@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2006: (2016-03-31 )
MAKLEKDQEKVITQGKSGADLVVDSLINQGVTHVFGIPGAKIDKVFDVMEERGPELIVSRHEQNAAFMAAAIGRLTGKPGVVLVTSGPGASNLATGLVTATAEGDPVVAIAGNVTRQDRLKRTHQSMDNAALFRPITKYSEEVVHAESIPEAITNAFRSATEPNQGAAFVSLPQDIVNEPNVPVKAIRPLAKPENGPASKEQVAKLVTRLKKAKLPVLLLGMRASSPEVTGAIRRLLQKTSIPVVETFQAAGVISRDLEDNFFGRVGLFRNQPGDILLNKADLVITVGYDPIEYDPKAWNASGDRTIVHLDDIRADIDHYYQPVTELVGNIALTLDRVNAKFSGLELAEKELETLKELHAQLEERDVPPESDETNRVHPLSVIQTLRSAIDDNVTVTVDVGSHYIWMARHFRSYEPRRLLFSNGMQTLGVALPWGIAATLVHPGEKVVSISGDGGFLFSAMELETAVRLRAPLVHLVWNDGSYDMVAFQQKMKYGKEAAVRFGDVDIVKFAESFGAKGLRVTNPAELSDVLKEALETEGPVVVDIPIDYRDNIKLGETLLPDQFY
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340..-.....350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKL
E
K
D
Q
E
K
V
I
TQGKS
G
A
D
L
V
V
D
S
L
I
N
QG
V
T
H
V
FGIPG
A
K
I
D
K
V
F
D
V
M
E
ERGP
E
L
I
V
SRHEQ
N
A
A
F
M
A
A
A
I
G
RLTGKP
G
V
V
L
V
TSGPGA
S
N
LA
T
G
L
V
T
ATAEG
D
P
V
V
A
IAGNV
T
R
Q
D
R
L
K
R
T
H
QSMD
N
A
A
L
FR
P
I
T
K
Y
S
E
E
V
V
H
A
E
S
I
P
E
A
I
T
N
A
F
R
SATEPNQG
A
A
F
VSL
P
Q
D
I
VNEPNV
P
V
K
A
IRPLAKPENGPA
S
K
E
Q
V
A
K
L
V
T
R
L
K
KAKL
P
V
L
L
L
GMRASSP
E
V
T
G
A
I
R
R
L
L
Q
K
TSI
P
V
V
E
T
F
Q
A
AG
V
I
S
R
DLEDNFFGRVGLFRNQPG
D
I
L
L
NKA
D
L
V
I
T
VGYDPIEYDPKAWNASG
D
R
T
I
V
H
L
D
D
I
R
A
D
I
D
H
Y
Y
Q
P
V
T
E
L
V
G
N
I
A
L
T
L
D
RVNAKFSG-
L
E
L
A
E
K
E
L
E
T
L
K
E
L
H
A
Q
L
E
ERDVPPESDETNRV
H
P
L
S
V
I
Q
T
L
R
S
AIDDN
V
T
V
T
V
DVGS
H
Y
I
W
M
A
R
H
FRSYEP
R
R
L
L
F
SNG
M
Q
T
LGVAL
P
W
G
I
A
A
T
LVHPG
E
K
V
V
S
I
SGDG
G
F
L
F
S
A
M
E
L
E
T
A
V
RLRA
P
L
V
H
L
V
WNDGS
Y
D
M
V
A
F
Q
Q
K
M
KY
G
K
E
A
A
VRFGD
V
D
I
V
K
F
A
E
S
FGAKGLRVT
N
P
A
E
L
S
D
V
L
K
E
A
LETEG
P
V
V
V
D
IPIDYRDNIKLGETLLPDQFY
31
PsiBlast_CBE
98.21
62%
-89
- C6 -
4RJJ
16
?
H:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
37
PsiBlast_CBE
98.00
62%
-90
- C6 -
4RJJ
8
?
B:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
2
PsiBlast_PDB
98.00
62%
-91
- C6 -
4RJJ
7
?
A:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
36
PsiBlast_CBE
97.92
62%
-89
- C6 -
4RJJ
6
?
C:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
32
PsiBlast_CBE
97.82
62%
-89
- C6 -
4RJJ
16
?
G:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
3
PsiBlast_PDB
97.71
62%
-89
- C6 -
4RJK
9
?
A:
[15-562]
-------------
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
25
PsiBlast_CBE
97.70
62%
-91
- C6 -
4RJK
19
?
G:
[15-562]
-------------
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
23
PsiBlast_CBE
97.50
62%
-92
- C6 -
4RJI
4
?
B:
[15-562]
-------------
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
35
PsiBlast_CBE
97.44
62%
-89
- C6 -
4RJJ
3
?
D:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
21
PsiBlast_CBE
97.39
62%
-93
- C6 -
4RJI
3
?
D:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
1
PsiBlast_PDB
97.30
62%
-92
- C6 -
4RJI
3
?
A:
[15-560]
-------------
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
-------
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
---
24
PsiBlast_CBE
97.11
62%
-92
- C6 -
4RJK
19
?
H:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
--
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
29
PsiBlast_CBE
97.01
62%
-90
- C6 -
4RJK
4
?
C:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
22
PsiBlast_CBE
96.92
62%
-91
- C6 -
4RJI
4
?
C:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
28
PsiBlast_CBE
96.36
62%
-91
- C6 -
4RJK
2
?
D:
[14-562]
------------
K
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
---
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
30
PsiBlast_CBE
96.02
62%
-91
- C6 -
4RJK
10
?
B:
[15-562]
-------------
N
--
R
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
-
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
D
K
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
G
K
-
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
-
N
T
K
N
V
R
A
V
A
A
P
K
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
R
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
N
Q
P
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
D
P
I
E
Y
D
P
K
F
W
N
I
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-
V
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
P
A
D
W
K
S
D
R
A
H
P
L
E
I
V
K
E
L
R
N
A
V
D
D
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
Y
N
R
T
S
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
M
N
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
N
L
A
S
D
K
L
P
K
E
F
-
41
PsiBlast_CBE
88.90
49%
-91
- C6 -
1OZF
5
ILVB_KLEPN
B:
[5-546]
---------
Y
P
V
R
Q
W
A
H
G
A
D
L
V
V
S
Q
L
E
A
Q
G
V
R
Q
V
F
G
I
P
G
A
K
I
D
K
V
F
D
S
L
L
D
S
S
I
R
I
I
P
V
R
H
E
A
N
A
A
F
M
A
A
A
V
G
R
I
T
G
K
A
G
V
A
L
V
T
S
G
P
G
C
S
N
L
I
T
G
M
A
T
A
N
S
E
G
D
P
V
V
A
L
G
G
A
V
K
R
A
D
K
A
K
---
Q
S
M
D
T
V
A
M
F
S
P
V
T
K
Y
A
I
E
V
T
A
P
D
A
L
A
E
V
V
S
N
A
F
R
A
A
E
Q
G
R
P
G
S
A
F
V
S
L
P
Q
D
V
V
D
G
P
-
V
S
G
K
V
L
P
---
A
P
Q
M
G
A
A
P
D
D
A
I
D
Q
V
A
K
L
I
A
Q
A
K
N
P
I
F
L
L
G
L
M
A
S
Q
P
E
N
S
K
A
L
R
R
L
L
E
T
S
H
I
P
V
T
S
T
Y
Q
A
A
G
A
V
N
Q
D
N
F
S
R
F
A
G
R
V
G
L
F
N
N
Q
A
G
D
R
L
L
Q
L
A
D
L
V
I
C
I
G
Y
S
P
V
E
Y
E
P
A
M
W
N
-
S
G
N
A
T
L
V
H
I
D
V
L
P
A
Y
E
E
R
N
Y
T
P
D
V
E
L
V
G
D
I
A
G
T
L
N
K
L
A
Q
N
I
D
H
R
L
V
L
S
P
Q
A
A
E
I
L
R
D
R
Q
H
Q
R
E
L
L
D
R
--
A
Q
L
N
Q
F
A
L
H
P
L
R
I
V
R
A
M
Q
D
I
V
N
S
D
V
T
L
T
V
D
M
G
S
F
H
I
W
I
A
R
Y
L
Y
T
F
R
A
R
Q
V
M
I
S
N
G
Q
Q
T
M
G
V
A
L
P
W
A
I
G
A
W
L
V
N
P
E
R
K
V
V
S
V
S
G
D
G
G
F
L
Q
S
S
M
E
L
E
T
A
V
R
L
K
A
N
V
L
H
L
I
W
V
D
N
G
Y
N
M
V
A
I
Q
E
E
K
K
Y
Q
R
L
S
G
V
E
F
G
P
M
D
F
K
A
Y
A
E
S
F
G
A
K
G
F
A
V
E
S
A
E
A
L
E
P
T
L
R
A
A
M
D
V
D
G
P
A
V
V
A
I
P
V
D
Y
R
D
N
-------------
38
PsiBlast_CBE
88.87
49%
-93
- C6 -
1OZH
6
ILVB_KLEPN
C:
[7-546]
-----------
V
R
Q
W
A
H
G
A
D
L
V
V
S
Q
L
E
A
Q
G
V
R
Q
V
F
G
I
P
G
A
K
I
D
K
V
F
D
S
L
L
D
S
S
I
R
I
I
P
V
R
H
E
A
N
A
A
F
M
A
A
A
V
G
R
I
T
G
K
A
G
V
A
L
V
T
S
G
P
G
C
S
N
L
I
T
G
M
A
T
A
N
S
E
G
D
P
V
V
A
L
G
G
A
V
K
R
A
D
K
A
K
-----
M
D
T
V
A
M
F
S
P
V
T
K
Y
A
I
E
V
T
A
P
D
A
L
A
E
V
V
S
N
A
F
R
A
A
E
Q
G
R
P
G
S
A
F
V
S
L
P
Q
D
V
V
D
G
P
-
V
S
G
K
V
L
P
A
S
G
A
--
M
G
A
A
P
D
D
A
I
D
Q
V
A
K
L
I
A
Q
A
K
N
P
I
F
L
L
G
L
M
A
S
Q
P
E
N
S
K
A
L
R
R
L
L
E
T
S
H
I
P
V
T
S
T
Y
Q
A
A
G
A
V
N
Q
D
N
F
S
R
F
A
G
R
V
G
L
F
N
N
Q
A
G
D
R
L
L
Q
L
A
D
L
V
I
C
I
G
Y
S
P
V
E
Y
E
P
A
M
W
N
-
S
G
N
A
T
L
V
H
I
D
V
L
P
A
Y
E
E
R
N
Y
T
P
D
V
E
L
V
G
D
I
A
G
T
L
N
K
L
A
Q
N
I
D
H
R
L
V
L
S
P
Q
A
A
E
I
L
R
D
R
Q
H
Q
R
E
L
L
D
R
--
A
Q
L
N
Q
F
A
L
H
P
L
R
I
V
R
A
M
Q
D
I
V
N
S
D
V
T
L
T
V
D
M
G
S
F
H
I
W
I
A
R
Y
L
Y
T
F
R
A
R
Q
V
M
I
S
N
G
Q
Q
T
M
G
V
A
L
P
W
A
I
G
A
W
L
V
N
P
E
R
K
V
V
S
V
S
G
D
G
G
F
L
Q
S
S
M
E
L
E
T
A
V
R
L
K
A
N
V
L
H
L
I
W
V
D
N
G
Y
N
M
V
A
I
Q
E
E
K
K
Y
Q
R
L
S
G
V
E
F
G
P
M
D
F
K
A
Y
A
E
S
F
G
A
K
G
F
A
V
E
S
A
E
A
L
E
P
T
L
R
A
A
M
D
V
D
G
P
A
V
V
A
I
P
V
D
Y
R
D
N
-------------
39
PsiBlast_CBE
88.54
49%
-90
- C6 -
1OZH
6
ILVB_KLEPN
B:
[7-546]
-----------
V
R
Q
W
A
H
G
A
D
L
V
V
S
Q
L
E
A
Q
G
V
R
Q
V
F
G
I
P
G
A
K
I
D
K
V
F
D
S
L
L
D
S
S
I
R
I
I
P
V
R
H
E
A
N
A
A
F
M
A
A
A
V
G
R
I
T
G
K
A
G
V
A
L
V
T
S
G
P
G
C
S
N
L
I
T
G
M
A
T
A
N
S
E
G
D
P
V
V
A
L
G
G
A
V
K
R
A
D
-------
S
M
D
T
V
A
M
F
S
P
V
T
K
Y
A
I
E
V
T
A
P
D
A
L
A
E
V
V
S
N
A
F
R
A
A
E
Q
G
R
P
G
S
A
F
V
S
L
P
Q
D
V
V
D
G
P
-
V
S
G
K
V
L
P
A
S
G
A
P
Q
M
-
A
A
P
D
D
A
I
D
Q
V
A
K
L
I
A
Q
A
K
N
P
I
F
L
L
G
L
M
A
S
Q
P
E
N
S
K
A
L
R
R
L
L
E
T
S
H
I
P
V
T
S
T
Y
Q
A
A
G
A
V
N
Q
D
N
F
S
R
F
A
G
R
V
G
L
F
N
N
Q
A
G
D
R
L
L
Q
L
A
D
L
V
I
C
I
G
Y
S
P
V
E
Y
E
P
A
M
W
N
-
S
G
N
A
T
L
V
H
I
D
V
L
P
A
Y
E
E
R
N
Y
T
P
D
V
E
L
V
G
D
I
A
G
T
L
N
K
L
A
Q
N
I
D
H
R
L
V
L
S
P
Q
A
A
E
I
L
R
D
R
Q
H
Q
R
E
L
L
D
R
R
G
A
Q
L
N
Q
F
A
L
H
P
L
R
I
V
R
A
M
Q
D
I
V
N
S
D
V
T
L
T
V
D
M
G
S
F
H
I
W
I
A
R
Y
L
Y
T
F
R
A
R
Q
V
M
I
S
N
G
Q
Q
T
M
G
V
A
L
P
W
A
I
G
A
W
L
V
N
P
E
R
K
V
V
S
V
S
G
D
G
G
F
L
Q
S
S
M
E
L
E
T
A
V
R
L
K
A
N
V
L
H
L
I
W
V
D
N
G
Y
N
M
V
A
I
Q
E
E
K
K
Y
Q
R
L
S
G
V
E
F
G
P
M
D
F
K
A
Y
A
E
S
F
G
A
K
G
F
A
V
E
S
A
E
A
L
E
P
T
L
R
A
A
M
D
V
D
G
P
A
V
V
A
I
P
V
D
Y
R
D
N
-------------
40
PsiBlast_CBE
88.31
49%
-91
- C6 -
1OZG
5
ILVB_KLEPN
B:
[5-546]
---------
Y
P
V
R
Q
W
A
H
G
A
D
L
V
V
S
Q
L
E
A
Q
G
V
R
Q
V
F
G
I
P
G
A
K
I
D
K
V
F
D
S
L
L
D
S
S
I
R
I
I
P
V
R
H
E
A
N
A
A
F
M
A
A
A
V
G
R
I
T
G
K
A
G
V
A
L
V
T
S
G
P
G
C
S
N
L
I
T
G
M
A
T
A
N
S
E
G
D
P
V
V
A
L
G
G
A
V
K
R
A
D
K
A
K
---
Q
S
M
D
T
V
A
M
F
S
P
V
T
K
Y
A
I
E
V
T
A
P
D
A
L
A
E
V
V
S
N
A
F
R
A
A
E
Q
G
R
P
G
S
A
F
V
S
L
P
Q
D
V
V
D
G
P
-
V
S
G
K
V
L
P
A
S
-
A
P
Q
M
G
A
A
P
D
D
A
I
D
Q
V
A
K
L
I
A
Q
A
K
N
P
I
F
L
L
G
L
M
A
S
Q
P
E
N
S
K
A
L
R
R
L
L
E
T
S
H
I
P
V
T
S
T
Y
Q
A
A
G
A
V
N
Q
D
N
F
S
R
F
A
G
R
V
G
L
F
N
N
Q
A
G
D
R
L
L
Q
L
A
D
L
V
I
C
I
G
Y
S
P
V
E
Y
E
P
A
M
W
N
-
S
G
N
A
T
L
V
H
I
D
V
L
P
A
Y
E
E
R
N
Y
T
P
D
V
E
L
V
G
D
I
A
G
T
L
N
K
L
A
Q
N
I
D
H
R
L
V
L
S
P
Q
A
A
E
I
L
R
D
R
Q
H
Q
R
E
L
L
D
R
R
-
A
Q
L
N
Q
F
A
L
H
P
L
R
I
V
R
A
M
Q
D
I
V
N
S
D
V
T
L
T
V
D
M
G
S
F
H
I
W
I
A
R
Y
L
Y
T
F
R
A
R
Q
V
M
I
S
N
G
Q
Q
T
M
G
V
A
L
P
W
A
I
G
A
W
L
V
N
P
E
R
K
V
V
S
V
S
G
D
G
G
F
L
Q
S
S
M
E
L
E
T
A
V
R
L
K
A
N
V
L
H
L
I
W
V
D
N
G
Y
N
M
V
A
I
Q
E
E
K
K
Y
Q
R
L
S
G
V
E
F
G
P
M
D
F
K
A
Y
A
E
S
F
G
A
K
G
F
A
V
E
S
A
E
A
L
E
P
T
L
R
A
A
M
D
V
D
G
P
A
V
V
A
I
P
V
D
Y
R
D
N
-------------
5
PsiBlast_PDB
88.17
49%
-91
- C6 -
1OZF
10
ILVB_KLEPN
A:
[7-546]
-----------
V
R
Q
W
A
H
G
A
D
L
V
V
S
Q
L
E
A
Q
G
V
R
Q
V
F
G
I
P
G
A
K
I
D
K
V
F
D
S
L
L
D
S
S
I
R
I
I
P
V
R
H
E
A
N
A
A
F
M
A
A
A
V
G
R
I
T
G
K
A
G
V
A
L
V
T
S
G
P
G
C
S
N
L
I
T
G
M
A
T
A
N
S
E
G
D
P
V
V
A
L
G
G
A
V
K
R
A
D
K
A
K
Q
V
H
Q
S
M
D
T
V
A
M
F
S
P
V
T
K
Y
A
I
E
V
T
A
P
D
A
L
A
E
V
V
S
N
A
F
R
A
A
E
Q
G
R
P
G
S
A
F
V
S
L
P
Q
D
V
V
D
G
P
-
V
S
G
K
V
L
P
---
A
P
Q
M
G
A
A
P
D
D
A
I
D
Q
V
A
K
L
I
A
Q
A
K
N
P
I
F
L
L
G
L
M
A
S
Q
P
E
N
S
K
A
L
R
R
L
L
E
T
S
H
I
P
V
T
S
T
Y
Q
A
A
G
A
V
N
Q
D
N
F
S
R
F
A
G
R
V
G
L
F
N
N
Q
A
G
D
R
L
L
Q
L
A
D
L
V
I
C
I
G
Y
S
P
V
E
Y
E
P
A
M
W
N
-
S
G
N
A
T
L
V
H
I
D
V
L
P
A
Y
E
E
R
N
Y
T
P
D
V
E
L
V
G
D
I
A
G
T
L
N
K
L
A
Q
N
I
D
H
R
L
V
L
S
P
Q
A
A
E
I
L
R
D
R
Q
H
Q
R
E
L
L
D
R
R
G
A
Q
L
N
Q
F
A
L
H
P
L
R
I
V
R
A
M
Q
D
I
V
N
S
D
V
T
L
T
V
D
M
G
S
F
H
I
W
I
A
R
Y
L
Y
T
F
R
A
R
Q
V
M
I
S
N
G
Q
Q
T
M
G
V
A
L
P
W
A
I
G
A
W
L
V
N
P
E
R
K
V
V
S
V
S
G
D
G
G
F
L
Q
S
S
M
E
L
E
T
A
V
R
L
K
A
N
V
L
H
L
I
W
V
D
N
G
Y
N
M
V
A
I
Q
E
E
K
K
Y
Q
R
L
S
G
V
E
F
G
P
M
D
F
K
A
Y
A
E
S
F
G
A
K
G
F
A
V
E
S
A
E
A
L
E
P
T
L
R
A
A
M
D
V
D
G
P
A
V
V
A
I
P
V
D
Y
R
D
N
-------------
4
PsiBlast_PDB
88.15
49%
-89
- C6 -
1OZG
9
ILVB_KLEPN
A:
[6-546]
----------
P
V
R
Q
W
A
H
G
A
D
L
V
V
S
Q
L
E
A
Q
G
V
R
Q
V
F
G
I
P
G
A
K
I
D
K
V
F
D
S
L
L
D
S
S
I
R
I
I
P
V
R
H
E
A
N
A
A
F
M
A
A
A
V
G
R
I
T
G
K
A
G
V
A
L
V
T
S
G
P
G
C
S
N
L
I
T
G
M
A
T
A
N
S
E
G
D
P
V
V
A
L
G
G
A
V
K
R
A
D
K
A
K
Q
V
H
Q
S
M
D
T
V
A
M
F
S
P
V
T
K
Y
A
I
E
V
T
A
P
D
A
L
A
E
V
V
S
N
A
F
R
A
A
E
Q
G
R
P
G
S
A
F
V
S
L
P
Q
D
V
V
D
G
P
-
V
S
G
K
V
L
P
A
S
G
A
P
Q
M
G
A
A
P
D
D
A
I
D
Q
V
A
K
L
I
A
Q
A
K
N
P
I
F
L
L
G
L
M
A
S
Q
P
E
N
S
K
A
L
R
R
L
L
E
T
S
H
I
P
V
T
S
T
Y
Q
A
A
G
A
V
N
Q
D
N
F
S
R
F
A
G
R
V
G
L
F
N
N
Q
A
G
D
R
L
L
Q
L
A
D
L
V
I
C
I
G
Y
S
P
V
E
Y
E
P
A
M
W
N
-
S
G
N
A
T
L
V
H
I
D
V
L
P
A
Y
E
E
R
N
Y
T
P
D
V
E
L
V
G
D
I
A
G
T
L
N
K
L
A
Q
N
I
D
H
R
L
V
L
S
P
Q
A
A
E
I
L
R
D
R
Q
H
Q
R
E
L
L
D
R
R
G
A
Q
L
N
Q
F
A
L
H
P
L
R
I
V
R
A
M
Q
D
I
V
N
S
D
V
T
L
T
V
D
M
G
S
F
H
I
W
I
A
R
Y
L
Y
T
F
R
A
R
Q
V
M
I
S
N
G
Q
Q
T
M
G
V
A
L
P
W
A
I
G
A
W
L
V
N
P
E
R
K
V
V
S
V
S
G
D
G
G
F
L
Q
S
S
M
E
L
E
T
A
V
R
L
K
A
N
V
L
H
L
I
W
V
D
N
G
Y
N
M
V
A
I
Q
E
E
K
K
Y
Q
R
L
S
G
V
E
F
G
P
M
D
F
K
A
Y
A
E
S
F
G
A
K
G
F
A
V
E
S
A
E
A
L
E
P
T
L
R
A
A
M
D
V
D
G
P
A
V
V
A
I
P
V
D
Y
R
D
N
-------------