@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2059: (2016-03-31 )
LDKTKRKMIYETFMLILILLSLALLPYRNNFTFILNWIIWVIFTLDYLVRLYRADNKWHYVKTHPFQLIAIIPFYGGFRAARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFVLLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIVPVTPIGRILASIMMLFGIAFIGMITSTITNFFRAKKPTNSSTQRANKITQLISETPDLTKEEIAVVEQFLTLRKKELADENTKSDSE
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20.......---------.-----------------------------------30........40........50........60--..--......70.......-------------------.80......--..90..-----------------.---.....100--..---------......110.......120.---......130..------.-----.-----------------------------------------------...140.......150.......160.......170.......180.......190.......200.....---...210.......220.......230.......240.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LD
K
T
K
R
K
M
I
Y
E
T
F
M
L
I
L
I
L
L
S
L
A
LLPYR---------N-----------------------------------
N
F
T
F
I
L
N
W
I
I
W
V
I
F
T
L
D
Y
L
V
R
L
Y
RADN
K
W
H
Y
V
--
K
T--H
P
F
Q
L
I
A
I
IPFYG
G
F
-------------------
R
A
A
R
I
V
S
F
V
--
H
L
L
S
I
T
-----------------A---MG
R
R
Y
I
V
---
P
I
---------
Y
S
F
F
R
SNG
L
N
R
F
L
M
I
F
V
L
L
V
---
I
I
IPV
P
M
V
F
IE------P-----E-----------------------------------------------INNY
P
D
A
L
W
W
A
I
V
T
A
T
TVGYGD
I
V
PVT
P
I
G
R
I
L
A
S
I
M
M
L
F
G
I
A
F
I
G
M
I
T
S
T
I
T
N
F
F
RAKKPTNS
S
-
T
Q
R
A
N
---
K
I
T
Q
L
I
SETPDL
T
K
E
E
I
A
V
V
E
Q
F
L
T
L
R
K
K
E
LADENTKSDSE
1
PsiBlast_PDB
78.14
99%
-163
- C5 -
4H33
6
?
A:
[12-102]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
N
G
L
N
R
F
L
M
I
F
V
L
L
V
---
I
I
I
P
V
P
M
V
F
I
E
------
P
-----
E
-----------------------------------------------
I
N
N
Y
P
D
A
L
W
W
A
I
V
T
A
T
T
V
G
Y
G
D
I
V
P
V
T
P
I
G
R
I
L
A
S
I
M
M
L
F
G
I
A
F
I
G
M
I
T
S
T
I
T
N
F
F
R
C
K
K
P
T
-----------------------------------------------------
103
HHSearch
76.25
24%
-166
* C6 *
2R9R
13
KCNA2_RAT (first)
B:
[178-436]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
P
A
R
I
I
A
I
V
S
V
M
V
I
L
I
S
I
V
S
F
C
L
E
---------
T
LPIFRDENEDMHGGGVT
F
H
T
Y
S
Q
S
T
I
G
Y
Q
Q
S
TSFT
D
P
F
F
I
V
E
T
L
C
I
I
W
F
S
F
E
F
L
V
R
F
F
A
C
P
S
K
A
G
F
F
--
T
N
I
M
N
I
I
D
I
V
A
I
I
P
Y
Y
V
T
I
F
L
T
E
S
N
KS
V
L
Q
F
Q
N
V
R
R
V
V
Q
I
F
R
I
M
R
I
L
--
R
I
F
K
L
S
-----------------
R
HS
K
G
L
Q
I
L
G
Q
---
T
L
---------
K
A
S
--
M
R
E
L
G
L
L
I
F
F
L
F
I
G
V
---
I
L
F
S
S
A
V
Y
F
A
E
------
A
-----
D
ERDSQ------------------------------------------
F
P
S
I
P
D
A
F
W
W
A
V
V
S
M
T
T
V
G
Y
G
D
M
V
P
T
T
I
G
G
K
I
V
G
S
L
C
A
I
A
G
V
L
T
I
A
L
P
V
P
V
I
V
S
N
F
N
Y
F
Y
H
R
E
T
---------------------------------------------------
21
PsiBlast_CBE
75.22
99%
-166
- C5 -
4H37
4
?
B:
[14-99]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
L
N
R
F
L
M
I
F
V
L
L
V
---
I
I
I
P
V
P
M
V
F
I
E
------
P
-----
E
-----------------------------------------------
I
N
N
Y
P
D
A
L
W
W
A
I
V
T
A
T
T
V
G
Y
G
D
I
V
P
V
T
P
I
G
R
I
L
A
S
I
M
M
L
F
G
I
A
F
I
G
M
I
T
S
T
I
T
N
F
F
R
C
K
--------------------------------------------------------
2
PsiBlast_PDB
73.98
99%
-166
- C5 -
4H37
4
?
A:
[14-99]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
L
N
R
F
L
M
I
F
V
L
L
V
---
I
I
I
P
V
P
M
V
F
I
E
------
P
-----
E
-----------------------------------------------
I
N
N
Y
P
D
A
L
W
W
A
I
V
T
A
T
T
V
G
Y
G
D
I
V
P
V
T
P
I
G
R
I
L
A
S
I
M
M
L
F
G
I
A
F
I
G
M
I
T
S
T
I
T
N
F
F
R
C
K
--------------------------------------------------------
102
HHSearch
66.30
20%
-142
- C6 -
3BEH
7
CNGK1_RHILO
A:
[7-221]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
Y
A
P
L
N
A
V
L
A
A
P
G
L
L
A
V
A
A
L
T
IPDMS
G
R
S
R
-----------------------------------
L
A
L
A
A
L
L
A
V
I
W
G
A
Y
L
L
Q
L
A
A
T
L
L
K
R
R
A
G
V
V
R
D
--
R
T
P
K
I
A
I
D
V
L
A
V
L
V
P
L
A
A
F
L
LDGSPDW-----------
S
L
Y
C
A
V
W
L
L
--
K
P
L
R
D
S
-----------------
T
---
F
F
P
V
L
G
R
---
V
L
---------
A
N
E
--
A
R
N
L
I
G
V
T
T
L
F
G
V
V
L
---
F
A
V
A
L
A
A
Y
V
I
E
------
R
-----
D
IQPEK------------------------------------------
F
G
S
I
P
Q
A
M
W
W
A
V
V
T
L
S
T
T
G
Y
G
D
T
I
P
Q
S
F
A
G
R
V
L
A
G
A
V
M
M
S
G
I
G
I
F
G
L
W
A
G
I
L
A
T
G
F
Y
Q
E
V
R
R
G
----------------------------------------------------
3
PsiBlast_PDB
63.65
27%
-166
- C5 -
2A0L
4
KVAP_AERPE
A:
[54-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
D
L
I
L
V
I
I
L
W
A
D
Y
A
Y
R
A
Y
K
S
G
D
P
A
G
Y
V
--
K
K
--
T
L
Y
E
I
P
A
L
V
P
--------------------------
A
G
L
L
A
L
I
E
G
H
L
A
G
L
G
LFRL
V
R
L
L
R
F
L
R
I
L
L
I
I
S
---
R
G
S
K
F
L
S
---
A
I
ADAADK
I
R
F
Y
H
L
F
G
A
V
M
L
T
V
L
Y
G
A
F
A
I
Y
I
---
V
E
Y
P
D
P
----
N
------
S
-----
S
-----------------------------------------------
I
K
S
V
F
D
A
L
W
W
A
V
V
T
A
T
T
V
G
Y
G
D
V
V
P
A
T
P
I
G
K
V
I
G
I
A
V
M
L
T
G
I
S
A
L
T
L
L
I
G
T
V
S
N
M
F
Q
----------------------------------------------------------
101
HHSearch
63.28
28%
-166
- C5 -
1ORQ
7
KVAP_AERPE
C:
[7-222]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
L
V
E
L
G
V
S
Y
A
A
L
L
S
V
I
V
V
V
V
E
C
T
M
Q
L
S
G
E
Y
L
-----------------------------------
V
R
L
Y
L
V
D
L
I
L
V
I
I
L
W
A
D
Y
A
Y
R
A
Y
K
S
G
D
P
A
G
Y
V
--
K
K
--
T
L
Y
E
I
P
A
L
V
P
A
G
L
L
A
L
I
E
G
H
L
A
G
L
----------
G
L
F
R
L
V
R
L
L
--
R
F
L
R
I
L
-----------------
L
---
I
I
S
R
G
S
K
F
L
S
A
I
---------
A
D
A
A
D
K
I
R
F
Y
H
L
F
G
A
V
M
L
T
V
---
L
Y
G
A
F
A
I
Y
I
V
E
------
Y
-----
P
DPNSS------------------------------------------
I
K
S
V
F
D
A
L
W
W
A
V
V
T
A
T
T
V
G
Y
G
D
V
V
P
A
T
P
I
G
K
V
I
G
I
A
V
M
L
T
G
I
S
A
L
T
L
L
I
G
T
V
S
N
M
F
Q
K
I
L
-------------------------------------------------------
125
Fugue
59.81
16%
-116
- C6 -
3BEH
7
CNGK1_RHILO
A:
[7-228]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRI
Y
A
P
L
N
A
V
L
A
A
P
G
L
L
A
V
A
A
L
T
I
P
D
M
S
G
R
S
---------
R
-----------------------------------
L
A
L
A
A
L
L
A
V
I
W
G
A
Y
L
L
Q
L
A
A
T
L
L
K
R
R
A
G
V
V
R
D
R
T
P
K
--
I
A
I
D
V
L
A
V
L
V
P
L
A
A
F
L
LDGS--------------
P
D
W
S
L
Y
C
A
V
--
W
L
L
K
P
L
-----------------
R
---
D
S
T
F
F
P
V
---
L
G
---------
R
V
L
A
N
E
A
R
N
L
I
G
V
T
T
L
F
G
V
V
---
L
F
A
V
A
L
A
A
Y
V
I
ERDIQP
E
-----
K
-----------------------------------------------
F
G
S
I
P
Q
A
M
W
W
A
V
V
T
L
S
T
T
G
Y
G
D
T
I
P
Q
S
F
A
G
R
V
L
A
G
A
V
M
M
S
G
I
G
I
F
G
L
W
A
G
I
L
A
T
G
F
Y
Q
E
V
R
R
G
D
F
-
V
R
N
W
Q
--------------------------------------------
4
PsiBlast_PDB
59.38
27%
-160
- C5 -
1ORQ
6
KVAP_AERPE
C:
[42-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
D
L
I
L
V
I
I
L
W
A
D
Y
A
Y
R
A
Y
K
S
G
D
P
A
G
Y
V
--
K
K
--
T
L
Y
E
I
P
A
L
V
P
--------------------------
A
G
L
L
A
L
I
E
G
H
L
A
G
L
G
L
F
R
L
V
R
L
L
R
F
L
R
I
L
L
I
I
S
---
R
G
S
K
F
L
S
---
A
I
A
D
A
A
D
K
I
R
F
Y
H
L
F
G
A
V
M
L
T
V
L
Y
G
A
F
A
I
Y
I
---
V
E
Y
P
D
P
----
N
------
S
-----
S
-----------------------------------------------
I
K
S
V
F
D
A
L
W
W
A
V
V
T
A
T
T
V
G
Y
G
D
V
V
P
A
T
P
I
G
K
V
I
G
I
A
V
M
L
T
G
I
S
A
L
T
L
L
I
G
T
V
S
N
M
F
Q
----------------------------------------------------------
66
PsiBlast_CBE
58.64
37%
-161
- C5 -
3F5W
2
KCSA_STRLI
C:
[10-94]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
A
T
V
L
L
V
I
V
L
L
A
G
S
Y
L
A
V
L
A
E
R
G
A
P
G
------
A
-----
Q
-----------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
C
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
-----------------------------------------------------------
106
HHSearch
58.40
31%
-131
- C5 -
3EFF
-
?
K:
[32-158]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
L
L
V
I
V
L
---
L
A
G
S
Y
L
A
V
L
A
E
------
R
-----
G
APGAQ------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
L
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
V
G
R
E
Q
E
R
R
G
H
F
V
R
H
S
EKA
A
E
E
A
Y
T
R
T
T
R
A
L
-
H
E
R
F
D
R
L
E
R
M
L
D
D
N
--------------
122
Fugue
58.31
31%
-147
- C5 -
1K4C
4
KCSA_STRLI
C:
[22-124]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
H
W
R
A
A
G
A
A
T
V
L
L
V
I
V
L
---
L
A
G
S
Y
L
A
V
L
A
E
------
R
GAPGA
Q
-----------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
C
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
V
G
R
E
Q
E
R
R
G
-
H
------------------------------------------------
127
Fugue
58.24
19%
-144
- C6 -
2R9R
13
KCNA2_RAT (first)
B:
[51-436]
S
E
R
V
V
I
N
I
SG
L
R
F
E
T
Q
L
K
T
L
A
Q
FPETLLGDPKKRMRYFDPLRN
E
Y
F
F
DRNRPS
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
R
R
PVNVP
L
D
I
F
S
E
E
I
R
F
Y
ELG
E
E
A
M
E
M
F
R
E
D
E
G
Y
I
K
E
E
E
R
P
L
PENEF
Q
R
Q
V
W
L
L
F
E
YPESS
G
P
A
R
I
I
A
I
V
S
V
M
V
I
L
I
S
I
V
S
F
C
L
E
TLPIFRDENEDMHGGGVT
F
H
T
Y
S
Q
S
T
I
G
Y
Q
Q
S
TSFT
D
P
F
F
I
V
E
T
L
C
I
I
W
F
S
F
E
F
L
V
R
F
F
A
C
P
S
K
---------
A
-----------------------------------
G
F
F
T
N
I
M
N
I
I
D
I
V
A
I
I
P
Y
Y
V
T
I
F
L
T
E
S
N
------------
K
S
V
L
Q
F
Q
N
V
R
R
V
V
-------------------
Q
I
F
R
I
M
R
I
L
--
R
I
F
K
L
S
-----------------
R
---
H
S
K
G
L
Q
I
---
L
G
---------
Q
T
L
K
A
S
M
R
E
L
G
L
L
I
F
F
L
F
I
G
---
V
I
L
F
S
S
A
V
Y
F
A
E
ADERD
S
-----
Q
-----------------------------------------------
F
P
S
I
P
D
A
F
W
W
A
V
V
S
M
T
T
V
G
Y
G
D
M
V
P
T
T
I
G
G
K
I
V
G
S
L
C
A
I
A
G
V
L
T
I
A
L
P
V
P
V
I
V
S
N
F
N
Y
F
Y
H
R
E
T
---------------------------------------------------
65
PsiBlast_CBE
57.55
37%
-158
- C5 -
3F7V
2
?
C:
[9-94]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
A
T
V
L
L
V
I
V
L
L
A
G
S
Y
L
A
V
L
A
E
R
G
A
P
G
------
A
-----
Q
-----------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
C
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
-----------------------------------------------------------
124
Fugue
55.84
32%
-156
- C5 -
1BL8
3
KCSA_STRLI
A:
[1-97]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
H
W
R
A
A
G
A
A
T
V
L
L
V
I
V
L
---
L
A
G
S
Y
L
A
V
L
A
E
RGAPG-
A
-----
Q
-----------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
C
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
V
G
R
E
Q
------------------------------------------------------
112
HHSearch
55.10
19%
-143
- C5 -
3UKM
5
KCNK1_HUMAN
A:
[11-158]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
F
G
F
L
V
L
G
Y
L
L
Y
L
---
V
F
G
A
V
V
F
S
S
V
E
------
L
-----
P
Y
E
D
L
L
R
Q
E
L
R
K
L
K
R
R
F
L
E
E
HECLS
E
Q
Q
L
E
Q
F
L
G
R
V
L
E
A
S
N
Y
GVSVLW
N
W
D
F
T
S
A
L
F
F
A
S
T
V
L
S
T
T
G
Y
G
H
T
V
P
L
S
D
G
G
K
A
F
C
I
I
Y
S
V
I
G
I
P
F
T
L
L
F
L
T
A
V
V
Q
R
I
T
V
H
V
T
R
-----------------------------------------------------
104
HHSearch
54.57
29%
-150
- C5 -
3PJS
-
?
K:
[27-158]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
G
A
A
T
V
L
L
V
I
V
L
---
L
A
G
S
Y
L
A
V
L
A
E
------
R
-----
G
APGAQ------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
L
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
V
G
Q
E
Q
Q
Q
Q
Q
Q
F
V
R
H
S
EKA
A
E
E
A
Y
T
R
T
T
R
A
L
-
H
E
R
F
D
R
L
E
R
M
L
D
D
N
--------------
123
Fugue
54.54
30%
-152
* C5 *
1JVM
4
KCSA_STRLI
A:
[24-120]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
W
R
A
A
G
A
A
T
V
L
L
V
I
V
---
L
L
A
G
S
Y
L
A
V
L
A
E
RGAPG
A
-----
Q
-----------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
C
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
V
G
R
E
Q
E
-----------------------------------------------------
108
HHSearch
54.37
34%
-157
- C5 -
2A9H
-
KCSA_STRLI
A:
[36-119]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
V
---
L
L
A
G
S
Y
L
A
V
L
A
------
E
-----
R
GAPGAA-----------------------------------------
L
I
S
Y
P
D
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
C
V
A
V
V
V
M
V
A
G
I
T
S
Y
G
L
V
F
A
A
V
A
T
W
F
V
G
R
E
Q
------------------------------------------------------
63
PsiBlast_CBE
53.43
37%
-142
- C5 -
3FB5
4
KCSA_STRLI
C:
[6-94]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
A
A
G
A
A
T
V
L
L
V
I
V
L
L
A
G
S
Y
L
A
V
L
A
E
R
G
A
P
G
------
A
-----
Q
-----------------------------------------------
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
L
Y
P
V
T
L
W
G
R
C
V
A
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
F
-----------------------------------------------------------