@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2202: (2016-04-01 )
MNAGILGVGKYVPEKIVTNFDLEKIMDTSDEWIRTRTGIEERRIARDDEYTHDLAYEAAKVAIKNAGLTPDDIDLFIVATVTQEATFPSVANIIQDRLGAKNAAGMDVEAACAGFTFGVVTAAQFIKTGAYKNIVVVGADKLSKITNWDDRTTAVLFGDGAGAVVMGPVSDDHGLLSFDLGSDGSGGKYLNLDENKKIYMNGREVFRFAVRQMGEASLRVLERAGLEKEDLDLLIPHQANIRIMEASRERLNLPEEKLMKTVHKYGNTSSSSIALALVDAVEEGRIKDNDNVLLVGFGGGLTWGALIIRWGK
Atome Classification :
(37 SA)
.........10........20.-----...-....30........40........50.-----.......60........70........80........90........100-.......110.......120.......130.......140......-.150.......160.......170.......180..------.....190---------.--------.-------.-------.----------.------------.--------.-----------..200-........210.......220.....-..230.......240.......250.-.....--.-260........270.......280...--....----290.......300.......310-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNAGILGVGKYV
P
E
K
I
V
TNF
D
L
-----
E
K
I
-MDT
S
D
E
W
I
R
T
RTG
I
E
E
RRIARDDE
Y
T
H
-----
D
L
A
Y
E
A
A
K
V
A
I
KNAGLTPDD
I
D
L
F
I
V
A
T
VTQEAT
F
P
S
V
A
N
I
I
Q
D
R
LGAKN-AAGM
D
V
E
A
A
CAG
F
T
F
G
V
V
T
A
A
Q
F
I
K
TGAY
K
N
I
V
V
VG
A
D
K
L
S
K
ITNW-DD
R
T
T
A
V
L
F
GDGA
G
A
V
V
MGPVSDDH
G
L
L
S
F
DLGSDG------SGG
K
Y
L
-----------N--------L-------D-------E----------N------------
K
--------
K
-----------
I
Y
M
N
--
G
R
E
V
F
R
F
A
V
R
QM
G
E
A
S
L
R
V
L
E
R
AGLE-KEDL
D
L
LIPHQA
N
I
R
I
M
EA
S
R
E
RLNL-
P
E
E
K
L
--
M
-
K
-
T
V
H
KYGNTSSS
S
I
A
L
A
L
V
D
A
V
E
EGR--IKDN----D
N
V
L
L
V
GFGGG
L
T
W
G
A
L
I
I
RWGK-
73
HHSearch
95.39
58%
-97
- C2 -
1ZOW
-
FABH_STAAW
A:
[1-312]
M
N
V
G
I
K
G
F
G
A
Y
A
P
E
K
I
I
D
N
A
Y
F
-----
E
Q
F
-
L
D
T
S
D
E
W
I
S
K
M
T
G
I
K
E
R
H
W
A
D
D
D
Q
D
T
S
-----
D
L
A
Y
E
A
S
V
K
A
I
A
D
A
G
I
Q
P
E
D
I
D
M
I
I
V
A
T
A
T
G
D
M
P
F
P
T
V
A
N
M
L
Q
E
R
L
G
T
G
K
-
V
A
S
M
D
Q
L
A
A
C
S
G
F
M
Y
S
M
I
T
A
K
Q
Y
V
Q
S
G
D
Y
H
N
I
L
V
V
G
A
D
K
L
S
K
I
T
D
L
-
T
D
R
S
T
A
V
L
F
G
D
G
A
G
A
V
I
I
G
E
V
S
E
G
R
G
I
I
S
Y
E
M
G
S
D
G
------
T
G
G
K
H
L
-----------
Y
--------
L
-------
D
-------
K
----------
D
T-----------
G
--------
K
-----------
L
K
M
N
--
G
R
E
V
F
K
F
A
V
R
I
M
G
D
A
S
T
R
V
V
E
K
A
N
L
T
-
S
D
D
I
D
L
F
I
P
H
Q
A
N
I
R
I
M
E
S
A
R
E
R
L
G
I
-
S
K
D
K
M
--
S
-
V
-
S
V
N
K
Y
G
N
T
S
A
A
S
I
P
L
S
I
D
Q
E
L
K
N
G
K
--
L
K
D
D
----
D
T
I
V
L
V
G
F
G
G
G
L
T
W
G
A
M
T
I
K
W
G
--
1
PsiBlast_PDB
95.22
58%
-96
- C2 -
1ZOW
-
FABH_STAAW
A:
[1-312]
M
N
V
G
I
K
G
F
G
A
Y
A
P
E
K
I
I
D
N
A
Y
F
-----
E
Q
F
-
L
D
T
S
D
E
W
I
S
K
M
T
G
I
K
E
R
H
W
A
D
D
D
Q
D
T
S
-----
D
L
A
Y
E
A
S
V
K
A
I
A
D
A
G
I
Q
P
E
D
I
D
M
I
I
V
A
T
A
T
G
D
M
P
F
P
T
V
A
N
M
L
Q
E
R
L
G
T
G
K
-
V
A
S
M
D
Q
L
A
A
C
S
G
F
M
Y
S
M
I
T
A
K
Q
Y
V
Q
S
G
D
Y
H
N
I
L
V
V
G
A
D
K
L
S
K
I
T
D
L
-
T
D
R
S
T
A
V
L
F
G
D
G
A
G
A
V
I
I
G
E
V
S
E
G
R
G
I
I
S
Y
E
M
G
S
D
G
------
T
G
G
K
H
L
-----------
Y
--------
L
-------
D
-------
K
----------
D
------------
T
G-------
K
-----------
L
K
M
N
--
G
R
E
V
F
K
F
A
V
R
I
M
G
D
A
S
T
R
V
V
E
K
A
N
L
T
-
S
D
D
I
D
L
F
I
P
H
Q
A
N
I
R
I
M
E
S
A
R
E
R
L
G
I
-
S
K
D
K
M
--
S
-
V
-
S
V
N
K
Y
G
N
T
S
A
A
S
I
P
L
S
I
D
Q
E
L
K
N
G
K
--
L
K
D
D
----
D
T
I
V
L
V
G
F
G
G
G
L
T
W
G
A
M
T
I
K
W
G
--
2
PsiBlast_PDB
94.53
58%
-92
- C2 -
3IL7
-
FABH_STAAR
A:
[1-313]
M
N
V
G
I
K
G
F
G
A
Y
A
P
E
K
I
I
D
N
A
Y
F
-----
E
Q
F
-
L
D
T
S
D
E
W
I
S
K
M
T
G
I
K
E
R
H
W
A
D
D
D
Q
D
T
S
-----
D
L
A
Y
E
A
S
V
K
A
I
A
D
A
G
I
Q
P
E
D
I
D
M
I
I
V
A
T
A
T
G
D
M
P
F
P
T
V
A
N
M
L
Q
E
R
L
G
T
G
K
-
V
A
S
M
D
Q
L
A
A
C
S
G
F
M
Y
S
M
I
T
A
K
Q
Y
V
Q
S
G
D
Y
H
N
I
L
V
V
G
A
D
K
L
S
K
I
T
D
L
-
T
D
R
S
T
A
V
L
F
G
D
G
A
G
A
V
I
I
G
E
V
S
E
G
R
G
I
I
S
Y
E
M
G
S
D
G
------
T
G
G
K
H
L
-----------
Y
--------
L
-------
D
-------
K
----------
D
------------
T
G-------
K
-----------
L
K
M
N
--
G
R
E
V
F
K
F
A
V
R
I
M
G
D
A
S
T
R
V
V
E
K
A
N
L
T
-
S
D
D
I
D
L
F
I
P
H
Q
A
N
I
R
I
M
E
S
A
R
E
R
L
G
I
-
S
K
D
K
M
--
S
-
V
-
S
V
N
K
Y
G
N
T
S
A
A
S
I
P
L
S
I
D
Q
E
L
K
N
G
K
--
L
K
D
D
----
D
T
I
V
L
V
G
F
G
G
G
L
T
W
G
A
M
T
I
K
W
G
K
-
10
PsiBlast_PDB
90.72
44%
-100
- C2 -
1HND
1
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
P
N
ADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
21
PsiBlast_CBE
90.46
48%
-98
- C2 -
1UB7
6
?
D:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
-----
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
D
E
Y
T
S
-----
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
--
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
K
E
L
YHACVAPRLPD
G
--------
T
-------
S
-------
M
----------
K
------------
N
--------
R
-----------
L
Y
M
N
--
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
R
V
--
A
-
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
G
R
--
I
R
E
G
----
D
H
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
5
PsiBlast_PDB
90.36
45%
-99
- C2 -
4DFE
-
?
A:
[14-333]
----
V
L
G
T
G
S
Y
L
P
P
N
R
V
T
N
Q
D
L
A
K
R
L
A----
I
E
T
S
D
E
W
I
V
A
R
T
G
I
H
A
R
Y
F
A
E
P
D
V
T
T
S
-----
D
L
A
F
I
A
S
Q
R
A
I
E
A
A
D
I
D
P
Q
S
I
D
L
I
I
V
A
T
S
T
P
D
F
V
F
P
S
T
A
C
L
L
Q
N
K
L
G
I
R
N
H
G
A
A
F
D
V
Q
A
V
C
S
G
F
A
Y
A
V
A
T
A
D
S
F
I
R
S
G
Q
H
R
T
A
L
V
I
G
A
E
T
F
S
R
I
L
D
F
-
K
D
R
T
T
C
V
L
F
G
D
G
A
G
A
V
I
L
-
Q
A
S
D
E
P
G
V
L
A
S
A
L
H
A
D
G
------
S
H
S
N
I
L
-----------
C
--------
T
-------
P
-------
G
----------
N
------------
V
--------
N
GGVVSGS
A
F
--
L
H
M
D
--
G
Q
A
V
F
K
L
A
V
N
V
L
E
K
V
A
V
E
A
L
E
K
A
N
L
S
-
A
E
Q
I
D
W
L
I
P
H
Q
A
N
I
R
I
M
Q
S
T
C
R
K
L
G
L
-
P
Q
E
R
M
--
I
-
V
-
T
V
G
E
H
G
N
T
S
A
A
S
I
P
L
A
L
D
V
A
V
R
D
G
R
--
I
K
R
G
----
Q
N
V
L
I
E
G
V
G
G
G
F
T
W
G
A
S
V
I
R
Y
---
22
PsiBlast_CBE
89.87
48%
-95
- C2 -
1UB7
4
?
C:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
-----
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
D
E
Y
T
S
-----
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
--
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
K
E
L
YHACVAPRLPD
G
--------
T
-------
S
-------
M
----------
K
------------
N
--------
R
-----------
L
Y
M
N
--
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
R
V
--
A
-
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
G
R
--
I
R
E
G
----
D
H
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
9
PsiBlast_PDB
89.81
44%
-99
- C2 -
1HN9
1
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
P
N
ADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
3
PsiBlast_PDB
89.76
49%
-101
- C2 -
2EBD
-
FABH_AQUAE
A:
[1-309]
M
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
-----
E
K
I
-
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
K
E
E
T
I
T
Y
------
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
-
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
-
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
K
S
D
I
L
A
T
R
M
Y
A
E
G
------
S
L
E
E
L
L
-----------
H
--------
A
-------
D
-------
N
----------
C
------------
G
--------
Y
-----------
I
R
M
K
--
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
-
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
-
P
K
E
K
V
--
F
-
V
-
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
K
E
G
K
--
V
K
R
G
----
D
L
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
Y
---
24
PsiBlast_CBE
89.70
44%
-100
- C2 -
2GYO
3
FABH_ECOLI
B:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
PNADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
25
PsiBlast_CBE
89.63
44%
-100
- C2 -
2EFT
4
FABH_ECOLI
B:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
PNADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
70
HHSearch
89.61
45%
-98
* C2 *
1HNJ
2
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
-------
P
-------
N
----------
A
------------
D
RVNPENSI
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
11
PsiBlast_PDB
89.46
44%
-99
- C2 -
1HNJ
2
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
P
N
ADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
26
PsiBlast_CBE
89.25
44%
-98
- C2 -
1HN9
1
FABH_ECOLI
B:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
PNADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
14
PsiBlast_PDB
89.11
44%
-100
- C2 -
2GYO
3
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
P
N
ADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
61
Fugue
88.99
50%
-95
- C2 -
1UB7
4
?
A:
[2-322]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
-----
E
A
Y
L-
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
-----DEY
T
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
--
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
N-
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
K
E
L
-----------
Y
--------
H
-------
A
-------
C
----------
V
------------
A
--------
P
RLPDGTSMK
N
R
L
Y
M
N
--
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
-T
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
R
-VA--
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
------
G
R
IRE
G
D
H
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
G
A
13
PsiBlast_PDB
88.95
44%
-102
- C2 -
2EFT
3
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
P
N
ADRVN
P
-------
E
----------
N
------------
S
I-------
H
-----------
L
T
M
A
--
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
4
PsiBlast_PDB
88.79
48%
-96
- C2 -
1UB7
4
?
A:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
-----
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
D
E
Y
T
S
-----
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
--
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
K
E
L
Y
H
A
CVAPRLPD
G
--------
T
-------
S
-------
M
----------
K
------------
N
--------
R
-----------
L
Y
M
N
--
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
R
V
--
A
-
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
G
R
--
I
R
E
G
----
D
H
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
80
HHSearch
88.75
49%
-98
- C2 -
2EBD
-
FABH_AQUAE
A:
[1-309]
M
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
-----
E
K
I
-
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
-
K
E
E
T
I
T
-----
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
-
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
-
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
K
S
D
I
L
A
T
R
M
Y
A
E
G
------
S
L
E
E
L
L
-----------
H
--------
A
-------
D
-------
N
----------
C
------------
G
--------
Y
-----------
I
R
M
K
--
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
-
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
-
P
K
E
K
V
--
F
-
V
-
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
K
E
G
K
--
V
K
R
G
----
D
L
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
Y
---
23
PsiBlast_CBE
88.48
48%
-95
- C2 -
1UB7
3
?
B:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
-----
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
D
E
Y
T
S
-----
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
--
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
K
E
L
YHACVAPRLPD
G
--------
T
-------
S
-------
M
----------
K
------------
N
--------
R
-----------
L
Y
M
N
--
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
R
V
--
A
-
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
G
R
--
I
R
E
G
----
D
H
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
17
PsiBlast_PDB
88.47
43%
-99
- C2 -
1EBL
1
FABH_ECOLI
A:
[5-317]
----
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
-----
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
-----
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
-
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
E
L
L
-----------
T
--------
L
P
N
ADRV-
N
-------
P
----------
E
------------
N
--------
S
-----------
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
N
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
--
V
-
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
--
I
K
P
G
----
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
41
PsiBlast_CBE
85.36
38%
-103
- C2 -
2QX1
3
FABH_MYCTU
A:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
ID
W
I
T
F
A
Q
----------
N
------------
P
--------
S
G
P
R
P
F
------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
46
PsiBlast_CBE
85.20
38%
-100
- C2 -
2QNX
3
FABH_MYCTU
B:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
---
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
ID
W
I
T
F
A
Q
----------
N
------------
P
--------
S
G
P
R
P
F
------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
49
PsiBlast_CBE
84.92
38%
-100
- C2 -
1HZP
7
FABH_MYCTU
A:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
ID
W
I
T
F
A
Q
----------
N
------------
P
--------
S
G
P
R
P
F
------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
43
PsiBlast_CBE
84.73
38%
-101
- C2 -
2QO1
3
FABH_MYCTU
A:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
ID
W
I
T
F
A
Q
----------
N
------------
P
--------
S
G
P
R
P
F
------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
35
PsiBlast_CBE
84.63
38%
-96
- C2 -
3IL5
1
FABH_ENTFA
D:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
-----
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
-----
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
-
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
P
H
-
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
Y
T
I
-----------
N
ESPFYQGH
K
-------
Q
-------
A
----------
S
------------
K
--------
T
-----------
L
Q
M
E
--
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
--
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
LI
L
G
S
Q
----
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----
55
PsiBlast_CBE
84.03
38%
-98
- C2 -
1U6S
2
FABH_MYCTU
A:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
A
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
ID
W
I
T
F
A
Q
----------
N
------------
P
--------
S
G
P
R
P
F
------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
47
PsiBlast_CBE
83.90
38%
-99
- C2 -
2QNX
3
FABH_MYCTU
A:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
ID
W
I
T
F
A
Q
----------
N
------------
P
--------
S
G
P
R
P
F
------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
54
PsiBlast_CBE
83.66
38%
-97
- C2 -
1U6S
2
FABH_MYCTU
B:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
A
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
IDWITFA
Q
----------
N
------------
P
--------
S
GPRPF------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
36
PsiBlast_CBE
83.64
38%
-91
- C2 -
3IL5
1
FABH_ENTFA
C:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
-----
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
-----
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
-
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
P
H
-
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
Y
T
I
-----------
N
ESPFYQGH
K
-------
Q
-------
A
----------
S
------------
K
--------
T
-----------
L
Q
M
E
--
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
--
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
LI
L
G
S
Q
----
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----
42
PsiBlast_CBE
83.47
38%
-97
- C2 -
2QO1
3
FABH_MYCTU
B:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
IDWITFA
Q
----------
N
------------
P
--------
S
GPRPF------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
20
PsiBlast_PDB
83.17
38%
-93
- C2 -
3IL5
1
FABH_ENTFA
A:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
-----
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
-----
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
-
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
P
H
-
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
Y
T
I
-----------
N
ESPFYQ
G
H
K
-------
Q
-------
A
----------
S
------------
K
--------
T
-----------
L
Q
M
E
--
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
--
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
LI
L
G
S
Q
----
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----
48
PsiBlast_CBE
83.08
38%
-101
- C2 -
1HZP
2
FABH_MYCTU
B:
[14-334]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
-----
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
A
A
-----
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
-
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
D
A
I
-----------
R
--------
Q
-------
D
IDWITFA
Q
----------
N
------------
P
--------
S
GPRPF------
V
R
L
E
--
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
--
A
-
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
T
T
G
A
--
A
K
P
G
----
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
-
37
PsiBlast_CBE
82.71
38%
-91
- C2 -
3IL5
1
FABH_ENTFA
B:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
-----
S
E
M
-
M
D
T
-
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
-----
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
-
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
P
H
-
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
Y
T
I
-----------
N
ESPFYQGH
K
-------
Q
-------
A
----------
S
------------
K
--------
T
-----------
L
Q
M
E
--
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
--
L
-
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
LI
L
G
S
Q
----
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----