@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1954: (2016-03-30 )
MPDKFKRVHVVVMDSVGIGEAPDAAKFGDFDVDTFGHIAKHVGGLKMPEMGKLGLSNIREIEGIKKAEKPLAYYTKMQEASNGKDTMTGHWEIMGLYIDTPFRVFPDGFPDDLINQIEEKTGRKVIGNKPASGTEIMAELGEEHVKTGALIVYTSADSVLQIAAHEDVVPLEELYEICEFCRKITLDDPYMLGRIIARPFVGEPGAFVRTPNRHDYALKPFKPTVMDALKDGGKDVIAIGKISDIFDGEGVTESIRTKSNMDGMDQFIAVLDKDFNGMSFLNLVDFDALFGHRRDPQGYADALVDFDGRLVEVMEKLTDDDLLIITADHGNDPTYTGTDHTREFVPLLVYSPRFKNGGSELELRKTFADLGATVADNFDVKMPEYGTSFLRDLK
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPDK
F
K
R
V
H
V
V
V
M
DSVGIGEAPDAAKFGDFD
V
D
T
F
G
H
I
A
K
H
VGGLKMPEMGKL
G
L
S
N
I
R
E
I
E
G
I
K
K
AEK
P
L
A
Y
Y
T
K
M
Q
EASNGKDTMTG
H
W
E
I
M
G
L
Y
IDTPFRVFPDGF
P
D
D
L
I
N
Q
I
E
E
KTG
R
K
VIGNKPAS
G
T
E
I
M
A
E
L
G
E
E
H
VKT
G
A
L
I
V
YTSAD
S
V
L
Q
IAAHEDVV
P
L
E
E
L
Y
E
I
C
E
F
C
R
KITLD
D
P
Y
M
L
G
R
I
I
ARPFVGEPG
A
F
V
RTPNRHDYALKPF
K
P
T
V
M
D
A
L
K
DGG
K
D
V
I
A
IGK
I
S
D
IFDGEG
V
T
E
S
I
RTKSNM
D
G
M
D
Q
F
I
A
V
L
DKDFNG
M
S
F
L
N
L
V
D
F
D
A
L
FGHRRDP
Q
G
Y
A
D
A
L
V
DFD
G
R
L
V
E
V
M
E
K
LTDD
D
L
L
I
I
TADHGNDPTYTGTDHTR
E
F
V
P
L
L
V
YSPRFKNGGS
E
L
E
L
R
K
T
F
A
D
LGATVADNFDVKMPEY
G
T
S
F
L
R
DLK
22
PsiBlast_CBE
98.77
73%
-97
- C5 -
3UN3
4
DEOB_BACCR
C:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
24
PsiBlast_CBE
98.65
73%
-95
- C5 -
3UN2
3
DEOB_BACCR
C:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
36
PsiBlast_CBE
98.49
73%
-97
- C5 -
4LRE
3
DEOB_BACCR
C:
[25-414]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
46
PsiBlast_CBE
98.48
73%
-96
- C5 -
3M8W
4
DEOB_BACCR
B:
[7-397]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
23
PsiBlast_CBE
98.43
73%
-98
- C5 -
3UN3
6
DEOB_BACCR
B:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
59
PsiBlast_CBE
98.41
73%
-95
- C5 -
4LRA
3
DEOB_BACCR
C:
[25-414]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
45
PsiBlast_CBE
98.40
73%
-96
- C5 -
3M8W
3
DEOB_BACCR
C:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
50
PsiBlast_CBE
98.34
73%
-96
- C5 -
4LR9
5
DEOB_BACCR
B:
[24-414]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
42
PsiBlast_CBE
98.34
73%
-97
- C5 -
3M8Z
3
DEOB_BACCR
C:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
51
PsiBlast_CBE
98.33
73%
-97
- C5 -
4LR8
3
DEOB_BACCR
C:
[25-414]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
41
PsiBlast_CBE
98.30
73%
-96
- C5 -
3OT9
3
DEOB_BACCR
B:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
49
PsiBlast_CBE
98.26
73%
-96
- C5 -
4LR9
3
DEOB_BACCR
C:
[25-414]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
43
PsiBlast_CBE
98.26
73%
-96
- C5 -
3M8Y
6
DEOB_BACCR
C:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
38
PsiBlast_CBE
98.20
73%
-95
- C5 -
3UO0
3
DEOB_BACCR
C:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
57
PsiBlast_CBE
98.18
73%
-96
- C5 -
4LRB
3
DEOB_BACCR
C:
[25-414]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
40
PsiBlast_CBE
98.05
73%
-95
- C5 -
3OT9
3
DEOB_BACCR
C:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
25
PsiBlast_CBE
98.05
73%
-97
- C5 -
3UN2
4
DEOB_BACCR
B:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
10
PsiBlast_PDB
98.00
73%
-96
- C5 -
3M8Z
4
DEOB_BACCR
B:
[8-397]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
52
PsiBlast_CBE
97.85
73%
-95
- C5 -
4LR8
4
DEOB_BACCR
B:
[25-414]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
58
PsiBlast_CBE
97.82
73%
-97
- C5 -
4LRB
3
DEOB_BACCR
B:
[25-414]
---
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
79
HHSearch
97.79
74%
-96
- C5 -
3OT9
6
DEOB_BACCR
A:
[7-397]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
19
PsiBlast_PDB
97.60
73%
-95
- C5 -
4LRF
7
DEOB_BACCR
A:
[24-414]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
18
PsiBlast_PDB
97.50
73%
-95
- C5 -
4LRB
6
DEOB_BACCR
A:
[24-414]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
9
PsiBlast_PDB
97.50
73%
-96
- C5 -
3OT9
6
DEOB_BACCR
A:
[7-397]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
16
PsiBlast_PDB
97.32
73%
-96
- C5 -
4LR9
5
DEOB_BACCR
A:
[24-414]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
21
PsiBlast_CBE
97.03
74%
-95
- C5 -
3M8Z
7
DEOB_BACCR
A:
[7-397]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
12
PsiBlast_PDB
96.67
73%
-95
- C5 -
3UO0
5
DEOB_BACCR
A:
[7-397]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-
15
PsiBlast_PDB
96.49
73%
-94
- C5 -
4LR8
7
DEOB_BACCR
A:
[24-414]
--
N
K
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
N
G
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
-