@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2222: (2016-04-02 )
MKEIKFLHMADLHLDSPFIGLSTLPQPLFSAIQESTFQSLERITTVAIKEAVDFVLIAGDIYDSEDQSVRAQARFAKEMKRLEVANIPVFMIHGNHDFIEKHKEKLALPSNVHVFSEQVEVMLHKTATGVSVNIYGFSYNERHIRSSRIDEYKVQGDADFHIALLHGSEVSSSEEHDVYAPFRVQEISKKGFDYWALGHIHKRQLLAESPSIYYPGNIQGRNRKESGEKGASIINLSEASTTIDFIGTSPIIWEEIIIPLPKNSEINAFYREITNVLESYQGRSHSYFLHIIIQMASSQKINTNDWLQMLQEEVELSNTTFVWVHKLTTEITNRSNLQTWYESHLAGEEIRRSFEQLQDESAFYQSVEALYLESGANRYLDDLSEQERERLLENALMELGMTLAEVEGDEK
Atome Classification :
(20 SA)
.........10........20........30........-40........50........60...-...-..70........80..---------------..---....90.......--.---100.--.---.---.---.--...110--.....--.--.---.120----------....------....------------.130------------..----------------.......-140-----------...-----..-----------...150----------------.--------..----.--....----160.......--.170..-.---....180--.--..--.---.....190.......200....-.-.-----.-210......-..220...--.----------------.-.-----.230.......-240--.-.......250.-....-...260..---------.....270.-......280---------.........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
E
I
K
F
L
H
M
A
D
LHLDSPFI
G
L
STL
P
Q
P
L
F
S
A
I
Q
E
S
T
F
Q
S
-
L
E
R
I
T
T
V
A
I
K
EAV
D
F
V
L
I
A
G
D
IYDS-E
D
Q
-
S
V
R
A
Q
A
R
F
A
K
E
M
K
R
L
E---------------VA---NI
P
V
F
M
I
HGN
H
D
F
--
I
---
E
K
-
H
--
K
---
E
---
K
---L--ALPSN---
V
H
V
F
S
--
E
--
Q
---
V
E
------------
V
M
LH------KTAT------------
G
V
--------------
S
V
----------------
N
I
Y
G
F
SY-N
E
------------
R
H
I
-----
R
S-----------SRI
D
E
-----------------
Y
--------
K
V----Q--GDA
D
----
F
H
-
I
A
L
L
HGS--EVSSSE-E---HDVYA----
P
--
F
R
--
V
---
Q
E
I
S
KKGFD
Y
W
A
L
G
H
I
H
K
R
Q
L
L
-A-E-----S-P
S
-
I
YYPGN-IQGRNRKE--S----------------G-E-----KG
A
S
I
I
N
LSEA-S
T
---
T
-
I
D
FIGTSP-I
I
-
W
E
E
I
-
I
IPLPKNS---------
E
I
N
A
F
Y
R
E
I
-
T
N
V
L
E
S
Y-----------QGRS
H
S
Y
F
L
H
I
I
I
Q
MASSQKI
N
T
N
D
W
L
Q
M
L
Q
E
E
VELSN
T
T
F
V
W
V
H
K
L
T
T
E
ITNR
S
N
L
Q
T
W
Y
E
SHL
A
G
E
E
I
R
R
S
F
E
Q
L
Q
D
E
S
A
F
Y
Q
S
V
E
A
L
Y
L
ESG
A
N
R
Y
L
D
DL
S
E
Q
E
R
E
R
L
L
E
N
A
L
M
E
LG
M
T
L
A
EVEGDEK
21
HHSearch
82.11
24%
-77
* C1 *
1II7
6
MRE11_PYRFU
A:
[1-312]
---
M
K
F
A
H
L
A
D
I
H
L
G
Y
E
Q
F
H
K
--------
P
Q
R
E
E
E
F
A
E
A
-
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
-
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
P
K
---------------
E
H
---
S
I
P
V
F
A
I
E
G
N
H
D
R
--
T
---
Q
R
G
P
S
V
L
---
N
---
L
---
L
--
E
D
F
G
L
---
V
Y
V
I
G
--
M
--
R
K
E
K
V
E
N
EY
L
T
S
E
R
L
GNG
E
Y
L
V
------
K
G
-
V
------------
Y
K
--------------
D
L
----------------
E
I
H
G
M
K
Y
-
M
S
------------
S
A
W
-----
F
E
-----------
A
N
K
E
I
-----------------
L
--------
K
R
L
---
F
--
R
P
T
D
----
N
A
-
I
L
M
L
H
Q
G
--
V
R
E
V
S
E
A
R
---
G
E
D
Y
F
----
E
--
I
G
--
L
---
G
D
L
-
P
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
Y
S
-----
G
-
S
P
-
V
V
Y
P
G
S
-
L
E
R
W
D
F
G
D
--
Y
E
V
R
Y
E
W
DGI
K
F
K
E
R
Y
G
V
-
N
-----
K
G
F
Y
I
V
E
D
F
K
---------
P
R
F
V
E
I
K
V
-
R
P
-
F
I
D
V
-
K
I
K
G
S
-------------
E
E
E
I
R
K
A
I
-
K
R
L
I
P
--------------
L
I
P
K
N
A
Y
V
R
L
N
I
G
W
R
K
P
F
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.03
27%
-92
- C1 -
3DSD
3
MRE11_PYRFU
A:
[1-227]
---
M
K
F
A
H
L
A
D
I
H
L
-----
G
Y
E
Q
F
H
K
P
---
Q
R
E
E
E
F
A
E
A
-
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
-
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
P
K
---------------
E
H
---
S
I
P
V
F
A
I
E
G
N
S
D
R
--
T
---
Q
R
-
G
--
P
---
S
---
V
---
L
--
N
L
L
E
D
F
GL
V
Y
V
I
G
--
M
--
R
---
K
E
------------
K
V
E
N
------
E
Y
L
T
S
E
R
L
GNGEYL
V
K
G
V
Y
K------------
D
L
----------------
E
I
H
G
M
K
Y
M
S
S
------------
A
W
F
-----
E
A
-----------
N
K
E
I
L
-----------------
K
--------
R
L
----
F
--
R
P
T
D
----
N
A
-
I
L
M
L
H
Q
G
V
R
E
V
S
E
A
R
-
G
---
E
D
-
Y
F
----
E
--
I
G
--
L
---
G
D
L
P
-
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
-
Y
-----
S
-
G
S
P
V
V
Y
P
G
S
-
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
78.98
21%
-56
- C1 -
1II7
6
MRE11_PYRFU
A:
[1-333]
---
M
K
F
A
H
L
A
D
I
H
L
G
Y
E
Q
F
H
K
--------
P
Q
R
E
E
E
F
A
E
A
-
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
-
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
P
K
---------------
E
H
---
S
I
P
V
F
A
I
E
G
N
H
D
R
--
T
---
Q
R
-
G
--
P
S
V
L
N
---
L
---
L
--
E
D
F
G
L
---
V
Y
V
I
G
--
M
--
R
---
K
E
------------
K
V
E
N
------
E
Y
L
T
------------
S
E
R
L
GNG
E
Y
L
V
K
G
V
Y
K
D
L
----------------
E
I
H
G
M
K
Y
-
M
S
------------
S
A
W
-----
F
E
-----------
A
N
K
E
I
-----------------
L
--------
K
R
----
L
F
-
R
P
T
D
----
N
A
-
I
L
M
L
H
Q
G
--
V
R
E
V
S
E
-
A
---
R
G
E
D
Y
----
F
--
E
I
--
G
---
L
G
D
L
P
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
-
Y
-----
S
G
S
P
-
V
V
Y
P
G
S
-
L
E
R
W
D
-------------------------------------
F
G
D
Y
-
E
V
---
R
-
Y
E
W
D
G
I
K
------------------------------------------------------------------------------------
F
K
E
R
Y
G
V
N
K
G
F
Y
I
V
E
D
F
K
P
R
F
V
E
I
K
V
R
P
F
I
D
V
K
I
K
G
S
E
E
E
I
R
K
A
I
K
R
L
I
P
L
I
P
-
K
N
A
Y
V
R
L
N
I
G
W
R
K
P
F
D
L
T
E
I
K
E
L
------------
L
N
V
E
Y
L
K
I
D
T
W
R
I
22
HHSearch
78.82
24%
-83
- C1 -
3THO
6
RAD50_THEMA
B:
[1-301]
---
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
S
R
-
P
----
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
R
N
N
P
-
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
M
---------------
R
----
T
A
P
V
V
V
L
P
G
N
Q
D
W
--
K
---
G
L
K
L
--
F
---
G
---
N
---
F
V
T
S
I
S
S
D
---
I
T
F
V
M
--
S
F-
E
---
P
V
------------
D
V
E
A
------
K
-
R
-------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
------------
E
S
--------K
N
E
G
D
F
R
F
F
L
E
S
R
L
N
K
-----------------
L
Y
-------
E
E
A
---
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
-
L
A
-
G
-------
R
----
E
--
I
I
--
I
N--
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
-
L
I
R
I
D
F
G
E
--
E
----------------
A
D
E
-----
K
G
A
V
F
V
E
L
K
R
G
E
P
P
---
R
-
Y
E
R
I
D
A
S
P
-
L
P
-
L
K
T
L
-
Y
Y
K
K
I
D
T
S
---------
A
L
K
----
S
I
-
R
D
S
C
R
----------------
N
F
P
G
Y
V
R
V
V
Y
E
E
D
S
------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.55
23%
-84
- C1 -
3THO
6
RAD50_THEMA
B:
[1-289]
---
M
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
----------------
M
R
---
T
A
P
V
V
V
L
P
G
N
Q
D
W
----------------
K
---
G
---
L
--
K
L
F
G
N
F
--
V
T
S
I
S
--
S
--
D
---
I
T
------------
F
V
M
S
F
E
P
V
D
V
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
ESK
N
E
G
D
F
----
R
F
F
-----
L
E
-----------
S
R
L
N
K
-----------------
L
Y
E
------
E
A
----
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
L
A
G
-----------------
R
E
--
I
IIN
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
--------------
E
P
-
P
R
-
Y
E
R
I
D
A
S
P
L
P
L
K
T
------------
L
Y
Y
K
K
I
D
T
S
A
L
K
S
I
-----------
R
D
S
C
R
N
F
----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.48
27%
-91
- C1 -
3DSC
1
MRE11_PYRFU
A:
[1-227]
---
M
K
F
A
H
L
A
D
I
H
L
-----
G
Y
E
Q
F
H
K
P
---
Q
R
E
E
E
F
A
E
A
-
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
-
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
P
K
---------------
E
H
---
S
I
P
V
F
A
I
E
G
N
H
D
R
--
T
---
Q
R
-
G
--
P
---
S
---
V
---
L
--
N
L
L
E
D
F
GL
V
Y
V
I
G
--
M
--
R
---
K
E
------------
K
V
E
N
------
E
Y
L
T
S
E
R
L
GNG
E
Y
L
V
K
G
V
Y
K------------
D
L
----------------
E
I
H
G
M
K
Y
M
S
S
------------
A
W
F
-----
E
A
-----------
N
K
E
I
L
-----------------
K
--------
R
L
----
F
--
R
P
T
D
----
N
A
-
I
L
M
L
H
Q
G
V
R
E
V
S
E
A
R
-
G
---
E
D
-
Y
F
----
E
--
I
G
--
L
---
G
D
L
P
-
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
-
Y
-----
S
-
G
S
P
V
V
Y
P
G
S
-
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.91
23%
-77
- C1 -
3THN
5
?
A:
[1-291]
---
M
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
----------------
M
R
---
T
A
P
V
V
V
L
P
G
N
Q
D
W
K
G
L
---
K
L
-
F
--
G
---
N
---
F
---
V
--
T
S
I
S
S
---
D
I
T
F
V
--
M
--
S
---
F
E
------------
P
V
D
V
------
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
E
S
E
A
L
R
K
NEGD
F
R
F
F
-----
L
E
-----------
S
R
L
N
K
-----------------
L
Y
E
------
E
A
----
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
L
A
G
-
Y
---
A
--------
G
--
R
E
--
I
IIN
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
--------------
E
P
-
P
R
-
Y
E
R
I
D
A
S
P
L
P
L
K
T
------------
L
Y
Y
K
K
I
D
T
S
A
L
K
S
I
-----------
R
D
S
C
R
N
F
----------------------------------------------------------------------------------------------------------------------------
41
Fugue
75.93
19%
-83
- C1 -
3AV0
4
MRE11_METJA
A:
[18-386]
G
S
H
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
--------
D
D
R
E
K
D
I
Y
D
S
-
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
---------------
E
N
---
N
I
K
V
Y
I
V
A
G
N
H
E
M
--
P
---
R
R
-
L
--
G
---
E
---
E
S
P
L
A
--
L
L
K
D
Y
---
V
K
I
L
D
--
G
--
K
---
D
V
------------
I
N
V
----------
N
------------
G
E
--------------
E
I
----------------
F
I
C
G
T
Y
Y
-
H
K
------------
K
S
K
-----
R
E
-----------
E
M
L
D
K
-----------------
L
--------
K
N
----
F
--
E
S
E
A
KNYK
K
K
-
I
L
M
L
H
Q
G
-------------
I
N
P
Y
I
----
P
LD
Y
E
--
L
---
E
H
F
D
L
P
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
R
F
-
N
-----
D
-
G
I
-
L
A
Y
S
G
S
-
T
E
I
I
Y
R
N
E
--
Y
----------------
E
-
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
-
D
L
---
D
-
I
S
D
I
E
K
I
D
-
I
E
C
R
E
F
V
-
E
V
N
I
K
D
K
K
---------
S
F
N
E
A
V
N
K
I
-
E
R
C
K
N
K
P
------------------
V
V
F
G
K
I
K
R
E
F
K
P
W
F
D
T
L
K
D
K
I
L
I
N
K
A
I
I
V
D
D
E
F
------------
I
D
M
P
D
N
V
D
I
E
S
L
N
I
K
E
L
L
V
D
Y
A
N
R
Q
G
I
D
G
D
L
V
L
S
L
Y
K
A
L
L
N
-------
N
E
N
W
K
E
L
L
D
E
Y
Y
N
T
K
F
R
G
-------------
10
PsiBlast_PDB
75.36
24%
-75
- C1 -
4NZV
2
?
A:
[16-269]
L
K
E
L
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
----------------
M
R
---
T
A
P
V
V
V
L
P
G
N
H
D
W
----------------
K
---
G
---
L
--
K
L
F
G
N
F
--
V
T
S
I
S
--
S
--
D
---
I
T
------------
F
V
M
S
F
E
P
V
D
V
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
ESEALRKN
E
G
D
F
R
F
F
-----
L
E
-----------
S
R
L
N
K
-----------------
L
Y
E
------
E
A
----
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
L
A
G
-
Y
---
A
G
I
E
Q
----
G
--
R
E
--
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.42
24%
-84
- C1 -
4O43
4
?
A:
[16-269]
L
K
E
L
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
----------------
M
R
---
T
A
P
V
V
V
L
P
G
N
H
D
W
----------------
K
---
G
---
L
--
K
L
F
G
N
F
--
V
T
S
I
S
--
S
--
D
---
I
T
------------
F
V
M
S
F
E
P
V
D
V
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
ESEALRKN
E
G
D
F
R
F
F
-----
L
E
-----------
S
R
L
N
K
-----------------
L
Y
E
------
E
A
----
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
L
A
G
-
Y
---
A
G
I
E
Q
----
G
--
R
E
--
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.18
24%
-81
- C1 -
4O4K
3
?
A:
[16-269]
L
K
E
L
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
----------------
M
R
---
T
A
P
V
V
V
L
P
G
N
H
D
W
----------------
K
---
G
---
L
--
K
L
F
G
N
F
--
V
T
S
I
S
--
S
--
D
---
I
T
------------
F
V
M
S
F
E
P
V
D
V
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
ESEALRKN
E
G
D
F
R
F
F
-----
L
E
-----------
S
R
L
N
K
-----------------
L
Y
E
------
E
A
----
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
L
A
G
-
Y
---
A
G
I
E
Q
----
G
--
R
E
--
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.15
28%
-88
- C1 -
1II7
6
MRE11_PYRFU
A:
[1-227]
---
M
K
F
A
H
L
A
D
I
H
L
-----
G
Y
E
Q
F
H
K
P
---
Q
R
E
E
E
F
A
E
A
-
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
-
S
---
P
G
T
L
K
K
A
I
A
L
L
Q
---------------
I
P
K
E
H
S
I
P
V
F
A
I
E
G
N
H
D
R
--
T
---
Q
R
-
G
--
P
---
S
---
V
---
L
--
N
L
L
E
D
F
GL
V
Y
V
I
G
--
M
--
R
---
K
E
------------
K
V
E
N
------
E
Y
L
T
S
E
R
L
GNG
E
Y
L
V
K
G
V
Y
K------------
D
L
----------------
E
I
H
G
M
K
Y
M
S
S
------------
A
W
F
-----
E
A
-----------
N
K
E
I
L
-----------------
K
--------
R
L
----
F
--
R
P
T
D
----
N
A
-
I
L
M
L
H
Q
G
V
R
E
V
S
E
A
R
-
G
---
E
D
-
Y
F
----
E
--
I
G
--
L
---
G
D
L
P
-
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
-
Y
-----
S
-
G
S
P
V
V
Y
P
G
S
-
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
73.33
18%
-84
- C1 -
3T1I
10
MRE11_HUMAN
A:
[31-393]
-
N
T
F
K
I
L
V
A
T
D
I
H
L
G
F
M
E
K
D
A
---------
V
R
G
N
D
T
F
V
T
-
L
D
E
I
L
R
L
A
Q
E
N
E
V
D
F
I
L
L
G
G
D
L
F
H
E
-
N
K
P
-
S
R
K
T
L
H
T
C
L
E
L
L
R
K
Y
C
MGDRPVQFEILSDQL
N
I
---
S
I
P
V
F
S
I
H
G
N
H
D
D
--
P
---
T
G
A
D
A-
L
---
C
A
L
D
I
---
L
--
S
C
A
G
F
---
V
N
H
F
G
--
R
SM
S
---
V
E
K
I
D
I
S
-------
P
V
L
L
------
Q
K
-
G
------------
S
T
--------------
K
I
----------------
A
L
Y
G
L
G
S
-
I
P
------------
D
E
R
L
Y
R
M
F
V
N
-----------
K
K
V
T
M
-----------------
L
--------
R
P
----
K
ED
E
N
S
W
----
F
N
-
L
F
V
I
H
Q
N
--
R
S
K
-
H
G
-----
S
T
N
F
I
----
P
----------
E
Q
F
L
D
D
F
I
D
L
V
I
W
G
H
E
H
E
C
K
I
A
-
P
-
T
K
N
EQQ
L
-
F
Y
-
I
S
Q
P
G
S
-
S
V
V
T
S
L
S
P
GE
A
----------------
V
-
K
-----
K
H
V
G
L
L
R
I
K
G
R
-
K
M
---
N
-
M
H
K
I
P
L
H
T
V
R
Q
-
F
F
M
E
-
D
I
V
L
A
N
H
P
DIFNPDNPK
V
T
Q
A
I
Q
S
F
C
-
L
E
K
I
E
E
M
L
E
N
A
E
R
E
R
LGN
S
H
Q
P
E
K
P
L
V
R
L
R
V
D
Y
S
G
G
F
----------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.90
24%
-80
- C1 -
4O5G
3
?
A:
[16-269]
L
K
E
L
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
----------------
M
R
---
T
A
P
V
V
V
L
P
G
N
H
D
W
----------------
K
---
G
---
L
--
K
L
F
G
N
F
--
V
T
S
I
S
--
S
--
D
---
I
T
------------
F
V
M
S
F
E
P
V
D
V
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
E
S
E
A
L
RKN
E
G
D
F
R
F
F
-----
L
E
-----------
S
R
L
N
K
-----------------
L
Y
E
------
E
A
----
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
L
A
G
-
Y
---
A
G
I
E
Q
----
G
--
R
E
--
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.83
27%
-88
- C1 -
1S8E
2
MRE11_PYRFU
A:
[1-227]
---
M
K
F
A
H
L
A
D
I
H
L
-----
G
Y
E
Q
F
H
K
P
---
Q
R
E
E
E
F
A
E
A
-
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
-
S
---
P
G
T
L
K
K
A
I
A
L
L
Q
---------------
I
P
K
E
H
S
I
P
V
F
A
I
E
G
N
L
V
R
--
T
---
Q
R
-
G
--
P
---
S
---
V
---
L
--
N
L
L
E
D
F
GL
V
Y
V
I
G
--
M
--
R
---
K
E
------------
K
V
E
N
------
E
Y
L
T
S
E
R
L
GNG
E
Y
L
V
K
G
V
Y
K------------
D
L
----------------
E
I
H
G
M
K
Y
M
S
S
------------
A
W
F
-----
E
A
-----------
N
K
E
I
L
-----------------
K
--------
R
L
----
F
--
R
P
T
D
----
N
A
-
I
L
M
L
H
Q
G
V
R
E
V
S
E
A
R
-
G
---
E
D
-
Y
F
----
E
--
I
G
--
L
---
G
D
L
P
-
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
-
Y
-----
S
-
G
S
P
V
V
Y
P
G
S
-
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.34
27%
-83
- C1 -
4HD0
2
MRE11_PYRFU
A:
[7-233]
---
M
K
F
A
H
L
A
D
I
H
L
-----
G
Y
E
Q
F
H
K
P
---
Q
R
E
E
E
F
A
E
A
-
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
-
S
---
P
G
T
L
K
K
A
I
A
L
L
Q
---------------
I
P
K
E
H
S
I
P
V
F
A
I
E
G
N
H
D
R
--
T
---
Q
R
-
G
--
P
---
S
---
V
---
L
--
N
L
L
E
D
F
GL
V
Y
V
I
G
--
M
--
R
---
K
E
------------
K
V
E
N
------
E
Y
L
T
S
E
R
L
GNG
E
Y
L
V
K
G
V
Y
K------------
D
L
----------------
E
I
H
G
M
K
Y
M
S
S
------------
A
W
F
-----
E
A
-----------
N
K
E
I
L
-----------------
K
--------
R
L
----
F
--
R
P
T
D
----
N
A
-
I
L
M
L
H
Q
G
V
R
E
V
S
E
A
R
-
G
---
E
D
-
Y
F
----
E
--
I
G
--
L
---
G
D
L
P
-
E
G
Y
L
Y
Y
A
R
G
H
I
H
K
R
Y
E
T
-
S
-
Y
-----
S
-
G
S
P
V
V
Y
P
G
S
-
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.57
24%
-75
- C1 -
4O24
4
?
A:
[15-268]
L
K
E
L
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
----------------
M
R
---
T
A
P
V
V
V
L
P
G
N
H
D
W
KG
L
---
K
L
-
F
--
G
---
N
---
F
---
V
--
T
S
I
S
S
---
D
I
T
F
V
--
M
--
S
---
F
E
------------
P
V
D
V
------
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
ESEALRKNEG
D
F
R
F
F
-----
L
E
-----------
S
R
L
N
K
-----------------
L
Y
E
------
E
A
----
L
--
K
K
E
D
----
F
A
-
I
F
M
G
H
F
T
--
V
E
G
L
A
G
-
Y
---
A
G
I
E
Q
----
G
--
R
E
--
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
68.97
24%
-84
- C1 -
3AV0
4
MRE11_METJA
A:
[18-277]
G
S
H
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
--------
D
D
R
E
K
D
I
Y
D
S
-
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
---------------
E
N
---
N
I
K
V
Y
I
V
A
G
N
H
E
M
--
P
---
R
R
L
G
E-
E
---
S
---
P
---
L
A
-
L
L
K
D
Y
---
V
K
I
L
D
--
G
------
K
D
------------
V
I
N
V
------
N
---------------
G
E
--------------
E
I
----------------
F
I
C
G
T
Y
Y
-
H
K
------------
K
S
K
-----
R
E
-----------
E
M
L
D
K
-----------------
L
--------
K
N
F
E
S
E
A
--
K
N
Y
K
----
K
K
-
I
L
M
L
H
Q
G
--
I
N
P
-
Y
----------
I
----
P
--
L
D
YE
L
---
E
H
F
D
L
P
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
-
R
F
N
-----
D
-
G
I
-
L
A
Y
S
G
S
-
T
E
I
I
Y
R
N
E
--
Y
E
D
Y
K
K
-----------
E
-
G
-----
K
G
F
Y
L
V
D
F
S
G
N
-
D
L
DIS
D
-
I
E
K
I
D
I
E
C
-
R
E
-
F
V
E
V
---
N
I
K
D
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.11
23%
-66
- C1 -
3QG5
1
?
C:
[2-264]
----
K
I
L
H
T
S
D
W
H
L
-----
G
V
T
S
W
T
S
S
R
P
V
D
R
R
E
E
L
K
K
A
-
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
-
M
---------------
M
R
---
T
A
P
V
V
V
L
P
G
N
H
D
W
KG
L
---
K
L
-
F
--
G
---
N
---
F
---
V
--
T
S
I
S
S
---
D
I
T
F
V
--
M
--
S
---
F
E
------------
P
V
D
V
------
E
A
K
R
------------
G
Q
--------------
K
V
----------------
R
I
L
P
F
P
Y
-
P
D
ENEGDF------
R
F
F
-----
L
E
-----------
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
D
F
A
I
FM
G
H
F
--------
T
V
----
E
-------------------
R
--
E
I
I
I
N
--------------------------
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
-
K
-----
Q
-
P
L
-
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
--
A
----------------
D
-
E
-----
K
G
A
V
F
V
E
L
K
R
G
-
E
P
---
P
R
Y
E
R
I
D
A
S
P
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.87
21%
-69
- C1 -
4LTY
1
?
C:
[15-272]
---
M
R
I
L
H
T
S
D
W
H
L
G
Q
N
F
----------
Y
S
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
-
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
---------------
Q
T
---
G
C
H
L
V
V
L
A
G
N
H
D
S
--
V
A
T
L
N
E
-
S
--
R
---
D
---
I
---
M
--
A
F
L
N
T
---
T
V
V
A
S
AG
H
--
A
---
P
Q
------------
I
L
P
R
------
R
D
G
T
------------
P
G
--------------
A
V
LCPIPFLRPRDIITSQ-----
E
--
K
Q
------------
Q
H
L
-----
L
A
-----------
A
I
T
D
Y
-----------------
Y
Q
Q
H
Y
A
D
A
C
K
L
----
R
--
G
D
Q
P
----
L
P
I
I
A
T
G
H
L
T
--
T
V
G
A
S
K
-
S
DA
V
R
D
I
Y
I
GTLD
A
--
F
P
--
A
---
Q
N
F
P
P
A
--
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
-
G
-
G
-----
M
-
E
H
-
V
R
Y
C
G
S
-
P
I
P
L
S
F
D
E
--
C
----------------
G
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------