@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1942: (2016-03-30 )
VNLEKELKEYLGFDEFRPGQKEVIETALAKQNCFAMLPTGTGKTICYQLAGHLMDGLVLIVSPLLSLMQDQMERMRAHGEKRVAALNSFLKREEKGQILASIHSYKFIFLSPEMLNNETVKNLLLKQKISLFVIDEAHCISQWGHDFRPDYLMLGRFIQEAKFPVTMVLTATATKKVRADILTQLHLTDCAQIVYSVNRPNISLQVEKFSNQHVKKDRLYELVRKLQTPGIIYFSSKKLAESTAHELSEIAELRVAYYHGDMDTEDRIIIQQQFVYGQLDVICATSAFGMGIDKADIRYVIHYHMPADLEAYLQEIGRAGRDGEDSVAILLYANGDEFIQMQLADQDIPDANLMNLTTEQRKTLPETEQRFIDYYQRSGLSTKELTDKMDYRKKWKRANLQQFIGYLHTTDCRRNYILRYFEEAPLEVTPENCCDLDGAEIINFEKRAKIKQKEIPTWEAYLAYLLQ
Atome Classification :
(20 SA)
.........10........20........30........40........50------........60........70......--------..80...-.....90........100---.----..--.....110......-----.-120--.......-----..130.......140.......150.......160..--..--..--.170.......180.......190.......200.-..-.-...----210-.......220.--..--..----.--.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330......-.340.......350.......360.......370.......380.......390.......400.......-410.......420.......430.......440.......450.......460.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
V
N
L
E
K
E
L
K
E
YLG
F
D
EFRP
G
Q
K
E
V
I
E
T
A
L
AKQ
N
C
F
A
M
LPTGT
G
K
T
I
C
Y
Q
L
A
G
------
H
L
M
D
G
L
V
L
I
V
S
P
L
L
S
L
M
Q
D
Q
M
E
R
M
R
A--------HG
E
K
R
V
A
-
A
L
N
S
F
L
K
R
E
EK
G
Q
I
L
A
S----I----HS--
Y
K
F
I
F
L
S
P
E
ML
N
N
E
-----
T
-
V
----
K
N
L
L
L
K
Q-----K
I
S
L
F
V
IDE
A
H
C
I
S
QWGHDFR
P
D
Y
L
M
L
G
R
F
I
Q
EAKF
P
--
V
T
--
M
V
--
L
TATA
T
K
K
V
R
A
D
I
L
T
Q
L
H
L
T
D
C
A
Q
I
V
Y
SVNRP
N
I
S
-
L
Q
-
V
-EKF----SNQ-HV
K
K
D
R
L
Y
E
L
V
--
R
K
--LQ----T--P
G
I
I
Y
FSS
K
K
L
A
E
S
T
A
H
E
L
S
E
I
A
E
L
R
V
A
Y
Y
HGDMDTE
D
R
I
I
I
Q
Q
QFVYG
Q
L
D
V
I
C
AT
S
A
FGMGIDKA
D
I
R
Y
V
I
H
YHMPA
D
L
E
A
Y
L
Q
E
I
G
RAGRDGED
S
V
A
I
L
L
YANGD
E
F
-
I
Q
M
Q
LADQDIPDA
N
L
M
NL
T
T
E
Q
R
KTL
P
E
T
E
Q
R
F
I
D
Y
Y
Q
RSGL
S
T
K
E
L
T
D
K
M
D
Y
R
K
K
W
K
RA
N
L
Q
Q
F
I
G
Y
L
HT-
T
D
C
R
R
N
Y
I
L
R
Y
F
E
EAPLEVTPENCCDLD
G
A
E
II
N
F
E
K
R
AKIKQKEIP
T
W
E
A
Y
L
A
Y
LLQ
63
HHSearch
97.69
36%
-117
- C7 -
1OYW
2
RECQ_ECOLI
A:
[12-409]
-
G
A
K
Q
V
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
------
L
L
L
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
--------
N
G
V
A
-
A
A
-
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
C
R
--
T
----
G
Q
--
I
R
L
L
Y
I
A
P
E
R
L
M
L
D
-----
N
-
F
----
L
E
H
L
A
H
W
-----
N
P
V
L
L
A
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
R
Q
R
F
P
T
L
--
P
F
--
M
A
--
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
I
Q
I
S
S
F
D
R
P
N
I
R
-
Y
M
-
L
-
M
E
K
----
F
K
----
P
L
D
Q
L
M
R
Y
V
--
Q
E
Q
-
R
G
----
K
--
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
-
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
M
A
-
W
L
R
R
C
L
E
E
K
P
Q
G
----------------------------------------
Q
L
Q
D
I
E
R
H
K
L
N
A
M
G
A
F
A
E
A
-
Q
T
C
R
R
L
V
L
L
N
Y
F
G
E
G
R
Q
--
E
P
C
G
N
C
D
I
C
L
D
P
P
K
Q
------------------------
62
HHSearch
92.47
32%
-118
- C7 -
2V1X
6
RECQ1_HUMAN
A:
[31-437]
-
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--------
L
G
I
S
-
A
T
-
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
M
V
NK
N
----
S
E
--
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
-----
K
M
F
M
S
R
L
E
K
A
Y
E
A
R
-----
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
--
S
L
--
I
G
--
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
-
Y
E
-
V
-
R
Q
K
----
P
S
N
T
E
D
F
I
E
D
I
V
K
L
I
--
N
G
R
Y
K
G
----
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
-
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
-
R
I
S
S
M
V
V
M
E
----------------------------------------------
N
V
G
Q
Q
K
L
Y
E
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
---
A
C
N
K
M
C
D
N
C
C
K
D
S
A
F
------------------------
5
PsiBlast_PDB
91.51
33%
-124
- C7 -
4Q48
1
?
A:
[16-403]
------
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
------
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
--------
N
G
-
V
R
A
A
-
F
L
N
S
T
L
L
P
H
E
A
R
E
V
E
D
A
----
L
L
R
--
G
D
--
L
D
L
L
Y
V
A
P
E
R
L
L
M
P
-----
R
-
T
----
L
D
L
L
E
R
A
-----
P
V
A
L
F
A
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
--
R
F
P
E
L
P
R
--
V
A
--
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
-
Y
R
-
V
--------
G
L
K
-
D
S
P
K
T
Q
L
L
H
F
I
--
R
E
--
E
H
----
P
G
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
-
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
E
E
G
V
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
Q
S
D
A
P
E
E
V
----------------------------------------
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
E
L
S
E
--
P
C
G
N
C
D
V
-------------------------------
2
PsiBlast_PDB
91.41
39%
-136
- C7 -
4TMU
-
?
A:
[37-364]
------
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
A
T
I
I
D
A
V
L
E
G
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
------
L
V
K
T
G
L
T
I
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
L
A
--------
N
G
V
A
-
A
A
-
C
L
N
S
T
Q
S
R
E
E
Q
Q
A
V
L
A
G
----
C
----
R
T
GQ
V
R
L
L
Y
I
A
P
E
R
L
M
M
D
-----
N
-
F
----
I
D
T
L
G
Y
W
-----
D
L
A
M
V
A
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
--
R
A
R
F
P
--
A
V
P
F
M
A
--
L
T
A
T
A
D
D
T
T
R
R
D
I
V
R
L
L
G
L
D
D
P
L
I
E
I
S
S
F
D
R
P
N
I
R
Y
M
L
-
M
-
E
K
F
----
K
P
--------
L
D
Q
L
M
--
R
Y
--
V
Q
E
Q
RG
K
--
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
R
G
-
I
S
A
A
A
Y
H
A
G
L
E
H
E
V
R
A
S
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
-------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.00
38%
-138
- C7 -
1OYW
1
RECQ_ECOLI
A:
[17-344]
------
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
------
L
L
L
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
--------
N
G
V
A
-
A
A
-
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
----
C
----
R
T
GQ
I
R
L
L
Y
I
A
P
E
R
L
M
L
D
-----
N
-
F
----
L
E
H
L
A
H
W
-----
N
P
V
L
L
A
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
R
Q
--
R
F
P
--
T
L
P
F
M
A
--
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
I
Q
I
S
S
F
D
R
P
N
I
R
-
Y
M
-
L
M
E
K
F
----
K
-----
P
L
D
Q
L
M
R
Y
V
--
Q
E
--
Q
R
G---
K
--
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
G
-
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
-------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
89.51
33%
-119
- C7 -
4Q48
1
?
B:
[16-403]
------
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
------
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
--------
N
G
-
V
R
A
A
-
F
L
N
S
T
L
L
P
H
E
A
R
E
V
E
D
A
----
L
LR--
G
D
--
L
D
L
L
Y
V
A
P
E
R
L
L
M
P
-----
R
-
T
----
L
D
L
L
E
R
A
-----
P
V
A
L
F
A
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
--
R
F
P
EL
P
R
--
V
A
--
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
-
Y
R
-
V
--------
G
L
K
-
D
S
P
K
T
Q
L
L
H
F
I
--
R
E
--
E
H
----
P
GD
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
-
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
E
E
G
V
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
Q
S
D
A
P
E
E
V
----------------------------------------
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
E
L
S
E
--
P
C
G
N
C
D
V
-------------------------------
22
PsiBlast_CBE
89.45
33%
-123
- C7 -
4Q47
3
?
B:
[16-403]
------
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
------
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
--------
N
G
-
V
R
A
A
-
F
L
N
S
T
L
L
P
H
E
A
R
E
V
E
D
A
----
L
L
R
--
G
D
--
L
D
L
L
Y
V
A
P
E
R
L
L
M
P
-----
R
-
T
----
L
D
L
L
E
R
A
-----
P
V
A
L
F
A
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
--
R
F
P
E
L
P
R
--
V
A
--
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
-
Y
R
-
V
--------
G
L
K
-
D
S
P
K
T
Q
L
L
H
F
I
--
R
E
--
E
H
----
P
G
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
-
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
E
E
G
V
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
Q
S
D
A
P
E
E
V
----------------------------------------
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
E
L
S
E
--
P
C
G
N
C
D
V
-------------------------------
4
PsiBlast_PDB
88.55
33%
-127
- C7 -
4Q47
2
?
A:
[16-403]
------
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
------
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
--------
N
G
-
V
R
A
A
-
F
L
N
S
T
L
L
P
H
E
A
R
E
V
E
D
A
----
L
L
R
--
G
D
--
L
D
L
L
Y
V
A
P
E
R
L
L
M
P
-----
R
-
T
----
L
D
L
L
E
R
A
-----
P
V
A
L
F
A
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
--
R
F
P
E
L
P
R
--
V
A
--
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
-
Y
R
-
V
--------
G
L
K
-
D
S
P
K
T
Q
L
L
H
F
I
--
R
E
--
E
H
----
P
G
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
-
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
E
E
G
V
I
V
C
A
T
V
A
----
I
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
Q
S
D
A
P
E
E
V
----------------------------------------
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
E
L
S
E
--
P
C
G
N
C
D
V
-------------------------------
1
PsiBlast_PDB
86.06
39%
-137
- C7 -
1OYY
2
RECQ_ECOLI
A:
[17-344]
------
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
------
L
L
L
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
--------
N
G
V
A
-
A
A
-
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
----
C
----
R
T
GQ
I
R
L
L
Y
I
A
P
E
R
L
M
L
D
-----
N
-
F
----
L
E
H
L
A
H
W
-----
N
P
V
L
L
A
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
R
Q
--
R
F
P
--
T
L
P
F
M
A
--
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
I
Q
I
S
S
F
D
R
P
N
I
R
Y
M
L
-
M
-
E
K
F
----
K
P
--------
L
D
Q
L
M
--
R
Y
--
V
Q
E
Q
RG
K
--
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
G
-
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
----
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
-------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.17
38%
-107
- C7 -
4CDG
1
B:
[30-398]
----------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
DI
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
Y
L
Q
L
S
K
K
D
P
I
I
----------------
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
R
L
I
S
T
-
L
----
E
N
L
Y
E
R
K
-----
L
L
A
R
F
V
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
Q
D
Y
K
R
M
N
M
L
R
Q
--
K
F
P
--
S
V
P
V
M
A
--
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
-
Y
Y
-
V
-
L
P
K
----
K
P
K
-
K
V
A
F
D
C
L
-
E
W
I
--
R
K
--
H
H
----
P
Y
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.15
38%
-108
- C7 -
4O3M
9
A:
[24-388]
----------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
DI
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
Y
L
Q
L
S
K
K
D
P
I
I
----------------
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
R
L
I
S
T
-
L
----
E
N
L
Y
E
R
K
-----
L
L
A
R
F
V
I
D
E
A
H
---------
R
Q
D
Y
K
R
M
N
M
L
R
Q
--
K
F
P
--
S
V
P
V
M
A
--
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
-
Y
Y
-
V
-
L
P
K
----
K
P
K
-
K
V
A
F
D
C
L
-
E
W
I
--
R
K
--
H
H
----
P
Y
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
-------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.13
38%
-108
- C7 -
4CDG
1
BLM_HUMAN
A:
[30-391]
----------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
DI
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
Y
L
Q
L
S
K
K
D
P
I
I
----------------
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
R
L
I
S
T
-
L
----
E
N
L
Y
E
R
K
-----
L
L
A
R
F
V
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
Q
D
Y
K
R
M
N
M
L
R
Q
--
K
F
P
--
S
V
P
V
M
A
--
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
-
Y
Y
-
V
-
L
P
K
----
K
P
K
-
K
V
A
F
D
C
L
-
E
W
I
--
R
K
--
H
H
----
P
Y
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
-------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.07
38%
-107
- C7 -
4CGZ
3
A:
[30-389]
----------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
DI
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
Y
L
Q
L
S
K
K
D
P
I
I
----------------
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
R
L
I
S
T
-
L
----
E
N
L
Y
E
R
K
-----
L
L
A
R
F
V
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
Q
D
Y
K
R
M
N
M
L
R
Q
--
K
F
P
--
S
V
P
V
M
A
--
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
-
Y
Y
-
V
-
L
P
K
----
K
P
K
-
K
V
A
F
D
C
L
-
E
W
I
--
R
K
--
H
H
----
P
Y
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
-------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.99
35%
-115
- C7 -
2V1X
4
RECQ1_HUMAN
A:
[36-380]
------
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--------
L
G
-
I
S
A
T
-
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
----
M
V
NKN
S
E
--
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
-----
K
-
M
----
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
--
I
L
K
R
Q
F
P
--
N
A
--
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
-
Y
E
-
V
R
Q
K
P
----
S
N
T
-
E
D
F
I
E
D
I
V
K
L
I
N
G
R
Y
--
K
G
----
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
-
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
-----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.63
35%
-114
- C7 -
4U7D
-
RECQ1_HUMAN
A:
[36-380]
------
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--------
L
G
-
I
S
A
T
-
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
----
M
V
NKN
S
E
--
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
-----
K
-
M
----
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
--
I
L
K
R
Q
F
P
--
N
A
--
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
-
Y
E
-
V
R
Q
K
P
----
S
N
T
-
E
D
F
I
E
D
I
V
K
L
I
N
G
R
Y
--
K
G
----
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
-
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
-----------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
82.35
35%
-118
- C7 -
2WWY
6
RECQ1_HUMAN
B:
[36-377]
------
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--------
L
G
-
I
S
A
T
-
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
----
M
V
NKN
S
E
--
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
-----
K
-
M
----
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
--
I
L
K
R
Q
F
P
--
N
A
--
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
-
Y
E
-
V
R
Q
K
P
----
S
N
T
-
E
D
F
I
E
D
I
V
K
L
I
N
G
R
Y
--
K
G
----
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
-
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
-----------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.02
35%
-115
- C7 -
2WWY
5
RECQ1_HUMAN
A:
[36-377]
------
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--------
L
G
-
I
S
A
T
-
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
----
M
V
NKN
S
E
--
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
-----
K
-
M
----
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
--
I
L
K
R
Q
F
P
--
N
A
--
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
-
Y
E
-
V
R
Q
K
P
----
S
N
T
-
E
D
F
I
E
D
I
V
K
L
I
N
G
R
Y
--
K
G
----
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
-
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
-----------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
81.02
35%
-111
- C7 -
2V1X
8
RECQ1_HUMAN
B:
[36-380]
------
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
------
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--------
L
G
-
I
S
A
T
-
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
----
M
VNKN
S
E
--
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
-----
K
-
M
----
F
M
S
R
L
E
K
AYEAR
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
--
I
L
K
R
Q
F
P
--
N
A
--
S
L
IG
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
-
Y
E
-
V
R
Q
K
P
----
S
N
T
-
E
D
F
I
E
D
I
V
K
L
I
NG
R
Y
--
K
G
----
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
-
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
-----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.39
23%
-94
- C7 -
3EX7
4
IF4A3_HUMAN
C:
[57-385]
-----------
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
LDI
Q
V
R
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
--------
L
G
D
Y
M
N
V
-
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
----
L
D
---
Y
G
--
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
-----
I
-
R
----
R
R
S
L
R
T
R
-----
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
--
F
K
E
Q
I
Y
D
V
Y
R
Y
L
P
----
P
--
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
--
V
K
R
D
E
L
T
-
L
E
G
I
-
K
Q
F
F
V
A
V
E
R
E
-
E
W
K
F
D
T
L
C
D
L
Y
--
D
T
--
L
T
I---
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
-
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.85
23%
-95
- C7 -
2J0S
3
IF4A3_HUMAN
A:
[56-384]
-----------
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
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