@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2068: (2016-03-31 )
MAKDIKFSEDARRAMLRGVDQLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDPFENMGAKLVSEVASKTNDVAGDGTTTATVLAQAMIQEGLKNVTAGANPVGVRRGIEKAVATAIEELKAISKPIESKESIAQVAAISSGDEEVGKLIAEAMERVGNDGVITIEESKGFATELDVVEGMQFDRGYTSPYMVTDSDKMEAVLEKPYILITDKKINNIQEILPVLEQVVQQGRPMLIIAEDVEGEAQATLVLNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGQVITEDLGLELKTATVDQLGTANKVVVTKDDTTIVEGAGDSTQISARVNQIRAQMEETTSEFDREKLQERLAKLAGGVAVVKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVSIYNKVAALEAEGDVETGINIVLRSLEEPVRQIAHNAGLEGSVIVERLKHEAVGVGFNAANGEWVNMIDAGIVDPTKVTRSALQNASSVAALLLTTEAVVADKPDENGPAAVPDMGMGGMGGMM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.-.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420......-.430........440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKDIK
F
S
E
D
A
R
R
A
M
L
R
G
V
D
Q
L
A
N
A
V
K
V
T
LGPKG
R
N
V
V
L
EKKFGSPLITNDG
V
T
I
A
K
E
I
ELED
P
F
E
N
M
G
A
K
L
V
S
E
V
A
S
KTNDVAGDG
T
T
T
A
T
V
L
A
Q
A
M
I
Q
E
G
L
K
N
VTAGA
N
P
V
G
V
R
R
G
I
E
K
A
V
A
T
A
I
E
E
L
K
A
I
SKPI
E
S
K
E
S
I
A
Q
V
A
AISS-G-
D
E
E
V
G
K
L
I
A
E
A
M
E
R
VGND
G
V
I
T
I
EESKGFAT
E
L
D
V
V
EGMQFDRGYTS
P
Y
M
VT
D
S
D
K
M
E
A
V
L
EK
P
Y
I
L
I
TDKKIN
N
I
Q
E
I
L
P
V
L
E
Q
V
V
QQGR
P
M
L
I
I
AEDVEGE
A
Q
A
T
L
V
L
N
K
LRG
T
F
N
V
V
A
V
KAPGF
G
D
R
R
K
A
M
L
E
D
I
A
I
LTG
G
Q
V
I
T
E
DLG
L
E
L
K
T
A
T
V
DQLGTA
N
K
V
V
V
TKDD
T
T
I
V
EGAGDS
T
Q
I
S
A
R
V
N
Q
I
R
A
Q
M
E
E
T
T
S
E
F
D
R
E
K
L
Q
E
R
L
A
K
LAG
G
V
A
V
V
K
VGAA
T
E
T
E
L
K
E
R
K
L
R
I
E
D
A
L
N
S
T
R
A
A
V
E
E
G
IVAGG
G
T
A
L
V
S
I
Y
N
K
V
A
ALE-AEG-D
V
E
T
G
I
N
I
V
L
R
S
L
E
E
P
V
R
Q
I
A
H
NAGL
E
G
S
V
I
V
E
R
L
K
H
EAVG
V
G
FNAANG
E
W
V
N
M
IDAGIV
D
P
T
K
V
T
R
S
A
L
Q
N
A
S
S
V
A
A
L
L
L
T
T
E
A
VVADKPDENGPAAVPDMGMGGMGGMM
85
PsiBlast_CBE
94.37
63%
-76
- C4 -
1MNF
3
CH60_ECOLI
J:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
91
PsiBlast_CBE
94.35
63%
-75
- C4 -
1MNF
3
CH60_ECOLI
D:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
69
PsiBlast_CBE
94.14
63%
-76
- C4 -
1XCK
2
CH60_ECOLI
M:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
93
PsiBlast_CBE
94.13
63%
-75
- C4 -
1MNF
3
CH60_ECOLI
B:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
83
PsiBlast_CBE
94.12
63%
-75
- C4 -
1MNF
3
CH60_ECOLI
L:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
72
PsiBlast_CBE
94.12
63%
-75
- C4 -
1XCK
2
CH60_ECOLI
J:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
88
PsiBlast_CBE
94.09
63%
-75
- C4 -
1MNF
3
CH60_ECOLI
G:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
80
PsiBlast_CBE
94.09
63%
-77
- C4 -
1XCK
1
CH60_ECOLI
B:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
86
PsiBlast_CBE
94.07
63%
-75
- C4 -
1MNF
3
CH60_ECOLI
I:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
198
HHSearch
93.87
63%
-74
- C4 -
1KP8
3
CH60_ECOLI
A:
[1-525]
A
A
K
D
V
K
F
G
N
D
A
G
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
V
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
-
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
A
-
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-------------------
11
PsiBlast_PDB
93.87
63%
-75
- C4 -
2NWC
-
CH60_ECOLI
A:
[3-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
81
PsiBlast_CBE
93.80
63%
-75
- C4 -
1MNF
2
CH60_ECOLI
N:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
14
PsiBlast_PDB
93.78
63%
-73
- C4 -
4HEL
-
?
A:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
6
PsiBlast_PDB
93.75
63%
-74
- C4 -
1MNF
3
CH60_ECOLI
A:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
90
PsiBlast_CBE
93.74
63%
-75
- C4 -
1MNF
3
CH60_ECOLI
E:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
92
PsiBlast_CBE
93.71
63%
-75
- C4 -
1MNF
3
CH60_ECOLI
C:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
87
PsiBlast_CBE
93.71
63%
-74
- C4 -
1MNF
2
CH60_ECOLI
H:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
70
PsiBlast_CBE
93.61
63%
-74
- C4 -
1XCK
1
CH60_ECOLI
L:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
68
PsiBlast_CBE
93.56
63%
-73
- C4 -
1XCK
1
CH60_ECOLI
N:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------
82
PsiBlast_CBE
93.55
63%
-74
- C4 -
1MNF
2
CH60_ECOLI
M:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
-
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
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A
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A
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R
Q
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I
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A
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D
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E
K
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V
A
K
L
A
G
G
V
A
V
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K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
-
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
--------------------