@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1930: (2016-03-30 )
MKLNFLYANMQKDIDSVEKELKKALSGAAADTTSAAALHLLEAGGKRIRPMFVCLSARLAANADFNAVKNASVAIELIHMASIVHDDVVDDADLRRGRETIKSKWGNHIAMYTGDFLFAKSLEYMTEIKDVAAHKMLSHVTVELSTGEIEQLKDKYNFDQSVRNYLRRIKRKTALLIAASCGLGGVVSGQSEADYQKLYRFGYYVGMAFQITDDVLDFVGTEKELGKPAGEDLRQGNVTLPVFFAMEDPFLKKRISQITEETPAEEIAVLVEEVKKTGAKQAEDVATTYLKKAVEILDSLPQVPELKPLKQIVRVLDKRNY
Atome Classification :
(26 SA)
--.........10........20........30........40-----------..--......50.........60....-----....70---.---........80.......--.90........100.......110.......----120....--..---.-----130--........140..-----.....150---.........160.......----170.......180.......-190.......200.......210.......220.......230....----...240--....------.------.--.250--.....----.-.--260------......---...270....-...-----280.-......290.......300.-.------.....310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
K
L
N
F
L
Y
A
N
M
Q
K
D
I
D
S
V
E
K
E
L
K
K
A
LSGAAADT
T
S
A
A
A
L
H
L
L
-----------
E
A--GGK
R
I
R
P
-
M
F
V
C
L
S
A
R
LAANADF-----NAVKN----
A
---
S
V
A
I
E
L
I
H
M
A
S
I
V
H
DDV--V
D
D
A
D
L
R
R
G
R
E
T
I
K
S
KWG
N
H
I
A
M
YTG
D
F
L
F
A
----
K
S
L
E
Y
M
T
--
E
I
---
K
-----
D
V
---
A
A
H
K
M
L
S
H
V
T
V
E
L-----STG
E
I
E
-----
Q
L
K
D
KYNF
D
Q
S
V
R
N
Y
L
R
R
I
----
K
RK
T
A
L
L
I
A
ASCGLGGVVSG-QS
E
A
D
Y
Q
K
L
Y
R
F
G
Y
Y
V
G
M
A
F
Q
I
T
D
D
V
L
D
F
VG
T
E
K
E
LGKPA
G
E
D
LRQG----N
V
T
L
P
V
--
F
F
AM------E------
D
--
P
F
L
K
--
K
R
I
S
Q
----
I
-
T
--E--------ET
P
A
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---
I
A
V
L
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E
E
V
K
K
-TGA-----
K
Q
A
E
-
D
V
A
T
T
Y
L
K
K
A
V
E
I
L
D
SLPQV-P------E
L
K
P
L
K
Q
I
V
R
V
L
DKRNY
55
Fugue
94.25
36%
-88
* C1 *
3AQB
3
HEXB_MICLU
B:
[5-325]
------
S
Y
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
D
S
-
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
G
K
R
V
R
P
-
M
F
V
L
L
S
G
F
L
N
D
T
Q
K
------
D
D
L
I
R
----
T
---
A
V
S
L
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M
A
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Y
--
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A
----
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A
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N
I
A
--
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---
N
-----
N
S
---
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F
H
Q
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T
I
L
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V
-----
C
F
G
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F
D
-----
Q
M
A
D
R
F
N
Y
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F
T
A
Y
L
R
R
I
----
N
R
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A
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L
I
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A
S
C
H
L
G
A
L
S
S
Q
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L
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S
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Y
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Q
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M
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Y
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D
D
I
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T
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D
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R
N
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----
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I
T
Y
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--
M
A
A
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------
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N
L
K
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D
--
D
K
L
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--
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V
V
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----
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--
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--------
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D
D
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---
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Q
Y
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K
Q
-
Y
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I
-----
E
P
A
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-
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
-
N
------
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
22
PsiBlast_CBE
89.49
36%
-90
- C1 -
3AQB
3
HEXB_MICLU
D:
[17-325]
------------------
V
E
K
R
L
Y
E
C
I
Q
-
S
D
S
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
G
K
R
V
R
P
-
M
F
V
L
L
S
G
F
L
N
D
T
Q
K
D
-----
D
L
I
R
T
----
A
----
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S
L
E
L
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A
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V
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D
D
Y
--
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A
----
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A
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N
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A
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---
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-----
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---
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F
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A
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Y
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A
Y
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----
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R
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H
L
G
A
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Q
-
L
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Y
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D
I
L
D
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D
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A
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K
P
V
G
S
D
I
R
N
G
----
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I
T
Y
P
L
--
M
A
A
I
ANLKEQ
D
------
D
--
D
K
L
E
--
A
V
V
K
H
----
L
-
T
--
S
--------
T
S
D
D
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V
---
Y
Q
Y
I
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S
Q
V
K
Q
-
Y
G
I
-----
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P
A
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-
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
-
N
------
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
70
HHSearch
89.18
36%
-86
- C1 -
3AQB
3
HEXB_MICLU
B:
[7-325]
--------
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
G
K
R
V
R
P
-
M
F
V
L
L
S
G
F
L
N
D
T
-
Q
K
-----
D
D
L
I
R
----
T
---
A
V
S
L
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L
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H
M
A
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L
V
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D
D
Y
--
I
D
N
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D
T
A
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G
H
F
L
L
A
----
R
A
L
Q
N
I
A
--
T
I
---
N
-----
N
S
---
K
F
H
Q
I
F
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K
T
I
L
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-----
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F
G
E
F
D
-----
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M
A
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Y
P
V
S
F
T
A
Y
L
R
R
I
----
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
----
H
I
T
Y
P
L
--
M
A
A
I
------
A
------
N
--
L
K
E
Q
DD
D
K
L
E
A
----
V
V
K
--
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LTS-----
T
S
D
D
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---
Y
Q
Y
I
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V
K
Q
Y
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-----
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P
A
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L
L
S
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Y
G
D
K
A
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L
S
Q
L
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D
S
-
N
------
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
1
PsiBlast_PDB
88.97
36%
-87
- C1 -
3AQB
3
HEXB_MICLU
B:
[17-325]
------------------
V
E
K
R
L
Y
E
C
I
Q
-
S
D
S
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
G
K
R
V
R
P
-
M
F
V
L
L
S
G
F
L
N
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T
Q
K
D
-----
D
L
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R
T
----
A
----
V
S
L
E
L
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M
A
S
L
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D
Y
--
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M
R
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T
S
V
H
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D
K
D
T
A
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R
T
G
H
F
L
L
A
----
R
A
L
Q
N
I
A
--
T
I
---
N
-----
N
S
---
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F
H
Q
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K
T
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L
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-----
C
F
G
E
F
D
-----
Q
M
A
D
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N
Y
P
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T
A
Y
L
R
R
I
----
N
R
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L
I
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A
S
C
H
L
G
A
L
S
S
Q
-
L
D
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S
T
Y
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Q
F
G
H
C
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G
M
S
Y
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D
I
L
D
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T
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D
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A
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K
P
V
G
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I
R
N
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----
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I
T
Y
P
L
--
M
A
A
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A
N
L
K
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Q
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------
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--
D
K
L
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A
V
V
K
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----
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-
T
--
S
--------
T
S
D
D
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---
Y
Q
Y
I
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K
Q
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Y
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-----
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P
A
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L
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L
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-
N
------
I
K
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Y
L
E
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I
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K
M
L
K
R
V
Y
21
PsiBlast_CBE
88.61
36%
-90
- C1 -
3AQC
5
HEXB_MICLU
D:
[17-325]
------------------
V
E
K
R
L
Y
E
C
I
Q
-
S
D
S
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
G
K
R
V
R
P
-
M
F
V
L
L
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G
F
L
N
D
T
Q
K
D
-----
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L
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T
----
A
----
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A
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--
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K
D
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H
F
L
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A
----
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A
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N
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A
--
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-----
N
S
---
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M
A
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Y
P
V
S
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A
Y
L
R
R
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----
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
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Q
F
G
H
C
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M
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Y
Q
I
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D
I
L
D
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D
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A
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P
V
G
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R
N
G
----
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T
Y
P
L
--
M
A
A
I
ANLKEQ
D
------
D
--
D
K
L
E
--
A
V
V
K
H
----
L
-
T
--
S
--------
T
S
D
D
E
V
---
Y
Q
Y
I
V
S
Q
V
K
Q
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Y
G
I
-----
E
P
A
E
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L
L
S
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Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
-
N
------
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
2
PsiBlast_PDB
86.39
36%
-85
- C1 -
3AQC
5
HEXB_MICLU
B:
[17-325]
------------------
V
E
K
R
L
Y
E
C
I
Q
-
S
D
S
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
G
K
R
V
R
P
-
M
F
V
L
L
S
G
F
L
N
D
T
Q
K
D
-----
D
L
I
R
T
----
A
----
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
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D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
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R
T
G
H
F
L
L
A
----
R
A
L
Q
N
I
A
--
T
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---
N
-----
N
S
---
K
F
H
Q
I
F
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K
T
I
L
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-----
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F
G
E
F
D
-----
Q
M
A
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F
N
Y
P
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F
T
A
Y
L
R
R
I
----
N
R
K
T
A
I
L
I
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A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
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G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
----
H
I
T
Y
P
L
--
M
A
A
I
A
N
L
K
E
Q
D
------
D
--
D
K
L
E
--
A
V
V
K
H
----
L
-
T
--
S
--------
T
S
D
D
E
V
---
Y
Q
Y
I
V
S
Q
V
K
Q
-
Y
G
I
-----
E
P
A
E
-
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
-
N
------
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
73
HHSearch
80.58
31%
-83
- C1 -
1WY0
2
?
A:
[4-341]
----
Y
E
E
L
F
A
R
I
K
E
K
A
K
L
I
D
E
K
I
F
E
L
I
P
E
K
D
P
R
V
L
Y
E
A
A
R
H
Y
P
-----------
L
A
--
G
G
K
R
V
R
P
-
F
V
V
L
T
S
T
E
A
V
G
G
-
D
P
-----
L
R
A
I
Y
----
P
---
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
--
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
----
K
A
F
E
A
V
A
--
R
A
---
E
IP
P
E
K
K
A
---
R
V
L
E
V
I
V
K
A
S
N
E
L
-----
C
E
G
Q
A
R
-----
D
L
E
F
E
K
K
S
T
V
T
I
E
E
Y
M
E
M
I
----
S
G
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
-
D
N
E
E
Y
I
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
----
K
K
T
L
I
V
--
A
H
F
F
------
E
------
N
--
A
D
E
K
D
K
Q
R
F
L
K
----
I
F
G
--
K
---------
D
I
K
S
D
---
V
M
E
A
I
D
L
L
K
K
Y
G
S
I
-----
D
Y
A
A
-
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
-
K
------
A
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
63
Fugue
77.99
31%
-102
- C1 -
3OYR
1
?
A:
[20-343]
KS
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
D
V
A
-
I
I
P
A
L
A
E
H
L
I
-----------
A
A
--
G
G
K
R
L
R
P
-
L
M
T
V
A
A
A
R
L
A
-
G
A
D
N
-----
D
H
F
Q
K
----
L
---
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
V
A
A
H
L
---------
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
----
R
A
F
E
L
M
V
--
E
T
---
N
-----
S
M
---
K
A
L
E
I
L
A
R
A
S
R
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
R
S
H
D
L
N
L
S
Q
A
V
Y
L
E
I
I
----
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
-
V
D
V
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
A
-----------------------
T
L
P
L
--
L
L
A
I
------
A
------
R
--
S
G
P
R
--
E
A
E
F
W
----
E
-
R
--
A
--------
I
G
T
E
A
D
---
F
R
R
A
R
E
L
I
I
G
-
S
G
A
L
----
D
A
T
L
-
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
-
D
------
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
9
PsiBlast_PDB
75.43
34%
-86
- C1 -
1WY0
2
?
A:
[37-341]
-------------------------------------
A
A
R
H
Y
P
-----------
L
A
--
G
G
K
R
V
R
P
--
F
V
V
L
T
S
T
E
A
V
G
G
D
P
-----
L
R
A
I
Y
----
P
---
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
--
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
----
K
A
F
E
A
V
A
R
A
E
I
P
P
E
K
-----
K
A
---
R
V
L
E
V
I
V
K
A
S
N
E
L
-----
C
E
G
Q
A
R
-----
D
L
E
F
E
K
K
S
T
V
T
I
E
E
Y
M
E
M
I
----
S
G
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
-
D
N
E
E
Y
I
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
----
K
K
T
L
I
V
A
H
F
F
E
N
------
A
------
D
--
E
K
D
K
--
Q
R
F
L
K
I
FGK---------------
D
I
K
S
D
---
V
M
E
A
I
D
L
L
K
K
-
Y
G
S
I
----
D
Y
A
A
-
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
-
K
------
A
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
67
HHSearch
74.15
32%
-95
- C1 -
3OYR
1
?
A:
[27-343]
-------
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
-----------
A
A
--
G
G
K
R
L
R
P
-
L
M
T
V
A
A
A
R
L
A
G
A
-
D
N
-----
D
H
F
Q
K
----
L
---
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
----
R
A
F
E
L
M
V
--
E
T
---
N
-----
S
M
---
K
A
L
E
I
L
A
R
A
S
R
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
R
S
H
D
L
N
L
S
Q
A
V
Y
L
E
I
I
----
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
-
V
D
V
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-----------------------
A
T
L
P
L
--
L
L
A
I
------
A
------
R
--
S
G
P
R
EA
E
F
W
E
R
----
A
I
G
-------------
T
E
A
D
---
F
R
R
A
R
E
L
I
I
G
S
G
A
L
-----
D
A
T
L
-
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
-
D
------
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
7
PsiBlast_PDB
73.72
32%
-84
- C1 -
3LMD
-
?
A:
[34-348]
-------
L
T
A
R
I
N
D
A
M
V
Q
V
E
E
L
L
H
T
E
L
S
-
S
G
E
D
F
L
V
D
I
V
M
H
L
T
-----------
R
A
--
G
G
K
R
F
R
P
-
M
F
A
L
L
A
S
E
F
G
E
K
P
L
S
-----
E
N
V
I
K
----
A
---
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
-----------
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
----
H
A
S
G
L
M
S
--
Q
L
G--
T
-----
D
T
---
V
A
H
--
F
A
E
T
F
G
E
L
-----
V
T
G
Q
M
R
-----
E
T
V
G
P
R
D
T
D
-
P
I
E
H
Y
T
N
V
I
----
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
P
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
--------
P
G
T
D
L
R
E
G
----
V
F
T
L
P
V
--
L
Y
A
L
R
-----
E
------
D
--
T
P
V
G
--
A
E
L
R
D
----
I
-
L
-----------
T
G
P
L
E
D
D
E
T
V
N
H
V
L
E
L
L
S
Q
-
S
G
G
-----
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
-
T
------
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
8
PsiBlast_PDB
73.49
32%
-87
- C1 -
3Q2Q
5
?
A:
[36-350]
-------
L
T
A
R
I
N
D
A
M
V
Q
V
E
E
L
L
H
T
E
L
S
-
S
G
E
D
F
L
V
D
I
V
M
H
L
T
-----------
R
A
--
G
G
K
R
F
R
P
-
M
F
A
L
L
A
S
E
F
G
E
K
P
L
S
-----
E
N
V
I
K
----
A
---
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
E
A
-------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
----
H
A
S
G
L
M
S
--
Q
L
G--
T
-----
D
T
---
V
A
H
--
F
A
E
T
F
G
E
L
-----
V
T
G
Q
M
R
-----
E
T
V
G
P
R
D
T
D
-
P
I
E
H
Y
T
N
V
I
----
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
P
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
----
V
F
T
L
P
V
--
L
Y
A
L
R
-----
E
------
D
--
T
P
V
G
--
A
E
L
R
D
----
I
-
L
-----------
T
G
P
L
E
D
D
E
T
V
N
H
V
L
E
L
L
S
Q
-
S
G
G
-----
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
-
T
------
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
74
HHSearch
71.08
28%
-81
- C1 -
3NF2
6
?
A:
[5-341]
-------
V
T
A
L
L
E
R
G
R
T
L
A
T
P
V
L
R
A
A
V
D
R
-
L
A
P
P
M
D
T
V
A
A
Y
H
F
GWIDAQGNPAD
G
D
--
G
G
K
A
V
R
P
-
A
L
A
V
L
S
A
E
V
T
G
A
-
A
P
-----
E
V
G
V
P
----
G
---
A
V
A
V
E
L
V
H
N
F
S
L
L
H
D
D
L
--
M
D
G
D
E
Q
R
R
H
R
D
T
V
W
K
V
H
G
P
A
Q
A
I
L
V
G
D
A
L
F
A
----
L
A
N
E
V
L
L
--
E
L
---
G
-----
T
V
E
A
G
R
A
T
R
R
L
T
K
A
S
R
S
L
-----
I
D
G
Q
A
Q
-----
D
I
S
Y
E
H
R
D
R
V
S
V
E
E
C
L
E
M
E
----
G
N
K
T
G
A
L
L
A
C
A
S
S
I
G
A
V
L
G
G
-
A
D
E
R
T
A
D
T
L
E
K
Y
G
Y
H
L
G
L
A
F
Q
A
V
D
D
L
L
G
I
W
G
D
P
D
A
T
G
K
Q
T
W
S
D
L
R
Q
R
----
K
K
S
L
P
V
--
V
A
A
L
------
A
------
A
--
G
G
A
A
S
-
E
R
L
G
E
----
I
L
T
--
A
D
A
K
ASDFA
N
F
S
E
E
E
---
F
A
A
R
A
A
L
I
E
E
A
G
G
R
-----
E
W
T
A
-
D
E
A
R
R
Q
H
T
I
A
I
E
A
L
D
A
V
D
M
P
D
R
------
V
R
D
R
F
T
A
L
A
D
F
V
V
V
---
71
HHSearch
69.14
31%
-80
- C1 -
3LMD
-
?
A:
[33-348]
------
E
L
T
A
R
I
N
D
A
M
V
Q
V
E
E
L
L
H
T
E
L
S
S
-
G
E
D
F
L
V
D
I
V
M
H
L
T
-----------
R
A
--
G
G
K
R
F
R
P
-
M
F
A
L
L
A
S
E
F
G
E
K
P
L
S
-----
E
N
V
I
K
----
A
---
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
-----------
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
----
H
A
S
G
L
M
S
--
Q
L
---
G
------
T
---
D
T
V
A
H
F
A
E
T
F
G
E
L
-----
V
T
G
Q
M
R
-----
E
T
V
G
P
R
D
-
T
D
P
I
E
H
Y
T
N
V
I
----
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
P
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
--------
P
G
T
D
L
R
E
G
----
V
F
T
L
P
V
--
L
Y
A
L
------
R
------
E
--
D
T
P
V
G
-
A
E
L
R
D
----
I
L
T
G-
P
--------
L
E
D
D
E
T
---
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
-----
Q
A
A
L
-
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
-
T
------
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
69
HHSearch
68.79
27%
-88
- C1 -
3APZ
-
SPS3_ARATH
A:
[8-348]
-----
L
D
P
F
S
L
V
A
D
E
L
S
L
L
S
N
K
L
R
E
M
V
L
A
-
E
V
P
-----------------------GV
Q
G
K
Q
F
R
S
-
T
I
L
L
L
M
A
T
A
L
D
V
---T
S
E
L
R
V
R
Q
R
G
----
I
---
A
E
I
T
E
M
I
H
V
A
S
L
L
H
D
D
------------------
V
M
G
N
K
M
S
V
L
A
G
D
F
L
L
S
----
R
A
C
G
A
L
A
--
A
L
---
K
-----
N
T
---
E
V
V
A
L
L
A
T
A
V
E
H
L
-----
V
T
G
E
T
M
-----
E
I
T
S
S
T
E
Q
R
Y
S
M
D
Y
Y
M
Q
K
T
----
Y
Y
K
T
A
S
L
I
S
N
S
C
K
A
V
A
V
L
T
G
-
Q
T
A
E
V
A
V
L
A
F
E
Y
G
R
N
L
G
L
A
F
Q
L
I
D
D
I
L
D
F
T
G
T
S
A
S
L
G
K
G
S
L
S
D
I
R
H
G
----
V
I
T
A
P
I
--
L
F
A
M
------
E
------
E
--
F
P
Q
-----
L
R
E
----
V
V
D
Q
-
V
--------
E
K
D
P
R
N
---
V
D
I
A
L
E
Y
L
G
K
S
K
G
I
-----
Q
R
A
R
-
E
L
A
M
E
H
A
N
L
A
A
A
A
I
G
S
L
P
E
T
-
D
N
E
D
V
K
R
S
R
R
A
L
I
D
L
T
H
R
V
I
T
R
N
K
82
HHSearch
67.24
26%
-91
- C1 -
3IPI
6
GFPS_METMA
A:
[8-283]
------------
W
E
E
Y
R
Y
V
E
A
G
I
K
E
S
I
T
L
I
E
D
P
G
L
K
K
M
V
E
H
V
C
-----------
H
S
--
G
G
K
R
I
R
P
-
I
I
L
L
L
V
S
E
I
C
S
G
-
S
Y
-----
S
R
S
L
N
----
A
---
A
L
A
V
E
M
M
H
S
A
S
L
I
H
D
D
L
--
L
D
Q
G
L
V
R
R
N
L
P
S
A
P
E
K
F
G
P
S
G
A
L
L
C
G
D
Y
L
I
A
----
K
S
I
A
F
I
S
--
P
Y
---
G
------
E
---
K
V
I
Q
D
F
G
K
A
G
M
D
M
-----
A
E
G
E
V
L
-----
D
L
K
--------
E
N
D
Y
F
K
C
I
----
Y
K
K
T
A
S
L
F
A
I
S
A
S
I
G
A
Y
T
G
G
-
A
E
E
E
L
A
E
R
F
S
H
F
G
N
A
L
G
T
A
Y
Q
I
V
D
D
I
L
E
F
L
E
V
V
--
E
G
---------------
E
T
L
P
H
--
I
Y
M
K
------
S
------
T
--
S
K
E
E
----------------------------------------------
A
L
-----
K
K
S
I
-
D
C
V
K
L
H
V
A
A
A
K
E
T
L
E
T
F
R
E
C
-
P
------
A
R
D
K
L
F
Q
I
T
D
Y
I
T
V
D
M
-
31
PsiBlast_CBE
66.88
32%
-92
- C1 -
3WJN
1
?
B:
[52-335]
----------------------------------------
Y
I
V
-----------
S
G
--
G
G
K
R
I
R
P
-
M
I
A
V
L
A
A
R
-
A
V
G
Y
E
G
-----
N
A
H
V
T
----
I
---
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
----
R
A
F
Q
M
M
T
--
S
L
---
G
-----
S
L
---
K
V
L
E
V
M
S
E
A
V
N
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
N
V
N
D
P
D
I
T
E
E
N
Y
M
R
V
I
----
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
-
C
T
P
E
E
E
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
-------
K
N
V
G
D
D
L
N
E
G
----
K
P
T
L
P
L
--
L
H
A
M
------
H
------
H
GT
P
E
Q
A
--
Q
M
I
R
T
----
A
-
I
--
E
--------
Q
G
N
G
R
H
L--
L
E
P
V
L
E
A
M
N
A
-
C
G
S
L
E
W
T
R
Q
R
A
E
-
E
E
A
----
D
K
A
I
A
A
L
Q
V
L
P
D
T
-
P
------
W
R
E
A
L
I
G
L
A
H
I
A
V
Q
R
--
72
HHSearch
66.29
27%
-83
- C1 -
3PKO
2
?
A:
[16-333]
------
R
Q
F
P
Q
V
E
P
Q
L
T
A
L
Q
D
Y
L
L
R
T
V
Q
-
L
D
N
Q
P
I
H
H
K
I
L
A
L
L
-----------
K
S
--
G
G
K
L
L
R
P
-
G
Y
F
Y
L
F
S
T
F
G
N
A
A
T
P
-----
A
Q
L
Q
A
----
G
---
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
----
V
Y
F
D
Q
V
L
--
K
S
---
T
T----
D
R
---
S
L
I
Q
N
H
I
D
A
M
H
R
I
-----
L
Q
G
E
L
H
-----
Q
M
D
L
N
Y
R
E
D
I
T
L
D
A
Y
L
N
E
I
----
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
-
A
P
Q
S
V
I
D
R
T
R
D
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
----
V
Y
S
L
P
L
--
L
L
S
L
------
S
------
H
--
A
P
R
D
----
F
H
K
----
L
L
K
KK
Q
--------
A
M
T
L
E
D
---
I
K
H
V
Q
A
L
V
A
Q
Y
D
G
V
-----
G
A
A
K
-
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
-
S
------
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
6
PsiBlast_PDB
66.26
32%
-89
- C1 -
3WJO
2
?
A:
[52-333]
----------------------------------------
Y
I
V
-----------
S
G
--
G
G
K
R
I
R
P
-
M
I
A
V
L
A
A
R
-
A
V
G
Y
E
G
-----
N
A
H
V
T
----
I
---
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
----
R
A
F
Q
M
M
T
--
S
L
---
G
-----
S
L
---
K
V
L
E
V
M
S
E
A
V
N
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
N
---------
N
Y
M
R
V
I
----
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
-
C
T
P
E
E
E
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
----
K
P
T
L
P
L
--
L
H
A
M
------
H
------
H
GT
P
E
Q
A
--
Q
M
I
R
T
----
A
-
I
--
E
--------
Q
G
N
G
R
H
L--
L
E
P
V
L
E
A
M
N
A
-
C
G
S
L
E
W
T
R
Q
R
A
E
-
E
E
A
----
D
K
A
I
A
A
L
Q
V
L
P
D
T
-
P
------
W
R
E
A
L
I
G
L
A
H
I
A
V
----
5
PsiBlast_PDB
64.68
33%
-85
- C1 -
4LOB
4
?
A:
[63-341]
----------------------------------------
H
V
V
-----------
E
A
--
G
G
K
R
M
R
P
-
I
M
C
L
L
A
A
R
---
A
C
D
L
-----
D
N
M
Q
N
----
A
Q
R
L
A
A
I
I
E
M
L
H
T
A
T
L
V
H
D
D
V
--
V
D
--------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
----
R
A
F
D
L
L
V
--
D
L
---
N
-----
N
M
---
T
L
L
K
D
F
S
T
G
T
C
E
I
-----
A
E
G
E
V
L
-----
Q
L
Q
S
Q
H
Q
P
D
T
T
E
E
T
Y
L
K
I
I
----
H
G
K
T
S
R
L
F
E
L
A
T
E
G
A
A
I
L
A
G
-
Q
-
E
A
Y
R
E
P
L
R
L
F
A
G
H
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
----
K
P
T
L
P
L
--
I
S
A
L
A
H
S
TG
E
E
------
H
--
A
I
I
R
--
R
S
I
A
T
-------------------
G
G
V
D
Q
---
L
P
K
V
I
E
I
V
Q
K
-
S
G
A
L
----
D
Y
C
Q
-
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
I
L
P
D
T
-
P
------
Y
R
Q
A
L
I
N
L
T
R
L
------
11
PsiBlast_PDB
49.26
31%
-69
- C1 -
3PKO
2
?
A:
[48-333]
---------------------------------------
L
A
L
L
-----------
K
S
--
G
G
K
L
L
R
P
-
G
Y
F
Y
L
F
S
T
F
G
N
A
A
T
P
-----
A
Q
L
Q
A
----
G
---
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
K
S
T
T
--
D
R
---
S
-----
L
I
---
Q
N
H
I
D
A
M
H
R
I
L
Q
--------
G
E
L
H
-----
Q
M
D
L
N
Y
R
E
D
I
T
L
D
A
Y
L
N
E
I
----
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
-
A
P
Q
S
V
I
D
R
T
R
D
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
VYS
L
P
L
L
L
S
L
--
S
H
A
P
------
R
------
D
F
H
K
L
L
K
--
K
K
Q
A
M
----
T
-
L
--
E
--------
D
I
--
K
H
---
V
Q
A
L
V
A
Q
Y
D
G
-
V
G
A
-------
A
K
-
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
-
S
------
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
23
PsiBlast_CBE
47.08
38%
-69
- C1 -
3OYR
4
?
B:
[55-289]
------------------------------------
A
L
A
E
H
L
I
-----------
A
A
--
G
G
K
R
L
R
P
-
L
M
T
V
A
A
A
R
L
A
-
G
A
D
N
-----
D
H
F
Q
K
----
L
---
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
----
R
A
F
E
L
M
V
--
E
T
---
N
-----
S
M
---
K
A
L
E
I
L
A
R
A
S
R
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
R
S
H
D
L
N
L
S
Q
A
V
Y
L
E
I
I
----
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
-
V
D
V
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
----
K
A
T
L
P
L
--
L
L
A
I
A
R
SGPR
E
------
A
--
E
F
W
E
--
R
A
I
G
R
------
R
--
E
--------
Q
T
E
A
D
-------------------------------------------------------------------------
52
PsiBlast_CBE
27.79
32%
-63
- C1 -
3Q1O
5
?
C:
[54-256]
----------------------------------------------------------
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
-----
S
N
Q
Q
T
EYFK
I
---
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
----
Y
S
F
E
L
L
S
--
N
A
---
L
--------------
L
E
S
H
I
I
V
E
L
IKILS
A
N
G
G
I
K
GMILG
Q
A
L
D
C
Y
-
F
E
N
T
P
L
N
-
L
E
Q
L
TFLH
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
27.27
32%
-65
- C1 -
3Q1O
3
?
D:
[54-256]
----------------------------------------------------------
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
-----
S
N
Q
Q
T
EYFK
I
---
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
----
Y
S
F
E
L
L
S
--
N
A
---
L
--------------
L
E
S
H
I
I
V
E
L
IKILS
A
N
G
G
I
K
GMILG
Q
A
L
D
C
Y
-
F
E
N
T
P
L
N
-
L
E
Q
L
TFLH
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
26.85
32%
-63
- C1 -
3Q1O
3
?
B:
[54-256]
----------------------------------------------------------
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
-----
S
N
Q
Q
T
E
Y
F
K
I
---
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
----
Y
S
F
E
L
L
S
--
N
A
---
L
--------------
L
E
S
H
I
I
V
E
L
I
K
I
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
-
F
E
N
T
P
L
N
-
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
25.44
32%
-62
- C1 -
3Q1O
4
?
A:
[54-256]
----------------------------------------------------------
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
-----
S
N
Q
Q
T
E
Y
F
K
I
---
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
----
Y
S
F
E
L
L
S
--
N
A
---
L
--------------
L
E
S
H
I
I
V
E
L
I
K
I
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
-
F
E
N
T
P
L
N
-
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------