@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2234: (2016-04-02 )
MTNANGNLKKCPITISSYTLGTEVSFPKRVKVAAENGFDGIGLRAENYVDALAAGLTDEDMLRILDEHNMKVTEVEYITQWGTAEDRTAEQQKKEQTTFHMARLFGVKHINCGLLEKIPEEQIIVALGELCDRAEELIIGLEFMPYSGVADLQAAWRVAEACGRDNAQLICDTWHWARANQTAESIKNVPADRIVSIQLCDVHETPYKELREESLHDRLAPGEGYGDTVGFAKILKEHGVNPRVMGVEVISDSMVATGLEYAALKVYNATKKVLDEAWPEISPR
Atome Classification :
(20 SA)
.........10........20-..---.--------......30........40..----......50--------.----.-.......60........70..-......---80---.-------------.-------..-----.-.--.-..90....-....100.......110-------..--.---.-------------------.---..120.----......130..---..--...140..--..--------.---.-.150.......160.--......170.......180...--.-....190.--.......200.......---210---..--------.......220...-.-...230.......240..-.....250..-.-----------------.-----------------...260-.........270.......280..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNANGN
L
K
K
C
P
I
T
I
S
S
Y
T
L--GT---E--------VSFP
K
R
V
K
V
A
AENGFDGIG
L
----
R
A
E
N
Y
V
D
---------
A
----
L
-
A
AGL
T
D
E
D
M
L
R
I
L
D
EHN
M
K
V
T
-
E
V
E
Y
I
T---Q----W-------------G-------TA-----E-D--
R
-
T
A
E
Q
Q
K
K
E
-
Q
T
T
F
H
M
A
R
L
FGVKHIN
C
-------
G
L
--
L
---
E
-------------------K---I
P
E
E
Q
I
----
I
V
A
L
G
E
L
C
D
R
A
---
E
E
--
L
I
I
G
L
EFM--PY--------S---G-
V
A
D
L
Q
A
A
W
R
V
A
E
A
CG--RDN
A
Q
L
I
C
DTWHWARAN-
Q
T
A
E
--
S
-
I
KNVP-AD--
R
I
V
S
I
Q
L
CDVHET
P
Y
K
E
---
L
-----
R
E
--------
E
S
L
H
DRLAPGEGY-G-D
T
V
G
F
A
K
I
L
K
EHGVNP
R
V
-
M
G
V
E
VIS
D
S
M
-
V
-----------------
A
-----------------
T
G
L
E
---
Y
A
A
L
K
V
Y
N
A
T
K
K
V
L
D
E
AWPEISPR
1
PsiBlast_PDB
99.80
97%
-105
- C3 -
2G0W
2
?
A:
[22-296]
---------
K
C
P
I
T
I
S
S
Y
T
L
--
G
T
---
E
--------
V
S
F
P
K
R
V
K
V
A
A
E
N
G
F
D
G
I
G
L
----
R
A
E
N
Y
V
D
---------
A
----
L
-
A
A
G
L
T
D
E
D
M
L
R
I
L
D
E
H
N
M
K
V
T
-
E
V
E
Y
I
T
---
Q
----
W
-------------
G
-------
T
A
-----
E
-
D
--
R
-
T
A
E
Q
Q
K
K
E
-
Q
T
T
F
H
M
A
R
L
F
G
V
K
H
I
N
C
-------
G
L
--
L
---
E
-------------------
K
---
I
P
E
E
Q
I
----
I
V
A
L
G
E
L
C
D
R
A
---
E
E
--
L
I
I
G
L
E
F
M
--
P
Y
--------
S
---
G
-
V
A
D
L
Q
A
A
W
R
V
A
E
A
C
G
--
R
D
N
A
Q
L
I
C
D
T
W
H
W
A
R
A
N
-
Q
T
A
E
--
S
-
I
K
N
V
P
-
A
D
--
R
I
V
S
I
Q
L
C
D
V
H
E
T
P
Y
K
E
---
L
-----
R
E
--------
E
S
L
H
D
R
L
A
P
G
E
G
Y
-
G
-
D
T
V
G
F
A
K
I
L
K
E
H
G
V
N
P
R
V
-
M
G
V
E
V
I
S
D
S
M
-
V
-----------------
A
-----------------
T
G
L
E
---
Y
A
A
L
K
V
Y
N
A
T
K
K
V
L
D
E
A
W
P
E
I
S
P
R
8
HHSearch
97.86
96%
-107
- C3 -
2G0W
2
?
A:
[22-296]
---------
K
C
P
I
T
I
S
S
Y
T
L
--
G
T
---
E
--------
V
S
F
P
K
R
V
K
V
A
A
E
N
G
F
D
G
I
G
L
----
R
A
E
N
Y
V
D
---------
A
----
L
-
A
A
G
L
T
D
E
D
M
L
R
I
L
D
E
H
N
M
K
V
T
-
E
V
E
Y
I
T
---
Q
----
W
-------------
G
-------
T
A
-----
E
D
R
--
T
A
E
Q
Q
K
K
--
E
-
Q
T
T
F
H
M
A
R
L
F
G
V
K
H
I
N
C
-------
G
L
--
L
---
E
-------------------
K
---
I
P
E
E
Q
I
----
I
V
A
L
G
E
L
C
D
R
A
E--
E
---
L
I
I
G
L
E
F
M
--
P
Y
--------
S
---
G
-
V
A
D
L
Q
A
A
W
R
V
A
E
A
C
G
--
R
D
N
A
Q
L
I
C
D
T
W
H
W
A
R
A
N
-
Q
T
A
E
--
S
-
I
K
N
V
P
-
A
D
--
R
I
V
S
I
Q
L
C
D
V
H
E
T
P
Y
K
E
---
L
-----
R
E
--------
E
S
L
H
D
R
L
A
P
G
E
G
Y
-
G
-
D
T
V
G
F
A
K
I
L
K
E
H
-
G
V
N
P
R
V
M
G
V
E
V
I
S
D
S
M
-
V
-----------------
A
-----------------
T
G
L
E
---
Y
A
A
L
K
V
Y
N
A
T
K
K
V
L
D
E
A
W
P
E
I
S
P
R
3
PsiBlast_PDB
66.00
24%
-104
- C3 -
1I6N
1
IOLI_BACSU
A:
[20-248]
------------------------------------------
L
E
L
C
E
K
H
G
Y
D
Y
I
E
I
----
R
T
M
D
K
L
P
---------
E
----
Y
-
L
K
D
H
S
L
D
D
L
A
E
Y
F
Q
T
H
H
I
K
P
L
-
A
L
N
A
L
V
---
F
----
F
-------------
N
-------
N
R
-----
D
-
E
--
K
-
G
H
N
E
I
I
T
E
F
K
G
M
M
E
T
C
K
T
L
G
V
K
Y
V
V
A
-------
V
P
--
L
VTE
Q
-------------------
K
---
I
V
K
E
E
I
K
K
S
S
V
D
V
L
T
E
L
S
D
I
A
---
E
P
YG
V
K
I
A
L
E
F
V
GH
P
Q
--------
C
---
T
-
V
N
T
F
E
Q
A
Y
E
I
V
N
T
V
N
--
R
D
N
V
G
L
V
L
D
S
F
H
F
H
A
M
G
-
S
N
I
E
--
S
-
L
K
Q
A
D
-
G
K
--
K
I
F
I
Y
H
I
D
D
T
E
D
F
P
I
G
F
---
L
-----
T
D
--------
E
---
D
R
V
W
P
G
Q
G
A
-
I
-
D
L
D
A
H
L
S
A
L
K
E
I
G
F
S
-
D
V
-
V
S
V
E
L
F
------------------------------------------------------------------------
9
HHSearch
61.69
16%
-85
- C3 -
3U0H
5
?
A:
[3-280]
---------
A
M
E
P
C
L
H
P
T
L
V
---
D
---
E
--------
T
S
L
V
L
Y
L
D
L
A
R
E
T
G
Y
R
Y
V
D
V
----
P
F
H
W
L
E
A
---------
E
----
A
--
E
R
H
G
D
A
A
V
E
A
M
F
Q
R
R
G
L
V
L
A
-
N
L
G
L
P
L
---
N
----
L
-------------
Y
-------
D
S
-----
E
-
P
--
V
-
F
L
R
E
L
S
L
L
-
P
D
R
A
R
L
C
A
R
L
G
A
R
S
V
T
A
-------
F
L
--
W
---
P
SMDEE
P
-------------
V
---
R
Y
I
S
Q
L
----
A
R
R
I
R
Q
V
A
V
E
L
L
PL
G
---
M
R
V
G
L
E
Y
V
--
G
P
HHLRHRRY
P
---
F
-
V
Q
S
L
A
D
L
K
T
F
W
E
A
I
G
--
A
P
N
V
G
A
L
V
D
S
Y
H
W
Y
T
A
G
-
E
H
E
D
--
D
-
L
A
Q
L
P
-
P
E
--
K
V
V
Y
V
H
I
N
D
T
R
D
A
P
E
D
--------------------
A
H
D
G
K
R
L
L
P
G
D
G
R
-
I
-
P
L
V
P
F
L
R
G
L
Y
L
A
-
G
Y
R
G
P
-
V
A
A
E
V
L
H
E
T
P
-
L
-----------------
D
-----------------
G
T
G
E
---
S
R
A
R
L
V
R
E
R
L
E
K
L
I
A
L
A
K
------
12
HHSearch
60.32
16%
-77
- C3 -
3CQJ
2
ULAE_ECO57
A:
[16-291]
---------
Q
I
P
L
G
I
Y
E
K
A
L
--
P
A
---
G
--------
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
----
S
V
D
E
T
D
E
---------
R
L
S
R
L
D
-
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
---
H
R
R
F
P
L
-------------
G
-------
S
E
-----
D
-
D
A
-
V
-
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
-------
A
G
--
Y
---
D
VYY
Q
E
A
N
------------
N
---
E
T
R
R
R
F
----
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
---
V
T
L
A
M
E
I
M
--
D
Y
--------
P
---
L
-
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
--
N
P
W
F
Q
L
Y
P
D
I
G
N
L
S
A
W
D
-
N
D
V
Q
--
M
-
E
L
Q
A
G
-
I
G
--
H
I
V
A
V
H
V
K
D
T
K
P
G
V
-------------------------
F
K
N
V
P
F
G
E
G
V
-
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
-
G
Y
C
G
P
-
Y
L
I
E
M
W
S
E
T
A
-------------------------------------
E
D
P
A
---
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-----
21
HHSearch
59.97
16%
-82
- C3 -
2ZVR
-
Y416_THEMA
A:
[1-266]
----------
M
K
L
S
L
V
I
S
T
S
--
D
F
---
K
--------
G
D
L
R
K
G
M
E
L
A
K
R
V
G
Y
Q
A
V
E
I
----
A
V
R
D
P
S
-------------------
I
V
D
W
N
E
V
K
I
L
S
E
E
L
N
L
P
I
C
-
A
I
G
T
G
Q
---
A
----
Y
-------------
L
A
DGLSLT
H
P
-----
N
-
D
--
E
I
R
K
K
A
I
E
R
V
-
V
K
H
T
E
V
A
G
M
F
G
A
L
V
I
I
G
-------
L
V
--
R
---
G
RREGRS
Y
------------
E
---
E
T
E
E
L
F
----
I
E
S
M
K
R
L
L
E
L
T
E--
H
---
A
K
F
V
I
E
P
L
--
N
R
YET-----
D
---
F
-
I
N
T
I
D
D
A
L
R
I
L
R
K
I
N
--
S
N
R
V
G
I
L
A
D
T
F
H
M
N
I
E
E
-
V
N
I
P
--
E
S
L
K
R
-
A
-
G
E
--
K
L
Y
H
F
H
V
A
D
S
N
------------------------------
R
W
A
P
G
C
G
H
-
F
-
D
F
R
S
V
F
N
T
L
K
E
I
-
G
Y
N
R
Y
-
V
S
V
E
C
L
P
L
P
G
--------------------------------------
G
M
E
---
E
A
A
E
I
A
F
K
T
L
K
E
L
I
----------
33
Fugue
59.06
15%
-80
- C3 -
3CQJ
2
ULAE_ECO57
A:
[16-291]
---------
Q
I
P
L
G
I
Y
E
K
A
L
--
P
A
---
G
--------
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
VDE
T
D
E
R
L
S
R
---------
L
----
D
-
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
---
H
----
R
-------------
R
-------
F
P
LGSED
D
-
A
--
V
-
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
A
GYDVYY
Q
E
--
A
---
N
-------------------
N
---
E
T
R
R
R
F
----
R
D
G
L
K
E
S
V
E
M
A
---
S
R
A
Q
V
T
L
A
M
E
I
M
--
D
Y
--------
P
---
L
-
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
--
N
P
W
F
Q
L
Y
P
D
I
G
N
L
S
A
W
D
-
N
D
V
Q
--
M
-
E
L
Q
A
G
-
I
G
--
H
I
V
A
V
H
V
K
D
T
K
P
G
V
F
K
N
---
V
-----
P
-----------------
F
G
E
G
V
-
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
Y
-
L
-
I
E
M
W
S
E
T
-----------------------------------------
A
---
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
19
HHSearch
57.93
14%
-73
- C3 -
1K77
5
YGBM_ECOLI
A:
[1-259]
---------
M
P
R
F
A
A
N
L
S
M
M
--
F
T
---
E
--------
V
P
F
I
E
R
F
A
A
A
R
K
A
G
F
D
A
V
E
F
----
L
F
P
Y
N
---------------------
Y
S
T
L
Q
I
Q
K
Q
L
E
Q
N
H
L
T
L
A
-
L
F
N
T
A
P
---
G
----
D
-------------
I
NAGEWGL
S
A
-----
L
-
P
--
G
R
E
H
E
A
H
A
D
I
-
D
L
A
L
E
Y
A
L
A
L
N
C
E
Q
V
H
V
-------
M
A
--
G
---
V
V
P
AGED
A
------------
E
---
R
Y
R
A
V
F
----
I
D
N
I
R
Y
A
A
D
R
F
APH
G
---
K
R
I
L
V
E
A
L
--
S
P
GVKPH---
Y
---
L
-
F
S
S
Q
Y
Q
A
L
A
I
V
E
E
V
A
--
R
D
N
V
F
I
Q
L
D
T
F
H
A
Q
K
V
D
-
G
N
L
T
--
H
-
L
I
R
D
Y
-
A
G
--
K
Y
A
H
V
Q
I
A
G
L
P
D
-----------------------------
R
H
E
P
D
D
G
E
-
I
-
N
Y
P
W
L
F
R
L
F
D
E
V
-
G
Y
Q
G
W
-
I
G
C
E
Y
K
P
R
G
L
----------------------------------------------
T
E
E
G
L
G
W
F
D
A
W
R
G
---------
15
HHSearch
57.44
13%
-86
- C3 -
3DX5
5
ASBF_BACAN
A:
[1-274]
----------
M
K
Y
S
L
C
T
I
S
F
--
R
H
---
Q
L
-------
I
S
F
T
D
I
V
Q
F
A
Y
E
N
G
F
E
G
I
E
L
----
W
G
T
H
A
Q
N
---------
L
----
Y
M
Q
E
Y
E
T
T
E
R
E
L
N
C
L
K
D
K
T
L
E
I
T
-
M
I
S
D
Y
L
---
D
----
I
-------------
S
-------
L
S
-----
A
-
D
--
F
-
E
K
-
T
I
E
K
C
-
E
Q
L
A
I
L
A
N
W
F
K
T
N
K
I
R
T
-------
F
A
--
G
---
Q
KGSADFS------------
Q
---
Q
E
R
Q
E
Y
----
V
N
R
I
R
M
I
C
E
L
F
A
Q
H
N
---
M
Y
V
L
L
E
T
H
--
P
N
--------
T
---
L
-
T
D
T
L
P
S
T
L
E
L
L
G
E
V
D
--
H
P
N
L
K
I
N
L
D
F
L
H
I
W
E
S
G
-
A
D
P
V
--
D
-
S
F
Q
Q
L
-
R
P
--
W
I
Q
H
Y
H
F
K
N
I
S
S
A
D
Y
L
H
VFE
P
N
N
V
Y
A
A
A
--------
G
N
R
T
G
M
V
P
L
F
E
G
I
-
V
-
N
Y
D
E
I
I
Q
E
V
R
D
T
---
D
H
F
-
A
S
L
E
W
F
G
H
N
A
----------------------------------------
K
---
D
I
L
K
A
E
M
K
V
L
T
N
R
N
----------
14
HHSearch
56.76
15%
-82
- C3 -
3QC0
12
?
A:
[2-274]
-------
M
Q
V
E
G
L
S
I
N
L
A
T
I
--
R
E
---
Q
--------
C
G
F
A
E
A
V
D
I
C
L
K
H
G
I
T
A
I
A
P
----
W
R
D
Q
V
A
-------------------
A
I
G
L
G
E
A
G
R
I
V
R
A
N
G
L
K
L
T
-
G
L
C
R
G
G
---
F
----
F
-------------
P
-------
A
P
-----
D
-
A
S
G
R
-
E
K
-
A
I
D
D
N
-
R
R
A
V
D
E
A
A
E
L
G
A
D
C
L
V
L
-------
V
A
--
G
---
G
LPGGSKN
I
-----------
D
---
A
A
R
R
M
V
----
V
E
G
I
A
A
V
L
P
H
A
R
A
A
G
---
V
P
L
A
I
E
P
L
--
H
P
MYAADR--
A
---
C
-
V
N
T
L
G
Q
A
L
D
I
C
E
T
L
G
---
P
G
V
G
V
A
I
D
V
Y
H
V
W
W
D
P
-
D
L
A
N
--
Q
-
I
A
R
-
A
-
G
K
M
K
A
I
L
A
H
H
I
C
D
W
L
V
P
T
K
D
---------------------
M
L
T
D
R
G
M
M
G
D
G
V
-
I
-
D
L
K
G
I
R
R
R
I
E
A
A
-
G
F
H
G
A
-
Q
E
V
E
I
F
S
A
D
N
W
W
-----------------
K
-----------------
R
P
A
D
---
E
V
I
A
T
C
V
E
R
Y
R
N
C
-----------
27
HHSearch
56.74
16%
-83
- C3 -
2QUL
1
DT3E_PSECI
A:
[2-289]
----------
N
K
V
G
M
F
Y
T
Y
W
ST
E
W
---
M
--------
V
D
F
P
A
T
A
K
R
I
A
G
L
G
F
D
L
M
E
I
----
S
L
G
E
F
H
N
---------
L
-------
S
D
A
K
K
R
E
L
K
A
V
A
D
D
L
G
L
T
V
M
-
C
C
I
G
L
K
SEY
D
----
F
-------------
A
-------
S
P
-----
D
-
K
S
V
R
-
D
A
G
-
T
E
Y
V
-
K
R
L
L
D
D
C
H
L
L
G
A
P
V
F
A
G
-------
L
T
--
F
CA-
W
PQSPPLDMKDK--------
R
---
P
Y
V
D
R
A
----
I
E
S
V
R
R
V
I
K
V
A
E
D
Y
G
---
I
I
Y
A
L
E
V
V
--
N
R
FEQ-----
W
---
L
-
C
N
D
A
K
E
A
I
A
F
A
D
A
V
D
--
S
P
A
C
K
V
Q
L
D
T
F
H
M
N
I
E
E
-
T
S
F
R
--
D
-
A
I
L
A
C
-
K
G
--
K
M
G
H
F
H
L
G
E
A
------------------------------
N
R
L
P
P
G
E
G
R
-
L
-
P
W
D
E
I
F
G
A
L
K
E
I
-
G
Y
D
G
T
-
I
V
M
E
P
F
M
R
K
G
-
G
S
V
S
R
A
V
GVWRDMSNGAT
D
-----------------
E
E
M
D
---
E
R
A
R
R
S
L
Q
F
V
R
D
K
L
----------
11
HHSearch
56.37
13%
-90
- C3 -
2Q02
5
?
A:
[2-272]
-----
M
N
I
E
K
T
R
F
C
I
N
R
K
I
A
---
P
---
G
--------
L
S
I
E
A
F
F
R
L
V
K
R
L
E
F
N
K
V
E
L
----
R
N
D
M
P
S
G
---------
S
----
V
-
T
D
D
L
N
Y
N
Q
V
R
N
L
A
E
K
Y
G
L
E
I
V
-
T
I
N
A
V
Y
---
P
----
F
-------------
N
-------
Q
L
-----
T
----
E
-
E
V
V
K
--
K
T
-
E
G
L
L
R
D
A
Q
G
V
G
A
R
A
L
V
L
-------
C
P
--
L
---
N
-------------------
D
G
T
I
V
P
P
E
V
T
----
V
E
A
I
K
R
L
S
D
L
F
A
R
Y
D
---
I
Q
G
L
V
E
P
L
--
G
F
--------
R
VS-
S
-
L
R
S
A
V
W
A
Q
Q
L
I
R
E
A
G
--
S
P
-
F
K
V
L
L
D
T
F
H
H
H
L
Y
E
-
E
A
E
K
--
E
-
F
A
S
R
I
D
I
S
--
A
I
G
L
V
H
L
S
G
V
E
D
T
R
P
T
E
---
A
-----
L
----------
A
D
E
Q
R
I
M
L
S
E
K
D
V
M
-
Q
N
Y
Q
Q
V
Q
R
L
E
N
M
-
G
Y
R
G
I
-
Y
A
F
E
P
F
S
S
Q
L
-
A
-----------------
S
-----------------
W
S
E
A
E
I
E
E
Q
I
N
R
S
V
S
L
L
L
Q
------------
22
HHSearch
54.17
14%
-87
- C3 -
3VNI
1
?
A:
[2-290]
----------
M
K
H
G
I
Y
Y
A
Y
W
--
E
Q
---
E
WE------
A
D
Y
K
Y
Y
I
E
K
V
A
K
L
G
F
D
I
L
E
I
----
A
A
S
P
L
P
F
---------
Y
-------
S
D
I
Q
I
N
E
L
K
A
C
A
H
G
N
G
I
T
L
T
-
V
G
H
G
P
S
---
A
EQN-
L
-------------
S
-------
S
P
-----
D
-
P
--
D
I
R
K
N
A
K
A
F
Y
-
T
D
L
L
K
R
L
Y
K
L
D
V
H
L
I
G
G
-------
A
L
--
Y
---
S
YWPIDYTKTID
K
-------
K
---
G
D
W
E
R
S
----
V
E
S
V
R
E
V
A
K
V
A
E
A
C
G
---
V
D
F
C
L
E
V
L
--
N
R
FEN-----
Y
---
L
-
I
N
T
A
Q
E
G
V
D
F
V
K
Q
V
D
--
H
N
N
V
K
V
M
L
D
T
F
H
M
N
I
E
E
-
D
S
I
G
--
G
A
I
R
T
-
A
-
G
S
--
Y
L
G
H
L
H
T
G
E
C
N
------------------------------
R
K
V
P
G
R
G
R
-
I
-
P
W
V
E
I
G
E
A
L
A
D
I
-
G
Y
N
G
S
-
V
V
M
E
P
F
V
R
M
G
-
G
-----------------
T
V
G
S
N
I
KVWRDISNGAD
E
K
M
L
D
---
R
E
A
Q
A
A
L
D
F
S
R
Y
V
L
E
C
--------
17
HHSearch
53.89
13%
-70
- C3 -
3TVA
4
?
A:
[9-288]
--------
P
Y
W
P
I
G
V
F
T
S
V
--------
D
--------
A
G
L
G
V
H
L
E
V
A
Q
D
L
K
V
P
T
V
Q
V
----
H
A
P
H
P
H
T
---------
R
-------
T
R
E
H
A
Q
A
F
R
A
K
C
D
A
A
G
I
Q
V
T
-
V
I
F
G
G
F
---
D
----
G
ESYAD
I
P
T
T
A
R
TV
G
-------
L
V
-----
P
-
L
ET
R
-
A
S
-
R
V
A
E
M
-
K
E
I
S
D
F
A
S
W
V
G
C
P
A
I
G
L
-------
H
I
--
G
---
F
VPESS--------------
S
---
P
D
Y
S
E
L
----
V
R
V
T
Q
D
L
L
T
H
A
A
N
H
G
---
Q
A
V
H
L
E
T
G
--
Q
----------------
E
S
A
D
H
L
L
E
F
I
E
D
V
N
--
R
P
N
L
G
I
N
F
D
P
A
N
M
I
L
Y
G
T
G
N
P
I
--
E
A
L
R
K
-
V
-
A
R
--
Y
V
R
S
I
H
C
K
D
A
L
W
A
P
V
N
E
---------
R
G
--------
K
S
W
G
Q
E
V
A
L
G
T
G
D
-
V
-
G
M
E
A
Y
L
T
T
L
W
E
I
-
G
Y
R
G
P
-
L
T
I
E
R
E
I
P
H
D
-
P
-----------------------------------
V
Q
Q
K
---
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
------
10
HHSearch
52.11
15%
-59
- C3 -
3CNY
2
IOLE_LACPL
A:
[4-300]
----
S
K
A
E
K
D
I
K
W
G
I
A
P
I
G
W
--
R
N
---
D
DIPSIGKD
N
N
L
Q
Q
L
L
S
D
I
V
V
A
G
F
Q
G
T
E
V
----
G
G
F
F
P
----------------------
G
P
E
K
L
N
Y
E
L
K
L
R
N
L
E
I
A
-
G
Q
W
F
S
S
---
Y
----
I
-------------
I
-------
R
D
-----
G
-
I
--
E
-
K
A
S
E
--
A
F
-
E
K
H
C
Q
Y
L
K
A
I
N
A
P
V
A
V
V
-------
S
E
--
Q
---
T
YTIQRSDTANIF
K
D
K
P
Y
F
T
D
---
K
E
W
D
E
V
----
C
K
G
L
N
H
Y
G
E
I
A
A
K
Y
G
---
L
K
V
A
Y
H
H
H
--
M
G
--------
T
---
G
-
I
Q
T
K
E
E
T
D
R
L
M
A
N
T
D
--
P
K
L
V
G
L
L
Y
D
T
G
H
I
A
V
S
D
-
G
D
Y
M
--
A
-
L
L
N
A
H
-
I
D
--
R
V
V
H
V
H
F
K
D
V
R
R
S
K
E
E
E
---
C
-----
R
A
K
GLT
F
Q
G
S
F
L
N
G
M
F
T
V
P
G
D
G
D
-
L
-
D
F
K
P
V
Y
D
K
L
I
A
N
-
N
Y
K
G
W
-
I
V
V
E
A
E
Q
D
P
S
-
K
-----------------------------------
A
N
P
L
---
E
M
A
Q
I
A
H
R
Y
I
K
Q
H
L
I
E
--------
20
HHSearch
51.99
16%
-81
* C3 *
3VYL
2
?
A:
[1-286]
---------
M
A
R
I
G
I
H
S
F
V
W
--
S
A
SSA
Q
--------
S
E
L
E
R
T
L
A
N
T
R
D
A
G
F
D
L
I
E
F
----
S
Y
L
D
P
A
-------------------
D
V
D
I
G
R
L
A
K
R
I
A
D
L
G
L
G
V
A
I
S
I
G
L
P
A
---
D
GD--
I
-------------
S
-------
S
A
-----
D
-
K
--
A
V
A
A
R
G
V
E
I
L
-
N
Q
T
I
A
L
T
R
D
L
G
G
R
K
V
A
G
-------
I
L
SA
G
---
H
GLQVEAPT-----------
R
---
D
Q
W
N
R
S
----
A
A
A
L
A
K
V
A
E
T
A
K
A
A
G
---
V
T
L
N
L
E
I
V
--
N
R
FES-----
N
---
L
-
L
N
T
A
A
Q
G
L
A
F
I
E
D
T
G
--
S
D
N
I
F
L
H
L
D
T
F
H
M
N
I
E
E
-
A
D
V
G
--
L
-
A
I
R
H
A
-
A
G
--
K
I
G
Y
V
H
I
G
E
S
H
R
------------------------------
G
F
L
G
T
G
N
-
I
-
D
F
A
A
I
F
D
A
L
T
A
I
-
G
Y
A
D
D
-
L
S
F
E
S
F
S
S
E
I
-
V
-----------------
D
E
N
L
S
K
K
T
AIWRNLW---
T
D
N
M
---
A
L
A
K
H
A
R
A
F
I
G
L
G
L
E
T
A
R
R
-----
26
HHSearch
51.75
14%
-75
- C3 -
3P6L
4
?
A:
[4-261]
----
K
A
E
K
N
G
W
R
L
G
M
Q
S
Y
S
F
--
H
----
L
--------
F
P
L
T
E
A
L
D
K
T
Q
E
L
G
L
K
Y
I
E
I
----
Y
P
G
H
K
L
G
GKWGDKVFD
F
----
N
-
L
D
A
Q
T
Q
K
E
I
K
E
L
A
A
S
K
G
I
K
I
V
-
G
T
G
V
Y
V
---
A
----
E
------------------------------------
K
S
S
D
--
W
-
E
K
M
F
K
F
A
K
A
M
D
L
E
F
I
T
C
-------
E
P
--
A
---
L
----------------------------------
S
D
W
D
L
V
E
K
L
S
K
Q
Y
N
---
I
K
I
S
V
H
N
H
--
P
Q
--------
P
---
S
D
Y
W
K
P
E
N
L
L
K
A
I
S
G
-
R
--
S
Q
S
L
G
S
C
S
D
V
G
H
W
R
R
E
G
-
L
N
Q
I
--
D
C
L
K
Q
-
L
-
K
G
--
R
I
I
S
L
H
F
K
D
I
A
P
K
K
A
G
E
--------------------
N
E
Q
H
D
V
I
W
G
T
G
I
-
L
-
D
V
K
G
M
L
K
E
L
K
S
Q
-
N
F
K
G
V
-
F
S
I
E
Y
E
Y
N
W
E
--------------------------------------
N
S
V
---
P
D
I
K
E
C
I
Q
Y
F
N
K
T
A
N
E
I
-------
16
HHSearch
51.52
9%
-83
- C3 -
3KWS
4
?
A:
[23-286]
-------
D
L
E
L
K
L
S
F
Q
E
G
I
A
---
P
---
G
--------
E
S
L
N
E
K
L
D
F
M
E
K
L
G
V
V
G
F
E
P
----
G
G
G
G
L
--------------------
A
G
R
V
N
E
I
K
Q
A
L
N
G
R
N
I
K
V
S
-
A
I
C
A
G
F
---
K
GF--
I
-------------
L
-------
S
T
-----
D
-
P
A
I
R
-
K
E
C
-
M
D
T
M
-
K
E
I
I
A
A
A
G
E
L
G
S
T
G
V
I
I
-------
V
P
--
A
---
F
NGQVPALPHT---------
M
---
E
T
R
D
F
L
----
C
E
Q
F
N
E
M
G
T
F
A
A
Q
H
G
---
T
S
V
I
F
E
P
L
--
N
R
--------
K
ECF
Y
-
L
R
Q
V
A
D
A
A
S
L
C
R
D
I
N
--
N
P
G
V
R
C
M
G
D
F
W
H
M
T
W
E
E
-
T
S
D
M
--
G
A
F
I
S
-
G
-
G
E
--
Y
L
Q
H
V
H
V
A
S
R
K
R
R
----------------------------
S
M
P
G
E
D
G
D
-
A
D
N
Y
I
N
G
F
K
G
L
K
M
I
-
G
Y
N
N
Y
-
V
S
F
E
C
G
C
Q
G
D
---------------------------------------
R
N
---
V
V
V
P
A
A
V
K
L
L
R
E
Q
W
E
Q
--------
24
HHSearch
51.32
16%
-72
- C3 -
3WQO
2
Y1311_METJA
A:
[16-264]
---------
D
M
K
F
G
V
S
S
L
V
F
--
L
----
P
--------
E
S
L
T
S
S
M
E
K
I
A
E
H
N
F
D
A
W
E
I
----
V
C
E
G
T
H
Y
---------
L
-------
S
P
K
N
I
K
Y
L
M
E
L
R
D
R
Y
E
V
E
I
V
-
V
H
A
P
F
S
---
D
----
L
-------------
N
PA-----
S
M
-----
N
-
E
--
R
V
R
K
L
T
V
E
C
I
-
R
D
A
I
E
G
A
F
E
L
D
S
E
V
V
V
V
-------
H
P
--
G
---
Y
I
P
ELWSNY
V
----------
S
---
E
I
L
D
N
N
----
F
S
T
L
S
E
I
V
E
I
A
E
D
Y
G
---
I
K
I
G
L
E
N
M
--
P
N
--------
F
RGV
L
-
G
I
T
P
E
S
L
L
E
I
V
K
D
I
D
--
S
K
N
L
G
I
T
F
D
I
G
H
A
N
T
A
G
-
N
P
A
E
F
V
E
K
L
Q
N
-
I
-
G
I
--
G
I
I
H
V
H
A
H
D
N
N
G
Y
D
-------------------------
D
E
H
L
K
I
G
E
G
N
-
I
-
N
F
I
E
V
L
E
K
L
K
E
I
-
G
Y
D
G
V
-
I
S
I
E
N
K
N
I
----------------------------------------------------------------------
25
HHSearch
49.84
13%
-69
- C3 -
1YX1
2
?
A:
[5-254]
---------
L
H
P
V
S
I
S
L
S
S
Y
--
G
A
---
D
L
V
R
S
----
R
G
Q
A
S
F
L
P
L
L
A
M
A
G
A
Q
R
V
E
L
----
R
E
E
L
F
A
G
------------------
P
P
D
T
E
A
L
T
A
A
I
Q
L
Q
G
L
E
C
V
-
F
S
S
P
L
E
---
L
----
W
-------------
R
-------
E
------
D
------
G
Q
L
N
-
P
E
L
-
E
P
T
L
R
R
A
E
A
C
G
A
G
W
L
K
V
-------
S
L
--
G
---
L
-------------------
L
---
P
E
Q
P
D
--------
L
A
A
L
G
R
R
L
A
R
H
G
---
L
Q
L
L
V
E
N
D
--
Q
T
--------
P
---
Q
-
G
G
R
I
E
V
L
E
R
F
F
R
L
A
E
R
Q
Q
L
D
L
A
M
T
F
D
I
G
N
W
R
W
Q
E
-
Q
A
A
D
--
E
A
A
L
R
-
L
-
G
R
--
Y
V
G
Y
V
H
C
K
A
V
I
R
N
R
D
----------------------
G
K
L
V
A
V
P
P
S
A
A
D
-
L
Q
Y
W
Q
R
L
L
Q
H
F
P
E
G
----
V
A
-
R
A
I
E
Y
P
L
Q
G
D
--------------------------------------
D
L
L
---
S
L
S
R
R
H
I
A
A
L
A
R
L
G
Q
---------