@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2118: (2016-04-01 )
MGKYFGTDGVRGVANSELTPELAFRLGRMGGYVLTRHVGEHPRVLVARDTRISGEMLESALIAGLVSVGIEVMRLGVISTPGVAYLTKAQGASASVMISASHNPVDDNGIKFFGSDGFKLSDDQEEEIEQLLDTAEDTLPRPSGEGLGTVSDYFEGKQKYIQYLKQTIENDFNGYHIALDCANGATSGLATHLFADLDADISSMGASPNGLNINDGVGSTHPEALAAFVLDKKADVGLAFDGDGDRVIAIDEIGQIVDGDKIMFICAKYLREQGLLNNNTIVSTVMSNLGFYKGLKELEIEDVQTAVGDRYVVEAMREGNYNLGGEQSGHIIFLDHNTTGDGLLSGIQLINVMKATGKKLSELAAEMKTFPQKLENIRVSDKNHVTDNPKVSKVIDEVEAEMAGNGRVLVRPSGTEPLVRVMVEAATKEETDEYCERISAVVRSEMALND
Atome Classification :
(20 SA)
-----.........10.-..-.....20.......-.30........40..-......50........60........70........80........90........100.......110.......120.......130....------...140......-.150.........160.......-170-..---....--...180.......190....-...200.......210......--.220..---..-------....---.230.---......240.......250.......260.....-..270...--.--.....280.......290.......300.......310.......320.......330....-..-.340.......350.......360.......370.-.......380--..---...----...--------390.......400-----------.---------..-----------------....---------------.410.......420.......430.......440.......450-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MGKYFGTDGVRG-VA-NSEL
T
P
E
L
A
F
R
L
GR-M
G
G
Y
V
L
T
R
HVGEHP
R
-
V
L
V
A
RDTRI
S
G
E
M
L
E
S
A
L
I
A
G
L
V
S
V
G
I
E
V
M
R
L
GVISTPG
V
A
Y
L
TKAQGA
S
A
S
V
M
I
SASHNPVDDN
G
I
K
F
FGSDGFKLSDD
Q
E
E
E
I
E
Q
L
L
D
T
A
E
------DTLPRPSGEGLG-
T
V
--
S
D
Y
F
E
G
K
Q
K
Y
I
Q
Y
L
K
Q
T
I
E-N---DF---N
G
Y
H
--
I
A
L
DCANGAT
S
G
L
A
T
H
L
F
A
D-LDA
D
I
S
SMGASPNGLNINDGVG--ST--
H
P
---
E
A
-------
L
A
A
F
---
V
LDKK---AD
V
G
L
A
FDGDG
D
R
V
I
A
I
D
E
I
G
Q
IVDGDK
I
M
F
I
C
A
-
K
Y
L
--
R
EQ--G--LLNN
N
T
I
V
S
T
V
M
SN
L
G
F
Y
K
G
L
K
E
L
E
I
E
D
V
Q
T
AVG
D
R
Y
V
V
E
A
M
R
EGNYNLGGEQS
G
H
I
I
F
L
DH-NT-T
G
D
G
L
L
S
G
I
Q
L
I
N
V
M
K
A
T
G
K
K
L
S
E
L
A
A
E
M
K
T
F
P
-
Q
-
K
L
E
NIRVS-D--KN---HVT----DNP--------
K
V
S
K
V
I
D
E
V
E
A
E
------------M---------AG-----------------N
G
R
V
---------------
L
V
RPSGT
E
P
L
V
R
V
M
V
E
AAT
K
E
E
T
D
E
Y
C
E
R
I
S
A
V
V
R
S
E
MALND---
25
HHSearch
99.81
70%
-89
- C1 -
3PDK
3
GLMM_BACAN
A:
[23-467]
------
G
K
Y
F
G
T
D
G
V
R
G
-
V
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
-
F
G
G
Y
V
L
T
K
D
-
T
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
D
K
E
V
------
D
E
L
P
R
P
T
G
T
N
L
G
-
Q
V
--
S
D
Y
F
E
G
G
Q
K
Y
L
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
---
S
G
L
H
--
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
-
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
N
I
N
D
G
V
G
--
S
T
--
H
P
---
E
V
-------
L
A
E
L
---
V
K
E
K
G
---
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
-
K
Y
M
--
K
E
T
--
G
--
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
Y
-
I
T
-
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
A
G
E
M
T
K
F
P
-
Q
-
L
L
V
N
V
R
V
T
-
D
--
K
K
---
L
A
L
----
E
N
E
--------
K
I
K
E
I
I
R
V
V
E
E
E
------------
M
---------
N
G
-----------------
D
G
R
I
---------------
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
------
1
PsiBlast_PDB
99.53
70%
-89
- C1 -
3PDK
3
GLMM_BACAN
A:
[23-466]
------
G
K
Y
F
G
T
D
G
V
R
G
-
V
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
-
F
G
G
Y
V
L
T
K
D
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
D
K
E
V
------
D
E
L
P
R
P
T
G
T
N
L
G
-
Q
V
--
S
D
Y
F
E
G
G
Q
K
Y
L
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
---
S
G
L
H
--
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
-
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
N
I
N
D
G
V
G
--
S
T
--
H
P
---
E
V
-------
L
A
E
L
---
V
K
E
K
G
---
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
-
K
Y
M
--
K
E
T
--
G
--
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
Y
-
I
T
-
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
A
G
E
M
T
K
F
P
-
Q
-
L
L
V
N
V
R
V
T
-
D
--
K
K
---
L
A
L
----
E
N
E
--------
K
I
K
E
I
I
R
V
V
E
E
E
------------
M
---------
N
G
-----------------
D
G
R
I
---------------
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
-------
21
PsiBlast_CBE
99.16
70%
-90
- C1 -
3PDK
5
GLMM_BACAN
B:
[24-466]
-------
K
Y
F
G
T
D
G
V
R
G
-
V
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
-
F
G
G
Y
V
L
T
K
D
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
D
K
E
V
------
D
E
L
P
R
P
T
G
T
N
L
G
-
Q
V
--
S
D
Y
F
E
G
G
Q
K
Y
L
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
---
S
G
L
H
--
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
-
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
N
I
N
D
G
V
G
--
S
T
--
H
P
---
E
V
-------
L
A
E
L
---
V
K
E
K
G
---
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
-
K
Y
M
--
K
E
T
--
G
--
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
Y
-
I
T
-
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
A
G
E
M
T
K
F
P
-
Q
-
L
L
V
N
V
R
V
T
-
D
--
K
K
---
L
A
L
----
E
N
E
--------
K
I
K
E
I
I
R
V
V
E
E
E
------------
M
---------
N
G
-----------------
D
G
R
I
---------------
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
-------
2
PsiBlast_PDB
84.28
38%
-78
- C1 -
3I3W
1
GLMM_FRATT
A:
[3-442]
-------
K
Y
F
G
T
D
G
I
R
G
E
V
A
-
N
S
T
I
T
V
E
F
T
Q
K
L
G
N
-
A
V
G
S
L
I
N
Q
K
--
N
Y
P
K
F
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
E
E
E
V
E
D
M
I
D
G
--------
D
F
I
Y
Q
P
Q
F
K
-
F
G
-
S
Y
--
K
I
L
A
N
A
I
D
E
Y
I
E
S
I
Y
S
R
F
A
-
K
----
F
---
V
N
Y
K
G
K
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
-
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
L
N
I
N
V
G
C
G
--
A
T
--
C
V
---
S
N
-------
I
K
K
A
---
V
K
E
Q
K
---
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
A
-
Q
Y
S
--
D
I
C
--
G
----
G
T
N
G
I
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
F
-
G
T
-
T
G
D
G
L
F
T
A
I
Q
L
L
A
I
F
S
Q
A
D
K
P
V
S
E
F
K
L
Q
G
E
L
M
Q
-
Q
-
T
L
I
N
V
P
L
T
-
K
--
K
V
---
A
R
E
----
D
L
Q
--------
K
V
A
S
D
V
N
D
V
E
K
R
------------
L
---------
G
N
-----------------
R
G
R
V
---------------
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
-------
28
HHSearch
83.27
39%
-76
- C1 -
3I3W
1
GLMM_FRATT
A:
[3-442]
-------
K
Y
F
G
T
D
G
I
R
G
-
E
V
A
N
S
T
I
T
V
E
F
T
Q
K
L
G
N
-
A
V
G
S
L
I
N
Q
K
-
N
Y
P
K
F
-
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
E
E
E
V
E
D
M
I
D
G
D
---------
F
I
Y
Q
P
Q
F
K
F
G
-
S
Y
--
K
I
L
A
N
A
I
D
E
Y
I
E
S
I
Y
S
R
F
A
K
F
---
V
N
---
Y
K
G
K
--
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
-
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
L
N
I
N
V
G
C
G
--
A
T
--
C
V
---
S
N
-------
I
K
K
A
---
V
K
E
Q
K
---
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
A
-
Q
Y
S
--
D
I
C
--
G
----
G
T
N
G
I
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
F
-
G
T
-
T
G
D
G
L
F
T
A
I
Q
L
L
A
I
F
S
Q
A
D
K
P
V
S
E
F
K
L
Q
G
E
L
M
Q
-
Q
-
T
L
I
N
V
P
L
T
-
K
--
K
V
A
R
-
E
D
L
----
Q
----------
K
V
A
S
D
V
N
D
V
E
K
R
------------
L
---------
G
N
-----------------
R
G
R
V
---------------
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
-------
27
HHSearch
77.91
33%
-65
* C1 *
1WQA
1
?
A:
[1-454]
-----
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
E
D
--------
F
D
R
A
K
W
Y
E
I
G
-
E
V
--
R
R
E
-
D
I
I
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
E
A
I
K
K
---
R
K
P
F
--
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
-
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
F
P
A
R
N
P
E
PN
E
E
--
N
L
---
K
E
-------
F
M
E
I
---
V
K
A
L
G
---
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
-
D
A
V
--
L
K
E
--
K
----
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H
-
V
L
-
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
-
I
K
T
K
R
H
V
E
G
D
--
R
H
---
A
I
V
N
K
V
A
E
M
A
R
E
R
G----
Y
T
V
D
T
T
D
G
A
K
I
I
------------
F
----------
E
-----------------
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
-------
23
PsiBlast_CBE
76.88
34%
-74
- C1 -
1WQA
1
?
C:
[1-443]
-----
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
--
F
K
------
E
D
F
D
R
A
K
W
Y
E
I
G
-
E
V
RR
E
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
IKK
R
K
P
F
--
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
-
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
--
A
R
--
N
P
---
E
P
NEEN---
L
K
E
F
---
M
E
I
V
K
ALG
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
--
K
E
K
GG
G
--
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
-----
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H
-
V
L
-
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
-------
I
K
-
T
--
K
R
---
H
V
E
----
G
D
R
--------
H
A
--
I
V
N
K
V
-
A
E
------------
M
---------
A
R
ERGYTVDTTDGAKIIFE
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
------------------
3
PsiBlast_PDB
76.69
34%
-73
- C1 -
1WQA
1
?
A:
[1-443]
-----
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
--
F
K
------
E
D
F
D
R
A
K
W
Y
E
I
G
-
E
V
R
R
E
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
I
K
K
R
K
P
F
--
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
-
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
--
A
R
--
N
P
---
E
P
NEEN---
L
K
E
F
---
M
E
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
--
K
E
K
G
G
G
--
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
-----
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H
-
V
L
-
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
-------
I
K
-
T
--
K
R
---
H
V
E
----
G
D
R
--------
H
A
--
I
V
N
K
V
-
A
E
------------
M
---------
A
R
E
R
G
Y
T
V
D
TTD
G
A
K
I
I
F
E
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
------------------
22
PsiBlast_CBE
76.35
34%
-74
- C1 -
1WQA
1
?
D:
[1-443]
-----
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
--
F
K
------
E
D
F
D
R
A
K
W
Y
E
I
G
-
E
V
RR
E
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
IKK
R
K
P
F
--
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
-
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
--
A
R
--
N
P
---
E
P
NEEN---
L
K
E
F
---
M
E
I
V
K
ALG
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
--
K
E
K
GG
G
--
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
-----
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H
-
V
L
-
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
-------
I
K
-
T
--
K
R
---
H
V
E
----
G
D
R
--------
H
A
--
I
V
N
K
V
-
A
E
------------
M
---------
A
R
ERGYTVDTTDGAKIIFE
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
------------------
24
PsiBlast_CBE
76.18
34%
-74
- C1 -
1WQA
1
?
B:
[1-443]
-----
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
--
F
K
------
E
D
F
D
R
A
K
W
Y
E
I
G
-
E
V
RR
E
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
IKK
R
K
P
F
--
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
-
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
--
A
R
--
N
P
---
E
P
NEEN---
L
K
E
F
---
M
E
I
V
K
ALG
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
--
K
E
K
GG
G
--
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
-----
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H
-
V
L
-
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
-------
I
K
-
T
--
K
R
---
H
V
E
----
G
D
R
--------
H
A
--
I
V
N
K
V
-
A
E
------------
M
---------
A
R
ERGYTVDTTDGAKIIFE
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
------------------
4
PsiBlast_PDB
75.27
28%
-63
- C1 -
2F7L
1
?
A:
[1-452]
-----
M
G
K
L
F
G
T
D
G
V
R
G
-
I
V
-
N
K
E
L
T
P
E
L
V
L
K
L
S
K
-
A
I
G
T
F
F
----
G
K
N
S
K
-
I
L
V
G
R
D
V
R
A
G
G
D
M
L
V
K
I
V
E
G
G
L
L
S
V
G
V
E
V
Y
D
G
G
M
A
P
T
P
A
L
Q
Y
A
V
K
T
L
G
Y
D
G
G
V
V
I
T
A
S
H
N
P
A
P
Y
N
G
I
K
V
V
D
K
D
G
I
E
I
R
R
E
K
E
N
E
I
E
D
L
F
F
T
E
R
FNTIEW
S
S
L
T
T
E
V
K
R
E
D
R
-
V
I
--
S
T
Y
V
N
G
I
L
S
H
V
D
I
E
K
I
K
K
K
-
N
----------
Y
K
--
V
L
I
D
P
A
N
-
S
V
G
A
L
S
T
P
L
V
A
R
A
L
G
C
K
I
Y
T
I
----
N
G
-
N
L
D
P
L
F
S
--
A
R
--
Q
P
---
E
P
TFDSL
K
E
T
A
E
V
---
V
K
T
L
K
---
V
D
L
G
V
A
H
D
G
D
A
D
R
A
I
F
I
D
S
E
G
R
V
Q
W
G
D
R
S
G
T
L
L
S
-
Y
W
A
--
S
V
K
--
N
--
P
K
A
I
K
K
I
V
T
A
V
S
S
S
S
L
V
E
E
Y
L
S
K
Y
N
I
Q
V
D
W
T
K
V
G
S
V
D
I
A
H
K
V
A
D
E
N
A
L
A
G
F
E
E
N
G
G
F
M
Y
P
P
H
-
Q
Y
-
V
R
D
G
A
M
S
F
A
L
M
L
E
L
L
A
N
E
N
V
S
S
A
E
L
F
D
R
L
P
K
Y
----
Y
L
V
K
T
K
V
D
-
L
--
K
P
---
G
L
M
----
V
E
E
--------
I
Y
K
K
I
L
E
V
Y
S
T
S
S
V
K
A
I
TIDG
V
K
I
I
---------
G
K
-----------------
D
F
W
F
---------------
L
V
R
K
S
G
T
E
P
I
I
R
I
M
A
E
A
K
D
E
N
V
A
N
N
L
V
N
E
L
K
K
I
V
-----------
48
Fugue
75.02
25%
-63
- C1 -
1K2Y
2
ALGC_PSEAE
X:
[5-463]
KAPTL
P
A
S
I
F
R
A
Y
D
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
-
A
I
G
S
E
S
L
A
R
--
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
G
E
T
L
A
N
----
E
Q
I
Q
A
L
R
E
R
I
E
------
K
---
N
D
L
A
S
G
V
G
-
S
V
--
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
-
M
---
A
----
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
---
E
N
-------
L
K
D
L
IAK
V
K
A
E
N
---
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
--
V
S
R
--
N
----
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
-
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
-
S
T
P
E
I
N
I
T
V
T
-
E
--
D
S
---
K
F
A
----
I
I
E
--------
A
L
Q
R
D
A
Q
W
G
E
G
N
------------
I
TTLDGVRVD
Y
P
-----------------
K
G
W
G
---------------
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
S
S
L
P
VPF
26
HHSearch
74.29
28%
-64
- C1 -
2F7L
1
?
A:
[1-454]
-----
M
G
K
L
F
G
T
D
G
V
R
G
-
I
V
-
N
K
E
L
T
P
E
L
V
L
K
L
S
K
-
A
I
G
T
F
F
G
K
N
----
S
K
-
I
L
V
G
R
D
V
R
A
G
G
D
M
L
V
K
I
V
E
G
G
L
L
S
V
G
V
E
V
Y
D
G
G
M
A
P
T
P
A
L
Q
Y
A
V
K
T
L
G
Y
D
G
G
V
V
I
T
A
S
H
N
P
A
P
Y
N
G
I
K
V
V
D
K
D
G
I
E
I
R
R
E
K
E
N
E
I
E
D
L
F
F
T
E
R
--------
F
N
T
I
E
W
S
S
L
T
T
E
V
--
K
R
E
D
R
V
I
S
T
Y
V
N
G
I
L
S
H
V
D
-
I
E
K
I
K
K
---
K
N
Y
K
--
V
L
I
D
P
A
N
S
V
G
A
L
S
T
P
L
V
A
R
A
-
L
G
C
K
I
Y
T
I
N
G
N
L
D
P
L
F
S
A
R
Q
P
E
--
P
T
FD
S
L
---
K
E
-------
T
A
E
V
---
V
K
T
L
K
---
V
D
L
G
V
A
H
D
G
D
A
D
R
A
I
F
I
D
S
E
G
R
V
Q
W
G
D
R
S
G
T
L
L
S
-
Y
W
A
--
S
V
K
--
N
--
P
K
A
I
K
K
I
V
T
A
V
S
S
S
S
L
V
E
E
Y
L
S
K
Y
N
I
Q
V
D
W
T
K
V
G
S
V
D
I
A
H
K
V
A
D
E
N
A
L
A
G
F
E
E
N
G
G
F
M
Y
P
P
H
-
Q
Y
-
V
R
D
G
A
M
S
F
A
L
M
L
E
L
L
A
N
E
N
V
S
S
A
E
L
F
D
R
L
P
K
Y
Y
-
L
-
V
K
T
K
V
D
L
K
-
P
--
G
L
M
V
E
E
I
Y
----
K
K
I
L
E
V
YSTSS
V
K
A
I
T
I
D
G
V
K
I
I
------------
G
----------
K
-----------------
D
F
W
F
---------------
L
V
R
K
S
G
T
E
P
I
I
R
I
M
A
E
A
K
D
E
N
V
A
N
N
L
V
N
E
L
K
K
I
V
E
G
---------
11
PsiBlast_PDB
73.31
27%
-64
- C1 -
1PCJ
2
ALGC_PSEAE
X:
[19-456]
--------------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
--
G
E
-
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
------------
L
A
S
G
V
G
-
S
V
------
E
Q
V
D
I
L
P
R
Y
F
K
Q
-
I
R
-
D
---
D
I
AMA
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
---
E
N
-------
L
K
D
L
---
I
A
K
V
K
AEN
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
VS
R
N
P
--
G
AD
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
------
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
-
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
-
D
I
S
T
P
E
I
N
-
I
--
T
-----
V
T
----
E
D
S
--------
K
F
A
-
I
I
E
A
L
Q
R
D
A-----------
Q
---------
W
G
-----------------
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
----
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
---
12
PsiBlast_PDB
73.28
27%
-66
- C1 -
1PCM
2
ALGC_PSEAE
X:
[19-456]
--------------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
--
G
E
-
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
------------
L
A
S
G
V
G
-
S
V
------
E
Q
V
D
I
L
P
R
Y
F
K
Q
-
I
R
-
D
---
D
I
AMA
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
---
E
N
-------
L
K
D
L
---
I
A
K
V
K
AEN
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
VS
R
N
P
--
G
AD
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
------
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
-
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
-
D
I
S
T
P
E
I
N
-
I
--
T
-----
V
T
----
E
D
S
--------
K
F
A
-
I
I
E
A
L
Q
R
D
A-----------
Q
---------
W
G
-----------------
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
----
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
---
6
PsiBlast_PDB
73.23
27%
-66
- C1 -
1K2Y
2
ALGC_PSEAE
X:
[19-456]
--------------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
--
G
E
-
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
------------
L
A
S
G
V
G
-
S
V
------
E
Q
V
D
I
L
P
R
Y
F
K
Q
-
I
R
-
D
---
D
I
AMA
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
---
E
N
-------
L
K
D
L
---
I
A
K
V
K
AEN
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
VS
R
N
P
--
G
AD
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
------
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
-
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
-
D
I
S
T
P
E
I
N
-
I
--
T
-----
V
T
----
E
D
S
--------
K
F
A
-
I
I
E
A
L
Q
R
D
A-----------
Q
---------
W
G
-----------------
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
----
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
---
30
HHSearch
73.10
27%
-61
- C1 -
1P5D
2
ALGC_PSEAE
X:
[11-457]
------
A
S
I
F
R
A
Y
D
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
-
A
I
G
S
E
S
L
A
R
--
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
--------
L
A
----
S
G
V
G
-
S
V
--
E
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
-----
M
A
---
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
ENL
K
D
-------
L
I
A
K
---
V
K
A
E
N
---
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
--
V
S
R
--
N
----
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
-
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
-
P
E
I
N
I
T
V
T
-
E
DS
K
F
---
A
I
I
----
E
A
L
QRDAQWGE
G
N
I
T
T
L
D
G
V
R
V
D
------------
Y
----------
P
-----------------
K
G
W
G
---------------
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
S
------
8
PsiBlast_PDB
72.99
27%
-63
- C1 -
2H5A
2
ALGC_PSEAE
X:
[19-456]
--------------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
--
G
E
-
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
------------
L
A
S
G
V
G
-
S
V
------
E
Q
V
D
I
L
P
R
Y
F
K
Q
-
I
R
-
D
---
D
I
AMA
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
---
E
N
-------
L
K
D
L
---
I
A
K
V
K
AEN
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
VS
R
N
P
--
G
AD
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
------
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
-
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
-
D
I
S
T
P
E
I
N
-
I
--
T
-----
V
T
----
E
D
S
--------
K
F
A
-
I
I
E
A
L
Q
R
D
A-----------
Q
---------
W
G
-----------------
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
----
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
---
9
PsiBlast_PDB
72.37
27%
-64
- C1 -
1P5D
2
ALGC_PSEAE
X:
[19-456]
--------------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
--
G
E
-
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
------------
L
A
S
G
V
G
-
S
V
------
E
Q
V
D
I
L
P
R
Y
F
K
Q
-
I
R
-
D
---
D
I
AMA
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
---
E
N
-------
L
K
D
L
---
I
A
K
V
K
AEN
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
VS
R
N
P
--
G
AD
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
------
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
-
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
-
D
I
S
T
P
E
I
N
-
I
--
T
-----
V
T
----
E
D
S
--------
K
F
A
-
I
I
E
A
L
Q
R
D
A-----------
Q
---------
W
G
-----------------
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
----
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
---
18
PsiBlast_PDB
72.28
27%
-66
- C1 -
1K35
1
ALGC_PSEAE
A:
[19-456]
--------------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
--
G
E
-
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
------------
L
A
S
G
V
G
-
S
V
------
E
Q
V
D
I
L
P
R
Y
F
K
Q
-
I
R
-
D
---
D
I
AM
A
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
-
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
--
P
G
--
K
P
---
E
N
-------
L
K
D
L
---
I
A
K
V
K
A
EN
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
-
K
D
V
V
S
R
N
P
--
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
------
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
-
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
-
D
I
S
T
P
E
I
N
-
I
--
T
-----
V
T
----
E
D
S
--------
K
F
A
-
I
I
E
A
L
Q
R
D
A
-----------
Q
---------
W
G
-----------------
E
G
N
I
TTL
D
G
V
R
V
D
YP
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
----
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
---