@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2193: (2016-04-01 )
MEKLLEVKDLNISFHTYAGEVKAIRGVNFDLYKGETLAIVGESGSGKSVTTKSIMRLLPEGNSEIKSGQILFNGMDIAKAHEKQMQKIRGKDIAMIFQDPMTSLNPTMTIGKQISEPLIKHQKISKHEAHKTALRLLQLVGIANAEERIKQYPHQFSGGMRQRVVIAISLACNPQILIADEPTTALDVTIQAQILDLMKDLQKKIDTSIIFITHDLGVVANVADRVAVMYGGKIVEIGTVDEIFYNPQHPYTWGLISSMPTLDTDDEELFVIPGTPPDLLHPPKGDAFAARNKYAMQIDLEEEPPLFKVSDTHYAATWLLHPDAPEVTPPDAVLRRQEQFAELHPGMQAVHAKGVEVE
Atome Classification :
(53 SA)
.........10........20-.........30........40........50......-..60........70........80........90--........-----.100.......110.......120...--...-.----..130.......140.......150-.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330--........340.......350......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
L
L
E
V
K
D
L
N
I
S
F
H
T
YAG
E
--
V
K
A
I
RGV
N
F
D
LYKG
E
T
L
A
I
V
GESGSGKSV
T
T
K
S
I
M
R
L-LPEGNSEIKS
G
Q
I
L
FNGM
D
I
A
K
A
H
E
K
Q
M
Q
K
IRG---K
D
I
A
M
I
FQ-----DPMTSLNP
T
M
T
I
G
K
Q
I
S
E
P
L
I
K
--
H
QK--I
S
K
-
H
----
E
A
H
K
T
A
L
R
L
L
Q
L
VGIA
N
A
E
E
R
I
K
QY-
P
H
Q
FSGGM
R
Q
R
V
V
I
A
I
SLACN
P
Q
I
L
I
ADEPT
T
A
L
D
V
T
I
Q
A
Q
I
L
D
L
M
K
D
L
Q
K
KIDT
S
I
I
F
I
THD
L
G
V
V
A
N
V
A
D
R
V
A
V
M
YG
G
K
I
V
E
I
G
T
V
D
E
IFYNPQHPYT
W
G
L
ISSMPTLDTDDE
E
L
F
V
IPGT
P
P
DLLHPPKGDAFAARN
K
Y
A
M
Q
I
DLEEEPP
L
F
K
V
SDT
H
Y
A
A
T
W
L
LHPDAPEVT
P
P
D
---
A
V
L
R
R
Q
E
Q
F
A
E
LHP
G
M
Q
A
V
HAKGVEVE-
1
PsiBlast_PDB
91.92
40%
-94
- C1 -
4FWI
3
?
B:
[2-321]
-
S
I
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
--
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
-
L
P
P
-
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
---
K
E
I
A
L
V
P
Q
-----
A
A
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
T
V
E
A
--
H
G
V
--
R
W
S
-
H
SELI
E
K
A
S
E
K
L
R
M
V
R
L
----
N
P
E
A
V
L
N
S
Y
-
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
----------
P
I
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
----------------------------------------
12
PsiBlast_PDB
76.60
31%
-114
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.07
33%
-114
- C1 -
4U00
3
?
A:
[3-241]
--
P
I
I
R
I
R
N
L
----
H
K
W
F
G
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
------
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
--
D
R
A
L
R
E
I
R
----
R
E
V
G
M
V
F
Q
-----
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
R
R
--
W
P
R
-
E
----
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.62
33%
-116
- C1 -
4U02
1
?
C:
[1-241]
M
E
P
I
I
R
I
R
N
L
----
H
K
W
F
G
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
------
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
--
D
R
A
L
R
E
I
R
----
R
E
V
G
M
V
F
Q
-----
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
R
R
--
W
P
R
-
E
----
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
75.49
33%
-111
- C1 -
4U02
1
?
B:
[1-241]
M
E
P
I
I
R
I
R
N
L
----
H
K
W
F
G
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
------
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
--
D
R
A
L
R
E
I
R
----
R
E
V
G
M
V
F
Q
-----
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
R
R
--
W
P
R
-
E
----
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.40
31%
-109
- C1 -
3TUI
1
METN_ECOLI
C:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.03
33%
-108
- C1 -
4U02
1
?
A:
[1-241]
M
E
P
I
I
R
I
R
N
L
----
H
K
W
F
G
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
------
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
--
D
R
A
L
R
E
I
R
----
R
E
V
G
M
V
F
Q
-----
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
R
R
--
W
P
R
-
E
----
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
74.31
31%
-105
- C1 -
3TUI
1
METN_ECOLI
G:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
74.23
31%
-107
- C1 -
3TUI
1
METN_ECOLI
D:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
103
HHSearch
74.19
32%
-112
* C1 *
3TUI
1
METN_ECOLI
C:
[23-267]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-
E
R
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
-
R
---
R
Q
I
G
M
I
F
Q
-----
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
--
D
N
---
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
---
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
-------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
74.06
31%
-107
- C1 -
3TUI
1
METN_ECOLI
H:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
122
Fugue
73.87
26%
-89
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
------
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
---
Q
-
I
G
M
I
F
Q
-----
H
F
--
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
--
D
N
T
---
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
---
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--------
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
FGI
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
21
PsiBlast_CBE
73.86
33%
-108
- C1 -
4U02
1
?
D:
[2-241]
-
E
P
I
I
R
I
R
N
L
----
H
K
W
F
G
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
------
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
--
D
R
A
L
R
E
I
R
----
R
E
V
G
M
V
F
Q
-----
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
--
V
R
R
--
W
P
R
-
E
----
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.64
32%
-110
- C1 -
3C4J
4
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
73.63
31%
-110
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.58
32%
-109
- C1 -
2OLK
1
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
73.35
31%
-108
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
73.21
31%
-108
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-271]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
--
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
----
R
Q
I
G
M
I
F
Q
-----
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
--
L
D
N
--
T
P
K
-
D
----
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
---
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
---------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
73.15
32%
-108
- C1 -
2OLK
1
?
C:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.54
32%
-104
- C1 -
2OUK
2
?
D:
[23-262]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.49
32%
-105
- C1 -
2OLK
2
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.46
32%
-107
- C1 -
3C41
3
?
K:
[2-241]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.00
32%
-108
- C1 -
2OLJ
4
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
71.63
32%
-105
- C1 -
2OLK
1
?
D:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.35
32%
-102
- C1 -
3C41
3
?
J:
[2-241]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.23
32%
-102
- C1 -
3C4J
3
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.70
32%
-102
- C1 -
2Q0H
4
?
A:
[23-262]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
70.44
32%
-103
- C1 -
2OLJ
3
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
------
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
----
E
E
V
G
M
V
F
Q
-----
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
--
V
R
K
--
W
P
R
-
E
----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
68.51
34%
-113
- C1 -
4YMU
2
?
A:
[12-239]
------------------
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
------
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-
K
V
N
I
N
K
V
R
Q
---
K
-
V
G
M
V
F
Q
-----
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
--
V
K
K
--
M
N
K
-
K
----
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
---
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.50
34%
-116
- C1 -
4YMV
1
?
J:
[12-239]
------------------
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
------
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-
K
V
N
I
N
K
V
R
Q
---
K
-
V
G
M
V
F
Q
-----
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
--
V
K
K
--
M
N
K
-
K
----
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
---
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.44
34%
-111
- C1 -
4YMU
2
?
J:
[12-239]
------------------
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
------
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-
K
V
N
I
N
K
V
R
Q
---
K
-
V
G
M
V
F
Q
-----
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
--
V
K
K
--
M
N
K
-
K
----
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
---
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.24
34%
-112
- C1 -
4YMV
1
?
A:
[12-239]
------------------
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
------
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-
K
V
N
I
N
K
V
R
Q
---
K
-
V
G
M
V
F
Q
-----
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
--
V
K
K
--
M
N
K
-
K
----
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
---
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
59.25
32%
-95
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
--
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
-
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
-----
D
D
E
L
T
K
I
R
R
---
D
K
I
G
F
V
F
Q
-------
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
F
--
K
Y
R
GA
M
S
G
-
E
----
E
R
R
K
R
A
L
E
C
L
K
M
---
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
59.06
32%
-89
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
--
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
-
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
-----
D
D
E
L
T
K
I
R
R
---
D
K
I
G
F
V
F
Q
-------
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
F
--
K
Y
R
G
A
M
S
G
-
E
----
E
R
R
K
R
A
L
E
C
L
K
M
---
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
57.68
33%
-91
- C1 -
3TIF
7
Y796_METJA
A:
[2-223]
------
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
-
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
-----
D
D
E
L
T
K
I
R
R
---
D
K
I
G
F
V
F
Q
-------
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
F
--
K
Y
R
G
A
M
S
G
-
E
----
E
R
R
K
R
A
L
E
C
L
K
M
---
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.22
33%
-96
- C1 -
3TIF
7
Y796_METJA
B:
[2-223]
------
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
EI
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
-
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
-----
D
D
E
L
T
K
I
R
R
---
D
K
I
G
F
V
F
Q
-------
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
F
--
K
Y
R
GA
M
S
G
-
E
----
E
R
R
K
R
A
L
E
C
L
K
M
---
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
53.95
34%
-82
- C1 -
2FF7
1
A:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
53.37
34%
-85
- C1 -
2PMK
1
A:
[8-236]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
52.89
33%
-83
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
52.73
33%
-86
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
52.58
33%
-84
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[6-234]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
52.39
33%
-82
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[6-234]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
52.07
33%
-84
- C1 -
2FGJ
2
D:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
51.92
33%
-81
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
51.76
33%
-85
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
51.70
33%
-86
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
51.68
33%
-80
- C1 -
2FFA
2
A:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
51.65
33%
-86
- C1 -
1XEF
3
D:
[6-234]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
51.59
33%
-81
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[6-234]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
51.22
33%
-81
- C1 -
3B5J
1
A:
[8-236]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
50.90
33%
-82
- C1 -
2FGK
2
D:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
50.45
33%
-80
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[12-240]
----------
N
I
R
F
R
Y
K
P
D
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
------
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII--
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
--
I
S
E
L
R
----
E
G
Y
N
T
------
I
V
G
E
Q
G
A
----------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
40.43
31%
-75
- C1 -
5DGX
1
?
A:
[21-241]
------
I
K
D
L
S
F
A
F
----
G
E
--
H
K
V
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
-
Y
T
Q
-----
H
E
G
E
I
L
L
D
G
V
D
---
T
R
E
L
T
L
E
N
L
R
----
S
H
L
S
I
V
S
Q
NVHLF
D
D
T
V
Y
N
N
I
A
F
G
---
E
V
S
E
E
E
V
I
---
D
A
--
L
K
R
-
A
----
N
A
Y
E
F
V
Q
E
L
S
D
--
G
I
---
N
T
N
I
G
N
N
-
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
K
S
C
T
T
--
I
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
----------------------------------------------------------------------------------------------------------------------