@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2600: (2016-04-05 )
MEIKLEQLGYCYQKNSPFEKRALLDVNVSFDSGSYSAIIGHTGSGKSTLLQHLNALLMPTEGKITVGDREIVAGVKQKKLRDLRKKVGIVFQFPEAQLFEETVEKDICFGPMNFGVSEEDAKLRAKKVIYEVGLTEEILSRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPTAGLDPHGREEIMEMFYNLHKEKGLTTVLVTHSMEDAARYAEKIVLMKAGTVLQIGTPREIFAKPDELVDLGLSVPDVVRFQGLFERKFDVKLTKTCLTIDELTTEMAPYLAKGGA
Atome Classification :
(46 SA)
--.........10........20....-....30........40........50........60........70---------....-------------....80.------.......90-..----..----.....100.-........110...------.--.-...--.120.-......130--...-...--.140.......150.......160-.......170.......180.......190.......200.......210.......220........230.......240.......250.......260.......270.......280......----------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
E
I
K
L
E
QL
G
Y
C
YQKNSPFE
K
R
A
L
L
D
-
V
N
V
S
FDSG
S
Y
S
A
I
I
GHTGS
G
K
S
T
L
L
Q
H
L
N
A
LLMPTEG
K
I
T
VG
D
R
E
I
---------
V
A
G
V
-------------
K
Q
K
K
L
R
D
------
L
R
K
KV
G
I
V
--
F
Q----FP----
E
A
Q
L
F
E
--
E
-
T
V
E
KDICFG--PMN------F--G-VS
E
--
E
D
A
K
L
-
R
A
K
K
V
I
YEV--GL
T
-
E
E
I
--
L
SRSPFELSGG
Q
M
R
R
V
A
I
A
G
V
LAM-DP
E
V
L
V
L
DEPTAGLDPH
G
R
E
E
I
M
E
M
F
Y
N
L
H
K
EKG
L
T
T
V
L
V
TH
S
M
E
D
A
A
R
Y
A
E
K
I
V
L
M
KA-G
T
V
L
QIG
T
P
R
E
IFAK
P
D
E
L
V
D
LGLSV
P
D
V
V
R
F
Q
G
L
F
ERKFD
V
K
L
T
K
T
C
L
T
I
D
E
L
T
T
E
M
A
P
Y
LAKGGA----------------------------------------------------------------------------
1
PsiBlast_PDB
92.30
51%
-106
- C1 -
4HUQ
-
ECFA2_LACBA
A:
[2-285]
---
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
-
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
I
K
I
D
E
F
T
I
---------
T
P
E
T
-------------
T
N
A
A
L
K
P
------
L
R
Q
H
V
G
M
V
--
F
Q
----
F
P
----
E
N
Q
L
F
E
--
E
-
T
V
R
Q
D
I
A
F
G
--
P
K
N
------
F
--
G
-
M
A
D
--
A
D
A
L
A
-
L
A
D
E
M
L
T
T
V
--
G
L
D
-
Q
S
Y
--
A
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
-
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
L
F
A
R
L
H
Q
E
Q
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
H
E
-
G
R
L
M
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
-
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
A
D
Y
L
A
Q
Q
W
A
Q
R
------------------------------------------------------------------------------
2
PsiBlast_PDB
90.57
51%
-100
- C1 -
4HZU
-
ECFA2_LACBA
B:
[2-285]
---
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
-
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
I
K
I
D
E
F
T
I
---------
T
P
E
T
-------------
T
N
A
A
L
K
P
------
L
R
Q
H
V
G
M
V
--
F
Q
----
F
P
----
E
N
Q
L
F
E
--
E
-
T
V
R
Q
D
I
A
F
G
--
P
K
N
------
F
--
G
-
M
A
D
--
A
D
A
L
A
-
L
A
D
E
M
L
T
T
V
--
G
L
D
-
Q
S
Y
--
A
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
-
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
L
F
A
R
L
H
Q
E
Q
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
H
E
-
G
R
L
M
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
-
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
A
D
Y
L
A
Q
Q
W
A
Q
R
------------------------------------------------------------------------------
3
PsiBlast_PDB
88.75
49%
-101
- C1 -
4MKI
4
ECFA2_CALS4
B:
[5-284]
--
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
-
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
---------
T
D
---------------
K
K
V
S
L
K
D
------
I
R
K
Q
V
G
L
V
--
F
Q
----
Y
P
----
E
Y
Q
L
F
E
--
E
-
T
V
F
K
D
I
A
F
G
--
P
S
N
------
L
--
G
-
L
S
E
--
E
E
V
K
E
-
R
V
Y
E
A
M
E
I
V
--
G
I
S
-
K
E
L
--
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
-
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
-
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
-
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
K
E
H
I
L
R
Y
L
---------------------------------------------------------------------------------
21
PsiBlast_CBE
87.81
49%
-102
- C1 -
4MKI
4
ECFA2_CALS4
A:
[5-284]
--
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
-
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
---------
T
D
---------------
K
K
V
S
L
K
D
------
I
R
K
Q
V
G
L
V
--
F
Q
----
Y
P
----
E
Y
Q
L
F
E
--
E
-
T
V
F
K
D
I
A
F
G
--
P
S
N
------
L
--
G
-
L
S
E
--
E
E
V
K
E
-
R
V
Y
E
A
M
E
I
V
--
G
I
S
-
K
E
L
--
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
-
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
-
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
-
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
K
E
H
I
L
R
Y
L
---------------------------------------------------------------------------------
4
PsiBlast_PDB
78.05
36%
-114
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[8-254]
----
L
K
V
E
E
L
N
Y
N
Y
S
D
G
T
----
H
A
L
K
G
-
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
-----------
D
Y
-------------
S
R
K
G
I
M
K
------
L
R
E
S
I
G
I
V
--
F
Q
----
D
P
----
D
N
Q
L
F
S
--
A
-
S
V
Y
Q
D
V
S
F
G
--
A
V
N
------
M
--
K
-
L
P
E
--
D
E
I
R
K
-
R
V
D
N
A
L
K
R
T
--
G
I
--
E
H
L
--
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
-
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
-
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
------------------------------------------------------------------------------------------------------------
115
HHSearch
76.51
37%
-110
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-254]
---
I
L
K
V
E
E
L
N
Y
N
Y
S
D
G
----
T
H
A
L
K
G
-
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
---------
D
Y
S
---------------
R
K
G
I
M
K
------
L
R
E
S
I
G
I
V
--
F
Q
----
D
P
----
D
N
Q
L
F
S
--
A
-
S
V
Y
Q
D
V
S
F
G
--
A
V
N
------
M
--
K
-
L
P
E
--
D
E
I
R
K
-
R
V
D
N
A
L
K
R
T
--
G
I
E
--
H
L
--
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
-
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
-
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
65.04
34%
-96
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[15-233]
---------------
Q
N
T
P
V
----
L
N
D
-
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
---------
F
S
---------------
K
N
T
N
L
P
V
------
R
E
R
R
L
G
Y
L
--
V
Q
----------
E
G
V
L
F
P
--
H
L
T
V
Y
R
N
I
A
Y
G
--
L
G
N
------
G
--
K
-
G
R
T
--
A
Q
E
R
Q
-
R
I
E
A
M
L
E
L
T
--
G
I
S
-
E
-
L
--
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
----------------------------------------------------------------------------------------------------------------------------
131
Fugue
63.62
33%
-99
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
----
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
---
H
E
V
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
N
L
V
R
D
KDGQLKVA
D
K
N
Q
L
R
L
------
L
R
T
-
R
-
L
T
--
M
V
----
F
Q
----
H
F
N
L
W
S
--
H
-
M
T
V
L
E
N
V
M
E
--
A
P
I
------
Q
VL
G
-
L
S
K
--
H
D
A
R
E
-
R
A
L
K
Y
L
A
K
V
--
G
I
D
-
E
R
A
QG--
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
S
--------------------------------
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
-----------------------------------------------------------------------------
5
PsiBlast_PDB
63.21
34%
-96
- C1 -
2YZ2
-
ECFA2_THEMA
A:
[1-230]
--
M
R
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
-
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
-------
D
V
---------
L
Y
D
G
-------------
E
R
K
K
G
Y
E
------
I
R
R
N
I
G
I
A
--
F
Q
----
Y
P
----
E
D
Q
F
F
A
--
E
-
R
V
F
D
E
V
A
F
A
--
V
K
N
------
F
--
Y
-
P
D
R
--
D
P
V
P
L
--
V
K
K
A
M
E
F
V
--
G
L
D
F
D
S
F
--
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
-
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
-
G
K
K
V
F
D
G
T
R
M
E
F
L
E
K
Y
D
------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
63.07
36%
-102
* C1 *
2OLJ
4
?
A:
[23-250]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
K
---------------
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
----
R
F
----
N
--
L
F
P
H-
M
-
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
--
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
62.79
34%
-98
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[15-238]
---------------
Q
N
T
P
V
----
L
N
D
-
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
---------
F
S
---------------
K
N
T
N
L
P
V
------
R
E
R
R
L
G
Y
L
--
V
Q
----------
E
G
V
L
F
P
--
H
L
T
V
Y
R
N
I
A
Y
G
--
L
G
N
------
G
--
K
-
G
R
T
--
A
Q
E
R
Q
-
R
I
E
A
M
L
E
L
T
--
G
I
S
-
E
-
L
--
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
----------------------------------------------------------------------------------------------------------------------------
109
HHSearch
62.30
34%
-94
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-235]
---
A
L
H
I
G
H
L
S
K
S
F
Q
N
-----
T
P
V
L
N
D
-
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
---------
F
S
K
---------------
N
T
N
L
P
V
------
R
E
R
R
L
G
Y
L
--
V
Q
----
E
G
----
V
--
L
F
P
H-
L
-
T
V
Y
R
N
I
A
Y
G
--
L
G
N
------
G
--
K
-
G
R
T
--
A
Q
E
R
Q
-
R
I
E
A
M
L
E
L
T
--
G
I
S
--
E
L
--
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
-------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.77
34%
-93
- C1 -
4HLU
2
ECFA2_THEMA
A:
[5-232]
----
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
-
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
-------
D
V
---------
L
Y
D
G
-------------
E
R
K
K
G
Y
E
------
I
R
R
N
I
G
I
A
--
F
Q
----
Y
P
----
E
D
Q
F
F
A
--
E
-
R
V
F
D
E
V
A
F
A
--
V
K
N
------
F
--
Y
-
P
D
R
--
D
P
V
P
L
--
V
K
K
A
M
E
F
V
--
G
L
D
F
D
S
F
--
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
-
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
-
G
K
K
V
F
D
G
T
R
M
E
F
L
E
K
Y
D
------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
61.45
32%
-108
- C1 -
1V43
-
?
A:
[12-240]
---
E
V
K
L
E
N
L
T
K
R
F
G
N
-----
F
T
A
V
N
K
-
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
---------
T
Y
L
-------------------
P
P
------
K
D
R
N
I
S
M
V
--
F
Q
---------------
H
--
M
-
T
V
Y
E
N
I
A
F
P
--
L
--------
K
--
K
-
F
P
K
--
D
E
I
D
K
-
R
V
R
W
A
A
E
L
L
--
Q
I
E
--
E
L
--
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
-
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
-------------------------------------------------------------------------------------------------------------------------------
129
Fugue
61.36
30%
-80
- C1 -
1Z47
1
?
A:
[11-355]
GS
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
----
A
R
S
V
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
----------------------------
T
D
L
P
P
------
Q
K
R
N
V
G
L
V
--
F
Q
-----
N
----
Y
A
L
F
Q
H
--
M
-
T
V
Y
D
N
V
S
F
G
--
L
R
E
------
K
--
R
-
V
P
K
--
D
E
M
D
A
-
R
V
R
E
L
L
R
F
M
--
R
L
--
E
S
Y
--
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
-
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
--------
L
F
V
A
S
F
I
G
-
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
51
PsiBlast_CBE
61.33
36%
-104
- C1 -
1L2T
4
Y796_METJA
B:
[20-223]
-----------------------
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---------------
I
-------------
K
T
N
D
L
D
D
DELTKI
R
R
D
K
I
G
F
V
--
F
Q
Q---
F
N
----
L
I
P
L
L
T
AL
E
-
N
V
E
L
P
L
I
F
---
K
Y
R
------
G
--
A
-
M
S
G
--
E
E
R
R
K
-
R
A
L
E
C
L
K
M
A
--
E
L
E
-
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
61.10
34%
-102
- C1 -
1Z47
1
?
A:
[13-237]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
----
A
R
S
V
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
---------
T
D
-------------------
L
P
P
------
Q
K
R
N
V
G
L
V
--
F
Q
----
N
Y
----
A
--
L
F
Q
H-
M
-
T
V
Y
D
N
V
S
F
G
--
L
R
E
------
K
--
R
-
V
P
K
--
D
E
M
D
A
-
R
V
R
E
L
L
R
F
M
--
R
L
E
--
S
Y
--
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
-
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
-------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
60.79
28%
-98
- C1 -
1OXX
21
?
K:
[3-232]
---
R
I
I
V
K
N
V
S
K
V
F
K
K
G
---
K
V
V
A
L
D
N
-
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------
A
S
N
G
--------------
K
L
I
V
P
P
------
E
D
R
K
I
G
M
V
--
F
Q
----
T
W
----
A
--
L
Y
P
N-
L
-
T
A
F
E
N
I
A
F
P
--
L
T
N
------
M
--
K
-
M
S
K
--
E
E
I
R
K
-
R
V
E
E
V
A
K
I
L
--
D
I
H
--
H
V
--
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
-
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
-
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
-------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
60.75
34%
-92
- C1 -
4HLU
3
ECFA2_THEMA
B:
[5-232]
----
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
-
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
-------
D
V
---------
L
Y
D
G
-------------
E
R
K
K
G
Y
E
------
I
R
R
N
I
G
I
A
--
F
Q
----
Y
P
----
E
D
Q
F
F
A
--
E
-
R
V
F
D
E
V
A
F
A
--
V
K
N
------
F
--
Y
-
P
D
R
--
D
P
V
P
L
--
V
K
K
A
M
E
F
V
--
G
L
D
F
D
S
F
--
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
-
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
-
G
K
K
V
F
D
G
T
R
M
E
F
L
E
K
Y
D
------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
60.48
36%
-108
- C1 -
3TIF
6
Y796_METJA
B:
[20-223]
-----------------------
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---------------
I
-------------
K
T
N
D
L
D
D
DELTKI
R
R
D
K
I
G
F
V
--
F
Q
Q---
F
N
----
L
I
P
L
L
T
AL
E
-
N
V
E
L
P
L
I
F
---
K
Y
R
------
G
--
A
-
M
S
G
--
E
E
R
R
K
-
R
A
L
E
C
L
K
M
A
--
E
L
E
-
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.28
36%
-104
- C1 -
3TIF
7
Y796_METJA
A:
[20-223]
-----------------------
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---------------
I
-------------
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
--
F
Q
Q---
F
N
----
L
I
P
L
L
T
A
L
E
-
N
V
E
L
P
L
I
F
---
K
Y
R
------
G
--
A
-
M
S
G
--
E
E
R
R
K
-
R
A
L
E
C
L
K
M
A
--
E
L
E
-
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.90
36%
-95
- C1 -
4U00
3
?
A:
[23-231]
----------------------------
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
---------
K
----------------
D
D
R
A
L
R
E
------
I
R
R
E
V
G
M
V
--
F
Q
----------
Q
F
N
L
F
P
--
H
M
T
V
L
E
N
V
T
L
A
--
P
M
R
------
V
--
R
R
W
P
R
--
E
K
A
E
K
-
K
A
L
E
L
L
E
R
V
--
G
I
L
-
D
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-----------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.70
36%
-105
- C1 -
1L2T
4
Y796_METJA
A:
[20-223]
-----------------------
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---------------
I
-------------
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
--
F
Q
Q---
F
N
----
L
I
P
L
L
T
A
L
E
-
N
V
E
L
P
L
I
F
---
K
Y
R
------
G
--
A
-
M
S
G
--
E
E
R
R
K
-
R
A
L
E
C
L
K
M
A
--
E
L
E
-
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.17
36%
-112
- C1 -
4YMU
2
?
J:
[20-226]
----------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------
N
N
G
---------------
K
V
N
I
N
K
------
V
R
Q
K
V
G
M
V
--
F
Q
HFNL
F
P
----
H
L
T
A
I
E
--------
N
I
T
L
A
--
P
V
K
------
V
--
K
K
M
N
K
--
K
E
A
E
E
-
L
A
V
D
L
L
A
K
V
--
G
L
L
-
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
--------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.80
36%
-109
- C1 -
4YMV
1
?
J:
[20-226]
----------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------
N
N
G
---------------
K
V
N
I
N
K
------
V
R
Q
K
V
G
M
V
--
F
Q
HFNL
F
P
----
H
L
T
A
I
E
--------
N
I
T
L
A
--
P
V
K
------
V
--
K
K
M
N
K
--
K
E
A
E
E
-
L
A
V
D
L
L
A
K
V
--
G
L
L
-
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
--------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
57.62
36%
-113
- C1 -
4YMU
2
?
A:
[20-226]
----------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------
N
N
G
---------------
K
V
N
I
N
K
------
V
R
Q
K
V
G
M
V
--
F
Q
HFNL
F
P
----
H
L
T
A
I
E
--------
N
I
T
L
A
--
P
V
K
------
V
--
K
K
M
N
K
--
K
E
A
E
E
-
L
A
V
D
L
L
A
K
V
--
G
L
L
-
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
--------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
57.16
36%
-100
- C1 -
3C4J
3
?
A:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
56.85
36%
-109
- C1 -
4YMV
1
?
A:
[20-226]
----------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------
N
N
G
---------------
K
V
N
I
N
K
------
V
R
Q
K
V
G
M
V
--
F
Q
HFNL
F
P
----
H
L
T
A
I
E
--------
N
I
T
L
A
--
P
V
K
------
V
--
K
K
M
N
K
--
K
E
A
E
E
-
L
A
V
D
L
L
A
K
V
--
G
L
L
-
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
--------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
56.74
36%
-103
- C1 -
2OLK
2
?
B:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
56.24
36%
-107
- C1 -
3C41
3
?
K:
[22-229]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
55.97
31%
-97
- C1 -
1G6H
3
LIVG_METJA
A:
[19-239]
--------------------
E
F
K
A
L
D
G
-
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
K
D
I
---------
T
-----------------
N
K
E
P
A
E
------
L
Y
H
-
Y
G
I
V
R
T
F
Q
----
T
P
Q
P
L
K
E
M
T
V
L
E
--
N
-
L
L
I
G
E
I
C
P
G
ES
P
L
N
S
L
F
Y
KK
W
--
I
-
P
K
E
--
E
E
M
V
E
-
K
A
F
K
I
L
E
F
L
--
K
L
S
-
H
-
L
--
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
-
K
A
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
-
G
Q
I
I
A
E
G
R
G
E
E
------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.97
36%
-102
- C1 -
2OLK
1
?
A:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.09
36%
-103
- C1 -
2OLJ
4
?
A:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
54.89
36%
-103
- C1 -
2OLK
1
?
D:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.78
36%
-100
- C1 -
3C41
3
?
J:
[22-229]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
54.43
36%
-106
- C1 -
2OLK
1
?
C:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
53.88
36%
-98
- C1 -
2Q0H
4
?
A:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
53.36
36%
-107
- C1 -
3C4J
4
?
B:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
53.01
32%
-89
- C1 -
2HYD
3
Y1866_STAAM
B:
[339-565]
---
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
---
E
A
P
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
--------------------------
K
D
F
L
T
G
S
------
L
R
N
Q
I
G
L
V
--
Q
Q
----------
D
N
I
L
F
S
--
D
-
T
V
K
E
N
I
L
L
G
--
R
P
T
------
A
--
T
-
D
E
E
VV
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
PQ
G
Y
D
-
T
E
V
--
G
E
R
G
-
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
-
T
I
T
H
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
52.89
34%
-96
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[4-231]
----
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
-
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
-------
D
V
---------
L
Y
D
G
-------------
E
--
K
G
Y
E
------
I
R
R
N
I
G
I
A
--
F
Q
----
Y
P
----
E
D
Q
F
F
A
--
E
-
R
V
F
D
E
V
A
F
A
--
V
K
N
------
F
--
Y
-
P
D
R
--
D
P
V
P
L
--
V
K
K
A
M
E
F
V
--
G
L
D
F
D
S
F
--
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
-
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
-
G
K
K
V
F
D
G
T
R
M
E
F
L
E
K
Y
D
------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
52.88
32%
-89
- C1 -
2HYD
3
Y1866_STAAM
A:
[339-565]
---
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
---
E
A
P
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
--------------------------
K
D
F
L
T
G
S
------
L
R
N
Q
I
G
L
V
--
Q
Q
----------
D
N
I
L
F
S
--
D
-
T
V
K
E
N
I
L
L
G
--
R
P
T
------
A
--
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
PQ
G
Y
D
-
T
E
V
--
G
E
R
G
-
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
-
T
I
T
H
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
50.59
36%
-104
- C1 -
2Q0H
4
?
B:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
49.66
36%
-96
- C1 -
2OLJ
3
?
B:
[43-250]
----------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------
K
A
---------------
K
D
T
N
L
N
K
------
V
R
E
E
V
G
M
V
--
F
Q
RFNL
F
P
----
H
M
--------
T
V
L
N
N
I
T
L
A
--
P
M
K
------
V
R-
K
-
W
P
R
--
E
K
A
E
A
-
K
A
M
E
L
L
D
K
V
--
G
L
K
-
D
K
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
44.32
35%
-102
- C1 -
1B0U
4
HISP_SALTY
A:
[45-244]
------------------------------------------------
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQ
L
K
V
A
-------------
D
K
N
Q
L
R
L
------
L
R
T
R
L
T
M
V
--
F
Q
----------
H
F
N
L
W
S
--
H
M
T
V
L
E
N
V
M
E
A
--
P
I
Q
V-----
L
--
G
-
L
S
K
--
H
D
A
R
E
-
R
A
L
K
Y
L
A
K
V
--
G
I
D
-
E
R
A
--
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
-
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
40.21
40%
-100
- C1 -
4HLU
3
ECFA1_THEMA
C:
[27-201]
------------------------
L
K
D
-
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
------
F
---------
L
D
G
S
-------------
P
A
D
P
F
L
-------
L
R
K
N
V
G
Y
V
--
F
Q
----
N
P
----
S
S
Q
I
I
G
--
A
-
T
V
E
E
D
V
A
F
S
--
L
E
I
------
M
--
G
-
L
D
E
--
S
E
M
R
K
-
R
I
K
K
V
L
E
L
V
--
G
L
S
-
G
-
L
--
A
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
-
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
-
K
N
E
G
K
G
I
I
L
V
T
H
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
37.96
40%
-100
- C1 -
4HLU
2
ECFA1_THEMA
D:
[27-201]
------------------------
L
K
D
-
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
------
F
---------
L
D
G
S
-------------
P
A
D
P
F
L
-------
L
R
K
N
V
G
Y
V
--
F
Q
----
N
P
----
S
S
Q
I
I
G
--
A
-
T
V
E
E
D
V
A
F
S
--
L
E
I
------
M
--
G
-
L
D
E
--
S
E
M
R
K
-
R
I
K
K
V
L
E
L
V
--
G
L
S
-
G
-
L
--
A
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
-
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
-
K
N
E
G
K
G
I
I
L
V
T
H
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------