@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2415: (2016-04-03 )
MATLKIQDLHVEIEGKEILKGVNLEISTGEIHAIMGPNGTGKSTLSSAIMGHPKYEVTQGTITLDGEDVLEMEVDERARAGLFLAMQYPSEISGVTNAEFIRAAINSRREEGDEIPVMQFIRKLDAKMDILDMDEEMAERYLNEGFSGGEKKRNEILQLLMIEPKLAILDEIDSGLDIDALKVVSKGVNEMRGEGFGCLIITHYQRLLNYITPDFVHVMMQGKVVKEGGPELAKRLEAEGYDWIKQELGIELEEEEAVDQQ
Atome Classification :
(20 SA)
.........10....-....20........30........40........50-----........60........70------------------.--...------------...-------.80........90........100...----..-..-------110..-.-...-----.120.......130......-.140.......150.......160-.......170.......180.......190-.-......200.......210.......220.......-230.......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
T
L
K
I
Q
D
L
H
V
E
IE
G
-
K
E
ILKGV
N
L
E
I
STG
E
I
H
A
I
MGPNGT
G
K
S
T
L
S
S
A
IMG-----HPK
Y
E
V
T
Q
G
T
I
T
LDG
E
D
V
L
E
------------------
M
--
E
V
D
------------
E
RA-------RA
G
L
F
L
A
M
QY
P
S
E
ISGV
T
N
A
E
F
I
R
A
A
I
----
N
S
-RR-------EEGDE-I-
P
V
M
-----
Q
F
I
R
K
LDAKMDILDM
D
E
E
M
A
-
E
R
Y
L
NEGFSG
G
E
K
K
R
N
E
I
L
Q
L
L
MI-E
P
K
L
A
I
L
D
EIDSGL
D
I
D
A
L
K
V
V
S
K
G
V
N
E
M
R-G-EG
F
G
C
L
I
I
T
H
Y
Q
R
L
L
N
YI
T
P
D
F
V
H
V
M
MQG
K
V
VKEG
G
-
P
E
L
A
K
R
LEAE
G
Y
D
W
I
K
Q
E
LG
I
E
LE
E
E
EAVDQQ
55
HHSearch
96.92
61%
-112
- C1 -
2D2E
3
?
A:
[2-245]
-
S
Q
L
E
I
R
D
L
W
A
S
I
D
G
-
E
T
I
L
K
G
V
N
L
V
V
P
K
G
E
V
H
A
L
M
G
P
N
G
A
G
K
S
T
L
G
K
I
L
A
G
-----
D
P
E
Y
T
V
E
R
G
E
I
L
L
D
G
E
N
I
L
E
------------------
L
--
S
P
D
------------
E
R
A
-------
R
K
G
L
F
L
A
F
Q
Y
P
V
-
V
P
G
V
T
I
A
N
F
L
R
L
A
L
----
Q
A
-
K
L
-------
G
R
--
E
-
V
-
G
V
A
-----
E
F
W
T
K
V
K
K
A
L
E
L
L
D
W
D
E
S
Y
L
-
S
R
Y
L
N
E
----
G
E
K
K
R
N
E
I
L
Q
L
L
V
L
-
E
P
T
Y
A
V
L
D
E
T
D
S
G
L
D
I
D
A
L
K
V
V
A
R
G
V
N
A
M
R
-
G
-
P
N
F
G
A
L
V
I
T
H
Y
Q
R
I
L
N
Y
I
Q
P
D
K
V
H
V
M
M
D
G
R
V
V
A
T
G
G
-
P
E
L
A
L
E
L
E
A
K
G
Y
E
W
L
K
E
K
--------------
2
PsiBlast_PDB
96.61
60%
-108
- C1 -
2D2F
5
?
A:
[2-246]
-
S
Q
L
E
I
R
D
L
W
A
S
I
D
G
-
E
T
I
L
K
G
V
N
L
V
V
P
K
G
E
V
H
A
L
M
G
P
N
G
A
G
K
S
T
L
G
K
I
L
A
G
-----
D
P
E
Y
T
V
E
R
G
E
I
L
L
D
G
E
N
I
L
E
------------------
L
--
S
P
D
------------
E
R
A
-------
R
K
G
L
F
L
A
F
Q
Y
P
V
E
V
P
G
V
T
I
A
N
F
L
R
L
A
L
----
Q
A
-
K
L
---------
G
R
E
-
V
-
G
V
A
-----
E
F
W
T
K
V
K
K
A
L
E
L
L
D
W
D
E
S
Y
L
-
S
R
Y
L
N
E
G
F
S
G
G
E
K
K
R
N
E
I
L
Q
L
L
V
L
-
E
P
T
Y
A
V
L
D
E
T
D
S
G
L
D
I
D
A
L
K
V
V
A
R
G
V
N
A
M
R
-
G
-
P
N
F
G
A
L
V
I
T
H
Y
Q
R
I
L
N
Y
I
Q
P
D
K
V
H
V
M
M
D
G
R
V
V
A
T
G
G
-
P
E
L
A
L
E
L
E
A
K
G
Y
E
W
L
K
E
K
V
-------------
1
PsiBlast_PDB
96.17
60%
-112
- C1 -
2D2E
3
?
A:
[2-245]
-
S
Q
L
E
I
R
D
L
W
A
S
I
D
G
-
E
T
I
L
K
G
V
N
L
V
V
P
K
G
E
V
H
A
L
M
G
P
N
G
A
G
K
S
T
L
G
K
I
L
A
G
-----
D
P
E
Y
T
V
E
R
G
E
I
L
L
D
G
E
N
I
L
E
------------------
L
--
S
P
D
------------
E
R
A
-------
R
K
G
L
F
L
A
F
Q
Y
P
V
-
V
P
G
V
T
I
A
N
F
L
R
L
A
L
----
Q
A
-
K
L
---------
G
R
E
-
V
-
G
V
A
-----
E
F
W
T
K
V
K
K
A
L
E
L
L
D
W
D
E
S
Y
L
-
S
R
Y
L
N
E
----
G
E
K
K
R
N
E
I
L
Q
L
L
V
L
-
E
P
T
Y
A
V
L
D
E
T
D
S
G
L
D
I
D
A
L
K
V
V
A
R
G
V
N
A
M
R
-
G
-
P
N
F
G
A
L
V
I
T
H
Y
Q
R
I
L
N
Y
I
Q
P
D
K
V
H
V
M
M
D
G
R
V
V
A
T
G
G
-
P
E
L
A
L
E
L
E
A
K
G
Y
E
W
L
K
E
K
--------------
4
PsiBlast_PDB
90.31
51%
-101
- C1 -
2ZU0
1
SUFC_ECOLI
C:
[21-266]
---
L
S
I
K
D
L
H
V
S
V
E
D
-
K
A
I
L
R
G
L
S
L
D
V
H
P
G
E
V
H
A
I
M
G
P
N
G
S
G
K
S
T
L
S
A
T
L
A
G
-----
R
E
D
Y
E
V
T
G
G
T
V
E
F
K
G
K
D
L
L
A
------------------
L
--
S
P
E
------------
D
R
A
-------
G
E
G
I
F
M
A
F
Q
Y
P
V
E
I
P
G
V
S
N
Q
F
F
L
Q
T
A
L
----
N
A
V
R
S
-------
Y
R
G
Q
E
T
L
-
D
R
F
-----
D
F
Q
D
L
M
E
E
K
I
A
L
L
K
M
P
E
D
L
L
-
T
R
S
V
N
V
G
F
S
G
G
E
K
K
R
N
D
I
L
Q
M
A
V
L
-
E
P
E
L
C
I
L
D
E
S
D
S
G
L
D
I
D
A
L
K
V
V
A
D
G
V
N
S
L
R
-
D
-
G
K
R
S
F
I
I
V
T
H
Y
Q
R
I
L
D
Y
I
K
P
D
Y
V
H
V
L
Y
Q
G
R
I
V
K
S
G
D
-
F
T
L
V
K
Q
L
E
E
Q
G
Y
G
W
L
T
E
Q
--------------
3
PsiBlast_PDB
87.01
51%
-101
- C1 -
2D3W
-
SUFC_ECOLI
A:
[2-244]
---
L
S
I
K
D
L
H
V
S
V
E
D
-
K
A
I
L
R
G
L
S
L
D
V
H
P
G
E
V
H
A
I
M
G
P
N
G
S
G
K
S
T
L
S
A
T
L
A
G
-----
R
E
D
Y
E
V
T
G
G
T
V
E
F
K
G
K
D
L
L
A
------------------
L
--
S
P
E
------------
D
R
A
-------
G
E
G
I
F
M
A
F
Q
Y
P
V
E
I
P
G
V
S
N
Q
F
F
L
Q
T
A
L
----
N
A
V
R
S
-------
Y
R
G
Q
E
T
L
-
D
R
F
-----
D
F
Q
D
L
M
E
E
K
I
A
L
L
K
M
P
E
D
L
L
-
T
R
S
V
N
V
G
F
S
G
G
E
K
K
R
N
D
I
L
Q
M
A
V
L
-
E
P
E
L
C
I
L
D
E
S
D
S
G
L
D
I
D
A
L
K
V
V
A
D
G
V
N
S
L
R
-
D
-
G
K
R
S
F
I
I
V
T
H
Y
Q
R
I
L
D
Y
I
K
P
D
Y
V
H
V
L
Y
Q
G
R
I
V
K
S
G
D
-
F
T
L
V
K
Q
L
E
E
Q
G
Y
G
W
L
-----------------
6
PsiBlast_PDB
66.95
27%
-94
- C1 -
4WBS
1
?
A:
[38-262]
-
S
S
L
V
V
R
N
L
K
K
R
Y
G
S
-
R
T
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
-------
L
V
P
L
D
A
G
E
I
D
L
D
G
K
S
I
S
L
------------------
L
--
P
I
H
------------
K
R
A
-------
S
L
G
L
S
Y
L
P
Q
E
A
S
V
F
R
K
L
S
V
E
E
N
I
R
A
V
L
----
E
L
-
Q
V
G------
D
D
G
K
R
-
L
-
S
K
D
-----
A
I
A
S
R
T
E
A
L
L
D
E
L
Q
I
S
H
L
R
E
-
N
P
A
L
S
--
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
-
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
I
V
K
F
L
K
-
Q
-
R
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
-
D
H
A
Y
I
I
S
D
G
S
V
L
A
A
G
A
-
P
-------------------------------
7
PsiBlast_PDB
64.00
29%
-89
- C1 -
4YMS
-
?
J:
[4-221]
-----
V
N
D
V
Y
K
N
F
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
------------------
G
--
K
V
N
I-----------
N
K
V
-------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
VKVK
K
M
-
N
K
-------
K
E
A
E
E
-
L
-
A
V
----------
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
-
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-
P
E
------------------------------
62
HHSearch
63.54
26%
-78
- C1 -
1B0U
4
HISP_SALTY
A:
[5-242]
-
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
-
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
-------
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
------------------
V
--
R
D
K
DGQLKVAD
K
N
Q
L
R
L
L
-------
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
----
I
Q
-
V
L
-------
G
L
------
S
K
H
-----
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
-
R
A
-
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
-
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
-
P
E
Q
V
F
G
--------------------------
8
PsiBlast_PDB
63.43
29%
-95
- C1 -
4YMT
-
?
J:
[4-221]
-----
V
N
D
V
Y
K
N
F
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
------------------
G
--
K
V
N
I-----------
N
K
V
-------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
VKVK
K
M
-
N
K
-------
K
E
A
E
E
-
L
-
A
V
----------
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
-
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-
P
E
------------------------------
9
PsiBlast_PDB
63.03
29%
-93
- C1 -
4YMU
2
?
J:
[4-221]
-----
V
N
D
V
Y
K
N
F
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
------------------
G
--
K
V
N
I-----------
N
K
V
-------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
VKVK
K
M
-
N
K
-------
K
E
A
E
E
-
L
-
A
V
----------
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
-
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-
P
E
------------------------------
11
PsiBlast_PDB
62.08
29%
-93
- C1 -
4YMW
-
?
J:
[4-221]
-----
V
N
D
V
Y
K
N
F
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
------------------
G
--
K
V
N
I-----------
N
K
V
-------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
VKVK
K
M
-
N
K
-------
K
E
A
E
E
-
L
-
A
V
----------
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
-
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-
P
E
------------------------------
10
PsiBlast_PDB
62.01
29%
-89
- C1 -
4YMV
1
?
J:
[4-221]
-----
V
N
D
V
Y
K
N
F
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
------------------
G
--
K
V
N
I-----------
N
K
V
-------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
VKVK
K
M
-
N
K
-------
K
E
A
E
E
-
L
-
A
V
----------
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
-
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
-
P
E
------------------------------
5
PsiBlast_PDB
61.41
28%
-84
- C1 -
1VPL
2
?
A:
[14-249]
-
G
A
V
V
V
K
D
L
R
K
R
I
G
K
-
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
-----
L
I
K
--
P
S
S
G
I
V
T
V
F
G
K
N
V
V
E
------------------
E
--
P
H
E
------------
V
R
K
L
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
Q
------
G
I
E
Y
L
R
F
V
A
G
F
Y
----
A
S
-
S
S
-------
S
E
I
E
E
-
M
--------------
V
E
R
A
T
E
I
A
G
L
G
E
K
I
K
-
D
R
V
--
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
-
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
-
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
-
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
E
E
V
-------------
48
HHSearch
60.79
22%
-89
- C1 -
1V43
-
?
A:
[10-237]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
-
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
-------
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
------------------
L
--
P
P
K
----------------------
D
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
L
-------
K
K
-------
F
P
-------
K
D
-----
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
-
E
L
L
-
N
R
-
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
-
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
-
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
-
P
T
E
V
Y
---------------------------
65
HHSearch
60.74
25%
-88
- C1 -
1G6H
3
LIVG_METJA
A:
[5-240]
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
E
-
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
-------
F
L
K
A
D
E
G
R
V
Y
F
E
N
K
D
I
T
N
------------------
K
--
E
P
A
------------
E
L
Y
-------
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
----
I
C
-
P
G
ES
P
L
N
S
L
F
Y
K
K
W
-
I
P
K
E
E
-----
E
M
V
E
K
A
F
K
I
L
E
F
L
K
L
S
H
-
L
Y
-
D
-
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
-
A
-
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
-
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
-
G
E
E
E
----------------------------
46
HHSearch
59.95
27%
-85
- C1 -
2IT1
-
?
A:
[1-221]
M
V
E
I
K
L
E
N
I
V
K
K
F
G
N
-
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
-------
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
------------------
L
--
P
P
K
----------------------
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
----
E
L
-
R
K
-------
A
P
-------
R
E
-----
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
-
L
L
-
N
-
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
-
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
-
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
-
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
-
P
D
E
V
----------------------------
37
Fugue
59.76
23%
-77
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
-
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
LEKPS-------
E
G
A
I
I
V
N
G
----
Q
NI
N
L
V
R
D
KDGQLKVAD
K
N
Q
--
L
R
L
------------
L
R
T
--------
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
----
I
Q
-
V
L
------------------GLS
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G--
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
--
Q
G
K
I
E
E
E
G
-
D
P
E
Q
V
F
G
N
P
-
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
-----
63
HHSearch
57.73
25%
-85
- C1 -
2OLJ
4
?
A:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
-------
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
------------------
K
DT
N
L
N
------------
K
-
V
-------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
-
V
R
-------
K
W
------
P
R
E
-----
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
---------------------------
61
HHSearch
57.04
25%
-82
- C1 -
1JI0
1
?
A:
[5-228]
-
I
V
L
E
V
Q
S
L
H
V
Y
Y
G
A
-
I
H
A
I
K
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
-------
L
V
R
A
Q
K
G
K
I
I
F
N
G
Q
D
I
T
N
------------------
K
--
P
A
H
------------
V
I
N
-------
R
M
G
I
A
L
V
P
E
G
R
R
I
F
P
E
L
T
V
Y
E
N
L
M
M
G
A
----
Y
N
-
R
K
-------
D
K
----
E
-
G
--------
I
K
R
D
L
E
W
I
F
S
L
F
P
R
L
K
E
R
L
-
K
-
Q
L
G
G
T
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
-
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
-
Q
-
E
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
-
K
V
A
H
Y
G
Y
V
L
E
T
G
Q
I
V
L
E
G
K
-
A
S
E
L
L
D
--------------------------
49
HHSearch
56.90
23%
-82
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-223]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
-------
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
------------------
T
--
P
P
---------------
A
-------
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
----
K
L
-
A
G
-------
A
K
-------
K
E
-----
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
-
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
-
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
-
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
-
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
-
P
L
E
L
Y
H
--------------------------