@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1838: (2016-03-29 )
MKNLLSMEALTVHEIEHLLEQAAQFKRGKKATFNEQTFAVNMFFEPSTRTHTSFEVAEKKLGVEVVSFDAASSSMTKGETLYDTLLTMQAVGVNVAVIRHSEENYYAGLEKLDIAIVNGGDGCGEHPSQSLLDLFTIKEQFGTFQGLKVAIAGDIRHSRVANSNMKVLKRLGAELFFSGPREWFDESYLAYGTYLPVDEIVEKVDVMMLLRVQHERHSGTDEFTKESYHEKFGLTEDRAKKLKEDAIIMHPSPVNRDVEIADSLVESEKSRIVTQMTNGVFIRMAILEAILKEQEMRAKLCTY
Atome Classification :
(49 SA)
.........10........20........30---..----.......40........50........60.......-.70.....-....80........90...--.....100..--.-....-110------.......120.......130.......140.......150.......160.......170........180--------...--.....---------190.......200.......210.......220.--......230.......240.......250.......260.......270.......280.......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKN
L
L
S
M
E
A
L
T
V
H
E
I
E
H
L
L
E
Q
A
A
Q
F
KRGKK----AT----FNE
Q
T
F
A
V
N
M
F
FEPSTRTHT
S
F
E
V
A
E
KKL
G
V
E
V
V
S
F-DA-ASSSM-TKG
E
T
L
Y
D
T
L
L
T
M
Q
AVG
V
N
--
V
A
V
I
RHSEE
N
--
Y
-YAG
L
-
E
K
L
------
D
I
A
I
VNGGDGCGEH
P
S
Q
S
L
L
D
L
F
T
I
K
E
Q
FGTFQ
G
L
K
V
A
I
AGDI
R
H
S
RVANS
N
M
K
V
L
K
R
L-
G
A
E
LFFS
G
P
R
---------
E
W
F
--DE
S
Y
L
---------AYGTYL
P
V
D
E
I
V
E
K
V
D
V
M
M
L
L
R
V
Q
H
ERHSG
T
D
E
F
--
T
K
E
S
Y
H
E
KFGL
T
E
D
R
A
K
K
LKE
D
A
I
I
MHPSPVN
R
D
V
E
I
A
D
S
L
V
E
S
E
K
S
R
I
V
T
Q
MTNG
V
F
I
R
M
A
I
L
E
A
I
L
K
E
Q
E
M
R
A
KLCTY
27
PsiBlast_CBE
97.88
57%
-103
- C5 -
3R7F
8
PYRB_BACSU
B:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
29
PsiBlast_CBE
96.43
57%
-103
- C5 -
3R7D
2
PYRB_BACSU
B:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
3
PsiBlast_PDB
96.29
57%
-101
- C5 -
3R7F
7
PYRB_BACSU
A:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
26
PsiBlast_CBE
96.26
57%
-101
- C5 -
3R7F
7
PYRB_BACSU
C:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
28
PsiBlast_CBE
95.99
57%
-102
- C5 -
3R7D
4
PYRB_BACSU
C:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
21
PsiBlast_CBE
94.65
57%
-96
- C5 -
3R7L
3
PYRB_BACSU
F:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----------
110
HHSearch
94.59
58%
-96
- C5 -
3R7F
7
PYRB_BACSU
A:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
-
V
S
Q
V-----
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
T
----------
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
22
PsiBlast_CBE
94.13
57%
-96
- C5 -
3R7L
3
PYRB_BACSU
E:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----------
24
PsiBlast_CBE
93.83
57%
-95
- C5 -
3R7L
3
PYRB_BACSU
C:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----------
2
PsiBlast_PDB
93.73
57%
-99
- C5 -
3R7D
3
PYRB_BACSU
A:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
25
PsiBlast_CBE
93.64
57%
-95
- C5 -
3R7L
3
PYRB_BACSU
B:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----------
4
PsiBlast_PDB
93.47
57%
-96
- C5 -
3R7L
3
PYRB_BACSU
A:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----------
23
PsiBlast_CBE
93.22
57%
-97
- C5 -
3R7L
3
PYRB_BACSU
D:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
----
D
N
----
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
--
Y
-
Y
E
E
L
V
S
Q
V
------
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
---------
E
W
Q
--
D
E
E
N
----------
T
F
G
T
Y
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----------
12
PsiBlast_PDB
78.93
31%
-80
- C5 -
1EKX
2
PYRB_ECOLI
A:
[8-306]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
18
PsiBlast_PDB
78.52
31%
-85
- C5 -
1RAF
-
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
6
PsiBlast_PDB
78.39
40%
-86
- C5 -
4BJH
14
PYRB_AQUAE
B:
[32-316]
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
E
----
E
T
----
I
K
A
S
--
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
E
S
S
T
-
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
--
Y
V
V
F
R
V
P
F
V
F
FP
Y
-
K
E
I
V
-
K
S
L
------
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
---------
T
L
I
PR
D
V
E
V
F
---------
K
V
D
V
F
D
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
--
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
-----------------
16
PsiBlast_PDB
78.27
31%
-83
- C5 -
1RAD
-
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
54
PsiBlast_CBE
78.12
31%
-81
- C5 -
2FZK
1
PYRB_ECOLI
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
44
PsiBlast_CBE
78.12
31%
-76
- C5 -
4KGV
1
?
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
20
PsiBlast_PDB
78.12
31%
-84
- C5 -
1RAH
-
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
53
PsiBlast_CBE
78.02
31%
-76
- C5 -
2H3E
1
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
33
PsiBlast_CBE
77.90
31%
-79
- C5 -
1EKX
3
PYRB_ECOLI
C:
[8-306]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
34
PsiBlast_CBE
77.62
31%
-80
- C5 -
1EKX
3
PYRB_ECOLI
B:
[8-306]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
43
PsiBlast_CBE
77.43
31%
-76
- C5 -
4KGV
1
?
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
51
PsiBlast_CBE
77.41
31%
-78
- C5 -
2IPO
2
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
36
PsiBlast_CBE
77.38
31%
-75
- C5 -
4KH1
2
?
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
58
PsiBlast_CBE
77.32
31%
-82
- C5 -
2FZC
1
PYRB_ECOLI
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
37
PsiBlast_CBE
77.25
31%
-79
- C5 -
4KH0
1
?
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
35
PsiBlast_CBE
77.22
31%
-77
- C5 -
4KH1
1
?
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
42
PsiBlast_CBE
77.18
31%
-76
- C5 -
4KGX
1
?
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
46
PsiBlast_CBE
77.09
31%
-78
- C5 -
4F04
1
PYRB_ECOLI
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
5
PsiBlast_PDB
76.96
40%
-79
- C5 -
3D6N
1
PYRB_AQUAE
B:
[1-285]
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
E
----
E
T
----
I
K
A
S
--
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
E
S
S
T
-
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
--
Y
-
K
E
I
V
-
K
S
L
------
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
---------
T
L
I
PR
D
V
E
V
F
---------
K
V
D
V
F
D
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
--
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
-----------------
38
PsiBlast_CBE
76.81
31%
-76
- C5 -
4KH0
1
?
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
63
PsiBlast_CBE
76.64
31%
-83
- C5 -
1ZA2
3
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
56
PsiBlast_CBE
76.51
31%
-84
- C5 -
2FZG
1
PYRB_ECOLI
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
47
PsiBlast_CBE
76.39
31%
-78
- C5 -
4F04
1
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
65
PsiBlast_CBE
76.28
31%
-80
- C5 -
1R0C
2
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
41
PsiBlast_CBE
76.20
31%
-75
- C5 -
4KGX
1
?
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
57
PsiBlast_CBE
76.14
31%
-78
- C5 -
2FZG
1
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
8
PsiBlast_PDB
75.82
32%
-87
- C5 -
1ML4
1
PYRB_PYRAB
A:
[6-305]
-
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
E
L
K
----
E
K
GQLE
Y
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
A
-
S
T
S
S
V
-
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
--
V
I
V
I
R
H
P
K
E
G
--
A
A
R
L
A
A
-
E
V
A
------
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
LLRMP
R
H
I
V
E
E
L
--
R
E
K
G
M
---------
K
V
V
E
T
T
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
E
Y
L
K
V
K
G
S
Y
Q
V
N
L
K
V
L
E
----
K
A
K
D
E
L
R
I
M
H
P
L
P
--
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
------------
64
PsiBlast_CBE
75.79
31%
-80
- C5 -
1R0C
2
PYRB_ECOLI
G:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
52
PsiBlast_CBE
75.63
31%
-75
- C5 -
2H3E
1
PYRB_ECOLI
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
61
PsiBlast_CBE
75.61
31%
-82
- C5 -
2AIR
2
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
50
PsiBlast_CBE
75.47
31%
-78
- C5 -
2IPO
4
PYRB_ECOLI
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
60
PsiBlast_CBE
75.26
31%
-78
- C5 -
2AIR
2
PYRB_ECOLI
G:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
62
PsiBlast_CBE
74.93
31%
-80
- C5 -
1ZA2
2
PYRB_ECOLI
C:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
ATEFSG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMPQYIL
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
59
PsiBlast_CBE
74.50
31%
-77
- C5 -
2FZC
1
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------
116
HHSearch
73.63
31%
-84
* C5 *
1ML4
1
PYRB_PYRAB
A:
[5-307]
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
E
L
K
E
KGQ
L
E
----
Y
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
-
A
E
A
S
T
S
S
V
-
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
--
V
I
V
I
R
H
P
K
E
G
--
A
-
A
R
L
A
-
A
E
V
A-----
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
---------
L
L
R
--
M
P
R
H
I
V
E
E
L
R
E
K
GM
K
V
V
E
T
T
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
----
E
Y
L
K
V
K
G
S
Y
Q
V
N
L
K
V
L
E
K
A
K
D
E
L
R
I
M
H
P
L
P
R
V
--
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V
----------
55
PsiBlast_CBE
73.29
31%
-79
- C5 -
2FZK
1
PYRB_ECOLI
A:
[7-305]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
----
P
E
----
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
-
S
V
I
S
T
Y
V
D
--
A
I
V
M
R
H
P
Q
E
-------
G
A
-
A
R
L
A
T
E
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
L
--
D
E
K
G
I
---------
A
W
S
L
H
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
---
L
D
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
-----------