@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2225: (2016-04-02 )
MERIERDTLGEISVDATKYWGAQTERSKRNFAIGDNPMPIEIIYAFAQLKKATAKVNAAEGKLAEEKAIAIGQVCDQIIQGELDEHFPLVVWQTGSGTQSNMNVNEVIAHVANLTLGEGQIHPNDDVNMSQSSNDTFPTAMHIAAYGALVTKLLPEITKMEAVLTEKKNKYMHLVKIGRTHLQDATPLTLGQEISGWEACLTNNKNYLETSMKAILPLAIGGTAVGTGLNASRDFGDKVAEELMKQTGYPFTSDSNKYFALTSHSPINFVHGAIRSLASDLMKIANDIRLLASGPRSGIGELEIPANEPGSSIMPGKVNPTQCEAITMVAAQVMGNDVTINVAASQGNFELNVYKPVIIFNFLESIKLLADSMRSFRVHCLEGLTANEKVIETKVNDSLMLVTALNPHIGYEKAAKIAKLAFDENTTLKEAAIKTGFVTEKEFDLWINPLKMTNL
Atome Classification :
(22 SA)
..-.......10........20........30....--..--..40--.........50........60........70........80.........90........100.......110....-----.-----.----.120---.........130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250........260.......270.......280.......290.......300.....-..310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430..-.....440---........450...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME-RIERDTLG
E
I
S
VD
A
T
KYWGAQTERSKRNFAIGD--NP--M
P
I
---
E
I
I
Y
A
F
A
Q
L
K
K
A
TAKVNAAEGKL
A
E
E
K
A
I
A
I
G
Q
V
C
D
Q
I
I
Q
-GELDEHF
P
L
V
V
W
QTGSGTQSNM
N
V
N
E
V
I
A
H
V
A
NLTL-----G-----E----GQ-----IHPNDDVNMSQSSNDTF
P
T
A
M
H
I
A
A
Y
G
A
L
V
T
K
L
L
P
E
I
T
K
M
E
A
V
L
T
EKKN
K
Y
M
H
L
V
KIG
R
T
HLQDATPLTLGQEISG
W
E
A
C
LTNN
K
N
Y
L
E
T
S
M
K
A
I
L
P
LAIGGTAVGTGLNASR
D
F
G
D
K
V
A
E
E
L
M
K
QTGYP-FTSDS
N
K
Y
F
A
LTSHS
P
I
N
F
V
H
G
A
I
R
S
L
A
S
D
L
M
K
I
A
N
D
I
R
LLASGPRSGIG
E
L
EIPAN-EPGSSIMPGKV
N
P
T
Q
C
E
A
I
T
M
V
A
A
Q
VMGN
D
V
T
I
N
V
A
ASQG
N
F
E
L
N
V
YK
P
V
I
I
F
N
F
L
E
S
I
K
L
L
A
D
S
M
R
S
F
R
V
H
C
LEGLTAN
E
K
V
I
E
T
KVND
S
L
M
L
V
T
ALNPHI
G
Y
E
K
A
A
K
I
A
K
LAFDENT
T
L
K
E
A
AIK-TG
F
V
TEK----E
F
D
L
W
IN
P
L
KMTNL
26
PsiBlast_CBE
95.68
56%
-80
- C4 -
1FUR
1
FUMC_ECOLI
B:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
G
V
R
G
M
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
N
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
4
PsiBlast_PDB
95.28
56%
-77
- C4 -
1FUQ
2
FUMC_ECOLI
A:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
22
PsiBlast_CBE
95.26
56%
-80
- C4 -
1FUQ
2
FUMC_ECOLI
B:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
21
PsiBlast_CBE
95.25
56%
-79
- C4 -
1FUO
2
FUMC_ECOLI
B:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
28
PsiBlast_CBE
95.24
54%
-82
- C4 -
3E04
1
FUMH_HUMAN
D:
[31-486]
---
R
I
E
Y
D
T
F
G
E
L
K
V
P
N
D
K
Y
Y
G
A
Q
T
V
R
S
T
M
N
F
K
I
G
G
VT
E
R
--
M
P
T
---
P
V
I
K
A
F
G
I
L
K
R
A
A
A
E
V
N
Q
D
Y
G
-
L
D
P
K
I
A
N
A
I
M
K
A
A
D
E
V
A
E
-
G
K
L
N
D
H
F
P
L
V
V
W
Q
T
G
S
G
T
Q
T
N
M
N
V
N
E
V
I
S
N
R
A
I
E
M
L
-----
G
GELGS
K
----
I
P
-----
V
H
P
N
D
H
V
N
K
S
Q
S
S
N
D
T
F
P
T
A
M
H
I
A
A
A
I
E
V
H
E
V
L
L
P
G
L
Q
K
L
H
D
A
L
D
A
K
S
K
E
F
A
Q
I
I
K
I
G
R
T
H
T
Q
D
A
V
P
L
T
L
G
Q
E
F
S
G
Y
V
Q
Q
V
K
Y
A
M
T
R
I
K
A
A
M
P
R
I
Y
E
L
A
A
G
G
T
A
V
G
T
G
L
N
T
R
I
G
F
A
E
K
V
A
A
K
V
A
A
L
T
G
L
P
-
F
V
T
A
P
N
K
F
E
A
L
A
A
H
D
A
L
V
E
L
S
G
A
M
N
T
T
A
C
S
L
M
K
I
A
N
D
I
R
F
L
G
S
G
P
R
S
G
L
G
E
L
I
L
P
E
N
-
E
P
G
---
M
P
G
K
V
N
P
T
Q
C
E
A
M
T
M
V
A
A
Q
V
M
G
N
H
V
A
V
T
V
G
G
S
N
G
H
F
E
L
N
V
F
K
P
M
M
I
K
N
V
L
H
S
A
R
L
L
G
D
A
S
V
S
F
T
E
N
C
V
V
G
I
Q
A
N
T
E
R
I
N
K
L
M
N
E
S
L
M
L
V
T
A
L
N
P
H
I
G
Y
D
K
A
A
K
I
A
K
T
A
H
K
N
G
S
T
L
K
E
T
A
I
E
-
L
G
Y
L
T
A
E
----
Q
F
D
E
W
V
K
P
K
D
M
---
5
PsiBlast_PDB
95.20
56%
-79
- C4 -
1KQ7
2
FUMC_ECOLI
A:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
Q
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
1
PsiBlast_PDB
95.15
56%
-79
- C4 -
1FUO
2
FUMC_ECOLI
A:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
23
PsiBlast_CBE
95.02
56%
-80
- C4 -
1FUP
2
FUMC_ECOLI
B:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
2
PsiBlast_PDB
94.97
56%
-78
- C4 -
1YFE
-
FUMC_ECOLI
A:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
3
PsiBlast_PDB
94.66
56%
-81
- C4 -
1FUP
2
FUMC_ECOLI
A:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
25
PsiBlast_CBE
94.52
56%
-80
- C4 -
2FUS
1
FUMC_ECOLI
B:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
G
V
R
G
M
E
----
R
K
-----
V
N
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
65
Fugue
94.51
56%
-82
- C4 -
1FUR
1
FUMC_ECOLI
A:
[4-459]
--V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
----
T
--
E
K
M
P
T
S
-
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
-
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
-----
G
----
V
R
GMERK
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
N
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
-N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
-
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
24
PsiBlast_CBE
94.44
56%
-78
- C4 -
1KQ7
1
FUMC_ECOLI
B:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
Q
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
6
PsiBlast_PDB
94.21
56%
-78
- C4 -
1FUR
1
FUMC_ECOLI
A:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
N
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
8
PsiBlast_PDB
94.19
55%
-77
- C4 -
3TV2
2
?
A:
[1-455]
---
R
M
E
R
D
T
F
G
E
I
A
V
P
A
A
R
L
W
G
A
Q
T
Q
R
S
L
Q
N
F
K
I
S
T
--
E
K
--
Q
S
P
---
E
L
I
H
A
L
A
L
I
K
R
A
A
A
A
V
N
L
E
L
G
V
L
A
Q
D
K
A
N
A
I
V
A
A
A
D
E
I
I
A
-
G
R
H
A
D
E
F
P
L
A
V
W
Q
T
G
S
G
T
Q
T
N
M
N
L
N
E
V
I
A
N
R
A
S
E
L
L
-----
G
GE---
R
----
G
E
SRA--
V
H
P
N
D
D
V
N
R
G
Q
S
S
N
D
V
F
P
T
A
M
H
I
A
A
A
R
A
I
V
D
H
L
L
P
A
L
R
T
L
R
A
T
L
D
A
K
A
A
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
F
S
G
Y
V
A
Q
L
D
Q
G
I
R
H
V
E
A
A
L
P
H
L
Y
E
L
A
Q
G
G
T
A
V
G
T
G
L
N
A
H
P
K
F
A
A
G
V
A
A
E
I
G
R
L
T
G
L
P
-
F
V
S
A
P
N
K
F
E
V
M
A
A
A
D
A
L
V
F
A
H
G
A
L
K
T
V
A
A
S
L
M
K
I
A
N
D
I
R
W
L
A
S
G
P
R
C
G
L
G
E
L
S
I
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
S
E
A
V
T
M
L
C
C
Q
V
F
G
N
D
V
A
V
N
F
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
I
A
H
N
V
L
Q
S
V
R
L
L
A
D
G
A
Q
G
F
N
D
H
C
A
V
G
I
E
P
N
R
A
R
I
D
A
L
L
N
E
S
L
M
L
V
T
A
L
N
P
H
I
G
Y
D
K
A
A
Q
I
A
K
K
A
H
K
E
G
T
T
L
K
A
A
A
L
A
-
L
G
Y
V
T
D
A
----
Q
F
D
E
W
V
R
P
E
H
M
---
7
PsiBlast_PDB
93.86
56%
-79
- C4 -
2FUS
1
FUMC_ECOLI
A:
[5-459]
---
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
--
E
K
--
M
P
T
---
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
-
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
-----
G
GVRGM
E
----
R
K
-----
V
N
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
-
L
G
Y
L
S
E
A
----
E
F
D
S
W
V
R
P
E
Q
M
---
12
PsiBlast_PDB
93.70
54%
-80
- C4 -
3E04
3
FUMH_HUMAN
A:
[31-486]
---
R
I
E
Y
D
T
F
G
E
L
K
V
P
N
D
K
Y
Y
G
A
Q
T
V
R
S
T
M
N
F
K
I
G
G
VT
E
R
--
M
P
T
---
P
V
I
K
A
F
G
I
L
K
R
A
A
A
E
V
N
Q
D
Y
G
-
L
D
P
K
I
A
N
A
I
M
K
A
A
D
E
V
A
E
-
G
K
L
N
D
H
F
P
L
V
V
W
Q
T
G
S
G
T
Q
T
N
M
N
V
N
E
V
I
S
N
R
A
I
E
M
L
-----
G
GELGS
K
----
I
P
-----
V
H
P
N
D
H
V
N
K
S
Q
S
S
N
D
T
F
P
T
A
M
H
I
A
A
A
I
E
V
H
E
V
L
L
P
G
L
Q
K
L
H
D
A
L
D
A
K
S
K
E
F
A
Q
I
I
K
I
G
R
T
H
T
Q
D
A
V
P
L
T
L
G
Q
E
F
S
G
Y
V
Q
Q
V
K
Y
A
M
T
R
I
K
A
A
M
P
R
I
Y
E
L
A
A
G
G
T
A
V
G
T
G
L
N
T
R
I
G
F
A
E
K
V
A
A
K
V
A
A
L
T
G
L
P
-
F
V
T
A
P
N
K
F
E
A
L
A
A
H
D
A
L
V
E
L
S
G
A
M
N
T
T
A
C
S
L
M
K
I
A
N
D
I
R
F
L
G
S
G
P
R
S
G
L
G
E
L
I
L
P
E
N
-
E
P
G
-----
G
K
V
N
P
T
Q
C
E
A
M
T
M
V
A
A
Q
V
M
G
N
H
V
A
V
T
V
G
G
S
N
G
H
F
E
L
N
V
F
K
P
M
M
I
K
N
V
L
H
S
A
R
L
L
G
D
A
S
V
S
F
T
E
N
C
V
V
G
I
Q
A
N
T
E
R
I
N
K
L
M
N
E
S
L
M
L
V
T
A
L
N
P
H
I
G
Y
D
K
A
A
K
I
A
K
T
A
H
K
N
G
S
T
L
K
E
T
A
I
E
-
L
G
Y
L
T
A
E
----
Q
F
D
E
W
V
K
P
K
D
M
---
10
PsiBlast_PDB
93.46
52%
-80
- C4 -
4HGV
2
FUMC_RHIME
A:
[37-488]
---
R
T
E
T
D
T
F
G
P
I
E
V
A
S
D
R
Y
W
G
A
Q
A
Q
R
S
L
G
N
F
K
I
G
W
--
E
K
--
Q
P
L
---
A
I
V
R
A
L
G
I
V
K
Q
A
A
A
R
A
N
M
A
L
G
R
L
D
P
A
I
G
D
A
I
V
K
A
A
Q
E
V
I
D
-
G
K
L
D
E
H
F
P
L
V
V
W
Q
T
G
S
G
T
Q
S
N
M
N
A
N
E
V
V
S
N
R
A
I
E
L
L
-----
G
GVMGS
K
----
K
P
-----
V
H
P
N
D
H
V
N
M
S
Q
S
S
N
D
T
Y
P
T
A
M
H
I
A
C
A
E
R
V
I
H
D
L
L
P
A
L
K
H
L
H
K
A
L
E
E
K
V
K
A
F
D
H
I
I
K
I
G
R
T
H
T
Q
D
A
T
P
L
T
L
G
Q
E
F
S
G
Y
A
A
Q
V
A
S
S
I
K
R
I
E
M
T
L
P
G
L
C
E
L
A
Q
G
G
T
A
V
G
T
G
L
N
A
P
V
G
F
A
E
K
V
A
E
E
I
A
A
I
T
G
I
G
-
F
T
S
A
P
N
K
F
E
A
L
A
A
H
D
S
M
V
F
S
H
G
A
I
N
A
T
A
A
A
L
F
K
I
A
N
D
I
R
F
L
G
S
G
P
R
S
G
L
G
E
L
S
L
P
E
N
-
E
P
G
S
-----
K
V
N
P
T
Q
C
E
A
L
T
Q
V
C
V
Q
V
F
G
N
H
A
A
L
T
F
A
G
S
Q
G
H
F
E
L
N
V
Y
N
P
L
M
A
Y
N
F
L
Q
S
V
Q
L
L
A
D
A
A
I
S
F
T
D
N
C
V
V
G
I
E
A
R
E
D
N
I
K
A
A
L
D
R
S
L
M
L
V
T
A
L
A
P
K
I
G
Y
D
N
A
A
K
I
A
K
T
A
H
K
N
G
T
T
L
R
E
E
A
V
G
-
G
G
Y
V
T
D
E
----
E
F
D
A
V
V
R
P
------
11
PsiBlast_PDB
92.70
53%
-76
- C4 -
3GTD
3
FUMC_RICPR
A:
[26-478]
---
R
I
E
S
D
S
F
G
E
I
Q
I
E
E
K
F
Y
W
G
A
Q
T
Q
R
S
L
N
N
F
K
I
S
K
--
Q
K
--
M
P
K
---
I
L
I
R
A
L
A
I
L
K
K
C
A
A
Q
V
N
Y
E
F
G
D
L
E
Y
K
I
A
T
S
I
D
K
A
I
D
R
I
L
A
-
G
E
F
E
D
N
F
P
L
V
V
W
Q
T
G
S
G
T
Q
T
N
M
N
M
N
E
V
I
A
S
I
A
N
E
E
L
TGKKG
G
-----
K
----
F
P
-----
V
H
P
N
D
H
V
N
K
G
Q
S
S
N
D
S
F
P
T
A
M
H
I
A
T
V
L
A
T
K
Q
Q
L
I
P
A
L
N
N
L
L
T
Y
L
Q
D
K
S
K
D
W
D
K
I
I
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
K
Q
E
F
S
G
Y
I
T
Q
I
E
Y
A
L
E
R
I
E
D
A
L
K
K
V
Y
L
L
A
Q
G
G
T
A
V
G
T
G
I
N
S
K
I
G
F
D
I
K
F
A
Q
K
V
A
E
F
T
Q
Q
P
-
F
K
T
A
P
N
K
F
E
S
L
A
A
H
D
A
L
V
E
F
S
G
T
L
N
T
I
A
V
S
L
M
K
I
A
N
D
I
R
L
L
G
S
G
P
R
C
G
L
G
E
L
H
L
P
E
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
V
E
A
L
T
M
V
C
T
Q
V
M
G
N
H
V
T
V
T
I
A
G
S
N
G
H
L
E
L
N
V
F
K
P
V
I
I
Y
N
I
L
Q
S
I
E
L
L
S
D
S
V
N
S
F
V
T
H
C
V
K
G
L
E
P
N
I
A
R
I
N
T
L
R
D
K
S
L
M
L
V
T
V
L
N
P
H
I
G
Y
D
N
A
A
K
I
A
K
E
A
H
K
Y
G
I
T
L
K
E
A
A
K
K
-
L
N
F
L
S
E
E
----
E
F
D
K
I
V
V
P
E
-----
9
PsiBlast_PDB
92.48
54%
-78
- C4 -
1VDK
-
?
A:
[4-459]
---
R
I
E
R
D
T
M
G
E
V
R
V
P
A
D
K
Y
W
G
A
Q
T
Q
R
S
L
E
N
F
R
I
G
T
--
D
R
FR
M
P
L
---
E
I
I
R
A
Y
G
M
L
K
K
A
A
A
R
A
N
L
E
L
G
E
L
P
E
E
I
A
K
A
I
I
Q
A
A
E
E
V
V
Q
-
G
K
W
D
D
H
F
P
L
V
V
F
Q
T
G
S
G
T
Q
T
N
M
N
V
N
E
V
I
A
N
R
A
S
E
I
L
-----
G
-----
K
PLGS
K
Y
-----
A
H
P
N
D
H
V
N
R
G
Q
S
S
N
D
T
F
P
T
A
M
Y
V
A
V
A
L
A
L
H
Q
R
L
Y
P
A
V
E
G
L
I
R
T
F
T
A
K
A
Q
A
F
D
Q
I
V
K
V
G
R
T
H
L
M
D
A
V
P
I
T
L
G
Q
E
I
G
S
W
A
A
Q
L
K
T
T
L
A
A
V
K
E
M
E
K
G
L
Y
N
L
A
I
G
G
T
A
V
G
T
G
L
N
A
H
P
R
F
G
E
L
V
A
K
Y
L
A
E
E
T
G
L
P
-
F
R
V
A
E
N
R
F
A
A
L
A
A
H
D
E
L
V
N
V
M
G
A
I
R
T
L
A
G
A
L
M
K
I
G
N
D
V
R
W
L
A
S
G
P
Y
A
G
I
G
E
I
T
I
P
A
N
-
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
V
E
A
L
T
M
V
V
V
R
V
Y
G
N
D
H
T
V
A
F
A
G
S
Q
G
N
F
Q
L
N
V
Y
K
P
V
M
A
Y
S
T
L
E
S
I
N
L
L
A
D
A
V
A
S
F
D
A
H
L
A
Q
G
I
E
P
N
L
E
R
I
E
E
Y
L
Q
K
N
P
M
L
A
T
A
L
N
K
A
I
G
Y
D
K
A
A
E
I
V
K
K
A
L
K
--
K
T
L
K
Q
A
A
L
E
-
L
G
Y
L
T
E
E
----
E
F
D
R
I
V
V
P
M
R
L
---
19
PsiBlast_PDB
90.02
46%
-72
- C4 -
3RRP
3
?
A:
[12-469]
---
R
I
E
H
D
T
M
G
E
V
R
V
P
A
E
A
L
W
R
A
Q
T
Q
R
A
V
E
N
F
P
I
S
G
--
R
G
--
L
E
R
---
T
Q
I
R
A
L
G
L
L
K
G
A
C
A
Q
V
N
K
D
L
G
L
L
A
A
E
K
A
D
A
I
I
A
A
A
Q
E
I
A
D
-
G
K
H
D
D
Q
F
P
I
D
V
F
Q
T
G
S
G
T
S
S
N
M
N
A
N
E
V
I
A
S
I
A
A
Q
A
T
-----
P
-----
P
----
V
V
-----
V
H
P
N
D
D
V
N
M
S
Q
S
S
N
D
T
F
P
T
A
T
H
L
A
A
T
E
A
A
V
R
D
L
I
P
A
L
E
Y
L
Q
Q
A
L
A
T
K
A
K
A
W
K
T
V
V
K
S
G
R
T
H
L
M
D
A
V
P
V
T
L
G
Q
E
F
G
G
Y
A
R
Q
I
E
A
G
I
E
R
V
K
A
T
L
P
R
L
G
E
L
P
I
G
G
T
A
V
G
T
G
L
N
A
P
D
G
F
G
A
K
V
V
E
V
L
K
Q
S
T
G
L
S
E
L
K
T
A
S
D
S
F
E
A
Q
A
A
R
D
G
L
V
E
G
S
G
A
L
K
T
I
A
A
S
L
T
K
I
A
N
D
I
R
W
M
G
S
G
P
L
T
G
L
G
E
I
Q
L
P
D
L
-
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
L
P
E
A
V
T
Q
V
A
A
Q
V
I
G
N
D
A
A
I
T
V
G
G
L
S
G
A
F
E
L
N
V
Y
I
P
V
M
A
R
N
L
L
E
S
F
T
L
L
A
N
V
S
R
L
F
V
D
K
C
V
D
G
L
V
A
N
E
D
H
L
R
T
L
A
E
S
S
P
S
I
V
T
P
L
N
S
A
I
G
Y
E
E
A
A
A
V
A
K
E
A
L
K
E
R
K
T
I
R
Q
T
V
I
D
-
R
G
L
I
G
D
K
LS
I
E
E
L
D
K
R
L
D
V
L
A
M
A
K
V
39
PsiBlast_CBE
88.93
46%
-74
- C4 -
3RRP
4
?
B:
[12-469]
---
R
I
E
H
D
T
M
G
E
V
R
V
P
A
E
A
L
W
R
A
Q
T
Q
R
A
V
E
N
F
P
I
S
G
--
R
G
--
L
E
R
---
T
Q
I
R
A
L
G
L
L
K
G
A
C
A
Q
V
N
K
D
L
G
L
L
A
A
E
K
A
D
A
I
I
A
A
A
Q
E
I
A
D
-
G
K
H
D
D
Q
F
P
I
D
V
F
Q
T
G
S
G
T
S
S
N
M
N
A
N
E
V
I
A
S
I
A
A
Q
A
T
-----
P
-----
P
----
V
V
-----
V
H
P
N
D
D
V
N
M
S
Q
S
S
N
D
T
F
P
T
A
T
H
L
A
A
T
E
A
A
V
R
D
L
I
P
A
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