@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2095: (2016-03-31 )
MIYTITLNPAIDRLLFIQGELEKRKTNRVKKTEFDCGGKGLHVSGVLSKFGIKNEALGIAGSDNLDKLYAILKEKHINHDFLVEAGTSTRECFVVLSDDTNGSTMIPEAGFTVSQTNKVNLLKQIAKKVKKEDMVVIAGSPPPHYTLSDFKELLRTVKATGAFLGCDNSGEYLNLAVEMGVDFIKPNEDEVIAILDEKTNSLEENVRKLAEKIPYLVVSLGAKGSICAHNGKLYQVIPPKVQERNDTGAGDVFVGAFIAGLAMNMPITETLKVATGCSASKVMQQDSSSFDLEAAGKLKNQVSIIQLEER
Atome Classification :
(20 SA)
-.........10...-----.....20........30........40........50........60..-......70........80........90........100..-.....110...---.----...-120.......130..-.....140.......150.......160.......170---......--.-180........190...----....200---.---...----.---..-.210.----.------......220.......230.......240.......250.......260..-.-....270--.......280.....-..290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
I
Y
T
I
TLNPAI
D
R
L
-----
L
F
IQG
E
L
E
K
RKTNRVKKTEFDCGGKGL
H
V
S
G
V
L
S
K
FGIKNEALGIAGSD-
N
L
D
K
L
Y
A
I
L
K
E
KHI
N
H
D
F
L
V
EAGTST
R
E
C
F
V
V
L
SDDTNGST-MIPEAG
F
T
VSQ---T----
N
K
V
-
N
L
L
K
Q
I
A
K
K
VKKE
D
M
-
V
V
I
AGSPPPHY
T
L
S
D
F
K
E
L
L
R
T
V
K
AT
G
A
F
L
GCDNSG
E
Y
---
L
N
L
A
V
E
--M-G-VDFIKPNED
E
V
I
A
I
L----DEKT
N
S
----
L
---
E
E
N
----
V
---
R
K
-
L
A
-
E
K----I------
P
Y
L
V
V
SLGAKG
S
I
CAHN
G
K
L
Y
Q
VIPP
K
V
QERNDTGA
G
D
V
F
V
G
A
F
I
A
G
L
AMN-M-PIT
E
T
L
K
--VATGC
S
A
S
K
V
M
Q
QDS-SSF
D
L
E
A
A
GKLKN
Q
V
S
I
I
Q
LEER
3
PsiBlast_PDB
98.05
96%
-100
- C1 -
3IE7
3
?
A:
[3-310]
-
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
-----
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
T
N
G
S
T
-
M
I
P
E
A
G
F
T
V
S
Q
---
T
----
N
K
D
-
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
-
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
E
--
M
-
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
T
N
S
----
L
---
E
E
N
----
I
---
R
T
-
L
A
-
E
K
----
I
------
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
-
M
-
P
I
T
E
T
L
K
--
V
A
T
G
C
S
A
S
K
V
M
Q
Q
D
S
-
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
1
PsiBlast_PDB
97.95
97%
-99
- C1 -
3Q1Y
2
?
A:
[3-311]
-
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
-----
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
T
N
G
S
T
-
M
I
P
E
A
G
F
T
V
S
Q
---
T
----
N
K
D
-
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
-
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
E
--
M
-
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
T
N
S
----
L
---
E
E
N
----
I
---
R
T
-
L
A
-
E
K
----
I
------
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
-
M
-
P
I
T
E
T
L
K
--
V
A
T
G
C
S
A
S
A
V
M
Q
Q
D
S
-
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
E
-
2
PsiBlast_PDB
97.27
96%
-101
- C1 -
3HIC
1
?
A:
[3-311]
-
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
-----
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
T
N
G
S
T
-
M
I
P
E
A
G
F
T
V
S
Q
---
T
----
N
K
D
-
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
-
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
E
--
M
-
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
T
N
S
----
L
---
E
E
N
----
I
---
R
T
-
L
A
-
E
K
----
I
------
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
-
M
-
P
I
T
E
T
L
K
--
V
A
T
G
C
S
A
S
K
V
M
Q
Q
-----
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
E
-
56
HHSearch
96.79
95%
-99
- C1 -
3IE7
3
?
A:
[3-310]
-
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
-----
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
N
L
-
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
T
N
G
S
T
-
M
I
P
E
A
G
F
T
V
S
Q
T
N
K
D
----
N
L
L
K
Q
I
A
K
K
V
K
K
----
E
D
M
-
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
E
--
M
-
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
T
N
S
----
L
---
E
E
N
----
I
---
R
T
-
L
A
-
E
K
----
I
------
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
-
M
-
P
I
T
E
T
L
K
--
V
A
T
G
C
S
A
S
K
V
M
Q
Q
D
S
-
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
4
PsiBlast_PDB
95.46
96%
-107
- C1 -
3JUL
2
?
A:
[3-310]
-
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
-----
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
T
N
G
S
T
-
M
I
P
E
A
G
F
T
V
S
Q
---
T
----
N
K
D
-
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
-
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
E
--
M
-
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
T
N
S
----
L
---
E
E
N
----
I
---
R
T
-
L
A
-
E
K
----
I
------
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
-------
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
-
M
-
P
I
T
E
T
L
K
--
V
A
T
G
C
S
A
S
K
V
M
Q
Q
-----
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
76
Fugue
92.42
93%
-91
- C1 -
3HIC
1
?
A:
[2-311]
S
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
-----
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
T
N
G
S
T
M
I
P
E
A
-
G
F
T
V
S
Q
---
T
----
N
K
D
-
N
L
L
K
Q
I
A
K
K
-
V
K
K
E
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
E
---
M
G
-
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
T
N
S
----
L
---
E
E
N
----
I
---
R
T
-
L
A
-
E
K
----
I
------
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
--
A
M
N
M
P
I
T
E
T
L
K
--
V
A
T
G
C
S
A
S
K
-----
V
M
Q
Q
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
E
-
15
PsiBlast_PDB
71.64
27%
-88
- C1 -
2JGV
-
LACC_STAA8
A:
[22-330]
--
I
L
T
L
T
L
N
P
S
V
D
-
I
-----
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
Q
--
Q
T
-
E
I
L
E
Q
G
P
E
I
D
N
---
Q
----
E
A
A
-
G
F
I
K
H
F
E
Q
L
L
E
K
V
E
A
-
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
NP
Y
-
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
NQPL
D
E
S
L
E
S
----
L
---
K
Q
A
----
V
---
S
Q
P
L
F
-
E
G
----
I
------
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
-
E
-
N
D
H
D
L
L
K
--
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
-
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
---
17
PsiBlast_PDB
70.17
27%
-84
- C1 -
2JG1
2
LACC_STAA8
A:
[22-330]
--
I
L
T
L
T
L
N
P
S
V
D
-
I
-----
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
Q
--
Q
T
-
E
I
L
E
Q
G
P
E
I
D
N
---
Q
----
E
A
A
-
G
F
I
K
H
F
E
Q
M
M
E
K
V
E
A
-
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
NP
Y
-
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
NQPL
D
E
S
L
E
S
----
L
---
K
Q
A
----
V
---
S
Q
P
L
F
-
E
G
----
I
------
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
-
E
-
N
D
H
D
L
L
K
--
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
-
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
---
16
PsiBlast_PDB
68.52
27%
-82
- C1 -
2Q5R
-
LACC_STAAC
A:
[2-310]
--
I
L
T
L
T
L
N
P
S
V
D
-
I
-----
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
Q
--
Q
T
-
E
I
L
E
Q
G
P
E
I
D
N
---
Q
----
E
A
A
-
G
F
I
K
H
F
E
Q
L
L
E
K
V
E
A
-
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
NP
Y
-
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
NQPL
D
E
S
L
E
S
----
L
---
K
Q
A
----
V
---
S
Q
P
L
F
-
E
G
----
I
------
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
-
E
-
N
D
H
D
L
L
K
--
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
-
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
---
14
PsiBlast_PDB
68.15
27%
-96
- C1 -
3UQD
6
PFKB_ECOLI
A:
[4-287]
--
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
------
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
-
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
A
S
G
E
Q
Y
-
R
F
V
M
P
G
A
A
L
N
E
---
D
----
E
F
R
-
Q
L
E
E
Q
V
L
E
-
I
E
S
G
A
I
-
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
----
N
R
E
L
T
Q
--------
P
D
D
----
V
---
R
K
-
A
A
-
Q
E
----
I
V
N
S
GKA
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
-
A
-
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
-------------------------------
11
PsiBlast_PDB
67.86
27%
-97
- C1 -
3N1C
2
PFKB_ECOLI
A:
[4-287]
--
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
------
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
-
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
A
S
G
E
Q
Y
-
R
F
V
M
P
G
A
A
L
N
E
---
D
----
E
F
R
-
Q
L
E
E
Q
V
L
E
-
I
E
S
G
A
I
-
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
----
N
R
E
L
T
Q
--------
P
D
D
----
V
---
R
K
-
A
A
-
Q
E
----
I
V
N
S
GKA
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
-
A
-
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
-------------------------------
9
PsiBlast_PDB
67.62
27%
-79
- C1 -
2F02
1
LACC_ENTFA
A:
[3-313]
-
L
I
V
T
V
T
M
N
P
S
I
D
-
I
-----
S
Y
L
L
D
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
-
T
S
I
K
E
E
T
R
D
S
I
A
I
L
H
E
--
G
N
Q
T
-
E
I
L
E
A
G
P
T
V
S
P
---
E
----
E
I
S
-
N
F
L
E
N
F
D
Q
L
I
K
Q
A
E
I
-
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
Q
GP
W
-
K
-
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
--
D
F
S
E
N
P
----
L
---
A
A
V
----
Q
---
T
A
-
L
T
-
K
P
MFAG
I
------
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
-
A
-
P
A
A
E
L
L
K
--
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
-
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
---
5
PsiBlast_PDB
67.54
30%
-77
- C1 -
2JG5
-
?
A:
[1-304]
-
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
-----
I
F
T
N
-
D
F
K
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
-
I
E
V
D
E
D
T
R
---
I
N
V
K
L
K
T
G
Q
E
T
-
E
I
N
A
P
G
P
H
I
T
S
---
T
----
Q
F
E
-
Q
L
L
Q
Q
I
-
K
N
T
T
S
E
D
I
-
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
P
--
Y
-
H
-
P
L
F
I
K
P
N
K
D
E
L
E
V
M
F
----
N
T
T
V
N
S
----
D
---
A
D
V
----
I
K
Y
G
R
L
-
L
V
-
D
K
G---
A
------
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
-
L
-
S
I
E
K
A
F
Q
--
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
L
-
A
T
R
D
--
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
D
--
7
PsiBlast_PDB
67.52
28%
-89
- C1 -
3UQE
4
PFKB_ECOLI
A:
[4-289]
--
I
Y
T
L
T
L
A
P
S
L
D
S
A
-----
T
-
I
T
P
Q
I
D
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
-
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
A
S
G
E
Q
Y
-
R
F
V
M
P
G
A
A
L
N
E
---
D
----
E
F
R
-
Q
L
E
E
Q
V
L
E
-
I
E
S
G
A
I
-
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
----
N
R
E
L
T
Q
--------
P
D
D
----
V
---
R
K
-
A
A
-
Q
E
----
I
V
N
S
GKA
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
-
A
-
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
-------------------------------
10
PsiBlast_PDB
67.36
27%
-94
- C1 -
3CQD
7
PFKB_ECOLI
A:
[4-292]
--
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
------
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
-
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
A
S
G
E
Q
Y
-
R
F
V
M
P
G
A
A
L
N
E
---
D
----
E
F
R
-
Q
L
E
E
Q
V
L
E
-
I
E
S
G
A
I
-
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
----
N
R
E
L
T
Q
--------
P
D
D
----
V
---
R
K
-
A
A
-
Q
E
----
I
V
N
S
GKA
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
-
A
-
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
-------------------------------
8
PsiBlast_PDB
67.23
27%
-79
- C1 -
2AWD
6
LACC_ENTFA
A:
[3-313]
-
L
I
V
T
V
T
M
N
P
S
I
D
-
I
-----
S
Y
L
L
D
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
-
T
S
I
K
E
E
T
R
D
S
I
A
I
L
H
E
--
G
N
Q
T
-
E
I
L
E
A
G
P
T
V
S
P
---
E
----
E
I
S
-
N
F
L
E
N
F
D
Q
L
I
K
Q
A
E
I
-
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
Q
G
P
W
-
K
-
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
--
D
F
S
E
N
P
----
L
---
A
A
V
----
Q
---
T
A
-
L
T
-
K
P
MFAG
I
------
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
-
A
-
P
A
A
E
L
L
K
--
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
-
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
---
58
HHSearch
66.83
30%
-80
- C1 -
2JG5
-
?
A:
[1-304]
-
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
-----
I
F
T
N
D
F
K
-
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
I
E
V
D
-
E
D
T
R
I
N
V
K
L
--
K
-
T
G
Q
E
T
-
E
I
N
A
P
G
P
H
I
T
S
---
T
----
Q
F
E
-
Q
L
L
Q
Q
I
K
N
-
T
T
S
E
D
I
-
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
---
P
Y
H
-
P
L
F
I
K
P
N
K
D
E
L
E
V
M
F
----
N
T
T
V
N
S
----
D
A
D
V
I
K
Y
----
G
---
R
L
-
L
V
D
K
G
----
A
------
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
-
L
-
S
I
E
K
A
F
Q
--
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
---
L
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
D
--
60
HHSearch
66.67
27%
-79
* C1 *
2F02
1
LACC_ENTFA
A:
[3-314]
-
L
I
V
T
V
T
M
N
P
S
I
D
I
S
-----
Y
L
L
D
H
-
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
T
S
I
-
K
E
E
T
R
D
S
I
A
I
L
H
E
--
G
N
Q
T
-
E
I
L
E
A
G
P
T
V
S
P
---
E
----
E
I
S
-
N
F
L
E
N
F
D
Q
L
I
K
Q
A
E
I
-
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
Q
GP
W
-
K
-
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
----
G
Q
D
F
S
E
N---
P
---
L
A
A
V
Q
T
A
L
---
T
K
-
P
M
F
A
G
----
I
------
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
-
A
-
P
A
A
E
L
L
K
--
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
-
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
A
--
13
PsiBlast_PDB
65.98
27%
-94
- C1 -
3UMP
7
PFKB_ECOLI
A:
[4-287]
--
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
------
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
-
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
A
S
G
E
Q
Y
-
R
F
V
M
P
G
A
A
L
N
E
---
D
----
E
F
R
-
Q
L
E
E
Q
V
L
E
-
I
E
S
G
A
I
-
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
----
N
R
E
L
T
Q
--------
P
D
D
----
V
---
R
K
-
A
A
-
Q
E
----
I
V
N
S
GKA
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
-
A
-
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
-------------------------------
57
HHSearch
65.81
27%
-80
- C1 -
2JG1
2
LACC_STAA8
A:
[21-330]
-
M
I
L
T
L
T
L
N
P
S
V
D
I
S
-----
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
E
T
R
N
C
I
A
I
L
H
--
E
G
Q
Q
T
-
E
I
L
E
Q
G
P
E
I
D
N
---
Q
E
A
A
G
F
I
K
-
H
F
E
Q
M
M
E
K
----
V
E
A
-
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
Q
T
V
L
E
N
P
---
Y
-
K
-
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
----
N
Q
P
L
D
E
S
L
E
S
L
---
K
Q
A
----
V
---
S
Q
-
P
L
F
E
G
----
I
------
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
-
E
-
N
D
H
D
L
L
K
--
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
-
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
---