@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2182: (2016-04-01 )
MEVRDVNFSYNGTDAILKNVSFTIQKNKINTIVGPNGSGKSTLLEILARLLSPNSGDVLLEGKSIFEWKAKEFAQNVAIVHQSNVLPNELMVKELLYFGRLPYKNWRMTRTKEDDLAVERALMQTELTEKAEKFVDSLSGGERQRVFIATALVQDTPILLLDEPTTFLDMYFQLEILELVKRLNQEENLTIVMILHDLNQALMYSDHLIVMKNGEVVAKGEPEELLTTDLIAETYGVVADVLNDANNGKYIVPQRRKEF
Atome Classification :
(58 SA)
----.........10-....--.-....20........30........40........--50........60......----..70.--.-----.--.-.----....80..-......90........100--.--.--.--....110--.--.--.....---------120.-----------......130----.....-----.-------------.--------..140.......150..-----...-------..160.......170.......180---.......190.......200..--.....210.......220....---...230.......240.......250.......-------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----ME
V
R
D
V
N
FSY--N
G
T
D
--
A
-
I
L
KN
V
S
F
T
I
QKN
K
I
N
T
I
VGPNGS
G
K
S
T
L
L
E
I
L
A
R
--LLSPNSG
D
V
L
LEGK
S
I
F
E
----
W
K
A
-
K
--
E
-----
F
--
A
-
Q
----
N
V
A
I
V
H
QS-NVL
P
N
E
L
M
V
K
E
L
L
Y
FGRLP--Y--K--N--WRMTRTK--E--
D
--
D
L
A
V
E
---------
R
A
L
M
-----------
Q
T
E
L
T
E
K
------
A
E
K
F
V
-----
D
-------------S--------LSGGE
R
Q
R
V
F
I
A
T
ALVQ-----DT
P
-------
I
L
L
LDEP
T
T
F
L
D
M
Y
F
Q
L
E
I
L
E
L
V
K
R
---LNQEEN
L
T
I
V
M
I
L
H
D
L
N
Q
A
L
MY--S
D
H
L
I
V
M
KN
G
E
V
V
AKG
E
P
E
E
L
L
---
T
T
D
L
I
A
E
T
Y
G
V
V
A
D
V
LNDANNG
K
Y
IVP
Q
R
RKEF-------------------------------------------------------------------------------------
108
Fugue
86.83
30%
-103
- C1 -
1Z47
1
?
A:
[11-355]
GSMT
I
E
F
V
G
V
E
K
I
Y
--
P
G
G
A
--
R
-
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
--
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
----
L
P
P
-
Q
--
K
----------
R
----
N
V
G
L
V
F
Q
N
-
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
--
K
--
R
--------
V
P
K
D
--
E
--
M
--
D
A
R
V
R
---------
E
L
L
R
-----------
F
M
R
L
E
S
Y
------
A
N
R
F
P
-----
H
-------------
E
--------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-----
R
P
Q
-------
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
---
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
--
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
EKP
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
21
PsiBlast_CBE
85.65
36%
-118
- C1 -
4G1U
1
HMUV_YERPE
D:
[24-245]
-------------------
Q
--
A
-
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
--
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
N
S
----
W
Q
P
-
K
--
A
-----
L
--
A
-
R
----
T
R
A
V
M
R
Q
Y
-
S
E
L
A
F
P
F
S
V
S
E
V
I
Q
M
G
R
A
P
--
Y
--
G
--
G
--------
S
--
Q
--
D
--
R
Q
A
L
Q
---------
Q
V
M
A
-----------
Q
T
D
C
L
A
L
------
A
Q
R
D
Y
-----
R
-------------
V
--------
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
LWQPQ
P
T
P
R------
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
---
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
--
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
---
N
A
E
T
L
T
Q
W
Y
-------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.46
36%
-118
- C1 -
4G1U
1
HMUV_YERPE
C:
[24-245]
-------------------
Q
--
A
-
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
--
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
N
S
----
W
Q
P
-
K
--
A
-----
L
--
A
-
R
----
T
R
A
V
M
R
Q
Y
-
S
E
L
A
F
P
F
S
V
S
E
V
I
Q
M
G
R
A
P
--
Y
--
G
--
G
--------
S
--
Q
--
D
--
R
Q
A
L
Q
---------
Q
V
M
A
-----------
Q
T
D
C
L
A
L
------
A
Q
R
D
Y
-----
R
-------------
V
--------
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQ
P
T
P
R
------
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
---
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
--
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
---
N
A
E
T
L
T
Q
W
Y
-------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.91
31%
-107
- C1 -
4U02
1
?
B:
[12-243]
------------
K
W
--
F
G
P
L
--
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
--
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
----
D
R
A
L
R
--
E
-----
I
--
R
-
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
--
R
--
R
--
W
--
P
R
E
K
--
A
--
E
--
K
K
A
L
E
----------
L
L
E
-----------
R
V
G
I
L
D
Q
------
A
R
K
Y
P
-----
A
-------------
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
---
L
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
---
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-----------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.93
31%
-107
- C1 -
4U02
1
?
A:
[12-243]
------------
K
W
--
F
G
P
L
--
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
--
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
----
D
R
A
L
R
--
E
-----
I
--
R
-
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
--
R
--
R
--
W
--
P
R
E
K
--
A
--
E
--
K
K
A
L
E
----------
L
L
E
-----------
R
V
G
I
L
D
Q
------
A
R
K
Y
P
-----
A
-------------
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
---
L
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
---
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-----------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.93
31%
-104
- C1 -
4U02
1
?
D:
[12-243]
------------
K
W
--
F
G
P
L
--
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
--
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
----
D
R
A
L
R
--
E
-----
I
--
R
-
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
--
R
--
R
--
W
--
P
R
E
K
--
A
--
E
--
K
K
A
L
E
----------
L
L
E
-----------
R
V
G
I
L
D
Q
------
A
R
K
Y
P
-----
A
-------------
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
---
L
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
---
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-----------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
82.82
32%
-111
- C1 -
4FI3
3
BTUD_ECOLI
D:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
C
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
82.81
32%
-109
- C1 -
4DBL
4
BTUD_ECOLI
I:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
N
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.70
33%
-119
- C1 -
4YMW
-
?
J:
[12-224]
-----------------
G
S
L
--
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
--
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
----
G
K
V
-
N
IN
K
-----
V
--
R
-
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
---
A
P
--
V
--
K
--
V
--
K
K
M
N
K
K
E
--
A
--
E
--
E
L
A
V
D
----------
L
L
A
-----------
K
V
G
L
L
D
K
------
K
D
Q
Y
P
-----
I
-------------
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-----
Q
P
E
-------
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.65
31%
-108
- C1 -
4U00
3
?
A:
[12-243]
------------
K
W
--
F
G
P
L
--
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
--
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
----
D
R
A
L
R
--
E
-----
I
--
R
-
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
--
R
--
R
--
W
--
P
R
E
K
--
A
--
E
--
K
K
A
L
E
----------
L
L
E
-----------
R
V
G
I
L
D
Q
------
A
R
K
Y
P
-----
A
-------------
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
---
L
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
---
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-----------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.48
33%
-119
- C1 -
4YMU
2
?
A:
[12-224]
-----------------
G
S
L
--
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
--
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
----
G
K
V
-
N
I
N
K
-----
V
--
R
-
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
---
A
P
--
V
--
K
--
V
--
K
K
M
N
K
K
E
--
A
--
E
--
E
L
A
V
D
----------
L
L
A
-----------
K
V
G
L
L
D
K
------
K
D
Q
Y
P
-----
I
-------------
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-----
Q
P
E
-------
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
82.46
32%
-109
- C1 -
4DBL
4
BTUD_ECOLI
D:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
N
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.40
33%
-119
- C1 -
4YMU
2
?
J:
[12-224]
-----------------
G
S
L
--
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
--
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
----
G
K
V
-
N
IN
K
-----
V
--
R
-
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
---
A
P
--
V
--
K
--
V
--
K
K
M
N
K
K
E
--
A
--
E
--
E
L
A
V
D
----------
L
L
A
-----------
K
V
G
L
L
D
K
------
K
D
Q
Y
P
-----
I
-------------
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-----
Q
P
E
-------
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
82.39
32%
-109
- C1 -
4DBL
4
BTUD_ECOLI
H:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
N
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.22
33%
-119
- C1 -
4YMT
-
?
J:
[12-224]
-----------------
G
S
L
--
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
--
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
----
G
K
V
-
N
IN
K
-----
V
--
R
-
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
---
A
P
--
V
--
K
--
V
--
K
K
M
N
K
K
E
--
A
--
E
--
E
L
A
V
D
----------
L
L
A
-----------
K
V
G
L
L
D
K
------
K
D
Q
Y
P
-----
I
-------------
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-----
Q
P
E
-------
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.49
33%
-120
- C1 -
4YMV
1
?
J:
[12-224]
-----------------
G
S
L
--
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
--
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
----
G
K
V
-
N
IN
K
-----
V
--
R
-
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
---
A
P
--
V
--
K
--
V
--
K
K
M
N
K
K
E
--
A
--
E
--
E
L
A
V
D
----------
L
L
A
-----------
K
V
G
L
L
D
K
------
K
D
Q
Y
P
-----
I
-------------
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-----
Q
P
E
-------
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
81.15
32%
-109
- C1 -
4DBL
4
BTUD_ECOLI
C:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
N
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
81.04
31%
-120
- C1 -
4TQU
-
?
S:
[5-223]
----
V
S
I
Q
N
V
V
K
R
Y
--
D
K
T
---
T
-
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
--
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
N
D
----
L
A
P
-
K
--
D
----------
R
----
D
V
A
M
V
F
Q
N
-
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
--------------
L
R
L
K
R
T
K
--
K
--
S
VI
D
A
A
V
K
---------
T
A
A
D
-----------
I
L
G
L
Q
P
L
------
L
E
R
K
P
-----
S
-------------
D
--------
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
-----
D
P
K
-------
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
---
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
--
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
-------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
80.46
32%
-112
- C1 -
4FI3
3
BTUD_ECOLI
C:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
C
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
80.34
31%
-109
- C1 -
4U02
1
?
C:
[12-243]
------------
K
W
--
F
G
P
L
--
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
--
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
----
D
R
A
L
R
--
E
-----
I
--
R
-
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
--
R
--
R
--
W
--
P
R
E
K
--
A
--
E
--
K
K
A
L
E
----------
L
L
E
-----------
R
V
G
I
L
D
Q
------
A
R
K
Y
P
-----
A
-------------
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
---
L
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
---
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-----------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.04
32%
-112
- C1 -
2OLJ
4
?
A:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TN
L
N
K
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.79
32%
-113
- C1 -
2OLK
1
?
A:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
T
N
L
N
K
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
78.80
32%
-107
- C1 -
4R9U
3
BTUD_ECOLI
D:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
C
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.48
33%
-114
- C1 -
4YMV
1
?
A:
[12-224]
-----------------
G
S
L
--
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
--
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
----
G
K
V
-
N
I
N
K
-----
V
--
R
-
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
---
A
P
--
V
--
K
--
V
--
K
K
M
N
K
K
E
--
A
--
E
--
E
L
A
V
D
----------
L
L
A
-----------
K
V
G
L
L
D
K
------
K
D
Q
Y
P
-----
I
-------------
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-----
Q
P
E
-------
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
77.74
32%
-106
- C1 -
2OLK
1
?
D:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNLNK
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
77.67
32%
-109
- C1 -
2OLK
1
?
C:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNLNK
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
77.10
32%
-104
- C1 -
2OLJ
3
?
B:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNLNK
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
76.55
32%
-110
- C1 -
3C4J
4
?
B:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNLNK
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
76.47
32%
-112
- C1 -
4R9U
3
BTUD_ECOLI
C:
[5-232]
----
M
Q
L
Q
D
V
A
E
S
T
--
R
--------
L
G
P
L
S
G
E
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
--
M
T
S
-
G
K
G
S
I
Q
F
A
G
Q
P
L
E
A
----
W
S
A
-
T
--
K
-----
L
--
A
-
L
----
H
R
A
Y
L
S
Q
Q
-
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
L
---------
H
--
Q
--
H
D
K
T
R
T
E
--
L
L-
N
--
D
V
A
G
A
---------
L
A
L
----------------
D
D
K
------
L
G
R
S
T
-----
N
-------------
Q
--------
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
-----
I
T
P
QANPAGQ
L
L
L
L
D
Q
P
M
C
S
L
D
V
A
Q
Q
S
A
L
D
K
I
L
S
A
---
L
S
Q
Q
-
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
--
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
---
T
P
P
N
L
A
Q
A
Y
G
M
-----------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
76.21
32%
-106
- C1 -
2OLK
2
?
B:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNLNK
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
76.11
32%
-108
- C1 -
3C4J
3
?
A:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TN
L
N
K
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
75.54
31%
-102
- C1 -
2HYD
3
Y1866_STAAM
B:
[340-564]
----
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
E
--
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
--
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
----
F
L
T
-
G
--
S
-----
L
--
R
-
N
----
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-----------------
P
T
A
--
T
--
D
--
E
E
V
V
E
---------
A
A
K
M
ANAHDFIMNLP
Q
G
Y
D
T
E
V
------
G
E
R
G
V
-------------------
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-----
N
P
P
-------
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
---
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
-
T
I
T
H
--
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
---
A
---------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.05
32%
-104
- C1 -
3C41
3
?
J:
[14-226]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNLNK
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
74.72
31%
-102
- C1 -
2HYD
3
Y1866_STAAM
A:
[340-564]
----
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
E
--
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
--
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
----
F
L
T
-
G
--
S
-----
L
--
R
-
N
----
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-----------------
P
T
A
--
T
--
D
--
E
E
V
V
E
---------
A
A
K
M
A
NA
H
D
F
I
M
N
LP
Q
G
Y
D
T
E
V
------
G
E
R
G
V
-------------------
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-----
N
P
P
-------
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
---
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
-
T
I
T
H
--
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
---
A
---------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
74.18
31%
-100
- C1 -
4HLU
3
ECFA1_THEMA
C:
[12-227]
----
I
E
L
N
S
V
S
F
R
Y
--
N
G
-
D
--
Y
-
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
--
L
L
A
A
-
A
G
E
I
F
L
D
G
S
P
---------
A
-
D
--
P
-----
F
LL
R
-
K
----
N
V
G
Y
V
F
Q
N
----
P
S
S
Q
I
I
G
A
------------------------
T
V
--
E
--
E
--
D
V
A
F
S
---------
L
E
I
M
GLD--------
E
S
E
M
R
K
R
------
I
K
K
V
L
-----
E
LVGLSGLAAADPL
N
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
-----
D
T
R
-------
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
---
L
-
K
N
E
G
K
G
I
I
L
V
T
H
E
L
-
E
Y
L
D
D
--
M
D
F
I
L
H
I
S
N
G
T
I
D
F
C
G
S
W
E
E
F
V
-------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
74.18
31%
-101
- C1 -
2ONJ
4
Y1866_STAAM
A:
[340-564]
----
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
E
--
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
--
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
----
F
L
T
-
G
--
S
-----
L
--
R
-
N
----
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-----------------
P
T
A
--
T
--
D
--
E
E
V
V
E
---------
A
A
K
M
A
NAHDFIMNLP
Q
G
Y
D
T
E
V
------
G
E
R
G
V
-------------------
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-----
N
P
P
-------
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
---
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
-
T
I
T
H
--
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
---
A
---------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.77
32%
-107
- C1 -
2Q0H
4
?
A:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TN
L
N
K
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
73.60
31%
-86
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[373-598]
----
L
E
F
K
N
V
H
F
A
Y
--
P
A
R
P
EV
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
--
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
----
L
N
P
-
V
--
W
-----
L
--
R
-
S
----
K
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
--
S
--
S
VT
A
--
E
E
I
Q
R
V
A
--
E
V
A
N
--
A
V
A
F
I
---------
R
N
F
P
-----------
Q
G
F
N
T
V
V
------
G
E
K
G
V
-------------------
L
--------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-----
N
P
K
-------
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
---
L
--
M
D
G
R
T
V
L
V
I
A
H
H
L
S
-
T
I
K
N
--
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
73.25
32%
-104
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[19-226]
------------------------
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
--
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
KNTN
L
P
V
-
R
--
E
----------
R
----
R
L
G
Y
L
V
Q
E
-
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-----
L
--
G
--
N
--
G
K
-
G
R
T
A
--
Q
--
E
--
R
Q
R
I
E
---------
A
M
L
E
-----------
L
T
G
I
S
E
L
------
A
G
R
Y
P
-----
H
-------------
E
--------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-----
D
P
E
-------
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
---
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
--
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
--------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
73.18
32%
-107
- C1 -
3C41
3
?
K:
[14-226]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNLNK
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
73.12
31%
-84
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[342-570]
----
L
E
F
K
N
V
H
F
A
Y
--
P
A
R
P
EV
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
--
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
----
L
N
P
-
V
--
W
-----
L
--
R
-
S
----
K
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
--
S
--
S
VT
A
--
E
E
I
Q
R
V
A
--
E
V
A
N
--
A
V
A
F
I
---------
R
N
F
P
-----------
Q
G
F
N
T
V
V
------
G
E
K
G
V
-------------------
L
--------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-----
N
P
K
-------
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
---
L
--
M
D
G
R
T
V
L
V
I
A
H
R
L
S
-
T
I
K
N
--
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
---
S
---------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
72.68
31%
-102
- C1 -
2ONJ
4
Y1866_STAAM
B:
[340-564]
----
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
E
--
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
--
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
----
F
L
T
-
G
--
S
-----
L
--
R
-
N
----
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-----------------
P
T
A
--
T
--
D
--
E
E
V
V
E
---------
A
A
K
M
ANAHDFIMNLP
Q
G
Y
D
T
E
V
------
G
E
R
G
V
-------------------
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-----
N
P
P
-------
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
---
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
-
T
I
T
H
--
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
---
A
---------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.11
32%
-108
- C1 -
2Q0H
4
?
B:
[35-247]
-----------------
G
S
L
--
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
--
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
-
K
--
D
TNL
N
K
V
--
R
-
E
----
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
--
M
--
K
--
V
--
R
K
W
P
R
E
K
--
A
--
E
--
A
K
A
M
E
----------
L
L
D
-----------
K
V
G
L
K
D
K
------
A
H
A
Y
P
-----
D
-------------
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-------
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
---
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
--
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
71.67
31%
-90
- C1 -
2IXE
4
TAP1_RAT
A:
[17-244]
----
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
N
V
--
Q
-
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
--
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
----
Y
D
H
-
H
--
Y
-----
L
--
H
-
T
----
Q
V
A
A
V
G
Q
------------
E
P
L
L
F
G
R
S
F
--
R
--
E
--
N
I
A
Y
G
L
T
R
T
P
T
M
E
--
E
--
I
T
A
V
A
M
E
S
GA
H
D
F
I
S
G
F
P
-----------
Q
G
Y
D
T
E
V
------
G
E
T
G
------
N
-------------
Q
--------
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
-----
K
P
R
-------
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
---
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
-
E
R
--
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-------------------------------------------------------------------------------------------------------------------------