAVALLQKEGFVIGKTAEKNSDEVDEGKVINTDPEAGEMKEKGTKINLFVSIGSKKITMDDYTGRSYTDTKALLEEQGFKNISSEEAYSSEIEKGLIISQTPTQGTEVVAKSTDVKFVVSKGAEPITLKDLRGYTKTAVEDYASPLGLKVSSKEENSSTVEKGQVISQSPSAGTAMNSGDTIEIVISAGPKEKQVKEVTKTFNIPYTPSDEENPQPQKIQIYIQDKDHSMTSAYREMSITQNTSVEITFQIEEGSSAGYKIISDDKVIDEGTVPYPN
Atome Classification :
(25 SA)
.........10........20........30........40........50.---.......60........70........--80---.........90........100.......110.......120.......130.......140.---......150.......160.......170.......180..-...-..190.......200.......210.......220...--.--...-230...-.-...240.......250.......260.......270.......280.......290.......300.........310.--......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
I
G
K
R
L
S
D
R
Y
K
I
L
H
AIGGG
G
M
A
N
V
Y
L
A
H
D
I
ILDRD
V
A
V
K
I
L
R
I
DLAD
E
S
N
L
---
I
R
R
F
Q
R
E
A
Q
S
A
TSLVHP
N
I
V
S
V
Y
DVGE--E----N
D
L
H
Y
I
V
M
E
HVDG
M
D
L
K
Q
Y
I
HENHPI
S
Y
E
K
A
V
D
I
M
L
Q
I
V
S
A
V
A
I
A
H
Q
H
H
I
I
HRDLKPQ
N
I
L
ID---HD
G
V
V
K
I
TDF
G
I
A
M
A
LSETSI
T
Q
T
N
S
L
L
GSVHYL
S
P
E
Q
ARG-GMA-TQKS
D
I
Y
S
L
G
I
V
L
Y
E
L
LTGKVPFDG
E
S
A
V
S
I
A
I
K
H
L
QA--D--IPS-AREQNP-E-
I
P
Q
S
L
E
N
I
I
I
K
ATAKDP
F
L
RYQ
N
A
E
E
M
E
K
D
L
Q
T
C
L
N
KDRLNEP
K
Y
V
F
PTDDGDT
K
A
I
P
I
I
A
T
K
D
--
T
M
Q
N
L
D
K
TIVPEG--
K
V
A
A
A
EVVP
E
E
K
K
D
K
K
K
K
K
M
S
K
K
K
K
I
A
L
I
V
S
S
V
I
I
I
F
I
I
G
I
L
L
L
W
L
LGKSPDEVAVPDVSGKT
E
D
Q
A
V
A
L
L
Q
KE
G
F
V
I
GKTAEKNSDEVDEG
K
V
INTDPEAG
E
M
KEKG
T
K
I
N
L
F
V
S
IG
S
K
K
I
T
MDDYTGRSYT
D
T
K
A
L
L
E
E
QGFKNIS
S
E
E
A
Y
S
S
E
I
EK
G
L
I
I
SQTPTQG
T
E
V
V
AKST
D
V
K
F
V
VSKGAE
P
I
T
L
K
D
LRG
Y
T
K
T
A
V
E
D
YASPL
G
L
K
VSSKEENSSTVEKG
Q
V
ISQSPSAGTAMNSG
D
T
I
E
I
V
ISAGP
K
E
K
Q
V
K
E
V
T
K
TFNIPYTPSDEENPQP
Q
K
I
Q
I
Y
I
QDKDH
S
M
T
S
A
Y
R
E
M
SITQNT
S
V
E
I
T
F
Q
IEEGSSAG
Y
K
I
ISDDKVIDEGTVPYPN
24
PsiBlast_CBE
84.27
50%
-92
- C2 -
4EQM
2
?
C:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
---
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
----
D
D
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
---
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
--
S
--
V
P
N
V
T
T
D
V
R
K
-
D
-
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.89
50%
-92
- C2 -
4EQM
2
?
A:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
---
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
----
D
D
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
---
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
--
S
--
V
P
N
V
T
T
D
V
R
K
-
D
-
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.83
50%
-93
- C2 -
4EQM
2
?
B:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
---
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
----
D
D
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
---
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
--
S
--
V
P
N
V
T
T
D
V
R
K
-
D
-
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.18
50%
-92
- C2 -
4EQM
1
?
D:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
---
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
----
D
D
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
---
S
N
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
--
S
--
V
P
N
V
T
T
D
V
R
K
-
D
-
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.82
50%
-91
- C2 -
4EQM
1
?
F:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
---
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
----
D
D
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
---
S
N
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
--
S
--
V
P
N
V
T
T
D
V
R
K
-
D
-
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.81
50%
-92
- C2 -
4EQM
1
?
E:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
---
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
----
D
D
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
---
S
N
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
--
S
--
V
P
N
V
T
T
D
V
R
K
-
D
-
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.72
46%
-87
- C2 -
3ORK
3
?
A:
[4-289]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
----------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.67
45%
-86
- C2 -
3F61
5
PKNB_MYCTU
A:
[4-289]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
-----------------
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
D
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.02
46%
-83
- C2 -
3ORP
1
?
A:
[4-289]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
--------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.69
47%
-85
- C2 -
2FUM
1
PKNB_MYCTU
A:
[23-293]
--
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
ETPA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
D
----------
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.63
46%
-80
- C2 -
3ORO
2
?
A:
[12-289]
--------
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
ETPA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
------
T
A
A
V
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.30
46%
-84
- C2 -
3ORT
2
?
A:
[4-289]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
R
----------------
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.99
47%
-90
- C2 -
1O6Y
3
PKNB_MYCTU
A:
[23-293]
--
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
--------------
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.67
46%
-85
- C2 -
3ORM
2
?
A:
[13-289]
---------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
A
T
G
E
--
A
ETPA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
PI
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
76.49
47%
-91
- C2 -
2FUM
1
PKNB_MYCTU
C:
[23-293]
--
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
---
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
ETPA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
---
A
T
N
A
V
K
V
M
D
F
--------------------
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
--
D
P
I
P
P
S
-
A
R
H
E
G
----
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.25
40%
-87
- C2 -
4OW8
2
PKNA_MYCTU
A:
[5-264]
--
V
G
V
T
L
S
G
R
Y
R
L
Q
R
L
I
A
T
G
G
M
G
Q
V
W
E
A
V
D
N
R
L
G
R
R
V
A
V
K
V
L
K
S
E
F
S
S
D
P
E
F
---
I
E
R
F
R
A
E
A
R
T
T
A
M
L
N
H
P
G
I
A
S
V
H
D
Y
G
E
S
Q------
R
T
A
Y
L
V
M
E
L
V
N
G
E
P
L
N
S
V
L
K
R
T
G
R
L
S
L
R
H
A
L
D
M
L
E
Q
T
G
R
A
L
Q
I
A
H
A
A
G
L
V
H
R
D
V
K
P
G
N
I
L
I
T
---
P
T
G
Q
V
K
I
T
D
F
G
I
A
K
A
V
D
A
A
P
V
T
Q
T
G
M
V
M
G
T
A
Q
Y
I
A
P
E
Q
A
L
G
-
H
D
A
-
S
P
A
S
D
V
Y
S
L
G
V
V
G
Y
E
A
V
S
G
K
R
P
F
A
G
D
G
A
L
T
V
A
M
K
H
I
K
E
--
P
--
P
P
P
-
L
P
P
D
L
P
-
P
-
N
V
R
E
L
I
E
I
T
L
---
V
K
N
P
A
M
R
Y
R
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Fugue
68.50
27%
-56
- C2 -
3H4J
-
SNF1_SCHPO
B:
[27-356]
---
S
K
R
H
I
G
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
S
D
M
---
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
T
--
T
----
P
T
D
I
V
M
V
I
E
Y
A
-
G
G
E
L
F
D
Y
I
V
E
K
K
R
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
---
D
N
L
N
V
K
I
A
D
F
G
L
S
N
I
M
T
D
G
N
F
L
K
T
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
-
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
F
D
D
E
F
-----
I
P
N
L
F
K
--
K
--
V
N
S
-
C
V
Y
V
M
P
-
D
F
L
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
-
I
T
I
Q
E
I
R
R
D
P
W
F
N
V
N
L
P
D
Y
L
R
P
M
E
E
V
Q
G
S
Y
A
D
S
R
I
V
S
K
L
G
E
A
M
GF
S
E
D
Y
I
V
E
A
L
R
S
D
E
NN
E
V
K
E
A
Y
N
L
L
H
E
N
Q
V
I
Q
E
K
L
E
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
65.90
31%
-77
- C2 -
3FE3
-
MARK3_HUMAN
A:
[52-303]
------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
-
P
T
S
---
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
--
T
----
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
G
G
--
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
-
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
--
K
--
Y
R
-----
I
P
F
-
Y
-
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
-
L
E
Q
I
M
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
HHSearch
64.49
31%
-84
- C2 -
3H4J
-
SNF1_SCHPO
B:
[27-281]
---
S
K
R
H
I
G
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
S
D
M
---
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
T
--
T
----
P
T
D
I
V
M
V
I
E
Y
A
-
G
G
E
L
F
D
Y
I
V
E
K
K
R
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
---
D
N
L
N
V
K
I
A
D
F
G
L
S
N
I
M
T
D
G
--
N
F
L
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
-
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
F
D
D
E
F
I
P
N
L
F
K
K
V
N
S
C
--
V
--
Y
-----
V
M
P
D
-
F
-
L
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
I
T
-
I
Q
E
I
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.92
34%
-87
- C2 -
3IEC
1
MARK2_HUMAN
A:
[9-245]
----------
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
---
Q
K
L
F
-
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
--
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
--
T
F
G
N
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
-----
L
K
E
L
R
E
--
R
--
V
L
R
-
G
K
Y
R
I
P
F
Y
-
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
57.46
32%
-89
- C2 -
4BKY
2
MELK_HUMAN
A:
[12-230]
----------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-----
D
K
N
T
L
D--
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
---
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
--
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
57.19
32%
-84
- C2 -
4BL1
1
MELK_HUMAN
A:
[12-230]
----------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-----
D
K
N
T
L
---
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
---
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
--
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
57.11
32%
-86
- C2 -
4CQG
2
MELK_MOUSE
A:
[11-220]
----------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
-----
D
K
N
A
L
GSD
L
P
R
V
K
T
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
---
E
N
H
K
L
K
L
I
D
F
G
L
C
A
K
------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
------
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
54.75
32%
-83
- C2 -
4BKZ
1
MELK_HUMAN
A:
[12-230]
----------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-----
D
K
N
T
L
---
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
---
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
--
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
52.62
32%
-88
- C2 -
3HZT
9
?
A:
[3-241]
-------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
T
T
S
N
---
S
G
A
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
SKS
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
E
V
G
----------
T
A
Y
Y
I
A
P
E
V
L
R
K
-
K
Y
--
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------