@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2134: (2016-04-01 )
MYVSMKGMLERANKEHYAVMAINCFNLETARAVIDAAQELRAPIIIDLLQDHLTSHLGSRFLTKPIIKMAEEASVEVAINLDHGHDVAIVKQCLADGFSSVMMDASSFPYEENVAITKKMVEFAEVYHASVEAEVGNIGAVTGDNYTNQEMYTDPKVAIDFAKRTGIDALAISYGSSHGDYPEGFTPAFQFDIVREIKSATNMPLVLHGGSGCGAENIRESVRLGINKINVGSDFMKAQVNQIKTNLKESPAVNYVDLIHETIKAGTKAVKYYIHLSGSTGKSL
Atome Classification :
(27 SA)
---.........10........20........30........40........50..-......60........70------.--.--......80...-.....90........100.......110.......120.......130.......140.......150.........160.......170.......180.......190-........200........---------------------210--------------------........220.......230.----......240.......250----.--.----......260.......270.......280..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MYV
S
M
K
G
M
L
E
RANKE
H
Y
A
V
M
A
I
N
C
F
N
L
E
T
A
R
A
V
I
D
A
A
Q
E
LRA
P
I
I
I
D
L
L
Q
D
H
L
-
T
S
H
L
G
S
R
F
L
T
K
P
I
I
K
M
AE------E--A--
S
V
E
V
A
I
N
LDHG-H
D
V
A
I
V
K
Q
C
L
A
D
G
F
S
S
V
M
M
DASSFPYEE
N
V
A
I
T
K
K
M
V
E
F
A
E
V
Y
H
A
S
V
E
A
EVG
N
I
G
A
VTGDNYTNQE--MYTDP
K
V
A
I
D
FAKRTGI
D
A
L
A
I
SYGSSHGDYPEGFT
P
A
F
Q
F
--
D
I
V
R
E
I
K
SA-TNM
P
L
V
L
HG---------------------GS---------------------GC
G
A
E
N
I
R
E
S
V
R
LGINKINVG
S
----
D
F
M
K
A
Q
V
N
Q
I
K
T
NLKES-P----A--
V
----
N
Y
V
D
L
I
H
E
T
I
K
AGT
K
A
V
K
Y
Y
I
H
L
SGSTGKSL
49
HHSearch
90.23
35%
-88
- C1 -
1RVG
8
?
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
-
Y
G
G
-
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
----
K
D
A
--
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAA
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
----
E
--
F
----
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
23
PsiBlast_CBE
88.78
32%
-93
- C1 -
1RVG
6
?
C:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVPPELVERFRASGGEIGEAA
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
22
PsiBlast_CBE
88.48
32%
-92
- C1 -
1RVG
5
?
D:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVPPELVERFRASGGEIGEAA
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
25
PsiBlast_CBE
88.45
32%
-93
- C1 -
1RV8
6
?
D:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVPPELVERFRASGGEIGEAA
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
24
PsiBlast_CBE
88.11
32%
-95
- C1 -
1RVG
6
?
B:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
26
PsiBlast_CBE
87.99
32%
-92
- C1 -
1RV8
6
?
C:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVPPELVERFRASGGEIGEAA
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
4
PsiBlast_PDB
87.98
32%
-88
- C1 -
1RVG
8
?
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
------
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAA
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
3
PsiBlast_PDB
87.77
32%
-88
- C1 -
1RV8
7
?
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
--------
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAA
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
50
HHSearch
86.82
35%
-85
- C1 -
2ISW
2
?
A:
[2-307]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
-
K
-
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
K
-----
H
--
P
--
D
I
P
I
C
I
H
L
D
H
G
-
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-----------
V
--
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
K
S
--
R
L
A
I
--
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
---------------------
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
----
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
----
K
--
F
----
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
27
PsiBlast_CBE
86.81
32%
-94
- C1 -
1RV8
6
?
B:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
-
K
--
Y
G
G
R
A
L
T
L
M
A
V
E
L
A
K
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
---------------------
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
10
PsiBlast_PDB
86.23
32%
-105
- C1 -
3C4U
2
ALF_HELPY
A:
[1-267]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
--
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
------
R
Y
-
P
--
H
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
---------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
---------------------
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
GGDLKGSK
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
----
D
L
R
I
A
F
I
A
E
V
R
---------------------------------------------------
28
PsiBlast_CBE
85.98
32%
-102
- C1 -
1GVF
12
KBAY_ECOLI
B:
[4-254]
-----
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
--
K
H
I
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
------
T
--
Y
--
N
M
P
L
A
L
H
L
D
H
H
-
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
--------SA
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
K
--
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
L
V
L
H
G
---------------------
A
S
---------------------
D
V
P
D
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
----
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
-
P
----
Q
--
G
----
N
------------------------------
51
HHSearch
85.70
30%
-95
* C1 *
1GVF
11
KBAY_ECOLI
A:
[2-284]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
-
K
-
H
I
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
------
T
--
Y
--
N
M
P
L
A
L
H
L
D
H
H
-
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
---------
S
A
--
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
--
K
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
L
V
L
H
G
---------------------
A
S
---------------------
D
V
P
D
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
----
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
----
G
--
N
----
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-
38
PsiBlast_CBE
85.37
32%
-103
- C1 -
3C4U
2
ALF_HELPY
B:
[1-267]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
--
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
------
R
Y-
P
--
H
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
---------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
---------------------
A
S
AIPDNVRKSYLDAGGDLKGSK
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
----
D
L
R
I
A
F
I
A
E
V
R
---------------------------------------------------
40
Fugue
85.21
30%
-93
- C1 -
1GVF
11
KBAY_ECOLI
A:
[2-285]
SII
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
--
H
I
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
------
T
--
Y
--
N
M
P
L
A
L
H
L
D
H
H
E-
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
S
---------
A
--
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
-
L
Y
S
K
-
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
V-
D
V
P
L
V
L
H
G
---------------------
A
S
---------------------
D
V
P
D
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
----
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
-
P
-----QG
N
----
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
32
PsiBlast_CBE
84.16
32%
-100
- C1 -
3N9R
14
?
Z:
[1-267]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
--
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
------
R
Y-
P
--
H
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
---------A-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
---------------------
A
S
AIPDNVRKSYLDAGGDLKGSK
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
----
D
L
R
I
A
F
I
A
E
V
R
---------------------------------------------------
21
PsiBlast_CBE
83.64
38%
-87
- C1 -
4TO8
2
?
B:
[4-274]
-----
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
---
A
A
R
Y
M
S
G
F
Y
T
--
I
V
K
M
V
E
G
L
M
H
D
L
N
--
I
--
T
I
P
V
A
I
H
L
D
H
G
-
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
G
I
--
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
--------
P
K
L
G
F
--
K
E
M
E
E
I
G
L
S
-
T
G
L
P
L
V
L
H
G
---------------------
G
T
---------------------
G
I
P
T
K
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
----
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
-
K
----
E
--
V
YDPR
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
---------------
34
PsiBlast_CBE
83.59
32%
-102
- C1 -
3N9R
4
?
P:
[1-267]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
--
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
------
R
Y-
P
--
H
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
---------A-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
---------------------
A
S
AIPDNVRKSYLDAGGDLKGSK
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
----
D
L
R
I
A
F
I
A
E
V
R
---------------------------------------------------
33
PsiBlast_CBE
83.41
32%
-99
- C1 -
3N9R
2
?
U:
[1-267]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
--
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
------
R
Y-
P
--
H
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
---------A-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
---------------------
A
S
AIPDNVRKSYLDAGGDLKGSK
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
----
D
L
R
I
A
F
I
A
E
V
R
---------------------------------------------------
5
PsiBlast_PDB
83.41
32%
-104
- C1 -
1GVF
11
KBAY_ECOLI
A:
[4-254]
-----
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
--
K
H
I
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
------
T
--
Y
--
N
M
P
L
A
L
H
L
D
H
H
-
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-----------SA
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
K
--
T
P
K
I
D
F
--
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
L
V
L
H
G
---------------------
A
S
---------------------
D
V
P
D
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
----
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
-
P
----
Q
--
G
----
N
------------------------------
1
PsiBlast_PDB
83.18
38%
-88
- C1 -
4TO8
2
?
A:
[4-274]
-----
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
---
A
A
R
Y
M
S
G
F
Y
T
--
I
V
K
M
V
E
G
L
M
H
D
L
N
--
I
--
T
I
P
V
A
I
H
L
D
H
G
-
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
G
I
--
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
G
-------
P
K
L
G
F
--
K
E
M
E
E
I
G
L
S
-
T
G
L
P
L
V
L
H
G
---------------------
G
T
---------------------
G
I
P
T
K
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
----
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
-
K
----
E
--
V
YDPR
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
---------------
8
PsiBlast_PDB
82.71
33%
-94
- C1 -
2ISW
2
?
A:
[5-274]
------
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
-
K
--
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
------
E
K
H
P
--
D
I
P
I
C
I
H
L
D
H
G
-
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-----------
V
--
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
K
S
----
R
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
---------------------
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
----
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
-
P
-------------------------------------------
7
PsiBlast_PDB
82.66
33%
-104
- C1 -
2ISV
2
?
A:
[5-274]
------
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
-
K
--
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
------
E
K
H
P
--
D
I
P
I
C
I
H
L
D
H
G
-
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
-----------------
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
---------
R
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
---------------------
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
----
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
-
P
-------------------------------------------
11
PsiBlast_PDB
82.31
32%
-97
- C1 -
3C52
4
ALF_HELPY
A:
[1-267]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
--
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
------
R
Y
-
P
--
H
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
-----------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
--
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
---------------------
A
S
AIP
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
GSK
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
----
D
L
R
I
A
F
I
A
E
V
R
---------------------------------------------------
6
PsiBlast_PDB
81.65
32%
-82
- C1 -
2FJK
1
ALF_THECA
A:
[8-305]
----------
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
---
A
M
K
Y
G
G
R
A
L
T
R
M
V
V
A
L
A
Q
------
E
--
A
--
R
V
P
V
A
V
H
L
D
H
G
-
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
DA
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
--
P
R
L
A
R
I
A
K
L
-
V
P
A
P
L
V
L
H
G
ASAVP
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
E
A
S
---------------------
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
----
D
L
R
L
A
F
T
A
L
V
R
E
T
L
G
K
N
-
P
KEFD
P
--
R
----
K
Y
L
G
P
A
R
E
A
V
K
---
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
29
PsiBlast_CBE
80.21
33%
-94
- C1 -
2ISV
2
?
B:
[5-274]
------
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
-
K
--
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
------
E
K
H
P
--
D
I
P
I
C
I
H
L
D
H
G
-
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
----------
Q
N
T
V
--
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
-----
I
R
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
---------------------
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
----
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
-
P
-------------------------------------------
2
PsiBlast_PDB
77.45
37%
-86
- C1 -
3Q94
10
?
A:
[7-246]
-----
V
S
M
K
E
M
L
N
K
A
L
E
G
K
Y
A
V
G
Q
F
N
M
N
N
L
E
W
T
Q
A
I
L
A
A
A
E
E
E
K
S
P
V
I
L
G
V
S
E
G
A
A
-
R
H
M
T
G
F
K
T
V
V
A
M
V
K
A
L
I
E
------
E
--
M
NI
T
V
P
V
A
I
H
L
D
H
G
-
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
H
P
F
E
E
N
V
E
T
T
K
K
V
V
E
Y
A
H
A
R
N
V
S
V
E
A
E
L
G
T
V
G
G
Q
E
D
D
V
I
A
E
G
V
--
I
Y
A
D
P
A
E
C
K
H
L
V
E
A
T
G
I
D
C
L
A
P
A
L
G
S
V
H
G
P
Y
K
--
G
E
P
N
L
G
F
--
A
E
M
E
Q
V
R
D
F
-
T
G
V
P
L
V
L
H
G
---------------------
G
T
---------------------
G
I
P
T
A
D
I
E
K
A
I
S
L
G
T
S
K
I
N
V
N
T
E
N
Q
I
E
F
T
K
A
---------------------------------------------------------