@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1970: (2016-03-30 )
MEKKIRTVLGDISKESLGFTYSHEHLWCCPPSVQKDRDFELTDYESSLEELKTFQSIGGQTLVDASTLDYGRDGNKLKTMSEESGVNVLGVTGFNKHIYFPDWVQEESIEQITDRLIYDIEKGMDGSDARAGILKSGSWYNLIHPLENKVTRAVAWAQKETGAPIWLHTEAGTMGQEMLAILEEEGVNMELVAVGHSDRNADPYYHLKLAEKGAYVQFDGCGKVKYYPDSTRVELVKNMLENGFGDKLLISGDMGRKSYLHAYGGGPGFRFIKTKFIPRLLEEGVTEQQIQTIFYDNPANWLAKF
Atome Classification :
(20 SA)
.........10........20....-.------...30.-------------------...--.------------------------------...------40........50----.........60........70........80.....-----...90........100-.........110.......120...----------....130....-...140........150.......160.......170..-.--.....180.......190......-.200.......-.210.......-----------220---------.----....--------...-----------------230------------------.........240-.........250.--......260.-----.------...-----..270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
K
K
I
R
T
V
L
G
D
I
S
K
E
SLG
F
T
YSHE
H
-
L
------WCCPPS-------------------VQK--D------------------------------RDF------ELT
D
Y
E
S
S
L
E
E
-----
L
K
T
F
Q
S
IGG
Q
T
L
VDASTLDYGRDGNKLKTMSEESG
V
-----
N
V
L
G
VTGFNKHIYF---
P
D
WV
Q
E
E
S
I
E
Q
I
T
D
R
L
I
Y
D
I
E
KGMD----------GSD
A
R
A
G
I
LKS-GSWYN-LI
H
P
L
E
N
K
V
T
R
A
V
A
WAQKETGA
P
I
W
L
HTEA-GT-
M
--
G
Q
E
M
L
A
I
L
E
EEGV
N
M
E
L
V
A
VGHSD-RN-AD
P
Y
Y
H
L
K
-
L
AEKG
A
Y
V
Q
FD-----------GC----------G----
K
V
K
Y--------YPD-----------------
S
--------------------
T
R
V
E
L
V
K
N
M
L
---ENGFG
D
K
L
L
I
SGD--MGRK
S
Y
L
H
AY-----G------GGP-----G
F
R
F
I
K
T
K
F
I
P
R
L
L
EEGV
T
E
Q
Q
I
Q
T
I
F
YDN
P
A
N
W
L
AKF
30
HHSearch
92.73
30%
-59
- C3 -
3K2G
4
?
A:
[12-354]
R
S
G
R
I
M
T
V
D
G
P
I
P
S
S
A
L
G
H
T
L
M
H
E
H
-
L
------
Q
N
D
C
R
C
-------------------
W
W
N
--
P
PQEPERQYLAEAPISIEI
L
S
E
L
R
Q
DPFVN
K
H
N
I
------
A
L
D
D
L
D
L
A
I
A
E
-----
V
K
Q
F
A
A
V
G
G
R
S
I
V
D
P
T
C
R
G
I
G
R
D
P
V
K
L
R
R
I
S
A
E
T
G
V
-----
Q
V
V
M
G
A
G
Y
Y
L
A
S
S
M
---
P
E
T
A
A
R
L
S
A
D
D
I
A
D
E
I
V
A
E
A
L
E
G
T
D
----------
G
T
D
A
R
I
G
L
I
G
E
-
I
G
V
S
S
-
D
F
T
A
E
E
E
K
S
L
R
G
A
A
R
A
Q
V
R
T
G
L
P
L
M
V
H
L
P
G
-
W
F
R
L
--
A
H
R
V
L
D
L
V
E
E
E
G
A
D
L
R
H
T
V
L
C
H
M
N
-
P
S
H
M
D
P
V
Y
Q
A
T
-
L
A
Q
R
G
A
F
L
E
F
D
-----------
M
I
----------
G
----
M
D
F
F
YADQG
V
Q
C
P
S
D
-----------------
D
--------------------
E
V
A
R
A
I
L
G
L
A
---
D
H
G
Y
L
D
R
I
L
L
S
H
D
--
V
F
V
K
M
M
L
T
R
Y
-----
G
------
G
-
N
-----
G
Y
A
F
V
T
K
H
F
L
P
R
L
R
R
H
G
L
D
D
A
A
L
E
T
L
M
V
T
N
P
R
R
V
F
D
A
-
25
PsiBlast_CBE
92.52
32%
-65
- C3 -
4LEF
6
PHP_ECOLI
D:
[3-291]
-------------
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
--
N
------------------------------
V
D
C
------
R
L
D
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
I
G
T
S
E
G
-
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
T
-
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
----
K
N
S
Y
--------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
R
S
H
L
K
A
------
N
------
G
G
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
---
26
PsiBlast_CBE
92.20
32%
-65
- C3 -
4LEF
1
PHP_ECOLI
B:
[3-291]
-------------
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
--
N
------------------------------
V
D
C
------
R
L
D
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
I
G
T
S
E
G
-
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
T
-
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
----
K
N
S
Y
--------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
R
S
H
L
K
A
------
N
------
G
G
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
---
27
PsiBlast_CBE
92.01
32%
-64
- C3 -
4LEF
6
PHP_ECOLI
A:
[2-291]
------------
S
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
--
N
------------------------------
V
D
C
------
R
L
D
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
I
G
T
S
E
G
-
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
T
-
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
----
K
N
S
Y
--------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
R
S
H
L
K
A
------
N
------
G
G
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
---
10
PsiBlast_PDB
91.70
29%
-61
- C3 -
1I0D
13
OPD_BREDI
A:
[3-326]
---
R
I
N
T
V
R
G
P
I
T
I
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
R
A
R
A
A
G
V
R
T
I
V
D
V
S
T
F
D
I
G
R
D
V
S
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
----
L
W
F
DP-
P
L
S
M
R
L
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
Y
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
A
A
-
S
Q
-
R
D
-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
A
-
L
A
A
R
G
Y
L
I
G
L
D
-------------------------------
H
--------
I
P
H
-----------------
S
AIGLEDN
A
S
A
S
A
L
LGIRS
W
Q
T
R
A
L
L
I
K
A
L
I
---
D
Q
G
Y
M
K
Q
I
L
V
S
N
D
WL
F
G
F
S
S
Y
V
T
N
I
-----
M
D
V
M
D
R
V
N
P
D
-----
G
M
A
F
I
P
L
R
V
I
P
F
L
R
E
K
G
V
P
Q
E
T
L
A
G
I
T
V
T
N
P
A
R
F
L
S
--
1
PsiBlast_PDB
91.68
32%
-61
- C3 -
4LEF
5
PHP_ECOLI
C:
[3-291]
-------------
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
--
N
------------------------------
V
D
C
------
R
L
D
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
I
G
T
S
E
G
-
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
T
-
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
----
K
N
S
Y
--------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
R
S
H
L
K
A
------
N
------
G
G
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
---
8
PsiBlast_PDB
91.54
29%
-62
- C3 -
1HZY
12
OPD_BREDI
A:
[3-326]
---
R
I
N
T
V
R
G
P
I
T
I
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
R
A
R
A
A
G
V
R
T
I
V
D
V
S
T
F
D
I
G
R
D
V
S
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
----
L
W
F
DP-
P
L
S
M
R
L
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
Y
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
A
A
-
S
Q
-
R
D
-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
A
-
L
A
A
R
G
Y
L
I
G
L
D
-------------------------------
H
--------
I
P
H
-----------------
S
AIGLEDN
A
S
A
S
A
L
LGIRS
W
Q
T
R
A
L
L
I
K
A
L
I
---
D
Q
G
Y
M
K
Q
I
L
V
S
N
D
WL
F
G
F
S
S
Y
V
T
N
I
-----
M
D
V
M
D
R
V
N
P
D
-----
G
M
A
F
I
P
L
R
V
I
P
F
L
R
E
K
G
V
P
Q
E
T
L
A
G
I
T
V
T
N
P
A
R
F
L
S
--
31
HHSearch
91.38
33%
-67
- C3 -
1BF6
6
PHP_ECOLI
A:
[2-291]
-------------
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
--
N
------------------------------
V
D
C
------
R
L
D
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
-
I
G
T
S
E
G
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
T
-
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
----
K
N
S
Y
--------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
R
S
H
L
K
A
N
-----
G
------
G
-
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
Q
--
17
PsiBlast_PDB
91.38
28%
-56
- C3 -
4ZST
2
?
A:
[8-331]
---
R
I
N
T
V
R
G
P
I
T
I
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
R
A
R
A
A
G
V
R
T
I
V
D
V
S
T
F
D
C
G
R
D
V
S
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
L
--
W
V
D
P
---
P
L
S
M
R
L
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
Y
G
I
E
----------
D
T
G
I
R
A
G
I
I
-
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
A
A
-
S
Q
-
R
D
-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
A
-
L
A
A
R
G
Y
L
I
G
L
D
----------------------------
Q
I
P
Y
--------
S
A
I
GLEDN
A
S
A
S
V
L
MGNRS
W
Q
--------------------
T
R
A
L
L
I
K
A
L
I
---
D
Q
G
Y
M
K
Q
I
L
V
S
N
D
WL
F
G
F
S
L
Y
V
T
N
I
-----
M
D
V
M
D
R
V
N
P
D
-----
G
M
A
F
I
P
L
R
V
I
P
F
L
R
E
K
G
V
P
Q
E
T
L
A
G
I
T
V
T
N
P
A
R
F
L
S
--
2
PsiBlast_PDB
91.28
32%
-68
- C3 -
1BF6
6
PHP_ECOLI
A:
[1-290]
------------
S
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
--
N
------------------------------
V
D
C
------
R
L
D
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
I
G
T
S
E
G
-
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
T
-
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
----
K
N
S
Y
--------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
R
S
H
L
K
A
------
N
------
G
G
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
---
53
Fugue
91.23
31%
-69
- C3 -
1BF6
6
PHP_ECOLI
A:
[1-291]
------------
S
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
NV
D
------------------------------
C
R
L
------
D
--
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
I
G
T
S
E
G
-
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
-T
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
KNSY------------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
-
R
S
H
L
K
A
-----
N
------
G
G
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
Q
--
3
PsiBlast_PDB
91.22
34%
-56
- C3 -
3MSR
2
?
A:
[9-329]
-----
R
T
V
L
G
D
I
P
V
E
K
L
G
I
T
D
C
H
D
H
F
I
------
K
N
G
G
P
E
-------------------
V
E
E
--
H
------------------------------
I
D
F
------
L
M
L
N
V
D
A
S
I
K
E
-----
F
K
E
F
I
D
R
G
G
S
T
I
V
T
M
D
P
P
N
V
G
R
D
--
V
L
K
T
L
E
I
A
N
A
V
K
NLG
G
N
V
I
M
S
T
G
F
H
K
A
K
F
Y
DKY
S
S
W
L
A
V
V
P
T
E
E
I
V
K
M
C
V
A
E
I
E
E
G
M
D
EYNYNGP
V
V
K
R
S
K
A
K
A
G
I
I
K
A
-
G
T
G
Y
G
-
A
I
D
R
L
E
L
K
A
L
E
V
A
A
R
T
S
I
L
T
G
C
P
I
L
V
H
T
Q
L
-
G
T
-
M
--
A
L
E
V
A
K
H
L
I
G
F
G
A
N
P
D
K
I
Q
I
S
H
L
N
-
K
N
-
P
D
K
Y
Y
Y
E
K
V
I
K
E
T
G
V
T
L
C
F
D
-----------
G
P
----------
D
----
R
V
K
Y
--------
Y
P
D
-----------------
S
--------------------
L
L
A
E
N
I
K
Y
L
V
---
D
K
G
L
Q
K
H
I
T
L
S
L
D
--
A
G
R
I
L
Y
Q
R
N
Y
-----
G
------
L
T
K
G
K
Q
T
F
G
L
A
Y
L
F
D
R
F
L
P
L
L
K
Q
V
G
V
S
K
E
A
I
F
D
I
L
V
N
N
P
K
R
V
L
A
--
4
PsiBlast_PDB
91.21
28%
-61
- C3 -
3K2G
4
?
A:
[15-348]
---
R
I
M
T
V
D
G
P
I
P
S
S
A
L
G
H
T
L
M
H
E
H
-
L
QNDCRC
W
W
N
P
P
Q
EPERQYLAEAPISIEI
L
S
E
L
R
Q
--
D
PFVN
K
-------------------------
H
N
I
------
A
L
D
D
L
D
L
A
I
A
E
-----
V
K
Q
F
A
A
V
G
G
R
S
I
V
D
P
T
C
R
G
I
G
R
D
P
V
K
L
R
R
I
S
A
E
T
G
V
-----
Q
V
V
M
G
A
G
Y
Y
L
A
S
S
M
---
P
E
T
A
A
R
L
S
A
D
D
I
A
D
E
I
V
A
E
A
L
E
G
T
D
----------
G
T
D
A
R
I
G
L
I
G
E
-
I
G
V
S
S
-
D
F
T
A
E
E
E
K
S
L
R
G
A
A
R
A
Q
V
R
T
G
L
P
L
M
V
H
L
P
G
W
F
R
-
L
--
A
H
R
V
L
D
L
V
E
E
E
G
A
D
L
R
H
T
V
L
C
H
M
N
P
S
H
-
M
D
P
V
Y
Q
A
T
-
L
A
Q
R
G
A
F
L
E
F
D
-----------
M
I
----------
G
----
M
D
F
F
--------
Y
A
D
-----------------
Q
G
V
Q
C
P
---------------
S
D
D
E
V
A
R
A
I
L
G
L
A
D
H
G
Y
L
D
R
I
L
L
S
H
D
--
V
F
V
K
M
M
L
T
R
Y
-----
G
------
G
N
------
G
Y
A
F
V
T
K
H
F
L
P
R
L
R
R
H
G
L
D
D
A
A
L
E
T
L
M
V
T
N
P
-------
9
PsiBlast_PDB
91.05
29%
-62
- C3 -
1I0B
12
OPD_BREDI
A:
[3-326]
---
R
I
N
T
V
R
G
P
I
T
I
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
R
A
R
A
A
G
V
R
T
I
V
D
V
S
T
F
D
I
G
R
D
V
S
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
----
L
W
F
DP-
P
L
S
M
R
L
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
Y
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
A
A
-
S
Q
-
R
D-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
A
-
L
A
A
R
G
Y
L
I
G
L
D
-------------------------------
H
--------
I
P
H
-----------------
S
AIGLEDN
A
S
A
S
A
L
LGIRS
W
Q
T
R
A
L
L
I
K
A
L
I
---
D
Q
G
Y
M
K
Q
I
L
V
S
N
D
WL
F
G
F
S
S
Y
V
T
N
I
-----
M
D
V
M
D
R
V
N
P
D
-----
G
M
A
F
I
P
L
R
V
I
P
F
L
R
E
K
G
V
P
Q
E
T
L
A
G
I
T
V
T
N
P
A
R
F
L
S
--
28
PsiBlast_CBE
90.80
32%
-68
- C3 -
1BF6
3
PHP_ECOLI
B:
[1-290]
------------
S
F
D
P
T
G
Y
T
L
A
H
E
H
-
L
------
H
I
D
L
S
G
-------------------
F
K
N
--
N
------------------------------
V
D
C
------
R
L
D
Q
Y
A
F
I
C
Q
E
-----
M
N
D
L
M
T
R
G
V
R
N
V
I
E
M
T
N
R
Y
M
G
R
N
A
Q
F
M
L
D
V
M
R
E
T
G
I
-----
N
V
V
A
C
T
G
Y
Y
Q
D
A
F
F
---
P
E
H
V
A
T
R
S
V
Q
E
L
A
Q
E
M
V
D
E
I
E
Q
G
I
D
----------
G
T
E
L
K
A
G
I
I
A
E
I
G
T
S
E
G
-
K
I
T
P
L
E
E
K
V
F
I
A
A
A
L
A
H
N
Q
T
G
R
P
I
S
T
H
T
S
F
-
S
T
-
M
--
G
L
E
Q
L
A
L
L
Q
A
H
G
V
D
L
S
R
V
T
V
G
H
C
D
-
L
K
-
D
N
L
D
N
I
L
K
-
M
I
D
L
G
A
Y
V
Q
F
D
-----------
T
I
----------
G
----
K
N
S
Y
--------
Y
P
D
-----------------
E
--------------------
K
R
I
A
M
L
H
A
L
R
---
D
R
G
L
L
N
R
V
M
L
S
M
D
--
I
T
R
R
S
H
L
K
A
------
N
------
G
G
Y
-----
G
Y
D
Y
L
L
T
T
F
I
P
Q
L
R
Q
S
G
F
S
Q
A
D
V
D
V
M
L
R
E
N
P
S
Q
F
F
---
6
PsiBlast_PDB
90.77
29%
-60
- C3 -
1PSC
4
OPD_BREDI
A:
[36-359]
---
R
I
N
T
V
R
G
P
I
T
I
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
R
A
R
A
A
G
V
R
T
I
V
D
V
S
T
F
D
I
G
R
D
V
S
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
----
L
W
F
DP-
P
L
S
M
R
L
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
Y
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
A
A
-
S
Q
-
R
D
-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
A
-
L
A
A
R
G
Y
L
I
G
L
D
-------------------------------
H
--------
I
P
H
-----------------
S
AIGLEDN
A
S
A
S
A
L
LGIRS
W
Q
T
R
A
L
L
I
K
A
L
I
---
D
Q
G
Y
M
K
Q
I
L
V
S
N
D
WL
F
G
F
S
S
Y
V
T
N
I
-----
M
D
V
M
D
R
V
N
P
D
-----
G
M
A
F
I
P
L
R
V
I
P
F
L
R
E
K
G
V
P
Q
E
T
L
A
G
I
T
V
T
N
P
A
R
F
L
S
--
15
PsiBlast_PDB
90.55
29%
-66
- C3 -
4E3T
2
OPD_BREDI
A:
[4-327]
---
R
I
N
T
V
R
G
P
I
T
I
S
E
V
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
PEFFGS
R
E
A
L
V
E
K
A
V
R
G
-----
L
R
R
A
R
A
A
G
V
R
T
I
V
D
V
S
T
F
D
L
G
R
D
V
R
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
V
--
W
L
D
P
---
P
L
S
I
R
M
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
Y
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
--
A
I
T
G
-
K
V
T
P
F
Q
E
L
V
L
R
A
A
A
R
A
S
L
A
T
G
V
P
V
I
T
H
T
-
A
-
G
S
-
Q
RG
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
E
T
-
D
D
L
S
Y
L
T
A
-
L
A
A
R
G
Y
L
I
G
L
D
-----------
R
I
PHSAIGLEDN
A
----
S
A
T
A
--------
F
M
G
-----------------
S
RS
W
Q
----------------
T
R
A
L
L
I
K
A
L
I
---
D
Q
G
Y
M
K
Q
I
L
V
S
N
D
WL
F
G
I
S
S
Y
V
T
N
F
M
D
V
M
D
S
------
V
N
P
D----
G
M
A
F
I
P
L
R
V
I
P
F
L
R
E
K
G
I
P
Q
E
T
L
A
G
I
T
V
T
N
P
A
R
F
L
S
--
11
PsiBlast_PDB
90.43
29%
-65
- C3 -
1PTA
-
OPD_BREDI
A:
[36-359]
---
R
I
N
T
V
R
G
P
I
T
I
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
R
A
R
A
A
G
V
R
T
I
V
D
V
S
T
F
D
I
G
R
D
V
S
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
----
L
W
F
DP-
P
L
S
M
R
L
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
Y
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
A
A
-
S
Q
-
R
D
-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
A
-
L
A
A
R
G
Y
L
I
G
L
D
-------------------------------
H
--------
I
P
H
-----------------
S
AIALLGIRS
W
Q
---------
T
R
A
L
L
I
K
A
L
I
---
D
Q
G
Y
M
K
Q
I
L
V
S
N
D
W
L
F
G
F
S
S
Y
V
T
N
I
-----
M
DVMDRV
N
P
D
-----
G
M
A
F
I
P
L
R
V
I
P
F
L
R
E
K
G
V
P
Q
E
T
L
A
G
I
T
V
T
N
P
A
R
F
L
S
--
12
PsiBlast_PDB
90.32
29%
-62
- C3 -
2D2G
4
?
A:
[5-327]
----
I
N
T
V
R
G
P
I
P
V
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
H
A
R
A
A
G
V
Q
T
I
V
D
V
S
T
F
D
I
G
R
D
V
R
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
----
L
W
F
DP-
P
L
S
M
R
M
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
H
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
S
A
-
S
Q
-
R
D-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
G
-
L
A
A
R
G
Y
L
V
G
L
D
RMPYSAIGLEG
N
A
----------
S
----
A
L
A
L
--------
F
G
T
RS
W
--------------
Q
--------------------
T
R
A
L
L
I
K
A
L
I
---
D
R
G
Y
K
D
R
I
L
V
S
H
D
WL
F
G
F
S
S
Y
V
T
N
I
-----
M
D
V
M
D
R
I
N
P
D
-----
G
M
A
F
V
P
L
R
V
I
P
F
L
R
E
K
G
V
P
P
E
T
L
A
G
V
T
V
A
N
P
A
R
F
L
S
--
14
PsiBlast_PDB
90.24
29%
-61
- C3 -
2D2J
5
?
A:
[5-327]
----
I
N
T
V
R
G
P
I
P
V
S
E
A
G
F
T
L
T
H
E
H
-
I
--------
C
G
S
S
-------------------
A
G
F
--
L
------------------------------
R
A
W
P-----
E
F
F
G
S
R
K
A
L
A
E
K
A
V
R
G
L
R
H
A
R
A
A
G
V
Q
T
I
V
D
V
S
T
F
D
I
G
R
D
V
R
L
L
A
E
V
S
R
A
A
D
V
-----
H
I
V
A
A
T
G
----
L
W
F
DP-
P
L
S
M
R
M
R
S
V
E
E
L
T
Q
F
F
L
R
E
I
Q
H
G
I
E
----------
D
T
G
I
R
A
G
I
I
K
V
-
A
T
-
T
G
-
K
A
T
P
F
Q
E
L
V
L
K
A
A
A
R
A
S
L
A
T
G
V
P
V
T
T
H
T
S
A
-
S
Q
-
R
D-
G
E
Q
Q
A
A
I
F
E
S
E
G
L
S
P
S
R
V
C
I
G
H
S
D
-
D
T
-
D
D
L
S
Y
L
T
G
-
L
A
A
R
G
Y
L
V
G
L
D
RMPYSAIGLEG
N
A
----------
S
----
A
L
A
L
--------
F
G
T
RS
W
--------------
Q
--------------------
T
R
A
L
L
I
K
A
L
I
---
D
R
G
Y
K
D
R
I
L
V
S
H
D
WL
F
G
F
S
S
Y
V
T
N
I
-----
M
D
V
M
D
R
I
N
P
D
-----
G
M
A
F
V
P
L
R
V
I
P
F
L
R
E
K
G
V
P
P
E
T
L
A
G
V
T
V
A
N
P
A
R
F
L
S
--