@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2638: (2016-04-05 )
MPEKNIVLIGAGYAGVHAAKKLAKKYKKDKDVNITLIDRHSYHTMMTELHEVAGGRVEPTAIQYDLRRLFNRTKVNLVTDNVTHVDHDKKVVTTEHGSYPFDYLVLGMGGEPNDFGTPGVGENGFTLWSWEDSVKLRNHIEETVTKASREQDVEKRKAMLTFVVCGSGFTGIEMVGELLEWKDRLAKDNKIDASEIKLVVVEAAPTILNMLERRDADKAERYMVKKGIEIMKNAAIVEVKPESIVLKSGEELPTSTLIWTAGVRANSDTKDYGMESARAGRLKVNQYMEAEGLKDVYVVGDLAYFEDEEGKPTPQIVEGAEQTALTAAKSIIVEMSGTGEKEPFQGKYHGVMVSIGAKYGVAHLGGMHLSGWFAILMKHMVNLYYFFGIRSGYYMWQYIMHEFFHIKDHRNIFRGWTSRYGNVLWVLPLRVYLGWFWIDEALSKIYGETTWDKVSITNLKPLFNGIGSDSWLTATTSKMPFEWLQTAATSGASQAAGDAAGAAATNVTTPILSHMPGWFQWIMELLMPNLDVALVMQKVVPFVELAIGLAMVVGLFTWLVSIGSAGFLVMFTLSAMLGWDKFWALPASIALLNGAGRTFGLDYWAVPWFQKHLGHWWYGKPRSVYRDK
Atome Classification :
(20 SA)
--------.........10........20.-.......30........40...-.-.-.-.-.50...-....-.-----------60.........70...---------...-.--.-80.........90....---------------------.------.-..100--.........110...-....-----120.--.......130.......140......--.150.......160.......170.......180...-.....190.......200.......-210........220.......230.......240-----------------------.---....---.--------.250-------........260.....-.-.270-----...-....280---........290.......300......-.--310.........320.......330.......340......-.350........360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MPEK
N
I
V
L
I
GAG
Y
A
G
V
H
A
A
K
K
L
-
A
K
K
YKKDKDV
N
I
T
L
IDRH
S
Y
H
T
-
M
-
M
-
T
-
E
-
L
H
E
VAG-GRVE-
P
-----------
T
-
A
I
Q
Y
D
L
R
R
L
FNRT
K
---------
V
N
L
-
V
--T-D-NVTHVDHD
K
K
V
V
T
TE---------------------H------G-SYP----
F
D
Y
L
V
L
GMGGEPNDF-GTPG-----VG-E--N
G
F
T
L
WSWE
D
S
V
K
L
R
N
H
I
E
E
T
V
T
K
A
S
--
R
E
Q
D
V
E
K
R
K
A
M
L
T
F
V
V
CGSGF
T
G
I
E
M
V
G
E
L
L
E
W
-
K
D
R
-LAKDNKI
D
A
S
E
I
K
L
V
V
V
EA
A
P
T
I
L
N
-
M
-
L
E
RR
D
A
D
K
A
E
R
Y
M
V
K
K
G
I
E
I
MKN
A
A
I
V
E
VKPE-----------------------
S
---
I
V
LK---S--------GEE--------LPT
S
T
L
I
W
T
AGVRANS-D-TKDY-----GME-SARAGR----L
K
V
N
Q
Y
M
E
AEGL
K
D
V
Y
V
V
G
D
L
A
Y
FEDE-E--G--KPT
P
Q
I
VEG
A
E
Q
T
A
L
T
A
A
K
S
I
I
V
E
MSGTGEKEPFQGKY-H
G
-
V
M
V
S
IGAKYG
V
A
H
LGGM
H
L
S
G
W
F
A
I
L
M
K
H
M
V
N
L
Y
Y
F
F
GIRS
G
Y
Y
M
W
Q
Y
I
M
H
E
F
F
H
I
K
D
H
R
N
I
F
R
G
W
T
S
RYG
N
V
L
W
V
L
P
L
R
V
Y
L
G
W
F
W
I
D
E
A
L
S
K
I
YGETTW
D
K
V
SITN
L
K
P
L
F
NGIGSD
S
W
L
T
ATTSKM
P
F
E
W
L
Q
T
A
ATSGASQAAGDAAGAAATNV
T
T
P
I
L
SHM
P
G
W
F
Q
W
I
M
E
L
LMPNL
D
V
A
L
V
M
Q
K
V
V
P
F
V
E
L
A
I
G
L
A
M
V
V
G
L
F
T
W
L
V
S
IGSA
G
F
L
V
M
F
T
L
S
A
M
L
G
W
D
K
F
WAL
P
A
S
I
A
L
LNGAGRTF
G
L
DYW
A
V
P
W
F
Q
K
HL
G
H
WWYGKP
R
S
VYRDK
21
PsiBlast_CBE
94.45
32%
-88
- C2 -
4NWZ
1
?
C:
[3-385]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
-
Q
K
R
L
N
Y
N
-
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
-
I
-
T
-
T
-
E
-
L
H
Q
P
A
A
-
G
T
M
H
-
H
-----------
D
-
Q
A
R
V
G
I
K
E
L
I
D
E
K
K
---------
I
K
F
-
V
--
K
-
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
---------------------
N
------
G
-
E
L
H
----
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
-
G
I
E
G
-----
L
R
-
E
--
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
--
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
-
M
P
E
-
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----------------------
G
---
V
V
I
E
VDG
E
--------
E
E
E
--------
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
-
I
-
V
E
K
S
-----
G
F
E
-
T
M
R
-
G
R
----
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N-
N
--
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
-
G
S
M
T
P
F
K
P
H
I
-
R
G
-
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.40
32%
-89
- C2 -
4NWZ
1
?
A:
[3-385]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
-
Q
K
R
L
N
Y
N
-
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
-
I
-
T
-
T
-
E
-
L
H
Q
P
A
A
-
G
T
M
H
-
H
-----------
D
-
Q
A
R
V
G
I
K
E
L
I
D
E
K
K
---------
I
K
F
-
V
--
K
-
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
---------------------
N
------
G
-
E
L
H
----
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
-
G
I
E
G
-----
L
R
-
E
--
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
--
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
-
M
P
E
-
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----------------------
G
---
V
V
I
E
V
DG
E
--------
E
E
E
--------
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
-
I
-
V
E
K
S
-----
G
F
E
-
T
M
R
-
G
R
----
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N-
N
--
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
-
G
S
M
T
P
F
K
P
H
I
-
R
G
-
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
94.34
32%
-87
- C2 -
4NWZ
1
?
B:
[3-385]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
-
Q
K
R
L
N
Y
N
-
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
-
I
-
T
-
T
-
E
-
L
H
Q
P
A
A
-
G
T
M
H
-
H
-----------
D
-
Q
A
R
V
G
I
K
E
L
I
D
E
K
K
---------
I
K
F
-
V
--
K
-
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
---------------------
N
------
G
-
E
L
H
----
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
-
G
I
E
G
-----
L
R
-
E
--
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
--
A
E
P
E
---
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
G
I
E
F
V
G
E
L
A
D
R
-
M
P
E
-
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----------------------
G
---
V
V
I
E
VDG
E
--------
E
E
E
--------
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
-
I
-
V
E
K
S
-----
G
F
E
-
T
M
R
-
G
R
----
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N-
N
--
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
-
G
S
M
T
P
F
K
P
H
I
-
R
G
-
T
V
A
S
L
G
R
N
D
A
I
G
I
V
G
G
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
86.62
23%
-83
- C2 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
H
S
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
------
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
G
N
-------
V
T
Y
-
Y
--
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQA
E
P
------
A
-
E
I
K
----
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
-
L
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
-
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
K
H
EDG
K
I
T
E
E
T
--------
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
-----
F
K
K
-
I
P
E
Q
N
S
SKRG
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
G
L
P
-
P
--
T
------------
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
P
N
F
Q
K
I
D
-
L
L
-
F
E
E
N
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
I
R
S
G
K
R
T
F
Y
T
G
G
G
------------------
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
F
F
K
G
L
42
HHSearch
84.07
26%
-90
- C2 -
3NTD
2
?
A:
[1-337]
----------
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
-
R
R
L
S
---
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
-
F
-
A
-
N
C
G
-
L
P
Y
H
I
S
-
G
E
I
A
-
Q
R
----------
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
---------
V
E
V
R
V
--
K
-
H
-
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
RLLDG
S
---------------
E
------
Y
-
Q
E
S
----
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
-
P
I
P
G
-----
V
D
-
N
P-
L
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
Q
----------------
M
N
N
V
E
H
A
T
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
H
H
L
---------------
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
Y
Q
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
---
L
T
L
S
---
N
--------
G
E
L
--------
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
-
A
R
D
A
-----
G
L
A
-
I
G
E
L
G
G
----
I
K
V
N
A
M
M
Q
T
-
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
-
V
T-
G
Q
-
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.08
26%
-98
- C2 -
4G9K
1
NDI1_YEAST
A:
[13-352]
------------
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
------
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
---------
G
N
V
-
T
Y
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGL----
H
------
Q
-
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
-
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
-
V
H
Q
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
--------
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
-----
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.07
26%
-98
- C2 -
4GAP
2
NDI1_YEAST
A:
[13-352]
------------
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
------
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
---------
G
N
V
-
T
Y
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGL----
H
------
Q
-
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
-
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
-
V
H
Q
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
--------
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
-----
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.96
26%
-98
- C2 -
4G73
8
NDI1_YEAST
A:
[44-375]
------------
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
------
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
---------
G
N
V
-
T
Y
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGL----
H
------
Q
-
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
-
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
-
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
--------
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
-----
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.63
26%
-95
- C2 -
4G74
7
NDI1_YEAST
A:
[44-382]
------------
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
------
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
---------
G
N
V
-
T
Y
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGL----
H
------
Q
-
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
-
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
-
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
--------
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
-----
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.50
26%
-100
- C2 -
4G6G
6
NDI1_YEAST
A:
[44-383]
------------
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
------
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
---------
G
N
V
-
T
Y
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGL----
H
------
Q
-
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
-
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
-
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
--------
K
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
-----
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.20
26%
-97
- C2 -
4GAV
2
NDI1_YEAST
A:
[13-352]
------------
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
------
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
---------
G
N
V
-
T
Y
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGL----
H
------
Q
-
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
-
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
-
V
H
Q
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
--------
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
-----
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
79.73
24%
-91
- C2 -
3ICS
2
?
A:
[35-353]
---------
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
-
R
R
L
S
---
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
-
F
-
A
-
N
C
G
-
L
P
Y
Y
I
G
-
G
V
I
T
-
E
RQ---------
K
-
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
---------
L
D
I
R
V
--
L
-
S
-
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
---------------------
N
VTTN
E
T
Y
-
N
E
A
----
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
-
S
I
P
G
-----
I
E
-
E
AK
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
----------------
E
K
K
P
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
R
---------------
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
GA---------------------
V
---
V
R
L
K
---
S
--------
G
S
V
--------
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
-
A
K
G
A
-----
G
L
A
-
L
G
V
R
G
T
----
I
K
V
N
E
K
F
Q
T
-
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
-
V
--
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.80
26%
-92
- C2 -
4G6H
5
NDI1_YEAST
A:
[44-375]
------------
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
------
N
V
S
I
I
S
P
R
S
Y
F
L
-
F
-
T
-
P
-
L
-
L
P
S
A
P
V
-
G
T
V
D
-
E
-----------
K
-
S
I
I
E
P
I
V
N
F
A
L
K
K
K
---------
G
N
V
-
T
Y
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGL----
H
------
Q
-
A
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
I
P
G
-----
V
T
-
D
--
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
-
L
L
S
I
V
V
V
G
G
G
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
-
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
---
L
L
A
K
---
T
--------
K
H
E
DG
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
-
I
T
D
L
F
K
K
I
P
E
Q
N
-
S
S
K
R
G
-----
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
74.97
17%
-67
- C2 -
1M6I
1
AIFM1_HUMAN
A:
[8-488]
-------A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
-
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
-
P
-
P
-
L
-
S
-
K
E
L
W
F
S
-
P
N
V
T
-
K
TLRFKQWNG
K
E
R
-
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
DLPHIEN
G
G
V
A
V
-
L
--
T
-
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
---------------------
D
------
G
S
Q
I
T
----
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
-
S
A
I
D
R
AG
A
E
V
K
-
S
--
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
V
K
------------------
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
-
A
R
A
-
L
---------
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
-
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
SG
K
L
-------------------
L
---
I
K
L
K
---
D
--------
G
R
K
--------
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
-
E
L
A
K
T
G
-----
G
L
E
I
D
S
D
F
G
G
----
F
R
V
N
A
E
L
Q
A
R
--
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
--
G
--
R
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
------
T
G
A
A
K
P
Y
W
H
----------------------------------------------------------------------------------------
Q
S
M
F
W
S
D
-----
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
--------
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
Y
G
K
G
V
I
F
Y
L
R
D
-----------------------------------------------------
K
V
V
V
G
I
V
L
W
N
I
F
N
R
M
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F
--------------------
36
HHSearch
73.72
24%
-91
- C2 -
3KLJ
1
NROR_CLOAB
A:
[8-293]
---------
K
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
-
L
G
K
-----
C
D
D
I
T
M
I
N
S
E
K
Y
L
P
Y
Y
-
R
-
P
-
R
-
L
N
E
I
I
A
-
K
N
K
S
-
I
-----------
D
-
D
I
L
I
K
K
N
D
W
Y
E
K
N
N
---------
I
K
V
-
I
--
T
-
S
E
F
A
T
S
I
D
P
N
N
K
L
V
T
L
K
S--------------------
G
------
E
-
K
I
K
----
Y
E
K
L
I
I
A
S
G
S
I
A
N
K
I
-
K
V
P
H
-----
A
D
----
E
I
F
S
L
Y
S
Y
D
D
A
L
K
I
K
D
E
C
------------------
K
N
K
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
I
D
S
---------------
G
T
P
A
S
I
G
I
I
L
E
Y
P
L
E
R
Q
-
L
D
R
D
G
G
L
F
L
K
D
K
L
D
R
L
G
I
K
I
Y
T
N
S
N
F
E
E
M
----------------------------------------------
G
D
L
--------
I
R
S
S
C
V
I
T
A
V
G
V
K
P
N
L
D
F
-
I
K
D
T
-----
E
I
A
---
S
K
R
G
----
I
L
V
N
D
H
M
E
T
-
S
I
K
D
I
Y
A
C
G
D
V
A
E
F
Y
G
---------
K
N
P
G
L
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
72.81
21%
-96
- C2 -
1XHC
1
?
A:
[9-301]
-----------
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
-
S
Q
------
T
Y
E
V
T
V
I
D
K
E
P
V
P
Y
-
Y
-
S
K
P
-
M
-
L
S
H
Y
I
A
-
G
F
I
P
-
R
-----------
N
-
R
L
F
P
Y
S
L
D
W
Y
R
K
R
G
---------
I
E
I
-
R
--
L
A
E
-
E
A
K
L
I
D
R
G
R
K
V
V
I
T
E
---------------------
K
------
G
-
E
V
P
----
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
-
Q
I
K
G
-----
K
--
E
--
Y
L
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
------------------
E
N
S
G
E
A
I
I
I
G
G
G
F
I
G
L
E
L
A
G
N
L
A
E
A
---------------
G
Y
H
V
K
L
I
H
R
G
A
M
F
L
--
G
-
L
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
E
E
-----------------------
G
---
V
L
-
T
---
N
--------
S
G
F
--------
I
E
G
K
V
K
I
C
A
I
G
I
V
P
N
V
D
L
-
A
R
R
S
-----
G
I
H
-
T
G
-
R
G
-----
I
L
I
D
D
N
F
R
T
-
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
S
G
---------
I
I
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
71.30
19%
-76
* C2 *
3EF6
9
TODA_PSEP1
A:
[3-336]
-----------
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
-
R
A
E
G
F
---
E
G
R
I
S
L
I
G
D
E
P
H
L
P
-
Y
D
R
-
P
-
S
-
L
S
K
A
V
L
D
G
S
L
E
-
R
-----------
P
-
P
I
L
-
A
E
A
D
W
Y
G
E
A
R
---------
I
D
M
-
L
--
T
G
P
-
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
---------------------
D
G-----
T
-
T
L
S
----
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
-
A
L
P
G
-----
S
Q
L
P
--
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
------------------
T
S
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
L
---------------
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
-
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
G
V
V
G
F
S
G
E
GQLE-------------------
Q
---
V
M
A
S
---
D
--------
G
R
S
--------
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
-
A
R
Q
A
-----
G
L
A
-
C
D
--
R
G
----
V
I
V
D
H
C
G
A
T
-
L
A
K
G
V
F
A
V
G
D
V
A
S
W
P
L
R
-
A
G
-
G
--
R
R
S
L
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
V
S
A
-
P
Q
L
P
V
S
W
T
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
70.33
19%
-92
- C2 -
1NHP
3
NAPE_ENTFA
A:
[1-315]
-----------
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
-
L
N
L
H
---
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
-
F
-
L
-
S
-
A
G
M
Q
L
Y
L
E
-
G
K
V
K
D
V
-----------
N
-
S
V
R
Y
M
T
G
E
K
M
E
S
R
G
---------
V
N
V
-
F
--
S
-
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
DLVSG
E
---------------
E
------
R
-
V
E
N
----
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
-
D
I
P
G
-----
K
D
L
D
--
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
----------------
D
P
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
A
---------------
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
-
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
-----------------------
G
RVQ
K
V
V
T
---
D
--------
K
N
A
--------
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
-
A
-
W
L
K
G
-----
T
L
E
-
L
H
P
N
G
L
----
I
K
T
D
E
Y
M
R
T
-
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
-
P
AD
T
--
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
70.11
19%
-88
- C2 -
2GQW
5
?
A:
[6-308]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
-
R
Q
A
G
Y
---
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
-
Y
-
D
R
P
-
P
-
L
S
K
D
F
M
-
A
H
G
D
-
A
-----------
E
-
K
I
R
L
D
---
C
K
R
A
P
E
---------
V
E
W
-
L
--
L
-
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D--------------------
G
------
R
-
T
L
P
----
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
-----
A
T
-
M
--
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
------------------
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
---------------
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
-
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
---
V
L
L
D
---
D
--------
G
T
R
--------
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
-
A
L
A
R
A
A
-----
G
L
A
-
C
--
D
D
G
----
I
F
V
D
A
Y
G
R
T
-
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
-
L
S-
G
R-
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
69.17
21%
-88
- C2 -
3CGB
2
?
A:
[37-353]
-----------
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
-
V
R
N
D
---
E
N
A
N
V
V
T
L
E
K
G
E
I
Y
S
-
Y
A
Q
-
C
-
G
-
L
P
Y
V
I
S
-
G
A
I
A
-
S
TE---------
K
-
L
I
A
R
N
V
K
T
F
R
D
K
Y
G
---------
I
D
A
K
V
--
R
-
H
-
E
V
T
K
V
D
T
E
K
K
I
V
Y
A
E
HTKTK
D
---------------
V
------
F
-
E
F
S
----
Y
D
R
L
L
I
A
T
G
V
R
P
V
M
P
-
E
W
E
G
-----
R
D
-
L
Q-
G
V
H
L
L
K
T
I
P
D
A
E
R
I
L
K
T
L
E
----------------
T
N
K
V
E
D
V
T
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
V
E
L
---------------
G
K
K
V
R
M
I
E
R
N
D
H
I
G
T
-
I
-
Y
D
G
D
M
A
E
Y
I
Y
K
E
A
D
K
H
H
I
E
I
L
T
N
E
N
V
K
A
F
K
G
N
-----------------------
E
RVE
A
V
E
T
---
D
--------
K
G
T
--------
Y
K
A
D
L
V
L
V
S
V
G
V
K
P
N
T
D
F
-
L
E
G
T
-----
N
I
R
-
T
N
H
K
G
A
----
I
E
V
N
A
Y
M
Q
T
-
N
V
Q
D
V
Y
A
A
G
D
C
A
T
H
Y
H
V
-
I
--
K
E
I
H
D
H
I
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------