@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1947: (2016-03-30 )
MKIWNSIVGKIWSTIILLLIGILVISGFLVAMIYEKNNITRITNELEDKTASIITVMQENNEVISAENNNDSALILLDDTMGVIIEQNGKSVYQSQSPDTISSASANKLIQDKTLDKALEKDNSVTMKYNFKTEKSSLPVEISAQKFKLANGETGVVYVYQSYHDILKVNEKTMSTLIISGIIAIVITSILSFVFSSRMAFPLREMKKIAIAVSKGNFDNRVPTYTHDEIGELGVAFNDMAKQLKYNVSALRQEKEQLSNILVGMADGVIKFSVDKTIILSNPPAEEFLHNWFFSPENTEKVLIPVALNELLNDTLEKKESQVGEITFADHTYVAILTLLYTGEHVRSIVAVIRDMTEEKQLEKMKSDFVNNVSHELRTPISMLQGYSEAIIDGVAQSDEEVREFAQIIYDESLRIGRLVNDMLDLARMEAGFNQMDNQKLPLAPLLRKVISNFDVLAKENFVELGLELETPDLEYSYDPDRMEQVLINLIMNAIRHTGKEGYDGKVILKQTIDVARSNLVITVSDNGSGIAEEDIPYLFERFYKVDKARKRGKAVGTGIGLAIVKNIVEAHNGKISVESELGKGSDFIITLPLYK
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290...-....300.....-..310.......320....-.....330-.......-----340..----.--....350.......360.------.------.---------....370.......380.......390-......----..-400.......410.......420.......430.......440-----.........450.......460----..---....-----..--470-.--.-.....480.......490.......500.----......510.......520.......530.......540......------.550.......560.......570........580.......590....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
W
N
S
I
V
G
K
I
W
S
T
I
I
L
L
L
I
G
I
L
V
I
S
G
F
L
V
A
M
IYEKN
N
I
T
R
I
T
N
E
LEDK
T
A
S
I
I
T
V
M
QEN
N
E
V
I
S
AENNN
D
S
A
L
I
L
LDDT
M
G
V
I
I
EQNGKSVYQSQSPDTISSASANKLI
Q
D
K
T
L
D
K
A
L
EKDN
S
V
T
M
K
Y
N
FKTEKSSL
P
V
E
I
S
A
Q
K
F
K
LANGET
G
V
V
Y
V
Y
Q
S
Y
H
D
I
L
K
V
N
E
K
T
M
S
T
L
I
I
S
G
I
I
A
I
V
I
T
S
I
L
S
F
V
F
SSRMAF
P
L
R
E
M
K
K
I
A
I
A
V
SKGNFDNRVPTY
T
H
D
E
I
G
E
L
G
V
A
F
N
D
M
A
K
Q
L
K
Y
N
V
S
A
L
R
Q
E
K
E
Q
L
S
N
I
L
V
G
MAD
G
V
I
K
F
SVD
K
T
I
I
LSNP
P
A
E
E
F
L
H
N
WFFS-PENT
E
K
V
L
I
P
V
A
-
L
N
E
L
L
N
D
T
L
E
K
K
E--SQVG-
E
I
T
FAD
H
T
-
Y
V
A
I
L
T
L
-----
L
YT
G
E
----
H
--
V
R
S
I
V
A
V
I
R
D
M
T
E
E
K
Q
L
E
------
K
------
M
---------
K
S
D
F
V
N
N
V
S
H
E
L
R
T
P
I
S
M
L
Q
G
Y
S
E
A
I
--
I
D
GVAQ----S
D
-
E
E
V
R
E
F
A
Q
I
I
Y
DESL
R
I
G
R
L
V
N
D
M
L
D
L
A
R
M
E
A
GFNQMDNQK-------L
P
L
A
P
L
L
R
K
V
I
SN
F
D
V
L
A
K
E
N
-----
F
V
---
E
LG
L
-----
E
L--ETP-D--L-EYSY
D
P
D
R
M
E
Q
V
L
I
N
L
I
M
N
A
I
R
HTGKEGY----D
G
K
V
I
L
K
Q
T
I
D
VARS
N
L
V
I
T
VSDNGSGI
A
E
E
D
I
P
Y
L
F
E
R
F
Y
K
V
D
K
------
A
R
KRGKAVGT
G
I
G
L
A
I
V
K
N
I
V
E
-AHN
G
K
I
S
V
E
SELGKGS
D
F
I
I
TLPLYK
3
PsiBlast_PDB
80.15
35%
-80
- C2 -
4U7O
1
?
A:
[25-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
------
N
------
D
---------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
--
S
D
G
A
W
K
----
D
P
-
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
-------
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
DNPA
K
Y
Y
---
T
I
K
R
-----
E
F
--
T
K
R
-
D
--
L
-
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
--------
D
G
G
V
V
T
C
R
L
L
E
-
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----------
Q
G
-
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
22
PsiBlast_CBE
79.16
36%
-75
- C2 -
4JAV
6
?
B:
[5-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
S
K
E
L
E
------
R
L
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
----
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
C
P
--
V
-
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
--
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
-
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---
8
PsiBlast_PDB
79.02
36%
-86
- C2 -
4JAU
1
?
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
------
R
L
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
--
Y
N
S
L
G
E
----
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
C
P
--
V
-
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
--
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
----------------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---
7
PsiBlast_PDB
78.51
36%
-80
- C2 -
4JAS
2
?
A:
[13-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKR
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
--
Y
N
S
L
G
E
----
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
C
P
--
V
-
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
--
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
-
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---
39
HHSearch
78.04
37%
-91
- C2 -
2C2A
2
?
A:
[2-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
R
------
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
L---
D
L
-
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
-
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
K
V
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
----------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-
5
PsiBlast_PDB
76.46
36%
-72
- C2 -
4JAV
6
?
A:
[3-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
E
------
R
L
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
----
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
C
P
--
V
-
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
--
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
-
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---
4
PsiBlast_PDB
75.61
36%
-72
- C2 -
3DGE
3
?
A:
[14-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KR
I
D
R
-
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
----
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
C
P
--
V
-
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
--
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
-
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---
1
PsiBlast_PDB
74.73
31%
-62
- C2 -
4I5S
-
?
A:
[54-432]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
-------
V
T
R
E
Q
A
L
E
C
N
I
-
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
-
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
----
S
GF
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
------
R
------
E
---------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
--
D
D
G
-
A
L
----
T
E
-
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
-------
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
-----
S
T
------------
E
I
I
R
D
Y
P
-
D
K
S
V
-
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
-
P
D
G
------
G
K
V
T
I
--
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
------
A
R
--------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---
23
PsiBlast_CBE
74.52
36%
-70
- C2 -
3DGE
2
?
B:
[14-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRIDR-
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
----
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
C
P
--
V
-
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
--
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
-
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---
6
PsiBlast_PDB
73.96
36%
-82
- C2 -
2C2A
2
?
A:
[1-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
V
T
E
S
K
E
L
E
------
R
L
K
R
I
D
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
----
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
-----
N
V
---
N
V
L
F
-----
E
S
--
N
V
P
C
P
--
V
-
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
----
D
K
Y
V
--
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
----------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---
21
PsiBlast_CBE
73.63
35%
-69
- C2 -
4U7O
1
?
B:
[37-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
--
S
D
G
A
W
K
----
D
P
-
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
L
-------
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
DNPAK
Y
Y
---
T
I
K
R
-----
E
F
--
T
K
R
-
D
--
L
-
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
--------
D
G
G
V
V
T
C
R
L
L
E
-
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
------
A
R
---
Q
G
-
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
2
PsiBlast_PDB
72.57
35%
-82
- C2 -
4U7N
-
?
A:
[39-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
--
S
D
G
A
W
K
----
D
P
-
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
-------
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
DN---
Y
Y
---
T
I
K
R
-----
E
F
--
T
K
R
-
D
--
L
-
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
--------
D
G
G
V
V
T
C
R
L
L
E
-
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
------------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
59
Fugue
72.04
28%
-54
- C2 -
4I5S
-
?
A:
[37-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
-
A
L
E
C
N
I
L
D
I
L
D
D
-
D
S
Y
T
Y
N
D
L
I
T
K
T
P
--
E
I
V
L
-
T
R
R
D
E
Y
D
E
-
F
I
T
L
R
I
R
-----
F
A
L
N
R
RESG
F
--
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
------
R
------
E
---------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
--
D
D
G
-
A
L
----
T
E
-
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
-----
H
L
D
V
E
L
-------
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
-----
S
T
---
E
I
I
R
-----
D
Y
--
P
D
K
-
S
--
V
-
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---------
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
------
A
R
--------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---
9
PsiBlast_PDB
69.00
32%
-80
- C2 -
4Q20
-
DIVL_CAUCR
A:
[35-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
E
------
R
------
L
---------
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
--
S
--------
E
R
G
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
A
L
E
I
E
D
-------
I
R
V
S
D
L
L
L
N
A
Q
E
R
A
L
K
D
A
Q
L
G
-----
G
V
---
T
L
A
V
-----
E
C
--
E
E
D
-
V
--
G
-
L
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
-------
G
G
R
V
T
L
--
S
A
R
R
A
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
R
------
G
-------
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
---
37
HHSearch
64.23
25%
-71
- C2 -
3A0R
1
?
A:
[9-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
S
V
F
E
N
K
E
--
P
V
F
L
N
F
Y
K
F
G
E
R
Y
-
F
N
I
R
F
S
P
-----
F
R
N
A
K
TQ--
L
--
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
------
E
------
E
R
K
R
R
E
R
L
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
--
K
K
H
L
D
D
-----
P
-
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
----
V
L
E
F
T
E
-------
F
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
M
-----
N
I
---
D
F
C
F
-----
E
T
--
D
N
E
-
D
--
L
-
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
K
----
I
---
K
I
T
S
E
--
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
-------------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
-
16
PsiBlast_PDB
62.53
28%
-62
- C2 -
4CB0
6
CPXA_ECOLI
A:
[70-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
----------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
----
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
-
N
A
L
V
S
E
T
-------
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
-----
G
K
---
S
L
T
V
-----
N
F
--
P
P
G
-
P
--
W
-
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----------
H
T
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
------
A
R
D
R
-
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
41
HHSearch
62.17
20%
-80
- C2 -
2Q8G
1
PDK1_HUMAN
A:
[104-366]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
A
---------
I
Y
D
F
T
D
T
V
I
R
I
R
N
R
H
N
D
V
I
P
T
M
A
Q
G
V
--
I
E
Y
K
E
S
FDPV
T
S
-
Q
N
V
Q
Y
F
L
D
R
F
Y
M
S
R
I
S
I
R
M
L
L
N
Q
H
S
L
L
F
G
----------
K
H
IGSINPN
C
N
V
L
E
V
I
K
D
G
Y
E
N
A
R
R
L
C
D
L
Y
-----
Y
I
N
S
P
E
L
E
L
E
E
L
NA
K
S
--
P
G
Q
-
P
--
I
-
Q
V
V
Y
V
P
S
H
L
Y
H
M
V
F
E
L
F
K
N
A
M
R
A
T
M
E
H
H
A
NRG
V
Y
P
P
I
Q
V
H
V
T
--
L
G
N
E
D
L
T
V
K
M
S
D
R
G
G
G
V
P
L
R
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
RPRVET
S
R
A
V
-
P
L
A
G
F
G
Y
G
L
P
I
S
R
L
Y
A
Q
-
Y
F
Q
G
D
L
K
L
Y
S
L
E
G
Y
G
T
D
A
V
I
Y
I
K
A
L
-
12
PsiBlast_PDB
61.90
28%
-67
- C2 -
4BIX
3
CPXA_ECOLI
A:
[70-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
----------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
----
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
-
N
A
L
V
S
E
T
-------
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
-----
G
K
---
S
L
T
V
-----
N
F
--
P
P
G
-
P
--
W
-
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----------
H
T
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
44
HHSearch
61.35
32%
-82
- C2 -
3A0Y
-
?
A:
[607-751]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
-------
F
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
M
-----
N
I
---
D
F
C
F
-----
E
T
--
D
N
E
-
D
--
L
-
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
K
----
I
---
K
I
T
S
E
--
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
K
---------------
G
T
G
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
-
11
PsiBlast_PDB
61.00
28%
-61
- C2 -
4BIW
5
CPXA_ECOLI
A:
[70-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
----------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
----
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
-
N
A
L
V
S
E
T
-------
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
-----
G
K
---
S
L
T
V
-----
N
F
--
P
P
G
-
P
--
W
-
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----------
H
T
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
------
A
R
D
R
-
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
46
HHSearch
57.12
37%
-78
- C2 -
3SL2
2
A:
[3-152]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
M
S
L
I
I
D
R
F
E
M
T
K
-
E
Q
----------
E
F
I
R
-----
N
L
--
P
D
R
-
D
--
L
-
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
H
----
V
---
T
F
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------------
L
-
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
-
14
PsiBlast_PDB
54.21
42%
-63
- C2 -
3SL2
2
A:
[12-150]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
D
R
F
E
-
M
T
K
E
Q
----------
E
F
I
R
-----
N
L
--
P
D
R
-
D
--
L
-
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
-
P
E
G
------
G
H
V
T
F
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
-------------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
---