@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2471: (2016-04-04 )
MSKLFSEYKLKDVTLKNRIVMSPMCMYSVENKDGIATDFHFAHYVSRAAGGTGLVILEATAVQEVGRISEFDLGLWNDEQVPALKKLVGGLHYHGAKAGIQLAHAGRKAVLPGEIVAPSAIAFDEKSDKPVELTKEAIKEVVADFKRAAYRAKEAGFDVIEIHAAHGYLIHQFLSPITNRREDNYGGPAGNRYKILSDIIKAVKEVWDGPIIVRVSATDYAHGGLQLEDHIPFAKWMKADGVELIDVSTGGLVNVAPPVFPGYQVPFADEIRRGAGIATGALGLITRGEQAEEILCNERADLIIVGRELLRNPYFAKDAAKQLGETIEAPKQYSRAWK
Atome Classification :
(44 SA)
.........10........20........30........40.........50........60........70..-......80........90........100.....---..----------110--.----------.-.-----....120---.---------------......---------------.----------.130--------------------...----....140..-.....150.......160.......170.......180.......190.......200.-...--.--..-210.......220.......230.......240.......250.-....-..260.......270.......280.......290.......300.......310.......320.......330......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
K
L
F
S
E
YKLK
D
V
T
LKN
R
I
V
MSP
M
C
M
Y
S
VENKDGIA
T
D
F
H
-
F
A
H
Y
V
S
R
AAGG
T
G
L
V
I
L
E
A
T
A
V
Q
E
V
GRISEFDL-GLWND
E
Q
V
P
A
L
K
K
L
V
G
GLHYHGAKA
G
I
Q
L
AHAGR---KA----------VLP--G----------E-I-----VAP
S
A
-----
I
---------------AFDEKS---------------D----------K
P
V
E
--------------------
L
T
K
----
E
A
I
K
E
V
V
A
D
-
F
K
R
A
A
Y
R
A
K
EAGF
D
V
I
E
I
HAA
H
G
Y
L
I
H
Q
F
L
S
P
I
TNRREDNYGGPAG
N
R
Y
K
I
L
S
D
I
I
K
A
V
-
K
E
V--W--DG-
P
I
I
V
R
V
SATDYAHG
G
L
Q
LEDHI
P
F
A
K
W
MKADG
V
E
L
I
D
VSTG
G
L
V
-NVAP-PVFPGYQVP
F
A
D
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I
R
RGAGIATG
A
L
G
LITRG
E
Q
A
E
E
I
L
C
NERA
D
L
I
I
V
G
R
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L
LRNPYF
A
K
D
A
A
K
Q
L
G
E
T
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A
P
K
Q
Y
SRAWK
111
HHSearch
98.25
62%
-103
- C4 -
1Z41
5
NAMA_BACSU
A:
[2-338]
A
R
K
L
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N
R
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K
L
T
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M
A
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L
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A
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---------------
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---------------
A
----------
T
P
V
E
--------------------
M
S
A
----
E
K
V
K
E
T
V
Q
E
-
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G
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R
Y
R
F
L
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I
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D
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V
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K
Q
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--
W
---
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A
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D
Y
T
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L
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K
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A
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Q
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N
T
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P
A
P
V
Q
Y
E
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G
W
-
3
PsiBlast_PDB
98.12
61%
-103
- C4 -
1Z41
5
NAMA_BACSU
A:
[4-338]
--
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
S
H
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K
D
G
K
L
T
P
F
H
-
M
A
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G
L
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A
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A
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N
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Q
G
R
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Q
D
L
-
G
I
W
S
D
E
H
I
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G
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A
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L
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Q
V
K
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G
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K
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L
A
H
A
G
R
---
K
A
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L
E
--
G
----------
D
-
I
-----
F
A
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A
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---------------
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Q
S
---------------
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----------
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P
V
E
--------------------
M
S
A
----
E
K
V
K
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Q
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K
Q
A
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A
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N
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R
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Y
G
G
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R
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R
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I
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V
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A
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D
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T
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K
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L
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A
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W
M
K
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Q
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V
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A
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V
-
H
A
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N
V
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P
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Y
Q
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A
A
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Q
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N
T
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P
A
P
V
Q
Y
E
R
G
W
-
5
PsiBlast_PDB
98.08
61%
-104
- C4 -
1Z44
7
NAMA_BACSU
A:
[4-338]
--
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
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S
H
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K
L
T
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F
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M
A
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A
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A
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N
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Q
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Q
D
L
-
G
I
W
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A
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---
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A
----------
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L
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--
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----------
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-----
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A
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S
A
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---------------
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---------------
A
----------
T
P
V
E
--------------------
M
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A
----
E
K
V
K
E
T
V
Q
E
-
F
K
Q
A
A
A
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A
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G
F
D
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I
H
A
A
H
G
Y
L
I
H
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F
L
S
P
L
S
N
H
R
T
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
R
E
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I
D
E
V
-
K
Q
V
--
W
--
D
G
-
P
L
F
V
R
V
S
A
S
D
Y
T
D
K
G
L
D
I
A
D
H
I
G
F
A
K
W
M
K
E
Q
G
V
D
L
I
D
C
S
S
G
A
L
V
-
H
A
D
I
-
N
V
F
P
G
Y
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F
A
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A
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Q
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N
T
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P
A
P
V
Q
Y
E
R
G
W
-
4
PsiBlast_PDB
97.74
61%
-103
- C4 -
1Z42
5
NAMA_BACSU
A:
[4-338]
--
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
S
H
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K
D
G
K
L
T
P
F
H
-
M
A
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Y
I
S
R
A
I
G
Q
V
G
L
I
I
V
E
A
S
A
V
N
P
Q
G
R
I
T
D
Q
D
L
-
G
I
W
S
D
E
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I
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G
F
A
K
L
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Q
V
K
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Q
G
S
K
I
G
I
Q
L
A
H
A
G
R
---
K
A
----------
E
L
E
--
G
----------
D
-
I
-----
F
A
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S
A
-----
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---------------
A
F
D
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Q
S
---------------
A
----------
T
P
V
E
--------------------
M
S
A
----
E
K
V
K
E
T
V
Q
E
-
F
K
Q
A
A
A
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A
K
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G
F
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I
H
A
A
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L
I
H
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L
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N
H
R
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D
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Y
G
G
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R
Y
R
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L
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I
D
E
V
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K
Q
V
--
W
--
D
G
-
P
L
F
V
R
V
S
A
S
D
Y
T
D
K
G
L
D
I
A
D
H
I
G
F
A
K
W
M
K
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Q
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V
D
L
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D
C
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G
A
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V
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H
A
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N
V
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P
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G
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N
T
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P
A
P
V
Q
Y
E
R
G
W
-
6
PsiBlast_PDB
97.43
61%
-104
- C4 -
1Z48
2
NAMA_BACSU
A:
[4-338]
--
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
S
H
E
K
D
G
K
L
T
P
F
H
-
M
A
H
Y
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R
A
I
G
Q
V
G
L
I
I
V
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A
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A
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Q
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R
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D
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L
-
G
I
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A
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A
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---
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A
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L
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----------
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---------------
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----------
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A
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E
K
V
K
E
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F
K
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A
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L
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N
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R
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D
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G
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P
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N
R
Y
R
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L
R
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I
D
E
V
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K
Q
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--
W
--
D
G
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P
L
F
V
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V
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A
S
D
Y
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K
G
L
D
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I
G
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A
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W
M
K
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A
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H
A
D
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Q
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N
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P
A
P
V
Q
Y
E
R
G
W
-
2
PsiBlast_PDB
95.25
59%
-98
- C4 -
3GR8
4
NAMA_GEOKA
A:
[3-339]
-
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
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T
W
H
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K
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R
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D
L
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G
I
W
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V
G
L
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A
A
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Q
L
A
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Y
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L
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R
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G
G
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Y
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G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
A
P
V
Q
Y
E
R
G
W
R
22
PsiBlast_CBE
95.13
59%
-101
- C4 -
3GR7
3
NAMA_GEOKA
B:
[3-339]
-
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
-
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
-
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
---
K
S
----------
Q
V
P
--
G
----------
E
-
I
-----
I
A
P
S
A
-----
V
---------------
P
F
D
D
S
S
---------------
P
----------
T
P
K
E
--------------------
M
T
K
----
A
D
I
E
E
T
V
Q
A
-
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
-
R
E
V
--
W
--
D
G
-
P
L
F
V
R
I
S
A
S
D
Y
H
P
D
G
L
T
A
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
A
I
V
-
P
A
R
M
-
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
A
P
V
Q
Y
E
R
G
W
R
1
PsiBlast_PDB
94.95
59%
-100
- C4 -
3GR7
3
NAMA_GEOKA
A:
[3-339]
-
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
-
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
-
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
---
K
S
----------
Q
V
P
--
G
----------
E
-
I
-----
I
A
P
S
A
-----
V
---------------
P
F
D
D
S
S
---------------
P
----------
T
P
K
E
--------------------
M
T
K
----
A
D
I
E
E
T
V
Q
A
-
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
-
R
E
V
--
W
--
D
G
-
P
L
F
V
R
I
S
A
S
D
Y
H
P
D
G
L
T
A
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
A
I
V
-
P
A
R
M
-
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
A
P
V
Q
Y
E
R
G
W
R
112
HHSearch
94.91
59%
-102
- C4 -
3GR7
3
NAMA_GEOKA
A:
[2-338]
N
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
-
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
-
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
---
K
S
----------
Q
V
P
--
G
----------
E
-
I
-----
I
A
P
S
A
-----
V
---------------
P
F
D
D
S
S
---------------
P
----------
T
P
K
E
--------------------
M
T
K
----
A
D
I
E
E
T
V
Q
A
-
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
-
R
E
V
--
W
---
D
G
P
L
F
V
R
I
S
A
S
D
Y
H
P
D
G
L
T
A
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
A
I
V
-
P
A
R
M
-
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
A
P
V
Q
Y
E
R
G
W
-
21
PsiBlast_CBE
94.84
59%
-98
- C4 -
3GR8
3
NAMA_GEOKA
B:
[3-339]
-
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
-
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
-
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
---
K
S
----------
Q
V
P
--
G
----------
E
-
I
-----
I
A
P
S
A
-----
V
---------------
P
F
D
D
S
S
---------------
P
----------
T
P
K
E
--------------------
M
T
K
----
A
D
I
E
E
T
V
Q
A
-
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
-
R
E
V
--
W
--
D
G
-
P
L
F
V
R
I
S
A
S
D
Y
H
P
D
G
L
T
A
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
A
I
V
-
P
A
R
M
-
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
A
P
V
Q
Y
E
R
G
W
R
25
PsiBlast_CBE
91.06
51%
-103
- C4 -
3KRZ
2
?
B:
[3-336]
--
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
----------
E
D
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
PE
N
K
-
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
---
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
K
28
PsiBlast_CBE
90.92
51%
-100
- C4 -
3KRU
3
?
B:
[2-336]
-
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
----------
E
D
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
PE
N
K
-
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
---
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
K
24
PsiBlast_CBE
90.89
51%
-102
- C4 -
3KRZ
3
?
C:
[3-336]
--
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
----------
E
D
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
PE
N
K
-
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
---
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
K
26
PsiBlast_CBE
90.54
51%
-102
- C4 -
3KRU
3
?
D:
[2-336]
-
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
----------
E
D
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
PE
N
K
-
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
---
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
K
7
PsiBlast_PDB
90.16
51%
-99
- C4 -
3KRU
3
?
A:
[2-336]
-
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
----------
E
D
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
PE
N
K
-
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
---
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
K
114
HHSearch
90.04
52%
-100
- C4 -
3KRU
2
?
A:
[2-327]
-
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
S
-
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
E---------
D
-
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
P-
E
N
K
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
V
L
H
T
Y
T
S
K
E
D
W
------------
27
PsiBlast_CBE
89.87
51%
-102
- C4 -
3KRU
3
?
C:
[2-335]
-
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
----------
E
D
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
PE
N
K
-
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
---
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
-
8
PsiBlast_PDB
89.82
51%
-101
- C4 -
3KRZ
3
?
A:
[2-336]
-
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
-
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
-
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
----------
N
I
S
--
Y
----------
E
D
V
-----
V
G
P
S
P
-----
I
---------------
K
A
G
D
R
Y
---------------
K
----------
L
P
R
E
--------------------
L
S
V
----
E
E
I
K
S
I
V
K
A
-
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
-
R
K
N
--
W
PE
N
K
-
P
I
F
V
R
V
S
A
D
D
Y
M
E
G
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
-
N
V
D
I
-
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
---
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
K
113
HHSearch
88.10
49%
-97
- C4 -
3HGJ
4
?
A:
[2-349]
-
A
L
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
T
-
L
E
G
E
V
T
D
W
H
-
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
-
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
---
K
A
----------
G
T
A
--
R
PWEGGKPLGW
R
-
V
-----
V
G
P
S
P
-----
I
---------------
P
F
D
E
G
Y
---------------
P
----------
V
P
E
P
--------------------
L
D
E
----
A
G
M
E
R
I
L
Q
A
-
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
-
R
E
V
--
V
P-
R
E
L
P
L
F
V
R
V
S
A
T
D
W
G
E
G
G
W
S
L
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
G
V
V
-
L
R
V
R
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
G
V
A
P
E
V
P
P
Q
Y
Q
R
G
F
-
30
PsiBlast_CBE
87.06
48%
-95
- C4 -
3HGJ
2
?
C:
[2-349]
-
A
L
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
-
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
-
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
---
K
A
GTARPWEGGK
P
L
G
--
W
----------
R
-
V
-----
V
G
P
S
P
-----
I
---------------
P
F
D
E
G
Y
---------------
P
----------
V
P
E
P
--------------------
L
D
E
----
A
G
M
E
R
I
L
Q
A
-
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
-
R
E
V
VP
R
--
E
L
-
P
L
F
V
R
V
S
A
T
D
W
G
E
G
G
W
S
L
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
G
V
V
L
R
V
R
I
-
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
G
V
A
P
E
V
P
P
Q
Y
Q
R
G
F
-
68
PsiBlast_CBE
51.72
35%
-79
- C4 -
4JIC
2
?
A:
[2-232]
-
T
S
L
F
E
P
A
Q
A
G
D
I
A
L
A
N
R
I
V
M
A
P
L
T
R
N
--
R
S
P
G
A
I
P
N
N
L
N
-
A
T
Y
Y
E
Q
R
A
T
--
A
G
L
I
V
T
E
G
T
P
I
S
Q
Q
G
Q
G
Y
A
D
V
P
-
G
L
Y
K
R
E
A
I
E
G
W
K
K
I
T
D
G
V
H
S
A
G
G
K
I
V
A
Q
I
W
H
V
G
R
ISH
T
S
----------
L
Q
P
HG
G
----------
Q
-
P
-----
V
A
P
S
A
-----
I
TAK
S
K
T
Y
I
I
NDD
G
T
G
A
F
A
E
T
S
---------------
E
-----------
P
R
A
--------------------
L
T
I
----
D
D
I
G
L
I
L
E
D
-
Y
R
S
G
A
R
A
A
L
E
A
G
F
D
G
V
E
I
H
A
A
N
G
Y
L
I
E
Q
F
L
K
S
S
T
N
Q
R
T
D
D
Y
G
G
S
I
E
N
R
A
R
F
L
L
E
V
V
D
A
V
A
E
E
I
--
G
--
A
G
-
R
T
G
I
R
L
S
----------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
50.75
35%
-77
- C4 -
4JIC
1
?
B:
[2-232]
-
T
S
L
F
E
P
A
Q
A
G
D
I
A
L
A
N
R
I
V
M
A
P
L
T
R
N
--
R
S
P
G
A
I
P
N
N
L
N
-
A
T
Y
Y
E
Q
R
A
T
--
A
G
L
I
V
T
E
G
T
P
I
S
Q
Q
G
Q
G
Y
A
D
V
P
-
G
L
Y
K
R
E
A
I
E
G
W
K
K
I
T
D
G
V
H
S
A
G
G
K
I
V
A
Q
I
W
H
V
G
R
ISH
T
S
----------
L
Q
P
HG
G
----------
Q
-
P
-----
V
A
P
S
A
-----
I
TAKSKTYIINDDGTG
A
F
A
E
T
S
---------------
E
-----------
P
R
A
--------------------
L
T
I
----
D
D
I
G
L
I
L
E
D
-
Y
R
S
G
A
R
A
A
L
E
A
G
F
D
G
V
E
I
H
A
A
N
G
Y
L
I
E
Q
F
L
K
S
S
T
N
Q
R
T
D
D
Y
G
G
S
I
E
N
R
A
R
F
L
L
E
V
V
D
A
V
A
E
E
I
--
G
--
A
G
-
R
T
G
I
R
L
S
----------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
50.70
32%
-80
- C4 -
3TJL
6
?
A:
[12-231]
-
S
E
A
F
Q
S
I
K
V
G
N
N
T
L
Q
T
K
I
V
Y
P
P
T
T
R
F
R
A
L
-
E
D
H
T
P
S
D
L
Q
-
L
Q
Y
Y
G
D
R
S
T
F
P
G
T
L
L
I
T
E
A
T
F
V
S
P
Q
A
S
G
Y
E
G
A
A
P
G
I
W
T
D
K
H
A
K
A
W
K
V
I
T
D
K
V
H
A
N
G
S
F
V
S
T
Q
L
I
F
L
G
R
VAD
P
A
----------
V
M
K
--
T
----------
R
-
G
-----
L
N
P
V
S
-----
A
---------------
S
A
T
Y
E
S
---------------
D
A
A
K
E
A
A
E
A
V
G
N
P
V
R
A
-------------------
L
T
T
----
Q
E
V
K
D
L
V
Y
E
A
Y
T
N
A
A
Q
K
A
M
D
A
G
F
D
Y
I
E
L
H
A
A
H
G
Y
L
L
D
Q
F
L
Q
P
C
T
N
Q
R
T
D
E
Y
G
G
S
I
E
N
R
A
R
L
I
L
E
L
I
D
H
L
-
S
T
I
-------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
50.70
32%
-80
- C4 -
4M5P
4
?
A:
[12-231]
-
S
E
A
F
Q
S
I
K
V
G
N
N
T
L
Q
T
K
I
V
Y
P
P
T
T
R
F
R
A
L
-
E
D
H
T
P
S
D
L
Q
-
L
Q
Y
Y
G
D
R
S
T
F
P
G
T
L
L
I
T
E
A
T
F
V
S
P
Q
A
S
G
W
E
G
A
A
P
G
I
W
T
D
K
H
A
K
A
W
K
V
I
T
D
K
V
H
A
N
G
S
F
V
S
T
Q
L
C
F
L
G
R
VAD
P
A
----------
V
M
K
--
T
----------
R
-
G
-----
L
N
P
V
S
-----
A
---------------
S
A
T
Y
E
S
---------------
D
A
A
K
E
A
A
E
A
V
G
N
P
V
R
A
-------------------
L
T
T
----
Q
E
V
K
D
L
V
Y
E
A
Y
T
N
A
A
Q
K
A
M
D
A
G
F
D
Y
I
E
L
H
A
A
H
G
Y
L
L
D
Q
F
L
Q
P
C
T
N
Q
R
T
D
E
Y
G
G
S
I
E
N
R
A
R
L
I
L
E
L
I
D
H
L
-
S
T
I
-------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
49.50
32%
-78
- C4 -
3UPW
6
?
A:
[12-231]
-
S
E
A
F
Q
S
I
K
V
G
N
N
T
L
Q
T
K
I
V
Y
P
P
T
T
R
F
R
A
L
-
E
D
H
T
P
S
D
L
Q
-
L
Q
Y
Y
G
D
R
S
T
F
P
G
T
L
L
I
T
E
A
T
F
V
S
P
Q
A
S
G
Y
E
G
A
A
P
G
I
W
T
D
K
H
A
K
A
W
K
V
I
T
D
K
V
H
A
N
G
S
F
V
S
T
Q
L
I
F
L
G
R
VAD
P
A
----------
V
M
K
--
T
----------
R
-
G
-----
L
N
P
V
S
-----
A
---------------
S
A
T
Y
E
S
---------------
D
A
A
K
E
A
A
E
A
V
G
N
P
V
R
A
-------------------
L
T
T
----
Q
E
V
K
D
L
V
Y
E
A
Y
T
N
A
A
Q
K
A
M
D
A
G
F
D
Y
I
E
L
H
A
A
H
G
Y
L
L
D
Q
F
L
Q
P
C
T
N
Q
R
T
D
E
Y
G
G
S
I
E
N
R
A
R
L
I
L
E
L
I
D
H
L
-
S
T
I
-------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
49.25
32%
-81
- C4 -
4DF2
4
?
A:
[12-231]
-
S
E
A
F
Q
S
I
K
V
G
N
N
T
L
Q
T
K
I
V
Y
P
P
T
T
R
F
R
A
L
-
E
D
H
T
P
S
D
L
Q
-
L
Q
Y
Y
G
D
R
S
T
F
P
G
T
L
L
I
T
E
A
T
F
V
S
P
Q
A
S
G
Y
E
G
A
A
P
G
I
W
T
D
K
H
A
K
A
W
K
V
I
T
D
K
V
H
A
N
G
S
F
V
S
T
Q
L
I
F
L
G
R
VAD
P
A
----------
V
M
K
--
T
----------
R
-
G
-----
L
N
P
V
S
-----
A
---------------
S
A
T
Y
E
S
---------------
D
A
A
K
E
A
A
E
A
V
G
N
P
V
R
A
-------------------
L
T
T
----
Q
E
V
K
D
L
V
Y
E
T
Y
T
N
A
A
Q
K
A
M
D
A
G
F
D
Y
I
E
L
H
A
A
H
G
Y
L
L
D
Q
F
L
Q
P
C
T
N
Q
R
T
D
E
Y
G
G
S
I
E
N
R
A
R
L
I
L
E
L
I
D
H
L
-
S
T
I
-------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
48.26
32%
-76
- C4 -
1ICP
4
OPR1_SOLLC
A:
[16-251]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
A
H
F
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
48.02
32%
-76
- C4 -
3HGR
2
OPR1_SOLLC
A:
[16-255]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
A
H
F
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
47.98
32%
-74
- C4 -
1ICQ
2
OPR1_SOLLC
B:
[16-256]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
A
H
F
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
47.48
32%
-73
- C4 -
1ICS
1
OPR1_SOLLC
A:
[16-255]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
A
H
F
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
47.39
32%
-75
- C4 -
1ICP
4
OPR1_SOLLC
B:
[16-252]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
A
H
F
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
46.96
32%
-74
- C4 -
1ICS
1
OPR1_SOLLC
B:
[16-255]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
LTPQIMSNGIDIAHF
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
46.57
32%
-73
- C4 -
3HGR
2
OPR1_SOLLC
B:
[16-255]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
A
H
F
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
46.38
32%
-72
- C4 -
1ICQ
2
OPR1_SOLLC
A:
[16-255]
---
L
M
S
P
C
K
M
G
K
F
E
L
C
H
R
V
V
L
A
P
L
---
T
R
Q
R
S
Y
G
Y
I
P
Q
P
H
A
I
L
H
Y
S
Q
R
S
T
N
G
-
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
-
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
---
V
S
----------
N
K
D
--
F
----------
Q
-
P
-----
N
G
E
D
P
-----
I
---------------
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
A
H
F
T
----------
R
P
R
R
--------------------
L
T
T
----
D
E
I
P
Q
I
V
N
E
-
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
--
G
--
S
D
-
R
V
G
I
R
I
S
P
--
F
A
H
----------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
44.80
34%
-77
- C4 -
2HS8
1
OPR3_SOLLC
B:
[17-242]
--
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NR
W
R
I
L
M
PDG
T
H
G
I
Y
P
K
P
R
A
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
44.28
32%
-77
- C4 -
4QNW
6
OYE3_ASPFU
A:
[8-215]
-
A
Q
L
F
K
P
L
K
V
G
R
C
H
L
Q
H
R
M
I
M
A
P
T
T
R
F
R
A
D
G
Q
-
G
V
P
L
P
F
V
-
Q
E
Y
Y
G
Q
R
A
S
V
P
G
T
L
L
I
T
E
A
T
D
I
T
P
K
A
M
G
Y
K
H
V
P
-
G
I
W
S
E
P
Q
R
E
A
W
R
E
I
V
S
R
V
H
S
K
K
C
F
I
F
C
Q
L
W
A
T
G
R
---
A
A
DPD-------
V
L
A
--
D
MK--------
D
-
L
-----
I
S
S
S
A
-----
V
---------------
P
V
E
E
K
G
---------------
P
----------
L
P
R
A
--------------------
L
T
E
----
D
E
I
Q
Q
C
I
A
D
-
F
A
Q
A
A
R
N
A
I
N
A
G
F
D
G
V
E
I
H
G
A
N
G
Y
L
I
D
Q
F
T
Q
K
S
C
N
H
R
Q
D
R
W
G
G
S
I
E
N
R
A
R
F
A
V
E
V
T
R
A
V
-
I
E
--------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
44.10
33%
-77
- C4 -
4A3U
5
?
A:
[2-212]
-
P
S
L
F
D
P
I
R
F
G
A
F
T
A
K
N
R
I
W
M
A
P
L
T
R
-
G
R
A
T
R
D
H
V
P
T
E
I
M
-
A
E
Y
Y
A
Q
R
A
S
A
G
--
L
I
I
S
E
A
T
G
I
S
Q
E
G
L
G
W
P
Y
A
P
-
G
I
W
S
D
A
Q
V
E
A
W
L
P
I
T
Q
A
V
H
D
A
G
G
L
I
F
A
Q
L
W
H
M
G
R
---------------
M
V
P
--
S
----------
N
-
V
SG
M
Q
P
V
A
P
S
A
S
Q
A
P
G
L
---------------
G
H
T
Y
D
G
---------------
K
----------
K
P
Y
D
--------------------
V
A
R
ALRL
D
E
I
P
R
L
L
D
D
-
Y
E
K
A
A
R
H
A
L
K
A
G
F
D
G
V
Q
I
H
A
A
N
G
Y
L
I
D
E
F
I
R
D
S
T
N
H
R
H
D
E
Y
G
G
A
V
E
N
R
I
R
L
L
K
D
V
T
E
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
43.95
34%
-78
- C4 -
2HS8
1
OPR3_SOLLC
A:
[16-242]
-
N
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NR
W
R
I
L
M
PDG
T
H
G
I
Y
P
K
P
R
A
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
42.51
34%
-75
- C4 -
2HSA
2
OPR3_SOLLC
A:
[16-231]
-
N
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NR
W
R
I
L
M
PDG
T
H
G
I
Y
P
K
P
R
A
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
42.36
34%
-73
- C4 -
2HSA
1
OPR3_SOLLC
B:
[17-231]
--
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NR
W
R
I
L
M
PDG
T
H
G
I
Y
P
KPRA
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
42.24
34%
-75
- C4 -
3HGS
2
OPR3_SOLLC
B:
[16-245]
-
N
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NR
W
R
I
L
M
PDG
T
H
G
I
Y
P
K
P
R
A
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
41.28
34%
-77
- C4 -
2HS6
2
OPR3_SOLLC
B:
[16-245]
-
N
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NRWRILMPDGTHGIYPKPRA
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
40.35
34%
-75
- C4 -
2HS6
2
OPR3_SOLLC
A:
[16-245]
-
N
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NR
W
R
I
L
M
PDG
T
H
G
I
Y
P
K
P
R
A
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
40.03
34%
-75
- C4 -
3HGS
2
OPR3_SOLLC
A:
[16-239]
-
N
P
L
F
S
P
Y
K
M
G
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
C
R
A
L
N
N
--
I
P
Q
A
A
L
-
G
E
Y
Y
E
Q
R
A
T
A
G
-
G
F
L
I
T
E
G
T
M
I
S
P
T
S
A
G
F
P
H
V
P
-
G
I
F
T
K
E
Q
V
R
E
W
K
K
I
V
D
V
V
H
A
K
G
A
V
I
F
C
Q
L
W
H
V
G
R
---
A
S
---------------
H
----------
E
-
V
-----
Y
Q
P
A
G
-----
A
---------------
A
P
I
S
S
T
---------------
E
----------
K
P
I
S
NR
W
R
I
L
M
PDG
T
H
G
I
Y
P
K
P
R
A
I
G
T
----
Y
E
I
S
Q
V
V
E
D
-
Y
R
R
S
A
L
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
I
D
Q
F
L
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
A
N
R
C
K
F
I
T
Q
V
V
Q
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------