@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2403: (2016-04-03 )
LMKHLTLWHTNDVHSHLEHWPRIFNFLKEKRTAADKENQSALFFDIGDFLDRVHPLTEGTNGLANTDLLNQLPYDVVTFGNNEGTTLAHEDLDKLYEHAVFPVVCCNFYTNKECTEQPDWVKSIVYKEIEQVKIAIIGATAPFRDYYEEMGWGIEEPISSIKKQVAGLDEDTDVVILLSHLGLPSDERIALEIPEVDVILGGHTHHLLETGKIEGNALLAAAGRWGEYIGKVDIELDENNQILTKTAMTFKTEDLPAAPNEANEIQGFFDKGRAELSEKVVAIPGKLAHNWFDDSEIAHILNEAVCEWTGAETFVMNAGIFMTDFEAGIVTDFDIHQMLPHPLNAIALTMSGEELEILIDGIYRKKAELQDIPLRGFGFRGEYFGTVLMERAGFDAENQVALFDNKPIDKTREYRIATHDTFVFAPFFPIVKQIKRKEVYTPELLRDILKWKLKKMYGQEEDK
Atome Classification :
(20 SA)
-------------------------------------------------....---------.....10.......---------------.---------------20-----------------....--.--------------...30....-------....40........50........60.......---------.70........80...----.....90........100.....-..110.......120.....--..130......--.140-----.------..------..----.-----.---.----150.----.--.....160.......--170-........180----------...----------------.-------------...190..--.....200......--------.210----------------...-------------------....---------.220---------..---------.....230....-.------------------------------------.------.240...---....-.250-.--.--.----------......260....------...----270---........280-.......----290---..--------......300.....----------..-----310...--......320---.......330.......340.......350.......360.......370.......-380.......390.....--------...400..----.----....410.......420.-----..-....430.......440.......450..---------.....460.----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------LM
K
H
---------
L
T
L
W
HT
N
D
V
H
S
H
L
E
---------------
H
---------------
W
P
-----------------
R
I
F
N
--
F
--------------
L
K
E
K
RTAAD-------KENQ
S
A
L
F
F
D
I
G
D
F
L
D
R
VHPLTEGTNGLAN
T
D
L
---------
L
N
QLPY
D
V
V
T
FGNNEG----TT
L
A
H
E
D
L
D
K
L
Y
E
HAV
F
P
V
V
C
CN-FYTNKECTEQ
P
D
W
V
K
S
I
V
Y
K
--
E
I
E
Q
V
K
I
A
I
I
G--ATA------
P
------
F
R
------
D
Y
----
Y
-----
E
---
E
----MGWG----
I
--
E
E
P
I
S
S
I
K
K
Q
VAGLD--E-D-T
D
V
V
I
L
L
S
HLG----------LPS----------------D-------------
E
R
I
A
L
EIP--
E
V
D
V
I
LGGH
T
H
H
L
L
--------ETG-----------------KIE-------------------G
N
A
L
---------
L
A
AA---------GR---------WGE
Y
I
G
K
V
D
I
E
L-D------------------------------------E------NN
Q
-
I
L
T
---
K
T
A
M
-
T
F
---K--T--E----------DLPAAPNE
A
N
E
I
Q
------
G
F
F
----
D
K
----
G
R
A
E
L
S
E
K
V
V
A-I
P
G
K
L
A
H----NW----F
D
--------
D
S
E
I
A
H
I
L
N
E
A
V
C
E----------WT-----G--A
E
T
--
F
V
M
NA
G
I
F
M
---
T
DFEAG
I
V
TDF
D
I
H
Q
MLPHPL
N
A
I
A
L
T
MSGE
E
L
E
I
L
I
D
G
I
Y
RKKAELQDIPLRGFGF-R
G
E
Y
F
G
T
V
L
M
E
-RAGFDA--------EN
Q
V
A
LFD----N----KPIDKTR
E
Y
R
I
ATH
D
T
F
V
-----FA-
P
F
F
P
I
V
K
Q
I
K
RKEVY
T
P
E
L
L
R
D
I
L
K
W
K
L
K
---------
K
M
YGQEEDK----------
23
HHSearch
96.64
21%
-86
- C2 -
2Z1A
4
?
A:
[28-522]
---------------------------------------------------
F
T
---------
L
T
L
V
H
T
N
D
T
H
A
H
L
E
---------------
P
V
E
L
T
L
SG
E
K
T
P
V
G
G-
V
A
-----------------
R
R
V
A
--
L
--------------
F
D
R
V
W
A
R
-----------
A
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
-
L
Y
F
N
Q
Y
R
G
L
A
D
R
Y
F
---------
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
-----
F
D
L
G
P
G
P
L
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
-
V
D
A
S
R
E
P
-
R
L
K
G
L
F
A
P
Y
A
V
V
--
V
V
G
G
E
R
V
G
I
I
G
--
L
T
T
------
P
------
D
T
------
R
E
----
I
-----
S
---
N
PG--
P
T
V
A
----
F
--
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
-
G
-
V
N
K
I
V
V
L
S
H
L
G
----------
Y
G
E
----------------
D
-------------
L
K
L
A
R
R
L
V
--
G
V
Q
V
I
V
G
G
H
S
H
T
L
L
--------
G
S
F
PHKELSPAGPY
P
T
V
V
K
N
P
E
G
-------------------
K
D
V
L
---------
V
V
Q
A
---------
W
E
---------
W
G
K
V
V
G
L
L
E
V
T
F
-
D
------------------------------------
A
------
K
G
E
-
L
L
A
---
Y
K
G
E
-
A
L
---
L
--
M
--
T
PE--------
A
A
P
E
D
F
F
A
K
E
A
L
L
------
A
Y
A
----
Q
P
----
V
M
A
L
M
Q
Q
V
I
A
E
-
A
K
V
D
L
V
G
ERAV
V
R
----
R
R
--------
E
S
N
L
G
N
L
I
T
D
G
M
L
W
----------
K
T
R
NA--
G
--
T
Q
I
--
A
L
Q
N
G
G
G
I
R
---
A
S
I
P
K
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
--
S
Q
W
E
N
------------
T
A
G
R
F
L
Q
V
S
-
G
L
R
Y
A
F
D
LSRPAGS
R
V
V
R
V
E
V
K
T
EKG
Y
----
V
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
-----
N
G
G
D
G
F
T
V
L
K
E
A
Q
G
Y
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
---------
E
L
K
V
V
E
A
------------
21
HHSearch
96.62
21%
-88
- C2 -
3IVE
5
?
A:
[4-489]
--------------------------------------------------
A
K
D
---------
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
---------------
P
Y
K
V
PWIADGKRDIGG
W
A
-----------------
N
I
T
T
--
L
--------------
V
K
Q
E
K
A
K
-----------
N
K
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
-
Y
I
S
S
L
T
K
G
K
A
I
I
D
I
---------
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
-----
F
D
H
G
W
D
N
T
L
L
Q
L
S
Q
A
K
F
P
I
V
Q
G
N
-
I
F
Y
Q
N
S
S
--
K
S
F
W
D
K
P
Y
T
I
I
--
E
K
D
G
V
K
I
G
V
I
G
--
L
H
G
------
V
------
F
A
------
F
N
----
D
TVSAA
T
---
R
----
V
G
I
E
----
A
--
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
-
K
-
V
D
L
T
V
A
L
I
H
E
G
----------
V
P
A
----------------
R
QSSMD
V
R
R
A
L
D
K
D
I
Q
T
A
S
Q
V
K
--
G
L
D
I
L
I
T
G
H
A
H
V
G
T
--------
P
E
P
-----------------
I
K
V
-------------------
G
N
T
L
---------
I
L
S
T
---------
D
S
---------
G
G
I
D
V
G
K
L
V
L
D
Y
-
K
------------------------------------
E
------
K
P
H
N
F
T
V
---
K
N
F
E
-
L
K
---
T
I
Y
A
--
D
----------
E
W
K
P
D
Q
Q
T
K
Q
V
I
D
------
G
W
N
----
K
K
----
L
D
E
V
V
Q
Q
T
V
A
Q
-
S
P
V
E
L
K
R
----
A
Y
----
G
E
--------
S
A
S
L
G
N
L
A
A
D
A
L
L
A
----------
A
A
-----
G
KN
T
Q
L
--
A
L
T
N
S
G
G
I
R
---
N
E
I
P
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
--
S
L
S
----------------
N
G
V
L
Q
V
S
K
G
L
E
M
K
Y
D
SSKPVGQ
R
V
I
T
L
T
L
N
----
G
----
K
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
-----
D
G
G
D
G
F
T
A
F
T
E
G
K
A
R
N
I
T
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
---------
A
G
N
T
I
T
D
------------
22
HHSearch
88.69
21%
-80
- C2 -
1HP1
7
USHA_ECOLI
A:
[6-504]
--------------------------------------------------
T
Y
K
---------
I
T
V
L
H
T
N
D
H
H
G
H
F
W
---------------
R
NEYGEYG--------
L
A
-----------------
A
Q
K
T
--
L
--------------
V
D
G
I
R
K
E
V
A
-------
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-----
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
Q
K
S
T
G
---
E
R
L
F
K
P
W
A
L
F
--
K
R
Q
D
L
K
I
A
V
I
G
--
L
T
T
------
D
------
D
T
------
A
K
----
I
-----
G
---
N
PEYF
T
D
I
E
----
F
--
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
----------
H
Y
D
NGEHGSNAPG------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
--------
C
M
A
AENKKQVDYVPG
T
P
C
K
P
D
Q
Q
-------------------
N
G
I
W
---------
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
------
G
E
M
--
K
M
---
V
N
Y
Q
-
L
I
---
P
--
V
--
N
LKKKRVLYTP
E
I
A
E
N
Q
Q
M
I
S
L
L
S
------
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
--
Q
M
K
P
-------------
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
DG-----
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
-----
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
---------
K
S
S
P
L
D
V
------------
11
PsiBlast_PDB
86.61
21%
-80
- C2 -
1OI8
4
USHA_ECOLI
A:
[9-470]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
----------
N
T
G
V
C
E
S
D
L
Q
DA
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
------
D
------
D
T
AKIGNP
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
G
E
M
K
M
V
N
Y
Q
-
L
I
P
VN
L
K
K
K
V
-
T
W
EDG
K
--
S
--
E
----------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
DKVR
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
3
PsiBlast_PDB
86.38
21%
-77
- C2 -
1HP1
7
USHA_ECOLI
A:
[9-461]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
DDTAKI
G
------
N
P
------
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
G
E
M
K
M
V
N
Y
Q
-
L
I
P
VNL
K
K
K
R
-
V
L
---
Y
--
T
--
P
----------
E
I
A
E
N
Q
Q
M
I
S
L
L
S
------
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
D
K
V
R
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
4
PsiBlast_PDB
85.44
21%
-74
- C2 -
4WWL
15
USHA_ECOLI
A:
[9-470]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
DD
T
A
K
I
G
------
N
P
------
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
G
E
M
K
M
V
N
Y
Q
-
L
I
P
VN
L
K
K
K
V
-
T
W
EDG
K
--
S
--
E
----------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
DKVR
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
1
PsiBlast_PDB
85.39
23%
-70
- C2 -
3IVD
4
?
A:
[3-393]
-------------------------------------------------
L
A
K
D
---------
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
PWIADGKRDIG
G
---------------
W
A
-----------------
N
I
T
T
--
L
--------------
V
K
Q
E
K
A
-----------
K
N
K
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
Y
-
I
S
S
L
T
K
G
K
A
I
I
D
I
---------
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
----
D
H
G
W
D
N
T
L
L
Q
L
-
S
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
N
---
S
S
K
S
F
W
D
K
P
Y
T
I
I
--
E
K
D
G
V
K
I
G
V
I
G
L
H
G
V
F
------
A
------
F
N
------
D
T
----
V
-----
S
AAT
R
----
V
G
I
E
----
A
--
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
-
K
-
V
D
L
T
V
A
L
I
H
E
G
----------
V
P
A
RQSSMGGTD
V
R
R
A
L
D
K
D
-------------
I
Q
T
A
S
Q
V
K
--
G
L
D
I
L
I
T
G
H
A
H
V
G
T
--------
P
E
P
-----------------
I
K
V
-------------------
G
N
T
L
---------
I
L
S
T
---------
D
S
---------
G
G
I
D
V
G
K
L
V
L
D
Y
-
K
------------------------------------
E
------
K
P
H
-
N
F
T
---
V
K
N
F
-
E
L
---
K
--
T
I
Y
A
----------
D
E
W
K
P
D
Q
Q
T
K
Q
V
I
------
D
G
W
----
N
K
----
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
K
R
----
A
Y
----
G
E
--------
S
A
S
L
G
N
L
A
A
D
A
L
L
A
----------
A
A
-----
G
--
K
N
T
Q
L
A
L
T
N
S
G
G
I
R
---
N
E
I
P
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.12
21%
-74
- C2 -
1HPU
3
USHA_ECOLI
A:
[9-470]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
------
D
DTAKIG
N
P
------
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
GEMKMV
N
Y
Q
-
L
I
P
VN
L
K
K
K
V
-
T
W
EDG
K
--
S
--
E
----------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
DKVR
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
5
PsiBlast_PDB
85.01
21%
-77
- C2 -
1OID
1
USHA_ECOLI
A:
[9-470]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
------
D
------
D
T
AKIGNP
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGCN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
G
E
M
K
M
V
N
Y
Q
-
L
I
P
VN
L
K
K
K
V
-
T
W
EDG
K
--
S
--
E
----------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
D
K
V
R
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
9
PsiBlast_PDB
84.53
21%
-71
- C2 -
1HO5
4
USHA_ECOLI
A:
[9-470]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
------
D
DTAKIG
N
P
------
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
GEMKMV
N
Y
Q
-
L
I
P
VN
L
K
K
K
V
-
T
W
EDG
K
--
S
--
E
----------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
DKVR
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
6
PsiBlast_PDB
84.32
21%
-77
- C2 -
1OIE
1
USHA_ECOLI
A:
[9-470]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
------
D
------
D
T
AKIGNP
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGCN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
G
E
M
K
M
V
N
Y
Q
-
L
I
P
VNL
K
K
K
V
---------
S
--
E
----------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
D
K
V
R
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
8
PsiBlast_PDB
84.10
21%
-76
- C2 -
1USH
7
USHA_ECOLI
A:
[34-495]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
DDTAKI
G
------
N
P
------
E
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
G
E
M
K
M
V
N
Y
Q
-
L
I
P
VNL
K
K
-------------------------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
D
K
V
R
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
D
G
--------
K
L
N
D
L
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
7
PsiBlast_PDB
83.02
21%
-80
- C2 -
2USH
7
USHA_ECOLI
A:
[34-495]
--------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------
W
R
-----------------
N
E
Y
G
EY
G
--------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
---------
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
DNP
L
T
V
L
R
Q
Q
E
-----
K
W
A
K
F
P
L
L
S
A
N
-
I
Y
--
Q
K
S
T
G
E
R
L
F
K
P
W
A
L
F
K
--
R
-
Q
D
L
K
I
A
V
I
G
--
L
T
T
DDTAK-----------------
Y
----
F
-----
T
---
D
----
I
E
F
--------
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
----------------
D
-------------
V
E
M
A
R
A
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAENKK
Q
V
D
-----------------
Y
V
P
-------------------
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
---------
H
E
---------
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
------------------------------------
N
G
E
M
K
M
V
N
Y
Q
-
L
I
P
VN
L
K
K
K
V
---------
S
--
E
----------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
----
N
K
----
G
K
A
Q
L
E
V
K
I
G
E
-
T
N
G
R
L
E
G
----
D
R
DKVR
F
V
--------
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
----------
R
T
-----
G
--
A
D
F
--
A
V
M
S
G
G
G
I
R
---
D
S
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
------------
S
G
A
Y
P
Q
F
A
N
V
S
-
F
V
A
K
---------------
K
I
K
----
G
----
E
P
V
D
P
A
K
T
Y
R
M
A
T
----------------------------------------------------------------------
43
Fugue
81.37
17%
-68
- C2 -
2WDC
18
?
A:
[21-562]
YDLPPYGDATLLYFSDLHGQA
F
P
H
Y
F
M
E
P
PNLIAPKPLMGRPGYLTG
E
A
I
L
R
Y
Y
GVERGT
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
---------------
T
FGPIGG---------
M
G
-----------------
A
L
T
A
--
L
--------------
I
R
D
Q
K
A
R
V
E
-------
A
E
G
G
K
A
L
V
L
D
G
G
D
T
W
-
T
N
S
G
L
S
L
L
T
R
G
E
A
V
V
R
W
---------
Q
N
L
V
G
V
D
H
M
V
--
S
H
W
E
----
W
T
L
G
R
E
R
V
E
E
L
L
G
L
F
R
G
E
F
L
S
Y
N
-
I
V
D
D
L
F
---
G
D
P
L
F
P
A
Y
R
I
H
--
R
V
G
P
Y
A
L
A
V
V
G
--
A
S
Y
------
P
------
Y
V
------
K
V
SHPE
S
-----
F
---
T
----
E
G
L
S
----
F
--
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
--
A
-
E
G
A
N
A
V
V
L
L
S
H
N
G
----------
M
Q
L
----------------
D
-------------
A
A
L
A
E
R
I
R
--
G
I
D
L
I
L
S
G
H
T
H
D
L
T
--------
P
R
P
-----------------
W
R
V
-------------------
G
K
T
W
---------
I
V
A
G
---------
S
A
---------
A
G
K
A
L
M
R
V
D
L
K
L
W
K
------------------------------------
G
------
G
I
A
-
N
L
R
---
V
R
V
L
-
P
V
---
L
--
A
--
E
----------
H
L
P
K
A
E
D
V
E
A
F
L
K
------
A
Q
L
----
A
P
----
H
Q
D
H
L
F
T
P
L
A
V
-
S
E
T
L
L
Y
K
----
R
D
----
T
L
--------
Y
S
T
W
D
Q
L
V
G
E
A
V
K
A
----------
I
Y
-----
P
--
E
V
E
--
V
V
F
S
P
A
V
R
W
G
T
T
I
L
P
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
D
I
A
S
N
V
F
T
S
D
P
F
Y
Q
Q
G
G
D
V
S
R
V
F
G
L
R
Y
V
L
D
P
-
D
A
P
T
G
E
--------
R
V
R
E
V
E
V
G
----
G
----
R
P
L
D
P
N
R
R
Y
L
A
A
A
Y
G
G
--------
R
-
L
Q
R
V
G
E
A
K
P
G
Y
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
V
G
R
V
R
V
R
PEPN
V
K
V
I
G
R
N
Y
R
L
P
EVTG-----
42
Fugue
81.25
19%
-64
- C2 -
3ZTV
4
5NTD_HAEIN
A:
[8-573]
------------------------------------------------H
K
A
V
E
---------
L
S
I
L
H
I
N
D
H
H
S
Y
L
E
---------------
P
---------------
H
E
-----------------
T
R
I
N
--
L
NG
Q
Q
T
K
V
D
I
G
G
F
S
A
V
N
A
K
L
N
K
L
R
-------
K
K
Y
K
N
P
L
V
L
H
A
G
D
A
I
T
G
-
T
L
Y
F
T
L
F
G
G
S
A
D
A
A
V
---------
M
N
A
G
N
F
H
Y
F
T
L
G
N
H
E
F
----
D
A
-
G
N
E
G
L
L
K
L
L
E
P
L
K
I
P
V
L
S
A
N
-
V
I
P
D
K
S
-
S
I
L
Y
N
K
W
K
P
Y
D
I
F
--
T
V
D
G
E
K
I
A
I
I
G
--
L
D
T
------
V
-------
N
------
K
T
----
V
-----
N
---
S
----
S
S
P
G
KD
V
K
F
--
Y
D
E
I
A
T
A
Q
I
M
A
N
A
L
K
--
Q
-
Q
G
I
N
K
I
I
L
L
S
H
A
G
----------
S
E
K
----------------
N
-------------
I
E
I
A
Q
K
V
N
--
D
I
D
V
I
V
T
G
D
S
H
Y
L
Y
--------
G
N
D
-----------------
E
L
R
S
L
KLPVIYEY
P
L
E
F
K
N
PNG
E
P
V
F
---------
V
M
E
G
---------
W
A
---------
Y
S
A
V
V
G
D
L
G
V
K
F
-
S
PEG
I
A
S
I
TRKIP
H
V
L
M
S
SH
K
L
Q
V
K
N
SEG
K
W
A
E
L
T
G
D
E
------
R
K
K
-
A
L
D
---
T
L
K
S
-
M
K
---
S
--
I
--
S
----------
L
D
D
H
D
A
K
T
D
K
L
I
A
------
K
Y
K
----
S
E
----
K
D
R
L
A
Q
E
I
V
G
V
-
I
T
G
S
A
M
P
----
G
G
----
S
A
NRIPNKAG
S
N
P
E
G
S
I
A
T
R
F
I
A
E
----------
T
M
Y
N
E
L
K
T
--
V
D
L
--
T
I
Q
N
A
G
G
V
R
---
A
D
I
L
P
G
N
V
T
F
N
D
A
Y
T
F
L
P
F
G
N
T
L
Y
T
Y
K
M
E
G
S
L
V
K
Q
V
L
E
D
A
M
Q
F
A
L
V
D
G
S
-
T
G
A
F
P
Y
G
-
A
G
I
R
Y
E
A
N
E
T
P
-
N
A
E
G
K
R
--------
L
V
S
V
E
V
L
N
----
K
TQ
Q
W
E
P
I
D
D
N
K
R
Y
L
V
G
T
N
A
Y
V
A
G
GKDG
Y
K
-
T
F
G
K
L
F
N
D
P
K
Y
E
G
V
D
T
Y
L
P
D
A
E
S
F
I
K
F
M
K
---------
K
H
P
H
F
E
A
Y
T
SSN
V
K
F
N
A
ST
17
PsiBlast_PDB
80.56
22%
-73
- C2 -
4H2F
4
5NTD_HUMAN
A:
[26-389]
--------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
---------------
Q
---------------
T
S
EDSSKCVDASR
C
M
G
G
V
A
R
L
F
T
--
K
--------------
V
Q
Q
I
R
R
A
-----------
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
-
Y
K
G
A
E
V
A
H
F
---------
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
----
D
N
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
-
I
K
A
K
G
P
L
A
S
Q
I
S
G
L
Y
-
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
--
Y
T
S
------
K
------
E
T
------
P
F
----
L
-----
S
---
N
----
P
G
T
N
----
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
-
V
N
K
I
I
A
L
G
H
S
G
----------
F
E
M
----------------
D
-------------
K
L
I
A
Q
K
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
--------
Y
T
G
-----------------
N
P
P
-------------------
S
K
E
V
---------
P
A
G
K
YPF
I
V
T
S
DD
G
R
K
V
P
V
V
Q
A
YA
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
------------------------------------
E
------
R
G
N
-
V
I
S
---
S
H
G
N
-
P
I
---
L
--
L
--
D
S---------
S
I
P
E
D
P
S
I
K
A
D
I
N
------
K
W
R
I
K
L
D
D
Y
----
S
T
Q
E
L
G
K
T
I
V
Y
-
L
D
G
S
S
Q
S
----
C
R
----
F
R
--------
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
HADEMF
W
N
-----
H
--
V
S
M
--
C
I
L
N
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.08
22%
-74
- C2 -
4H2I
5
5NTD_HUMAN
A:
[1-367]
--------------------------------------------------
M
W
E
---------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
---------------
Q
---------------
T
S
EDSSKCVDASRCMGG
V
A
R
L
F
T
--
K
--------------
V
Q
Q
I
R
R
A
-----------
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
-
Y
K
G
A
E
V
A
H
F
---------
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
----
D
N
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
-
I
K
A
K
G
P
L
A
S
Q
I
S
G
L
-
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
--
Y
T
S
------
K
------
E
T
------
P
F
----
L
-----
S
---
N
----
P
G
T
N
----
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
-
V
N
K
I
I
A
L
G
H
S
G
----------
F
E
M
----------------
D
-------------
K
L
I
A
Q
K
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
--------
Y
T
G
-----------------
N
P
P
-------------------
S
K
E
V
---------
P
A
G
K
YP
F
I
V
T
S
DD
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
------------------------------------
E
------
R
G
N
-
V
I
S
---
S
H
G
N
-
P
I
---
L
--
L
--
D
S---------
S
I
P
E
D
P
S
I
K
A
D
I
N
------
K
W
R
I
KLD
D
Y
----
S
T
Q
E
L
G
K
T
I
V
Y
-
L
D
G
S
S
Q
S
----
C
R
----
F
R
--------
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
HADEMF
W
N
-----
H
--
V
S
M
--
C
I
L
N
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.06
22%
-77
- C2 -
4H2B
5
5NTD_HUMAN
A:
[27-390]
--------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
---------------
Q
---------------
T
S
EDSSKCVDASR
C
M
G
G
V
A
R
L
F
T
--
K
--------------
V
Q
Q
I
R
R
A
-----------
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
-
Y
K
G
A
E
V
A
H
F
---------
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
----
D
N
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
-
I
S
A
S
G
P
L
A
S
Q
I
S
G
L
Y
-
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
--
Y
T
S
------
K
------
E
T
------
P
F
----
L
-----
S
---
N
----
P
G
T
N
----
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
-
V
N
K
I
I
A
L
G
H
S
G
----------
F
E
M
----------------
D
-------------
K
L
I
A
Q
K
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
--------
Y
T
G
-----------------
N
P
P
-------------------
S
K
E
V
---------
P
A
G
K
YP
F
I
V
T
S
DD
G
R
K
V
P
V
V
Q
A
YA
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
------------------------------------
E
------
R
G
N
-
V
I
S
---
S
H
G
N
-
P
I
---
L
--
L
--
D
S---------
S
I
P
E
D
P
S
I
K
A
D
I
N
------
K
W
R
I
K
L
D
D
Y
----
S
T
Q
E
L
G
K
T
I
V
Y
-
L
D
G
S
S
Q
S
----
C
R
----
F
R
--------
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
LRHADEMF
W
N
-----
H
--
V
S
M
--
C
I
L
N
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.98
22%
-74
- C2 -
4H1S
4
5NTD_HUMAN
A:
[2-367]
---------------------------------------------------
W
E
---------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
---------------
Q
---------------
T
S
EDSSKCVNASRCMGG
V
A
R
L
F
T
--
K
--------------
V
Q
Q
I
R
R
A
-----------
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
-
Y
K
G
A
E
V
A
H
F
---------
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
----
D
N
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
-
I
K
A
K
G
P
L
A
S
Q
I
S
G
L
-
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
--
Y
T
S
------
K
------
E
T
------
P
F
----
L
-----
S
---
N
----
P
G
T
N
----
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
-
V
N
K
I
I
A
L
G
H
S
G
----------
F
E
M
----------------
D
-------------
K
L
I
A
Q
K
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
--------
Y
T
G
-----------------
N
P
P
-------------------
S
K
E
V
---------
P
A
G
K
YP
F
I
V
T
S
DD
G
R
K
V
P
V
V
Q
A
YA
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
------------------------------------
E
------
R
G
N
-
V
I
S
---
S
H
G
N
P
I
L
---
L
--
N
--
S
----------
S
I
P
E
D
P
S
I
K
A
D
I
N
------
K
W
R
----
I
K
L
DNY--
Q
E
L
G
K
T
I
V
Y
-
L
D
G
S
S
Q
S
----
C
R
----
F
R
--------
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
TDEMF
W
N
-----
H
--
V
S
M
--
C
I
L
N
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.69
22%
-77
- C2 -
4H1Y
5
5NTD_HUMAN
P:
[26-389]
--------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
---------------
Q
---------------
T
S
EDSSKCVDASRCMGGVA
R
L
F
T
--
K
--------------
V
Q
Q
I
R
R
A
-----------
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
-
Y
K
G
A
E
V
A
H
F
---------
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
----
D
N
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
-
I
S
A
S
G
P
L
A
S
Q
I
S
G
L
Y
-
L
P
Y
K
VL
P
V
G
D
E
V
V
G
I
V
G
--
Y
T
S
------
K
------
E
T
------
P
F
----
L
-----
S
---
N
----
P
G
T
N
----
L
VF
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
-
V
N
K
I
I
A
L
G
H
S
G
----------
F
E
M
----------------
D
-------------
K
L
I
A
Q
K
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
--------
Y
T
G
-----------------
N
P
P
-------------------
S
K
E
V
---------
P
A
G
K
YPFIVTSDD
G
R
KVPVVQAYA
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
------------------------------------
E
------
R
G
N
-
V
I
S
---
S
H
G
N
-
P
I
---
L
--
L
--
D
S---------
S
I
P
E
D
P
S
I
K
A
D
I
N
------
K
W
R
IKLD
D
Y
----
S
T
Q
E
L
G
K
T
I
V
Y
-
L
D
G
S
S
Q
S
----
C
R
----
F
R
--------
E
C
N
M
G
N
L
I
C
D
A
M
I
N
NNLRHADEMF
W
N
-----
H
--
V
S
M
--
C
I
L
N
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------