@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2446: (2016-04-03 )
MKRRTRKCSLVFILGILIFSCLSGFGTNVFAMDGEYHSPYGDDDLYTVQPTERSPRDPKAGEDVILNITTWPIENGQDVWVEWTKNGVAQENVTAAYDYNSGNNTYWKADLGKFEKGDEITYTTKGSTNGGTAYESGPFTFYVTDWEYVQDVTSVVDNGDSITLNMTATAGDFSPKLYLSFEDLDTLRMELSPTGKETGHAGKSGYTVEDTAEKVTVTTEDLSIEIQKSPYRMEVHQADGTLLTSEYTTANSLGWLTDGKNVINQYQNNFMTPSDEAFYGFGERYDTINQRGKDVETYVYNEYQDQAQTERTYLAVPFFVSANKYGMYVNSDFHSQFQMASKVEDKYSFVLDNDGDMTNMLDYYVISGKDQNDIVNNYTDITGKTTLLPKWAFGLWMSANEWDRESDVSSALSNAKANDIPATGFVLEQWSDEETYYIWNNATYTAKKNGEAFSYDDFTFNGKWTDPKGMVDSVHDAGMNIVLWQVPVLKDDGTVYEQRDNDEEYMISQGYSADDGTGAPYRVPASQWFGNGILLDFTNKDAVDWWTSQREYLLTEVGIDGFKTDGGEMVWGRDTTFSNGEKGQEMRNRYPTDYVSSYFDFAKSINPEAVSFSRSGTSGAQKSGIYWSGDQTSTFDSFQASLKAGLSASTSGVSYWAWDMAGFTGDYPTAELYKRATAMAAFAPIMQFHSEKSDPSPSEERSPWNAVARTGDETILPTFQKYLYTRMNLLPYIYTAAKDTADNGKSMMRQMAMDYPEDVNARDLDEQYMFGDDLLVAPIVQEGQTEKEVYLPEGEWVDIWNGGVHPGGETISYYADVDTLPVFAKAGAIIPMNMTDGYQLGQNVGNDLKSYDNLTFRVYPSGDSEYSFYDDVNGGEMRDISVSEDFANEKVSVDLPAMADETTMQVFSTEPTSVTIDGADVAKADTLDAFNEATTGYYYDTVQNLTYVKAAAKDAKQAIVLNGVNHAPYEAEFGHLTNVTTASDHAGYTGTGFVAGFDAEKEAVEFDIDAVDGASDYTMEVRYSAGVEDATRTVYINGKKQQITLPKTANWDTWNTVEVPVTLQAGNNQVVFDFEADDTAGINFDHVVIKK
Atome Classification :
(20 SA)
----.........10....---....20........30........40........50........60........-----70........80........90----........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.....------.-----.-200-.-----........210.......220.......230.......-.-240.........--250.....-..260.......270.......280...-....290-.........--300.....-....310.......320----..----.-----.....330.......340.-..-------------------------------------------------------------.----------------------------------------------------------------------------------------...350..------------.....360-----........370.......380.......390.......400-...--.--.....410.......420......-------.430.......440.......450.......460-........470.......480.......490...--....500.......510.....-.-.520.......530-------------------.---....----....540.......550...-------....560.---..---------------------------....-570..--------------------------------..-----------------------------------.-------.--..580.---------.---------..--------------------------------.....590.......600...--...--.--610--.......620-..-..-...630.......640.......650.......660.----------------------.-------------..-----.----------------------..670-------.........680.......690.......700.......710.--......720.......730.......740.......750..-.....760....-----...770.......780.......790..-.-....800-....-...810.......820.......830--.......840...------------....850.......860--.---.--......870-----........880..---------.....890.-----......900....-...910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MKRRTRK
C
S
L
V
F
I
L
G
---
I
L
I
F
S
C
L
S
G
FGT
N
V
F
A
MDGEYHSPYGDDD
L
Y
T
VQPTERSPRDPKAG
E
D
V
I
L
N
I
T
-----TWPIENG
Q
D
V
W
V
E
WTKNGVAQE----
N
V
T
A
A
Y
D
YNSGN
N
T
Y
W
KADLGKFEKGD
E
I
T
Y
T
TKGSTNGGTAYESG
P
F
T
F
Y
VT
D
W
E
Y
V
Q
D
V
T
S
V
VDNG
D
S
I
T
L
N
M
T
A
TAGDFS
P
K
L
Y
L
S
FED
L
D
T
L
R
MELSPTGKE------T-----G-H---A-----GKSG
Y
T
VEDTA
E
K
V
T
V
T
TE
D
L
S
I
E
I
QKS
P
Y
-
R
M
E
V
HQA-D-
G
--
T
L
L
T
S
EYTT--ANSLGWLT-D
G
K
N
V
I
N
Q
Y
Q
NNFMTPSD
E
A
F
Y
GFG
E
R
Y
-
D
T
I
NQ---RGKDVE
T
Y
V
--
Y
--
N
E
Y
Q
D
-
Q
AQTE
R
T
Y
L
A
V
P
F
F
V
S-----AN----K-----
Y
G
M
Y
VNS
D
F
H
S
Q
F
Q
M
A
S
KV-ED-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
Y
S
F
V
LDND------------GDM
T
N
M
L
------
D
Y
Y
V
ISGKDQ
N
D
I
VNNYTDITGK
T
T
LLPKWA
F
G
L
W
MSAN---EWD--R--
E
S
D
V
S
S
A
L
SNAKANDIPAT
G
F
V
L
E-------QWSDE
E
T
Y
Y
I
WNN
A
T
Y
T
AKKNGEAFSYD
D
F
T
F-N-GKWTDP
K
G
M
V
D
S
V
H
DAG
M
N
I
V
L
W
QVPVLKDDG
T
V
--YEQRDNDE
E
Y
M
ISQGYSADDGT-G-APYRV
P
A
S
Q
WFG---------------------N---
G
I
L
L
----DFTNKD
A
V
D
W
W
TSQ
R
E
Y
L
L
T
-------EVGIDGFK---TD---------------------------GG
E
M
-
V
W-GR--------------------------------DT-----------------------------------T-------F--SNG--E---------
K
---------
G
Q
--------------------------------
E
M
R
N
RY
P
T
D
Y
V
S
S
Y
F
D
F
A
K
SI--NPE--
A
--
V
S
F--SRSGTSGAQK-S
G
-
I
Y
-WSGDQTS
T
F
D
S
F
Q
A
S
L
K
AGLSASTSG
V
S
Y
W
A
W
DMAGF----------------------T-------------GD-----Y----------------------
P
T
A
---------
E
L
Y
K
R
A
T
A
M
A
A
F
A
P
I
M
Q
F
HSEKSDPSPSEERS
P
W
N
A
V
ARTGDE--
T
I
L
P
T
F
Q
K
Y
L
Y
T
R
M
N
L
L
P
Y
IYTAAKDTAD
N
G
K
S
M
M
R
Q
M
A
MD-YPEDVNA
R
D
L
D
E
-----QYMFGDD
L
L
V
A
P
I
VQEGQTE
K
E
V
YLPEG-
E
-
W
V
D
IWNG-GVHP-GG
E
T
I
S
Y
Y
ADVDTLPVFAKAG
A
I
I
P
M--NMTD
G
Y
Q
L
G
Q
N
V
G
------------
N
D
L
K
SYD
N
L
T
F
R
V
YPS---G---D--SE
Y
S
F
YDD------VNGG
E
M
R
D
I
S
VSE---------DFANE
K
V
S
V-----DLPAMADE
T
T
M
Q
V
-FSTEP
T
S
V
T
IDGADVAKAD
T
L
D
A
FNEATT
G
Y
Y
Y
D
T
V
Q
N
L
T
Y
V
K
A
A
AKDA
K
Q
A
I
V
L
NGVNHAPYEAEFGHLTNVTTASDHAGYTGT
G
F
V
AGFDAEK
E
A
V
E
F
D
I
D
AVDGAS
D
Y
T
M
E
V
R
Y
SAGVEDA
T
R
T
V
Y
INGK
K
Q
Q
I
TLPKTANWDTW
N
T
V
E
V
P
V
T
L
QAGN
N
Q
V
V
F
D
FEADDTAGINF
D
H
V
V
IKK
2
PsiBlast_PDB
85.61
97%
-57
- C1 -
4KWU
13
?
A:
[26-1084]
---------------------------------------
D
G
E
Y
H
S
P
Y
G
D
D
D
L
Y
T
V
Q
P
T
E
R
S
P
R
D
P
K
A
G
E
D
V
I
L
N
I
T
-----
T
W
P
I
E
N
G
Q
D
V
W
V
E
W
T
K
N
G
V
A
Q
E
----
N
V
T
A
A
Y
D
Y
N
S
G
N
N
T
Y
W
K
A
D
L
G
K
F
E
K
G
D
E
I
T
Y
T
T
K
G
S
T
N
G
G
T
A
Y
E
S
G
P
F
T
F
Y
V
T
D
W
E
Y
V
Q
D
V
T
S
V
V
D
N
G
D
S
I
T
L
N
M
T
A
T
A
G
D
F
S
P
K
L
Y
L
S
F
E
D
L
D
T
L
R
M
E
L
S
P
T
G
K
E
------
T
-----
G
-
H
---
A
-----
G
K
S
G
Y
T
V
E
D
T
A
E
K
V
T
V
T
T
E
D
L
S
I
E
I
Q
K
S
P
Y
-
R
M
E
V
H
Q
A
-
D
-
G
--
T
L
L
T
S
E
Y
T
T
--
A
N
S
L
G
W
L
T
-
D
G
K
N
V
I
N
Q
Y
Q
N
N
F
M
T
P
S
D
E
A
F
Y
G
F
G
E
R
Y
-
D
T
I
N
Q
---
R
G
K
D
V
E
T
Y
V
--
Y
--
N
E
Y
Q
D
-
Q
A
Q
T
E
R
T
Y
L
A
V
P
F
F
V
S
-----
A
N
----
K
-----
Y
G
M
Y
V
N
S
D
F
H
S
Q
F
Q
M
A
S
K
V
-
E
D
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
Y
S
F
V
L
D
N
D
------------
G
D
M
T
N
M
L
------
D
Y
Y
V
I
S
G
K
D
Q
N
D
I
V
N
N
Y
T
D
I
T
G
K
T
T
L
L
P
K
W
A
F
G
L
W
M
S
A
N
---
E
W
D
--
R
--
E
S
D
V
S
S
A
L
S
N
A
K
A
N
D
I
P
A
T
G
F
V
L
E
-------
Q
W
S
D
E
E
T
Y
Y
I
W
N
N
A
T
Y
T
A
K
K
N
G
E
A
F
S
Y
D
D
F
T
F
-
N
-
G
K
W
T
D
P
K
G
M
V
D
S
V
H
D
A
G
M
N
I
V
L
W
Q
V
P
V
L
K
D
D
G
T
V
--
Y
E
Q
R
D
N
D
E
E
Y
M
I
S
Q
G
Y
S
A
D
D
G
T
-
G
-
A
P
Y
R
V
P
A
S
Q
W
F
G
---------------------
N
---
G
I
L
L
----
D
F
T
N
K
D
A
V
D
W
W
T
S
Q
R
E
Y
L
L
T
-------
E
V
G
I
D
G
F
K
---
T
D
---------------------------
G
G
E
M
-
V
W
-
G
R
--------------------------------
D
T
-----------------------------------
T
-------
F
--
S
N
G
--
E
---------
K
---------
G
Q
--------------------------------
E
M
R
N
R
Y
P
T
D
Y
V
S
S
Y
F
D
F
A
K
S
I
--
N
P
E
--
A
--
V
S
F
--
S
R
S
G
T
S
G
A
Q
K
-
S
G
-
I
Y
-
W
S
G
D
Q
T
S
T
F
D
S
F
Q
A
S
L
K
A
G
L
S
A
S
T
S
G
V
S
Y
W
A
W
D
M
A
G
F
----------------------
T
-------------
G
D
-----
Y
----------------------
P
T
A
---------
E
L
Y
K
R
A
T
A
M
A
A
F
A
P
I
M
Q
F
H
S
E
K
S
D
P
S
P
S
E
E
R
S
P
W
N
A
V
A
R
T
G
D
E
--
T
I
L
P
T
F
Q
K
Y
L
Y
T
R
M
N
L
L
P
Y
I
Y
T
A
A
K
D
T
A
D
N
G
K
S
M
M
R
Q
M
A
M
D
-
Y
P
E
D
V
N
A
R
D
L
D
E
-----
Q
Y
M
F
G
D
D
L
L
V
A
P
I
V
Q
E
G
Q
T
E
K
E
V
Y
L
P
E
G
-
E
-
W
V
D
I
W
N
G
-
G
V
H
P
-
G
G
E
T
I
S
Y
Y
A
D
V
D
T
L
P
V
F
A
K
A
G
A
I
I
P
M
--
N
M
T
D
G
Y
Q
L
G
Q
N
V
G
------------
N
D
L
K
S
Y
D
N
L
T
F
R
V
Y
P
S
---
G
---
D
--
S
E
Y
S
F
Y
D
D
------
V
N
G
G
E
M
R
D
I
S
V
S
E
---------
D
F
A
N
E
K
V
S
V
-----
D
L
P
A
M
A
D
E
T
T
M
Q
V
-
F
S
T
E
P
T
S
V
T
I
D
G
A
D
V
A
K
A
D
T
L
D
A
F
N
E
A
T
T
G
Y
Y
Y
D
T
V
Q
N
L
T
Y
V
K
A
A
A
K
D
A
K
Q
A
I
V
L
N
G
V
N
H
A
P
Y
E
A
E
F
G
H
L
T
N
V
T
T
A
S
D
H
A
G
Y
T
G
T
G
F
V
A
G
F
D
A
E
K
E
A
V
E
F
D
I
D
A
V
D
G
A
S
D
Y
T
M
E
V
R
Y
S
A
G
V
E
D
A
T
R
T
V
Y
I
N
G
K
K
Q
Q
I
T
L
P
K
T
A
N
W
D
T
W
N
T
V
E
V
P
V
T
L
Q
A
G
N
N
Q
V
V
F
D
F
E
A
D
D
T
A
G
I
N
F
D
H
V
V
I
K
K
1
PsiBlast_PDB
85.21
97%
-57
* C1 *
4KMQ
5
?
A:
[26-1084]
---------------------------------------
D
G
E
Y
H
S
P
Y
G
D
D
D
L
Y
T
V
Q
P
T
E
R
S
P
R
D
P
K
A
G
E
D
V
I
L
N
I
T
-----
T
W
P
I
E
N
G
Q
D
V
W
V
E
W
T
K
N
G
V
A
Q
E
----
N
V
T
A
A
Y
D
Y
N
S
G
N
N
T
Y
W
K
A
D
L
G
K
F
E
K
G
D
E
I
T
Y
T
T
K
G
S
T
N
G
G
T
A
Y
E
S
G
P
F
T
F
Y
V
T
D
W
E
Y
V
Q
D
V
T
S
V
V
D
N
G
D
S
I
T
L
N
M
T
A
T
A
G
D
F
S
P
K
L
Y
L
S
F
E
D
L
D
T
L
R
M
E
L
S
P
T
G
K
E
------
T
-----
G
-
H
---
A
-----
G
K
S
G
Y
T
V
E
D
T
A
E
K
V
T
V
T
T
E
D
L
S
I
E
I
Q
K
S
P
Y
-
R
M
E
V
H
Q
A
-
D
-
G
--
T
L
L
T
S
E
Y
T
T
--
A
N
S
L
G
W
L
T
-
D
G
K
N
V
I
N
Q
Y
Q
N
N
F
M
T
P
S
D
E
A
F
Y
G
F
G
E
R
Y
-
D
T
I
N
Q
---
R
G
K
D
V
E
T
Y
V
--
Y
--
N
E
Y
Q
D
-
Q
A
Q
T
E
R
T
Y
L
A
V
P
F
F
V
S
-----
A
N
----
K
-----
Y
G
M
Y
V
N
S
D
F
H
S
Q
F
Q
M
A
S
K
V
-
E
D
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
Y
S
F
V
L
D
N
D
------------
G
D
M
T
N
M
L
------
D
Y
Y
V
I
S
G
K
D
Q
N
D
I
V
N
N
Y
T
D
I
T
G
K
T
T
L
L
P
K
W
A
F
G
L
W
M
S
A
N
---
E
W
D
--
R
--
E
S
D
V
S
S
A
L
S
N
A
K
A
N
D
I
P
A
T
G
F
V
L
E
-------
Q
W
S
D
E
E
T
Y
Y
I
W
N
N
A
T
Y
T
A
K
K
N
G
E
A
F
S
Y
D
D
F
T
F
-
N
-
G
K
W
T
D
P
K
G
M
V
D
S
V
H
D
A
G
M
N
I
V
L
W
Q
V
P
V
L
K
D
D
G
T
V
--
Y
E
Q
R
D
N
D
E
E
Y
M
I
S
Q
G
Y
S
A
D
D
G
T
-
G
-
A
P
Y
R
V
P
A
S
Q
W
F
G
---------------------
N
---
G
I
L
L
----
D
F
T
N
K
D
A
V
D
W
W
T
S
Q
R
E
Y
L
L
T
-------
E
V
G
I
D
G
F
K
---
T
D
---------------------------
G
G
E
M
-
V
W
-
G
R
--------------------------------
D
T
-----------------------------------
T
-------
F
--
S
N
G
--
E
---------
K
---------
G
Q
--------------------------------
E
M
R
N
R
Y
P
T
D
Y
V
S
S
Y
F
D
F
A
K
S
I
--
N
P
E
--
A
--
V
S
F
--
S
R
S
G
T
S
G
A
Q
K
-
S
G
-
I
Y
-
W
S
G
D
Q
T
S
T
F
D
S
F
Q
A
S
L
K
A
G
L
S
A
S
T
S
G
V
S
Y
W
A
W
D
M
A
G
F
----------------------
T
-------------
G
D
-----
Y
----------------------
P
T
A
---------
E
L
Y
K
R
A
T
A
M
A
A
F
A
P
I
M
Q
F
H
S
E
K
S
D
P
S
P
S
E
E
R
S
P
W
N
A
V
A
R
T
G
D
E
--
T
I
L
P
T
F
Q
K
Y
L
Y
T
R
M
N
L
L
P
Y
I
Y
T
A
A
K
D
T
A
D
N
G
K
S
M
M
R
Q
M
A
M
D
-
Y
P
E
D
V
N
A
R
D
L
D
E
-----
Q
Y
M
F
G
D
D
L
L
V
A
P
I
V
Q
E
G
Q
T
E
K
E
V
Y
L
P
E
G
-
E
-
W
V
D
I
W
N
G
-
G
V
H
P
-
G
G
E
T
I
S
Y
Y
A
D
V
D
T
L
P
V
F
A
K
A
G
A
I
I
P
M
--
N
M
T
D
G
Y
Q
L
G
Q
N
V
G
------------
N
D
L
K
S
Y
D
N
L
T
F
R
V
Y
P
S
---
G
---
D
--
S
E
Y
S
F
Y
D
D
------
V
N
G
G
E
M
R
D
I
S
V
S
E
---------
D
F
A
N
E
K
V
S
V
-----
D
L
P
A
M
A
D
E
T
T
M
Q
V
-
F
S
T
E
P
T
S
V
T
I
D
G
A
D
V
A
K
A
D
T
L
D
A
F
N
E
A
T
T
G
Y
Y
Y
D
T
V
Q
N
L
T
Y
V
K
A
A
A
K
D
A
K
Q
A
I
V
L
N
G
V
N
H
A
P
Y
E
A
E
F
G
H
L
T
N
V
T
T
A
S
-
H
A
G
Y
T
G
T
G
F
V
A
G
F
D
A
E
K
E
A
V
E
F
D
I
D
A
V
D
G
A
S
D
Y
T
M
E
V
R
Y
S
A
G
V
E
D
A
T
R
T
V
Y
I
N
G
K
K
Q
Q
I
T
L
P
K
T
A
N
W
D
T
W
N
T
V
E
V
P
V
T
L
Q
A
G
N
N
Q
V
V
F
D
F
E
A
D
D
T
A
G
I
N
F
D
H
V
V
I
K
K
43
HHSearch
60.60
26%
-43
- C1 -
2F2H
2
XYLS_ECOLI
A:
[51-711]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
F
T
L
R
F
F
S
P
Q
E
G
I
V
G
V
R
I
E
H
F
Q
G
A
------
L
NNGPH
Y
-
P
---
L
NIL--
Q
D
V
K
V
T
I
E
N
T
E
R
Y
A
E
F
K
S
G
N
L
S
A
R
V
S
K
G
E
F
W
S
L
D
F
L
-
R
-
N
-
G
--
E
R
I
T
G
S
Q
V
----
K
N
N
G
Y
V
Q
-
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
V
R
---
N
G
Q
T
V
E
T
W
N
--
R
--
D
G
G
----
T
S
T
E
Q
A
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
-
V
S
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
Q
F
S
V
E
-----------------
S
E
Y
L
------
E
Y
F
V
I
D
G
P
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
---
F
T
T
NY
D
--
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
--------------------
F
D
C
F
W
M
K
A
-----
F
Q
W
C
D
F
E
W
D
P
-
L
T
F
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
Y
I
G
Q
K
S
-----
P
----
V
F
K
E
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
-
S
L
W
Q
W
D
--
K
W
Q
P
---------------------
G
---
L
A
I
Y
----
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
L
V
A
--------
M
G
V
D
C
F
K
---
T
D
---------------------------
F
G
E
R
-
I
P
--
T
--------------------------------
D
V
-----------------------------------
Q
-------
W
--
F
D
G
--
S
---------
D
---------
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
V
L
K
D
T
VG
E
E
E
--
A
--
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
-
F
P
-
V
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
----------------------
E
-------------
N
T
----------------------------
A
P
A
---------
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
K
S
------
Y
R
V
P
W
A
Y
D
D
E
-------
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
-
F
P
D
D
P
A
C
D
Y
L
D
R
-----
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
-
W
T
H
L
W
H
N
-
D
E
L
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
--
G
N
N
D
Q
R
-------------------
P
D
Y
V
W
H
E
G
T
A
F
H
L
F
N
L
---
Q
DG
H
E
--
A
V
C
E
V
P
A
A
------
D
G
--
S
V
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
59.89
24%
-36
- C1 -
2XVL
12
?
A:
[45-945]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
A
Q
V
E
R
T
A
E
G
V
V
L
T
L
P
E
G
---
T
V
K
K
L
R
L
Q
V
M
G
E
R
I
I
R
V
T
A
L
P
G
T
D
F
------
G
I----
V
P
E
SIQ
V
VAKPA
T
N
V
P
F
S
V
D
Q
A
G
E
K
L
V
L
K
T
S
Q
V
S
A
E
V
S
L
L
D
G
-
T
V
S
F
R
D
A
-
K
-
G
--
N
V
L
L
Q
E
E
N
R
G
T
F
S
P
V
I
H
D
P
D
P
V
D
A
D
S
Y
A
L
R
Q
E
F
N
R
G
S
D
E
G
F
F
G
L
G
Q
H
Q
N
G
Q
V
N
Y
---
A
G
E
N
V
E
L
T
T
--
Y
-------------
N
L
V
I
S
I
P
F
L
V
S
-----
S
R
----
N
-----
Y
G
L
L
W
D
N
N
S
I
T
R
F
G
D
P
R
E
A
-
Q
P
LNQS
L
K
L
Y
D
AEGKEG
G
L
T
V
R
Y
F
VGDELK
L
T
R
V
E
ADFNHQFYKQGNELENPFPEEV
A
G
A
Y
K
N
N
T
L
R
I
E
L
E
G
S
I
E
A
QAT
G
K
H
Q
F
K
M
Y
N
S
G
Y
A
Q
L
S
L
DGEVV
L
D
R
W
R
MNW
N
P
W
Y
H
N
F
Y
R
E
L
N
AG
D
K
H
K
L
K
V
S
W
KPDG
G
F
F
H
L
R
H
L
D
P
LPANEQ
H
E
L
S
L
--
A
------------
S
E
T
G
K
A
I
------
D
Y
Y
F
V
A
G
D
T
K
D
D
I
I
S
G
Y
R
Q
L
T
G
K
S
V
M
L
P
K
W
A
Y
G
F
W
Q
S
R
E
---
R
Y
K
--
S
--
S
D
E
I
I
Q
N
L
K
E
Y
R
D
R
K
I
P
I
D
N
I
V
--------------------
L
D
W
S
Y
W
P
E
D
-----
A
W
G
S
H
D
F
D
K
-
Q
F
F
P
D
P
K
A
L
V
D
K
V
H
A
M
N
A
Q
I
M
I
S
V
W
P
K
F
Y
P
T
T
D
---------
N
Y
K
E
L
N
A
K
G
F
M
F
N
R
N
L
-
D
-
E
K
----
N
L
D
W
I
G
---------------------
K
G
Y
L
N
A
F
Y
----
D
P
F
S
P
E
A
T
A
I
F
W
K
Q
I
R
D
K
I
N
-------
V
H
G
F
D
A
W
W
---
L
D
---------------------------
A
V
E
P
-
D
I
-
H
S
--------------------------------
N
L
-----------------------------------
T
F
E
K
R
K
W
L
M
TP
N
A
R
--
G
---------
N
---------
G
A
--------------------------------
E
I
F
N
A
Y
A
V
P
H
A
E
G
V
Y
Q
G
E
L
A
T
DG
D
K
R
--
S
--
F
I
L
--
T
R
S
G
F
G
G
I
Q
R
-
T
G
S
A
I
-
W
S
G
D
I
V
S
R
W
S
D
M
K
D
Q
I
A
A
G
I
G
T
N
L
A
G
V
T
N
W
T
F
D
I
G
G
F
----------------------
T
-------------
P
E
-----
D
RFRHGKKGFVGSWTALDAEQ
V
D
E
W
Q
---------
E
L
N
T
R
W
Y
Q
F
G
A
F
V
P
L
Y
R
S
H
G
Q
N
------
P
Y
R
E
I
F
N
I
A
D
E
G
--
T
--
E
V
Y
N
A
M
V
W
Y
T
K
L
R
Y
Y
L
M
P
Y
I
Y
T
L
G
G
D
T
Y
H
K
D
G
T
I
M
R
G
L
V
M
D
-
F
P
N
D
R
K
A
W
D
I
N
T
-----
Q
Y
M
F
G
P
A
F
L
V
N
P
V
Y
E
Y
K
A
R
S
R
D
V
Y
L
P
A
G
S
D
-
W
Y
N
F
Y
T
G
-
E
K
L
A
-
G
G
Q
T
I
T
A
D
A
P
L
A
R
V
P
L
F
V
K
A
G
A
I
V
P
T
--
G
P
L
I
Q
H
-------------------
V
D
E
G
L
N
S
P
L
L
I
T
V
Y
T
G
---
A
---
N
--
G
S
F
D
I
Y
E
D
------
D
G
--
R
S
L
K
Y
Q
Q
G
E
W
S
R
I
P
L
S
Y
-
D
D
V
T
G
T
L
I
I
-----
G
D
R
V
G
S
F
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
59.84
21%
-38
- C1 -
4BA0
12
OL4AG_CELJU
A:
[35-817]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
F
Y
K
E
H
K
L
R
N
D
G
L
V
I
T
T
N
------
Q
G
N
I
R
L
Q
F
K
S
E
A
A
I
E
V
L
Y
R
A
D
S
K
Q
LPSFAL
A
-----
Q
-
P
---
E
-----
S
A
I
K
A
Q
L
T
E
T
E
N
H
L
Q
F
S
G
G
T
L
T
A
R
I
Q
K
R
P
F
-
A
I
S
Y
Y
R
D
-
S
-
E
--
L
L
L
A
E
E
S
G
F
--
Q
V
-------------
N
K
I
N
F
R
F
Y
L
S
P
G
E
K
I
L
G
G
G
Q
R
I
-
L
G
M
D
R
---
R
G
Q
R
F
P
L
Y
N
--
R
--
A
H
Y
G
Y
-
S
D
H
S
G
Q
M
Y
F
G
L
P
A
I
M
S
-----
S
K
----
Q
-----
Y
I
L
V
F
D
N
S
A
S
G
A
M
D
I
G
K
T
E
-
S
D
-------------------------------------------------------------
I
----------------------------------------------------------------------------------------
L
Q
L
E
A
K
S
G
------------
R
-----
S
------
A
Y
I
L
V
A
G
N
S
Y
P
S
L
I
E
N
F
T
Q
V
T
G
R
Q
P
L
P
P
R
W
A
L
G
S
F
A
S
R
F
---
G
Y
R
--
S
--
E
A
E
T
R
A
T
V
Q
K
Y
K
T
E
D
F
P
L
D
T
I
V
L
--------------------
D
L
Y
W
F
G
K
D
I
K
G
--
H
M
G
N
L
D
W
-
D
K
E
N
F
P
T
P
L
D
M
M
A
D
F
K
Q
Q
G
V
K
T
V
L
I
T
E
P
F
V
L
T
S
S
K
R
--
W
D
D
A
V
K
A
-------
K
A
L
A
K
D
P
Q
-
G
-
Q
P
K
A
F
E
L
--
Y
F
G
---------------------
N
---
G
G
I
I
----
D
V
F
S
K
E
G
S
R
W
F
S
S
I
Y
K
D
L
S
K
-------
Q
-
G
V
A
G
W
W
---
G
D
---------------------------
L
G
E
P
-
E
M
-
H
P
--------------------------------
E
D
-----------------------------------
T
-------
Q
--
H
A
I
--
G
---------
D
---------
A
D
--------------------------------
T
V
H
N
A
Y
G
H
R
W
A
E
M
L
Y
Q
Q
Q
L
D
Q
--
F
P
E
L
R
P
--
F
I
M
--
M
R
A
G
F
V
G
S
Q
R
-
Y
G
-
M
I
P
W
T
G
D
V
S
R
T
W
G
G
L
A
S
Q
V
E
L
A
L
Q
M
S
L
L
G
F
G
Y
I
H
S
D
L
G
G
F
----------------------
A
-------------
D
G
-----
E
T---------------------
L
D
K
---------
E
M
Y
I
R
W
L
Q
Y
G
V
F
Q
P
V
Y
R
P
H
G
--
Q
D
H
I
P
S
E
---
P
V
F
Q
-----
D
E
--
E
T
K
A
I
L
R
P
L
V
K
L
R
Y
R
M
L
P
Y
I
Y
T
A
A
Y
Q
N
T
L
T
G
M
P
L
M
R
P
L
F
F
S
-
D
E
K
N
P
A
L
I
D
N
K
T
-----
S
Y
F
W
G
D
S
L
L
V
T
P
I
T
Q
A
G
V
E
S
V
S
I
P
A
P
K
G
-
V
-
W
F
D
F
W
K
D
-
T
R
Y
Q
T
D
G
A
P
L
T
L
P
T
D
L
H
T
I
P
V
L
V
K
A
G
A
F
M
P
Y
--
V
P
A
V
S
T
-------------------
T
E
D
Y
R
S
D
S
L
E
I
H
Y
Y
A
D
ASV
P
---
L
--
A
Q
G
E
I
F
E
D
------------------------------------------------------------------
D
G
K
D
---------
P
N
S
I
K
R
N
Q
F
D
L
L
T
L
Q
A
T
H
T
D
-------------------------
N
Q
L
H
F
Q
L
A
R
T
G
K
G
Y
R
G
M
----------------------
P
E
R
R
A
T
T
L
V
I
H
-
N
A
S
D
Q
Y
Q
H
L
D
I
N
G
K
T
I
A
I
A
Q
A
D
C
A
S
------
T
P
A
L
A
C
Y
D
Q
E
R
R
Q
L
Q
L
V
F
T
W
G
R
E
A
----
L
N
L
R
L
H
K
66
Fugue
59.21
24%
-33
- C1 -
1XSJ
4
XYLS_ECOLI
A:
[1-773]
----
M
K
-------------------------
I
S
D
G
N
W
---------------------------------------------------------
L
I
Q
P
G
L
N
L
I
----
H
P
L
Q
V
F
E
V
E
Q
Q
D
N
--------------
E
M
V
V
Y
A
A
P
R
D
V
R
E
R
T
W
Q
L
D
T
---------------------
P
L
F
T
L
R
F
F
S
P
Q
E
G
-----
I
V
G
V
R
I
E
H
F
Q
G
A
L
N
N
G
P
H
Y
P
------
L
-----
N
-
I
---
L
-----
Q
D
V
K
V
T
I
E
N
T
E
R
Y
A
E
F
K
S
G
N
L
S
A
R
V
S
K
G
E
F
-
W
S
L
D
F
L
R
-
N
-
G
--
E
R
I
T
G
--
S
Q
--
V
K
N
N
G
Y
V
Q
-
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
V
R
---
N
G
Q
T
V
E
T
W
N
--
R
--
D
G
G
T
S
----
T
E
Q
A
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
-
V
S
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
Q
F
S
V
E
S
-----------------
E
Y
L
------
E
Y
F
V
I
D
G
P
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
---
F
T
T
--
N
YD
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
--------------------
C
F
W
M
K
A
F
Q
W
C
D
F
E
W
D
-----
P
-
L
T
F
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
Y
I
G
Q
K
S
P
V
--
F
K
E
L
Q
E
K
-------
G
Y
L
L
K
R
P
D
-
G
-
S
L
W
Q
--
W
D
K
W
Q
P
---------------------
G
---
L
A
I
Y
----
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
L
V
A
-------
M
-
G
V
D
C
F
K
---
T
D
---------------------------
F
G
E
R
-
I
--
P
T
--------------------------------
D
V
-----------------------------------
Q
-------
W
--
F
D
G
--
S
---------
D
---------
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
V
L
K
D
T
--
V
G
E
--
E
EA
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
-
F
P
-
V
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
----------------------
E
-------------
N
T
----------------------------
A
P
A
---------
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
K
S
Y
------
R
V
P
W
A
Y
-----
D
D
--
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
-
F
P
D
D
P
A
C
D
Y
L
D
R
-----
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
-
W
T
H
L
W
H
N
-
D
E
L
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
--
G
N
N
D
Q
R
-------------------
P
D
Y
V
W
H
E
G
T
A
F
H
L
F
N
L
---
Q
---
D
--
G
H
E
A
V
C
E
V
------
P
A
A
D
G
S
V
I
F
T
L
K
A
---------
A
R
T
G
N
T
I
T
V
-----
T
G
A
G
E
A
K
N
W
T
L
C
L
-
R
N
V
V
K
-------------------------------------------------------------
V
N
G
L
Q
D
G
S
Q
A
E
S
E
Q
G
--------------------------------------------
L
V
V
K
P
Q
G
N
A
L
T
I
T
L
H
---------------------------------------------
3
PsiBlast_PDB
57.49
27%
-43
- C1 -
2F2H
2
XYLS_ECOLI
A:
[93-675]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
N
T
E
R
Y
A
E
F
K
S
G
N
L
S
A
R
V
S
K
G
E
F
-
W
S
L
D
F
L
R
-
N
-
G
--
E
R
I
T
G
S
Q
V
K
--
N
N
--
G
Y
V
Q
-
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
V
R
---
N
G
Q
T
V
E
T
W
-------
N
R
D
G
-
G
T
S
T
E
Q
A
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
-
V
S
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
Q
F
S
V
E
S
E
-----------------
Y
L
------
E
Y
F
V
I
D
G
P
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
W
C
D
--------------------
F
E
W
D
P
L
T
F
------
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
Y
I
G
Q
K
S
P
V
--
F
K
E
-------
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
-
S
L
W
Q
--
W
D
K
W
Q
P
---------------------
G
---
L
A
I
Y
----
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
L
V
A
--------
M
G
V
D
C
F
K
---
T
D
---------------------------
F
G
E
R
-
I
--
P
T
--------------------------------
D
V
-----------------------------------
Q
-------
W
--
F
D
G
--
S
---------
D
---------
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
V
L
K
D
T
VG
E
E
E
--
A
--
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
-
F
P
-
V
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
----------------------
E
-------------
N
T
-----
A
----------------------
P
-
A
---------
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
K
S
------
Y
R
V
P
W
---
A
Y
D
D
E
S
--
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
--
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
-
F
P
D
D
P
A
C
D
Y
L
D
R
-----
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
-
W
T
H
L
W
H
N
-
D
E
L
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
--
G
N
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
56.73
26%
-43
- C1 -
1WE5
1
XYLS_ECOLI
A:
[93-675]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
N
T
E
R
Y
A
E
F
K
S
G
N
L
S
A
R
V
S
K
G
E
F
-
W
S
L
D
F
L
R
-
N
-
G
--
E
R
I
T
G
S
Q
V
K
--
N
N
--
G
Y
V
Q
-
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
V
R
---
N
G
Q
T
V
E
T
W
-------
N
R
D
G
-
G
T
S
T
E
Q
A
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
-
V
S
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
Q
F
S
V
E
S
E
-----------------
Y
L
------
E
Y
F
V
I
D
G
P
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
W
C
D
--------------------
F
E
W
D
P
L
T
F
------
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
Y
I
G
Q
K
S
P
V
--
F
K
E
-------
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
-
S
L
W
Q
--
W
D
K
W
Q
P
---------------------
G
---
L
A
I
Y
----
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
L
V
A
-------
M
-
G
V
D
C
F
K
---
T
D
---------------------------
F
G
E
R
-
I
--
P
T
--------------------------------
D
V
-----------------------------------
Q
-------
W
--
F
D
G
--
S
---------
D
---------
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
V
L
K
D
T
VG
E
E
E
--
A
--
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
-
F
P
-
V
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
----------------------
E
-------------
N
T
-----
A
----------------------
P
-
A
---------
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
K
S
------
Y
R
V
P
W
-----
A
Y
D
D
--
E
S
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
-
F
P
D
D
P
A
C
D
Y
L
D
R
-----
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
-
W
T
H
L
W
H
N
-
D
E
L
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
--
G
N
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
56.38
27%
-42
- C1 -
1XSI
3
XYLS_ECOLI
A:
[93-675]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
N
T
E
R
Y
A
E
F
K
S
G
N
L
S
A
R
V
S
K
G
E
F
-
W
S
L
D
F
L
R
-
N
-
G
--
E
R
I
T
G
S
Q
V
K
--
N
N
--
G
Y
V
Q
-
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
V
R
---
N
G
Q
T
V
E
T
W
-------
N
R
D
G
-
G
T
S
T
E
Q
A
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
-
V
S
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
Q
F
S
V
E
S
E
-----------------
Y
L
------
E
Y
F
V
I
D
G
P
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
W
C
D
--------------------
F
E
W
D
P
L
T
F
------
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
Y
I
G
Q
K
S
P
V
--
F
K
E
-------
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
-
S
L
W
Q
--
W
D
K
W
Q
P
---------------------
G
---
L
A
I
Y
----
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
L
V
A
--------
M
G
V
D
C
F
K
---
T
D
---------------------------
F
G
E
R
-
I
--
P
T
--------------------------------
D
V
-----------------------------------
Q
-------
W
--
F
D
G
--
S
---------
D
---------
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
V
L
K
D
T
VG
E
E
E
--
A
--
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
-
F
P
-
V
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
----------------------
E
-------------
N
T
-----
A
----------------------
P
-
A
---------
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
K
S
------
Y
R
V
P
W
---
A
Y
D
D
E
S
--
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
--
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
-
F
P
D
D
P
A
C
D
Y
L
D
R
-----
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
-
W
T
H
L
W
H
N
-
D
E
L
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
--
G
N
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.07
27%
-44
- C1 -
1XSK
3
XYLS_ECOLI
A:
[93-675]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
N
T
E
R
Y
A
E
F
K
S
G
N
L
S
A
R
V
S
K
G
E
F
-
W
S
L
D
F
L
R
-
N
-
G
--
E
R
I
T
G
S
Q
V
K
--
N
N
--
G
Y
V
Q
-
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
V
R
---
N
G
Q
T
V
E
T
W
-------
N
R
D
G
-
G
T
S
T
E
Q
A
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
-
V
S
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
Q
F
S
V
E
S
E
-----------------
Y
L
------
E
Y
F
V
I
D
G
P
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
W
C
D
--------------------
F
E
W
D
P
L
T
F
------
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
Y
I
G
Q
K
S
P
V
--
F
K
E
-------
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
-
S
L
W
Q
--
W
D
K
W
Q
P
---------------------
G
---
L
A
I
Y
----
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
L
V
A
--------
M
G
V
D
C
F
K
---
T
D
---------------------------
F
G
E
R
-
I
--
P
T
--------------------------------
D
V
-----------------------------------
Q
-------
W
--
F
D
G
--
S
---------
D
---------
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
V
L
K
D
T
VG
E
E
E
--
A
--
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
-
F
P
-
V
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
----------------------
E
-------------
N
T
-----
A
----------------------
P
-
A
---------
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
K
S
------
Y
R
V
P
W
---
A
Y
D
D
E
S
--
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
--
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
-
F
P
D
D
P
A
C
D
Y
L
D
R
-----
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
-
W
T
H
L
W
H
N
-
D
E
L
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
--
G
N
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.82
26%
-47
- C1 -
2XVL
11
?
A:
[403-962]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
D
Y
Y
F
V
A
G
D
T
K
D
D
I
I
S
G
Y
R
Q
L
T
G
K
S
V
M
L
P
K
W
A
Y
G
F
W
Q
S
R
E
---
R
Y
K
--
S
--
S
D
E
I
I
Q
N
L
K
E
Y
R
D
R
K
I
P
I
D
N
I
V
L
D
--------
W
S
------
Y
W
P
E
D
A
W
G
S
H
D
F
D
K
Q
F
------------
F
P
D
P
K
A
L
V
D
K
V
H
A
M
N
A
Q
I
M
I
S
V
W
P
K
F
Y
P
T
T
D
N
--
Y
K
E
L
-
N
A
K
G
F
M
F
N
R
N
L
D
E
K
N
------------
L
D
W
I
G
---------------------
K
---
G
Y
L
N
A
F
Y
D
P
F
S
P
E
A
T
A
I
F
W
K
Q
I
R
D
K
I
N
V
-------
H
-
G
F
D
A
W
W
---
L
D
---------------------------
A
V
E
P
-
D
I
-
H
S
--------------------------------
N
L
-----------------------------------
T
-------
F
--
E
K
R
--
K
W
L
M
TPNARG
N
---------
G
A
--------------------------------
E
I
F
N
A
Y
A
V
P
H
A
E
G
V
Y
Q
G
E
L
A
T
--
D
G
D
--
K
--
R
S
F
I
L
T
R
S
G
F
G
G
I
Q
R
-
T
G
S
A
I
-
W
S
G
D
I
V
S
R
W
S
D
M
K
D
Q
I
A
A
G
I
G
T
N
L
A
G
V
T
N
W
T
F
D
I
G
G
F
----------------------
T
PEDRFRHGKKGFV
G
S
-----
W
----------------------
T
A
L
DAEQ
V
D
E
W
Q
E
L
N
T
R
W
Y
Q
F
G
A
F
V
P
L
Y
R
S
H
G
Q
----------
N
P
Y
R
E
I
F
N
I
A
D
E
GT
E
V
Y
N
A
M
V
W
Y
T
K
L
R
Y
Y
L
M
P
Y
I
Y
T
L
G
G
D
T
Y
H
K
D
G
T
I
M
R
G
L
V
M
D
-
F
P
N
D
R
K
A
W
D
I
N
T
-----
Q
Y
M
F
G
P
A
F
L
V
N
P
V
Y
E
Y
K
A
R
S
R
D
V
Y
L
P
A
G
S
D
-
W
Y
N
F
Y
T
G
-
E
K
L
A
-
G
G
Q
T
I
T
A
D
A
P
L
A
R
V
P
L
F
V
K
A
G
A
I
V
P
T
--
G
-----
P
L
I
Q
H
V
D
------------
E
G
L
N
S
--
P
L
L
I
T
V
Y
T
G
---
A
---
N
--
G
S
F
D
I
Y
E
D
DGRSLK
Y
Q
Q
G
E
W
S
R
I
P
L
S
Y
---------
D
D
V
T
G
T
L
I
I
GDRVG
S
F
T
G
M
A
D
E
R
N
I
R
V
R
F
I
A
G
P
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.79
26%
-47
- C1 -
2XVG
9
?
A:
[403-962]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
D
Y
Y
F
V
A
G
D
T
K
D
D
I
I
S
G
Y
R
Q
L
T
G
K
S
V
M
L
P
K
W
A
Y
G
F
W
Q
S
R
E
---
R
Y
K
--
S
--
S
D
E
I
I
Q
N
L
K
E
Y
R
D
R
K
I
P
I
D
N
I
V
L
D
--------
W
S
------
Y
W
P
E
D
A
W
G
S
H
D
F
D
K
Q
F
------------
F
P
D
P
K
A
L
V
D
K
V
H
A
M
N
A
Q
I
M
I
S
V
W
P
K
F
Y
P
T
T
D
N
--
Y
K
E
L
-
N
A
K
G
F
M
F
N
R
N
L
D
E
K
N
------------
L
D
W
I
G
---------------------
K
---
G
Y
L
N
A
F
Y
D
P
F
S
P
E
A
T
A
I
F
W
K
Q
I
R
D
K
I
N
V
-------
H
-
G
F
D
A
W
W
---
L
D
---------------------------
A
V
E
P
-
D
I
-
H
S
--------------------------------
N
L
-----------------------------------
T
-------
F
--
E
K
R
--
K
W
L
M
TPNARG
N
---------
G
A
--------------------------------
E
I
F
N
A
Y
A
V
P
H
A
E
G
V
Y
Q
G
E
L
A
T
--
D
G
D
--
K
--
R
S
F
I
L
T
R
S
G
F
G
G
I
Q
R
-
T
G
S
A
I
-
W
S
G
D
I
V
S
R
W
S
D
M
K
D
Q
I
A
A
G
I
G
T
N
L
A
G
V
T
N
W
T
F
D
I
G
G
F
----------------------
T
PEDRFRHGKKGFV
G
S
-----
W
----------------------
T
A
L
DAEQ
V
D
E
W
Q
E
L
N
T
R
W
Y
Q
F
G
A
F
V
P
L
Y
R
S
H
G
Q
----------
N
P
Y
R
E
I
F
N
I
A
D
E
GT
E
V
Y
N
A
M
V
W
Y
T
K
L
R
Y
Y
L
M
P
Y
I
Y
T
L
G
G
D
T
Y
H
K
D
G
T
I
M
R
G
L
V
M
D
-
F
P
N
D
R
K
A
W
D
I
N
T
-----
Q
Y
M
F
G
P
A
F
L
V
N
P
V
Y
E
Y
K
A
R
S
R
D
V
Y
L
P
A
G
S
D
-
W
Y
N
F
Y
T
G
-
E
K
L
A
-
G
G
Q
T
I
T
A
D
A
P
L
A
R
V
P
L
F
V
K
A
G
A
I
V
P
T
--
G
-----
P
L
I
Q
H
V
D
------------
E
G
L
N
S
--
P
L
L
I
T
V
Y
T
G
---
A
---
N
--
G
S
F
D
I
Y
E
D
DGRSLK
Y
Q
Q
G
E
W
S
R
I
P
L
S
Y
---------
D
D
V
T
G
T
L
I
I
GDRVG
S
F
T
G
M
A
D
E
R
N
I
R
V
R
F
I
A
G
P
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.57
26%
-46
- C1 -
2XVK
6
?
A:
[403-962]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
D
Y
Y
F
V
A
G
D
T
K
D
D
I
I
S
G
Y
R
Q
L
T
G
K
S
V
M
L
P
K
W
A
Y
G
F
W
Q
S
R
E
---
R
Y
K
--
S
--
S
D
E
I
I
Q
N
L
K
E
Y
R
D
R
K
I
P
I
D
N
I
V
L
D
--------
W
S
------
Y
W
P
E
D
A
W
G
S
H
D
F
D
K
Q
F
------------
F
P
D
P
K
A
L
V
D
K
V
H
A
M
N
A
Q
I
M
I
S
V
W
P
K
F
Y
P
T
T
D
N
--
Y
K
E
L
-
N
A
K
G
F
M
F
N
R
N
L
D
E
K
N
------------
L
D
W
I
G
---------------------
K
---
G
Y
L
N
A
F
Y
D
P
F
S
P
E
A
T
A
I
F
W
K
Q
I
R
D
K
I
N
V
-------
H
-
G
F
D
A
W
W
---
L
D
---------------------------
A
V
E
P
-
D
I
-
H
S
--------------------------------
N
L
-----------------------------------
T
-------
F
--
E
K
R
--
K
W
L
M
TPNARG
N
---------
G
A
--------------------------------
E
I
F
N
A
Y
A
V
P
H
A
E
G
V
Y
Q
G
E
L
A
T
--
D
G
D
--
K
--
R
S
F
I
L
T
R
S
G
F
G
G
I
Q
R
-
T
G
S
A
I
-
W
S
G
D
I
V
S
R
W
S
D
M
K
D
Q
I
A
A
G
I
G
T
N
L
A
G
V
T
N
W
T
F
D
I
G
G
F
----------------------
T
PE
D
R
F
R
H
GKKGFV
G
S
-----
W
----------------------
T
A
L
DAEQ
V
D
E
W
Q
E
L
N
T
R
W
Y
Q
F
G
A
F
V
P
L
Y
R
S
H
G
Q
----------
N
P
Y
R
E
I
F
N
I
A
D
E
GT
E
V
Y
N
A
M
V
W
Y
T
K
L
R
Y
Y
L
M
P
Y
I
Y
T
L
G
G
D
T
Y
H
K
D
G
T
I
M
R
G
L
V
M
D
-
F
P
N
D
R
K
A
W
D
I
N
T
-----
Q
Y
M
F
G
P
A
F
L
V
N
P
V
Y
E
Y
K
A
R
S
R
D
V
Y
L
P
A
G
S
D
-
W
Y
N
F
Y
T
G
-
E
K
L
A
-
G
G
Q
T
I
T
A
D
A
P
L
A
R
V
P
L
F
V
K
A
G
A
I
V
P
T
--
G
-----
P
L
I
Q
H
V
D
------------
E
G
L
N
S
--
P
L
L
I
T
V
Y
T
G
---
A
---
N
--
G
S
F
D
I
Y
E
D
DGRSLK
Y
Q
Q
G
E
W
S
R
I
P
L
S
Y
---------
D
D
V
T
G
T
L
I
I
GDRVG
S
F
T
G
M
A
D
E
R
N
I
R
V
R
F
I
A
G
P
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
55.32
27%
-39
- C1 -
1XSJ
2
XYLS_ECOLI
A:
[93-675]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
N
T
E
R
Y
A
E
F
K
S
G
N
L
S
A
R
V
S
K
G
E
F
-
W
S
L
D
F
L
R
-
N
-
G
--
E
R
I
T
G
S
Q
V
K
--
N
N
--
G
Y
V
Q
-
D
T
N
N
Q
R
N
Y
M
F
E
R
L
D
L
G
V
G
E
T
V
Y
G
L
G
E
R
F
-
T
A
L
V
R
---
N
G
Q
T
V
E
T
W
-------
N
R
D
G
-
G
T
S
T
E
Q
A
Y
K
N
I
P
F
Y
M
T
-----
N
R
----
G
-----
Y
G
V
L
V
N
H
P
Q
C
V
S
F
E
V
G
S
E
K
-
V
S
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
Q
F
S
V
E
S
E
-----------------
Y
L
------
E
Y
F
V
I
D
G
P
T
P
K
A
V
L
D
R
Y
T
R
F
T
G
R
P
A
L
P
P
A
W
S
F
G
L
W
L
T
T
S
FTT
N
Y
D
-----
E
A
T
V
N
S
F
I
D
G
M
A
E
R
N
L
P
L
H
V
F
H
F
D
CFWMKAF
Q
W
C
D
--------------------
F
E
W
D
P
L
T
F
------
P
D
P
E
G
M
I
R
R
L
K
A
K
G
L
K
I
C
V
W
I
N
P
Y
I
G
Q
K
S
P
V
--
F
K
E
-------
L
Q
E
K
G
Y
L
L
K
R
P
D
-
G
-
S
L
W
Q
--
W
D
K
W
Q
P
---------------------
G
---
L
A
I
Y
----
D
F
T
N
P
D
A
C
K
W
Y
A
D
K
L
K
G
L
V
A
--------
M
G
V
D
C
F
K
---
T
D
---------------------------
F
G
E
R
-
I
--
P
T
--------------------------------
D
V
-----------------------------------
Q
-------
W
--
F
D
G
--
S
---------
D
---------
P
Q
--------------------------------
K
M
H
N
H
Y
A
Y
I
Y
N
E
L
V
W
N
V
L
K
D
T
VG
E
E
E
--
A
--
V
L
F
--
A
R
S
A
S
V
G
A
Q
K
-
F
P
-
V
H
-
W
G
G
D
C
Y
A
N
Y
E
S
M
A
E
S
L
R
G
G
L
S
I
G
L
S
G
F
G
F
W
S
H
D
I
G
G
F
----------------------
E
-------------
N
T
-----
A
----------------------
P
-
A
---------
H
V
Y
K
R
W
C
A
F
G
L
L
S
S
H
S
R
L
H
G
S
K
S
------
Y
R
V
P
W
---
A
Y
D
D
E
S
--
C
D
V
V
R
F
F
T
Q
L
K
C
R
M
--
M
P
Y
L
Y
R
E
A
A
R
A
N
A
R
G
T
P
M
M
R
A
M
M
M
E
-
F
P
D
D
P
A
C
D
Y
L
D
R
-----
Q
Y
M
L
G
D
N
V
M
V
A
P
V
F
T
E
A
-
G
D
V
Q
F
Y
L
P
E
G
-
R
-
W
T
H
L
W
H
N
-
D
E
L
D
-
G
S
R
W
H
K
Q
Q
H
G
F
L
S
L
P
V
Y
V
R
D
N
T
L
L
A
L
--
G
N
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
54.57
20%
-21
- C1 -
2XVL
12
?
A:
[45-988]
A
L
A
Q
V
E
R
T
A
E
G
V
V
L
T
L
P
E
G
TVK
K
L
R
L
Q
V
M
G
E
R
I
I
R
V
T
A
L
P
G
T
D
F
G
I
V
P
E
S
I
Q
V
V
A
K
P
A
T
N
V
P
F
S
V
D
Q
A
G
E
K
L
V
L
K
T
SQ
V
S
A
E
V
S
L
L
D
G
T
V
S
F
R
D
A
K
G
N
V
L
L
Q
E
ENR
G
T
F
S
P
V
I
H
D
P
D
P
V
D
A
D
S
Y
A
L
R
Q
E
F
N
R
G
S
D
E
G
F
F
G
L
G
Q
H
Q
N
G
Q
V
N
Y
A
G
E
N
V
E
L
T
T
Y
N
L
V
I
S
I
P
F
L
V
S
S
R
N
Y
G
L
L
W
D
N
N
S
I
T
R
F
G
D
P
R
E
A
Q
P
L
N
Q
S
L
K
L
Y
D
A
E
G
K
E
G
G
L
------
T
-----
V
-
R
---
Y
-----
F
V
G
D
E
L
K
L
T
R
V
E
A
D
F
N
H
Q
F
Y
K
Q
G
N
E
L
E
N
P
F
-
P
E
E
V
A
G
A
-
Y
-
K
--
N
N
-
T
L
R
I
E
L
--
E
G
S
I
E
A
Q
A
-
T
G
K
H
Q
F
K
M
Y
N
S
-------------
G
Y
A
Q
-
L
S
L
D
G
---
E
V
V
L
D
R
W
R
M
NW
N
--
P
W
Y
H
N
-
F
Y
R
E
L
N
A
G
D
K
H
K
L
K
V
S
-----
W
K
----
P
-----
D
G
G
F
F
H
L
R
H
L
D
P
L
P
A
N
E
Q
H
-
E
L
-------------------------------------------------------------
S
----------------------------------------------------------------------------------------
L
A
S
E
T
G
K
------------------
A
I
------
D
Y
Y
F
V
A
G
D
T
K
D
D
I
I
S
G
Y
R
Q
L
T
G
K
S
V
M
L
P
K
W
A
Y
G
F
W
Q
S
R
E
---
R
Y
K
--
S
--
S
D
E
I
I
Q
N
L
K
E
Y
R
D
R
K
I
P
I
D
N
I
V
L
D
-------
W
-------------
S
Y
W
P
E
D
A
W
G
S
H
D
F
D
-----
K
-
Q
F
F
P
D
P
K
A
L
V
D
K
V
H
A
M
N
A
Q
I
M
I
S
V
W
P
K
F
Y
P
T
T
D
N
--
Y
K
E
L
N
A
K
G
F
M
F
N
R
N
L
D
E
K
N
L
D
W
-
I
-
G
K
G
Y
-----------------------------
L
---
N
A
F
Y
----
D
P
F
S
P
E
A
T
A
I
F
W
K
Q
I
R
D
K
I
N
-------
V
H
G
F
D
A
W
W
---
L
D
---------------------------
A
V
E
P
-
D
I
-
H
S
--------------------------------
N
L
-----------------------------------
T
-------
F
--
E
K
R
--
K
---------
W
L
M
TPNARGN
G
A
--------------------------------
E
I
F
N
A
Y
A
V
P
H
A
E
G
V
Y
Q
G
E
L
A
T
--
D
G
D
K
R
S
--
F
I
L
--
T
R
S
G
F
G
G
I
Q
R
T
G
S
-
A
I
-
W
S
G
D
I
V
S
R
W
S
D
M
K
D
Q
I
A
A
G
I
G
T
N
L
A
G
V
T
N
W
T
F
D
I
G
G
F
TPEDRFRHGKKGFVGSWTALDA
E
-------------
Q
V
-----
D
----------------------
E
W
Q
---------
E
L
N
T
R
W
Y
Q
F
G
A
F
V
P
L
Y
R
S
H
G
Q
N
P
Y
------
R
E
I
F
N
I
A
D
E
--
G
T
--
E
V
Y
N
A
M
V
W
Y
T
K
L
R
Y
Y
L
M
P
Y
I
Y
T
L
G
G
D
T
Y
H
K
D
G
T
I
M
R
G
L
V
M
D
-
F
P
N
D
R
K
A
W
D
I
N
T
-----
Q
Y
M
F
G
P
A
F
L
V
N
P
V
Y
E
Y
K
A
R
S
R
D
V
Y
L
P
A
G
-
S
D
W
Y
N
F
Y
T
G
-
E
K
L
A
-
G
G
Q
T
I
T
A
D
A
P
L
A
R
V
P
L
F
V
K
A
G
A
I
V
P
T
--
G
P
L
I
Q
H
-------------------
V
D
E
G
L
N
S
P
L
L
I
T
V
Y
T
G
---
A
---
N
--
G
S
F
D
I
Y
E
D
------------------------------------------------------------------
D
G
R
S
----------------
L
K
Y
Q
Q
-
G
E
W
S
R
I
P
L
S
Y
D
D
V
T
G
T
L
I
I
G
D
R
V
G
-----------------------------
S
F
T
G
M
A
D
E
R
N
I
R
V
R
F
I
A
G
P
T
A
D
A
T
N
F
D
-----
K
A
A
A
E
A
V
T
Y
T
G
K
S
V
S
I
K
R
P
R
--------------------------------------------
46
HHSearch
54.19
19%
-30
- C1 -
3TOP
1
MGA_HUMAN
A:
[88-809]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
D
V
T
Y
H
K
N
E
M
L
Q
F
K
I
Y
D
P
N
K
N
------
R
-----
Y
-
E
---
V
-----
P
V
P
-
L
N
I
P
-
S
M
P
S
S
T
P
E
G
Q
L
Y
D
V
L
I
K
K
N
P
F
-
G
I
E
I
R
R
K
-
S
T
G
--
T
I
I
W
D
S
Q
----
L
L
G
F
T
F
S
-------
D
M
F
I
R
I
S
T
R
L
P
-
S
K
Y
L
Y
G
F
G
E
T
E
-
H
R
S
Y
R
---
R
D
L
E
W
H
T
W
G
--
M
--
F
S
R
D
Q
P
P
G
Y
K
K
N
S
Y
G
V
H
P
Y
Y
M
G
-----
L
E
EDG
S
A
-----
H
G
V
L
L
L
N
S
N
A
M
D
V
T
F
Q
P
L
P
----------------------------------------------------------------
A
----------------------------------------------------------------------------------------
L
T
Y
R
T
-----------------
T
G
G
V
L
------
D
F
Y
V
F
L
G
P
T
P
E
L
V
T
Q
Q
Y
T
E
L
I
G
R
P
V
M
V
P
Y
W
S
L
G
F
Q
L
C
R
Y
---
G
Y
Q
--
N
--
D
S
E
I
A
S
L
Y
D
E
M
V
A
A
Q
I
P
Y
D
V
Q
Y
--------------------
S
D
I
D
Y
M
E
-------
R
Q
L
D
F
T
L
S
P
--
K
F
A
G
F
P
A
L
I
N
R
M
K
A
D
G
M
R
V
I
L
I
L
D
P
A
I
S
G
N
E
T
---
Q
P
Y
P
A
F
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--
G
V
E
D
D
V
F
I
K
Y
P
N
D
G
-
D
I
V
W
G
K
--
V
W
P
D
FPDVVVNGSLD
W
D
S
Q
V
E
L
YR
A
Y
---
V
A
F
P
----
D
F
F
R
N
S
T
A
K
W
W
K
R
E
I
E
E
L
Y
N
NPQNPER
S
L
K
F
D
G
M
W
---
I
D
---------------------------
M
N
E
P
-
S
S
F
V
N
--------------------------------
G
A
VSPGCRDASLNHPPYMPHLESRDRGLSSKTLCME
S
Q
-------
Q
I
L
P
D
G
S
L
V
---------
Q
---------
H
Y
--------------------------------
N
V
H
N
L
Y
G
W
S
Q
T
R
P
T
Y
E
A
V
Q
E
V
T-
G
Q
R
--
G
--
V
V
I
--
T
R
S
T
F
P
S
S
G
R
-
W
A
-
G
H
-
W
L
G
D
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A
A
W
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L
K
K
S
I
I
G
M
M
E
F
S
L
F
G
I
S
Y
T
G
A
D
I
C
G
F
----------------------
F
-------------
Q
D
----------------------------
A
E
Y
---------
E
M
C
V
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
T
I
G
T
----
R
R
Q
D
P
V
S
W
D
V
A
-------
F
V
N
I
S
R
T
V
L
Q
T
R
Y
T
L
L
P
Y
L
Y
T
L
M
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K
A
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E
G
V
T
V
V
R
P
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L
H
E
-
F
V
S
D
Q
V
T
W
D
I
D
S
-----
Q
F
L
L
G
P
A
F
L
V
S
P
V
L
E
R
N
A
R
N
V
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A
-
R
-
W
Y
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-
V
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L
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A
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D
H
I
N
L
H
V
R
G
G
Y
I
L
P
W
--
Q
E
P
A
L
N
-------------------
T
H
L
S
R
Q
K
F
M
G
F
K
I
A
L
D
---
D
---
E
GT
A
G
G
W
L
F
W
D
------
D
G
--
Q
S
I
D
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Fugue
53.91
19%
-31
- C1 -
2QMJ
14
MGA_HUMAN
A:
[7-870]
----
V
N
E
L
E
R
---------------
I
N
C
I
P
D
Q
P
P
T
-------------------------------------------------------------
K
A
T
C
D
Q
R
----
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
V
N
T
N
A
G
---------------
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
---
S
N
R
F
H
F
K
L
T
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Q
T
N
N
R
F
E
V
P
---------------------------------
H
E
H
V
Q
S
F
S
G
N
A
A
A
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L
T
Y
Q
V
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F
-
S
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-
N
NR
V
L
F
D
S
S
I
-------------
G
P
L
L
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A
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Q
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L
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L
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T
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L
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S
T
N
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-
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Q
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---
H
D
M
N
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--
I
F
N
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D
T
T
P
-
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
-----
L
E
----
D
ASG
L
S
F
G
V
F
L
M
N
S
N
A
M
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V
V
L
Q
P
A
P
-
A
I
-------------------------------------------------------------
T
----------------------------------------------------------------------------------------
Y
R
T
I
-------------------
G
G
I
L
------
D
F
Y
V
F
L
G
N
T
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V
V
Q
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Y
L
E
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---
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--
T
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V
V
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R
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R
A
A
Q
L
P
Y
--------------------
D
V
Q
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A
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I
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Y
M
D
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R
R
-------
D
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-
D
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A
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S
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N
S
S
S
--
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M
K
I
W
V
N
S
S
D
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-
V
-
T
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L
--
I
G
E
V
W
P
G
---------------------
Q
---
T
V
F
P
----
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
-------
Q
V
E
F
D
G
I
W
---
I
D
---------------------------
M
N
E
V
-
S
N
-
F
V
--------------------------------
D
G
-----------------------------------
S
-------
V
--
S
G
C
--
S
---------
T
---------
N
N
LNNPPFTPRILDGYLFCKTLCMD
A
V
Q
HWGKQY
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
--
F
P
N
KR
S
--
F
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--
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R
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T
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A
G
S
G
K
-
F
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-
A
H
-
W
L
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D
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T
A
T
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D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
----------------------
A
-------------
L
D
----------------------------
T
P
E
---------
E
L
C
R
R
W
M
Q
L
G
A
F
Y
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R
N
H
N
G
Q
G
Y
K
D
----
Q
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P
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---
G
A
D
S
--
L
L
L
N
S
S
R
H
Y
L
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Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
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A
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P
L
L
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-
F
Y
E
D
N
S
T
W
D
V
H
Q
-----
Q
F
L
W
G
P
G
L
L
I
T
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V
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D
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A
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V
M
A
Y
V
P
D
A
-
V
-
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R
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Q
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V
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M
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L
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G
D
K
I
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L
H
L
R
G
G
Y
I
F
P
T
--
Q
---------------------------------------------------------------------------------------------------------
Q
P
N
T
T
T
L
A
-
S
R
K
N
P
L
G
L
I
I
A
---------
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
V
A
N
-----------
K
V
Y
L
L
C
E
F
S
V
T
Q
N
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
----------
A
F
N
E
I
K
I
L
G
T
E
E
P
S
N
V
T
V
K
H
N
---
G
V
P
S
T
S
P
T
V
T
Y
D
S
N
L
K
V
A
I
I
T
D
------------------------
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
H
-----
16
PsiBlast_PDB
53.66
23%
-45
- C1 -
4XPR
6
?
A:
[91-668]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
P
L
Q
K
E
E
Q
L
Y
G
F
G
L
N
F
-
Q
T
V
H
Q
---
R
G
K
I
L
E
L
H
V
------
D
H
Y
G
-
G
K
D
S
G
R
T
H
A
P
T
P
F
Y
V
S
-----
S
N
----
G
-----
Y
G
V
F
I
N
S
A
R
Y
I
K
V
W
A
G
T
G
V
R
K
D
-------------------------------------------------------------
S
----------------------------------------------------------------------------------------
E
N
F
P
T
P
K
D
RNTDKTWSSRPY
S
D
A
V
E
I
L
V
PAE
G
V
E
V
Y
V
F
G
G
P
K
P
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A
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N
L
L
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G
G
G
Y
L
P
P
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G
L
G
F
T
Q
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V
M
---
T
R
Y
--
T
--
D
K
D
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E
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K
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Y
P
L
D
F
V
G
L
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-------
P
G
--------
W
Q
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K
A
Y
P
G
-----
T
F
S
W
D
-----
K
-
S
R
Y
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D
P
T
S
F
V
K
K
M
K
D
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I
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L
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N
P
Y
I
S
P
D
A
P
F
--
Y
K
E
I
K
---------------------
P
Y
T
G
S
H
T
V
W
L
G
--------------------------
L
V
P
----
D
F
T
M
A
E
A
R
K
P
F
F
N
Q
L
L
K
D
Q
I
-------
E
R
G
V
S
G
Y
K
I
A
E
V
D
---------------------------
G
Y
D
Y
Y
L
W
-
P
D
--------------------------------
A
A
-----------------------------------
K
-------
F
--
P
S
G
--
L
---------
S
---------
A
E
--------------------------------
Q
M
R
Q
T
Y
G
L
L
V
Q
R
Y
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A
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--
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--
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--
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G
L
--
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G
G
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-
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V
-
I
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Y
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A
L
I
N
S
G
F
A
----
G
V
L
W
T
P
E
V
R
A
S
K
----------------------
S
-------------
G
-----------------------------------------
E
E
W
L
R
R
F
Q
S
N
V
F
S
P
M
A
M
I
N
A
W
A
S
G
------
T
K
P
W
S
Y
P
E
V
E
A
D
--------
V
K
K
F
A
L
L
R
M
Q
M
M
P
Y
W
Y
S
A
F
A
R
Y
H
F
E
G
M
P
P
F
R
G
M
G
L
E
E------------KEIKD
Q
Y
M
A
G
D
D
L
L
V
A
P
M
F
A
-
G
E
K
S
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K
V
V
L
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-
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-
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A
G
-
D
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L
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Y
V
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D
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V
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M
M
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A
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L
N
S
P
K
S
N
Q
K
V
--------------------
D
L
E
I
R
Y
Y
G
N
---
K
---
P
--
G
E
F
K
L
Y
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
53.48
20%
-31
- C1 -
3LPP
4
SUIS_HUMAN
A:
[112-807]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
L
F
T
T
Q
N
Q
T
P
N
R
F
R
F
K
I
T
D
P
N
N
R
------
R
-----
Y
-
E
---
V
-----
P
H
Q
---
Y
V
K
E
F
T
G
P
T
V
S
D
T
L
Y
D
V
K
V
A
Q
N
P
F
-
S
I
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V
I
R
K
S
N
-
G
--
K
T
L
F
D
T
S
----
I
G
P
L
V
Y
S
-------
D
Q
Y
L
Q
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S
A
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L
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-
S
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I
G
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--
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N
N
N
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Q
T
F
F
M
C
I
EDTS
G
K
----
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-----
F
G
V
F
L
M
N
S
N
A
M
E
I
F
I
Q
P
T
P
----------------------------------------------------------------
I
----------------------------------------------------------------------------------------
V
T
Y
R
V
-----------------
T
G
G
I
L
------
D
F
Y
I
L
L
G
D
T
P
E
Q
V
V
Q
Q
Y
Q
Q
L
V
G
L
P
A
M
P
A
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W
N
L
G
F
Q
L
S
R
W
---
N
Y
K
--
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--
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D
V
V
K
E
V
V
R
R
N
R
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A
G
I
P
F
D
T
Q
V
--------------------
T
D
I
D
Y
M
E
-------
D
K
K
D
F
T
Y
D
Q
-
V
A
F
N
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L
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Q
F
V
Q
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A
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T
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A
T
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--
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N
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Q
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V
W
I
N
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S
D
-
G
S
T
P
I
I
G
E
--
V
W
P
G
---------------------
L
---
T
V
Y
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----
D
F
T
N
P
N
C
I
D
W
W
A
N
E
C
S
I
F
H
Q
-------
E
V
Q
Y
D
G
L
W
---
I
D
---------------------------
M
N
E
V
-
S
S
F
I
Q
GSTKGCNVNKLNYPPFTPDILDKLMYSKTICM
D
A
-----------------------------------
V
-------
Q
---
N
W
--
G
---------
K
---------
Q
Y
--------------------------------
D
V
H
S
L
Y
G
Y
S
M
A
I
A
T
E
Q
A
V
Q
K
V
FP
N
K
R
--
S
--
F
I
L
--
T
R
S
T
F
A
G
S
G
R
-
H
A
-
A
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W
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F
S
L
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P
L
V
G
A
D
I
C
G
F
----------------------
V
-------------
A
E
----------------------------
T
T
E
---------
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
S
D
G
Y
----
E
H
Q
D
P
A
F
F
G
Q
N
S
-----
L
L
V
K
S
S
R
Q
Y
L
T
I
R
Y
T
L
L
P
F
L
Y
T
L
F
Y
K
A
H
V
F
G
E
T
V
A
R
P
V
L
H
E
-
F
Y
E
D
T
N
S
W
I
E
D
T
-----
E
F
L
W
G
P
A
L
L
I
T
P
V
L
K
Q
G
A
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T
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A
Y
I
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D
A
-
I
-
W
Y
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Y
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P
I
--
Q
E
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D
V
T
-------------------
T
T
A
S
R
K
N
P
L
G
L
I
V
A
L
G
---
E
NN-
T
--
A
K
G
D
F
F
W
D
------
D
G
--
E
T
K
D
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
53.26
20%
-32
- C1 -
2G3N
1
AGLU_SULSO
A:
[3-693]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
I
Y
E
N
K
G
V
Y
K
V
V
I
G
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P
F
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P
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Q
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-
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------
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--
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L
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Q
G
N
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V
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---
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H
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L
G
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---
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R
K
R
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M
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--
V
--
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I
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-----
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----
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G
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A
--
T
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Y
F
F
N
S
A
S
K
V
I
F
D
V
G
L
E
E
-
Y
D
-------------------------------------------------------------
K
----------------------------------------------------------------------------------------
V
I
V
T
I
P
E
-----------------
D
S
V
------
E
F
Y
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E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------