@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2201: (2016-04-01 )
MDKRRVVVTGVGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVEKYLEKKEARKMDRFTHYAIASAEMAVQDSGLVIDDSNANRVGVWIGSGIGGMETFETQYEIFLNRGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTTVTACATATNSIGDAFKVIERGDADAMITGGAEAPITKMSLAGFTANKALSLNPDPETACRPFDKDRDGFIIGEGAGIVILEEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVDYINAHGTSTPYNDEYETQAIKTVFGEHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRDNIIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFGGHNATLVFKRIED
Atome Classification :
(48 SA)
.........10........20........30........40-------------.........50-------....-------....60......---..70........80........-90.-..-..-..-.100-........110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.--.--.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320....-..--.330.......340.......350.......360.......370--..-.....380.....-.-..390-.........400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDK
R
R
V
V
V
T
GVGAVTPIGNDAE
T
S
W
E
N
A
K
K
G
V
N
G
V
A
K
MTR--------------LNPDDFP
V
K
I
A
-------
A
E
L
K
-------DF
D
V
E
K
Y
L
E
K
K
E
---
A
R
K
M
D
R
F
T
H
Y
A
IAS
A
E
M
A
VQDS-
G
L
V
-
I
D-DS-NA-
N
R
V
--
G
V
W
I
GSGIGG
M
E
T
F
E
T
Q
Y
E
I
F
L
NRGHRRVS
P
F
F
V
P
M
MIPDMGS
G
Q
V
S
I
R
FGAKGINS
T
T
V
T
A
C
A
T
A
T
NSI
G
D
A
F
K
V
I
ERGDAD
A
M
ITGGAEAP
I
T
K
M
S
LAGFTAN
K
A
L
S--L--N--PDPETACRPFDKDRD
G
F
I
IGEGA
G
I
V
I
L
EEYEHAKARG
A
K
I
Y
A
E
I
V
GYGATGD
A
Y
H
I
TAPAPNG
E
G
A
A
R
A
M
K
M
AIDDAGLTPDK
V
D
Y
I
NAHGTSTPYND
E
Y
E
T
Q
A
I
K
T
V
F
G
E
H
A
-
K
K
--
L
AISSTKSMTGHTLGASG
G
I
E
A
I
F
A
L
L
T
IRDN
I
I
A
P
T
I
H
LKNQD--EV-CDLDYVP-NEARE-A-
N
V
N
---
V
V
I
SNSFGFGGH
N
A
T
L
V
F
K
RIED
2
PsiBlast_PDB
92.16
70%
-75
- C2 -
4LS5
5
FABF_BACSU
A:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
23
PsiBlast_CBE
91.67
70%
-73
- C2 -
4LS5
4
FABF_BACSU
B:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
24
PsiBlast_CBE
91.31
70%
-73
- C2 -
4LS6
6
FABF_BACSU
B:
[15-425]
-
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
F
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
22
PsiBlast_CBE
91.24
70%
-73
- C2 -
4LS7
6
FABF_BACSU
B:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
5
PsiBlast_PDB
91.21
70%
-73
- C2 -
4LS6
4
FABF_BACSU
A:
[16-425]
--
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
F
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
4
PsiBlast_PDB
90.84
70%
-73
- C2 -
4LS8
9
FABF_BACSU
A:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
21
PsiBlast_CBE
90.79
70%
-74
- C2 -
4LS8
5
FABF_BACSU
B:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
3
PsiBlast_PDB
90.32
70%
-73
- C2 -
4LS7
6
FABF_BACSU
A:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
--------------
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
---
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
L
N
-
I
T
-
D
E
-
I
A
-
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
--
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
--
E
E
-
C
D
L
D
Y
V
P
-
D
E
A
R
R
-
Q
-
E
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
6
PsiBlast_PDB
88.80
64%
-73
- C2 -
2GQD
-
FABF_STAAC (first)
A:
[5-413]
---
K
R
V
V
I
T
G
M
G
A
L
S
P
I
G
N
D
V
K
T
T
W
E
N
A
L
K
G
V
N
G
I
D
K
I
T
R
--------------
I
D
T
E
P
Y
S
V
H
L
A
-------
G
E
L
K
-------
N
F
N
I
E
D
H
I
D
K
K
E
---
A
R
R
M
D
R
F
T
Q
Y
A
I
V
A
A
R
E
A
V
K
D
A
-
Q
L
D
-
I
N
-
E
N
-
T
A
-
D
R
I
--
G
V
W
I
G
S
G
I
G
G
M
E
T
F
E
I
A
H
K
Q
L
M
D
K
G
P
R
R
V
S
P
F
F
V
P
M
L
I
P
D
M
A
T
G
Q
V
S
I
D
L
G
A
K
G
P
N
G
A
T
V
T
A
C
A
T
G
T
N
S
I
G
E
A
F
K
I
V
Q
R
G
D
A
D
A
M
I
T
G
G
T
E
A
P
I
T
H
M
A
I
A
G
F
S
A
S
R
A
L
S
--
T
--
N
--
D
D
I
E
T
A
C
R
P
F
Q
E
G
R
D
G
F
V
M
G
E
G
A
G
I
L
V
I
E
S
L
E
S
A
Q
A
R
G
A
N
I
Y
A
E
I
V
G
Y
G
T
T
G
D
A
Y
H
I
T
A
P
A
P
E
G
E
G
G
S
R
A
M
Q
A
A
M
D
D
A
G
I
E
P
K
D
V
Q
Y
L
N
A
H
G
T
S
T
P
V
G
D
L
N
E
V
K
A
I
K
N
T
F
G
E
A
A
-
K
H
--
L
K
V
S
S
T
K
S
M
T
G
H
L
L
G
A
T
G
G
I
E
A
I
F
S
A
L
S
I
K
D
S
K
V
A
P
T
I
H
A
V
T
P
D
--
P
E
-
C
D
L
D
I
V
P
-
N
E
A
Q
D
-
L
-
D
I
T
---
Y
A
M
S
N
S
L
G
F
G
G
H
N
A
V
L
V
F
K
K
F
E
-
120
HHSearch
88.75
64%
-73
- C2 -
2GQD
-
FABF_STAAC (first)
A:
[4-413]
--
N
K
R
V
V
I
T
G
M
G
A
L
S
P
I
G
N
D
V
K
T
T
W
E
N
A
L
K
G
V
N
G
I
D
K
I
T
R
--------------
I
D
T
E
P
Y
S
V
H
L
A
-------
G
E
L
K
-------
N
F
N
I
E
D
H
I
D
K
K
E
---
A
R
R
M
D
R
F
T
Q
Y
A
I
V
A
A
R
E
A
V
K
D
A
-
Q
L
D
-
I
N
-
E
N
-
T
A
-
D
R
I
--
G
V
W
I
G
S
G
I
G
G
M
E
T
F
E
I
A
H
K
Q
L
M
D
K
G
P
R
R
V
S
P
F
F
V
P
M
L
I
P
D
M
A
T
G
Q
V
S
I
D
L
G
A
K
G
P
N
G
A
T
V
T
A
C
A
T
G
T
N
S
I
G
E
A
F
K
I
V
Q
R
G
D
A
D
A
M
I
T
G
G
T
E
A
P
I
T
H
M
A
I
A
G
F
S
A
S
R
A
L
S
--
T
--
N
--
D
D
I
E
T
A
C
R
P
F
Q
E
G
R
D
G
F
V
M
G
E
G
A
G
I
L
V
I
E
S
L
E
S
A
Q
A
R
G
A
N
I
Y
A
E
I
V
G
Y
G
T
T
G
D
A
Y
H
I
T
A
P
A
P
E
G
E
G
G
S
R
A
M
Q
A
A
M
D
D
A
G
I
E
P
K
D
V
Q
Y
L
N
A
H
G
T
S
T
P
V
G
D
L
N
E
V
K
A
I
K
N
T
F
G
E
A
A
-
K
H
--
L
K
V
S
S
T
K
S
M
T
G
H
L
L
G
A
T
G
G
I
E
A
I
F
S
A
L
S
I
K
D
S
K
V
A
P
T
I
H
A
V
T
P
D
--
P
E
-
C
D
L
D
I
V
P
-
N
E
A
Q
D
-
L
-
D
I
T
---
Y
A
M
S
N
S
L
G
F
G
G
H
N
A
V
L
V
F
K
K
F
E
-
114
HHSearch
85.98
56%
-71
- C2 -
1E5M
-
FABF_SYNY3
A:
[6-415]
--
K
K
R
V
V
V
T
G
L
G
A
I
T
P
I
G
N
T
L
Q
D
Y
W
Q
G
L
M
E
G
R
N
G
I
G
P
I
T
R
--------------
F
D
A
S
D
Q
A
C
R
F
G
-------
G
E
V
K
-------
D
F
D
A
T
Q
F
L
D
R
K
E
---
A
K
R
M
D
R
F
C
H
F
A
V
C
A
S
Q
Q
A
I
N
D
A
-
K
L
V
-
I
N
-
E
L
-
N
A
-
D
E
I
--
G
V
L
I
G
T
G
I
G
G
L
K
V
L
E
D
Q
Q
T
I
L
L
D
K
G
P
S
R
C
S
P
F
M
I
P
M
M
I
A
N
M
A
S
G
L
T
A
I
N
L
G
A
K
G
P
N
N
C
T
V
T
A
C
A
A
G
S
N
A
I
G
D
A
F
R
L
V
Q
N
G
Y
A
K
A
M
I
C
G
G
T
E
A
A
I
T
P
L
S
Y
A
G
F
A
S
A
R
A
L
S
--
F
R-
N
--
D
D
P
L
H
A
S
R
P
F
D
K
D
R
D
G
F
V
M
G
E
G
S
G
I
L
I
L
E
E
L
E
S
A
L
A
R
G
A
K
I
Y
G
E
M
V
G
Y
A
M
T
C
D
A
Y
H
I
T
A
P
V
P
D
G
R
G
A
T
R
A
I
A
W
A
L
K
D
S
G
L
K
P
E
M
V
S
Y
I
N
A
H
G
T
S
T
P
A
N
D
V
T
E
T
R
A
I
K
Q
A
L
G
N
H
A
-
Y
N
--
I
A
V
S
S
T
K
S
M
T
G
H
L
L
G
G
S
G
G
I
E
A
V
A
T
V
M
A
I
A
E
D
K
V
P
P
T
I
N
L
E
N
P
D
--
P
E
-
C
D
L
D
Y
V
P
-
G
Q
S
R
A
-
L
-
I
V
D
---
V
A
L
S
N
S
F
G
F
G
G
H
N
V
T
L
A
F
K
K
Y
--
11
PsiBlast_PDB
85.82
51%
-71
- C2 -
4JPF
3
?
A:
[25-435]
--
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
--------------
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
---
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
L
E
-
V
T
-
D
A
-
N
R
-
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
L
V
A
-
H
E
A
K
P
-
R
-
K
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-
7
PsiBlast_PDB
85.59
55%
-71
- C2 -
1E5M
-
FABF_SYNY3
A:
[6-416]
--
K
K
R
V
V
V
T
G
L
G
A
I
T
P
I
G
N
T
L
Q
D
Y
W
Q
G
L
M
E
G
R
N
G
I
G
P
I
T
R
--------------
F
D
A
S
D
Q
A
C
R
F
G
-------
G
E
V
K
-------
D
F
D
A
T
Q
F
L
D
R
K
E
---
A
K
R
M
D
R
F
C
H
F
A
V
C
A
S
Q
Q
A
I
N
D
A
-
K
L
V
-
I
N
-
E
L
-
N
A
-
D
E
I
--
G
V
L
I
G
T
G
I
G
G
L
K
V
L
E
D
Q
Q
T
I
L
L
D
K
G
P
S
R
C
S
P
F
M
I
P
M
M
I
A
N
M
A
S
G
L
T
A
I
N
L
G
A
K
G
P
N
N
C
T
V
T
A
C
A
A
G
S
N
A
I
G
D
A
F
R
L
V
Q
N
G
Y
A
K
A
M
I
C
G
G
T
E
A
A
I
T
P
L
S
Y
A
G
F
A
S
A
R
A
L
S
--
F
R-
N
--
D
D
P
L
H
A
S
R
P
F
D
K
D
R
D
G
F
V
M
G
E
G
S
G
I
L
I
L
E
E
L
E
S
A
L
A
R
G
A
K
I
Y
G
E
M
V
G
Y
A
M
T
C
D
A
Y
H
I
T
A
P
V
P
D
G
R
G
A
T
R
A
I
A
W
A
L
K
D
S
G
L
K
P
E
M
V
S
Y
I
N
A
H
G
T
S
T
P
A
N
D
V
T
E
T
R
A
I
K
Q
A
L
G
N
H
A
-
Y
N
--
I
A
V
S
S
T
K
S
M
T
G
H
L
L
G
G
S
G
G
I
E
A
V
A
T
V
M
A
I
A
E
D
K
V
P
P
T
I
N
L
E
N
P
D
--
P
E
-
C
D
L
D
Y
V
P
-
G
Q
S
R
A
-
L
-
I
V
D
---
V
A
L
S
N
S
F
G
F
G
G
H
N
V
T
L
A
F
K
K
Y
Q
-
27
PsiBlast_CBE
85.35
51%
-70
- C2 -
4B7V
1
?
B:
[26-435]
---
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
--------------
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
---
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
L
E
-
V
T
-
D
A
-
N
R
-
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
L
V
A
-
H
E
A
K
P
-
R
-
K
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-
9
PsiBlast_PDB
85.32
52%
-70
- C2 -
4QAV
3
?
A:
[3-414]
--
Q
R
R
V
V
I
T
G
L
G
Q
V
S
P
V
G
N
T
V
A
E
A
W
D
T
L
L
A
G
K
S
G
I
G
A
I
T
R
--------------
F
D
A
S
D
I
N
S
R
V
A
-------
G
E
V
R
-------
G
F
D
I
G
Q
Y
I
S
A
K
E
---
A
R
R
M
D
V
F
I
H
Y
G
I
A
A
A
L
Q
A
I
A
D
S
-
G
L
D
D
V
E
-
N
L
-
D
K
-
D
R
I
--
G
V
N
I
G
S
G
I
G
G
L
P
S
I
E
V
T
G
K
A
V
I
E
G
G
A
R
K
I
N
P
F
F
I
P
G
S
L
I
N
L
I
S
G
H
V
T
I
L
K
G
Y
R
G
P
S
Y
G
M
V
S
A
C
T
T
G
A
H
A
I
G
N
S
A
R
L
I
K
Y
G
D
A
D
I
M
V
A
G
G
A
E
G
A
I
S
T
L
G
V
G
G
F
A
A
M
K
A
L
S
--
T
R-
N
--
D
D
P
A
T
A
S
R
P
W
D
K
G
R
D
G
F
V
I
G
E
G
A
G
I
L
V
L
E
E
L
E
H
A
K
K
R
G
A
K
I
Y
A
E
I
V
G
F
G
M
S
S
D
A
Y
H
I
T
A
P
--
N
E
E
G
P
A
L
A
V
T
R
A
L
K
D
A
G
I
N
P
E
D
V
D
Y
V
N
A
H
G
T
S
T
P
L
G
D
A
N
E
T
K
A
L
K
R
A
F
G
E
H
A
-
Y
K
--
T
V
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
V
E
A
V
Y
S
I
L
A
I
H
D
G
K
I
P
P
T
I
N
I
F
E
Q
D
VE
A
G
-
C
D
L
D
Y
C
A
-
N
E
A
R
D
-
A
-
E
I
D
---
V
A
I
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
K
R
F
K
-
30
PsiBlast_CBE
84.84
50%
-72
- C2 -
4JRH
2
FABF_VIBCH
B:
[5-417]
-
S
K
R
R
V
V
V
T
G
M
G
M
L
S
P
V
G
N
T
V
E
S
S
W
K
A
L
L
A
G
Q
S
G
I
V
N
I
E
H
--------------
F
D
T
T
N
F
S
T
R
F
A
-------
G
L
V
K
-------
G
F
D
C
E
Q
Y
M
S
K
K
D
---
A
R
K
M
D
L
F
I
Q
Y
G
I
A
A
G
I
Q
A
L
E
D
S
-
G
L
E
-
V
N
-
E
E
-
N
A
-
A
R
I
--
G
V
A
I
G
S
G
I
G
G
L
E
L
I
E
T
G
H
Q
A
L
I
E
K
G
P
R
K
V
S
P
F
F
V
P
S
T
I
V
N
M
I
A
G
N
L
S
I
M
R
G
L
R
G
P
N
I
A
I
S
T
A
C
T
T
G
L
H
N
I
G
H
A
A
R
M
I
A
Y
G
D
A
D
A
M
V
A
G
G
A
E
K
A
S
T
P
L
G
M
A
G
F
G
A
A
K
A
L
S
--
T
R-
N
--
D
E
P
Q
K
A
S
R
P
W
D
K
D
R
D
G
F
V
L
G
D
G
A
G
I
M
V
L
E
E
Y
E
H
A
K
A
R
G
A
K
I
Y
A
E
V
V
G
F
G
M
S
G
D
A
Y
H
M
T
S
P
S
E
D
G
S
G
G
A
L
A
M
E
A
A
M
R
D
A
G
V
T
G
E
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
V
A
E
V
K
G
I
K
R
A
L
G
E
A
G
T
K
Q
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
S
V
E
A
I
I
T
V
M
S
L
V
D
Q
M
V
P
P
T
I
N
L
D
N
P
E
--
E
G
-
L
G
V
D
L
V
P
-
H
V
A
R
K
-
V
E
S
M
E
---
Y
A
M
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
R
M
--
14
PsiBlast_PDB
84.82
51%
-67
- C2 -
4JB6
1
?
A:
[2-413]
-
S
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
--------------
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
---
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
L
E
-
V
T
-
D
A
-
N
R
-
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
Q
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
L
V
A
-
H
E
A
K
P
-
R
-
K
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-
10
PsiBlast_PDB
84.79
51%
-68
- C2 -
4B7V
1
?
A:
[24-435]
-
S
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
--------------
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
---
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
L
E
-
V
T
-
D
A
-
N
R
-
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
L
V
A
-
H
E
A
K
P
-
R
-
K
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-
8
PsiBlast_PDB
84.47
53%
-70
- C2 -
1J3N
1
?
A:
[2-408]
---
R
R
V
V
V
T
G
L
G
A
L
T
P
I
G
V
G
Q
E
A
F
H
K
A
Q
L
A
G
K
S
G
V
R
P
I
T
R
--------------
F
D
A
S
A
L
P
V
R
I
A
-------
A
E
V
--------
D
V
D
P
G
A
Y
L
D
R
K
E
---
L
R
R
L
D
R
F
V
Q
Y
A
L
I
A
A
Q
L
A
L
E
D
A
-
G
L
K
-
P
E
-
D
L
-
D
P
-
E
R
V
--
G
T
L
V
G
T
G
I
G
G
M
E
T
W
E
A
Q
S
R
V
F
L
E
R
G
P
N
R
I
S
P
F
F
I
P
M
M
I
A
N
M
A
S
A
H
I
A
M
R
Y
G
F
T
G
P
S
S
T
V
V
T
A
C
A
T
G
A
D
A
L
G
S
A
L
R
M
I
Q
L
G
E
A
D
L
V
L
A
G
G
T
E
A
A
I
T
P
M
A
I
G
A
F
A
V
M
R
A
L
S
--
T
R-
N
--
E
E
P
E
K
A
S
R
P
F
T
L
S
R
D
G
F
V
M
G
E
G
A
G
V
L
V
L
E
A
Y
E
H
A
K
K
R
G
A
R
I
Y
A
E
L
V
G
F
G
R
S
A
D
A
H
H
I
T
E
P
H
P
E
G
K
G
A
A
L
A
M
A
R
A
L
K
D
A
G
I
A
P
E
Q
V
G
Y
I
N
A
H
G
T
S
T
P
V
G
D
R
A
E
V
L
A
I
K
R
V
F
G
D
H
A
-
K
R
--
L
M
V
S
S
T
K
S
M
I
G
H
L
L
G
A
A
G
A
V
E
A
I
A
T
V
Q
A
L
Y
H
G
V
I
P
P
T
I
N
L
E
D
P
D
--
P
E
-
L
D
L
D
F
V
P
--
E
P
R
E
-
A
-
K
V
D
---
Y
A
L
S
N
S
F
A
F
G
G
H
N
A
V
L
A
F
K
R
V
--
38
PsiBlast_CBE
84.44
47%
-73
- C2 -
4JGA
3
?
A:
[16-434]
---
K
R
V
V
I
T
G
L
G
L
V
T
P
V
G
L
N
V
N
S
S
W
K
N
I
V
D
G
V
S
G
I
K
T
I
T
E
--------------
F
D
T
S
K
L
A
C
K
I
A
GLIDN--
S
E
K
D
-------
G
F
K
L
E
N
F
T
Q
A
D
D
I
N
R
L
S
K
M
D
K
F
I
H
Y
G
V
A
A
A
T
E
A
V
E
D
S
-
G
W
L
-
P
D
-
D
E
-
K
S
R
D
R
T
--
G
L
I
L
G
S
G
I
G
G
L
K
M
I
E
D
T
S
I
K
L
Y
Q
E
N
N
G
K
V
S
P
F
F
I
P
A
S
L
I
N
L
L
S
G
L
V
S
I
K
Y
G
F
S
G
P
N
Q
T
A
V
T
A
C
S
T
G
A
H
A
I
G
D
A
M
R
M
I
K
H
G
Y
A
D
V
M
I
A
G
G
A
E
A
P
V
T
P
V
G
V
A
G
F
V
A
A
R
A
L
C
TK
Y
--
N
--
D
N
P
K
K
A
S
R
P
W
D
K
D
R
S
G
F
V
M
G
E
G
A
G
V
V
V
L
E
E
Y
E
H
A
L
N
R
G
A
K
V
Y
G
E
V
I
G
Y
G
S
T
G
D
A
Y
H
M
T
A
P
H
P
E
G
R
G
A
Y
R
A
M
R
D
A
M
L
D
A
T
I
T
P
D
M
I
D
Y
I
N
A
H
G
T
S
T
T
L
G
D
G
I
E
L
A
A
V
Q
K
L
F
L
E
A
N
-
P
K
--
V
L
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
S
V
E
F
I
F
S
A
L
A
I
R
D
Q
I
A
P
P
T
L
N
L
D
T
P
M
--
D
E
-
V
N
I
D
L
V
A
-
L
K
A
K
K
-
T
-
K
I
D
---
Y
V
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
I
K
S
I
--
37
PsiBlast_CBE
84.29
47%
-72
- C2 -
4JGA
2
?
B:
[16-434]
---
K
R
V
V
I
T
G
L
G
L
V
T
P
V
G
L
N
V
N
S
S
W
K
N
I
V
D
G
V
S
G
I
K
T
I
T
E
--------------
F
D
T
S
K
L
A
C
K
I
A
GLIDN--
S
E
K
D
-------
G
F
K
L
E
N
F
T
Q
A
D
D
INR
L
S
K
M
D
K
F
I
H
Y
G
V
A
A
A
T
E
A
V
E
D
S
-
G
W
L
-
P
D
-
D
E
-
K
S
R
D
R
T
--
G
L
I
L
G
S
G
I
G
G
L
K
M
I
E
D
T
S
I
K
L
Y
Q
E
N
N
G
K
V
S
P
F
F
I
P
A
S
L
I
N
L
L
S
G
L
V
S
I
K
Y
G
F
S
G
P
N
Q
T
A
V
T
A
C
S
T
G
A
H
A
I
G
D
A
M
R
M
I
K
H
G
Y
A
D
V
M
I
A
G
G
A
E
A
P
V
T
P
V
G
V
A
G
F
V
A
A
R
A
L
C
TK
Y
--
N
--
D
N
P
K
K
A
S
R
P
W
D
K
D
R
S
G
F
V
M
G
E
G
A
G
V
V
V
L
E
E
Y
E
H
A
L
N
R
G
A
K
V
Y
G
E
V
I
G
Y
G
S
T
G
D
A
Y
H
M
T
A
P
H
P
E
G
R
G
A
Y
R
A
M
R
D
A
M
L
D
A
T
I
T
P
D
M
I
D
Y
I
N
A
H
G
T
S
T
T
L
G
D
G
I
E
L
A
A
V
Q
K
L
F
L
E
A
N
-
P
K
--
V
L
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
S
V
E
F
I
F
S
A
L
A
I
R
D
Q
I
A
P
P
T
L
N
L
D
T
P
M
--
D
E
-
V
N
I
D
L
V
A
-
L
K
A
K
K
-
T
-
K
I
D
---
Y
V
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
I
K
S
I
--
51
PsiBlast_CBE
83.91
49%
-67
- C2 -
3KZU
2
?
A:
[10-425]
---
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
R
V
T
E
--------------
F
E
V
D
D
L
A
C
Q
I
A
-------
C
R
I
P
VGDGTNG
T
F
N
P
D
L
H
M
D
P
K
E
---
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
-
G
W
H
-
P
E
N
D
E
-
D
Q
-
V
R
T
--
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
--
T
ER
N
--
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
-
M
A
D
T
I
E
L
G
A
V
E
R
V
V
G
E
A
A
-
A
K
--
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
--
A
Q
-
T
R
I
D
L
V
P
-
H
K
P
R
E
-
R
-
K
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
---
116
HHSearch
83.40
50%
-68
- C2 -
3KZU
2
?
A:
[9-427]
--
M
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
R
V
T
E
--------------
F
E
V
D
D
L
A
C
Q
I
A
CRIPVGD
G
T
N
G
-------
T
F
N
P
D
L
H
M
D
P
K
E
---
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
-
G
W
H
-
P
E
-
N
D
E
D
Q
-
V
R
T
--
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
--
T
--
E
RN
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
M
-
A
D
T
I
E
L
G
A
V
E
R
V
V
G
E
A
A
-
A
K
--
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
--
A
Q
-
T
R
I
D
L
V
P
-
H
K
P
R
E
-
R
-
K
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
T
-
50
PsiBlast_CBE
82.02
49%
-66
- C2 -
3KZU
4
?
B:
[10-425]
---
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
R
V
T
E
--------------
F
E
V
D
D
L
A
C
Q
I
A
-------
C
R
I
P
VGDGTNG
T
F
N
P
D
L
H
M
D
P
K
E
---
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
-
G
W
H
-
P
E
N
D
E
-
D
Q
-
V
R
T
--
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
--
T
ER
N
--
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
-
M
A
D
T
I
E
L
G
A
V
E
R
V
V
G
E
A
A
-
A
K
--
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
--
A
Q
-
T
R
I
D
L
V
P
-
H
K
P
R
E
-
R
-
K
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
---
34
PsiBlast_CBE
81.27
49%
-67
- C2 -
3G11
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
33
PsiBlast_CBE
81.12
49%
-69
- C2 -
3HO9
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
20
PsiBlast_PDB
81.12
49%
-68
- C2 -
3HO2
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
52
PsiBlast_CBE
81.06
44%
-66
- C2 -
2IX4
3
KASM_ARATH
B:
[1-431]
---
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
R
G
L
T
L
DDLKMKSFDEETKL
Y
T
F
D
Q
L
S
S
K
V
A
-------
A
F
V
P
YGSNPG-
E
F
D
E
A
L
W
L
N
S
K
------
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
L
P
-
T
E
-
E
E
-
E
K
-
E
R
T
--
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
TK
F
--
N
--
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
Q
S
G
L
C
P
N
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
E
H
A
-
T
S
GT
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
--
P
I
-
F
D
K
R
F
M
P
L
T
T
S
K
K
-
M
-
L
V
R
---
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
A
S
I
--
16
PsiBlast_PDB
81.01
49%
-68
- C2 -
1B3N
1
FABF_ECOLI
A:
[2-412]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
32
PsiBlast_CBE
80.77
49%
-69
- C2 -
3I8P
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
45
PsiBlast_CBE
80.49
45%
-68
- C2 -
2IWZ
3
OXSM_HUMAN
B:
[21-435]
---
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
I
V
S
L
V
G
--------------
E
E
Y
K
S
I
P
C
S
V
A
-------
A
Y
V
P
RGSDEG-
Q
F
N
E
Q
N
F
V
S
K
S
D
---
I
K
S
M
S
S
P
T
I
M
A
I
G
A
A
E
L
A
M
K
D
S
-
G
W
H
--
P
-
Q
S
-
E
A
-
D
Q
V
AT
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
--
T
--
N
--
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
P
D
P
E
G
E
G
A
L
R
C
M
A
A
A
L
K
D
A
G
V
Q
P
E
E
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
D
H
A
-
Y
A
--
L
A
V
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
L
D
C
S
E
--
P
E
-
F
D
L
N
Y
V
P
-
L
K
A
Q
E
-
W
-
K
T
E
KRF
I
G
L
T
N
S
F
G
F
G
G
T
N
A
T
L
C
I
-----
46
PsiBlast_CBE
80.38
45%
-67
- C2 -
2IWZ
3
OXSM_HUMAN
A:
[21-435]
---
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
I
V
S
L
V
G
--------------
E
E
Y
K
S
I
P
C
S
V
A
-------
A
Y
V
P
RGSDEG-
Q
F
N
E
Q
N
F
V
S
K
S
D
---
I
K
S
M
S
S
P
T
I
M
A
I
G
A
A
E
L
A
M
K
D
S
-
G
W
H
--
P
-
Q
S
-
E
A
-
D
Q
V
A
T
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
--
T
--
N
--
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
P
D
P
E
G
E
G
A
L
R
C
M
A
A
A
L
K
D
A
G
V
Q
P
E
E
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
D
H
A
-
Y
A
--
L
A
V
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
L
D
C
S
E
--
P
E
-
F
D
L
N
Y
V
P
-
L
K
A
Q
E
-
W
-
K
T
E
K
R
F
I
G
L
T
N
S
F
G
F
G
G
T
N
A
T
L
C
I
-----
35
PsiBlast_CBE
80.26
49%
-66
- C2 -
3G0Y
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
19
PsiBlast_PDB
80.11
49%
-65
- C2 -
3HNZ
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
36
PsiBlast_CBE
79.84
49%
-65
- C2 -
2GFX
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
53
PsiBlast_CBE
79.82
44%
-65
- C2 -
2IX4
3
KASM_ARATH
A:
[1-431]
---
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
R
G
L
T
L
DDLKMKSFD
E
E
T
K
L
Y
T
F
D
Q
L
S
S
K
V
A
-------
A
F
V
P
YGSNPG-
E
F
D
E
A
L
W
L
N
S
K
------
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
L
P
-
T
E
-
E
E
-
E
K
-
E
R
T
--
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
TK
F
--
N
--
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
Q
S
G
L
C
P
N
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
E
H
A
-
T
S
GT
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
--
P
I
-
F
D
K
R
F
M
P
L
T
T
S
K
K
-
M
-
L
V
R
---
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
A
S
I
--
18
PsiBlast_PDB
79.75
49%
-66
- C2 -
2GFY
1
FABF_ECOLI
A:
[17-427]
--
K
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
L
I
D
H
--------------
F
D
T
S
A
Y
A
T
K
F
A
-------
G
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
---
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
L
E
-
I
T
-
E
E
-
N
A
-
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
--
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
A
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
--
E
G
-
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
-
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
66
PsiBlast_CBE
75.27
40%
-63
- C2 -
3U0F
6
?
A:
[6-410]
---
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
I
S
R
A
E
E
--------------
Y
A
E
L
G
F
R
C
Q
V
H
-------
G
A
-
P
-------
D
I
D
I
E
S
L
V
D
R
R
A
---
M
R
F
H
G
R
G
T
A
W
N
H
I
A
M
D
Q
A
I
A
D
A
-
G
L
T
-
E
E
-
E
V
-
S
N
-
E
R
T
--
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
T
L
S
V
L
-
F
D
A
M
G
A
M
S
SK
Y
--
N
--
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
M
V
--
A
P
S
G
E
G
A
I
R
C
M
K
M
A
L
S
---
T
V
T
S
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
A
G
D
-
V
C
--
P
P
I
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
--
P
A
F
A
D
M
P
I
V
R
-
K
R
I
D
N
-
V
-
Q
L
N
---
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y
Q
-
64
PsiBlast_CBE
75.03
40%
-65
- C2 -
3MQD
4
?
A:
[23-427]
---
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
I
S
R
A
E
E
--------------
Y
A
E
L
G
F
R
C
Q
V
H
-------
G
A
-
P
-------
D
I
D
I
E
S
L
V
D
R
R
A
---
M
R
F
H
G
R
G
T
A
W
N
H
I
A
M
D
Q
A
I
A
D
A
-
G
L
T
-
E
E
-
E
V
-
S
N
-
E
R
T
--
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
T
L
S
V
L
-
F
D
A
M
G
A
M
S
SK
Y
--
N
--
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
M
V
--
A
P
S
G
E
G
A
I
R
C
M
K
M
A
L
S
---
T
V
T
S
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
A
G
D
-
V
C
--
P
P
I
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
--
P
A
F
A
D
M
P
I
V
R
-
K
R
I
D
N
-
V
-
Q
L
N
---
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y
Q
-
70
PsiBlast_CBE
71.08
37%
-57
- C2 -
2WGD
5
FAB1_MYCTU
A:
[25-415]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
E
F
------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
69
PsiBlast_CBE
70.20
37%
-58
- C2 -
2WGE
10
FAB1_MYCTU
A:
[25-415]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
E
F
------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
73
PsiBlast_CBE
69.16
37%
-56
- C2 -
4C72
14
?
B:
[48-438]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
EF------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
74
PsiBlast_CBE
69.09
37%
-56
- C2 -
4C72
17
?
A:
[48-438]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
E
F
------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
75
PsiBlast_CBE
68.79
37%
-56
- C2 -
4C71
9
?
B:
[48-438]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
EF------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
71
PsiBlast_CBE
68.78
37%
-56
- C2 -
4C73
13
?
B:
[48-438]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
EF------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
67
PsiBlast_CBE
68.63
37%
-60
- C2 -
4C6V
3
?
A:
[48-438]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
E
F
------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
68
PsiBlast_CBE
68.57
37%
-56
- C2 -
4C6U
6
?
A:
[48-438]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
E
F
------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---
72
PsiBlast_CBE
68.54
37%
-56
- C2 -
4C73
19
?
A:
[48-438]
----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
A
L
E
D
E
F
------------
V
T
K
W
D
L
A
V
K
I
G
-------
G
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
---
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
---
S
P
-
E
V
-
D
P
-
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
--
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
--
P
E
-
I
D
L
D
V
V
A
-
G
E
P
R
Y
-
G
-
D
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
---