@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1918: (2016-03-30 )
MDYDVIVIGGGPSGLMAAISAAEKNKRVLLIEKGPKLGRKLIMSGGGRCNVTNRRPAEEIIKHIPGNGRFLYSAFHAFDNEDIIRFFERLGVALKEEDHGRMFPVSNSARSVAEAMIQRMEKLGVKIYMQTAVKQVDYEDGHVKGVTLKDGQEISASAVIVAVGGKSVPRTGSTGDGYAWAKKAGHTITELYPTEVPITSSEPFIKQKVLQGTSLRDVSLSVLNAKGKPIITHQMDMIFTHFGVSGPAALRCSMFVLRELKKTGAGTVKMRLDLFPNVSAAELSKDVYKLLEENPKKALKNSLSSLLQEKMLLFLLEKADLEETAEYKQVSPKKIEQFIQLLKDFTFEVNGTLDFEKAFVTGGGVSVKEIKPKEMQSKLMEGLFFCGEILDINGYTGGYNITCALVTGHTAGAYAAEVSNA
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------.........10........20........30........-40........-50.------------.-.-.-----.------....60..-.-----.------.------...70........80........90......------.---------.------100--------------------.---------.-----------------..-----....110.......120.......-130.....--.-.140.........----150.--........160...---------....------------------170--------........180...-....190.......200...-....210.......220.......230.......240....----.--..250....-...260...----.-----...270-........280.......290.---.--.....300--.......310....-.-----..320.......330.......340.......350.......360.....-..370....-----.------..380.......390--...--..--...400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------MDY
D
V
I
V
IGGG
P
S
G
L
M
A
A
I
S
AAEKN
K
R
V
L
L
IEKGPKL
G
R
-
K
L
I
MSGGGRC-N-V------------T-N-R-----R------
P
A
E
E
I
I
K
H-I-----P------G------N
G
R
F
L
Y
S
A
F
H
AFD
N
E
D
I
I
R
F
F
E
R
L
G
V
A
LKEE------D---------H------G
R
---------------------
M
---------F-----------------PV-----S
N
S
A
R
S
V
A
E
A
M
I
Q
R
M
E
KLG
V
K
I
Y
M
-
Q
T
A
V
K
QVD--Y-ED--G
H
V
K
G
V
T
LK----D--G--QEISA
S
A
V
I
V
A
VGG---------KSVP------------------RT---------GSTGDG
Y
A
W
A
K
KAG-
H
T
I
T
E
LYPTEVPITSSE
P
F
I
-
K
Q
K
V
LQGTSL
R
D
V
S
L
S
V
LNAKGK
P
I
I
T
H
Q
M
D
M
I
F
T
HFGVS
G
----
P
--
A
A
L
R
C
S
M
F
V
-
L
R
E
L
K
K
TGA----
G
-----
T
V
K
M
R
--
L
D
LFPNV
S
A
A
E
L
S
K
D
V
Y
K
L
L
EE---N--
P
K
K
A
L
K
N
S
--
L
S
S
L
L
Q
E
K
M
L
L
F
L
L
-
E
-----KA
D
L
E
E
T
A
E
YKQV
S
P
K
K
I
E
Q
F
I
Q
L
L
K
DF
T
F
EVN
G
T
L
D
F
E
K
A
F
VTGGG
V
S
V
-KEI
K
P
K
E
M
Q
-----
S
------
K
L
M
E
G
L
F
F
C
G
E
I
L
-D--ING--YT--G
G
Y
N
I
T
C
A
L
VTGHTAG
A
Y
A
AEVSNA
1
PsiBlast_PDB
91.57
63%
-110
- C2 -
2I0Z
2
?
A:
[25-441]
----------------------------------------------------------------------------------------------------------------------------
M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
-
K
L
A
I
S
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
R
-----
L
------
P
L
D
E
I
V
K
H
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
------
D
---------
H
------
G
R
---------------------
M
---------
F
-----------------
P
V
-----
S
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
R
T
-
N
T
P
V
E
T
I
E
--
Y
-
E
N
--
G
Q
T
K
A
V
I
L
Q
----
T
--
G
--
E
V
L
E
T
N
H
V
V
I
A
V
G
G
---------
K
S
V
P
------------------
Q
T
---------
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
-
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
N
E
P
F
I
-
R
D
R
S
L
Q
G
L
A
L
R
D
I
N
L
S
V
L
N
----
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
C
S
Q
F
V
-
V
K
A
L
K
K
F
K
T
----
N
-----
T
I
Q
M
S
--
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
---
D
--
P
K
K
G
I
K
N
V
--
L
K
G
Y
V
P
E
R
Y
F
L
F
L
L
-
E
-----
K
N
E
I
D
G
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
-
K
E
I
N
P
K
E
M
S
-----
S
------
K
F
T
N
G
L
Y
F
C
G
E
V
L
-
D
--
I
H
G
--
Y
T
--
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
----
149
Fugue
91.24
62%
-108
- C2 -
2I0Z
2
?
A:
[25-444]
----------------------------------------------------------------------------------------------------------------------------
M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
-
K
L
A
I
S
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
R
-----
L
------
P
L
D
E
I
V
K
H
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
------
D
---------
H
------
G
R
---------------------
M
---------
F
-----------------
P
V
-----
S
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
R
T
-
N
T
P
V
E
T
I
E
--
Y
-
E
N
--
G
Q
T
K
A
V
I
L
Q
----
T
--
G
--
E
V
L
E
T
N
H
V
V
I
A
V
G
G
---------
K
S
V
P
------------------
Q
T
---------
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
-
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
N
E
P
F
I
-
R
D
R
S
L
Q
G
L
A
L
R
D
I
N
L
S
V
----
L
N
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
C
S
Q
F
V
-
V
K
A
L
K
K
F
K
T
----
N
-----
T
I
Q
M
S
--
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
---
D
--
P
K
K
G
I
K
N
V
--
L
K
G
Y
V
P
E
R
Y
F
L
F
L
L
-
E
-----
K
N
E
I
D
G
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
-
K
E
I
N
P
K
E
M
S
-----
S
------
K
F
T
N
G
L
Y
F
C
G
E
V
L
-
D
--
I
H
G
--
Y
T
--
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
-
127
HHSearch
89.54
63%
-105
- C2 -
2I0Z
2
?
A:
[26-444]
-----------------------------------------------------------------------------------------------------------------------------
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
-
K
L
A
I
S
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
R
-----
L
------
P
L
D
E
I
V
K
H
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
------
D
---------
H
------
G
R
---------------------
M
---------
F
-----------------
P
V
-----
S
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
R
T
-
N
T
P
V
E
T
I
E
--
Y
-
E
N
--
G
Q
T
K
A
V
I
L
Q
----
T
--
G
--
E
V
L
E
T
N
H
V
V
I
A
V
G
G
---------
K
S
V
P
------------------
Q
T
---------
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
-
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
N
E
P
F
I
-
R
D
R
S
L
Q
G
L
A
L
R
D
I
N
L
S
V
L
N
----
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
C
S
Q
F
V
-
V
K
A
L
K
K
F
------
K
-----
T
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
---
R
M
L
K
Q
M
K
E
D
--
P
K
K
G
I
K
N
V
--
L
K
G
Y
V
P
E
R
Y
F
L
F
L
L
-
E
-----
K
N
E
I
D
G
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
-
K
E
I
N
P
K
E
M
S
-----
S
------
K
F
T
N
G
L
Y
F
C
G
E
V
L
-
D
--
I
H
G
--
Y
T
--
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
-
21
PsiBlast_CBE
78.83
45%
-104
- C3 -
4CNK
13
?
B:
[4-387]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
-
K
L
A
G
T
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
N
-----
G
------
N
L
D
D
L
M
A
G
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
------
D
---------
H
------
G
R
---------------------
V
---------
F
-----------------
P
V
-----
T
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
-
N
T
E
I
V
S
V
K
--
K
-
T
D
---
E
L
F
T
V
R
S
S
----
D
-----
Q
A
W
T
C
Q
K
L
I
V
T
T
G
G
---------
K
S
Y
P
------------------
S
T
---------
G
S
T
G
F
G
H
D
I
A
R
H
F
K
-
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
D
F
P
----
H
K
A
L
Q
G
I
S
L
D
D
V
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
L
S
S
F
V
---------
K
----
G
-----
G
E
T
I
Y
--
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
---
H
--
R
E
K
S
L
K
N
C
--
L
K
I
L
L
P
E
R
I
A
D
F
F
T
-
Q
-----
P
F
----
P
E
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
T
L
E
-----
S
------
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
--
I
N
A
--
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
S
--------
3
PsiBlast_PDB
78.57
45%
-106
- C3 -
4CNK
11
?
A:
[4-387]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
-
K
L
A
G
T
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
N
-----
G
------
N
L
D
D
L
M
A
G
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
------
D
---------
H
------
G
R
---------------------
V
---------
F
-----------------
P
V
-----
T
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
-
N
T
E
I
V
S
V
K
--
K
-
T
D
---
E
L
F
T
V
R
S
S
----
D
-----
Q
A
W
T
C
Q
K
L
I
V
T
T
G
G
---------
K
S
Y
P
------------------
S
T
---------
G
S
T
G
F
G
H
D
I
A
R
H
F
K
-
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
D
F
P
----
H
K
A
L
Q
G
I
S
L
D
D
V
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
L
S
S
F
V
---------
K
----
G
-----
G
E
T
I
Y
--
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
---
H
--
R
E
K
S
L
K
N
C
--
L
K
I
L
L
P
E
R
I
A
D
F
F
T
-
Q
-----
P
F
----
P
E
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
T
L
E
-----
S
------
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
--
I
N
A
--
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
S
--------
22
PsiBlast_CBE
78.20
45%
-105
- C3 -
4CNJ
1
?
D:
[4-387]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
-
K
L
A
G
T
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
N
-----
G
------
N
L
D
D
L
M
A
G
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
------
D
---------
H
------
G
R
---------------------
V
---------
F
-----------------
P
V
-----
T
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
-
N
T
E
I
V
S
V
K
--
K
-
T
D
---
E
L
F
T
V
R
S
S
----
D
-----
Q
A
W
T
C
Q
K
L
I
V
T
T
G
G
---------
K
S
Y
P
------------------
S
T
---------
G
S
T
G
F
G
H
D
I
A
R
H
F
K
-
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
D
F
P
----
H
K
A
L
Q
G
I
S
L
D
D
V
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
L
S
S
F
V
---------
K
----
G
-----
G
E
T
I
Y
--
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
---
H
--
R
E
K
S
L
K
N
C
--
L
K
I
L
L
P
E
R
I
A
D
F
F
T
-
Q
-----
P
F
----
P
E
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
T
L
E
-----
S
------
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
--
I
N
A
--
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
S
--------
2
PsiBlast_PDB
77.94
45%
-107
- C3 -
4CNJ
1
?
A:
[4-387]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
-
K
L
A
G
T
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
N
-----
G
------
N
L
D
D
L
M
A
G
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
------
D
---------
H
------
G
R
---------------------
V
---------
F
-----------------
P
V
-----
T
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
-
N
T
E
I
V
S
V
K
--
K
-
T
D
---
E
L
F
T
V
R
S
S
----
D
-----
Q
A
W
T
C
Q
K
L
I
V
T
T
G
G
---------
K
S
Y
P
------------------
S
T
---------
G
S
T
G
F
G
H
D
I
A
R
H
F
K
-
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
D
F
P
----
H
K
A
L
Q
G
I
S
L
D
D
V
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
L
S
S
F
V
---------
K
----
G
-----
G
E
T
I
Y
--
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
---
H
--
R
E
K
S
L
K
N
C
--
L
K
I
L
L
P
E
R
I
A
D
F
F
T
-
Q
-----
P
F
----
P
E
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
T
L
E
-----
S
------
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
--
I
N
A
--
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
S
--------
23
PsiBlast_CBE
77.76
45%
-106
- C3 -
4CNJ
1
?
C:
[4-387]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
-
K
L
A
G
T
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
N
-----
G
------
N
L
D
D
L
M
A
G
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
------
D
---------
H
------
G
R
---------------------
V
---------
F
-----------------
P
V
-----
T
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
-
N
T
E
I
V
S
V
K
--
K
-
T
D
---
E
L
F
T
V
R
S
S
----
D
-----
Q
A
W
T
C
Q
K
L
I
V
T
T
G
G
---------
K
S
Y
P
------------------
S
T
---------
G
S
T
G
F
G
H
D
I
A
R
H
F
K
-
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
D
F
P
----
H
K
A
L
Q
G
I
S
L
D
D
V
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
L
S
S
F
V
---------
K
----
G
-----
G
E
T
I
Y
--
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
---
H
--
R
E
K
S
L
K
N
C
--
L
K
I
L
L
P
E
R
I
A
D
F
F
T
-
Q
-----
P
F
----
P
E
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
T
L
E
-----
S
------
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
--
I
N
A
--
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
S
--------
24
PsiBlast_CBE
77.69
45%
-106
- C3 -
4CNJ
1
?
B:
[4-387]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
-
K
L
A
G
T
G
G
G
R
C
-
N
-
V
------------
T
-
N
-
N
-----
G
------
N
L
D
D
L
M
A
G
-
I
-----
P
------
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
------
D
---------
H
------
G
R
---------------------
V
---------
F
-----------------
P
V
-----
T
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
-
N
T
E
I
V
S
V
K
--
K
-
T
D
---
E
L
F
T
V
R
S
S
----
D
-----
Q
A
W
T
C
Q
K
L
I
V
T
T
G
G
---------
K
S
Y
P
------------------
S
T
---------
G
S
T
G
F
G
H
D
I
A
R
H
F
K
-
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
D
F
P
----
H
K
A
L
Q
G
I
S
L
D
D
V
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
----
P
--
A
A
L
R
L
S
S
F
V
---------
K
----
G
-----
G
E
T
I
Y
--
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
---
H
--
R
E
K
S
L
K
N
C
--
L
K
I
L
L
P
E
R
I
A
D
F
F
T
-
Q
-----
P
F
----
P
E
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
T
L
E
-----
S
------
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
--
I
N
A
--
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
S
--------
128
HHSearch
67.65
31%
-92
- C2 -
3V76
1
?
A:
[28-417]
------------------------------------------------------------------------------------------------------------------------------
Q
D
V
V
I
I
G
A
G
A
A
G
M
M
C
A
I
E
A
G
K
R
G
R
R
V
L
V
I
D
H
A
R
A
P
G
E
-
K
I
R
I
S
G
G
G
R
C
-
N
-
F
------------
T
-
N
I
H
-----
A
------
S
P
R
N
F
L
---------
S
------
G
------
N
P
H
F
C
K
S
A
L
A
R
Y
R
P
Q
D
F
V
A
L
V
E
R
H
G
I
G
W
H
E
K
------
T
---------
L
------
G
Q
---------------------
L
---------
F
-----------------
C
------
D
H
S
A
K
D
I
I
R
M
L
M
A
E
M
K
E
A
G
V
Q
L
R
L
-
E
T
S
I
G
E
V
E
--
R
-
T
A
---
S
G
F
R
V
T
T
S
----
A
--
G
---
T
V
D
A
A
S
L
V
V
A
S
G
G
---------
K
S
I
P
------------------
K
M
---------
G
A
T
G
L
A
Y
R
I
A
E
Q
F
G
-
L
P
V
V
E
T
R
P
A
L
V
P
L
T
L
D
Q
A
Q
L
A
K
L
G
A
L
A
G
V
A
A
D
A
E
---
A
R
F
--
G
--
K
A
A
F
R
E
A
V
L
I
T
H
R
G
L
S
G
----
P
--
A
I
L
Q
I
S
S
Y
W
-
R
E
G
-----------------
E
E
I
V
--
L
R
L
M
P
D
I
D
I
A
S
I
L
K
---
G
M
R
R
A
---
N
--
G
R
Q
A
V
Q
T
A
--
L
A
D
I
L
P
R
R
L
A
Q
F
F
A
-
D
-----
E
A
K
L
T
G
-
R
M
L
A
D
L
S
D
K
T
I
D
A
L
A
S
S
I
Q
V
W
A
V
K
P
A
G
S
E
G
Y
R
T
A
E
V
T
L
G
G
V
D
T
-
R
A
L
D
S
R
T
M
Q
-----
A
------
K
E
V
P
G
L
Y
F
V
G
E
C
V
-
D
--
V
T
G
--
W
L
--
G
G
Y
N
F
Q
W
A
W
A
S
G
F
V
A
G
Q
D
V
------
4
PsiBlast_PDB
67.50
30%
-95
- C2 -
2GQF
2
Y933_HAEIN
A:
[8-397]
---------------------------------------------------------------------------------------------------------------------------------
I
I
I
G
A
G
A
A
G
L
F
C
A
A
Q
L
A
K
L
G
K
S
V
T
V
F
D
N
G
K
K
I
G
R
-
K
I
L
M
S
G
G
G
F
C
-
N
-
F
------------
T
-
N
-
L
-----
E
VT----
P
A
H
----
Y
-
L
-----
S
------
Q
------
N
P
H
F
V
K
S
A
L
A
R
Y
T
N
W
D
F
I
S
L
V
A
E
Q
G
I
T
Y
H
E
K
------
E
---------
L
------
G
Q
---------------------
L
---------
F
------------------
C
-----
D
E
G
A
E
Q
I
V
E
M
L
K
S
E
C
D
K
Y
G
A
K
I
L
L
-
R
S
E
V
S
Q
V
E
R
I
Q
-
N
D
--
E
K
V
R
F
V
L
Q
V
----
N
--
S
--
T
Q
W
Q
C
K
N
L
I
V
A
T
G
G
---------
L
S
M
P
------------------
G
L
---------
G
A
T
P
F
G
Y
Q
I
A
E
Q
F
G
-
I
P
V
I
P
P
R
A
S
L
V
P
F
T
Y
R
E
T
D
K
-
F
L
T
A
L
S
G
I
S
L
-
P
V
T
I
T
A
L
C
G
K
-----
S
F
Y
N
Q
L
L
F
T
H
R
G
I
S
G
----
P
--
A
V
L
Q
I
S
N
Y
---------
W
Q
----
P
-----
T
E
S
V
E
--
I
D
L
L
P
N
H
N
V
E
E
---
E
I
N
Q
A
K
Q
S
---
S
--
P
K
Q
M
L
K
T
I
--
L
V
R
L
L
P
K
K
L
V
E
L
W
I
-
E
-----
Q
G
I
V
Q
D
E
V
-
I
A
N
I
S
K
V
R
V
K
N
L
V
D
F
I
H
H
W
E
F
T
P
N
G
T
E
G
Y
R
T
A
E
V
T
M
G
G
V
D
T
-
K
V
I
S
S
K
T
M
E
-----
S
------
N
Q
V
S
G
L
Y
F
I
G
E
V
L
-
D
--
V
T
G
--
W
L
--
G
G
Y
N
F
Q
W
A
W
-----
S
S
A
Y
A
C
A
L
S
--
129
HHSearch
66.55
31%
-91
- C2 -
2GQF
2
Y933_HAEIN
A:
[4-401]
-----------------------------------------------------------------------------------------------------------------------------
Y
S
E
N
I
I
I
G
A
G
A
A
G
L
F
C
A
A
Q
L
A
K
L
G
K
S
V
T
V
F
D
N
G
K
K
I
G
R
-
K
I
L
M
S
G
G
G
F
C
-
N
-
F
------------
T
-
N
L
E
-----
V
------
T
P
A
H
Y
L
S
---------------
Q
------
N
P
H
F
V
K
S
A
L
A
R
Y
T
N
W
D
F
I
S
L
V
A
E
Q
G
I
T
Y
H
E
K
------
E
---------
L
------
G
Q
---------------------
L
---------
F
-----------------
C
D
------
E
G
A
E
Q
I
V
E
M
L
K
S
E
C
D
K
Y
G
A
K
I
L
L
-
R
S
E
V
S
Q
V
E
--
R
-
I
Q
ND
E
K
V
R
F
V
L
Q
V
----
N
--
S
--
T
Q
W
Q
C
K
N
L
I
V
A
T
G
G
---------
L
S
M
P
------------------
G
L
---------
G
A
T
P
F
G
Y
Q
I
A
E
Q
F
G
-
I
P
V
I
P
P
R
A
S
L
V
P
F
T
Y
R
E
T
D
K
-
F
L
T
A
L
S
G
I
S
L
P
---
V
T
I
T
A
L
C
G
---
K
S
F
Y
N
Q
L
L
F
T
H
R
G
I
S
G
----
P
--
A
V
L
Q
I
S
N
Y
W
-
Q
P
T
-----------------
E
S
V
E
--
I
D
L
L
P
N
H
N
V
E
E
E
I
N
---
Q
A
K
Q
S
---
S
--
P
K
Q
M
L
K
T
I
--
L
V
R
L
L
P
K
K
L
V
E
L
W
I
-
E
-----
Q
-
G
I
V
Q
D
E
V
I
A
N
I
S
K
V
R
V
K
N
L
V
D
F
I
H
H
W
E
F
T
P
N
G
T
E
G
Y
R
T
A
E
V
T
M
G
G
V
D
T
-
K
V
I
S
S
K
T
M
E
-----
S
------
N
Q
V
S
G
L
Y
F
I
G
E
V
L
-
D
--
V
T
G
--
W
L
--
G
G
Y
N
F
Q
W
A
W
S
S
A
Y
A
C
A
L
S
I
S
R
Q
---
5
PsiBlast_PDB
62.19
28%
-84
- C2 -
3V76
1
?
A:
[46-414]
------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
R
G
R
R
V
L
V
I
D
H
A
R
A
P
G
E
-
K
I
R
I
S
G
G
G
R
C
-
N
-
F
------------
T
-
N
-
I
-----
H
------
A
S
P
R
--
N
F
-
L
-----
S
------
G
------
N
P
H
F
C
K
S
A
L
A
R
Y
R
P
Q
D
F
V
A
L
V
E
R
H
G
I
G
W
H
E
K
------
T
---------
L
------
G
Q
---------------------
L
---------
F
------------------
C
-----
D
H
S
A
K
D
I
I
R
M
L
M
A
E
M
K
E
A
G
V
Q
L
R
L
-
E
T
S
I
G
E
V
E
--
R
-
T
A
--
S
G
F
R
-
V
T
T
S
----
A
--
G
--
T
-
V
D
A
A
S
L
V
V
A
S
G
G
---------
K
S
I
P
------------------
K
M
---------
G
A
T
G
L
A
Y
R
I
A
E
Q
F
G
-
L
P
V
V
E
T
R
P
A
L
V
P
L
T
----
L
D
-
Q
A
Q
L
A
K
L
G
A
L
A
G
V
A
A
D
A
E
A
R
F
G
K
A
A
F
R
E
A
--
V
L
I
T
H
R
G
L
S
G
----
P
--
A
I
L
Q
I
S
S
Y
--
W
R
E
G
E
----------------
E
I
V
--
L
R
L
M
P
D
I
D
I
A
S
I
L
K
G
M
R
R
---
A
---
N
--
G
R
Q
A
V
Q
T
A
--
L
A
D
I
L
P
R
R
L
A
Q
F
F
A
-
D
-----
E
A
K
L
T
G
R
M
-
L
A
D
L
S
D
K
T
I
D
A
L
A
S
S
I
Q
V
W
A
V
K
P
A
G
S
E
G
Y
R
T
A
E
V
T
L
G
G
V
D
T
-
R
A
L
D
S
R
T
M
Q
-----
A
------
K
E
V
P
G
L
Y
F
V
G
E
C
V
-
D
--
V
T
G
--
W
L
--
G
G
Y
N
F
Q
W
A
W
A
S
G
F
V
A
G
---------
152
Fugue
58.54
22%
-63
- C2 -
1QJD
8
FRDA_SHEFR
A:
[1-568]
ADN
L
A
E
F
H
V
QNQECDSCHTPDGELSNDSL
T
Y
E
N
T
Q
C
V
S
C
HGT
L
A
E
V
A
E
T
T
KHEHYNAHASHFPGEVACTSCHSAH
E
K
S
M
V
YCDSCHSFDFNMPYAK
K
W
L
R
D
E
P
T
IAELAKDK
S
E
R
Q
A
A
L
A
SAPH
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
-
N
A
K
L
A
A
G
G
M
N
-
A
-
A
WT
D
Q
Q
K
A
K
K
I
T
D
S
-
P
-
E
-----
L
------
M
F
E
D
T
M
K
G
-
G
-----
Q
------
N
------
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
GA
S
---------
V
------
N
R
---------------------
A
---------
H
R
P
T
--------------
G
G
-----
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
-
N
T
R
G
I
E
V
L
--
K
D
D
K
--
G
T
V
K
G
I
L
V
K
G
MYK
G
--
Y
--
Y
W
V
K
A
D
A
V
I
L
A
T
G
G
FAKN
N
E
R
V
A
K
L
D
P
------------------
S
L
KGFISTNQP
G
A
V
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
----
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
----
Q
--
T
G
K
S
A
Y
L
I
F
-
D
D
S
V
R
K
S
L
S
--------------
K
--
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
---
E
--------
G
I
--
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
-
L
-----
V
S
S
G
K
D
T
D
F
E
R
P
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
---------
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
-----
K
------
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
--
V
H
G
--
A
N
RL
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
--
151
Fugue
55.74
21%
-56
- C2 -
1JRX
7
FRDA_SHEFR
A:
[1-568]
ADN
L
A
E
F
H
V
QNQECDSCHTPDGELSNDSL
T
Y
E
N
T
Q
C
V
S
C
HGT
L
A
E
V
A
E
T
T
KHEHYNAHASHFPGEVACTSCHSAH
E
K
S
M
V
YCDSCHSFDFNMPYAK
K
W
L
R
D
E
P
T
IAELAKD
K
S
E
R
Q
A
A
L
A
SAPH
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
-
N
A
K
L
A
A
G
G
M
N
-
A
-
A
WT
D
Q
Q
K
A
K
K
I
T
D
S
-
P
-
E
-----
L
------
M
F
E
D
T
M
K
G
-
G
-----
Q
------
N
------
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
------
G
M
M
G
GASVNR
A
------
H
R
---------------------
P
---------
T
-----------------
G
G
-----
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
N
T
R
G
I
E
V
L
K
--
D
-
D
K
--
G
T
V
K
G
I
L
V
K
G
MYK
G
--
Y
--
Y
W
V
K
A
D
A
V
I
L
A
T
G
G
FAKN
N
E
R
V
A
K
L
D
P
------------------
S
L
KGFISTNQP
G
A
V
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
----
G
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
A
D
K
A
S
A
A
I
L
A
----
Q
--
T
G
K
S
A
Y
L
I
F
-
D
D
S
V
R
K
S
L
S
--------------
K
--
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
---
E
--------
G
I
--
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
-
L
-----
V
S
S
G
K
D
T
D
F
E
R
P
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
---------
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
-----
K
------
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
--
V
H
G
--
A
N
RL
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
--
130
HHSearch
53.97
18%
-68
- C2 -
2H88
4
SDHA_CHICK
A:
[18-433]
-----------------------------------------------------------------------------------------------------------------------------
E
F
D
A
V
V
V
G
A
G
G
A
G
L
R
A
A
F
G
L
S
E
A
G
F
N
T
A
C
V
T
K
L
F
P
T
R
S
-
H
T
V
A
A
Q
G
G
I
N
A
A
-
L
------------
G
-
N
M
E
D----
D
------
N
W
R
W
H
F
Y
D
-
T
-----
V
K
G
S
DWL
G
------
D
Q
D
A
I
H
Y
M
T
E
Q
--
A
P
A
A
V
I
E
L
E
N
Y
G
M
P
F
S
R
T
------
E
---------
E
------
G
K
---------------------
I
---------
Y
Q
R
A
F
G
GQSLQFGKGGQA
H
R
C
C
C
VA
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
S
L
R
Y
D
T
S
Y
F
V
-
E
Y
F
A
L
D
L
L
--
M
-
E
N
--
G
E
C
R
G
V
I
A
L
CIE-
D
--
G
T
I
H
R
F
R
A
K
N
T
V
I
A
T
G
G
---------
Y
G
R
T
YFSCTS------------
A
H
---------
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
----
I
T
---
E
G
C
R
-
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
KDLA
S
--
R
D
V
V
S
R
S
M
T
-
I
E
I
R
E
--
G
R
GCGP
E
-----
K
D
H
V
Y
--
L
Q
L
-
H
H
L
P
P
Q
Q
L
A
T
---
R
L
P
-------------------------
G
I
S
E
T
A
M
-
I
-----
F
A
G
V
D
V
T
K
-------
E
------------
P
I
P
V
L
P
T
V
H
Y
-----
N
M
G
G
I
P
T
-
N
Y
K
G
-
Q
V
I
T
H
V
NG
E
D
------
K
V
V
P
G
L
Y
A
C
G
E
A
A
-
S
AS
V
H
G
AN
R
L
--
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
-
138
HHSearch
50.09
20%
-76
- C2 -
2E5V
2
NADB_SULTO
A:
[1-371]
-------------------------------------------------------------------------------------------------------------------------------
M
I
Y
I
I
G
S
G
I
A
G
L
S
A
G
V
A
L
R
R
A
G
K
K
V
T
L
I
S
K
R
I
-
D
G
G
-
S
T
P
I
A
K
G
G
V
A
-
A
-
S
------------
V
-
G
S
D
-----
D
------
S
P
E
L
H
A
Q
D
-
T
-----
I
R
V
G
DGL
C
------
D
V
K
T
V
N
Y
V
T
S
--
E
A
K
N
V
I
E
T
F
E
S
W
G
F
E
F
E
E
D
------
L
R
L
E
------
G
------
G
H
---------------------
T
---------
K
-----------------
R
R
V
L
H
R
T
D
E
T
G
R
E
I
F
N
F
L
L
K
L
A
R
E
E
G
I
P
I
I
E
-
D
-
R
L
V
E
I
R
--
V
-
K
D
--
G
K
V
T
G
F
V
T
E
K---
R
--
G
--
L
V
E
D
V
D
K
L
V
L
A
T
G
G
---------
Y
S
Y
L
YEYSST------------
Q
S
---------
T
N
I
G
D
G
M
A
I
A
F
K
A
G
-
T
I
L
A
D
M
E
F
V
Q
F
H
P
T
V
T
S
L
D
G
--
E
V
F
L
L
T
-------
E
T
L
R
-
G
E
G
A
Q
I
I
N
E
N
G
E
R
F
L
F
N
Y
D
K
R
G
----
E
LA
P
R
D
I
L
S
R
A
I
-
Y
I
E
M
L
K
-
G
------------
H
K
V
F
--
I
D
L
-
S
K
I
E
--
D
F
E
R
---
K
F
------------------------
P
V
--
V
A
K
Y
L
-
A
-----
R
H
G
H
N
Y
K
V
--------------------
K
I
P
I
F
P
A
A
H
F
-----
V
D
G
G
I
R
V
-
N
I
R
G
-
E
S
---------------
N
I
V
N
L
Y
A
I
G
E
V
S
-
D
SG
L
H
G
AN
R
L
--
A
S
N
S
L
L
E
G
L
V
F
G
I
N
L
P
R
Y
V
D
S
S
---
135
HHSearch
50.09
22%
-49
- C2 -
1Y0P
5
FRDA_SHEFR
A:
[126-568]
-----------------------------------------------------------------------------------------------------------------------------
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
-
N
A
K
L
A
A
G
G
M
N
-
A
A
W
------------
T
-
D
Q
Q
-----
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
-
T
-----
M
------
K
G
G
QNIN
D
P
A
L
V
K
V
L
S
S
--
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
------
G
---------
M
M
G
GASV
N
R
---------------------
A
---------
H
R
----------------
P
T
GG---
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
I
D
L
R
M
-
N
T
R
G
I
E
V
L
--
K
-
D
D
K-
G
T
V
K
G
I
L
V
K
G
M--
Y
K
G
Y
--
Y
W
V
K
A
D
A
V
I
L
A
T
G
G
---------
F
A
K
N
N
E
R
V
A
K
L
DPSLKGFISTN
Q
P
---------
G
A
V
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
--
V
M
V
T
E
A
V
R
----------
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
----------
D
K
A
S
A
A
I
-
L
A
Q
T
---
G
------------
K
S
A
Y
--
L
I
F
-
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
---
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
-
R
Y
N
S
L
V
S
S
G
K
D
T
D
-----
F
E
R
P
---
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
--
G
V
H
H
T
M
G
G
V
M
I
-
D
T
K
A
-
E
V
M
N
-----
A
KK----
Q
V
I
P
G
L
Y
G
A
G
E
V
T
-
G
G-
V
H
G
AN
R
L
--
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
--
134
HHSearch
50.00
21%
-61
- C2 -
2WDQ
4
SDHA_ECOLI
A:
[7-424]
-----------------------------------------------------------------------------------------------------------------------------
E
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
G
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
-
A
-
L
------------
G
-
N
-
T
HE---
D
------
N
W
E
W
H
M
Y
D
T
V
K
G
S
DY
I
------
G
------
D
Q
D
A
I
E
Y
M
C
K
T
--
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
------
D
---------
D
------
G
R
---------------------
I
---------
Y
Q
R
P
F
G
GQSKNFGG
E
Q
A
-
A
R
TAAAA
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
N
L
K
N
H
T
T
I
F
S
-
E
W
Y
A
L
D
L
V
--
K
-
N
Q
D-
G
A
V
V
G
C
T
A
L
CIE-
T
--
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
---------
A
G
R
I
YQSTTN------------
A
H
---------
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
G
--
V
L
V
T
E
G
C
R
----------
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
N
A
KDLA
G
--
R
D
V
V
A
R
S
I
M
-
I
E
I
R
E
--
G
R
----
G
C
D
G
PW
G
P
H
A
K
--
L
K
L
-
D
H
L
G
K
E
V
L
E
S
---------------------
R
------
L
P
G
-
I
-
L
E
L
S
R
T
-----
F
A
H
V
D
P
V
K
-------
E
------------
P
I
P
V
I
P
T
C
H
Y
-----
M
M
G
G
I
P
T
-
K
V
T
G
-
Q
A
L
T
-----
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
VS
V
H
G
AN
R
L
--
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
H
L
Q
E
S
I
A
-
131
HHSearch
48.40
20%
-66
* C2 *
2BS2
3
FRDA_WOLSU
A:
[5-429]
-----------------------------------------------------------------------------------------------------------------------------
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
G
L
S
T
I
V
L
S
L
I
P
V
K
R
S
-
H
S
A
A
A
Q
G
G
M
Q
-
A
-
S
------------
L
G
N
-
S
KMSDG
D
------
N
E
D
L
H
F
M
D
-
T
-----
V
K
G
S
DWG
C
------
D
Q
K
V
A
R
M
F
V
N
T
--
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
------
H
---------
K
------
G
D
R
MAIINAQK
T
T
I
T
E
E
DFRHG
L
I
H
S
R
DFGGTK
K
-----------------
W
R
T
C
Y
TA
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
D
-
R
K
E
A
I
A
L
I
--
H
-
Q
D
--
G
K
C
Y
G
A
V
V
R
DLV-
T
--
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
---------
Y
G
R
I
YKNTTN------------
A
V
---------
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
----
S
G
I
L
L
T
E
G
-------
C
R
-
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
P
E
K
KEL-
A
--
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
--
G
K
----
G
V
Q
S
PY
G
Q
H
L
W
--
L
D
I
-
S
I
L
G
R
K
H
I
E
T
---
N
L
-------------------------
R
D
V
-
Q
E
I
C
-
E
Y
----
F
A
G
I
D
P
A
E
-------------------
K
W
A
P
V
L
P
M
Q
H
Y
S
-----
M
G
G
I
R
T
-
D
Y
R
G
-
E
A
---------------
K
L
K
G
L
F
S
A
G
E
A
A
-
C
WD
M
H
G
FN
R
L
--
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
-