@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2133: (2016-04-01 )
MLVNMKQLLEVAKENKFAVGAFNVADSNFLRVVVEEAEKNNAPAIIAVHPTELDFTKDDFFQYVLARIKNSPVPFVLHLDHGDNMGDVMRAVRCGFSSVMIDGSLLPFEENIRVTKEVVDVCHKLGVSVEGELGTIGKTGNSIEGGVSEIIYTKPEEAEEYISRTGVDTLAVAIGTAHGIYPKDKEPKLRLDILKEIKALVNIPLVLHGGSANPDAEIAAAVEIGIQKVNISSDYKYAFYKKCREILSTTELWDANAIYPDCIDAAKEVVKYKMGLFESIGQVEKYQQAKTTAWRSELI
Atome Classification :
(32 SA)
---.........10........20........30........40........50......-.----..60....-----.--....------70.-.......80.-----------.......90........100.......110.......120.......130.......140.--......150.......160.......170.......180.......190-........200-.......---------------210--------------------...---------------------.---------------------.------...220.......230.......240....-...-250-.--.......260-.......270.......280.......290.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MLV
N
M
K
Q
L
L
E
V
A
KEN
K
F
A
V
G
A
F
NVAD
S
N
F
L
R
V
V
V
E
E
AEKNNA
P
A
I
I
A
V
HP-TELDF
T
-
K
----
D
D
F
-
F
Q
Y
V
-----
L
--
A
R
IK------NSP-V
P
F
V
L
H
LDHG-----------D
N
M
G
D
V
M
R
A
V
R
CGF
S
S
V
M
IDGSLLP
F
E
E
N
I
R
V
T
K
E
V
V
D
V
C
H
KLGV
S
V
EGELGTIGKTGNSI--EGG
V
S
E
I
I
YTK
P
E
E
A
E
E
Y
I
S
RTG
V
D
T
L
A
V
A
IGTAHGIYPKDKEP
K
L
R
L
--
D
I
L
K
E
I
K
A
L
VN-I
P
L
V
L
HG---------------GS---------------------ANP---------------------D---------------------
A
------
E
I
A
A
A
V
E
I
G
I
Q
K
V
NISSD
Y
K
Y
A
F
Y
K
K
C
R
E
I
-
L
S
T
-T-E-L--WDANAIY
P
D
C
-
I
D
A
A
K
E
V
V
K
Y
K
M
G
L
F
E
S
I
G
Q
V
E
K
Y
Q
Q
A
K
T
T
A
W
RSELI
25
PsiBlast_CBE
96.52
37%
-100
- C4 -
1RV8
6
?
C:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
--
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
26
PsiBlast_CBE
96.25
37%
-105
- C4 -
1RV8
6
?
B:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
--
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
23
PsiBlast_CBE
96.01
37%
-104
- C4 -
1RVG
6
?
B:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
--
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
22
PsiBlast_CBE
95.83
37%
-104
- C4 -
1RVG
6
?
C:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
--
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
24
PsiBlast_CBE
95.66
37%
-103
- C4 -
1RV8
6
?
D:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
--
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
1
PsiBlast_PDB
95.32
37%
-101
- C4 -
1RV8
7
?
A:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
----------
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAAGIH
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
50
HHSearch
94.95
39%
-94
- C4 -
1RVG
8
?
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
--------
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAA
G
I
H
---------------------
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
----------------
2
PsiBlast_PDB
94.61
37%
-97
- C4 -
1RVG
8
?
A:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
--------
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAAGIH
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
21
PsiBlast_CBE
94.54
37%
-99
- C4 -
1RVG
5
?
D:
[1-304]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
L
M
A
-----
V
--
E
L
A
K
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
--
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
-
L
N
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
12
PsiBlast_PDB
93.02
34%
-97
- C4 -
3C56
3
ALF_HELPY
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
N
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
33
PsiBlast_CBE
92.03
34%
-95
- C4 -
3N9R
2
?
U:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
NVRKSYLDAGGDLKGSKGVPF
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
10
PsiBlast_PDB
91.64
34%
-103
- C4 -
3C4U
2
ALF_HELPY
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
-----------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
N
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
32
PsiBlast_CBE
91.62
34%
-98
- C4 -
3N9R
14
?
Z:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
NVRKSYLDAGGDLKGSKGVPF
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
38
PsiBlast_CBE
91.09
34%
-102
- C4 -
3C4U
2
ALF_HELPY
B:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
-----------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
NVRKSYLDAGGDLKGSKGVPF
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
37
PsiBlast_CBE
91.08
34%
-98
- C4 -
3C56
3
ALF_HELPY
B:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
---------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
N
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
13
PsiBlast_PDB
90.71
34%
-95
- C4 -
3N9R
4
?
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
N
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
5
PsiBlast_PDB
90.66
35%
-97
- C4 -
2FJK
1
ALF_THECA
A:
[2-304]
----
L
V
T
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
-
G
A
M
K
Y
G
-
G
----
R
A
L
-
T
R
M
V
-----
V
--
A
L
A
Q
------
E
A
R
-
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
--
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
P
R
L
A
R
I
A
K
L
V
P
-
A
P
L
V
L
H
G
---------------
A
S
---------------------
A
V
P
---------------------
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
EASGIH
P
E
------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
-
L
G
K
-
N
P
K
-
E
--
F
D
P
R
K
Y
L
G
P
A
-
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
-----------------
36
PsiBlast_CBE
90.55
34%
-93
- C4 -
3N9R
4
?
B:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
NVRKSYLDAGGDLKGSKGVPF
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
34
PsiBlast_CBE
90.45
34%
-94
- C4 -
3N9R
4
?
P:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
NVRKSYLDAGGDLKGSKGVPF
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
35
PsiBlast_CBE
90.22
34%
-92
- C4 -
3N9R
4
?
K:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
NVRKSYLDAGGDLKGSKGVPF
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
49
HHSearch
90.08
35%
-98
- C4 -
2ISW
2
?
A:
[2-317]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
-
G
A
L
K
Y
S
D
M
----
I
Y
L
-
K
K
L
C
-----
E
--
A
A
L
E
K
-----
H
P
D
-
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
---------------
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
K
S
--
R
L
A
I
--
D
R
V
K
T
I
S
D
L
T
G
-
I
P
L
V
M
H
G
---------------
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
---------------------
I
---------------------
E
------
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
-
F
V
E
-
H
P
E
-
K
--
F
D
P
R
D
Y
L
G
P
G
-
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
------
11
PsiBlast_PDB
89.28
34%
-92
- C4 -
3C52
4
ALF_HELPY
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
-
G
A
I
K
Y
M
-
G
----
I
D
M
A
V
G
M
V
-----
K
--
I
M
C
E
------
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
-------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
T
N
-
I
P
L
V
L
H
G
---------------
A
S
---------------------
A
I
P
---------------------
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
GSKGVP
F
E
------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
-
A
N
E
-
D
-
K
S
Q
--
F
D
L
R
K
F
F
S
P
A
-
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
30
PsiBlast_CBE
89.25
34%
-102
- C4 -
2ISV
2
?
B:
[3-311]
----
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
-
G
A
L
K
Y
S
-
D
----
M
I
Y
-
L
K
K
L
-----
C
E
A
A
L
E
K
------
H
P
D
-
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
-----------
Q
N
T
V
Q
---
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
-----
I
R
L
A
I
D
R
V
K
T
I
S
D
L
T
G
-
I
P
L
V
M
H
G
SSSVP
K
D
V
K
D
M
I
N
K
Y
G
G
---------------------
K
M
P
---------------------
D
---------------------
A
VGVP
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
-
P
-
E
-
K
--
F
D
P
R
D
Y
L
G
P
G
-
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
------------
8
PsiBlast_PDB
88.80
34%
-105
- C4 -
2ISV
2
?
A:
[3-311]
----
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
-
G
A
L
K
Y
S
-
D
----
M
I
Y
-
L
K
K
L
-----
C
E
A
A
L
E
K
------
H
P
D
-
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
-------------------
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
---------
R
L
A
I
D
R
V
K
T
I
S
D
L
T
G
-
I
P
L
V
M
H
G
SSSVP
K
D
V
K
D
M
I
N
K
Y
G
G
---------------------
K
M
P
---------------------
D
---------------------
A
VGVP
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
-
P
-
E
-
K
--
F
D
P
R
D
Y
L
G
P
G
-
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
------------
51
HHSearch
88.60
36%
-105
* C4 *
1GVF
11
KBAY_ECOLI
A:
[2-285]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
-
G
T
F
K
H
I
A
L
----
E
E
I
-
Y
A
L
C
-----
S
--
A
Y
S
T
------
T
Y
N
-
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-------------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
K
--
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
V
D
-
V
P
L
V
L
H
G
---------------
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
-
F
A
E
-
N
P
Q
-
G
--
N
D
P
R
Y
Y
M
R
V
G
-
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
---------------
9
PsiBlast_PDB
88.50
34%
-103
- C4 -
2ISW
2
?
A:
[3-311]
----
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
-
G
A
L
K
Y
S
-
D
----
M
I
Y
-
L
K
K
L
-----
C
E
A
A
L
E
K
------
H
P
D
-
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
------------
V
Q
---
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
K
S
----
R
L
A
I
D
R
V
K
T
I
S
D
L
T
G
-
I
P
L
V
M
H
G
SSSVP
K
D
V
K
D
M
I
N
K
Y
G
G
---------------------
K
M
P
---------------------
D
---------------------
A
VGVP
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
-
P
-
E
-
K
--
F
D
P
R
D
Y
L
G
P
G
-
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
------------
4
PsiBlast_PDB
87.51
35%
-100
- C4 -
1GVF
11
KBAY_ECOLI
A:
[3-284]
----
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
-
L
----
E
E
I
-
Y
A
L
C
-----
S
--
A
Y
S
T
------
T
Y
N
-
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-------------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
--
S
K
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
V
D
-
V
P
L
V
L
H
G
---------------
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
-
F
A
E
-
N
-
P
-
Q
--
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
----------------
40
Fugue
87.06
38%
-98
- C4 -
1GVF
11
KBAY_ECOLI
A:
[2-285]
SII
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
-
G
T
F
K
----
H
IA
L
E
E
I
-
Y
A
L
C
-----
S
--
A
Y
S
T
------
T
Y
N
-
M
P
L
A
L
H
L
D
H
H
ES
L
D
D
I
R
R
K
V
H
A
-----------
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
S
-------------
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
-
L
Y
S
-
K
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
V
-D
V
P
L
V
L
H
G
---------------
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
-
F
A
E
-
N
-
P
--QG
N
D
P
R
Y
Y
M
R
V
G
-
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
---------------
28
PsiBlast_CBE
87.03
35%
-95
- C4 -
1GVF
12
KBAY_ECOLI
B:
[3-284]
----
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
-
L
----
E
E
I
-
Y
A
L
C
-----
S
--
A
Y
S
T
------
T
Y
N
-
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
----------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
--
S
K
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
V
D
-
V
P
L
V
L
H
G
---------------
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
-
F
A
E
-
N
-
P
-
Q
--
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
----------------
27
PsiBlast_CBE
86.63
37%
-101
- C4 -
4TO8
2
?
B:
[3-279]
----
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
-
G
A
A
R
Y
M
------
S
G
F
-
Y
T
I
V
K
M
V
E
G
L
--
M
H
D
L
------
N
I
T
-
I
P
V
A
I
H
L
D
H
G
-----------
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
--
V
--
A
D
G
I
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
--------
P
K
L
G
F
--
K
E
M
E
E
I
G
L
S
T
G
-
L
P
L
V
L
H
G
---------------
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
------
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
-
L
N
N
D
K
-
E
-
V
--
Y
D
P
R
K
Y
L
G
P
A
-
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
----------------------
3
PsiBlast_PDB
86.03
37%
-100
- C4 -
4TO8
2
?
A:
[3-279]
----
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
-
G
A
A
R
Y
M
------
S
G
F
-
Y
T
I
V
K
M
V
E
G
L
--
M
H
D
L
------
N
I
T
-
I
P
V
A
I
H
L
D
H
G
-----------
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
--
V
--
A
D
G
I
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
G
-------
P
K
L
G
F
--
K
E
M
E
E
I
G
L
S
T
G
-
L
P
L
V
L
H
G
---------------
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
------
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
-
L
N
N
D
K
-
E
-
V
--
Y
D
P
R
K
Y
L
G
P
A
-
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
----------------------
6
PsiBlast_PDB
85.77
36%
-86
- C4 -
3Q94
10
?
A:
[6-287]
----
L
V
S
M
K
E
M
L
N
K
A
L
E
G
K
Y
A
V
G
Q
F
N
M
N
N
L
E
W
T
Q
A
I
L
A
A
A
E
E
E
K
S
P
V
I
L
G
V
---
S
E
G
A
A
R
-
H
----
M
T
G
-
F
K
T
V
-----
V
--
A
M
V
K
A
L
I
E
E
M
N
I
T
-
V
P
V
A
I
H
L
D
H
G
-----------
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
H
P
F
E
E
N
V
E
T
T
K
K
V
V
E
Y
A
H
A
R
N
V
S
V
E
A
E
L
G
T
V
G
G
Q
E
D
D
V
IA
E
G
----
V
I
Y
A
D
P
A
E
C
K
H
L
V
E
A
T
G
I
D
C
L
A
P
A
L
G
S
V
H
G
--
P
Y
K
G
E
P
N
L
G
F
--
A
E
M
E
Q
V
R
D
F
T
G
-
V
P
L
V
L
H
G
---------------
G
T
---------------------
G
I
P
---------------------
T
---------------------
A
------
D
I
E
K
A
I
S
L
G
T
S
K
I
N
V
N
T
E
N
Q
I
E
F
T
K
A
V
R
E
V
-
L
N
K
D
Q
-
E
-
V
--
Y
D
P
R
K
F
I
G
P
G
-
R
D
A
I
K
A
T
V
I
G
K
I
R
E
F
G
S
N
G
K
-----------------