@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2236: (2016-04-02 )
MENRISGTTRLLGLIGTPIDHSKSPIMYNYSFQKAGLDYAYLAFDTPIQKVADTIKAIKTFNLRGANVTMPCKSEVLKHMDDLSPAARMIGAVNTIVNEDGKLTGHITDGLGFIANLRDASVDVAGKKMTIIGAGGAATAIQVQCALDGAKEITIFNIKDAFYDKAKQTVASIKQEVPNCIVHIYDLNDTEKLNAEITTSDILVNATLVGMHPNEHETPISDTSVFRKELIVADIIYNPKKTQLLLDAEAAGCKTVGGLGMLLWQGAEAYKLFTGKDMPVSEVKDLYFN
Atome Classification :
(41 SA)
.........10........20........30.......--.40........50........60........70........80........90.......-.--100.......110.......120........130.......140..-.....150.......160.......170...--....180.......190.......200.......210-.......220.......230--.........240.......250..-.....260.......270.......280---........
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENRIS
G
T
T
R
L
L
G
LIGTPIDHSKS
P
I
M
Y
N
Y
SFQKAGL
D
--
Y
A
Y
L
AFD
T
P
I
Q
K
V
A
D
T
I
K
A
I
K
TFNLRGANVTMP
C
K
S
E
V
L
K
H
M
DDL
S
P
A
A
R
M
I
G
A
V
N
T
I
VN-E--DG
K
L
T
G
H
ITD
G
L
G
F
I
A
NLRDA-SVDVAG
K
K
M
T
I
I
GAGG
A
A
T
A
I
Q
V
Q
-
C
ALDGA
K
E
I
T
I
F
NI
K
D
A
F
Y
D
K
A
K
Q
T
V
A
S
I
K
Q
--EVPN
C
I
V
H
I
Y
DLND
T
E
KLN
A
E
I
TTS
D
I
L
V
N
A
T
L
VGMH-PNEHETPI
S
D
T
S
V
F
R
K
E
L
----
I
V
A
D
IIYNPK
K
T
Q
L
L
L
DAEAAGCK-TVG
G
L
G
M
L
L
WQGA
E
A
Y
K
LFTGKDM
P
V
S
----
E
V
K
D
LYFN
25
PsiBlast_CBE
99.50
53%
-110
- C7 -
3TOZ
1
AROE_LISMO
D:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
28
PsiBlast_CBE
99.29
53%
-108
- C7 -
3TNL
2
AROE_LISMO
D:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
26
PsiBlast_CBE
99.29
53%
-110
- C7 -
3TOZ
3
AROE_LISMO
C:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
24
PsiBlast_CBE
99.23
53%
-110
- C7 -
3TOZ
2
AROE_LISMO
E:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
27
PsiBlast_CBE
99.13
53%
-110
- C7 -
3TOZ
4
AROE_LISMO
B:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
1
PsiBlast_PDB
98.79
53%
-108
- C7 -
3TOZ
4
AROE_LISMO
A:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
21
PsiBlast_CBE
98.73
53%
-108
- C7 -
3TOZ
3
AROE_LISMO
H:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
2
PsiBlast_PDB
98.73
53%
-109
- C7 -
3TNL
3
AROE_LISMO
A:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
29
PsiBlast_CBE
98.68
53%
-107
- C7 -
3TNL
3
AROE_LISMO
C:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
22
PsiBlast_CBE
98.62
53%
-108
- C7 -
3TOZ
2
AROE_LISMO
G:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
23
PsiBlast_CBE
98.55
53%
-107
- C7 -
3TOZ
2
AROE_LISMO
F:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
30
PsiBlast_CBE
98.33
53%
-105
- C7 -
3TNL
2
AROE_LISMO
B:
[32-315]
---
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
-
D
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
58
HHSearch
97.91
53%
-105
- C7 -
3TNL
3
AROE_LISMO
A:
[31-315]
--
E
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
--
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
-
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
K
T
V
E
K
I
N
S
--
K
T
D
C
K
A
Q
L
-
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
-
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
----
Y
I
K
E
I
L
F
-
3
PsiBlast_PDB
90.49
41%
-112
- C7 -
1VI2
2
YDIB_ECOLI
A:
[7-285]
------
A
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
--
F
T
Y
M
A
F
E
V
D
N
D
S
F
P
G
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
-
G
F
D
I
K
G
K
T
M
V
L
L
G
A
G
G
A
S
T
A
I
G
A
Q
-
G
A
I
E
G
L
K
E
I
K
L
F
N
R
R
D
E
F
F
D
K
A
L
A
F
A
Q
R
V
N
E
--
N
T
-
D
C
V
V
T
V
T
D
L
A
D
Q
Q
A
F
A
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
-
P
L
E
N
E
S
L
V
N
D
I
S
L
L
H
P
G
L
----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
T
L
W
T
G
K
D
F
P
L
E
----
Y
V
K
Q
V
---
4
PsiBlast_PDB
89.61
41%
-102
- C7 -
1NPD
1
YDIB_ECOLI
A:
[3-283]
----
V
T
A
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
--
F
T
Y
M
A
F
E
V
D
N
D
S
F
P
G
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
-
G
F
D
I
K
G
K
T
M
V
L
L
G
A
G
G
A
S
T
A
I
G
A
Q
-
G
A
I
E
G
L
K
E
I
K
L
F
N
R
R
D
E
F
F
D
K
A
L
A
F
A
Q
R
V
N
E
--
N
T
-
D
C
V
V
T
V
T
D
L
A
D
Q
Q
A
F
A
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
-
P
L
E
N
E
S
L
V
N
D
I
S
L
L
H
P
G
L
----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
T
L
W
T
G
K
D
F
P
L
E
----
Y
V
K
Q
V
---
57
HHSearch
89.35
44%
-103
- C7 -
3T4E
2
YDIB_SALTY
A:
[30-308]
-------
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
--
Y
T
Y
M
A
F
E
V
D
N
T
T
F
A
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
-
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
T
A
I
G
A
Q
-
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
D
F
F
E
K
A
V
A
F
A
K
R
V
N
E
--
N
T
D
C
V
V
T
-
V
T
D
L
A
D
Q
H
A
F
T
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
-
P
L
E
N
E
S
L
I
G
D
V
S
L
L
R
P
E
L
----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
F
P
L
D
----
Y
V
K
Q
V
M
--
31
PsiBlast_CBE
89.16
46%
-100
- C7 -
3T4E
2
YDIB_SALTY
B:
[28-307]
-----
T
A
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
--
Y
T
Y
M
A
F
E
V
D
N
T
T
F
A
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
-
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
T
A
I
G
A
Q
-
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
D
F
F
E
K
A
---
V
A
F
A
K
R
V
N
E
N
T
D
C
V
V
T
V
T
D
L
A
D
Q
H
A
F
T
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
-
P
L
E
N
E
S
L
I
G
D
V
S
L
L
R
P
E
L
----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
F
P
L
D
----
Y
V
K
Q
V
---
5
PsiBlast_PDB
88.76
41%
-107
- C7 -
1O9B
4
YDIB_ECOLI
A:
[7-283]
--------
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
--
F
T
Y
M
A
F
E
V
D
N
D
S
F
P
G
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
-
G
F
D
I
K
G
K
T
M
V
L
L
G
A
G
G
A
S
T
A
I
G
A
Q
-
G
A
I
E
G
L
K
E
I
K
L
F
N
R
R
D
E
F
F
D
K
A
L
A
F
A
Q
R
V
N
E
--
N
T
-
D
C
V
V
T
V
T
D
L
A
D
Q
Q
A
F
A
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
-
P
L
E
N
E
S
L
V
N
D
I
S
L
L
H
P
G
L
----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
T
L
W
T
G
K
D
F
P
L
E
----
Y
V
K
Q
V
---
6
PsiBlast_PDB
88.54
46%
-100
- C7 -
3T4E
2
YDIB_SALTY
A:
[30-307]
-------
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
--
Y
T
Y
M
A
F
E
V
D
N
T
T
F
A
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
-
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
T
A
I
G
A
Q
-
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
D
F
F
E
K
A
---
V
A
F
A
K
R
V
N
E
N
T
D
C
V
V
T
V
T
D
L
A
D
Q
H
A
F
T
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
-
P
L
E
N
E
S
L
I
G
D
V
S
L
L
R
P
E
L
----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
F
P
L
D
----
Y
V
K
Q
V
---
8
PsiBlast_PDB
85.22
34%
-107
- C7 -
2HK7
2
AROE_AQUAE
A:
[2-267]
----
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
--
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
-
L
V
K
E
G
A
K
---
V
F
-----
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
--
K
F
P
L
E
V
V
-----
N
S
P
E
E
V
---
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
-
D
E
D
P
E
--
I
F
N
Y
D
L
I
K
K
D
H
----
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
---
35
PsiBlast_CBE
84.55
34%
-101
- C7 -
2HK9
2
AROE_AQUAE
B:
[8-273]
----
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
--
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
-
L
V
K
E
G
A
K
---
V
F
-----
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
--
K
F
P
L
E
V
V
-----
N
S
P
E
E
V
---
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
-
D
E
D
P
E
--
I
F
N
Y
D
L
I
K
K
D
H
----
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
VAER
S
V
R
D
L
---
10
PsiBlast_PDB
84.29
34%
-102
- C7 -
2HK9
3
AROE_AQUAE
A:
[8-273]
----
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
--
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
-
L
V
K
E
G
A
K
---
V
F
-----
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
--
K
F
P
L
E
V
V
-----
N
S
P
E
E
V
---
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
-
D
E
D
P
E
--
I
F
N
Y
D
L
I
K
K
D
H
----
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
---
34
PsiBlast_CBE
83.71
34%
-99
- C7 -
2HK9
2
AROE_AQUAE
C:
[8-272]
----
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
--
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
-
L
V
K
E
G
A
K
---
V
F
-----
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
--
K
F
P
L
E
V
V
-----
N
S
P
E
E
V
---
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
-
D
E
D
P
E
--
I
F
N
Y
D
L
I
K
K
D
H
----
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
VAER
S
V
R
D
----
33
PsiBlast_CBE
83.38
34%
-94
- C7 -
2HK9
2
AROE_AQUAE
D:
[8-272]
----
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
--
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
-
L
V
K
E
G
A
K
---
V
F
-----
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
--
K
F
P
L
E
V
V
-----
N
S
P
E
E
V
---
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
-
D
E
D
P
E
--
I
F
N
Y
D
L
I
K
K
D
H
----
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
VAER
S
V
R
D
----
72
HHSearch
82.31
34%
-98
- C7 -
2HK9
3
AROE_AQUAE
A:
[7-270]
---
M
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
--
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
-
L
V
K
E
G
A
-
K
V
F
L
W
N
R
T
K
E
---
K
A
I
K
L
A
Q
K
F
P
L
------
E
-----
V
V
N
S
---
P
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
-
D
E
D
P
--
E
I
F
N
Y
D
L
I
K
K
D
H
----
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
----
V
A
E
R
S
V
--
61
HHSearch
81.52
38%
-95
- C7 -
1NVT
2
AROE_METJA
A:
[5-282]
--
S
M
I
N
A
K
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
K
D
K
G
L
N
--
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
-
E
--
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
-
L
A
K
D
N
--
N
I
I
I
A
N
R
T
V
E
---
K
A
E
A
L
A
K
E
I
A
E
--
K
L
N
K
K
F
G
E
E
V
K
F
S
G
---
L
D
V
D
L
D
G
V
D
I
I
I
N
A
T
P
I
G
M
Y
-
P
N
I
D
V
E
P
I
V
K
A
E
K
L
R
E
D
M
----
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
----
V
M
K
N
A
I
I
-
32
PsiBlast_CBE
79.15
39%
-97
- C7 -
1NVT
2
AROE_METJA
B:
[7-269]
----
I
N
A
K
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
K
D
K
G
L
N
--
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
-
E
--
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
-
L
A
K
D
N
--
N
I
I
I
A
N
---
R
T
V
E
K
A
E
A
L
A
K
E
I
A
E
--
K
L
N
K
K
F
G
E
E
V
K
F
S
G
---
L
D
V
D
L
D
G
V
D
I
I
I
N
A
T
P
I
G
M
Y
-
P
N
I
D
V
E
P
I
V
K
A
E
K
L
R
E
D
M
----
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
------------------
69
HHSearch
79.09
34%
-83
- C7 -
2O7S
2
DHQSD_ARATH
A:
[229-512]
---
R
I
G
P
D
T
K
V
Y
G
I
I
G
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
K
S
V
D
F
N
--
G
V
Y
V
H
L
L
V
D
--
N
L
V
S
F
L
Q
A
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
L
R
-
R
KS
D
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
E
D
G
-
L
------
T
V
V
V
I
G
A
G
G
A
G
K
A
L
A
Y
G
-
A
K
E
K
G
A
--
V
V
I
A
N
R
T
Y
E
---
R
A
L
E
L
A
E
A
I
G
G
-------
A
---
L
S
L
T
D
---
L
D
N
Y
-
E
D
G
M
V
L
A
N
T
T
S
M
G
M
Q
-
P
N
V
E
E
T
P
-
I
S
K
D
A
L
K
H
Y
A
----
L
V
F
D
A
V
Y
T
P
R
I
T
R
L
L
R
E
A
E
E
S
G
A
I
-
T
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
P
A
P
K
E
----
L
Y
W
Q
I
M
S
-
7
PsiBlast_PDB
78.52
39%
-100
- C7 -
1NVT
2
AROE_METJA
A:
[7-269]
----
I
N
A
K
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
K
D
K
G
L
N
--
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
-
E
--
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
-
L
A
K
D
N
--
N
I
I
I
A
N
---
R
T
V
E
K
A
E
A
L
A
K
E
I
A
E
--
K
L
N
K
K
F
G
E
E
V
K
F
S
G
---
L
D
V
D
L
D
G
V
D
I
I
I
N
A
T
P
I
G
M
Y
-
P
N
I
D
V
E
P
I
V
K
A
E
K
L
R
E
D
M
----
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
------------------
60
HHSearch
77.55
32%
-95
* C7 *
2D5C
4
AROE_THET8
A:
[1-258]
--------
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
E
S
L
G
L
E
--
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
V
R
-
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
G
-
G
I
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
-
L
R
E
A
G
L
-
E
V
W
V
W
N
R
T
P
Q
---
R
A
L
A
L
A
E
E
F
G
L
------
R
A
---
V
P
L
-------
E
K
A
R
E
A
R
L
L
V
N
A
T
R
V
G
L
E
-
D
P
S
A
--
S
P
L
P
A
E
L
F
P
E
E
G
----
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
----
G
M
E
E
A
A
R
-
37
PsiBlast_CBE
77.14
32%
-79
- C7 -
2GPT
2
DHQSD_ARATH
A:
[228-509]
--
R
R
I
G
P
D
T
K
V
Y
G
I
I
G
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
K
S
V
D
F
N
--
G
V
Y
V
H
L
--
L
V
D
N
L
V
S
F
L
Q
A
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
L
R
-
R
KS
D
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
E
D
G
L-------
T
V
V
V
I
G
A
G
G
A
G
K
A
L
A
Y
G
-
A
K
E
K
G
A
K
V
V
----
I
A
N
R
T
Y
E
R
--
E
L
A
E
A
I
G
----
A
-------
L
S
L
T
D
L
D
N
Y
--
E
--
D
G
M
V
L
A
N
T
T
S
M
G
M
Q
-
P
N
V
E
E
T
P
I
S
K
D
A
L
-
K
H
Y
A
----
L
V
F
D
A
V
Y
T
P
R
I
T
R
L
L
R
E
A
E
E
S
G
A
I
-
T
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
P
A
P
--------
K
E
L
Y
W
Q
20
PsiBlast_PDB
76.44
32%
-80
- C7 -
2O7S
2
DHQSD_ARATH
A:
[228-509]
--
R
R
I
G
P
D
T
K
V
Y
G
I
I
G
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
K
S
V
D
F
N
G
V
Y
V
H
L
L
V
D
N
----
L
V
S
F
L
Q
A
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
L
R
-
R
KS
D
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
E
D
G
L
-------
T
V
V
V
I
G
A
G
G
A
G
K
A
L
A
Y
G
-
A
K
E
K
G
A
-
V
V
----
I
A
N
R
T
Y
E
R
A
L
E
L
A
E
A
I
G
G
---
A
-------
L
S
L
T
D
L
D
N
Y
--
E
--
D
G
M
V
L
A
N
T
T
S
M
G
M
Q
-
P
N
V
E
E
T
P
I
S
K
D
A
L
-
K
H
Y
A
----
L
V
F
D
A
V
Y
T
P
R
I
T
R
L
L
R
E
A
E
E
S
G
A
I
-
T
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
P
A
P
--------
K
E
L
Y
W
Q
67
HHSearch
76.41
30%
-86
- C7 -
1NYT
7
AROE_ECOLI
A:
[1-267]
--------
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
Q
Q
L
N
I
E
--
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
-
L
L
S
L
D
C
-
A
V
T
I
T
N
R
T
V
S
---
R
A
E
E
L
A
K
L
F
A
H
--
T
G
S
I
Q
A
---
L
S
M
D
E
---
L
E
--
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
S
-
G
D
I
P
A
---
I
P
S
S
L
I
H
P
G
I
----
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
----
P
V
I
K
Q
L
Q
-
19
PsiBlast_PDB
75.03
32%
-77
- C7 -
2O7Q
3
DHQSD_ARATH
A:
[228-509]
--
R
R
I
G
P
D
T
K
V
Y
G
I
I
G
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
K
S
V
D
F
N
G
V
Y
V
H
L
L
V
D
N
----
L
V
S
F
L
Q
A
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
L
R
-
R
KS
D
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
E
D
G
L
-------
T
V
V
V
I
G
A
G
G
A
G
K
A
L
A
Y
G
-
A
K
E
K
-
A
K
V
V
----
I
A
N
R
T
Y
E
R
A
L
E
L
A
E
A
I
G
G
--
K
A
-------
L
S
L
T
D
L
D
N
Y
--
E
--
D
G
M
V
L
A
N
T
T
S
M
G
M
Q
-
P
N
V
E
E
T
P
I
S
K
D
A
L
-
K
H
Y
A
----
L
V
F
D
A
V
Y
T
P
R
I
T
R
L
L
R
E
A
E
E
S
G
A
I
-
T
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
P
A
P
--------
K
E
L
Y
W
Q
13
PsiBlast_PDB
71.15
30%
-88
- C7 -
3DOO
1
AROE_STAEQ
A:
[3-260]
-----------
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
Q
S
L
N
L
E
--
N
T
Y
E
A
I
N
V
P
V
N
Q
F
Q
D
I
K
K
I
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
L
V
-
K
--
D
G
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
I
-
Y
E
G
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
E
-
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
T
M
S
R
F
N
N
W
S
L
N
I
N
K
I
--------------
N
L
S
H
A
E
---
S
H
L
D
E
F
D
I
I
I
N
T
T
P
----------------
V
I
S
L
N
R
L
ASH
T
L
V
S
D
I
V
Y
N
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
N
P
-
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
----
A
M
K
N
I
---
17
PsiBlast_PDB
70.93
30%
-91
- C7 -
2EV9
3
AROE_THET8
A:
[6-245]
-------------
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
E
S
L
G
L
E
--
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
V
R
R
-
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
G
-
G
I
P
L
K
G
P
A
L
V
L
G
A
G
--
G
A
G
R
A
V
A
F
-
A
L
R
E
A
G
L
E
V
W
V
W
N
-------
R
T
P
Q
R
A
L
A
L
A
E
--
E
F
G
L
R
A
V
P
L
E
K
A
R
E
----------
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
S
A
S
P
L
P
---
A
E
L
F
P
E
E
G
----
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
------------------
16
PsiBlast_PDB
70.51
30%
-90
- C7 -
2D5C
4
AROE_THET8
A:
[6-245]
-------------
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
E
S
L
G
L
E
--
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
V
R
R
-
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
G
-
G
I
P
L
K
G
P
A
L
V
L
G
A
G
--
G
A
G
R
A
V
A
F
-
A
L
R
E
A
G
L
E
V
W
V
W
N
-------
R
T
P
Q
R
A
L
A
L
A
E
--
E
F
G
L
R
A
V
P
L
E
K
A
R
E
----------
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
S
A
S
P
L
P
---
A
E
L
F
P
E
E
G
----
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
------------------
38
PsiBlast_CBE
69.42
31%
-72
- C7 -
1NYT
5
AROE_ECOLI
D:
[6-254]
-------------
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
Q
Q
L
N
I
E
--
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
A
V
T
I
T
------------
N
R
T
V
-
S
R
A
E
--
E
L
A
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
E
L
E
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
----
S
G
D
I
P
A
I
P
S
S
L
I
H
P
G
I
----
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
------------------
39
PsiBlast_CBE
68.99
31%
-73
- C7 -
1NYT
6
AROE_ECOLI
C:
[6-254]
-------------
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
Q
Q
L
N
I
E
--
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
A
V
T
I
T
------------
N
R
T
V
-
S
R
A
E
--
E
L
A
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
E
L
E
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
----
S
G
D
I
P
A
I
P
S
S
L
I
H
P
G
I
----
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
------------------
40
PsiBlast_CBE
68.43
31%
-69
- C7 -
1NYT
5
AROE_ECOLI
B:
[6-254]
-------------
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
Q
Q
L
N
I
E
--
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
A
V
T
I
T
------------
N
R
T
V
-
S
R
A
E
--
E
L
A
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
E
L
E
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
----
S
G
D
I
P
A
I
P
S
S
L
I
H
P
G
I
----
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
------------------
41
PsiBlast_CBE
68.02
31%
-69
- C7 -
1NYT
7
AROE_ECOLI
A:
[6-254]
-------------
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
Q
Q
L
N
I
E
--
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
A
V
T
I
T
------------
N
R
T
V
-
S
R
A
E
--
E
L
A
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
E
L
E
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
----
S
G
D
I
P
A
I
P
S
S
L
I
H
P
G
I
----
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
------------------