@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2175: (2016-04-01 )
MGKLNGKVAVVTGAASGMGQQIAILFAKEGAKVVVADLNLEAAQKTVELVEKEHGTGLAVVANVTKQEDIENMINQAIEAFGTLDILVNNAGIMDNFVPAGELTDELWDKVFAINTTGVMRATREALHIFEEKGQGVIVNIASAGGLFGSRAGAAYTASKHAVVGFTKNVGFQYANKNIRCNAIAPGAVNTNIGTTIYAPDEFGQERAMIGMGINPRAGDASEIAKVALFLASDDSSFVNGTVITADAGWTAY
Atome Classification :
(30 SA)
.........10........20........30....-....-40......-..50......---.-.60-........70........80........90...-...--..100...---....110.......120.......130..-.....140.......150--.......160.......170.......180.......190....-...-200.......210.......220.......230.......240.......250.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKLN
G
K
V
A
V
V
T
GAASGMG
Q
Q
I
A
I
L
F
AKEG
A
K
V
V
V
-
A
DL
N
-
L
E
A
A
Q
K
T
V
-
E
L
V
E
KEHGT
G
---
L
-
A
V
V
-ANV
T
K
Q
E
D
I
E
N
M
I
N
Q
A
I
E
A
FG
T
L
D
I
L
VNNAGIM-DNF--VP
A
G
E
L
T
D
---
E
L
W
D
K
V
F
A
INT
T
G
V
M
R
A
T
R
E
A
L
H
I
F
E
EKG-
Q
G
V
I
V
N
IASAGGLFGSRA--G
A
A
YTASK
H
A
V
V
G
F
TKNV
G
F
Q
YANK
N
I
R
C
N
AIAPGAVNTNIG
T
T
-
I
YA-PDEFGQE
R
A
M
I
GMGINPRAG
D
A
S
E
I
A
K
V
A
L
F
L
ASDDSSFVN
G
T
V
I
T
ADAGWTAY
7
PsiBlast_PDB
85.09
39%
-94
- C1 -
3AUS
-
DHG4_BACME
A:
[5-253]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
4
PsiBlast_PDB
84.99
39%
-94
- C1 -
3AY6
3
DHG4_BACME
A:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
57
PsiBlast_CBE
84.43
40%
-96
- C1 -
4JRO
1
?
D:
[27-268]
---
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
F
F
N
Y
N
G
S
-
P
E
A
A
E
E
T
A
-
K
L
V
-
A
E
H
G
V
E
---
V
E
A
M
K
-
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
R
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
--
L
M
--
R
M
K
E
---
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
M
K
Q
R
-
A
G
K
I
I
N
M
A
S
V
V
G
L
I
G
N
A
G
--
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
T
T
D
M
T
--------
D
E
K
T
K
E
-
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
S
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
G
----
25
PsiBlast_CBE
84.01
40%
-93
- C1 -
4URE
5
?
B:
[3-247]
---
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
-
S
D
I
S
-
D
E
W
G
R
E
T
L
-
A
L
I
E
G
K
G
G
K
A
---
V
-
F
Q
H
-
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
-
G
E
F
--
T
P
T
A
E
T
T
D
---
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
G
-
G
G
A
I
V
N
I
S
S
I
A
G
Q
I
G
I
E
G
--
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
V
Q
N
-
V
---
P
L
E
--
T
R
R
Q
L
E
Q
M
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
-
3
PsiBlast_PDB
83.06
40%
-93
- C1 -
4URF
9
?
A:
[3-247]
---
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
-
S
D
I
S
-
D
E
W
G
R
E
T
L
-
A
L
I
E
G
K
G
G
K
A
---
V
-
F
Q
H
-
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
-
G
E
F
--
T
P
T
A
E
T
T
D
---
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
G
-
G
G
A
I
V
N
I
S
S
I
A
G
Q
I
G
I
E
G
--
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
V
Q
N
-
V
---
P
L
E
--
T
R
R
Q
L
E
Q
M
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
-
34
PsiBlast_CBE
82.90
39%
-96
- C1 -
3AUT
1
DHG4_BACME
B:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
26
PsiBlast_CBE
82.85
39%
-92
- C1 -
3AY6
3
DHG4_BACME
D:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
9
PsiBlast_PDB
82.84
39%
-93
- C1 -
3AUU
1
DHG4_BACME
A:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
18
PsiBlast_PDB
82.82
40%
-101
- C1 -
4JRO
-
?
A:
[27-268]
---
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
F
F
N
Y
N
G
S
-
P
E
A
A
E
E
T
A
-
K
L
V
-
A
E
H
G
V
E
---
V
E
A
M
K
-
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
R
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
--
L
M
--
R
M
K
E
---
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
M
K
Q
R
-
A
G
K
I
I
N
M
A
S
V
V
G
L
I
G
N
A
G
--
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
T
T
D
M
T
D
K
-
L
----
D
E
K
T
K
E
-
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
S
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
G
----
67
PsiBlast_CBE
82.65
36%
-94
- C1 -
3AWD
2
?
C:
[10-260]
--
R
L
D
N
R
V
A
I
V
T
G
G
A
Q
N
I
G
L
A
C
V
T
A
L
A
E
A
G
A
R
V
I
I
-
A
D
L
D
-
E
A
M
A
T
K
A
V
-
E
D
L
R
M
E
G
H
D
V
---
S
-
S
V
V
-
M
D
V
T
N
T
E
S
V
Q
N
A
V
R
S
V
H
E
Q
E
G
R
V
D
I
L
V
A
C
A
G
I
C
-
I
S
E
--
V
K
A
E
D
M
T
D
---
G
Q
W
L
K
Q
V
D
I
N
L
N
G
M
F
R
S
C
Q
A
V
G
R
I
M
L
E
Q
K
-
Q
G
V
I
V
A
I
G
S
M
S
G
L
I
V
N
R
P
QQ
Q
A
A
Y
N
A
S
K
A
G
V
H
Q
Y
I
R
S
L
A
A
E
W
A
P
H
G
I
R
A
N
A
V
A
P
T
Y
I
E
T
T
L
T
R
F
G
M
E
K
-
P
E
L
Y
D
A
W
I
A
G
T
P
M
G
---
R
V
G
Q
P
D
E
V
A
S
V
V
Q
F
L
A
S
D
A
A
S
L
M
T
G
A
I
V
N
V
D
A
G
F
T
V
W
2
PsiBlast_PDB
82.38
40%
-92
- C1 -
4URE
1
?
A:
[3-247]
---
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
-
S
D
I
S
-
D
E
W
G
R
E
T
L
-
A
L
I
E
G
K
G
G
K
A
---
V
-
F
Q
H
-
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
-
G
E
F
--
T
P
T
A
E
T
T
D
---
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
G
-
G
G
A
I
V
N
I
S
S
I
A
G
Q
I
G
I
E
G
--
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
V
Q
N
-
V
---
P
L
E
--
T
R
R
Q
L
E
Q
M
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
-
68
PsiBlast_CBE
82.36
36%
-93
- C1 -
3AWD
2
?
B:
[10-260]
--
R
L
D
N
R
V
A
I
V
T
G
G
A
Q
N
I
G
L
A
C
V
T
A
L
A
E
A
G
A
R
V
I
I
-
A
D
L
D
-
E
A
M
A
T
K
A
V
-
E
D
L
R
M
E
G
H
D
V
---
S
-
S
V
V
-
M
D
V
T
N
T
E
S
V
Q
N
A
V
R
S
V
H
E
Q
E
G
R
V
D
I
L
V
A
C
A
G
I
C
-
I
S
E
--
V
K
A
E
D
M
T
D
---
G
Q
W
L
K
Q
V
D
I
N
L
N
G
M
F
R
S
C
Q
A
V
G
R
I
M
L
E
Q
K
-
Q
G
V
I
V
A
I
G
S
M
S
G
L
I
V
N
R
P
QQ
Q
A
A
Y
N
A
S
K
A
G
V
H
Q
Y
I
R
S
L
A
A
E
W
A
P
H
G
I
R
A
N
A
V
A
P
T
Y
I
E
T
T
L
T
R
F
G
M
E
K
-
P
E
L
Y
D
A
W
I
A
G
T
P
M
G
---
R
V
G
Q
P
D
E
V
A
S
V
V
Q
F
L
A
S
D
A
A
S
L
M
T
G
A
I
V
N
V
D
A
G
F
T
V
W
29
PsiBlast_CBE
82.30
39%
-95
- C1 -
3AY7
1
DHG4_BACME
B:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
27
PsiBlast_CBE
82.10
39%
-94
- C1 -
3AY6
3
DHG4_BACME
C:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
69
PsiBlast_CBE
82.02
36%
-93
- C1 -
3AWD
1
?
A:
[10-260]
--
R
L
D
N
R
V
A
I
V
T
G
G
A
Q
N
I
G
L
A
C
V
T
A
L
A
E
A
G
A
R
V
I
I
-
A
D
L
D
-
E
A
M
A
T
K
A
V
-
E
D
L
R
M
E
G
H
D
V
---
S
-
S
V
V
-
M
D
V
T
N
T
E
S
V
Q
N
A
V
R
S
V
H
E
Q
E
G
R
V
D
I
L
V
A
C
A
G
I
C
-
I
S
E
--
V
K
A
E
D
M
T
D
---
G
Q
W
L
K
Q
V
D
I
N
L
N
G
M
F
R
S
C
Q
A
V
G
R
I
M
L
E
Q
K
-
Q
G
V
I
V
A
I
G
S
M
S
G
L
I
V
N
R
P
QQ
Q
A
A
Y
N
A
S
K
A
G
V
H
Q
Y
I
R
S
L
A
A
E
W
A
P
H
G
I
R
A
N
A
V
A
P
T
Y
I
E
T
T
L
T
R
F
G
M
E
K
-
P
E
L
Y
D
A
W
I
A
G
T
P
M
G
---
R
V
G
Q
P
D
E
V
A
S
V
V
Q
F
L
A
S
D
A
A
S
L
M
T
G
A
I
V
N
V
D
A
G
F
T
V
W
28
PsiBlast_CBE
82.00
39%
-91
- C1 -
3AY6
3
DHG4_BACME
B:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
8
PsiBlast_PDB
81.85
39%
-92
- C1 -
3AUT
-
DHG4_BACME
A:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
33
PsiBlast_CBE
81.40
39%
-95
- C1 -
3AUU
1
DHG4_BACME
B:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
6
PsiBlast_PDB
81.40
39%
-92
- C1 -
3AY7
-
DHG4_BACME
A:
[13-261]
---
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
-
N
Y
Y
N
N
E
E
E
A
L
D
A
K
-
K
E
V
E
E
A
G
G
Q
A
---
I
-
I
V
Q
-
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
--
E
N
P
--
V
P
S
H
E
L
S
L
---
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
M
I
P
W
P
L
--
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
N
T
P
I
N
A
E
-
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
P
M
G
Y
---
I
G
K
P
E
E
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
K
Y
24
PsiBlast_CBE
81.36
40%
-91
- C1 -
4URF
5
?
B:
[3-247]
---
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
-
S
D
I
S
-
D
E
W
G
R
E
T
L
-
A
L
I
E
G
K
G
G
K
A
---
V
-
F
Q
H
-
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
-
G
E
F
--
T
P
T
A
E
T
T
D
---
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
G
-
G
G
A
I
V
N
I
S
S
I
A
G
Q
I
G
I
E
G
--
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
V
Q
N
-
V
---
P
L
E
--
T
R
R
Q
L
E
Q
M
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
-
59
PsiBlast_CBE
79.13
40%
-98
- C1 -
4JRO
1
?
B:
[27-268]
---
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
F
F
N
Y
N
G
S
-
P
E
A
A
E
E
T
A
-
K
L
V
-
A
E
H
G
V
E
---
V
E
A
M
K
-
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
R
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
--
L
M
--
R
M
K
E
---
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
M
K
Q
R
-
A
G
K
I
I
N
M
A
S
V
V
G
L
I
G
N
A
G
--
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
T
T
D
--------------
K
E
-
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
S
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
G
----
116
HHSearch
77.65
36%
-101
- C1 -
2CFC
2
HCDR_XANP2
A:
[1-250]
----
M
S
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
-
L
D
L
S
-
A
E
T
L
E
E
T
A
R
T
H
W
H
A
-
Y
A
D
K
---
V
-
L
R
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
-
G
N
S
EA
G
V
L
H
T
T
P
V
---
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
G
-
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
--
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
T
Q
W
-
R
L
D
-
Q
P
E
--
L
R
D
Q
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
63
PsiBlast_CBE
77.27
37%
-91
- C1 -
2CFC
2
HCDR_XANP2
D:
[3-249]
------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
-
L
D
L
S
-
A
E
T
L
E
E
T
A
-
R
T
H
W
H
A
Y
A
D
K
V--
L
-
R
V
R
-
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
-
G
N
S
---
E
A
G
V
L
H
T
TPV
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
G
-
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
--
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
--
T
-
Q
W
R
-
L
D
Q
P
E
L
R
D
Q
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
-
64
PsiBlast_CBE
74.85
37%
-92
- C1 -
2CFC
2
HCDR_XANP2
C:
[3-249]
------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
-
L
D
L
S
-
A
E
T
L
E
E
T
A
-
R
T
H
W
H
A
Y
A
D
K
V--
L
-
R
V
R
-
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
-
G
N
S
---
E
A
G
V
L
H
T
TPV
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
G
-
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
--
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
--
T
-
Q
W
R
-
L
D
Q
P
E
L
R
D
Q
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
-
20
PsiBlast_PDB
74.56
37%
-93
- C1 -
2CFC
2
HCDR_XANP2
A:
[3-249]
------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
-
L
D
L
S
-
A
E
T
L
E
E
T
A
-
R
T
H
W
H
A
Y
A
D
K
V
--
L
-
R
V
R
-
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
-
G
N
S
---
E
A
G
V
L
H
T
TP
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
G
-
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
--
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
--
T
-
Q
W
R
-
L
D
Q
P
E
L
R
D
Q
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
-
1
PsiBlast_PDB
73.51
40%
-87
- C1 -
4FN4
3
?
A:
[5-252]
---
L
K
N
K
V
V
I
V
T
G
A
G
S
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
V
A
-
V
E
L
--
L
E
--
D
R
L
N
-
Q
I
V
Q
E
L
R
G
M
G
K
E
V
L
-
G
V
K
-
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
-
D
G
V
--
T
P
V
A
E
V
S
D
---
E
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
S
R
A
V
I
P
I
M
L
K
Q
G
-
K
G
V
I
V
N
T
A
S
I
A
G
I
R
G
G
F
A
--
G
A
P
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
V
L
P
G
T
V
K
T
N
I
G
L
G
-
S
S
K
-
P
S
E
L
G
M
R
T
L
T
K
L
M
S
L
S
S
R
L
A
E
P
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
--
65
PsiBlast_CBE
73.22
37%
-92
- C1 -
2CFC
2
HCDR_XANP2
B:
[3-249]
------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
-
L
D
L
S
-
A
E
T
L
E
E
T
A
-
R
T
H
W
H
A
Y
A
D
K
V--
L
-
R
V
R
-
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
-
G
N
S
---
E
A
G
V
L
H
T
TPV
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
G
-
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
F
P
G
--
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
--
T
-
Q
W
R
-
L
D
Q
P
E
L
R
D
Q
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
-
21
PsiBlast_CBE
72.62
40%
-86
- C1 -
4FN4
4
?
D:
[5-252]
---
L
K
N
K
V
V
I
V
T
G
A
G
S
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
V
A
-
V
E
L
--
L
E
--
D
R
L
N
-
Q
I
V
Q
E
L
R
G
M
G
KEV
L
-
G
V
K
-
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
-
D
G
V
--
T
P
V
A
E
V
S
D
---
E
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
S
R
A
V
I
P
I
M
L
K
Q
G
-
K
G
V
I
V
N
T
A
S
I
A
G
I
R
G
G
F
A
--
G
A
P
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
V
L
P
G
T
V
K
T
N
I
G
L
G
-
S
S
K
-
P
S
E
L
G
M
R
T
L
T
K
L
M
S
L
S
S
R
L
A
E
P
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
--
22
PsiBlast_CBE
71.70
40%
-87
- C1 -
4FN4
3
?
C:
[5-252]
---
L
K
N
K
V
V
I
V
T
G
A
G
S
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
V
A
-
V
E
L
--
L
E
--
D
R
L
N
-
Q
I
V
Q
E
L
R
G
M
G
KEV
L
-
G
V
K
-
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
-
D
G
V
--
T
P
V
A
E
V
S
D
---
E
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
S
R
A
V
I
P
I
M
L
K
Q
G
-
K
G
V
I
V
N
T
A
S
I
A
G
I
R
G
G
F
A
--
G
A
P
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
V
L
P
G
T
V
K
T
N
I
G
L
G
-
S
S
K
-
P
S
E
L
G
M
R
T
L
T
K
L
M
S
L
S
S
R
L
A
E
P
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
--
23
PsiBlast_CBE
71.05
40%
-83
- C1 -
4FN4
2
?
B:
[5-252]
---
L
K
N
K
V
V
I
V
T
G
A
G
S
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
V
A
-
V
E
L
--
L
E
--
D
R
L
N
-
Q
I
V
Q
E
L
R
G
M
G
KEV
L
-
G
V
K
-
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
-
D
G
V
--
T
P
V
A
E
V
S
D
---
E
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
S
R
A
V
I
P
I
M
L
K
Q
G
-
K
G
V
I
V
N
T
A
S
I
A
G
I
R
G
G
F
A
--
G
A
P
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
V
L
P
G
T
V
K
T
N
I
G
L
G
-
S
S
K
-
P
S
E
L
G
M
R
T
L
T
K
L
M
S
L
S
S
R
L
A
E
P
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
--