@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2105: (2016-03-31 )
MSQNTYCLLGNPNTGKTSLFNALTGSYEYVGNWSGVTVEKKVGTLRSKTGKLIDLPGIYDLNPISRDETVVTRFLLEEKFDCMLNIVDSSQIERNLNLTIQLLEFGAPVVMGLNMIDVAAGRGIHLNIQNLAKKLRIPILPVVARSGKGTDDILTTLSEKHVAPAIPLVLPYGEPAEKAIAEIQALTKDIIPTKQSRWLAVQFLSKNEVTEEFLTTSPMFEQLKDIRSDLEIALAGKLENHFHQVRVNYIHDICLTSVEYTRNSDIPLSDKLDKIFTHKFFGIPIFLGIMWLIFQITFTWVGAPLSDLLDGFIGGSLTDWVTSFLTTIGASGFITDLVADGIIAGVGGVLVFVPQILVIFFFISVLEDSGYMARIAVVMDRVMEIFGLNGKAFIPMIIGFGCNVPGIMAARSIEESKERTLTILVSPFMSCSARLPVYALFVGVFFEKYQALVVLSLYVIGILMALIVTKILSKTLLKKDNSVFVVELPPYRLPSLKTLWRSTWEKGKGFLRKAGTFIFAGSVIIWLLNYAGPSGLDVPMGESFLAIIGGMLAPLLVPLGFGTWQAGATLIPGFLAKEVVVSTMAIIYAVGESSMGSIVSTFYTPLSAYCFMLFILLYIPCLATVAAIRKETSSWKWTAFAVAYPLITAYVLVFLVYQIGSLFV
Atome Classification :
(45 SA)
.........10........20........30........40..--.--..--...--50--........60..----.-..----...70........80........90........100.......110.......120.......130.......140.......150.......160....--.-..170........180.......190.......200.......210......-.220........230.......240----.........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQN
T
Y
C
L
L
GNPNTG
K
T
S
L
F
N
A
LTGS
Y
E
Y
VGNWS
G
V
T
V
E
K
K
V
G
--
T
--
L
R
--SKT--G
K
--
L
IDLPGIYDLNP----I-S
R
----
D
E
T
V
V
T
R
F
L
L
E
E
K
F
D
C
M
L
N
IV
D
S
S
Q
I
ERNL
N
L
T
I
Q
L
LEFGA
P
V
V
M
G
L
N
M
I
D
VAAG
R
G
I
H
L
N
I
Q
N
L
A
K
K
LRI
P
I
L
P
V
V
ARSGK
G
T
D
D
I
L
T
T
L
SEKHVAPAI--
P
-
L
V
LP-YGE
P
A
E
K
A
I
A
E
I
Q
A
L
T
K
D
IIPTKQS
R
W
L
A
V
Q
F
LSK
N
E
V
T
E
E
FLTT
S
P
-
M
F
E
-
Q
L
K
D
I
R
SDL
E
I
A
L
A
G
K
L
E
N
------
H
F
H
Q
V
R
V
N
Y
I
H
D
I
C
LT
S
V
E
YTRNSDIPL
S
D
K
L
D
K
I
F
T
H
KFF
G
I
P
I
F
L
G
I
M
W
L
I
F
Q
I
T
F
T
WVGA
P
L
S
D
L
L
D
G
F
IGG
S
L
T
D
W
V
T
S
F
L
T
T
IGAS
G
F
I
T
D
L
V
A
D
G
I
I
A
GV
G
G
V
L
V
F
V
P
Q
I
L
V
I
F
F
F
I
S
V
L
EDSG
Y
M
A
R
I
A
V
V
M
D
R
V
M
E
I
FGLNG
K
A
F
I
P
M
I
I
GFGCNV
P
G
I
M
A
A
R
S
I
E
ESKE
R
T
L
T
I
L
V
S
P
F
M
S
CSAR
L
P
V
Y
A
L
F
V
G
V
F
F
E
K
Y
Q
A
L
V
V
L
S
L
Y
V
I
G
I
L
M
A
L
I
V
T
K
I
L
S
K
T
L
LKKDN
S
V
F
V
V
ELPPYRL
P
S
L
K
T
L
W
R
S
T
W
E
K
G
K
G
F
L
R
KA
G
T
F
I
F
A
G
S
V
I
I
W
L
LNYAGPSGLDVPM
G
E
S
F
L
A
I
I
G
G
M
L
A
P
L
L
V
PLGFGTWQAG
A
T
L
I
P
G
F
L
A
K
E
V
V
V
S
T
M
A
I
I
Y
AVGE
S
S
M
G
S
I
V
S
T
F
Y
T
P
L
S
A
Y
C
F
M
L
F
I
L
L
Y
I
P
C
L
A
T
V
A
A
I
R
KETSS
W
K
W
T
A
F
A
V
A
Y
P
L
I
T
A
Y
V
L
V
F
L
V
Y
Q
I
G
SLFV
26
PsiBlast_CBE
92.12
34%
-92
- C5 -
3TAH
3
?
B:
[7-264]
------
A
L
I
G
N
P
A
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.49
34%
-96
- C5 -
3B1W
1
?
A:
[7-263]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
A
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.93
34%
-92
- C5 -
3TAH
3
?
A:
[7-261]
------
A
L
I
G
N
P
A
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.46
35%
-92
- C5 -
4NON
1
?
A:
[5-255]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
S
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.44
34%
-88
- C5 -
3B1V
3
?
A:
[7-266]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
A
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
H
T
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
90.27
34%
-90
- C5 -
3B1V
3
?
A:
[3-262]
--
M
T
E
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
--
K
N
K
D-
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
A
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
L
A
F
P
I
-
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
-
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
90.05
35%
-86
- C5 -
3I8S
-
FEOB_ECOLI
A:
[1-262]
M
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
--
T
T
D
HQ
V
T
--
L
V
D
L
P
G
T
Y
S
L
T
T
-----T
S
L
----
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
----
E
L
V
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
A
G
E
A
S
---
Q
-
H
L
D
A
A
L
A
R
L
R
N
E
M
-
D
D
P
A
L
------
H
I
A
D
A
R
Y
Q
C
I
A
A
I
C
D
V
V
S
N
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
89.82
35%
-99
- C5 -
4NON
1
?
B:
[5-255]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
--
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
S
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
89.70
34%
-92
- C5 -
3B1W
1
?
C:
[7-262]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
A
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
-----
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.69
34%
-93
- C5 -
3LX8
1
?
A:
[7-260]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
89.63
34%
-93
- C5 -
3B1W
1
?
B:
[7-261]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
A
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.17
34%
-93
- C5 -
3B1Y
1
?
A:
[7-261]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
A
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
----
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.00
34%
-92
- C5 -
3B1W
1
?
D:
[7-259]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
A
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
------
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.84
34%
-90
- C5 -
3B1Z
1
?
A:
[7-259]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
S
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
------
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.46
34%
-87
- C5 -
3LX5
3
?
A:
[7-267]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
--------
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
H
T
E
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
87.24
34%
-94
- C5 -
3I8S
-
FEOB_ECOLI
B:
[1-261]
M
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
T
T
D
H
Q
--
V
T
--
L
V
D
L
P
G
T
Y
S
L
T
T
ISSQ
T
-
S
L
----
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
---
V
-
E
L
V
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
A
--
G
E
-
A
S
Q
-
H
L
D
A
A
L
A
R
L
R
N
E
M
-
D
D
P
A
L
------
H
I
A
D
A
R
Y
Q
C
I
A
A
I
C
D
V
V
S
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.88
34%
-90
- C5 -
3B1X
2
?
A:
[7-261]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
A
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.71
34%
-89
- C5 -
3B1X
2
?
B:
[7-259]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
A
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.69
35%
-84
- C5 -
2WIB
2
?
A:
[1-256]
M
Q
K
L
T
V
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
A
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
I
--
F
A
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
-
S
S
QTS
L
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
M
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
V
V
A
L
N
M
L
D
I
A
E
K
Q
Q
V
R
I
D
I
D
A
L
A
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
I
A
L
-
D
R
H
Q
A
N
S
D
--
L
-
E
L
V
H
-
Y
P
Q
P
L
L
R
E
A
D
L
L
A
Q
Q
M
S
A
Q
I
P
P
R
Q
R
R
W
L
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
-----------
A
G
D
A
A
D
K
L
D
I
A
L
A
N
L
S
D
E
IDD
P
A
L
H
I
A
D
A
R
Y
Q
T
I
A
A
I
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.64
34%
-93
- C5 -
3SS8
4
?
A:
[7-259]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
85.75
35%
-91
- C5 -
2WIB
2
?
B:
[1-256]
M
Q
K
L
T
V
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
A
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
I
--
F
A
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
---L---
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
M
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
V
V
A
L
N
M
L
D
I
A
E
K
Q
Q
V
R
I
D
I
D
A
L
A
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
I
A
L
-
D
R
H
Q
A
N
S
D
--
L
-
E
L
V
H
-
Y
P
Q
P
L
L
R
E
A
D
L
L
A
Q
Q
M
S
A
Q
I
P
P
R
Q
R
R
W
L
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
-----------
A
G
D
A
A
D
K
L
D
I
A
L
A
N
L
S
D
E
IDD
P
A
L
H
I
A
D
A
R
Y
Q
T
I
A
A
I
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.56
34%
-89
- C5 -
3SS8
4
?
B:
[7-259]
------
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
--
L
--
V
K
K-
N
K
D
--
L
E
--
I
Q
D
L
P
G
I
Y
S
M
S
P
----
Y
-
S
P
----
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
--
D
-
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
-
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
------
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.34
35%
-96
- C5 -
2WIC
3
?
A:
[1-256]
M
Q
K
L
T
V
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
A
R
Q
------------
K
E
G
--
I
--
F
A
--
T
T
D
--
H
Q
VT
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
-
S
S
----
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
M
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
V
V
A
L
N
M
L
D
I
A
E
K
Q
Q
V
R
I
D
I
D
A
L
A
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
I
A
L
-
D
R
H
Q
A
N
S
D
--
L
-
E
L
V
H
-
Y
P
Q
P
L
L
R
E
A
D
L
L
A
Q
Q
M
S
A
Q
I
P
P
R
Q
R
R
W
L
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
-----------
A
G
D
A
A
D
K
L
D
I
A
L
A
N
L
S
D
E
IDD
P
A
L
H
I
A
D
A
R
Y
Q
T
I
A
A
I
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.94
39%
-99
- C5 -
3I92
2
FEOB_ECOLI
A:
[1-210]
M
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
---------QTS
L
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
82.49
39%
-92
- C5 -
3I8X
1
FEOB_ECOLI
B:
[1-210]
M
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
-
S
S
QTS
L
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
81.81
39%
-96
- C5 -
4R98
1
FEOB_ECOLI
B:
[2-211]
-
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
-
S
-TS
L
-
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
A
T
D
T
K
N
V
Q
F
V
L
K
L
A
I
D
R
Y
K
A
N
E
N
--
V
-
E
L
V
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
81.42
36%
-86
- C5 -
3A1T
1
?
A:
[9-211]
------
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
G
V
F
T
--
Y
K
--
G
Y
T
--
I
N
--
L
I
D
L
P
G
T
Y
S
L
G
Y
----
S
-
S
I
----
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
I
L
H
R
-
M
I
L
D
-
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
R
Y
F
A
L
K
Y
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
81.35
39%
-90
- C5 -
3I92
2
FEOB_ECOLI
B:
[2-210]
-
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
-
S
S
QTS
L
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
81.33
36%
-82
- C5 -
3A1U
5
?
A:
[9-211]
------
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
G
V
F
T
--
Y
K
--
G
Y
T
--
I
N
--
L
I
D
L
P
G
T
Y
S
L
G
Y
----
S
-
S
I
----
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
I
--
R
-
M
I
L
D
-
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
R
Y
F
A
L
K
Y
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
81.22
39%
-92
- C5 -
3I8X
1
FEOB_ECOLI
C:
[1-210]
M
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
VT
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
-
S
S
QTSL
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
79.80
39%
-89
- C5 -
3I92
2
FEOB_ECOLI
C:
[2-210]
-
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
VT
L
V
D
L
P
G
T
Y
S
L
T
T
----
I
-
S
S
QTSL
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.63
39%
-92
- C5 -
3HYT
2
FEOB_ECOLI
A:
[2-210]
-
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
---------
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
---------S
L
--
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
77.42
36%
-83
- C5 -
3A1U
5
?
B:
[9-211]
------
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
----
T
V
E
K
K
E
G
V
F
T
--
Y
K
--
G
Y
T
--
I
N
--
L
I
D
L
P
G
T
Y
S
L
G
Y
----
S
-
S
I
----
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
----
R
-
M
I
L
D
-
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
R
Y
F
A
L
K
Y
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
76.66
39%
-92
- C5 -
3HYT
2
FEOB_ECOLI
B:
[2-210]
-
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
---------
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
---------
S
L
--
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
76.43
39%
-90
- C5 -
3HYT
2
FEOB_ECOLI
C:
[2-210]
-
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
---------
R
K
E
G
--
Q
--
F
S
--
T
T
D
--
H
Q
VT
L
V
D
L
P
G
T
Y
S
L
---------------
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
--
E
-
L
V
-
H
-
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
76.31
40%
-82
* C5 *
2WJG
1
FEOB_METJA
A:
[6-170]
-
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
--
E
--
F
E
--
Y
N
G
E
K
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
K
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
76.27
41%
-89
- C5 -
2WJG
1
FEOB_METJA
B:
[5-164]
M
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
--
E
--
F
E
Y
N
G
E
K
--
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
75.87
41%
-90
- C5 -
2WJG
1
FEOB_METJA
A:
[5-164]
M
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
--
E
--
F
E
Y
N
G
E
K
--
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
74.68
41%
-88
- C5 -
2WJH
3
FEOB_METJA
A:
[1-160]
M
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
--
E
--
F
E
Y
N
G
E
K
--
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
74.64
41%
-85
- C5 -
2WJH
2
FEOB_METJA
B:
[1-160]
M
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
--
E
--
F
E
YN
G
E
K
--
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
74.28
41%
-90
- C5 -
2WJI
3
FEOB_METJA
A:
[2-163]
-
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
-----
T
V
E
K
K
E
G
--
E
--
F
E
--
Y
N
G
E
K
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.03
41%
-94
- C5 -
2WJI
3
FEOB_METJA
A:
[1-160]
M
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
-----
T
V
E
K
K
E
G
--
E
--
F
E
Y
N
G
E
K
--
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
73.97
41%
-95
- C5 -
2WJI
3
FEOB_METJA
B:
[1-160]
M
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
---------
V
E
K
K
E
G
--
E
--
F
E
Y
N
G
E
K
--
F
K
--
V
V
D
L
P
G
V
Y
S
L
T
A
----
N
-
S
I
----
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
72.46
39%
-83
- C5 -
3W5J
2
?
A:
[2-166]
-
Q
F
K
R
I
A
L
L
G
M
P
N
T
G
K
S
T
L
F
N
R
M
T
G
G
A
A
R
V
G
N
W
P
G
I
T
V
E
L
L
S
G
--
K
--
I
L
--
L
G
A
D
M
V
E
--
I
I
D
L
P
G
I
Y
D
L
H
G
----
F
-
S
D
----
D
E
Q
V
V
R
H
F
L
H
D
N
V
P
D
L
A
L
V
I
L
N
A
T
Q
I
E
R
Q
M
S
L
L
L
Q
L
K
Q
L
N
M
N
I
V
V
L
L
N
M
S
D
E
A
K
Q
Y
G
I
T
I
D
S
R
K
M
S
E
L
L
Q
I
P
V
F
Q
L
S
----
T
G
Y
Q
E
A
L
Q
A
V
T
R
A
L
R
Y
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.49
40%
-91
- C5 -
3W5J
2
?
A:
[7-161]
------
A
L
L
G
M
P
N
T
G
K
S
T
L
F
N
R
M
T
G
G
A
A
R
V
G
N
W
P
G
I
T
V
E
L
L
S
G
--
K
I
L
L
G
--
A
D
M
--
V
E
--
I
I
D
L
P
G
I
Y
D
L
H
G
----
F
-
S
D
----
D
E
Q
V
V
R
H
F
L
H
D
N
V
P
D
L
A
L
V
I
L
N
A
T
Q
I
E
R
Q
M
S
L
L
L
Q
L
K
Q
L
N
M
N
I
V
V
L
L
N
M
S
D
E
A
K
Q
Y
G
I
T
I
D
S
R
K
M
S
E
L
L
Q
I
P
V
F
Q
L
S
----
T
G
Y
Q
E
A
L
Q
A
V
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------