@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2462: (2016-04-03 )
MRVIDTHCDALYKLQAGKGKYTFQDAEELDVNFERLIEAKMLLQGFAIFLDEDIPVEHKWKKAVEQVNIFKQHVLHKGGIIHHVKKWCDLENLPEDKIGAMLTLEGIEPIGRDLDKLTQLLDGGVLSVGLTWNNANLAADGIMEERGAGLTRFGKDIIHLLNERKVFTDVSHLSVKAFWETLEQAEFVIASHSSAKAICAHPRNLDDEQIKAMIEHDAMIHVIFHPLFTTNDGVADIEDVIRHIDHICELGGMKNIGFGSDFDGIPDHVKGLEHAGKYQNFLETLGKHYTKEEVEGFASRNFLNHLPK
Atome Classification :
(20 SA)
-------------.........10......------..-20---.------..---.--.--....30........40........50...-..-----------------------...60---.........70........80........90...-.-..-...100.......110.......120.......130-----........140.------.--------...-.------.150.......160.......170.......180.....-.-.190.......200.......210.......220.......230---------------------------------------.--------------------------------------------------------......240.......250.......260.......270.......280-....-..-.290.......300......---------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------M
R
V
I
D
T
HC
D
A
L
Y
K
LQAG------KG-
K
----
Y
------TF---Q--
D
--
A
E
E
L
D
V
N
F
E
R
L
I
E
A
K
M
L
L
Q
G
F
A
I
F
LDEDI-PV-----------------------
E
H
K
W
----
K
K
A
V
E
Q
V
N
I
F
K
Q
H
V
L
HKG
G
I
I
H
H
V
K
K
W
CDL-ENL-P-ED-KI
G
A
M
L
T
LEGI
E
P
I
G
R
D
L
D
K
L
T
Q
L
LDG
G
V
L
S
V
G
L
T
------WNNANLAAD
G
I
M
------
E
--------ERG-A------
G
L
T
R
F
G
K
D
I
I
H
L
L
NE
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
L
E
Q
A
E
F
-
V
-
I
ASHSSA
K
A
I
CAHPRNL
D
D
E
Q
I
K
A
M
I
EHD
A
M
I
H
V
I
F
H
P
LFTTND---------------------------------------G--------------------------------------------------------
V
A
D
I
E
D
V
I
R
H
I
D
H
I
C
E
LGGMKNIGFGSDFDG
I
P
D
H
V
K
G
L
E
H
A
G
K
Y
Q
N
F
L
-
E
T
L
G
-
K
H-Y
T
K
E
E
V
E
G
F
A
S
R
N
F
L
N
HLPK---------------------------------
2
PsiBlast_PDB
99.01
98%
-115
- C4 -
3LU2
2
?
A:
[5-311]
--------------
R
V
I
D
T
H
C
D
A
L
Y
K
L
Q
A
G
------
K
G
-
K
----
Y
------
T
F
---
Q
--
D
--
A
E
E
L
D
V
N
F
E
R
L
I
E
A
K
M
L
L
Q
G
F
A
I
F
L
D
E
D
I
-
P
V
-----------------------
E
H
K
W
----
K
K
A
V
E
Q
V
N
I
F
K
Q
H
V
L
H
K
G
G
I
I
H
H
V
K
K
W
C
D
L
-
E
N
L
-
P
-
E
D
-
K
I
G
A
M
L
T
L
E
G
I
E
P
I
G
R
D
L
D
K
L
T
Q
L
L
D
G
G
V
L
S
V
G
L
T
------
W
N
N
A
N
L
A
A
D
G
I
M
------
E
--------
E
R
G
-
A
------
G
L
T
R
F
G
K
D
I
I
H
L
L
N
E
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
L
E
Q
A
E
F
-
V
-
I
A
S
H
S
S
A
K
A
I
C
A
H
P
R
N
L
D
D
E
Q
I
K
A
M
I
E
H
D
A
M
I
H
V
I
F
H
P
L
F
T
T
N
D
---------------------------------------
G
--------------------------------------------------------
V
A
D
I
E
D
V
I
R
H
I
D
H
I
C
E
L
G
G
M
K
N
I
G
F
G
S
D
F
D
G
I
P
D
H
V
K
G
L
E
H
A
G
K
Y
Q
N
F
L
-
E
T
L
G
-
K
H
-
Y
T
K
E
E
V
E
G
F
A
S
R
N
F
L
N
H
L
P
K
---------------------------------
21
PsiBlast_CBE
98.50
96%
-117
- C4 -
3NEH
3
?
B:
[3-310]
-------------
L
R
V
I
D
T
H
C
D
A
L
Y
K
L
Q
A
G
------
K
G
-
K
----
Y
------
T
F
---
Q
--
D
--
A
E
E
L
D
V
N
F
E
R
L
I
E
A
K
M
L
L
Q
G
F
A
I
F
L
D
E
D
I
-
P
V
-----------------------
E
H
K
W
----
K
K
A
V
E
Q
V
N
I
F
K
Q
H
V
L
H
K
G
G
I
I
H
H
V
K
K
W
C
D
L
-
E
N
L
-
P
-
E
D
-
K
I
G
A
M
L
T
L
E
G
I
E
P
I
G
R
D
L
D
K
L
T
Q
L
L
D
G
G
V
L
S
V
G
L
T
------
W
N
N
A
N
L
A
A
D
G
I
M
------
E
--------
E
R
G
-
A
------
G
L
T
R
F
G
K
D
I
I
H
L
L
N
E
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
L
E
Q
A
E
F
-
V
-
I
A
S
H
S
N
A
K
A
I
C
S
H
P
R
N
L
D
D
E
Q
I
K
A
M
I
E
H
D
A
M
I
H
V
V
F
Y
P
L
F
T
T
N
N
---------------------------------------
G
--------------------------------------------------------
V
A
D
T
E
D
V
I
R
H
I
D
H
I
C
E
L
G
G
L
K
N
I
G
F
G
S
D
F
D
G
I
P
D
H
V
K
G
L
E
H
V
G
K
Y
Q
S
F
L
-
E
T
L
E
-
K
H
-
Y
T
K
E
E
I
E
G
F
A
S
R
N
F
L
N
H
L
P
K
---------------------------------
1
PsiBlast_PDB
98.00
96%
-115
- C4 -
3NEH
3
?
A:
[3-310]
-------------
L
R
V
I
D
T
H
C
D
A
L
Y
K
L
Q
A
G
------
K
G
-
K
----
Y
------
T
F
---
Q
--
D
--
A
E
E
L
D
V
N
F
E
R
L
I
E
A
K
M
L
L
Q
G
F
A
I
F
L
D
E
D
I
-
P
V
-----------------------
E
H
K
W
----
K
K
A
V
E
Q
V
N
I
F
K
Q
H
V
L
H
K
G
G
I
I
H
H
V
K
K
W
C
D
L
-
E
N
L
-
P
-
E
D
-
K
I
G
A
M
L
T
L
E
G
I
E
P
I
G
R
D
L
D
K
L
T
Q
L
L
D
G
G
V
L
S
V
G
L
T
------
W
N
N
A
N
L
A
A
D
G
I
M
------
E
--------
E
R
G
-
A
------
G
L
T
R
F
G
K
D
I
I
H
L
L
N
E
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
L
E
Q
A
E
F
-
V
-
I
A
S
H
S
N
A
K
A
I
C
S
H
P
R
N
L
D
D
E
Q
I
K
A
M
I
E
H
D
A
M
I
H
V
V
F
Y
P
L
F
T
T
N
N
---------------------------------------
G
--------------------------------------------------------
V
A
D
T
E
D
V
I
R
H
I
D
H
I
C
E
L
G
G
L
K
N
I
G
F
G
S
D
F
D
G
I
P
D
H
V
K
G
L
E
H
V
G
K
Y
Q
S
F
L
-
E
T
L
E
-
K
H
-
Y
T
K
E
E
I
E
G
F
A
S
R
N
F
L
N
H
L
P
K
---------------------------------
22
HHSearch
97.52
96%
-113
- C4 -
3NEH
3
?
A:
[3-310]
-------------
L
R
V
I
D
T
H
C
D
A
L
Y
K
L
Q
A
G
------
K
G
-
K
----
Y
------
T
F
---
Q
--
D
--
A
E
E
L
D
V
N
F
E
R
L
I
E
A
K
M
L
L
Q
G
F
A
I
F
L
D
E
D
I
-
P
V
-----------------------
E
H
K
W
----
K
K
A
V
E
Q
V
N
I
F
K
Q
H
V
L
H
K
G
G
I
I
H
H
V
K
K
W
C
D
L
-
E
N
L
-
P
-
E
D
-
K
I
G
A
M
L
T
L
E
G
I
E
P
I
G
R
D
L
D
K
L
T
Q
L
L
D
G
G
V
L
S
V
G
L
T
------
W
N
N
A
N
L
A
A
D
G
I
M
------
E
--------
E
R
G
-
A
------
G
L
T
R
F
G
K
D
I
I
H
L
L
N
E
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
L
E
Q
A
E
--
F
V
I
A
S
H
S
N
A
K
A
I
C
S
H
P
R
N
L
D
D
E
Q
I
K
A
M
I
E
H
D
A
M
I
H
V
V
F
Y
P
L
F
T
T
N
N
---------------------------------------
G
--------------------------------------------------------
V
A
D
T
E
D
V
I
R
H
I
D
H
I
C
E
L
G
G
L
K
N
I
G
F
G
S
D
F
D
G
I
P
D
H
V
K
G
L
E
H
V
G
K
Y
Q
S
F
L
-
E
T
L
E
-
K
H
-
Y
T
K
E
E
I
E
G
F
A
S
R
N
F
L
N
H
L
P
K
---------------------------------
42
Fugue
72.51
26%
-89
- C4 -
1ITU
5
DPEP1_HUMAN
A:
[1-369]
D
F
F
R
D
E
A
E
R
I
M
R
D
S
P
V
I
D
G
H
N
D
L
P
W
Q
L
L
D
M
FNNRLQ
D
E
-
R
----
A
------
N
L
---
T
--
T
--
L
A
G
T
H
T
N
I
P
K
L
R
A
G
F
V
G
G
Q
F
W
S
V
Y
T
P
C
D
T
-
Q
N
-----------------------
K
D
A
V
----
R
R
T
L
E
Q
M
D
V
V
H
R
M
C
R
M
Y
P
E
T
F
L
Y
V
T
S
S
A
G
I
-
R
Q
A
-
F
-
R
E
G
K
V
A
S
L
I
G
V
E
G
G
H
S
I
D
S
S
L
G
V
L
R
A
L
Y
Q
L
G
M
R
Y
L
T
L
T
------
H
S
C
N
T
P
W
A
D
N
W
L
------
V
--------
D
T
G
-
D
SEPQSQ
G
L
S
P
F
G
Q
R
V
V
K
E
L
N
R
L
G
V
L
I
D
L
A
H
V
S
V
A
T
M
K
A
T
L
Q
L
S
R
A
P
V
-
I
F
S
H
S
S
A
Y
S
V
C
A
S
R
R
N
V
P
D
D
V
L
R
L
V
K
Q
T
D
S
L
V
M
V
N
F
Y
N
N
Y
I
S
C
T
---------------------------------------
N
--------------------------------------------------------
K
A
N
L
S
Q
V
A
D
H
L
D
H
I
K
E
V
A
G
A
R
A
V
G
F
G
G
D
F
D
G
V
P
R
V
P
E
G
L
E
D
V
S
K
Y
P
D
L
I
-
A
E
L
L
-
R
R
N
W
T
E
A
E
V
K
G
A
L
A
D
N
L
L
R
V
F
E
A
V
E
Q
A
SNLTQAPEEEPIPLDQLGGSC
R
T
H
Y
GYSS
28
HHSearch
71.45
27%
-83
- C4 -
1ITU
5
DPEP1_HUMAN
A:
[14-336]
-------------
S
P
V
I
D
G
H
N
D
L
P
W
Q
L
L
D
M
------
F
N
-
N
----
R
LQDERA
N
L
---
T
--
T
--
L
A
G
T
H
T
N
I
P
K
L
R
A
G
F
V
G
G
Q
F
W
S
V
Y
T
P
C
D
T
-
Q
N
-----------------------
K
D
A
V
----
R
R
T
L
E
Q
M
D
V
V
H
R
M
C
R
M
Y
P
E
T
F
L
Y
V
T
S
S
A
G
I
-
R
Q
A
-
F
R
E
G
-
K
V
A
S
L
I
G
V
E
G
G
H
S
I
D
S
S
L
G
V
L
R
A
L
Y
Q
L
G
M
R
Y
L
T
L
T
------
H
S
C
N
T
P
W
A
D
N
W
L
V
D
T
GDS
E
--------
P
Q
S
-
Q
------
G
L
S
P
F
G
Q
R
V
V
K
E
L
N
R
L
G
V
L
I
D
L
A
H
V
S
V
A
T
M
K
A
T
L
Q
L
S
R
A
-
P
V
I
F
S
H
S
S
A
Y
S
V
C
A
S
R
R
N
V
P
D
D
V
L
R
L
V
K
Q
T
D
S
L
V
M
V
N
F
Y
N
N
Y
I
S
C
T
---------------------------------------
N
--------------------------------------------------------
K
A
N
L
S
Q
V
A
D
H
L
D
H
I
K
E
V
A
G
A
R
A
V
G
F
G
G
D
F
D
G
V
P
R
V
P
E
G
L
E
D
V
S
K
Y
P
D
L
I
-
A
E
L
L
R
R
N
-
W
T
E
A
E
V
K
G
A
L
A
D
N
L
L
R
V
F
E
A
---------------------------------
9
PsiBlast_PDB
69.83
24%
-90
- C4 -
3S2J
8
?
A:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
7
PsiBlast_PDB
69.76
24%
-92
- C4 -
3ITC
4
?
A:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
11
PsiBlast_PDB
69.65
24%
-91
- C4 -
3S2M
9
?
A:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
26
HHSearch
69.39
26%
-89
- C4 -
3ID7
3
?
A:
[14-368]
-------------
F
P
V
V
D
G
H
N
D
L
P
W
A
L
R
E
Q
------
V
R
-
Y
DLDA
R
------
D
I
---
A
--
A
DQ
S
A
H
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
--------------------------
P
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
-
R
A
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
D-----
E
--------
P
G
V
-
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
-
P
V
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
--------------------------------------------------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
-
A
E
L
L
D
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
D
A
---------------------------------
8
PsiBlast_PDB
69.32
24%
-91
- C4 -
3ISI
3
?
X:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
VDWTAEADDNMRAHGFHHLDSSPEAMKVHAAFEERVPRP-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
12
PsiBlast_PDB
69.19
24%
-91
- C4 -
3S2N
9
?
A:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
10
PsiBlast_PDB
68.99
24%
-91
- C4 -
3S2L
14
?
A:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
6
PsiBlast_PDB
68.65
24%
-92
- C4 -
3K5X
3
?
A:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
5
PsiBlast_PDB
68.48
24%
-90
- C4 -
3ID7
3
?
A:
[48-366]
-----------------------------------------------------------------
L
H
T
D
L
A
R
L
R
S
G
G
V
G
A
Q
Y
W
S
V
Y
V
R
S
D
L
-
P
-------------------------
G
A
V
----
T
A
T
L
E
Q
I
D
C
V
R
R
L
I
D
R
H
P
G
E
L
R
A
A
L
T
A
A
D
M
-
E
A
A
R
A
-
E
G
-
R
I
A
S
L
M
G
A
E
G
G
H
S
I
D
N
S
L
A
T
L
R
A
L
Y
A
L
G
V
R
Y
M
T
L
T
------
H
N
D
N
N
A
W
A
D
S
A
T
------
D
--------
E
P
G
V
G
------
G
L
S
A
F
G
R
E
V
V
R
E
M
N
R
E
G
M
L
V
D
L
S
H
V
A
A
T
T
M
R
D
A
L
D
T
S
T
A
P
V
-
I
F
S
H
S
S
S
R
A
V
C
D
H
P
R
N
I
P
D
D
V
L
E
R
L
S
A
N
G
G
M
A
M
V
T
F
V
P
K
F
V
L
Q
A
---------------------------------------
A
V
D
W
T
A
E
A
D
D
N
M
R
A
H
GFHHLDSS
P
E
A
M
K
V
H
A
A
F
E
E
R
V
P
R
P
-----------------
V
A
T
V
S
T
V
A
D
H
L
D
H
M
R
E
V
A
G
V
D
H
L
G
I
G
G
D
Y
D
G
T
P
F
T
P
D
G
L
G
D
V
S
G
Y
P
N
L
I
A
E
L
L
D
-
R
G
-
W
S
Q
S
D
L
A
K
L
T
W
K
N
A
V
R
V
L
-----------------------------------
23
HHSearch
67.35
20%
-90
- C4 -
2RAG
3
?
A:
[47-407]
-------------
F
L
T
L
D
T
H
L
D
T
P
A
H
F
G
R
P
---------
G
----
W
------
D
I
A
D
H
H
E
V
E
--
H
D
F
S
Q
V
D
L
P
R
M
N
Q
G
G
L
D
G
G
F
F
V
V
Y
I
G
Q
G
E
L
T
E
K
G
Y
--------------------
T
Y
A
R
----
D
Y
A
L
H
R
T
I
E
I
R
E
M
L
A
A
N
P
D
T
F
E
M
A
L
T
S
D
D
A
-
R
R
I
-
A
K
A
G
-
K
K
F
A
F
V
S
M
E
N
S
W
P
V
G
E
D
L
S
L
V
E
T
F
Y
K
E
G
L
R
M
A
G
P
V
------
H
F
R
N
N
Q
L
A
D
S
S
T
------
D
PKG-----
K
I
W
-
N
------
G
Y
S
P
L
G
L
R
W
L
A
E
A
N
R
L
G
I
V
I
D
V
S
H
A
S
D
D
V
V
D
Q
S
V
A
L
S
K
A
-
P
I
I
A
S
H
S
G
P
K
A
V
Y
D
H
P
R
N
L
D
D
A
R
L
K
K
I
A
D
A
G
G
A
I
C
I
N
S
I
--
Y
L
T
D
T
---------------------------------------
T
PSPEAPDMKTAT
P
E
A
V
K
A
Y
A
D
K
R
A
A
I
D
K
A
HPAA-----------------------
R
G
D
F
D
L
Y
M
K
S
M
L
H
V
L
K
V
A
G
P
K
G
V
C
V
G
A
D
W
D
G
G
G
G
-
M
D
G
F
E
D
I
T
D
L
P
K
I
T
-
A
R
L
K
A
E
G
-
Y
S
D
A
D
I
E
A
I
W
S
G
N
V
L
R
I
V
D
A
---------------------------------
27
HHSearch
65.97
25%
-83
- C4 -
3LY0
3
?
A:
[7-353]
-------------
I
P
V
F
D
G
H
N
D
F
L
L
R
L
L
R
N
------
P
A
N
R
----
E
------
T
I
---
W
LK
G
--
D
G
T
G
H
L
D
L
P
R
M
K
E
G
G
F
A
G
G
F
F
A
I
Y
V
P
S
P
Q
A
H
D
A
A
H
F
E
A
M
M
D
A
PP
F
E
L
P
L
P
P
MIR
A
E
Q
A
Q
----
P
V
A
L
A
M
A
G
H
L
L
W
M
E
R
A
A
R
G
R
F
K
V
C
R
T
A
A
E
V
-
R
S
C
-
H
A
D
G
-
I
V
S
G
I
M
H
M
E
G
A
E
A
I
G
A
D
L
D
A
L
H
L
F
H
S
L
G
L
R
S
L
G
P
V
------
W
S
R
P
T
V
F
G
H
G
V
P
------
F
RFPGSP--
D
T
G
-
E
------
G
L
T
E
A
G
R
R
L
V
A
E
C
N
R
L
K
I
M
L
D
L
S
H
L
N
E
K
G
F
D
D
V
A
R
L
S
D
A
-
P
L
V
A
T
H
S
N
A
H
A
V
T
P
S
T
R
N
L
T
D
R
Q
L
A
M
I
R
E
S
R
G
M
V
G
L
N
F
A
T
S
F
L
R
E
D
---------------------------------------
G
RRSA----------------------------------------------------
E
M
G
W
E
P
V
L
R
H
L
D
H
L
I
D
R
L
G
E
D
H
V
G
M
G
S
D
F
D
G
A
T
I
-
P
Q
G
I
A
D
V
T
G
L
P
A
L
Q
-
A
A
M
R
A
H
G
-
Y
D
E
P
L
M
R
K
L
C
H
E
N
W
Y
G
L
L
E
R
---------------------------------
3
PsiBlast_PDB
64.84
28%
-80
- C4 -
1ITQ
4
DPEP1_HUMAN
A:
[63-331]
--------------------------------------------------------------------------------
Q
F
W
S
V
Y
T
P
C
D
T
-
Q
N
-----------------------
K
D
A
V
----
R
R
T
L
E
Q
M
D
V
V
H
R
M
C
R
M
Y
P
E
T
F
L
Y
V
T
S
S
A
G
I
R
Q
A
F
-
R
-
E
G
-
K
V
A
S
L
I
G
V
E
G
G
H
S
I
D
S
S
L
G
V
L
R
A
L
Y
Q
L
G
M
R
Y
L
T
L
T
HSCNTP
W
A
D
N
W
L
V
D
T
G
D
S
------
E
--------
P
Q
S
-
Q
------
G
L
S
P
F
G
Q
R
V
V
K
E
L
N
R
L
G
V
L
I
D
L
A
H
V
S
V
A
T
M
K
A
T
L
Q
L
S
R
A
P
V
-
I
F
S
H
S
S
A
Y
S
V
C
A
S
R
R
N
V
P
D
D
V
L
R
L
V
K
Q
T
D
S
L
V
M
V
N
F
Y
N
N
Y
I
S
C
T
---------------------------------------
N
--------------------------------------------------------
K
A
N
L
S
Q
V
A
D
H
L
D
H
I
K
E
V
A
G
A
R
A
V
G
F
G
G
D
F
D
G
V
P
R
V
P
E
G
L
E
D
V
S
K
Y
P
D
L
I
A
E
L
L
R
-
R
N
-
W
T
E
A
E
V
K
G
A
L
A
D
N
L
L
--------------------------------------
24
HHSearch
64.83
20%
-90
* C4 *
3B40
4
?
A:
[22-406]
-------------
I
L
S
F
D
S
R
I
T
V
P
L
D
F
G
T
T
---------
G
----
N
------
E
V
---
D
--
K
--
D
G
P
G
Q
L
D
L
V
K
A
G
R
G
R
L
S
G
A
A
L
A
I
F
G
W
P
E
M
W--PHKPT------------------
P
G
F
V
D
E
A
R
H
Q
Q
E
I
R
Y
K
I
L
T
G
M
V
R
D
F
P
N
Q
V
G
I
A
Y
S
P
E
D
F
-
R
R
L
-
A
M
E
G
-
K
F
A
I
V
M
S
M
L
N
A
Y
P
L
G
D
D
L
S
Q
L
D
K
W
A
A
R
G
V
R
M
F
G
F
S
------
Y
V
G
N
N
D
W
A
D
S
S
R
------
P
LPFFNDSP
D
A
L
-
G
------
G
L
S
P
L
G
K
Q
A
V
E
R
L
N
D
L
G
V
I
I
D
V
S
Q
M
S
T
K
A
L
E
Q
V
A
A
L
S
R
A
-
P
I
V
A
S
H
S
A
P
R
A
L
V
D
I
K
R
N
L
S
D
H
E
M
Q
L
I
K
D
S
G
G
V
I
Q
V
V
G
F
P
A
Y
L
R
P
L
---------------------------------------
S
K
P
T
L
D
K
L
D
A
L
R
A
R
F
DLPPLEGLDYALMPGDPIITIWP
E
Q
R
F
G
E
Y
A
S
A
L
Y
G
I
L
E
E
EP
K
A
G
L
K
E
L
V
D
A
I
D
Y
T
V
K
K
V
G
I
D
H
V
G
I
S
S
D
F
N
D
G
G
G
-
V
D
G
W
K
D
V
S
E
I
R
N
V
T
-
A
E
L
I
T
R
G
-
Y
S
D
A
D
I
A
K
L
W
G
G
N
F
L
R
A
W
G
E
---------------------------------
4
PsiBlast_PDB
63.82
28%
-81
- C4 -
1ITU
5
DPEP1_HUMAN
A:
[63-331]
--------------------------------------------------------------------------------
Q
F
W
S
V
Y
T
P
C
D
T
-
Q
N
-----------------------
K
D
A
V
----
R
R
T
L
E
Q
M
D
V
V
H
R
M
C
R
M
Y
P
E
T
F
L
Y
V
T
S
S
A
G
I
R
Q
A
F
-
R
-
E
G
-
K
V
A
S
L
I
G
V
E
G
G
H
S
I
D
S
S
L
G
V
L
R
A
L
Y
Q
L
G
M
R
Y
L
T
L
T
HSCNTP
W
A
D
N
W
L
V
D
T
G
D
S
------
E
--------
P
Q
S
-
Q
------
G
L
S
P
F
G
Q
R
V
V
K
E
L
N
R
L
G
V
L
I
D
L
A
H
V
S
V
A
T
M
K
A
T
L
Q
L
S
R
A
P
V
-
I
F
S
H
S
S
A
Y
S
V
C
A
S
R
R
N
V
P
D
D
V
L
R
L
V
K
Q
T
D
S
L
V
M
V
N
F
Y
N
N
Y
I
S
C
T
---------------------------------------
N
--------------------------------------------------------
K
A
N
L
S
Q
V
A
D
H
L
D
H
I
K
E
V
A
G
A
R
A
V
G
F
G
G
D
F
D
G
V
P
R
V
P
E
G
L
E
D
V
S
K
Y
P
D
L
I
A
E
L
L
R
-
R
N
-
W
T
E
A
E
V
K
G
A
L
A
D
N
L
L
--------------------------------------