@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2389: (2016-04-03 )
MSKPKIVILGAGYGGLKTLRKLQQRNLEAEIVLVNKNDYHHETTWLHEAAAGTIEPEKLMYPLDKVVNDTKTTFIQDTVVKINKDEKTVTLDANGDISYDYLLIALGSEAETFGISGLKEYAFTITSVESVKKIRAHIEAQFAKWKTDPRDELLTIIVGGAGFTGIEFLGELTNRIPELVKQYDVPREKVRIYCMEAAPKVLPQFDAKLVDYGVGVLEDRGVEFHVGKPVKEATADGVKYAESENEVREIKAATIIWAAGVRGNSVIEASGFEAGRGRVKVNNNLTVPGNEEILIVGDCSLIINPANDRPFPPTAQIAMQQADVAAVNLAKLVKGETDLQDFVYHEKGTVCSLGDNDAIGVVFGKNLKGYPASVMKKVIDDRALLLIGGSGVLASKGKFKFYK
Atome Classification :
(20 SA)
--------.........10........20....--....30........40-.-.-.--.--....50....-.--.-..60........70--..-.-...-..80........90--------------------.-----.--------------------......100.......110-.......--120.......130.......140...----.-----...-150.......160.......170......-.180....--...190.......200.-.-.-....210.......220...----....230.....-----------------------.----.240.----......250.......260......------.-----270.-......280.......290.......300....-..-.-310........320.......330..-------------------...-----------..340..--.....350.......360..-----------.....370.......380.......390.......400.--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MSKP
K
I
V
I
L
GAGY
G
G
L
K
T
L
R
K
L
Q
Q
R--NLE
A
E
I
V
L
V
NKNDYHH-E-
T
-
T
--
W
--
L
H
EAAAGTI
E
-
P
--
E
-
K
L
M
Y
P
L
D
K
VVNDTK--
T
T
-
F
-
I
Q
D
-
T
V
V
K
INKDE
K
T
V
T
L
--------------------D-----A--------------------NGD
I
S
Y
D
Y
L
L
I
A
LGSEA
E
T
-
F
G
I
SG
L
K
--
E
Y
A
F
T
I
T
S
V
E
S
V
K
K
I
R
A
H
I
E
A
Q
F
A
KW----K-----TDP-RD
E
L
L
T
I
I
VGGAG
F
T
G
I
E
F
L
G
E
L
T
N
R
I
P
E
-
L
V
K
Q
YDV
P
--
R
E
K
V
R
I
Y
C
MEA
A
P
K
V
L
P
-
Q
-F-
D
A
K
L
V
D
YGVG
V
L
EDRG
V
E
F
H----VGK
P
V
K
E
ATADG-----------------------V----KYAES----E
N
E
V
R
E
I
K
A
A
T
I
I
W
A
AGVRG
N
S
V
I
E------A-----SGFE-AGR
G
R
V
K
VNN
N
L
TVPGN
E
E
I
L
I
V
GD
C
S
L
I
I
NPA-ND-R-P-FPP
T
A
Q
I
A
M
Q
QA
D
V
A
A
V
N
L
A
K
L
VK-------------------GET-----------
D
L
Q
D
F
V
Y--HEKG
T
V
C
SLGDND
A
I
G
V
V
FG-----------KNLKGY
P
A
S
V
M
K
K
V
IDDR
A
L
L
L
IGGS
G
V
LASKG
K
F
KFYK--
1
PsiBlast_PDB
98.62
54%
-117
- C1 -
4NWZ
1
?
A:
[3-397]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
-
I
-
T
-
T
--
E
--
L
H
Q
P
A
A
G
T
M
H
-
H
--
D
-
Q
A
R
V
G
I
K
E
L
I
D
E
K
K
--
I
K
-
F
-
V
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
--------------------
Q
--------------------------
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
-
F
G
I
E
G
L
R
--
E
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
----
A
-----
A
E
P
E
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
-
L
C
A
E
Y
D
V
D
--
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
----
I
G
T
P
I
K
R
C
T
P
E
G
-----------------------
V
-----
V
I
E
V
----
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
------
K
-----
S
G
F
E
-
T
M
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
-
N
N
-
R
-
P
-
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
-------------------
G
G
S
------------
M
T
P
F
K
P
--
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
-----------
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
V
L
K
K
G
--------
21
PsiBlast_CBE
96.96
54%
-114
- C1 -
4NWZ
1
?
C:
[3-396]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
LN
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
-
I
-
T
-
T
--
E
--
L
H
Q
P
A
A
G
T
M
H
-
H
--
D
-
Q
A
R
V
G
I
K
E
L
I
D
E
K
K
--
I
K
-
F
-
V
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
--------------------
Q
--------------------------
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
-
F
G
I
E
G
L
R
--
E
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
----
A
-----
A
E
P
E
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
-
L
C
A
E
Y
D
V
D
--
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
----
I
G
T
P
I
K
R
C
T
P
E
G
-----------------------
V
-----
V
I
E
V
----
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
------
K
-----
S
G
F
E
-
T
M
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
-
N
N
-
R
-
P
-
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
-------------------
G
G
S
------------
M
T
P
F
K
P
--
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
-----------
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
V
L
K
K
---------
22
PsiBlast_CBE
96.17
54%
-113
- C1 -
4NWZ
1
?
B:
[3-397]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
LN
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
-
I
-
T
-
T
--
E
--
L
H
Q
P
A
A
G
T
M
H
-
H
--
D
-
Q
A
R
V
G
I
K
E
L
I
D
E
K
K
--
I
K
-
F
-
V
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
--------------------
Q
--------------------------
N
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
-
F
G
I
E
G
L
R
--
E
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
----
A
-----
A
E
P
E
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
M
P
E
-
L
C
A
E
Y
D
V
D
--
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
----
I
G
T
P
I
K
R
C
T
P
E
G
-----------------------
V
-----
V
I
E
V
----
D
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
------
K
-----
S
G
F
E
-
T
M
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
-
N
N
-
R
-
P
-
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
-------------------
G
G
S
------------
M
T
P
F
K
P
--
H
I
R
G
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
-----------
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
V
L
K
K
G
--------
2
PsiBlast_PDB
70.85
26%
-98
- C1 -
4G9K
1
NDI1_YEAST
A:
[11-454]
----------
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
N
V
S
I
I
--
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--------------------
K
-----
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LP
K
-----
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
-
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
L
L
A
K
-----------------------
T
----
K
H
E
D
G
----
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
-----
E
Q
N
S
-
S
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
----------
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
F
--------
E
E
N
-----------
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
-----------
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---
S
M
I
L
S
A
R
S
R
L
K
V
F
---
3
PsiBlast_PDB
69.98
26%
-96
- C1 -
4GAP
2
NDI1_YEAST
A:
[11-454]
----------
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
N
V
S
I
I
--
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--------------------
K
-----
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LP
K
-----
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
-
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
LRTA
V
A
K
V
E
E
K
Q
L
L
A
K
-----------------------
T
----
K
H
E
D
G
----
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
-----
E
Q
N
S
-
S
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
----------
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
F
--------
E
E
N
-----------
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
-----------
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---
S
M
I
L
S
A
R
S
R
L
K
V
F
---
4
PsiBlast_PDB
69.69
26%
-98
- C1 -
4GAV
2
NDI1_YEAST
A:
[11-454]
----------
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
N
V
S
I
I
--
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--------------------
K
-----
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LP
K
-----
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
-
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
RTA
V
A
K
V
E
E
K
Q
L
L
A
K
-----------------------
T
----
K
H
E
D
G
----
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
-----
E
Q
N
S
-
S
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
----------
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
F
--------
E
E
N
-----------
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
-----------
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---
S
M
I
L
S
A
R
S
R
L
K
V
F
---
49
Fugue
69.39
28%
-103
- C1 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
H
S
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
--
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQ
A
-----
E
--------------------
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
----
N
L
LPKG
D
P
E
-
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
L
R
K
F
L
P
A
L
--
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
----
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
EDG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
------
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
---------
A
-
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
-------------------
I
P
N
FQK
I
D
L
L
F
E
E
N
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
GK
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
K
GL
7
PsiBlast_PDB
68.85
26%
-95
- C1 -
4G73
9
NDI1_YEAST
A:
[42-485]
----------
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
N
V
S
I
I
--
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--------------------
K
-----
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LP
K
-----
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
-
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
RTA
V
A
K
V
E
E
K
Q
L
L
A
K
-----------------------
T
----
K
H
E
D
G
----
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
-----
E
Q
N
S
-
S
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
----------
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
P
N
F
Q
K
N
L
S
SRKDK
I
D
L
L
F
E
E
N
-----------
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
-----------
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---
S
M
I
L
S
A
R
S
R
L
K
V
F
---
6
PsiBlast_PDB
68.50
26%
-92
- C1 -
4G6H
5
NDI1_YEAST
A:
[42-485]
----------
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
N
V
S
I
I
--
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--------------------
K
-----
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LP
K
-----
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
-
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
RTA
V
A
K
V
E
E
K
Q
L
L
A
K
-----------------------
T
----
K
H
E
D
G
----
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
-----
E
Q
N
S
-
S
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
----------
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQKNLSSRKDK
I
D
L
L
F
E
E
N
-----------
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
-----------
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---
S
M
I
L
S
A
R
S
R
L
K
V
F
---
8
PsiBlast_PDB
68.28
26%
-92
- C1 -
4G74
10
NDI1_YEAST
A:
[42-485]
----------
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
N
V
S
I
I
--
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--------------------
K
-----
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LP
K
-----
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
-
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
RTA
V
A
K
V
E
E
K
Q
L
L
A
K
-----------------------
T
----
K
H
E
D
G
----
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
-----
E
Q
N
S
-
S
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
----------
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQDK
I
D
L
L
F
-------
E
E
N
-----------
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
-----------
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---
S
M
I
L
S
A
R
S
R
L
K
V
F
---
5
PsiBlast_PDB
67.26
26%
-95
- C1 -
4G6G
8
NDI1_YEAST
A:
[42-485]
----------
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
Y
N
V
S
I
I
--
S
P
R
S
Y
F
L
-
F
-
T
-
P
--
L
--
L
P
S
A
P
V
G
T
V
D
-
E
--
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--------------------
K
-----
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
I
P
G
V
T
--
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LP
K
-----
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
F
-
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
RTA
V
A
K
V
E
E
K
Q
L
L
A
K
-----------------------
T
----
K
H
E
D
G
----
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
-----
E
Q
N
S
-
S
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
----------
G
-
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
F
--------
E
E
N
-----------
N
F
K
P
F
K
Y
--
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
-----------
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---
S
M
I
L
S
A
R
S
R
L
K
V
F
---
33
HHSearch
56.82
22%
-94
- C1 -
3NTD
2
?
A:
[1-338]
----------
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
--
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
-
F
-
A
-
N
C-
G
--
L
P
Y
H
I
S
G
E
I
A
-
Q
R
-
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
--
V
E
-
V
R
V
K
H
-
E
V
V
A
I
D
R
A
A
K
L
V
T
V
--------------------
R
RLLDG
S
--------------------
E
Y
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
-
P
P
I
P
G
V
D
N-
P
L
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
Q
M
--------------------
N
N
V
E
H
A
T
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
H
H
L
----------------
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
----
L
G
T
A
L
S
E
V
S
-
Y
Q
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
----
L
T
L
S
N
------
G
-
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
-----
D
-----
A
G
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
-
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
-
T
G
-
Q
A
C
-
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
R
--------------------------------------------------------------------------------------------------------------------
31
HHSearch
54.96
26%
-112
- C1 -
1XHC
1
?
A:
[9-302]
-----------
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
Q
-----
T
Y
E
V
T
V
I
D
K
E
P
V
P
Y
-
Y
S
K
-
P
--
M
--
L
S
H
Y
I
A
G
F
I
P
-
R
--
N
-
R
L
F
P
Y
S
L
D
W
Y
R
K
R
G
--
I
E
-
I
-
R
L
A
E
E
A
K
L
I
D
R
G
R
K
V
V
I
T
--------------------
E
--------------------------
K
G
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
-
P
Q
I
K
G
K
---
E
Y
L
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
E
----------------------
N
S
G
E
A
I
I
I
G
G
G
F
I
G
L
E
L
A
G
N
L
A
E
A
----------------
G
Y
H
V
K
L
I
H
R
G
A
M
F
L
--
G
-
L
-
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
----
L
N
S
E
L
L
E
A
N
-
E
E
-----------------------
G
----
V
L
T
N
-------
S
-
G
F
I
E
G
K
V
K
I
C
A
I
G
I
V
P
N
V
D
L
A
------
R
R
----
S
G
I
H
-
T
G
R
G
-
I
L
I
D
D
N
F
R
T
-
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
S
G
--------
I
-
I
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
E
--------------------------------------------------------------------------------------------------------------------
37
HHSearch
53.69
25%
-98
- C1 -
3ICS
2
?
A:
[35-353]
---------
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
--
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
-
F
-
A
-
N
C-
G
--
L
P
Y
Y
I
G
G
V
I
T
-
E
RQ
K
-
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
--
L
D
-
I
R
V
L
S
-
E
V
V
K
I
N
K
E
E
K
T
I
T
I
--------------------
K
-----
N
VTTN
E
---------------
T
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
-
P
S
I
P
G
I
E
EA
K
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
--------------------
K
K
P
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
R
----------------
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
----
F
E
D
G
V
D
A
L
E
-
E
N
-----------------------
G
A
V
--
V
R
L
K
S
------
G
-
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
------
K
G
----
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
-
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
-
T
E
-
T
E
T
-
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
--------------------------------------------------------------------------------------------------------------------
42
HHSearch
52.92
21%
-95
- C1 -
3LXD
1
?
A:
[8-321]
---------
E
R
A
D
V
V
I
V
G
A
G
H
G
G
A
Q
A
A
I
A
L
R
Q
N
--
G
F
E
G
R
V
L
V
I
G
R
E
P
E
I
P
-
Y
-
E
-
R
PP
L
--
S
K
E
Y
L
A
R
E
K
T
-
F
--
E
-
R
I
C
I
R
P
A
Q
F
W
E
D
K
A
--
V
E
-
M
-
K
L
G
A
E
V
V
S
L
D
P
A
A
H
T
V
K
L
--------------------
G
-----
D
--------------------
G
S
A
I
E
Y
G
K
L
I
W
A
T
G
G
D
P
R
R
-
L
S
C
V
G
A
D
L
-
A
G
V
H
A
V
R
T
K
E
D
A
D
R
L
M
A
E
L
D
A
---------------------
G
A
K
N
A
V
V
I
G
G
G
Y
I
G
L
E
A
A
A
V
L
T
K
F
----------------
G
V
N
V
T
L
L
E
A
L
P
R
V
L
A
-
R
-
V
A
G
E
A
L
S
E
F
Y
Q
A
E
H
R
A
H
G
V
D
L
R
----
T
G
A
A
M
D
C
I
E
-
G
D
GTKVT------------------
G
----
V
R
M
Q
D
------
G
-
S
V
I
P
A
D
I
V
I
V
G
I
G
I
V
P
C
V
G
A
L
I
-----
S
-----
A
G
A
S
--
G
G
N
G
V
D
V
D
E
F
C
R
T
-
S
L
T
D
V
Y
A
I
G
D
C
A
A
H
A
N
D
F
A
D
G
-
A
V
I
-
R
L
E
S
V
Q
N
A
N
D
M
A
T
A
A
A
K
D
I
C
G
A
--------------------------------------------------------------------------------------------------------------------
27
HHSearch
52.05
21%
-107
- C1 -
3KLJ
1
NROR_CLOAB
A:
[8-294]
---------
K
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
G
K
----
C
D
D
I
T
M
I
N
S
E
K
Y
L
P
Y
Y
-
R
-
P
--
R
--
L
N
E
I
I
A
K
N
K
S
-
I
--
D
-
D
I
L
I
K
K
N
D
W
Y
E
K
N
N
--
I
K
-
V
-
I
T
S
E
F
A
T
S
I
D
P
N
N
K
L
V
T
L
--------------------
K
-----
S
--------------------
G
E
K
I
K
Y
E
K
L
I
I
A
S
G
S
I
A
N
K
-
I
K
V
P
H
A
D
---
E
I
F
S
L
Y
S
Y
D
D
A
L
K
I
K
D
E
C
K
----------------------
N
K
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
I
D
S
----------------
G
T
P
A
S
I
G
I
I
L
E
Y
P
L
E
R
Q
-
L
-
D
R
D
G
G
L
F
L
K
D
K
L
D
R
L
G
I
K
I
Y
----
T
N
S
N
F
E
E
M
G
--------------------------------------------
D
L
I
R
S
S
C
V
I
T
A
V
G
V
K
P
N
L
D
F
I
------
K
D----
T
E
I
A
--
S
K
R
G
I
L
V
N
D
H
M
E
T
-
S
I
K
D
I
Y
A
C
G
D
V
A
E
F
Y
G
--------
K
-
N
P
G
L
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
E
--------------------------------------------------------------------------------------------------------------------
39
HHSearch
51.37
24%
-92
- C1 -
3IWA
1
?
A:
[4-348]
-----------
K
H
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
F
K
R
L
--
D
P
E
A
H
V
T
M
I
D
Q
A
-----------------------------------------------
V
E
A
L
-
V
E
T
-
R
A
H
A
I
D
R
A
A
H
T
V
E
I
--------------------
E
-----
N
LRTG
E
---------------
R
R
T
L
K
Y
D
K
L
V
L
A
L
G
S
K
A
N
R
-
P
P
V
E
G
M
D
L-
A
G
V
T
P
V
T
N
L
D
E
A
E
F
V
Q
H
A
I
S
A
--------------------
G
E
V
S
K
A
V
I
V
G
G
G
F
I
G
L
E
M
A
V
S
L
A
D
M
W
---------------
G
I
D
T
T
V
V
E
L
A
D
Q
I
M
P
-
G
-
F
T
S
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
D
V
V
V
H
----
T
G
E
K
V
V
R
L
E
-
G
E
-----------------------
N
GKVA
R
V
I
T
D
------
K
-
R
T
L
D
A
D
L
V
I
L
A
A
G
V
S
P
N
T
Q
L
A
R
-----
D
-----
A
G
L
E
L
D
P
R
G
A
I
I
V
D
T
R
M
R
T
-
S
D
P
D
I
F
A
G
G
D
C
V
T
I
P
N
L
V
-
T
G
-
K
P
G
-
F
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
L
A
D
G
--------------------------------------------------------------------------------------------------------------------
29
HHSearch
50.62
20%
-96
- C1 -
2GQW
5
?
A:
[6-309]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
--
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
-
Y
-
D
R
P
--
P
--
L
S
K
D
F
M
A
H
G
D
-
A
--
E
-
K
I
R
L
D
---
C
K
R
A
P
E
--
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
--------------------
S
-----
D
--------------------
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
--
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
----------------------
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
----------------
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
-
R
A
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
----
F
E
R
S
V
T
G
S
V
-
D
G
-----------------------
V
----
V
L
L
D
D
------
G
-
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
------
R
A
----
A
G
L
A
--
C
D
D
G
I
F
V
D
A
Y
G
R
T
-
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
-
R
-
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
-------------------------------------------------------------------------------------------------------------------
35
HHSearch
50.30
20%
-97
* C1 *
3FG2
2
?
P:
[1-337]
----------
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
--
K
Y
P
G
R
I
A
L
I
N
D
E
K
H
L
P
-
Y
-
Q
-
R
--
P
PL
S
K
A
Y
L
K
S
G
G
D
-
P
--
N
-
S
L
M
F
R
P
E
K
F
F
Q
D
Q
A
--
I
E
-
L
-
I
S
D
-
R
M
V
S
I
D
R
E
G
R
K
L
L
L
--------------------
A
-----
S
--------------------
G
T
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
-
L
D
V
P
N
A
S
L-
P
D
V
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
----------------------
P
D
K
K
H
V
V
V
I
G
A
G
F
I
G
L
E
F
A
A
T
A
R
A
K
----------------
G
L
E
V
D
V
V
E
L
A
P
R
V
M
A
-
R
V
V
-
T
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
----
Y
G
V
R
A
T
E
I
A
-
A
E
GDRVT------------------
G
----
V
V
L
S
D
------
G
-
N
T
L
P
C
D
L
V
V
V
G
V
G
V
I
P
N
V
E
I
A
A-----
A
-----
A
G
L
P
-
T
-
A
A
G
I
I
V
D
Q
Q
L
L
T
-
S
D
P
H
I
S
A
I
G
D
C
A
L
F
E
S
V
R
-
F
G
-
E
T
M
-
R
V
E
S
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
D
A
K
-------------------
P
Y
D
------------
G
Y
P
W
F
W
SD
Q
G
D
D
K
L
Q
I
V
G
L
T
A
G
----------------------------------------------------------
34
HHSearch
48.49
20%
-96
- C1 -
1NHP
3
NAPE_ENTFA
A:
[1-317]
-----------
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
--
H
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
-
F
-
L
-
S
A-
G
--
M
Q
L
Y
L
E
G
K
V
K
D
V
--
N
-
S
V
R
Y
M
T
G
E
K
M
E
S
R
G
--
V
N
-
V
-
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
--------------------
K
-----
D
LVSG
E
---------------
E
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
-
L
D
I
P
G
K
D
L-
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
--------------------
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
----------------
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
-
L
-
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
----
T
G
E
T
V
E
R
Y
E
-
G
D
-----------------------
G
RVQ-
K
V
V
T
D
------
K
-
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
------
K
-----
G
T
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
-
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
-
A
D
T
E
-
V
-
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-------------------------------------------------------------------------------------------------------------------