@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2458: (2016-04-03 )
MAKKVVTDLDLKDKKVLVRVDFNVPMKDGKITNDNRIVAALPTIEYILEQNGKAILFSHLGKVKTEEDKEGKSLRPVAVRLSELLGKEVKFVPTTRGPELEKAIDELKDGEVLLFENTRFEDIDGKKESKNDPELGKYWASLGDVFVNDAFGTAHRAHASNVGIASNLESAAGFLMEKEIKFIGGVVDNPARPLVAILGGAKVSDKIGVIENLLTKADKVLVGGGMTFTFMAAQGQEIGKSLLEADKVELAKGLLEKAGDKLVLPVDAVVSKEFSNDAPFHTVSADSIPADEMGLDIGQATIDLFTKELQGAKTVVWNGPMGVFELSNFAKGTIGVCEAIANLTDATTIIGGGDSAAAAMDLGFADKFTHISTGGGASLEYLEGKELPGVASISDK
Atome Classification :
(52 SA)
........-.-10........20.......-.30........40........50.-.-..-....60........70........80........90..-......-100.......110.......120------.--------....---.----------...130.-------.....---.140---.......150.......160......-.---170..-......180.......190.......200.......210...--.--...220.......230.-.-.....240..-------.-------....250......---.260--........270.......280-.-..-...-..290------.......300.......310.......320.......330.......340..--.--.--...350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKKVVTD-L-DLKD
K
K
V
L
V
R
V
D
FNVPMKD-GKITND
N
R
I
V
A
A
L
P
T
I
E
Y
I
L
EQNG-
K
-
A
I
-
L
F
S
H
LGKVKTEEDKEGKSL
R
P
V
A
V
R
L
S
E
L
LGKE
V
K
F
V
P-TTRGP
E
-
L
E
K
A
I
D
ELKDG
E
V
L
L
F
ENTRF--------E--------DIDG---K----------KESKND
P
-------
E
L
G
K
Y
---
W
A
S
L
---
G
D
V
F
V
NDAFGTAHRAHASNVGIAS
N
L
-
E
---
S
A
-
A
G
-
F
L
M
E
K
E
I
K
F
I
G
GVVDNPA
R
P
L
V
A
I
LGGAKV
S
D
K
I
G
V
I
E
N
L
L
T
--K--AD
K
V
L
VGGG
M
T
F
T
F
M
AA-Q-
G
Q
E
I
G
K
S
L
L
E
-------
A
-------
D
K
V
E
L
A
K
G
L
L
E
KA---G
D
K
---
L
V
L
P
V
D
A
V
V
S
K
EFSNDAP
F
-
H
-T-VS-ADS-I
P
A
D
E
------MGL
D
I
G
Q
A
T
I
D
L
F
T
K
E
LQG
A
K
T
V
V
WNGPM
G
V
F
E
L
S
N
FAK
G
T
I
G
V
C
E
A
I
A
NLT--D--
A
--
T
T
I
IGGGD
S
A
A
A
A
MDLGFADKF
T
H
ISTGGGA
S
L
E
YLEGKELPGVASISDK
1
PsiBlast_PDB
97.03
73%
-93
- C11 -
4DG5
-
PGK_STAAR
A:
[2-396]
-
A
K
K
I
V
S
D
-
L
-
D
L
K
G
K
T
V
L
V
R
A
D
F
N
V
P
L
K
D
-
G
E
I
T
N
D
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
E
Q
G
G
-
K
-
I
V
-
L
F
S
H
L
G
K
V
K
E
E
S
D
K
A
K
L
T
L
R
P
V
A
E
D
L
S
K
K
L
D
K
E
V
V
F
V
P
-
E
T
R
G
E
K
-
L
E
A
A
I
K
D
L
K
E
G
D
V
L
L
V
E
N
T
R
Y
--------
E
--------
D
L
D
G
---
K
----------
K
E
S
K
N
D
P
-------
E
L
G
K
Y
---
W
A
S
L
---
G
D
V
F
V
N
D
A
F
G
T
A
H
R
E
H
A
S
N
V
G
I
S
T
H
L
-
E
---
T
A
-
A
G
-
F
L
M
D
K
E
I
K
F
I
G
G
V
V
N
D
P
H
K
P
V
V
A
I
L
G
G
A
K
V
S
D
K
I
N
V
I
K
N
L
V
N
--
I
--
A
D
K
I
I
I
G
G
G
M
A
Y
T
F
L
K
A
-
Q
-
G
K
E
I
G
I
S
L
L
E
-------
E
-------
D
K
I
D
F
A
K
D
L
L
E
K
H
---
G
D
K
---
I
V
L
P
V
D
T
K
V
A
K
E
F
S
N
D
A
K
I
-
T
-
V
-
V
P
-
S
D
S
-
I
P
A
D
Q
------
E
G
M
D
I
G
P
N
T
V
K
L
F
A
D
E
L
E
G
A
H
T
V
V
W
N
G
P
M
G
V
F
E
F
S
N
F
A
Q
G
T
I
G
V
C
K
A
I
A
N
L
K
--
D
--
A
--
I
T
I
I
G
G
G
D
S
A
A
A
A
I
S
L
G
F
E
N
D
F
T
H
I
S
T
G
G
G
A
S
L
E
Y
L
E
G
K
E
L
P
G
I
K
A
I
N
N
K
2
PsiBlast_PDB
92.43
61%
-88
- C11 -
1VPE
3
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
G
E
P
S
P
E
F
-
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
-
A
V
V
G
D
E
-
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
---------------
P
----------
G
E
T
K
N
D
P
-------
E
L
A
K
F
---
W
A
S
L
---
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
---
S
V
-
A
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
E
--
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
S
S
R
V
E
-------
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
A
---
K
E
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
K
-
K
-
V
-
V
R
-
I
D
D
G
I
P
E
G
W
------
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
--
E
K
G
A
--
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
70
HHSearch
92.17
62%
-88
- C11 -
1VPE
3
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
G
E
P
S
-
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
-
A
V
V
G
D
E
-
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
--------
P
G
E
-----------------
T
K
N
D
P
-------
E
L
A
K
F
---
W
A
S
L
---
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
---
S
V
-
A
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
E
--
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
S
S
R
V
E
-------
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
A
K
E
-
K
G
V
E
--
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
K
-
K
-
V
V
R
I
-
D
D
G
-
I
P
E
G
W
------
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
E
K
G
--
A
--
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
66
HHSearch
90.54
55%
-90
- C11 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
-
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
G
K
V
V
-
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
-
E
A
V
G
D
E
-
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
--------
P
G
-----------------
E
E
K
N
D
P
-------
E
L
A
K
A
---
F
A
E
L
---
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
-
P
---
A
V
-
A
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
E
--
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
K
S
L
L
E
-------
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
A
K
E
-
K
G
V
R
--
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
T
-
K
-
V
-
V
P
-
I
D
A
-
I
P
A
D
W
------
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
E
A
L
--
D
--
T
--
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
3
PsiBlast_PDB
90.38
54%
-87
- C11 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
-
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
G
K
V
V
E
E
L
R
-
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
-
E
A
V
G
D
E
-
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
---------------
P
----------
G
E
E
K
N
D
P
-------
E
L
A
K
A
---
F
A
E
L
---
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
-
P
---
A
V
-
A
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
E
--
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
K
S
L
L
E
-------
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
A
K
E
K
G
V
R
---
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
T
-
K
-
V
-
V
P
-
I
D
A
-
I
P
A
D
W
------
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
E
A
L
--
D
--
T
--
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
41
PsiBlast_CBE
87.85
44%
-90
- C11 -
2P9T
1
PGK2_MOUSE
A:
[4-415]
-
A
K
L
T
L
D
K
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
-
D
C
V
G
P
E
-
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
S
S
G
---
K
----------
K
I
S
A
D
P
A
-------
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
D
--
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
-
G
-
Q
-
A
T
-
I
E
S
G
I
P
S
G
W
------
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
N
G
C
--
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
21
PsiBlast_CBE
87.43
49%
-87
- C11 -
1V6S
3
PGK_THET8
B:
[2-385]
---
R
T
L
L
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
P
D
P
K
--
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
-
F
P
P
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
---------------
P
----------
G
E
E
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
Y
-
A
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
-------
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
EAL
G
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
E
--
G
--
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
------
4
PsiBlast_PDB
87.42
49%
-88
- C11 -
1V6S
3
PGK_THET8
A:
[2-385]
---
R
T
L
L
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
P
D
P
K
--
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
-
F
P
P
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
---------------
P
----------
G
E
E
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
Y
-
A
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
-------
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
E
--
G
--
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
------
40
PsiBlast_CBE
87.22
44%
-92
- C11 -
2PAA
1
PGK2_MOUSE
A:
[4-415]
-
A
K
L
T
L
D
K
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
-
D
C
V
G
P
E
-
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
S
S
G
---
K
----------
K
I
S
A
D
P
A
-------
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
D
--
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
-
G
-
Q
-
A
T
-
I
E
S
G
I
P
S
G
W
------
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
N
G
C
--
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
69
HHSearch
87.07
49%
-88
- C11 -
1V6S
3
PGK_THET8
A:
[1-390]
--
M
R
T
L
L
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
P
D
--
P
K
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
R
F
A
P
-
F
P
P
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
--------
P
G
-----------------
E
E
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
Y
-
A
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
-------
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
-
L
G
V
R
--
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
E
--
G
--
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
-
68
HHSearch
87.05
48%
-87
* C11 *
3Q3V
5
PGK_CAMJE
A:
[6-399]
-
D
I
I
S
I
K
D
-
I
-
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
-
L
A
S
H
L
G
R
P
K
E
I
S
--
S
K
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
-
D
V
I
G
E
D
-
A
K
T
K
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--------
E
--------
K
G
-----------------
E
T
K
N
D
E
-------
N
L
A
K
E
---
L
A
S
M
---
V
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
-
D
EKH
K
G
-
A
G
-
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
P
--
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
Y
D
I
G
N
S
L
L
E
-------
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
G
K
N
-
L
G
V
K
--
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
M
-
K
-
F
-
V
P
-
A
Q
E
-
I
P
N
G
W
------
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
S
E
G
---
H
--
A
--
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
46
PsiBlast_CBE
86.76
45%
-96
- C11 -
3OZ7
2
PGK_PLAF7
A:
[10-417]
-----
I
S
D
-
L
K
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
S
K
-
I
I
-
L
I
S
H
C
G
R
P
D
G
L
R
N
-
E
K
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
L
F
L
N
-
D
C
V
G
K
E
-
V
E
D
K
I
N
A
A
K
E
N
S
V
I
L
L
E
N
L
R
F
--------
H
IEEEG
K
G
V
D
A
N
G
---
N
----------
K
V
K
A
N
K
E
-------
D
V
E
K
F
Q
N
D
L
T
K
L
---
A
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
L
N
V
-
K
----
A
-
S
G
-
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
K
N
L
L
D
--
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
K
K
V
L
N
-
N
M
K
I
G
T
S
L
F
D
-------
E
-------
A
G
S
K
I
V
G
E
I
M
E
K
A
---
K
A
K
N
V
Q
I
F
L
P
V
D
F
K
I
A
D
N
F
D
N
N
A
N
T
-
K
-
F
-
V
T
D
E
E
G
-
I
P
D
N
W
------
M
G
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
C
L
N
L
V
V
E
V
T
--
K
K
G
A
--
I
T
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
-
7
PsiBlast_PDB
86.74
49%
-90
- C11 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
-
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
Q
P
N
G
E
R
N
-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
-
D
C
V
G
P
E
-
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
IEEEG
S
R
-
K
V
D
G
---
Q
----------
K
V
K
A
S
K
E
-------
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
-
D
L
P
-
Q
---
R
A
-
A
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
D
--
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
D
S
I
F
D
-------
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
T
-
K
-
T
-
V
T
D
K
E
G
-
I
P
A
G
W
------
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
--
A
--
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
5
PsiBlast_PDB
86.65
49%
-89
- C11 -
2IE8
-
?
A:
[4-385]
-----
L
L
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
P
D
P
R
--
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
-
F
P
P
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
---------------
P
----------
G
E
E
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
Y
-
A
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
-------
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
E
--
G
--
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
------
13
PsiBlast_PDB
86.57
45%
-92
- C11 -
2X15
3
PGK1_HUMAN
A:
[2-415]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
----------------------------
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
16
PsiBlast_PDB
86.49
45%
-89
- C11 -
2XE6
1
PGK1_HUMAN
A:
[5-416]
--
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
19
PsiBlast_PDB
86.35
45%
-89
- C11 -
2YBE
5
PGK1_HUMAN
A:
[3-416]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
--------------------------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
35
PsiBlast_CBE
86.33
45%
-90
- C11 -
2ZGV
1
PGK1_HUMAN
A:
[6-419]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
37
PsiBlast_CBE
86.30
44%
-87
- C11 -
4O33
2
PGK1_HUMAN
A:
[3-416]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
34
PsiBlast_CBE
86.20
45%
-92
- C11 -
3C39
1
PGK1_HUMAN
A:
[6-419]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
----------------------------
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
15
PsiBlast_PDB
86.02
45%
-90
- C11 -
1VJD
2
PGK1_PIG
A:
[2-415]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
S
----------
K
V
K
A
D
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
43
PsiBlast_CBE
85.97
44%
-86
- C11 -
4O3F
2
PGK1_MOUSE
A:
[3-416]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
N
A
C
A
N
P
A
A
G
T
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
V
K
A
E
P
A
-------
K
I
D
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
Y
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
29
PsiBlast_CBE
85.84
45%
-93
- C11 -
3C3B
2
PGK1_HUMAN
B:
[6-419]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
-----
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
32
PsiBlast_CBE
85.81
45%
-89
- C11 -
3C3A
1
PGK1_HUMAN
A:
[6-419]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
48
PsiBlast_CBE
85.74
44%
-88
- C11 -
1HDI
3
PGK1_PIG
A:
[8-412]
---------
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
S
P
M
P
D
K
Y
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
L
F
L
K
-
D
C
V
G
P
A
-
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
A
A
G
E
P
A
-------
K
I
K
A
F
---
R
A
S
L
S
A
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
K
K
-
A
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
A
G
K
K
I
V
K
N
L
M
S
K
A
A
A
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
Q
A
K
I
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
18
PsiBlast_PDB
85.63
45%
-88
- C11 -
2XE8
2
PGK1_HUMAN
A:
[5-416]
--
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
---
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
20
PsiBlast_PDB
85.47
45%
-91
- C11 -
3ZOZ
5
PGK1_HUMAN
A:
[3-416]
L
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG-------------------------------
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
---
K
A
-
G
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
--
S
R
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
36
PsiBlast_CBE
85.43
44%
-89
- C11 -
1KF0
3
PGK1_PIG
A:
[2-415]
L
S
N
K
L
T
L
D
K
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
S
P
M
P
D
K
Y
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
-
D
C
V
G
P
E
-
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K