@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1936: (2016-03-30 )
MTQKKVAILGAGSWGTGLALVLADNNHKPVIWGNLDKIVNEINESHTNSHYLPDIILPTEVKATLSLDEAIDGAEIVVIAIPTNAMRIVCKQLNEALKEPTILVHVSKGIEPETNLRMSEVIEEEIDAAKRKALVVLSGPSHAEEVALRHPTTLCASCKDLSAAEIVQDRFINNNLRIYTNDDVIGAEIGGALKNIIALGAGISDGLGYGDNAKAALMTRGMAEITRLGVAVGSNPQTFYGLTGIGDLIVTCTSVHSRNWRAGNMLGKGENLDEVLEKMGMVVEGVRTAKAVHGWAKKLDIDMPITESIYAILFENKDAREAVDLLMGREKKIEKESF
Atome Classification :
(20 SA)
----.........10........20-------..-------...------...30--..------------...-----..-----.40........50........60........70........80........90.----.-----...----.-..100....-...110-..--..-...-.120.......130.......140.......150--------.........160.......170--.--......180-.........190.......200.......210.......220...---....230.--..---.---...240.-......250.......260.....-.-.270....----...---280....--...290..--....---.300-........310.......320.-......330......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MT
Q
K
K
V
A
I
L
GAGSWGT
G
L
A
L
V
-------
L
A-------DNN------HK
P
V
I
--WG------------
N
L
D
-----
K
I
-----
V
N
E
I
N
ESHTNSHYLPDIILPTE
V
K
A
T
L
SLDEAIDG
A
E
I
V
V
I
A
IPT
N
A
M
R
I
V
C
K
Q
----
L
-----
N
E
A
----L-KE
P
T
I
L
V
H
V-SKGIE--PE--TN-L
R
M
-
S
E
V
I
E
E
E
I
D
A
A
K
R
K
A
L
V
V
LSGPS
H
A
E
E
V
A
LRH----------
P
T
T
L
C
A
SCKDL
S
A
A
E
I
V
Q
D
R
FI--N--NN
L
R
I
Y
T---NDDVI
G
A
E
I
G
G
A
L
K
N
I
I
A
LGAGISDGLGYGDN
A
K
A
A
L
M
T
R
G
M
A
E
I
---
T
R
L
G
V
AVG--SN---P---
Q
T
F
Y
GLT-GIG
D
L
I
V
T
C
TSVHSRNWRAGNMLG-K-GE
N
L
D
E
V
L
----
E
K
M
---
G
M
V
V
E
G
V
--
R
T
A
K
A
V
H
G
--
W
A
K
K---LDI--DMP
I
T
E
S
I
Y
A
I
LFENK
D
A
R
E
A
V
-
D
L
L
MGREKKIEKESF---
2
PsiBlast_PDB
96.10
37%
-108
- C1 -
3K96
1
GPDA_COXBU
A:
[32-352]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
-------
L
A
-------
R
K
G
------
Q
K
V
R
L
--
W
S
------------
Y
E
S
-----
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
-----
K
P
L
----
I
-
D
A
K
T
R
I
A
W
G
-
T
K
G
L
A
--
K
G
--
S
R
-
L
-
L
-
H
E
V
V
A
T
E
L
G
---
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
----------
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
---
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
G
--
G
K
---
Q
---
E
T
L
T
G
L
A
-
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
----
Q
A
I
---
G
Q
A
I
E
G
L
--
Y
N
T
D
Q
V
H
A
--
L
A
Q
K
---
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
-
Q
E
L
L
E
R
S
-----------
27
HHSearch
96.04
37%
-103
- C1 -
3K96
1
GPDA_COXBU
A:
[27-352]
----
P
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
-------
L
A
-------
R
K
G
------
Q
K
V
R
L
--
W
S
------------
Y
E
S
-----
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
-----
K
P
L
----
I
-
D
A
K
T
R
I
A
W
G
-
T
K
G
L
A
--
K
G
--
S
--
R
L
L
-
H
E
V
V
A
T
E
L
---
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
----------
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
---
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
G
--
G
K
---
Q
---
E
T
L
T
G
L
A
-
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
----
Q
A
I
---
G
Q
A
I
E
G
L
--
Y
N
T
D
Q
V
H
A
--
L
A
Q
K
---
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
-
Q
E
L
L
E
R
S
-----------
21
PsiBlast_CBE
95.17
37%
-107
- C1 -
3K96
2
GPDA_COXBU
B:
[32-351]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
-------
L
A
-------
R
K
G
------
Q
K
V
R
L
--
W
S
------------
Y
E
S
-----
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
-----
K
P
L
----
I
-
D
A
K
T
R
I
A
W
G
-
T
K
G
L
A
--
K
G
--
S
R
-
L
-
L
-
H
E
V
V
A
T
E
L
G
---
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
----------
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
---
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
G
--
G
K
---
Q
---
E
T
L
T
G
L
A
-
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
----
Q
A
I
---
G
Q
A
I
E
G
L
--
Y
N
T
D
Q
V
H
A
--
L
A
Q
K
---
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
-
Q
E
L
L
E
R
------------
28
HHSearch
93.14
45%
-99
- C1 -
1Z82
7
?
A:
[14-325]
------
E
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
-------
L
H
-------
E
N
G
------
E
E
V
I
L
--
W
A
------------
R
R
K
-----
E
I
-----
V
D
L
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
K
--
I
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
----
L
-----
P
V
--------
K
P
S
M
V
L
N
L
-
S
K
G
I
E
--
I
K
--
T
G
-
K
R
V
-
S
E
I
V
E
E
I
L
---
G
-
C
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
----------
P
T
A
V
T
L
A
G
E
N
S
---
K
E
L
Q
K
R
I
S
--
T
--
E
Y
F
R
V
Y
T
---
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
G
--
A
D
---
Q
---
K
T
F
M
G
L
A
-
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
-
R
G
F
N
-
P
L
K
L
L
E
S
--
S
-----
N
Q
V
V
E
G
A
--
F
T
V
K
A
V
M
K
--
I
A
K
E
---
N
K
I
--
D
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
-
R
D
L
M
R
-------------
1
PsiBlast_PDB
91.81
42%
-98
- C1 -
1Z82
7
?
A:
[14-325]
------
E
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
-------
L
H
-------
E
N
G
------
E
E
V
I
L
--
W
A
------------
R
R
K
-----
E
I
-----
V
D
L
I
N
V
S
H
T
S
P
Y
V
E
E
S
K
I
T
---
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
---
E
H
----
L
-----
L
R
L
----
P
-
V
K
P
S
M
V
L
N
L
-
S
K
G
I
E
--
I
K
--
T
G
-
K
R
V
-
S
E
I
V
E
E
I
L
G
C
P
----
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
----------
P
T
A
V
T
L
A
G
E
N
---
S
K
E
L
Q
K
R
I
S
--
T
--
E
Y
F
R
V
Y
T
---
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
G
--
A
D
---
Q
---
K
T
F
M
G
L
A
-
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
-
R
-
G
F
N
P
L
K
L
L
----
E
S
S
---
N
Q
V
V
E
G
A
--
F
T
V
K
A
V
M
K
--
I
A
K
E
---
N
K
I
--
D
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
-
R
D
L
M
R
-------------
7
PsiBlast_PDB
89.94
35%
-109
- C1 -
1M67
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
------
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
45
Fugue
89.23
33%
-102
* C1 *
1EVY
1
GPDA_LEIME
A:
[9-357]
KD
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
----
S
G
G
N
L
I
A
Y
A
----
K
-
E
K
Q
V
P
V
L
V
C
-
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
---
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
---
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----------
R
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
-
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
LFK
5
PsiBlast_PDB
89.18
35%
-109
- C1 -
1JDJ
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
------
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
9
PsiBlast_PDB
88.97
35%
-109
- C1 -
1N1G
3
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
------
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
6
PsiBlast_PDB
88.85
35%
-107
- C1 -
1M66
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
------
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
3
PsiBlast_PDB
88.74
35%
-110
- C1 -
1EVY
1
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
------
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
4
PsiBlast_PDB
88.73
35%
-108
- C1 -
1EVZ
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
------
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
22
PsiBlast_CBE
88.41
35%
-105
- C1 -
1N1E
1
GPDA_LEIME
B:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SGGN
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
CWA
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
T
S
---
K
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
8
PsiBlast_PDB
88.34
35%
-104
- C1 -
1N1E
1
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
-----
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
-
R
I
M
--
S
--
T
G
D
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
T
S
---
K
A
V
A
E
G
V
--
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
26
HHSearch
88.05
33%
-104
- C1 -
1EVY
1
GPDA_LEIME
A:
[13-344]
----
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
-------
L
S
-------
K
K
C
------
R
E
V
C
V
--
W
H
------------
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
----
S
-----
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
-
T
K
G
I
E
--
R
S
--
T
L
-
K
F
P
-
A
E
I
I
G
E
F
L
P
---
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
----------
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
--
T
GD
R
S
F
V
C
W
A
---
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
--
G
D
---
G
---
S
A
V
F
G
L
A
-
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
---
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
-
A
D
L
L
S
-------------
29
HHSearch
87.14
30%
-99
- C1 -
1X0V
7
GPDA_HUMAN
A:
[7-353]
-----
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
-------
V
G
G
N
A
A
Q
L
A
Q
F
D
------
P
R
V
T
M
--
W
V
------------
F
E
E
-----
D
I
GGKK
L
T
E
I
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
----
L
-----
K
G
H
----
L
-
K
A
N
A
T
G
I
S
L
-
I
K
G
V
D
--
E
G
PN
G
L
-
K
L
I
-
S
E
V
I
G
E
R
L
G
----
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
----------
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
---
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
C
--
S
G
PVS
S
---
A
T
F
L
E
S
C
-
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
-
R
T
G
K
S
I
E
Q
L
E
K
E
LL
N
-----
G
Q
K
L
Q
G
P
--
E
T
A
R
E
L
Y
S
--
I
L
Q
H
---
K
G
L
VD
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
-
H
C
L
Q
N
H
P
E
H
---------
10
PsiBlast_PDB
83.58
30%
-95
- C1 -
1WPQ
6
GPDA_HUMAN
A:
[2-342]
-----
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
A
A
Q
L
A
-------
Q
F
D
------
P
R
V
T
M
--
W
V
------------
F
E
E
DIGGK
K
L
-----
T
E
I
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
----
L
-----
K
G
H
----
L
-
K
A
N
P
T
G
I
S
L
-
I
K
G
V
D
--
E
G
--
P
N
G
L
K
L
I
S
E
V
I
G
E
R
L
G
I
P
----
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
----------
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
---
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
C
--
S
G
---
P
VS
S
A
T
F
L
E
S
C
-
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
-
R
-
T
G
K
S
I
E
Q
L
----
E
K
E
L
LN
G
Q
K
L
Q
G
P
--
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
---
L
V
D
--
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
-
H
C
L
---------------
13
PsiBlast_PDB
83.44
29%
-106
- C1 -
4FGW
-
GPD1_YEAST
A:
[36-383]
--------
K
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
-------
V
A
-------
E
N
C
K
G
Y
P
EV
F
A
P
I
V
Q
M
W
V
F
E
E
E
I
-------
N
G
E
-----
K
L
-----
T
E
I
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
R
I
C
S
Q
----
L
-----
K
G
H
----
V
-
D
S
H
V
R
A
I
S
C
-
L
K
G
F
E
V
G
A
K
--
G
V
-
Q
L
L
-
S
S
Y
I
T
E
E
L
G
I
Q
----
C
G
A
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
Y
H
I
P
K
D
F
R
G
E
G
K
D
V
D
H
-
K
V
L
K
A
L
F
H
--
R
--
P
Y
F
H
V
S
V
---
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
---
I
R
F
G
Q
M
F
F
PE
S
R
---
E
---
E
T
Y
Y
Q
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
V
A
R
L
M
A
T
S
-
G
K
D
A
W
E
C
E
----
K
E
L
LN-
G
Q
S
A
Q
G
L
--
I
T
C
K
E
V
H
E
--
W
L
E
T
---
C
G
S
VE
D
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
N
L
P
-
D
M
I
---------------
14
PsiBlast_PDB
82.87
29%
-102
- C1 -
2PLA
3
GPD1L_HUMAN
A:
[7-344]
--------
K
V
C
I
V
G
S
G
N
W
G
S
A
V
A
K
I
-------
I
G
-------
N
N
V
------
K
K
L
Q
K
--
F
A
S
T
V
K
M
W
V
F
E
E
T
V
N
G
R
-----
K
L
-----
T
D
I
I
N
N
D
H
E
N
V
K
Y
L
P
G
H
K
L
P
E
N
V
V
A
M
S
N
L
S
E
A
V
Q
D
A
D
L
L
V
F
V
I
P
H
Q
F
I
H
R
I
C
D
E
----
I
-----
T
G
R
----
V
-
P
K
K
A
L
G
I
T
L
-
I
K
G
I
D
E
G
P
E
--
G
L
-
K
L
I
-
S
D
I
I
R
E
K
M
G
I
D
----
I
S
V
L
M
G
A
N
I
A
N
E
V
A
A
E
K
----------
F
C
E
T
T
I
G
S
K
V
M
E
N
G
L
L
F
K
E
L
L
Q
--
T
--
P
N
F
R
I
T
V
---
V
D
D
A
D
T
V
E
L
C
G
A
L
K
N
I
V
A
V
G
A
G
F
C
D
G
L
R
C
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
R
I
F
C
K
G
Q
--
V
S
---
T
---
A
T
F
L
E
S
C
-
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
R
V
A
E
A
F
A
-
R
T
G
K
T
I
E
E
L
E
----
K
E
M
LN-
G
Q
K
L
Q
G
P
--
Q
T
S
A
E
V
Y
R
--
I
L
K
Q
K
GL
L
D
---
K
F
P
L
F
T
A
V
Y
Q
I
C
Y
E
S
R
P
V
Q
E
M
L
-
S
C
L
---------------
11
PsiBlast_PDB
82.71
30%
-96
- C1 -
1X0X
6
GPDA_HUMAN
A:
[6-347]
----
M
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
A
A
Q
L
A
-------
Q
F
D
------
P
R
V
T
M
--
W
V
------------
F
E
E
D
I
GGK
K
L
-----
T
E
I
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
----
L
-----
K
G
H
----
L
-
K
A
N
A
T
G
I
S
L
-
I
K
G
V
D
--
E
G
--
P
N
G
L
K
L
I
S
E
V
I
G
E
R
L
G
I
P
----
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
----------
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
---
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
C
--
S
G
---
P
VS
S
A
T
F
L
E
S
C
-
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
-
R
-
T
G
K
S
I
E
Q
L
----
E
K
E
L
LN
G
Q
K
L
Q
G
P
--
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
---
L
V
D
--
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
-
H
C
L
---------------