@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1923: (2016-03-30 )
MKLITNKQGLVGAITVPGDKSMSHRSIMFGAIAEGKTVIRHFLRADDCLGTIKAFKALGVKIEETDEEIIVHGTGFDGLKQADGPLDIGNSGTTIRLMMGILAGRDFDTVILGDESIAKRPMNRVMLPLQQMGAKMHGKDGSEFAPITITGKQSLKRMEYHMPVASAQVKSAIIFAALQAEGETIIHEKEKTRDHTEHMIRQFGGEIEMDGLTIRVKGGQKFTGQEMTVPGDVSSAAFFIVAGLITPGSEIELTHVGLNPTRTGIFDVVKQMGGSLVVKDSSRSTGKLAGTVVVKTSKLKGTEIDGDIIPRLIDEIPVIALLATQAEGTTIIKDAAELKVKETNRIDAVATELNKMGADITPTEDGLIIHGKTPLHAANVTSYGDHRIGMMLQIAALLVEEGDVELERPEAVSVSYPTFFEDIRSLLK
Atome Classification :
(31 SA)
.........10........20........30........40........50........60.----......--.70........80.......--.90........100.......110.......120.......130.......140.......150.......160.......170.......180.......-----190.......200...----....210-----.-......220...-....230.......240.......250.......260...--....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.------.------..-..-.380.......390.....-..400.......410.......420......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKLITNKQG
L
V
G
A
I
TVPGDKSMSHR
S
I
M
F
G
AIAE
G
K
T
V
I
R
H
F
L
R
A
D
D
C
L
G
T
I
K
A
F
K
A
LG
V
K
I
----EETDE
E
--
I
I
V
HGTGFDGLKQADGPLDI--GNSG
T
T
I
R
L
M
M
G
I
LAGRD
F
D
T
V
I
LG
D
E
S
I
A
KR
P
M
N
R
V
M
L
P
L
Q
Q
M
G
A
KMHGKDGS
E
F
A
P
I
T
IT
G
K
Q
S
L
K
R
M
E
Y
HMPV
A
S
A
Q
V
K
S
A
I
I
F
A
A
LQAEG
E
T
II
H
E
K
-----
E
KT
R
D
H
T
E
H
M
I
R
Q
FGG----
E
I
E
MD
G
L
-----
T
-
I
R
VKGGQKFTGQ-EMTVPGDVS
S
A
A
F
F
I
V
A
G
LITPG
S
E
I
E
L
T
H
VGLNPTR
T
G
I
--
F
D
V
V
K
QMG
G
S
L
V
V
KDSSRSTG
K
L
A
G
T
V
V
V
K
TSKLKGTEID
G
D
I
I
P
R
L
I
D
EI
P
V
I
A
L
L
ATQAEG
T
T
I
IKD
A
A
E
L
K
V
KETNR
I
D
A
V
A
T
E
L
N
KMGADITPTED
G
L
I
I
HGKT------P------
L
H
-
A
A-NVTSYGD
H
R
I
G
M
M
L
Q
I
A
A
L
-
L
VEEGD
V
E
LERP
E
A
V
SVSY
P
T
F
F
E
D
I
R
S
LLK
29
PsiBlast_CBE
96.57
56%
-112
- C8 -
3RMT
8
AROA1_BACHD
B:
[8-430]
--
V
I
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
----
E
Q
A
E
E
R
--
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
--
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
Q
-
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
-----
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
----
N
I
E
K
D
G
L
-----
T
-
V
S
I
E
G
G
Q
M
L
T
G
Q
-
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
--
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
------
P
------
L
K
-
G
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
--
2
PsiBlast_PDB
96.26
56%
-114
- C8 -
1RF5
-
AROA_STRPN
A:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
23
PsiBlast_CBE
95.71
56%
-105
- C8 -
1RF6
2
AROA_STRPN
B:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
4
PsiBlast_PDB
95.67
56%
-112
- C8 -
3RMT
9
AROA1_BACHD
A:
[8-430]
--
V
I
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
----
E
Q
A
E
E
R
--
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
--
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
Q
-
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
-----
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
----
N
I
E
K
D
G
L
-----
T
-
V
S
I
E
G
G
Q
M
L
T
G
Q
-
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
--
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
------
P
------
L
K
-
G
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
--
3
PsiBlast_PDB
95.18
56%
-105
- C8 -
1RF6
2
AROA_STRPN
A:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
44
HHSearch
95.06
56%
-111
- C8 -
3RMT
9
AROA1_BACHD
A:
[7-432]
-
T
V
I
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
----
E
Q
A
E
E
R
--
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
--
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
-
Q
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
-----
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
----
N
I
E
K
D
G
L
-----
T
-
V
S
I
E
G
G
Q
M
L
T
G
Q
-
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
--
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
------
P
------
L
K
G
G
V
-
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
-
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
25
PsiBlast_CBE
95.05
56%
-105
- C8 -
1RF4
1
AROA_STRPN
C:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
28
PsiBlast_CBE
95.03
56%
-107
- C8 -
3RMT
6
AROA1_BACHD
C:
[8-430]
--
V
I
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
----
E
Q
A
E
E
R
--
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
--
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
Q
-
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
-----
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
----
N
I
E
K
D
G
L
-----
T
-
V
S
I
E
G
G
Q
M
L
T
G
Q
-
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
--
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
L
K
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
------
P
------
L
K
-
G
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
--
26
PsiBlast_CBE
95.01
56%
-104
- C8 -
1RF4
1
AROA_STRPN
B:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
22
PsiBlast_CBE
94.88
56%
-103
- C8 -
1RF6
2
AROA_STRPN
C:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
21
PsiBlast_CBE
94.88
56%
-103
- C8 -
1RF6
2
AROA_STRPN
D:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
24
PsiBlast_CBE
94.77
56%
-106
- C8 -
1RF4
1
AROA_STRPN
D:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
1
PsiBlast_PDB
94.61
56%
-105
- C8 -
1RF4
1
AROA_STRPN
A:
[1-425]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
-
41
HHSearch
94.58
56%
-104
- C8 -
1RF6
2
AROA_STRPN
A:
[1-426]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
A
-
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
27
PsiBlast_CBE
93.71
56%
-107
- C8 -
3RMT
3
AROA1_BACHD
D:
[8-430]
--
V
I
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
----
E
Q
A
E
E
R
--
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
--
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
Q
-
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
-----
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
----
N
I
E
K
D
G
L
-----
T
-
V
S
I
E
G
G
Q
M
L
T
G
Q
-
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
--
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
------
P
------
L
K
-
G
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
--
5
PsiBlast_PDB
92.89
52%
-111
- C8 -
4N3P
11
?
A:
[3-426]
-
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
S
S
I
S
V
L
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
----
E
D
K
D
G
V
--
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
--
G
N
S
G
A
S
I
V
A
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
N
S
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
-----
E
Y
T
S
N
H
T
E
D
M
L
Q
Q
F
G
G
----
H
L
S
V
D
G
K
-----
K
-
I
T
V
Q
G
P
Q
K
L
T
G
Q
-
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
E
E
T
L
T
G
I
--
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
--
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
------
A
------
L
H
-
G
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
----
P
S
F
F
D
D
L
E
S
L
I
-
6
PsiBlast_PDB
91.61
43%
-110
- C8 -
3ROI
13
AROA_COXBU
A:
[12-423]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
----
Q
V
I
E
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
--
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
-----
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
----
T
L
Q
---------
S
-
I
C
V
S
G
G
G
K
L
K
A
N
-
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
--
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
N
E
-
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------------
L
E
-
G
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
-
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
-------
31
PsiBlast_CBE
90.12
43%
-99
- C8 -
4EGR
3
AROA_COXBU
E:
[12-423]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
----
Q
V
I
E
D
E
NI
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
--
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
-----
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
----
T
L
Q
K
--
Q
-----
S
-
I
C
V
S
G
G
G
K
L
K
A
N
-
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
--
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
--
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------------
L
E
-
G
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
-
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
-------
38
PsiBlast_CBE
90.00
43%
-108
- C8 -
3ROI
9
AROA_COXBU
B:
[12-423]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
----
Q
V
I
E
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
--
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
-----
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
----
T
L
Q
K
D
K
Q
-----
S
-
I
C
V
S
G
G
G
K
L
K
A
N
-
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
--
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
-
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------------
L
E
-
G
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
-
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
-------
30
PsiBlast_CBE
89.63
43%
-98
- C8 -
4EGR
3
AROA_COXBU
F:
[12-423]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
----
Q
V
I
E
D
E
NI
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
--
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
-----
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
----
T
L
Q
K
--
Q
-----
S
-
I
C
V
S
G
G
G
K
L
K
A
N
-
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
--
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
--
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------------
L
E
-
G
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
-
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
-------
14
PsiBlast_PDB
87.06
39%
-90
- C8 -
2PQC
1
AROA_AGRSC
A:
[10-433]
------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
----
R
K
E
G
D
T
--
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
--
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
-----
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
R
----
T
-
I
R
L
E
G
R
G
K
L
T
G
Q
-
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
--
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
DGKGLG
N
------
A
S
-
G
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
-------
17
PsiBlast_PDB
86.97
39%
-88
- C8 -
2GGA
2
AROA_AGRSC
A:
[15-438]
------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
----
R
K
E
G
D
T
--
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
--
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
-----
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
R
----
T
-
I
R
L
E
G
R
G
K
L
T
G
Q
-
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
--
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
DGKGLG
N
------
A
S
-
G
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
-------
16
PsiBlast_PDB
86.55
39%
-88
- C8 -
2GG6
2
AROA_AGRSC
A:
[15-438]
------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
----
R
K
E
G
D
T
--
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
--
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
-----
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
R
----
T
-
I
R
L
E
G
R
G
K
L
T
G
Q
-
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
--
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
DGKGLG
N
------
A
S
-
G
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
-------
9
PsiBlast_PDB
86.45
43%
-94
- C8 -
4ZND
5
AROA_COXBU
A:
[12-423]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
----
Q
V
I
E
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
--
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
-----
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
----
T
L
Q
K
D
K
Q
-----
S
-
I
C
V
S
G
G
G
K
L
K
A
N
-
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
--
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------------
L
E
-
G
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
-
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
-------
42
HHSearch
86.44
39%
-92
- C8 -
2PQC
1
AROA_AGRSC
A:
[6-440]
--
T
A
R
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
----
R
K
E
G
D
T
--
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
--
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
-----
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
----
N
L
T
V
E
T
D
ADG
V
R
T
-
I
R
L
E
G
R
G
K
L
T
G
Q
-
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
--
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
------
D
GKGLGN
A
S
-
G
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
-
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
11
PsiBlast_PDB
86.42
39%
-87
- C8 -
2PQD
1
AROA_AGRSC
A:
[10-433]
------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
----
R
K
E
G
D
T
--
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
--
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
-----
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
R
----
T
-
I
R
L
E
G
R
G
K
L
T
G
Q
-
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
--
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
DGKGLG
N
------
A
S
-
G
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
-------
13
PsiBlast_PDB
85.95
39%
-87
- C8 -
2PQB
1
AROA_AGRSC
A:
[10-433]
------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
----
R
K
E
G
D
T
--
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
--
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
-----
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
R
----
T
-
I
R
L
E
G
R
G
K
L
T
G
Q
-
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
--
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
DGKGLG
N
------
A
S
-
G
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
-------
12
PsiBlast_PDB
85.86
39%
-86
- C8 -
2GGD
2
AROA_AGRSC
A:
[15-438]
------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
----
R
K
E
G
D
T
--
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
--
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
-----
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
R
----
T
-
I
R
L
E
G
R
G
K
L
T
G
Q
-
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
--
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
DGKGLG
N
------
A
S
-
G
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
-------
18
PsiBlast_PDB
71.34
30%
-72
- C8 -
2QFQ
10
AROA_ECOLI
A:
[14-420]
-----------
G
T
I
N
L
P
G
S
K
S
V
S
N
R
A
L
L
L
A
A
L
A
H
G
K
T
V
L
T
N
L
L
D
S
D
D
V
R
H
M
L
N
A
L
T
A
L
G
V
S
Y
T
L
S
A
D
R
T
R
C
E
--
I
I
G
N
G
----
G
P
L
H
A
E
G
A
L
E
L
F
L
G
N
A
G
T
A
M
R
L
L
A
A
A
L
C
L
G
S
N
D
I
V
L
T
G
E
P
R
M
K
E
R
P
I
G
H
L
V
D
A
L
R
L
G
G
A
K
I
T
Y
L
E
Q
E
N
Y
P
P
L
R
L
Q
G
G
F
T
G
G
N
V
D
V
D
G
S
V
S
S
-
Q
F
L
T
A
L
L
M
T
A
P
L
A
P
E
D
T
V
I
R
I
K
GDLVS
K
P
Y
I
D
I
T
L
N
L
M
K
T
F
G
V
----
E
I
E
N
Q
H
Y
-----
Q
Q
F
V
V
K
G
G
Q
S
Y
Q
S
P
G
T
Y
L
V
E
G
D
A
S
S
A
S
Y
F
L
A
A
A
A
I
K
G
G
T
-
V
K
V
T
G
I
G
R
N
S
M
Q
G
D
I
R
F
A
D
V
L
E
K
M
G
A
T
I
C
W
G
D
D
Y
I
S
C
T
R
---------
G
E
L
N
A
I
D
M
D
M
N
H
I
P
---
D
A
A
M
T
I
A
T
A
A
L
F
A
K
G
T
T
T
L
R
N
I
Y
N
W
R
V
K
E
T
D
R
L
F
A
M
A
T
E
L
R
K
V
G
A
E
V
E
E
G
H
D
Y
I
R
I
T
P
P
E
------
K
------
L
N
-
F
A
-
E
I
A
T
Y
N
D
H
R
M
A
M
C
F
S
L
V
A
L
---
S
D
T
P
V
T
I
L
D
P
K
C
T
A
K
T
F
P
D
Y
F
E
Q
L
-----
20
PsiBlast_PDB
71.29
30%
-72
- C8 -
2QFS
12
AROA_ECOLI
A:
[14-420]
-----------
G
T
I
N
L
P
G
S
K
S
V
S
N
R
A
L
L
L
A
A
L
A
H
G
K
T
V
L
T
N
L
L
D
S
D
D
V
R
H
M
L
N
A
L
T
A
L
G
V
S
Y
T
L
S
A
D
R
T
R
C
E
--
I
I
G
N
G
----
G
P
L
H
A
E
G
A
L
E
L
F
L
G
N
A
G
T
A
M
R
S
L
A
A
A
L
C
L
G
S
N
D
I
V
L
T
G
E
P
R
M
K
E
R
P
I
G
H
L
V
D
A
L
R
L
G
G
A
K
I
T
Y
L
E
Q
E
N
Y
P
P
L
R
L
Q
G
G
F
T
G
G
N
V
D
V
D
G
S
V
S
S
-
Q
F
L
T
A
L
L
M
T
A
P
L
A
P
E
D
T
V
I
R
I
K
GDLVS
K
P
Y
I
D
I
T
L
N
L
M
K
T
F
G
V
----
E
I
E
N
Q
H
Y
-----
Q
Q
F
V
V
K
G
G
Q
S
Y
Q
S
P
G
T
Y
L
V
E
G
D
A
S
S
A
S
Y
F
L
A
A
A
A
I
K
G
G
T
-
V
K
V
T
G
I
G
R
N
S
M
Q
G
D
I
R
F
A
D
V
L
E
K
M
G
A
T
I
C
W
G
D
D
Y
I
S
C
T
R
---------
G
E
L
N
A
I
D
M
D
M
N
H
I
P
---
D
A
A
M
T
I
A
T
A
A
L
F
A
K
G
T
T
T
L
R
N
I
Y
N
W
R
V
K
E
T
D
R
L
F
A
M
A
T
E
L
R
K
V
G
A
E
V
E
E
G
H
D
Y
I
R
I
T
P
P
E
------
K
------
L
N
-
F
A
-
E
I
A
T
Y
N
D
H
R
M
A
M
C
F
S
L
V
A
L
---
S
D
T
P
V
T
I
L
D
P
K
C
T
A
K
T
F
P
D
Y
F
E
Q
L
-----
19
PsiBlast_PDB
71.23
30%
-73
- C8 -
2QFU
9
AROA_ECOLI
A:
[14-420]
-----------
G
T
I
N
L
P
G
S
K
S
V
S
N
R
A
L
L
L
A
A
L
A
H
G
K
T
V
L
T
N
L
L
D
S
D
D
V
R
H
M
L
N
A
L
T
A
L
G
V
S
Y
T
L
S
A
D
R
T
R
C
E
--
I
I
G
N
G
----
G
P
L
H
A
E
G
A
L
E
L
F
L
G
N
A
G
T
A
M
R
L
L
A
A
A
L
C
L
G
S
N
D
I
V
L
T
G
E
P
R
M
K
E
R
P
I
G
H
L
V
D
A
L
R
L
G
G
A
K
I
T
Y
L
E
Q
E
N
Y
P
P
L
R
L
Q
G
G
F
T
G
G
N
V
D
V
D
G
S
V
S
S
-
Q
F
L
T
A
L
L
M
T
A
P
L
A
P
E
D
T
V
I
R
I
K
GDLVS
K
P
Y
I
D
I
T
L
N
L
M
K
T
F
G
V
----
E
I
E
N
Q
H
Y
-----
Q
Q
F
V
V
K
G
G
Q
S
Y
Q
S
P
G
T
Y
L
V
E
G
D
A
S
S
A
S
Y
F
L
A
A
A
A
I
K
G
G
T
-
V
K
V
T
G
I
G
R
N
S
M
Q
G
D
I
R
F
A
D
V
L
E
K
M
G
A
T
I
C
W
G
D
D
Y
I
S
C
T
R
---------
G
E
L
N
A
I
D
M
D
M
N
H
I
P
---
D
A
A
M
T
I
A
T
A
A
L
F
A
K
G
T
T
T
L
R
N
I
Y
N
W
R
V
K
E
T
D
R
L
F
A
M
A
T
E
L
R
K
V
G
A
E
V
E
E
G
H
D
Y
I
R
I
T
P
P
E
------
K
------
L
N
-
F
A
-
E
I
A
T
Y
N
D
H
R
M
A
M
C
F
S
L
V
A
L
---
S
D
T
P
V
T
I
L
D
P
K
C
T
A
K
T
F
P
D
Y
F
E
Q
L
-----