@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2478: (2016-04-04 )
MASEEKIYDVIIIGAGPAGMTAALYTSRADLDTLMIERGVPGGQMVNTAEVENYPGFDSILGPDLSDKMLSGAKQFGAEYAYGDIKEVVDGKEFKTVTAGSKTYKARAIIIATGAEHRKLGAAGEEELSGRGVSYCAVCDGAFFKNRELIVVGGGDSAVEEGTYLTRYADKVTIVHRRDKLRAQQILQDRAFKDEKVDFIWNSTVEEIVGDGKKVTGAKLVSTVDGSESIMPVDGVFIYVGLVPLTKAFLNLGITDDEGYIVTDEEMRTNLPGIFAAGDVRAKSLRQIVTATGDGGLAGQNAQKYVEELKESLEAEAAK
Atome Classification :
(22 SA)
.........10........20........30-.-......-----.----40----.-----........50......-.-.-60-........70........80..-.....-.90--.-----.--..----...---.100.......110.......120.....----..130--.........140-.--.......150.......160.......170.......180...-....190.......200.....--..210--..--.--.....220.......230.......240.......250------...-.....260..-..-....270.......280.......290.......300....---...310.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASEE
K
I
Y
D
V
I
I
IGAGPAG
M
T
A
A
L
YTSRA
D
L
-
D
-
T
L
M
I
ER-----G----V-----P-----GG
Q
M
V
N
T
A
EVENYPG
F
-
D
-
S
-IL-GPD
L
S
D
K
M
L
S
G
A
K
Q
FGAEYAYG-
D
I
K
E
V-VDG--K-----
E
--
F
K
----
T
V
T---AGSK
T
Y
K
A
R
A
I
I
I
ATGAEHRKLGAA
G
E
E
E----LSG----RG
V
S
Y
C
A
VCDG--A--FFKNR
E
L
I
V
VGGGD
S
A
V
EEG
T
Y
L
T
R
YA
D
K
V
T
I
V
H
R
R
D
K
L
R
A
Q
Q
-
I
L
Q
D
RAFKDE
K
V
D
F
I
W
N
S
T
V
E
E
--
I
VGD---GK--K--VTG
A
K
L
V
S
TVDGSESIMPVD
G
V
F
I
Y
V
G
L
V
P
L
T
K
A
F
L
-N------LGI-TDDE
G
Y
I
-
V
T
-
D
E
-
E
M
RTNLP
G
I
FAAG
D
V
R
A
K
S
L
R
Q
I
V
TATGDGGLAGQ
N
A
Q
K
Y
V
---
E
E
L
K
E
S
L
E
AEAAK
1
PsiBlast_PDB
97.29
64%
-93
- C2 -
4GCM
6
TRXB_STAAW
A:
[7-310]
-------
F
D
I
A
I
I
G
A
G
P
A
G
M
T
A
A
V
Y
A
S
R
A
N
L
-
K
-
T
V
M
I
E
R
-----
G
----
I
-----
P
-----
G
G
Q
M
A
N
T
E
E
V
E
N
F
P
G
F
-
E
-
M
-
I
T
-
G
P
D
L
S
T
K
M
F
E
H
A
K
K
F
G
A
V
Y
Q
Y
G
-
D
I
K
S
V
-
E
D
K
--
G
-----
E
--
Y
K
----
V
I
N
---
F
G
N
K
E
L
T
A
K
A
V
I
I
A
T
G
A
E
Y
K
K
I
G
V
P
G
E
Q
E
----
L
G
G
----
R
G
V
S
Y
C
A
V
C
D
G
--
A
--
F
F
K
N
K
R
L
F
V
I
G
G
G
D
S
A
V
E
E
G
T
F
L
T
K
F
A
D
K
V
T
I
V
H
R
R
D
E
L
R
A
Q
R
-
I
L
Q
D
R
A
F
K
N
D
K
I
D
F
I
W
S
H
T
L
K
S
--
I
N
E
K
---
D
G
--
K
--
V
G
S
V
T
L
T
S
T
K
D
G
S
E
E
T
H
E
A
D
G
V
F
I
Y
I
G
M
K
P
L
T
A
P
F
K
-
D
------
L
G
I
-
T
N
D
V
G
Y
I
-
V
T
-
K
D
-
D
M
T
T
S
V
P
G
I
F
A
A
G
D
V
R
D
K
G
L
R
Q
I
V
T
A
T
G
D
G
S
I
A
A
Q
S
A
A
E
Y
I
---
E
H
L
N
D
--------
3
PsiBlast_PDB
86.01
44%
-88
- C2 -
2A87
5
TRXB_MYCTU
A:
[10-322]
--
A
H
H
P
V
R
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
-
A
-
P
L
V
F
E
G
-----
T
----
S
-----
F
-----
G
G
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
R
N
-
G
-
I
T
-
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
L
R
M
E
-
D
V
E
S
V
S
L
H
G
--
P
-----
L
--
K
S
----
V
V
T
---
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
----
L
L
G
----
R
G
V
S
S
C
A
T
C
D
G
--
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
-
I
M
L
D
R
A
R
N
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
D
G
D
----
T
--
T
--
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
-
E
------
A
I
D
-
V
D
P
D
G
Y
V
L
V
Q
-
G
R
-
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
A
E
H
A
A
T
G
------
4
PsiBlast_PDB
85.56
43%
-95
- C2 -
1VDC
2
TRXB1_ARATH
A:
[11-325]
---------
L
C
I
V
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
-
K
-
P
L
L
F
E
G
-----
W
----
M
ANDIA
P
-----
G
G
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
P
E
-
G
-
I
L
-
G
V
E
L
T
D
K
F
R
K
Q
S
E
R
F
G
T
T
I
F
T
E
-
T
V
T
K
V
D
F
S
S
--
K
-----
P
--
F
K
----
L
F
T
----
D
S
K
A
I
L
A
D
A
V
I
L
A
I
G
A
V
A
K
R
L
S
F
V
G
S
G
E
----
V
L
G
GFWN
R
G
I
S
A
C
A
V
C
D
G
--
A
AP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
M
E
E
A
N
F
L
T
K
Y
G
S
K
V
Y
I
I
H
R
R
D
A
F
R
A
S
K
-
I
M
Q
Q
R
A
L
S
N
P
K
I
D
V
I
W
N
S
S
V
V
E
--
A
Y
G
D
---
G
E
--
R
DV
L
G
G
L
K
V
K
N
V
V
T
G
D
V
S
D
L
K
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
-
F
L
-
D
------
G
G
V
E
L
D
S
D
G
Y
V
-
V
T
-
K
P
G
T
T
Q
T
S
V
P
G
V
F
A
A
G
D
V
Q
D
K
K
Y
R
Q
A
I
T
A
A
G
T
G
C
M
A
A
L
D
A
E
H
Y
L
---
Q
E
I
----------
99
HHSearch
84.50
46%
-86
- C2 -
2A87
5
TRXB_MYCTU
A:
[11-318]
---
H
H
P
V
R
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
-
A
-
P
L
V
F
E
G
-----
T
----
S
-----
F
-----
G
G
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
-
R
N
G
-
I
T
-
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
L
R
M
E
-
D
V
E
S
V
-
S
L
H
--
G
P----
L
--
K
S
----
V
V
T
---
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
----
L
L
G
----
R
G
V
S
S
C
A
T
C
D
G
--
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
-
I
M
L
D
R
A
R
N
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
D
G
D
---
T
---
T
--
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
-
E
------
A
I
D
-
V
D
P
D
G
Y
V
-
L
V
-
Q
G
R
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
A
E
H
----------
95
HHSearch
84.31
38%
-91
- C2 -
3R9U
2
?
A:
[1-313]
---
S
N
A
M
L
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
-
K
N
V
V
M
F
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
T
S
S
S
E
I
E
N
Y
P
G
V
-
A
Q
V
-
M
D
-
G
I
S
F
M
A
P
W
S
E
Q
C
M
R
F
G
L
K
H
E
M
V
-
G
V
E
Q
I
-
L
K
N
SD
G
-----
S
--
F
T
----
I
K
L
---
E
G
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
A
P
K
K
A
G
F
K
G
E
D
E
----
F
F
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
P
-
S
T
V
E
K
V
K
K
N
E
K
I
E
L
I
T
S
A
S
V
D
E
--
V
Y
G
D
---
K
M
--
G
--
V
A
G
V
K
V
K
-
L
K
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
R
N
E
I
L
K
-
Q
DDSKF-
L
C
N
-
M
E
E
G
G
Q
V
-
S
V
-
D
L
-
K
M
Q
T
S
V
A
G
L
F
A
A
G
D
L
R
K
D
A
P
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
L
S
A
M
A
Y
I
---
E
S
-----------
98
HHSearch
83.70
44%
-82
- C2 -
2Q7V
2
?
A:
[4-313]
--
P
T
A
H
D
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
-
S
-
T
L
I
L
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
-
P
E
P
-
I
A
-
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
V
E
M
D
-
E
V
Q
G
V
-
Q
H
D
--
A
TSHPY
P
--
F
T
----
V
R
G
----
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
----
F
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
A
Q
A
R
A
F
-
A
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
A
---
D
---
S
--
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
-
D
------
T
V
S
-
L
R
D
D
G
Y
V
-
D
V
-
R
D
-
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
Y
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
---
A
A
-----------
22
PsiBlast_CBE
83.64
44%
-90
- C2 -
2A87
5
TRXB_MYCTU
B:
[15-318]
-------
R
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
-
A
-
P
L
V
F
E
G
-----
T
----
S
-----
F
-----
G
G
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
R
N
-
G
-
I
T
-
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
L
R
M
E
-
D
V
E
S
V
S
L
H
G
--
P
-----
L
--
K
S
----
V
V
T
---
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
----
L
L
G
----
R
G
V
S
S
C
A
T
C
D
G
--
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
-
I
M
L
D
R
A
R
N
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
D
G
D
----
T
--
T
--
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
-
E
------
A
I
D
-
V
D
P
D
G
Y
V
L
V
Q
-
G
R
-
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
A
E
H
----------
2
PsiBlast_PDB
83.56
45%
-89
- C2 -
2Q7V
2
?
A:
[9-314]
-------
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
-
S
-
T
L
I
L
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
P
E
-
P
-
I
A
-
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
V
E
M
D
-
E
V
Q
G
V
-
Q
H
D
--
A
-----
T
--
S
H
PYP
F
T
V
R
---
G
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
----
F
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
-
V
A
Q
A
R
A
F
A
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
----
A
D
--
S
--
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
-
D
------
T
V
S
-
L
R
D
D
G
Y
V
-
D
V
-
R
D
-
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
Y
R
Q
L
A
T
S
V
G
----
A
G
T
R
A
A
M
M
T
---
E
R
Q
L
A
A
L
------
97
HHSearch
83.37
43%
-83
- C2 -
1VDC
2
TRXB1_ARATH
A:
[4-325]
--
L
E
T
H
N
T
R
L
C
I
V
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
-
K
-
P
L
L
F
E
G
WMAND
I
----
A
-----
P
-----
G
G
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
-
P
E
G
-
I
L
-
G
V
E
L
T
D
K
F
R
K
Q
S
E
R
F
G
T
T
I
F
T
E
-
T
V
T
K
V
-
D
F
S
--
S
K----
P
--
F
K
----
L
F
T
----
D
S
K
A
I
L
A
D
A
V
I
L
A
I
G
A
V
A
K
R
L
S
F
V
G
S
G
E
VLGG
F
W
N
----
R
G
I
S
A
C
A
V
C
D
G
AA
P
--
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
M
E
E
A
N
F
L
T
K
Y
G
S
K
V
Y
I
I
H
R
R
D
A
F
R
A
S
K
-
I
M
Q
Q
R
A
L
S
N
P
K
I
D
V
I
W
N
S
S
V
V
E
--
A
Y
G
D
---
G
E
RD
V
--
L
G
G
L
K
V
K
N
V
V
T
G
D
V
S
D
L
K
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
F
L
D
-
G
------
G
V
E
-
L
D
S
D
G
Y
V
-
V
T
-
K
P
G
T
T
Q
T
S
V
P
G
V
F
A
A
G
D
V
Q
D
K
K
Y
R
Q
A
I
T
A
A
G
T
G
C
M
A
A
L
D
A
E
H
Y
L
---
Q
E
I
----------
55
PsiBlast_CBE
83.16
40%
-98
- C2 -
2WHD
3
?
B:
[33-343]
---------
V
C
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
-
K
-
P
V
L
F
E
G
-----
W
----
M
-----
A
NDIAA
G
G
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
-
P
-
T
G
I
M
-
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
T
N
I
L
S
E
-
T
V
T
E
V
D
F
S
A
--
R
-----
P
--
F
R
-----
V
T
---
S
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
----
Y
W
N
----
R
G
I
S
A
C
A
V
C
D
G
--
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
-
I
M
Q
A
R
A
L
S
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
G
---
G
G
--
P
--
L
A
G
V
K
V
K
N
L
V
T
G
E
V
S
D
L
Q
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
-
F
L
-
N
GQ----
L
E
L
-
H
A
D
-
G
Y
V
-
A
T
-
K
P
G
S
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
D
K
K
Y
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
---
Q
E
V
----------
21
PsiBlast_CBE
83.14
45%
-90
- C2 -
2Q7V
2
?
B:
[9-314]
-------
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
-
S
-
T
L
I
L
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
P
E
-
P
-
I
A
-
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
V
E
M
D
-
E
V
Q
G
V
-
Q
H
D
--
A
-----
T
--
S
H
PYP
F
T
V
R
---
G
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
----
F
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
-
V
A
Q
A
R
A
F
A
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
----
A
D
--
S
--
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
-
D
------
T
V
S
-
L
R
D
D
G
Y
V
-
D
V
-
R
D
-
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
Y
R
Q
L
A
T
S
V
G
----
A
G
T
R
A
A
M
M
T
---
E
R
Q
L
A
A
L
------
19
PsiBlast_PDB
83.07
37%
-90
- C2 -
3R9U
2
?
A:
[6-314]
--------
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
K
N
-
V
V
M
F
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
T
S
S
S
E
I
E
N
Y
P
G
V
-
A
-
Q
-
V
M
D
G
I
S
F
M
A
P
W
S
E
Q
C
M
R
F
G
L
K
H
E
M
V
-
G
V
E
Q
I
-
L
K
N
--
S
-----
D
G
S
F
T
----
I
K
L
---
E
G
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
A
P
K
K
A
G
F
K
G
E
D
E
----
F
F
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
P
-
S
T
V
E
K
V
K
K
N
E
K
I
E
L
I
T
S
A
S
V
D
E
--
V
Y
G
D
---
K
M
--
G
--
V
A
G
V
K
-
V
K
L
K
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
R
N
E
I
L
K
-
Q
DDSKF-
L
C
N
-
M
E
E
G
G
Q
V
-
S
V
-
D
L
-
K
M
Q
T
S
V
A
G
L
F
A
A
G
D
L
R
K
D
A
P
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
L
S
A
M
A
Y
I
---
E
S
L
----------
56
PsiBlast_CBE
82.89
40%
-97
- C2 -
2WHD
3
?
A:
[33-343]
---------
V
C
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
-
K
-
P
V
L
F
E
G
-----
W
----
M
-----
A
NDIAA
G
G
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
-
P
-
T
G
I
M
-
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
T
N
I
L
S
E
-
T
V
T
E
V
D
F
S
A
--
R
-----
P
--
F
R
-----
V
T
---
S
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
----
Y
W
N
----
R
G
I
S
A
C
A
V
C
D
G
--
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
-
I
M
Q
A
R
A
L
S
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
G
---
G
G
--
P
--
L
A
G
V
K
V
K
N
L
V
T
G
E
V
S
D
L
Q
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
-
F
L
-
N
GQ----
L
E
L
-
H
A
D
-
G
Y
V
-
A
T
-
K
P
G
S
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
D
K
K
Y
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
---
Q
E
V
----------
16
PsiBlast_PDB
82.73
41%
-94
- C2 -
4JNQ
2
?
A:
[29-338]
---------
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
M
L
-
K
-
P
V
V
I
A
G
-----
L
----
Q
-----
Q
-----
G
G
Q
L
M
I
T
T
D
V
E
N
Y
P
G
Y
A
E
-
P
-
V
Q
-
G
P
W
M
M
E
Q
M
A
R
Q
A
E
N
V
G
A
Q
I
V
H
D
-
I
I
T
E
V
E
T
T
V
--
R
-----
P
--
F
R
----
L
K
G
---
D
S
G
T
I
Y
T
C
D
A
L
I
I
A
T
G
A
Q
A
K
W
L
G
L
E
S
E
Q
T
----
F
M
G
----
G
G
V
S
A
C
A
T
C
D
G
--
F
--
F
Y
R
G
K
D
V
V
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
H
I
A
K
S
V
T
I
V
H
R
R
D
G
F
R
A
E
K
-
I
M
Q
D
R
L
L
S
R
E
N
V
S
V
V
W
N
S
V
I
D
E
--
I
L
G
T
E
AR
G
A
--
T
--
V
T
G
V
R
L
K
N
I
V
T
G
E
T
Q
E
R
A
T
H
G
V
F
I
A
I
G
H
A
P
A
V
S
L
F
E
-
G
------
K
L
K
-
Q
K
P
N
G
Y
L
-
W
T
A
P
D
-
S
T
A
T
D
V
P
G
I
F
A
A
G
D
V
T
D
D
I
Y
R
Q
A
V
T
A
A
G
M
G
C
M
A
A
L
E
A
E
R
W
L
A
A
Q
E
------------
93
HHSearch
82.55
38%
-96
- C2 -
2Q0L
2
TRXB_HELPY
A:
[1-310]
------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
-
K
N
A
V
L
F
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
-
K
E
V
-
V
S
-
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
M
T
-
A
V
Q
R
V
-
S
K
K
--
D
S----
H
--
F
V
----
I
L
A
---
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
----
Y
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
-
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
---
A
S
--
G
--
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
-
Q
EDNSM-
L
C
K
-
C
D
E
Y
G
S
I
-
V
V
-
D
F
-
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
I
F
A
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
---
E
H
-----------
14
PsiBlast_PDB
82.45
37%
-95
- C2 -
2Q0L
2
TRXB_HELPY
A:
[3-310]
--------
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
N
-
A
V
L
F
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
-
K
-
E
-
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
M
T
-
A
V
Q
R
V
-
S
K
K
D-
S
-----
H
--
F
V
----
I
L
A
---
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
----
Y
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
-
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
---
A
S
--
G
--
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
-
D
V
N
N
A
V
L
-
K
QEDNSM
L
C
K
-
C
D
E
Y
G
S
I
-
V
V
-
D
F
-
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
I
F
A
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
---
E
H
-----------
30
PsiBlast_CBE
82.26
39%
-88
- C2 -
4CBQ
8
?
B:
[3-312]
-----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
-
P
V
M
Y
E
G
FMAG-
G
----
V
-----
A
A----
G
G
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
P
N
-
G
-
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
I
I
T
E
-
T
I
D
H
V
D
F
S
T
--
Q
-----
P
--
F
K
----
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
-
T
M
Q
E
R
V
L
N
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
---
G
D
--
L
--
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
------
Q
V
K
-
T
A
D
D
G
Y
I
-
L
T
--
E
-
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
------------
31
PsiBlast_CBE
82.12
39%
-90
- C2 -
4A65
6
?
B:
[3-312]
-----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
-
P
V
M
Y
E
G
FMAG-
G
----
V
-----
A
A----
G
G
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
P
N
-
G
-
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
I
I
T
E
-
T
I
D
H
V
D
F
S
T
--
Q
-----
P
--
F
K
----
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
-
T
M
Q
E
R
V
L
N
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
---
G
D
--
L
--
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
------
Q
V
K
-
T
A
D
D
G
Y
I
-
L
T
--
E
-
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
------------
32
PsiBlast_CBE
82.06
39%
-91
- C2 -
4A5L
3
?
B:
[3-312]
-----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
-
P
V
M
Y
E
G
FMAG-
G
----
V
-----
A
A----
G
G
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
P
N
-
G
-
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
I
I
T
E
-
T
I
D
H
V
D
F
S
T
--
Q
-----
P
--
F
K
----
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
-
T
M
Q
E
R
V
L
N
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
---
G
D
--
L
--
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
------
Q
V
K
-
T
A
D
D
G
Y
I
-
L
T
--
E
-
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
------------
13
PsiBlast_PDB
81.79
37%
-96
- C2 -
2Q0K
3
TRXB_HELPY
A:
[3-310]
--------
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
N
-
A
V
L
F
E
K
-----
G
----
M
-----
P
-----
G
G
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
-
K
-
E
-
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
M
T
-
A
V
Q
R
V
-
S
K
K
D-
S
-----
H
--
F
V
----
I
L
A
---
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
----
Y
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
-
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
---
A
S
--
G
--
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
-
D
V
N
N
A
V
L
-
K
QEDNSM
L
C
K
-
C
D
E
Y
G
S
I
-
V
V
-
D
F
-
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
I
F
A
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
---
E
H
-----------
94
HHSearch
80.95
40%
-85
- C2 -
3ITJ
3
TRXB1_YEAST
A:
[21-336]
-----
V
H
N
K
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
-
K
-
P
I
L
Y
E
G
M----
M
ANGI
A
-----
A
-----
G
G
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
-
P
D
G
-
L
T
-
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
I
I
T
E
-
T
V
S
K
V
-
D
L
S
--
S
K----
P
--
F
K
----
L
W
T
EFN
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
-
I
M
Q
K
R
A
E
K
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
--
A
K
G
D
---
G
K
--
L
--
L
N
A
L
R
I
K
N
T
K
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
------
Q
V
D
-
T
D
E
A
G
Y
I
-
K
T
-
V
P
G
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---
T
S
-----------
102
HHSearch
77.46
38%
-81
- C2 -
3CTY
2
?
A:
[14-316]
----
E
R
D
F
D
V
V
I
V
G
A
G
A
A
G
F
S
A
A
V
Y
A
A
R
S
G
F
-
S
-
V
A
I
L
D
K
-----
A
----
V
-----
A
-----
G
G
L
T
A
E
A
P
L
V
E
N
Y
L
G
F
-
K
-
S
-
I
V
-
G
S
E
L
A
K
L
F
A
D
H
A
A
N
Y
-
A
K
I
R
E
G
V
E
V
R
S
I
-
K
K
T
--
Q
G----
G
--
F
D
----
I
E
T
----
N
D
D
T
Y
H
A
K
Y
V
I
I
T
T
G
T
T
H
K
H
L
G
V
K
G
E
S
E
----
Y
F
G
----
K
G
T
S
Y
C
S
T
C
D
G
--
Y
--
L
F
K
G
K
R
V
V
T
I
G
G
G
N
S
G
A
I
A
A
I
S
M
S
E
Y
V
K
N
V
T
I
I
E
Y
M
P
K
Y
M
C
E
N
-
A
Y
V
Q
E
I
-
K
K
R
N
I
P
Y
I
M
N
A
Q
V
T
E
--
I
V
G
D
---
G
K
--
K
--
V
T
G
V
K
Y
K
D
R
T
T
G
E
E
K
L
I
E
T
D
G
V
F
I
Y
V
G
L
I
P
Q
T
S
F
L
K
D
S
------
G
V
K
-
L
D
E
R
G
Y
I
-
V
V
-
D
S
-
R
Q
R
T
S
V
P
G
V
Y
A
A
G
D
V
T
S
G
N
F
A
Q
I
A
S
A
V
G
D
G
C
K
A
A
L
S
L
Y
S
D
S
---
I
------------