@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1925: (2016-03-30 )
MKWKKSLAGLSSYKPGKREEEVMAELGLTKITKLSSNENPLGTSPKVAALQANSNVETEIYPDGWASSLRKEVTNFYQLEEEELIFTAGVDELIELLTRVLLDTTKNTVMATPTFVQYRQNALIEGAEVREIPLLTDGAHDLEGMLNAIDEKTTIVWICNPNNPTGNYIDLADIQAFLDKVPSDILVVLDEAYIEYVTPQPKKHEKLIRTYKNLIITRTFSKIYGLASARVGYGIADKEIINQLNIVRPPFNTTSIGQKLAIEAIKDQAFIEACRISNANGIKQYEAFAKRFEQVKLYPANGNFVLIDLGIEARTIFSYLEKNGYITRSGAALGFPTAVRITIGKEEENSAVIALLEKLL
Atome Classification :
(20 SA)
-----.........10........20........30........40.....-...50.....----..-.60........70......--.------.80-........90........100...-....110......-..120.......130.......140.......150-...--......160.......170.......180-.---......190......-.200---.-.---.-..-.-.-210.......220.......230....-.-..240..-.....250.......260--------......--..270..-.....280.......290..----.----..--..-300.......-310......-.-.320......-.-330..--....---.340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----M
K
W
K
K
S
LAGLSSYKPG
K
R
E
E
E
V
M
A
E
LG
L
T
K
I
T
KLSSNENPLGTSP
K
-
V
A
A
L
QANSNV----E
T
-
E
IYPD
G
W
A
S
S
L
R
K
E
V
T
N
F
Y
--Q------LEE-E
E
L
I
F
TA
G
V
D
E
L
I
E
L
L
T
R
V
L
L
DTT-KN
T
V
M-AT
P
T
F
V
Q
-
Y
R
Q
N
ALIEGAE
V
R
EIPLLTDG
A
H
D
L
E
G
M
L
N
AID---EK
T
--
T
I
V
W
I
CNPNNPTG
N
Y
I
D
L
A
D
I
Q
A
F
L
D
KVP-
S
---
D
I
L
V
V
L
D
E
A
Y
I
E
YVT-PQ
P
K
---
K
-
H
---
E
-
K
L
-
I
-
R
-
T
Y
K
N
L
I
I
T
R
T
F
S
K
I
Y
G
L
ASARVGYGI
A
-
D
-
K
E
I
I
N
QL-NIVRPPFN
T
T
S
I
G
Q
K
L
A
---------
I
E
A
I
K
D
--
Q
A
F
I
E
A
C-RISNANG
I
K
Q
Y
E
A
F
A
K
R
F
E
Q
----
V
----
K
L
--
Y
P-ANG
N
F
V
L
I
DL-GI-
E
A
R
T
I
F
-
S
-
Y
L
E
KNG
Y
I
TR-S-GAALG--F
P
T
A
---
V
R
I
T
IGKEEEN
S
A
V
I
A
L
L
E
K
LL-
23
HHSearch
99.65
94%
-110
- C1 -
3FFH
4
HIS8_LISIN
A:
[4-363]
-----
M
K
W
K
K
S
L
A
G
L
S
S
----
K
R
E
E
E
V
M
A
E
L
G
L
T
K
I
T
K
L
S
S
N
E
N
P
L
G
T
S
K
K
-
V
A
A
I
Q
A
N
S
S
V
----
E
T
-
E
I
Y
----
A
S
S
L
R
K
E
V
A
D
F
Y
--
Q
------
L
E
E
-
E
E
L
I
F
T
A
G
V
D
E
L
I
E
L
L
T
R
V
L
L
D
T
T
-
T
N
T
V
M
-
A
T
P
T
F
V
Q
-
Y
R
Q
N
A
L
I
E
G
A
E
V
R
E
I
P
L
L
Q
D
G
E
H
D
L
E
G
M
L
N
A
I
D
---
E
K
T
--
T
I
V
W
I
C
N
P
N
N
P
T
G
N
Y
I
E
L
A
D
I
Q
A
F
L
D
R
V
--
P
S--
D
V
L
V
V
L
D
E
A
Y
I
E
Y
V
T
-
P
Q
P
E
---
K
-
H
---
E
-
K
L
-
V
-
R
-
T
Y
K
N
L
I
I
T
R
T
F
S
K
I
Y
G
L
A
S
A
R
V
G
Y
G
I
A
-
D
-
K
E
I
I
R
Q
L
-
N
I
V
R
P
P
F
N
T
T
S
I
G
Q
K
L
A
---------
I
E
A
I
K
D
--
Q
A
F
I
G
E
C
-
R
T
S
N
A
N
G
I
K
Q
Y
E
A
F
A
K
R
F
E
K
----
V
----
K
L
--
Y
P
-
A
N
G
N
F
V
L
I
D
L
-
G
I
-
E
A
G
T
I
F
-
S
-
Y
L
E
K
N
G
Y
I
T
R
-
S
-
G
A
A
L
G
--
F
P
T
A
---
V
R
I
T
I
G
K
E
E
D
N
S
A
V
I
A
L
L
E
K
L
L
-
1
PsiBlast_PDB
99.48
93%
-110
- C1 -
3FFH
4
HIS8_LISIN
A:
[5-363]
------
K
W
K
K
S
L
A
G
L
S
S
----
K
R
E
E
E
V
M
A
E
L
G
L
T
K
I
T
K
L
S
S
N
E
N
P
L
G
T
S
K
K
-
V
A
A
I
Q
A
N
S
S
V
----
E
T
-
E
I
Y
----
A
S
S
L
R
K
E
V
A
D
F
Y
--
Q
------
L
E
E
-
E
E
L
I
F
T
A
G
V
D
E
L
I
E
L
L
T
R
V
L
L
D
T
T
-
T
N
T
V
M
-
A
T
P
T
F
V
Q
-
Y
R
Q
N
A
L
I
E
G
A
E
V
R
E
I
P
L
L
Q
D
G
E
H
D
L
E
G
M
L
N
A
I
D
---
E
K
T
--
T
I
V
W
I
C
N
P
N
N
P
T
G
N
Y
I
E
L
A
D
I
Q
A
F
L
D
R
V
P
-
S
---
D
V
L
V
V
L
D
E
A
Y
I
E
Y
V
T
-
P
Q
P
E
---
K
-
H
---
E
-
K
L
-
V
-
R
-
T
Y
K
N
L
I
I
T
R
T
F
S
K
I
Y
G
L
A
S
A
R
V
G
Y
G
I
A
-
D
-
K
E
I
I
R
Q
L
-
N
I
V
R
P
P
F
N
T
T
S
I
G
Q
K
L
A
---------
I
E
A
I
K
D
--
Q
A
F
I
G
E
C
-
R
T
S
N
A
N
G
I
K
Q
Y
E
A
F
A
K
R
F
E
K
----
V
----
K
L
--
Y
P
-
A
N
G
N
F
V
L
I
D
L
-
G
I
-
E
A
G
T
I
F
-
S
-
Y
L
E
K
N
G
Y
I
T
R
-
S
-
G
A
A
L
G
--
F
P
T
A
---
V
R
I
T
I
G
K
E
E
D
N
S
A
V
I
A
L
L
E
K
L
L
-
24
HHSearch
70.89
32%
-95
- C1 -
3GET
3
HIS8_CAMJE
A:
[2-364]
-----
M
K
F
N
E
F
L
N
N
L
S
N
Y
E
P
G
K
D
I
E
V
I
A
K
E
Y
G
V
K
E
V
I
K
L
A
S
N
E
N
P
F
G
T
P
P
K
-
A
I
E
C
L
R
Q
N
A
N
----
K
A
-
H
L
Y
P
D
D
S
M
I
E
L
K
S
T
L
A
Q
K
Y
--
K
------
V
Q
N
-
E
N
I
I
I
G
A
G
S
D
Q
V
I
E
F
A
I
H
S
K
L
N
S
K
-
N
A
F
L
Q
-
A
G
V
T
F
A
M
-
Y
E
I
Y
A
K
Q
C
G
A
K
C
Y
K
T
Q
S
I
---
T
H
N
L
D
E
F
K
K
L
Y
E
T
H
K
D
E
I
--
K
L
I
F
L
C
L
P
N
N
P
L
G
E
C
L
D
A
S
E
A
T
E
F
I
K
G
V
N
-
E
---
D
C
L
V
V
I
D
A
A
Y
N
E
F
A
S
-
F
K
D
S
KKH
L
E
P
---
C
-
E
L
-
I
-
K
-
E
F
D
N
V
L
Y
L
G
T
F
S
K
L
Y
G
L
G
G
L
R
I
G
Y
G
I
A
-
N
-
A
N
I
I
S
A
F
-
Y
K
L
R
A
P
F
N
V
S
N
L
A
L
K
A
A
---------
V
A
A
M
D
D
--
D
E
F
T
E
K
T
-
L
E
N
N
F
S
Q
M
E
L
Y
K
E
F
A
K
K
H
-
N
----
I
----
K
I
--
I
D
-
S
Y
T
N
F
I
T
Y
F
F
-
D
E
K
N
S
T
D
L
S
-
E
-
K
L
L
K
K
G
I
I
I
R
-
N
-
L
K
S
Y
G
---
L
N
A
---
I
R
I
T
I
G
T
S
Y
E
N
E
K
F
F
T
E
F
D
K
I
L
-
2
PsiBlast_PDB
68.38
32%
-87
- C1 -
3GET
3
HIS8_CAMJE
A:
[3-364]
------
K
F
N
E
F
L
N
N
L
S
N
Y
E
P
G
K
D
I
E
V
I
A
K
E
Y
G
V
K
E
V
I
K
L
A
S
N
E
N
P
F
G
T
P
P
K
A
I
E
C
L
R
Q
N
A
N
-----
K
A
-
H
L
Y
P
D
D
S
M
I
E
L
K
S
T
L
A
Q
K
Y
--
K
------
V
Q
N
-
E
N
I
I
I
G
A
G
S
D
Q
V
I
E
F
A
I
H
S
K
L
N
S
K
-
N
A
F
L
Q
-
A
G
V
T
F
A
M
-
Y
E
I
Y
A
K
Q
C
G
A
K
C
Y
K
T
Q
S
I
T
H
N
L
D
E
F
K
K
L
Y
E
T
H
K
---
D
E
I
--
K
L
I
F
L
C
L
P
N
N
P
L
G
E
C
L
D
A
S
E
A
T
E
F
I
K
G
V
N
-
E
---
D
C
L
V
V
I
D
A
A
Y
N
E
F
A
S
F
K
D
S
K
---
K
-
H
LE
P
C
-
E
L
-
I
-
K
-
E
F
D
N
V
L
Y
L
G
T
F
S
K
L
Y
G
L
G
G
L
R
I
G
Y
G
I
A
-
N
-
A
N
I
I
S
A
F
-
Y
K
L
R
A
P
F
N
V
S
N
L
A
L
K
A
A
---------
V
A
A
M
D
D
--
D
E
F
T
E
K
T
-
L
E
N
N
F
S
Q
M
E
L
Y
K
E
F
A
K
K
-
H
N
----
I
----
K
I
--
I
D
-
S
Y
T
N
F
I
T
Y
F
F
-
D
E
-
K
N
S
T
D
L
-
S
E
K
L
L
K
K
G
I
I
I
R
-
N
-
L
K
S
Y
G
--
L
-
N
A
---
I
R
I
T
I
G
T
S
Y
E
N
E
K
F
F
T
E
F
D
K
I
L
-
3
PsiBlast_PDB
65.20
29%
-84
- C1 -
4R2N
6
?
A:
[5-349]
------
R
L
R
P
E
L
A
G
L
P
V
Y
V
P
G
K
T
---------
V
P
G
A
I
K
L
A
S
N
E
T
V
F
G
P
L
P
S
-
V
R
A
A
I
D
R
A
T
D
----
T
V
-
N
R
Y
P
D
N
G
C
V
Q
L
K
A
A
L
A
R
H
L
GP
D
------
F
A
P
-
E
H
V
A
V
G
C
G
S
V
S
L
C
Q
Q
L
V
Q
V
T
A
S
V
G
-
D
E
V
V
F
-
G
W
R
S
F
E
L
-
Y
P
P
Q
V
R
V
A
G
A
I
P
I
Q
V
P
L
-
T
D
H
T
F
D
L
Y
A
M
L
A
T
V
T
---
D
R
T
--
R
L
I
F
V
C
N
P
N
N
P
T
S
T
V
V
G
P
D
A
L
A
R
F
V
E
A
V
P
-
A
---
H
I
L
I
A
I
D
E
A
Y
V
E
Y
I
R
-
D
G
M
R
---
P
-
D
---
S
L
G
L
-
V
-
R
-
A
H
N
N
V
V
V
L
R
T
F
S
K
A
Y
G
L
A
G
L
R
I
G
Y
A
I
G
-
H
-
P
D
V
I
T
A
L
-
D
K
V
Y
V
P
F
T
V
S
S
I
G
Q
A
A
A
I
A
S
L
D
A
A
D
E
L
L
A
R
T
D
--
T
V
V
A
E
R
A
-
R
V
S
A
-------
E
L
R
A
A
G
F
-----------
T
L
--
P
P
-
S
Q
A
N
F
V
W
L
P
L
-
G
S
-
R
T
Q
D
F
V
-
E
-
Q
A
A
D
A
R
I
V
V
R
-
P
-
Y
G
T
D
G
---------
V
R
V
T
V
A
A
P
E
E
N
D
A
F
L
R
F
A
R
R
---
7
PsiBlast_PDB
65.18
27%
-91
- C1 -
1GEX
2
HIS8_ECOLI
A:
[11-351]
--------
R
E
N
V
R
N
L
T
P
Y
Q
---------------
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
-
L
T
Q
Q
T
L
N
R
-----------
Y
P
E
C
Q
P
K
A
V
I
E
N
Y
A
Q
Y
A
--
G
------
V
K
P
-
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
-
K
D
A
I
L
Y
C
P
P
T
Y
G
M
-
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
--
K
V
V
Y
V
C
S
P
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
-
G
---
K
A
I
V
V
A
D
E
A
Y
I
E
F
-
C
-
P
Q
A
S
---
L
-
A
---
G
-
W
L
-
A
-
E
--
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
-
M
K
V
I
A
P
Y
P
L
S
T
P
V
A
D
I
A
---------
A
Q
A
L
S
P
--
Q
G
I
V
-
A
M
-
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
L
K
E
----
I
PCVE
Q
V
--
F
D
-
S
E
T
N
Y
I
L
A
R
F
-
K
A
-
S
S
-
A
V
F
-
K
-
S
L
W
D
Q
G
I
I
L
R
D
Q
-
N
K
Q
P
S
--
L
S
G
C
---
L
R
I
T
V
G
T
R
E
E
S
Q
R
V
I
D
A
L
-----
43
Fugue
64.05
27%
-85
- C1 -
1FG7
1
HIS8_ECOLI
A:
[3-356]
TVTIT
D
L
A
R
E
N
V
R
N
L
T
P
Y
Q
S
A
R
-------
R
L
G
G
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
-
L
T
Q
Q
T
L
N
R
-----------
Y
P
E
C
Q
P
K
A
V
I
E
N
Y
A
Q
Y
A
--
G
------
V
K
P
-
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
-
K
D
A
I
L
-
Y
C
P
P
T
Y
G
M
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
--
K
V
V
Y
V
C
S
P
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
-
G
---
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
---
P
Q
A
---
S
-
L
---
A
-
G
W
-
L
-
A
-
E
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
M
K
-
V
I
A
P
Y
P
L
S
T
P
V
A
D
I
A
---------
A
Q
A
L
S
P
--
Q
G
I
V
A
--
M
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
L
K
E
IPCV
E
----
Q
V
--
F
D
-
S
E
T
N
Y
I
L
A
R
F
-
K
--
A
S
S
A
V
F
-
K
-
S
L
W
D
Q
G
I
I
L
R
-
D
Q
N
K
Q
P
S
--
L
S
G
C
---
L
R
I
T
V
G
T
R
E
E
S
Q
R
V
I
D
A
L
R
A
E
Q
V
5
PsiBlast_PDB
63.63
27%
-85
- C1 -
1FG3
1
HIS8_ECOLI
A:
[11-351]
--------
R
E
N
V
R
N
L
T
P
Y
Q
S
A
R
R
-------
L
G
G
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
-
L
T
Q
Q
T
L
N
R
-----------
Y
P
E
C
Q
P
K
A
V
I
E
N
Y
A
Q
Y
A
--
G
------
V
K
P
-
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
-
K
D
A
I
L
Y
C
P
P
T
Y
G
M
-
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
--
K
V
V
Y
V
C
S
P
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
-
G
---
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
--
P
Q
A
S
---
L
-
A
---
G
-
W
L
-
A
-
E
--
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
-
M
K
V
I
A
P
Y
P
L
S
T
P
V
A
D
I
A
---------
A
Q
A
L
S
P
--
Q
G
I
V
-
A
M
-
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
L
K
E
----
I
PCVE
Q
V
--
F
D
-
S
E
T
N
Y
I
L
A
R
F
-
K
A
-
S
S
-
A
V
F
-
K
-
S
L
W
D
Q
G
I
I
L
R
D
Q
-
N
K
Q
P
S
--
L
S
G
C
---
L
R
I
T
V
G
T
R
E
E
S
Q
R
V
I
D
A
L
-----
6
PsiBlast_PDB
63.59
27%
-85
- C1 -
1FG7
1
HIS8_ECOLI
A:
[11-351]
--------
R
E
N
V
R
N
L
T
P
Y
Q
S
A
R
R
-------
L
G
G
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
-
L
T
Q
Q
T
L
N
R
-----------
Y
P
E
C
Q
P
K
A
V
I
E
N
Y
A
Q
Y
A
--
G
------
V
K
P
-
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
-
K
D
A
I
L
Y
C
P
P
T
Y
G
M
-
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
--
K
V
V
Y
V
C
S
P
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
-
G
---
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
--
P
Q
A
S
---
L
-
A
---
G
-
W
L
-
A
-
E
--
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
-
M
K
V
I
A
P
Y
P
L
S
T
P
V
A
D
I
A
---------
A
Q
A
L
S
P
--
Q
G
I
V
-
A
M
-
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
L
K
E
----
I
PCVE
Q
V
--
F
D
-
S
E
T
N
Y
I
L
A
R
F
-
K
A
-
S
S
-
A
V
F
-
K
-
S
L
W
D
Q
G
I
I
L
R
D
Q
-
N
K
Q
P
S
--
L
S
G
C
---
L
R
I
T
V
G
T
R
E
E
S
Q
R
V
I
D
A
L
-----
4
PsiBlast_PDB
63.43
29%
-77
- C1 -
4R5Z
12
?
A:
[5-349]
------
R
L
R
P
E
L
A
G
L
P
V
Y
V
P
G
K
T
---------
V
P
G
A
I
K
L
A
S
N
E
T
V
F
G
P
L
P
S
-
V
R
A
A
I
D
R
A
T
D
----
T
V
-
N
R
Y
P
D
N
G
C
V
Q
L
K
A
A
L
A
R
H
L
GP
D
------
F
A
P
-
E
H
V
A
V
G
C
G
S
V
S
L
C
Q
Q
L
V
Q
V
T
A
S
V
G
-
D
E
V
V
F
-
G
W
R
S
F
E
L
-
Y
P
P
Q
V
R
V
A
G
A
I
P
I
Q
V
P
L
-
T
D
H
T
F
D
L
Y
A
M
L
A
T
V
T
---
D
R
T
--
R
L
I
F
V
C
N
P
N
N
P
T
S
T
V
V
G
P
D
A
L
A
R
F
V
E
A
V
P
-
A
---
H
I
L
I
A
I
D
E
A
Y
V
E
Y
I
R
-
D
G
M
R
---
P
-
D
---
S
L
G
L
-
V
-
R
-
A
H
N
N
V
V
V
L
R
T
F
S
K
A
Y
G
L
A
G
L
R
I
G
Y
A
I
G
-
H
-
P
D
V
I
T
A
L
-
D
K
V
Y
V
P
F
T
V
S
S
I
G
Q
A
A
A
I
A
S
L
D
A
A
D
E
L
L
A
R
T
D
--
T
V
V
A
E
R
A
-
R
V
S
A
-------
E
L
R
A
A
G
F
-----------
T
L
--
P
P
-
S
Q
A
N
F
V
W
L
P
L
-
G
S
-
R
T
Q
D
F
V
-
E
-
Q
A
A
D
A
R
I
V
V
R
-
P
-
Y
G
T
D
G
---------
V
R
V
T
V
A
A
P
E
E
N
D
A
F
L
R
F
A
R
R
---
8
PsiBlast_PDB
63.40
27%
-85
- C1 -
1IJI
1
HIS8_ECOLI
A:
[11-351]
--------
R
E
N
V
R
N
L
T
P
Y
Q
S
A
R
R
-------
L
G
G
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
-
L
T
Q
Q
T
L
N
R
-----------
Y
P
E
C
Q
P
K
A
V
I
E
N
Y
A
Q
Y
A
--
G
------
V
K
P
-
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
-
K
D
A
I
L
Y
C
P
P
T
Y
G
M
-
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
--
K
V
V
Y
V
C
S
P
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
-
G
---
K
A
I
V
V
A
D
E
A
Y
I
E
F
-
C
-
P
Q
A
S
---
L
-
A
---
G
-
W
L
-
A
-
E
--
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
-
M
K
V
I
A
P
Y
P
L
S
T
P
V
A
D
I
A
---------
A
Q
A
L
S
P
--
Q
G
I
V
-
A
M
-
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
L
K
E
----
I
PCVE
Q
V
--
F
D
-
S
E
T
N
Y
I
L
A
R
F
-
K
A
-
S
S
-
A
V
F
-
K
-
S
L
W
D
Q
G
I
I
L
R
D
Q
-
N
K
Q
P
S
--
L
S
G
C
---
L
R
I
T
V
G
T
R
E
E
S
Q
R
V
I
D
A
L
-----
44
Fugue
63.33
26%
-85
- C1 -
1IJI
1
HIS8_ECOLI
A:
[3-356]
TVTIT
D
L
A
R
E
N
V
R
N
L
T
P
Y
Q
S
A
R
-------
R
L
G
G
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
-
L
T
Q
Q
T
L
N
R
-----------
Y
P
E
C
Q
P
K
A
V
I
E
N
Y
A
Q
Y
A
--
G
------
V
K
P
-
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
-
K
D
A
I
L
Y
C
P
P
T
Y
G
M
-
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
--
K
V
V
Y
V
C
S
P
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
-
G
---
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
---
P
Q
A
---
S
-
L
---
A
-
G
W
-
L
-
A
-
E
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
-
M
K
V
I
A
P
Y
P
L
S
T
P
V
A
D
I
A
---------
A
Q
A
L
S
P
--
Q
G
I
V
A
M
R
-
E
R
V
A
Q
I
-
I
A
E
R
E
Y
L
I
A
A
L
K
E
IPCV
E
----
Q
V
--
F
D
-
S
E
T
N
Y
I
L
A
R
F
-
K
--
A
S
S
A
V
F
-
K
-
S
L
W
D
Q
G
I
I
L
R
-
D
Q
N
K
Q
P
S
--
L
S
G
C
---
L
R
I
T
V
G
T
R
E
E
S
Q
R
V
I
D
A
L
R
A
E
Q
V
30
HHSearch
61.80
25%
-83
- C1 -
3LY1
10
?
A:
[14-349]
-------------------------------
S
T
D
N
P
I
R
I
N
F
N
E
N
P
L
G
M
S
P
K
-
A
Q
A
A
A
R
D
A
V
V
----
K
A
-
N
R
Y
A
K
N
E
I
L
M
L
G
N
K
L
A
A
H
H
--
Q
------
V
E
A
-
P
S
I
L
L
T
A
G
S
S
E
G
I
R
A
A
I
E
A
Y
A
S
L
E
-
A
Q
L
V
I
-
P
E
L
T
Y
G
D
-
G
E
H
F
A
K
I
A
G
M
K
V
T
K
V
K
M
L
D
N
W
A
F
D
I
E
G
L
K
A
A
V
A
A
Y-
S
G
P
--
S
I
V
Y
L
V
N
P
N
N
P
T
G
T
I
T
P
A
D
V
I
E
P
W
I
A
S
-
K
-
P
A--
N
T
M
F
I
V
D
E
A
Y
A
E
F
V
N
-
D
P
R
F
---
R
S
I
---
S
-
P
M
I
T
-
Q
-
G
A
E
N
I
I
L
L
K
T
F
S
K
I
H
A
M
A
G
M
R
V
G
Y
A
V
A
-
H
-
P
T
V
I
A
L
M
-
G
R
Y
V
A
G
E
K
I
N
F
S
G
V
D
A
A
---------
L
A
S
M
N
D
--
S
A
F
I
T
Y
S
-
K
K
S
N
D
V
S
R
Q
I
L
L
K
A
L
E
D
L
-
K
----
L
----
P
Y
--
L
P
-
S
E
G
N
F
V
F
H
Q
L
-
V
V
-
P
L
K
D
Y
Q
-
T
-
H
M
A
D
A
G
V
L
I
G
-
R
-
A
--
F
P
P-
A
D
N
W
---
C
R
I
S
L
G
T
P
Q
E
M
Q
W
V
A
D
T
M
R
E
F
R
-
27
HHSearch
61.49
25%
-83
- C1 -
3HDO
2
HIS8_GEOMG
A:
[22-352]
-----------------------------
P
P
D
I
A
S
W
I
K
L
N
T
N
E
N
P
Y
P
P
S
P
E
-
V
V
K
A
I
L
E
E
L
G
PDGA
A
L
-
R
I
Y
P
S
A
S
S
Q
K
L
R
E
V
A
G
E
L
Y
--
G
------
F
D
P
-
S
W
I
I
M
A
N
G
S
D
E
V
L
N
N
L
I
R
A
F
A
A
E
G
-
E
E
I
G
Y
-
V
H
P
S
Y
S
Y
-
Y
G
T
L
A
E
V
Q
G
A
R
V
R
T
F
G
L
T
G
D
--
F
R
I
A
G
F
P
E
R
-----
Y
E
G
--
K
V
F
F
L
T
T
P
N
A
P
L
G
P
S
F
P
L
E
Y
I
D
E
L
A
R
R
C
------
A
G
M
L
V
L
D
E
T
Y
A
E
F
A
E
-
S
N
A
----------
L
-
E
L
-
V
-
R
-
R
H
E
N
V
V
V
T
R
T
L
S
K
S
Y
S
L
A
G
M
R
I
G
L
A
I
A
-
R
-
P
E
V
I
A
A
L
-
D
K
I
R
D
H
Y
N
L
D
R
L
A
Q
A
A
C
---------
V
A
A
L
R
D
--
Q
A
Y
L
S
E
C
-
C
R
R
I
R
E
T
R
E
W
F
T
T
E
L
R
S
I
-
G
----
Y
----
D
V
--
I
P
-
S
Q
G
N
Y
L
F
A
T
P
-
P
D
R
D
G
K
R
V
Y
-
D
-
G
L
Y
A
R
K
V
L
V
R
-
H
-
F
S
D
P
L
--
L
A
H
G
---
M
R
I
S
I
G
T
R
E
E
M
E
Q
T
L
A
A
L
K
E
I
G
-
29
HHSearch
61.24
27%
-86
- C1 -
3EUC
10
HIS82_CUPPJ
A:
[26-365]
-----------------------------
V
P
D
S
H
G
L
V
K
L
D
A
M
E
N
P
Y
R
L
P
P
A
-
L
R
S
E
L
A
A
R
L
G
E
V
--
A
L
-
N
R
Y
P
V
P
S
S
E
A
L
R
A
K
L
K
E
V
M
--
Q
------
V
P
A
G
M
E
V
L
L
G
N
G
S
D
E
I
I
S
M
L
A
L
A
A
A
R
P
G
-
A
K
V
M
A
-
P
V
P
G
F
V
M
-
Y
A
M
S
A
Q
F
A
G
L
E
F
V
G
V
P
L
R
A
D
F
T
L
D
R
G
A
M
L
A
A
M
A
E
--
H
Q
P
--
A
I
V
Y
L
A
Y
P
N
N
P
T
G
N
L
F
D
A
A
D
M
E
A
I
V
R
A
A
Q
-
G
SV
C
R
S
L
V
V
V
D
E
A
Y
Q
P
F
A
Q
-
E
S
W
----------
M
-
S
R
-
L
-
T
-
D
F
G
N
L
L
V
M
R
T
V
S
K
-
L
G
L
A
G
I
R
L
G
Y
V
A
G
-
D
-
P
Q
W
L
E
Q
L
-
D
K
V
R
P
P
Y
N
V
N
V
L
T
E
A
T
A
---------
L
F
A
L
E
H
--
V
A
V
L
D
E
Q
-
A
A
Q
L
R
A
E
R
S
R
V
A
E
G
M
A
A
H
G
G
----
V
----
T
V
--
F
P
-
S
A
A
N
F
L
L
A
R
V
-
P
--
D
A
A
Q
T
F
-
D
-
R
L
L
A
R
K
V
L
I
K
-
N
-
V
S
K
M
H
PL
L
A
N
C
---
L
R
V
T
V
S
T
P
E
E
N
A
Q
F
L
E
A
F
A
A
S
L
-
10
PsiBlast_PDB
60.81
28%
-85
- C1 -
3LY1
9
?
A:
[20-337]
-------------------------------------
R
I
N
F
N
E
N
P
L
G
M
S
P
K
-
A
Q
A
A
A
R
D
A
V
V
----
K
A
-
N
R
Y
A
K
N
E
I
L
M
L
G
N
K
L
A
A
H
H
--
Q
------
V
E
A
-
P
S
I
L
L
T
A
G
S
S
E
G
I
R
A
A
I
E
A
Y
A
S
L
E
-
A
Q
L
V
I
-
P
E
L
T
Y
G
D
-
G
E
H
F
A
K
I
A
G
M
K
V
T
K
V
K
M
L
D
N
W
A
F
D
I
E
G
L
K
A
A
V
A
---
A
Y
S
G
P
S
I
V
Y
L
V
N
P
N
N
P
T
G
T
I
T
P
A
D
V
I
E
P
W
I
A
S
K
P
-
A
---
N
T
M
F
I
V
D
E
A
Y
A
E
F
V
N
D
P
R
F
R
---
S
-
I
---
S
-
P
M
-
I
T
Q
-
G
A
E
N
I
I
L
L
K
T
F
S
K
I
H
A
M
A
G
M
R
V
G
Y
A
V
A
-
H
-
P
T
V
I
A
L
M
-
G
R
Y
V
A
G
E
K
I
N
F
S
G
V
D
A
A
---------
L
A
S
M
N
D
--
S
A
F
I
T
Y
S
-
K
K
S
N
D
---
V
S
R
Q
I
L
L
K
A
L
E
D
----
L
----
K
L
P
Y
L
P
-
S
E
G
N
F
V
F
H
Q
L
-
V
V
-
P
L
K
D
Y
Q
-
T
-
H
M
A
D
A
G
V
L
I
------
G
R
A
--
F
P
P
A
DN
W
C
R
I
S
L
G
T
P
Q
E
-------------
31
HHSearch
59.96
23%
-78
- C1 -
3CQ5
6
HIS8_CORGL
A:
[28-365]
-------------------------------
Q
L
N
V
D
I
R
L
N
T
N
E
N
P
Y
P
P
S
E
A
-
L
V
A
D
L
V
A
T
V
D
K
I
AT
E
L
-
N
R
Y
P
E
R
D
A
V
E
L
R
D
E
L
A
A
Y
I
--
T
K
Q
TG
V
A
V
T
R
-
D
N
L
W
A
A
N
G
S
N
E
I
L
Q
Q
L
L
Q
A
F
G
G
P
G
-
R
T
A
L
G
-
F
Q
P
S
Y
S
M
-
H
P
I
L
A
K
G
T
H
T
E
F
I
A
V
S
R
G
A
D
F
R
I
D
M
D
V
A
L
E
E
I
R
A
--
K
Q
P
--
D
I
V
F
V
T
T
P
N
N
P
T
G
D
V
T
S
L
D
D
V
E
R
I
I
N
V
A
------
P
G
I
V
I
V
D
E
A
Y
A
E
F
S
P
-
S
P
S
A
---------
T
-
T
L
-
L
-
E
K
Y
P
T
K
L
V
V
S
R
T
M
S
K
A
F
D
F
A
G
G
R
L
G
Y
F
V
A
-
N
-
P
A
F
I
D
A
V
-
M
L
V
R
L
P
Y
H
L
S
A
L
S
Q
A
A
A
---------
I
V
A
L
R
H
--
S
A
D
T
L
G
T
-
V
E
K
L
S
V
E
R
V
R
V
A
A
R
L
E
E
L
-
G
----
Y
----
A
V
--
V
P
S
E
S
N
F
V
F
F
G
D
F
-
S
--
D
Q
H
A
A
W
-
Q
-
A
F
L
D
R
G
V
L
I
R
-
D
-
V
G
I
-----
A
G
H
---
L
R
T
T
I
G
V
P
E
E
N
D
A
F
L
D
A
A
A
E
I
I
-
28
HHSearch
59.14
24%
-86
- C1 -
3FTB
4
?
A:
[28-357]
-----------------------------------
L
L
D
Y
S
S
N
I
N
P
L
G
I
P
K
S
-
F
L
N
N
I
D
E
G
I
K
----
N
L
-
G
V
Y
P
D
V
N
Y
R
R
L
N
K
S
I
E
N
Y
L
--
K
------
L
K
D
-
I
G
I
V
L
G
N
G
A
S
E
I
I
E
L
S
I
S
L
F
-----
E
K
I
L
I
-
I
V
P
S
Y
A
E
-
Y
E
I
N
A
K
K
H
G
V
S
V
V
F
S
Y
L
D
E
N
M
C
I
D
Y
E
D
I
I
S
K
I
----
D
D
V
--
D
S
V
I
I
G
N
P
N
N
P
N
G
G
L
I
N
K
E
K
F
I
H
V
L
K
L
A
E
-
E
K
--
K
K
T
I
I
I
D
E
A
F
I
E
F
T
G
-
D
P
S
S
---
S
-
F
---
V
-
G
E
-
I
-
K
-
N
Y
S
C
L
F
I
I
R
A
M
T
K
F
F
A
M
P
G
I
R
F
G
Y
G
I
T
-
N
N
K
E
I
A
A
K
I
-
K
A
K
Q
N
P
W
N
I
N
C
F
A
E
M
A
A
---------
I
N
C
L
K
D
--
T
N
Y
I
E
E
S
-
L
L
W
I
K
K
E
R
K
R
F
I
E
E
L
N
K
I
G
F
----
I
K---
R
V
--
F
S
-
P
H
A
N
F
V
L
C
R
L
-
E
N
I
S
G
E
K
L
Y
-
D
-
S
L
L
K
E
D
I
V
I
R
-
R
-
C
C
N
F
I
GL
D
D
S
F
---
V
R
F
A
I
K
D
E
K
K
N
T
K
F
L
R
A
L
K
G
V
--
26
HHSearch
58.81
26%
-87
- C1 -
1FG7
1
HIS8_ECOLI
A:
[29-354]
---------------------------------
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
-
L
----
T
Q
--
Q
----
T
L
-
N
R
Y
P
E
C
Q
P
K
A
V
I
E
N
Y
A
Q
Y
A
--
G
------
V
K
P
-
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
K
D
A
I
L
Y
-
C
P
P
T
Y
G
M
-
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
----
D
G
V
--
K
V
V
Y
V
C
S
P
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
-
G
---
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
P
-
Q
A
S
L
---------
A
-
G
W
-
L
-
A
-
E
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
-
M
K
V
I
A
P
Y
P
L
S
T
P
V
A
D
I
A
---------
A
Q
A
L
S
P
Q
G
I
V
A
M
R
E
R
-
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
L
K
E
I
P
C
----
V
E---
Q
V
--
F
D
-
S
E
T
N
Y
I
L
A
R
F
-
K
--
A
S
S
A
V
F
-
K
-
S
L
W
D
Q
G
I
I
L
R
-
D
-
Q
N
K
Q
P
S-
L
S
G
C
---
L
R
I
T
V
G
T
R
E
E
S
Q
R
V
I
D
A
L
R
A
E
--
18
PsiBlast_PDB
57.56
26%
-85
- C1 -
3FTB
4
?
A:
[32-355]
---------------------------------------
S
S
N
I
N
P
L
G
I
-
P
K
-
S
F
L
N
N
I
D
E
G
I
----
K
N
L
G
V
Y
P
D
V
N
Y
R
R
L
N
K
S
I
E
N
Y
L
--
K
------
L
K
D
-
I
G
I
V
L
G
N
G
A
S
E
I
I
E
L
S
I
S
L
F
-----
E
K
I
L
I
-
I
V
P
S
Y
A
E
-
Y
E
I
N
A
K
K
H
G
V
S
V
V
F
S
Y
L
D
E
N
M
C
I
D
Y
E
D
I
I
S
K
I
D
---
D
V
D
--
S
V
I
-
I
G
N
P
N
N
P
N
G
G
L
I
N
K
E
K
F
I
H
V
L
K
L
A
E
E
K
---
K
K
T
I
I
I
D
E
A
F
I
E
F
T
G
-
D
P
S
S
---
S
-
F
---
V
-
G
E
-
I
-
K
-
N
Y
S
C
L
F
I
I
R
A
M
T
K
F
F
A
M
P
G
I
R
F
G
Y
G
I
T
N
N
-
K
E
I
A
A
K
I
-
K
A
K
Q
N
P
W
N
I
N
C
F
A
E
M
A
A
---------
I
N
C
L
K
D
--
T
N
Y
I
E
E
S
-
L
L
W
I
K
---
K
E
R
K
R
F
I
E
E
L
N
K
----
I
GFIK
R
V
--
F
S
-
P
H
A
N
F
V
L
C
R
L
E
N
I
-
S
G
E
K
L
Y
D
S
-
L
L
K
E
D
I
V
I
R
R
-
C
-
C
N
F
I
G
--
L
D
D
S
F
--
V
R
F
A
I
K
D
E
K
K
N
T
K
F
L
R
A
L
K
----