@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1975: (2016-03-30 )
MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAMPTRQAAKLCPNGIFIHGNMAHYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMKSATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKKPAGITVVTPEEAEAFLEQIPVTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPHRDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTITKRLTLNEYTNDASQIYQAAALLLIESYTGQDSIRLIGLTVTNLKPVYFENLRLEGL
Atome Classification :
(84 SA)
----------------------------------------------------------------.........10........20........30...---.....40........50........60........70........80........90........100.......110......-.120------------------.........130.......140.......150.......160.......--170.......180.......190.......200....--...210......--.220.......230.......240.......250.......260.......270.......280-----........290.......300.......310.......320......----.330--.........340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------MDTSR
K
I
I
H
I
D
M
D
A
F
Y
A
S
V
EQRDHPEFRG
K
P
L
I
I---GGDPNK
R
G
V
V
A
T
CS
Y
E
A
R
KFGVHSAM
P
T
R
Q
A
A
K
LCP
N
G
I
F
IHGN
M
A
H
Y
V
E
V
S
N
Q
I
R
E
I
F
S
R
Y
T
D
I
IEPLSL
D
E
A
Y
L
D
VTENKKG-
M
K
--------------------
S
A
T
M
V
A
R
E
I
Q
Q
T
I
Y
Q
E
LGLTASAGV
S
F
N
K
F
I
A
K
I
A
S
D
FKKPA
G
I
T
V
V
T
P
--
E
E
A
E
A
F
L
E
QIPV
T
K
F
YGV
G
K
V
T
A
E
K
L
H
R
LGIETGADL--KKW
S
E
W
D
L
I
R
E
L
--
H
KH
G
Y
H
L
Y
R
H
VRGRSNNIVNP
H
R
D
R
K
SVGKE
T
T
F
E
F
NV
L
D
S
R
V
L
E
Q
S
L
M
Q
F
A
K
K
V
E
E
R
L
I
K
L
Q
------KHG
K
T
V
V
L
K
L
RYSD
F
T
T
I
T
K
R
L
T
LNEYT
N
D
A
S
Q
I
Y
Q
A
A
A
L
L
L
I
ESYT----GQ----D
S
I
R
L
I
G
L
T
VTNLK
P
V
Y
F
E
N
L
RLEGL
8
PsiBlast_PDB
94.48
45%
-92
- C3 -
4Q44
7
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
9
PsiBlast_PDB
94.41
45%
-91
- C3 -
4Q45
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
26
PsiBlast_CBE
94.32
45%
-93
- C3 -
4IRK
4
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
25
PsiBlast_CBE
93.69
45%
-91
- C3 -
4Q44
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
29
PsiBlast_CBE
93.67
45%
-96
- C3 -
4R8U
4
?
B:
[1-336]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
---------------
7
PsiBlast_PDB
93.60
45%
-91
- C3 -
4IRK
6
DPO4_ECOLI
B:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
4
PsiBlast_PDB
93.60
45%
-93
- C3 -
4R8U
4
DPO4_ECOLI
A:
[1-339]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
-------------
21
PsiBlast_CBE
93.58
45%
-86
- C3 -
4Q43
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
27
PsiBlast_CBE
93.45
45%
-92
- C3 -
4IRD
7
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
3
PsiBlast_PDB
93.29
45%
-90
- C3 -
4Q43
7
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
28
PsiBlast_CBE
93.20
45%
-90
- C3 -
4IRC
7
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
5
PsiBlast_PDB
93.15
45%
-87
- C3 -
4IRC
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
22
PsiBlast_CBE
93.05
45%
-92
- C3 -
4IR9
7
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
24
PsiBlast_CBE
92.98
45%
-90
- C3 -
4Q45
7
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
1
PsiBlast_PDB
92.98
45%
-89
- C3 -
4IR1
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
23
PsiBlast_CBE
92.70
45%
-90
- C3 -
4IR1
7
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
6
PsiBlast_PDB
92.57
45%
-87
- C3 -
4IRD
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
A
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
2
PsiBlast_PDB
92.54
45%
-89
- C3 -
4IR9
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
-
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
--
Q
K
C
D
L
V
M
L
L
K
R
F
--
G
K
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PDLLIA
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
L
-
N
K
A
D
L
I
--
A
T
A
R
K
T
W
D
E
R
R
----
G
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------
102
Fugue
83.96
32%
-85
- C3 -
2OH2
4
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
---
G
S
----
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
-
R
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
G
T-
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
--
Y
Q
Q
R
A
L
L
S
L
L
F
S
--
E
T
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
I
-
N
K
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
R
------
L
K
G
R
T
V
T
I
K
L
K
N
V
N
F
E
V
K
T
R
A
S
T
V
S
S
V
V
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
----
A
D
FPHP
L
R
L
R
L
M
G
V
R
I
S
S
F
P
------------
104
Fugue
82.66
32%
-84
- C3 -
2W7O
5
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
---
G
S
----
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
-
R
Q
NWPEDKRRYFIKQN
S
V
V
F
G
T
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
--
Y
Q
Q
R
A
L
L
S
L
L
F
S
--
E
T
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
I
-
N
K
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
R
------
L
K
G
R
T
V
T
I
K
L
K
N
V
N
F
E
V
K
T
R
A
S
T
V
S
S
V
V
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
ADFP
H
P
----
L
R
L
R
L
M
G
V
R
I
S
S
F
P
N
E
----------
13
PsiBlast_PDB
79.44
34%
-97
- C3 -
4QWB
13
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
A
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
98
PsiBlast_CBE
79.03
34%
-96
- C3 -
1RYS
7
DPO4_SULSO
B:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
18
PsiBlast_PDB
78.94
34%
-97
- C3 -
4QWA
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
85
PsiBlast_CBE
78.87
34%
-99
- C3 -
1S9F
5
DPO4_SULSO
C:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
72
PsiBlast_CBE
78.87
34%
-95
- C3 -
2IBK
8
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
91
PsiBlast_CBE
78.75
34%
-94
- C3 -
1S97
4
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
33
PsiBlast_CBE
78.68
34%
-93
- C3 -
4TQS
6
?
B:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
70
PsiBlast_CBE
78.55
34%
-93
- C3 -
2J6T
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
94
PsiBlast_CBE
78.53
34%
-95
- C3 -
1S0O
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
19
PsiBlast_PDB
78.48
34%
-94
- C3 -
4QWD
7
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
73
PsiBlast_CBE
78.47
34%
-94
- C3 -
2IA6
8
DPO4_SULSO
B:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
96
PsiBlast_CBE
78.36
34%
-96
* C3 *
1S0M
8
DPO4_SULSO
B:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
50
PsiBlast_CBE
78.36
34%
-95
- C3 -
2W9A
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
35
PsiBlast_CBE
78.36
34%
-96
- C3 -
4RZR
8
?
D:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
17
PsiBlast_PDB
78.34
34%
-95
- C3 -
4QW9
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
36
PsiBlast_CBE
78.32
34%
-97
- C3 -
4RZR
5
?
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
37
PsiBlast_CBE
78.26
34%
-94
- C3 -
4GC7
6
?
B:
[10-286]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
93
PsiBlast_CBE
78.24
34%
-97
- C3 -
1S0O
8
DPO4_SULSO
B:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
88
PsiBlast_CBE
78.22
34%
-89
- C3 -
1S97
4
DPO4_SULSO
D:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
74
PsiBlast_CBE
78.22
34%
-98
- C3 -
2IA6
8
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
81
PsiBlast_CBE
78.16
34%
-94
- C3 -
2BQU
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
100
PsiBlast_CBE
78.10
34%
-96
- C3 -
1RYR
5
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
92
PsiBlast_CBE
78.10
34%
-94
- C3 -
1S10
5
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
16
PsiBlast_PDB
78.06
34%
-100
- C3 -
4QW8
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
62
PsiBlast_CBE
77.99
34%
-94
- C3 -
2R8I
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
78
PsiBlast_CBE
77.97
34%
-95
- C3 -
2C28
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
80
PsiBlast_CBE
77.94
34%
-93
- C3 -
2BR0
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
99
PsiBlast_CBE
77.90
34%
-95
- C3 -
1RYS
5
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
58
PsiBlast_CBE
77.90
34%
-93
- C3 -
2V4R
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
67
PsiBlast_CBE
77.84
34%
-93
- C3 -
2JEG
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
89
PsiBlast_CBE
77.76
34%
-92
- C3 -
1S97
4
DPO4_SULSO
C:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
84
PsiBlast_CBE
77.70
34%
-97
- C3 -
1S9F
5
DPO4_SULSO
D:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
69
PsiBlast_CBE
77.69
34%
-93
- C3 -
2J6U
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
97
PsiBlast_CBE
77.66
34%
-97
- C3 -
1S0M
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
61
PsiBlast_CBE
77.56
34%
-96
- C3 -
2RDJ
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
87
PsiBlast_CBE
77.47
34%
-94
- C3 -
1S9F
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
39
PsiBlast_CBE
77.46
34%
-97
- C3 -
4GC6
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
82
PsiBlast_CBE
77.36
34%
-95
- C3 -
2BQR
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
64
PsiBlast_CBE
77.35
34%
-92
- C3 -
2R8G
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
20
PsiBlast_PDB
77.32
34%
-96
- C3 -
4QWE
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
95
PsiBlast_CBE
77.29
34%
-93
- C3 -
1S0N
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
79
PsiBlast_CBE
77.25
34%
-91
- C3 -
2C22
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
54
PsiBlast_CBE
77.24
34%
-90
- C3 -
2VA2
5
DPO4_SULSO
B:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
77
PsiBlast_CBE
77.17
34%
-95
- C3 -
2C2D
7
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
59
PsiBlast_CBE
77.17
34%
-93
- C3 -
2V4Q
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
76
PsiBlast_CBE
76.97
34%
-93
- C3 -
2C2E
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
90
PsiBlast_CBE
76.96
34%
-98
- C3 -
1S97
4
DPO4_SULSO
B:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
63
PsiBlast_CBE
76.87
34%
-96
- C3 -
2R8H
6
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
34
PsiBlast_CBE
76.82
34%
-96
- C3 -
4TQS
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
45
PsiBlast_CBE
76.64
34%
-93
- C3 -
2XCP
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
75
PsiBlast_CBE
76.55
34%
-92
- C3 -
2C2R
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
43
PsiBlast_CBE
76.50
34%
-98
- C3 -
3FDS
16
DPO4_SULSO
A:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
38
PsiBlast_CBE
76.49
34%
-93
- C3 -
4GC7
7
DPO4_SULSO
A:
[10-286]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
55
PsiBlast_CBE
76.40
34%
-93
- C3 -
2VA2
5
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
42
PsiBlast_CBE
76.35
34%
-92
- C3 -
3M9M
8
DPO4_SULSO
B:
[3-279]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
51
PsiBlast_CBE
76.25
34%
-90
- C3 -
2W8L
6
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
56
PsiBlast_CBE
76.15
34%
-92
- C3 -
2V9W
6
DPO4_SULSO
B:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
44
PsiBlast_CBE
75.97
34%
-94
- C3 -
2XCP
5
DPO4_SULSO
B:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
48
PsiBlast_CBE
75.96
34%
-90
- C3 -
2W9C
6
DPO4_SULSO
B:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
57
PsiBlast_CBE
75.91
34%
-87
- C3 -
2V9W
5
DPO4_SULSO
A:
[9-285]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
--
L
S
I
-
E
F
D
K
L
K
G
M
IG
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
31
PsiBlast_CBE
75.10
35%
-86
- C3 -
4F4W
5
DPO4_SULAC (first)
B:
[3-280]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
K
P
L
V
V
CVY
S
G
R
T
K
T
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
N
K
V
E
G
N
F
E
--------------------
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
R
P
--
T
E
V
Q
D
F
L
N
E
L
D
I
D
E
I
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
LS
K
N
Y
N
E
L
E
K
I
T
G
K
--
A
K
A
L
Y
-
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
12
PsiBlast_PDB
75.00
35%
-92
- C3 -
4F4X
5
DPO4_SULAC (first)
A:
[3-280]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
K
P
L
V
V
C
VY
S
G
R
T
K
T
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
N
K
V
E
G
N
F
E
--------------------
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
R
P
--
T
E
V
Q
D
F
L
N
E
L
D
I
D
E
I
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
L
S
K
N
Y
N
E
L
E
K
I
T
G
K
--
A
K
A
L
Y
-
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
---
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
------
K
R
---------------------------------------------------------------------------------
11
PsiBlast_PDB
74.25
35%
-95
- C3 -
4F4Y
5
DPO4_SULAC (first)
A:
[3-262]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
K
P
L
V
V
C
V
Y
S
G
R
T
K
T
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
N
K
V
E
G
N
F
E
--------------------
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
R
P
--
T
E
V
Q
D
F
L
N
E
L
D
I
D
E
I
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
LS
K
N
Y
N
E
L
E
K
I
T
G
K
--
A
K
A
L
Y
-
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
Y
L
T
L
P
Y
N
T
R
D
V
K
V
I
------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.60
35%
-93
- C3 -
4F4Y
5
DPO4_SULAC (first)
B:
[3-262]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
K
P
L
V
V
CVY
S
G
R
T
K
T
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
N
K
V
E
G
N
F
E
--------------------
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
R
P
--
T
E
V
Q
D
F
L
N
E
L
D
I
D
E
I
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
LS
K
N
Y
N
E
L
E
K
I
T
G
K
--
A
K
A
L
Y
-
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
Y
L
T
L
P
Y
N
T
R
D
V
K
V
I
------------------------------------------------------------------------------------------------------------