@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1984: (2016-03-30 )
VIDTTKTNEKATKKQNKSGAELLIDALKKQQVDMIFGYPGGAVLPLYDAFYDCDIPHILTRHEQGAIHAAEGYARVTGKPGVVVVTSGPGATNVLTGIADAMSDSIPLVIFTGQVHTPGIGKDAFQEADMIGLTIPITKYNYQVRDVRDLPKIVNEAFHIASTGRKGPVVVDIPKDMGIIQTESVRPDTIDLPGYQPTYSPNPLQLEKLMQSLSAASKPLILAGAGVNHARATAELLEFAERYQIPIVNTLLGLGSFPQSHDLFLGMGGMHGSYAANMALTDCDLLINFGSRFDDRLASAPKEFATKATIAHIDIDPAEIGKIIETQIPIVADINETLTQLLQMELPVHPDTSHWYKLNMTRKNRHPFNFDRTKKAEIKPQRVIELIGEITQGEALVSTDVGQHQMWAAQFYPFQFDHQIITSGGLGTMGFGFPAAVGAQLAFPDKTVVAIVGDGGFQMTNQELAILNDYQINVKTVIINNGSLGMVRQWQEKFHGERYSHSIFTSQPDFVKLSEAYGVKGVRLTNPETLEKDLRKAFAHPGPIVIDVHVAKDELVLPMVPSGKPNHQMEGVE
Atome Classification :
(20 SA)
.........10........20........30........40........50-.-..-.....60........70......-..80........90........100.......110.......120.......130.......140.......150.......160.......170.......180........190........200.--......210.....-------..220.....-..230........240.......250.......260.......270-...-....280.......290.......300....---------...310.......320.......330.......340.......-----350.......360-...--...--.370..-......380.......390-...---......400.......410.......420.......430.......440.......450.......460.......470.......480.......490......--------.500-.....---------...510.......520.......530--.......----540.......550.......560.......570.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VIDTTKTN
E
K
A
T
K
KQNKS
G
A
E
L
L
I
D
A
L
K
KQQV
D
M
I
FGYPGGA
V
L
P
L
Y
D
A
F
Y-D-CD-I
P
H
I
L
T
RHEQG
A
I
HAAE
G
Y
A
R
VT-GKP
G
V
V
V
V
TSGPG
A
T
N
V
L
T
G
I
A
D
A
MSDSI
P
L
V
I
F
TGQVHTPGIG
K
D
A
F
QEAD
M
I
G
L
T
I
P
I
T
KY
N
Y
Q
V
R
D
V
R
D
L
P
K
I
V
N
E
A
F
HIASTGRKG
P
V
V
V
DIPKDMG
I
I
Q
-TESVRPDTID-LPGYQPTYSP
N
P
--
L
Q
L
E
K
L
M
Q
S
L
S
AAS-------K
P
L
I
L
AGAGV-N
H
A
-
R
A
T
A
E
L
L
E
F
A
E
R
YQI
P
I
V
N
T
L
L
GLGSFPQSH
D
L
F
L
GMGGMHG-SYA-ANMALT
D
C
D
L
L
I
N
F
G
S
R
F
D
D
R
L
ASA
P
K
E
F
AT---------K
A
T
I
A
H
I
DI
D
P
A
E
I
G
K
I
I
ETQI
P
I
V
AD
I
N
E
T
L
T
Q
L
L
Q
M
ELPVH-----PDTS
H
W
Y
K
L
NMTR-KNR--HPF--NF-DRT-KKAEI
K
P
Q
R
V
I
E
L
I
G
E
I---TQG---
E
A
L
V
STDVGQ
H
Q
M
W
A
A
QFYP
F
Q
FD
H
Q
I
ITSGGLGTMGFG
F
P
A
AVGAQLAFPD
K
T
V
V
A
I
VGDGG
F
Q
M
TNQ
E
L
A
I
L
N
D
Y
Q
I
N
V
K
T
V
I
INNGS
L
G
M
V
R
Q
W
Q
E
K
FHGER--------YSH--SIFTS---------QP
D
F
V
K
L
S
E
AYGVK
G
V
RLT
N
P
E
T
L
E
K
--
D
L
R
K
AFA----HPG
P
I
V
I
D
V
H
VAKD
E
L
V
L
P
MVPSGKPNHQMEGVE
27
PsiBlast_CBE
98.73
44%
-93
- C4 -
1N0H
9
ILVB_YEAST
B:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
S
-------
S
R
--
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
25
PsiBlast_CBE
98.73
44%
-93
- C4 -
1T9B
9
ILVB_YEAST
B:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
S
--------
R
--
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
5
PsiBlast_PDB
98.31
44%
-93
- C4 -
1T9C
7
ILVB_YEAST
A:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
S
-------
S
R
--
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
3
PsiBlast_PDB
98.15
44%
-91
- C4 -
1T9A
9
ILVB_YEAST
A:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
-------
T
S
R
--
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
26
PsiBlast_CBE
97.90
44%
-93
- C4 -
1T9A
9
ILVB_YEAST
B:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
-------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
24
PsiBlast_CBE
97.87
44%
-95
- C4 -
1T9C
7
ILVB_YEAST
B:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
-------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
21
PsiBlast_CBE
97.85
44%
-93
- C4 -
1T9D
10
ILVB_YEAST
D:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
S
-------
S
R
--
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
DLINLAK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
EARRAAAEG
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
AND
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
6
PsiBlast_PDB
97.41
44%
-93
- C4 -
1T9D
9
ILVB_YEAST
A:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
-------
T
S
R
--
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
2
PsiBlast_PDB
97.17
44%
-93
- C4 -
1N0H
9
ILVB_YEAST
A:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
S
------
T
S
R
--
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
29
HHSearch
97.00
43%
-87
- C4 -
1T9B
9
ILVB_YEAST
A:
[75-655]
---------
M
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
-
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
---------------
F
V
M
--
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
-------
K
P
V
L
Y
V
G
A
G
I
-
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
---
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
-
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
---
23
PsiBlast_CBE
96.40
44%
-96
- C4 -
1T9D
9
ILVB_YEAST
B:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
-----------------------
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
4
PsiBlast_PDB
95.97
44%
-96
- C4 -
1T9B
9
ILVB_YEAST
A:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
-----------------------
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
22
PsiBlast_CBE
95.50
44%
-93
- C4 -
1T9D
9
ILVB_YEAST
C:
[83-648]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
---------------------------
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
----------
1
PsiBlast_PDB
94.57
44%
-97
- C4 -
1JSC
8
ILVB_YEAST
A:
[36-591]
-----------------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
-
L
R
N
P
I
P
T
K
T
T
-
L
P
S
-----------
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
AK
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
-
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
Q
I
N
K
W
-
K
K
E
--
Y
P
Y
--
A
Y
M
E
E
T
-
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
------------------------
S
H
--
T
-
H
Q
L
---------
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
--
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
--------------------
30
HHSearch
90.38
33%
-84
* C4 *
2PAN
5
GCL_ECOLI
A:
[25-584]
--------------
A
K
M
R
A
V
D
A
A
M
Y
V
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
-
K
H
G
G
-
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
L
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
D
P
D
M
Y
E
-
P
-
L
P
V
Y
--
K
P
A
A
S
R
--
M
Q
I
E
K
A
V
E
M
L
I
Q
A
E
-------
R
P
V
I
V
A
G
G
G
V
-
I
N
A
-
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
H
E
L
M
A
G
M
V
G
L
Q
T
A
H
R
Y
-
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
R
K
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
GRL
P
C
R
K
E
W
V
A
D
C
Q
Q
R
-
K
R
T
--
L
L
R
--
K
---
T
H
F
D
N
V
P
V
K
P
Q
R
V
Y
E
E
M
N
K
A
---
F
G
R
---
D
V
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
D
M
D
Y
CVQLAFEN
I
N
S
SE
V
N
G
-
Y
---------
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
--
A
F
E
Q
A
K
A
L
M
A
Q
Y
R
V
P
V
V
V
E
V
I
L
E
R
V
T
N
I
-----------------
7
PsiBlast_PDB
90.30
33%
-92
- C4 -
2PAN
5
GCL_ECOLI
A:
[37-576]
--------------------------
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
-
K
H
G
G
-
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
L
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
-
I
E
-
F
D
P
D
M
Y
E
P
L
P
V
Y
K
P
A
A
S
R
M
----
Q
I
E
K
A
V
E
M
L
I
Q
A
E
-------
R
P
V
I
V
A
G
G
G
V
-
I
N
A
-
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
H
E
L
M
A
G
M
V
G
L
Q
T
-
A
H
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
R
K
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
GRL
P
C
R
K
E
W
V
A
D
C
Q
Q
R
-
K
R
T
L
L
R
K
T
--
H
F
-
D
N
V
-
P
---
V
K
P
Q
R
V
Y
E
E
M
N
K
A
---
F
G
R
---
D
V
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
D
M
D
Y
--------
C
V
Q
--
L
A
F
E
N
INSSEVNGY
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
--
A
F
E
Q
A
K
A
L
M
A
Q
Y
R
V
P
V
V
V
E
V
-------------------------
13
PsiBlast_PDB
88.71
29%
-86
- C4 -
4FEG
9
?
A:
[9-548]
--------------
T
N
I
L
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
-
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
-
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
-
I
P
A
-
E
D
W
Y
A
S
-
A
N
S
Y
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
-------
R
P
L
I
Y
Y
G
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
--
F
A
E
V
S
K
A
F
K
N
---------
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
--
V
S
E
-----
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
--
R
A
Y
L
A
S
L
-
E
D
K
-
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
---
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
--------
F
I
G
--
V
E
F
-
N
---------
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-------------------
15
PsiBlast_PDB
88.68
29%
-84
- C4 -
2EZ4
5
POXB_LACPL
A:
[9-548]
--------------
T
N
I
L
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
-
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
-
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
-
I
P
A
-
E
D
W
Y
A
S
-
A
N
S
Y
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
-------
R
P
L
I
Y
Y
G
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
--
F
A
E
V
S
K
A
F
K
N
---------
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
--
V
S
E
-----
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
--
R
A
Y
L
A
S
L
-
E
D
K
-
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
---
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
--------
F
I
G
--
V
E
F
-
N
---------
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-------------------
16
PsiBlast_PDB
88.58
29%
-86
- C4 -
2EZ8
4
POXB_LACPL
A:
[9-548]
--------------
T
N
I
L
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
-
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
-
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
-
I
P
A
-
E
D
W
Y
A
S
-
A
N
S
Y
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
-------
R
P
L
I
Y
Y
G
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
--
F
A
E
V
S
K
A
F
K
N
---------
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
--
V
S
E
-----
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
--
R
A
Y
L
A
S
L
-
E
D
K
-
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
---
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
--------
F
I
G
--
V
E
F
-
N
---------
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-------------------
19
PsiBlast_PDB
88.44
29%
-85
- C4 -
2EZU
4
POXB_LACPL
A:
[9-548]
--------------
T
N
I
L
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
-
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
-
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
-
I
P
A
-
E
D
W
Y
A
S
-
A
N
S
Y
Q
T
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
-------
R
P
L
I
Y
Y
G
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
--
F
A
E
V
S
K
A
F
K
N
---------
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
--
V
S
E
-----
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
--
R
A
Y
L
A
S
L
-
E
D
K
-
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
---
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
--------
F
I
G
--
V
E
F
-
N
---------
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-------------------