@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2676: (2016-04-06 )
VRHVVIFCASILNRFFASVECVKRRLNPLEAYLVVMSNAERAGGLVLAATPKMKQEHHIKTGSRMYELPTWDKRIIIAPPRMKLYLKVNAMIQAIFRRYVPAEFIHVYSIDECFLDVTGSHLLFGSTEEIVRKIQRDILEELRLYVTVGIGDNPLLAKLALDNVAKNRDDGIAEWRYEHVPETIWKIRHLDDVCGIGRRTAVRLQKMGIFNMYQLSQTPPQVLKNVMGVVGEQLYYHAHGIDYSLLNEKYVPVSKSYGKSQILEKDYHVPAEVEIVIREMVEEVAMRLRQNHVDTAVIHLSVGYSKYSIKKGFSHQAKIPPTSSSHALIPYFLQLFRRYDEREPVRSIAISCGKITLKTGLQLNLFEDFTQTLNHEQLEITVDKIRSRYGFKSLMHASSLLNGATGLKRSEMVGGHKG
Atome Classification :
(20 SA)
------------------------------------------------------------------.........10........20........----30........40------------------------------........50--........60........70........80........90.-.......100.......110.......120.--------------------..-....130.......140.......150.......160-.......170.......180.......190-........200.......210.......220...-....-230.......240.......250........260-.......270.......280.......290----........300......------------.310.......320........330.......340.--.......350.......360.......370.......380.......390.......400.......410......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------V
R
H
V
V
I
F
C
A
S
I
L
N
R
F
F
A
S
V
E
C
V
K
R
RL
N
P
L
----
E
A
Y
L
V
VMSNAER------------------------------AG
G
L
V
L
AATP--KM
K
Q
E
HHIKTG
S
R
M
YELPTWD
K
R
I
I
IAPP
R
M
K
L
Y
L
K
V
N
A
M
I
-
Q
A
I
F
R
RYV
P
A
E
F
I
H
V
Y
S
I
D
E
C
F
L
DVTGSHLL--------------------FG-
S
T
E
E
I
V
R
K
I
Q
R
D
I
L
E
E
L
R
L
Y
V
T
V
GIGDN
P
L
L
A
K
L
A
L
D
-
N
VAKNRDD
G
I
A
E
W
R
Y
E
HV
P
E
T
I
W
K
I
RH
L
D
--
D
V
CGIG
R
R
T
A
V
R
L
Q
K
MGI
F
N
M
Y
QLSQT
P
P
Q
V
L
K
N
-
V
M
G
V
-
V
G
E
Q
L
Y
Y
H
AHGI
D
Y
S
L
LNEKY-VPVSKSYGK
S
Q
I
-
L
E
KDYHVP
A
E
V
E
I
V
I
R
E
M
V
E
E
V
A
M
R
L
R
QN-----HV
D
T
A
V
I
H
L
S
VGY
S
K
Y
S
------------IKKGFSHQAKIPP-TSSSH
A
L
I
P
Y
F
L
Q
L
F
R
R
YDE-R--E
P
V
R
S
I
A
ISCG
K
I
T
L
KTG
L
Q
L
N
L
F
E
D
F
T
Q
TLN
H
E
Q
L
E
I
T
V
D
K
I
R
S
R
YG
F
K
S
L
M
H
A
S
S
L
LNGATGL
K
R
S
E
MVGGHKG
16
PsiBlast_PDB
90.46
26%
-132
- C2 -
2ASD
7
DPO4_SULSO
A:
[10-349]
---------------------------------------------------------------------
I
V
L
F
V
D
--
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
LKG
K
P
V
V
V
C
V
F
S
G
R
F
E
------------------------------
D
S
G
A
V
A
T
A
N
Y
--
E
A
R
K
-
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
-
M
A
K
P
N
---
G
I
K
V
I
D
D
E
E
V
K
R
L
---
I
R
E
L
D
IA
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
-
L
K
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
-
M
K
R
N
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
IPK
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
------------
F
P
H
G
I
S
K
E
------
T
A
Y
S
E
S
V
--
K
L
L
Q
K
I
L
E
E
D
E
-
R
--
K
-
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------
19
PsiBlast_PDB
89.93
26%
-132
- C2 -
2ATL
6
DPO4_SULSO
A:
[10-349]
---------------------------------------------------------------------
I
V
L
F
V
D
--
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
LKG
K
P
V
V
V
C
V
F
S
G
R
F
E
------------------------------
D
S
G
A
V
A
T
A
N
Y
--
E
A
R
K
-
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
-
M
A
K
P
N
---
G
I
K
V
I
D
D
E
E
V
K
R
L
---
I
R
E
L
D
IA
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
-
L
K
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
-
M
K
R
N
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
IPK
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
------------
F
P
H
G
I
S
K
E
------
T
A
Y
S
E
S
V
--
K
L
L
Q
K
I
L
E
E
D
E
-
R
--
K
-
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------
18
PsiBlast_PDB
89.52
26%
-130
- C2 -
2ASL
3
DPO4_SULSO
A:
[10-349]
---------------------------------------------------------------------
I
V
L
F
V
D
--
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
LKG
K
P
V
V
V
C
V
F
S
G
R
F
E
------------------------------
D
S
G
A
V
A
T
A
N
Y
--
E
A
R
K
-
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
-
M
A
K
P
N
---
G
I
K
V
I
D
D
E
E
V
K
R
L
---
I
R
E
L
D
IA
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
-
L
K
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
-
M
K
R
N
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
IPK
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
------------
F
P
H
G
I
S
K
E
------
T
A
Y
S
E
S
V
--
K
L
L
Q
K
I
L
E
E
D
E
-
R
--
K
-
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------
20
PsiBlast_PDB
88.84
26%
-124
- C2 -
2AU0
3
DPO4_SULSO
A:
[10-349]
---------------------------------------------------------------------
I
V
L
F
V
D
--
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
LKG
K
P
V
V
V
C
V
F
S
G
R
F
E
------------------------------
D
S
G
A
V
A
T
A
N
Y
--
E
A
R
K
-
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
-
M
A
K
P
N
---
G
I
K
V
I
D
D
E
E
V
K
R
L
---
I
R
E
L
D
IA
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
-
L
K
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
-
M
K
R
N
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
IPK
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
------------
F
P
H
G
I
S
K
E
------
T
A
Y
S
E
S
V
--
K
L
L
Q
K
I
L
E
E
D
E
-
R
--
K
-
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------
17
PsiBlast_PDB
87.77
26%
-126
- C2 -
2ASJ
3
DPO4_SULSO
A:
[10-349]
---------------------------------------------------------------------
I
V
L
F
V
D
--
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
LKG
K
P
V
V
V
C
V
F
S
G
R
F
E
------------------------------
D
S
G
A
V
A
T
A
N
Y
--
E
A
R
K
-
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
-
M
A
K
P
N
---
G
I
K
V
I
D
D
E
E
V
K
R
L
---
I
R
E
L
D
IA
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
-
L
K
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
-
M
K
R
N
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
IPK
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
------------
F
P
H
G
I
S
K
E
------
T
A
Y
S
E
S
V
--
K
L
L
Q
K
I
L
E
E
D
E
-
R
--
K
-
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------
11
PsiBlast_PDB
86.61
26%
-130
- C- -
2UVR
6
DPO4_SULSO
A:
[8-348]
---------------------------------------------------------------------
I
V
L
F
V
D
--
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
LKG
K
P
V
V
V
C
V
F
S
G
R
F
E
------------------------------
D
S
G
A
V
A
T
A
N
Y
--
E
A
R
K
-
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
-
M
A
K
P
N
---
G
I
K
V
I
D
D
E
E
V
K
R
L
---
I
R
E
L
D
IA
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
-
L
K
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
-
M
K
R
N
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
IPK
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
------------
F
P
H
G
I
S
K
E
------
T
A
Y
S
E
S
V
--
K
L
L
Q
K
I
L
E
E
D
E
-
R
--
K
-
I
R
A
I
G
V
R
F
S
K
F
I
E
-------------------------------------------------------------
14
PsiBlast_PDB
86.24
26%
-129
- C- -
2UVW
6
DPO4_SULSO
A:
[8-348]
---------------------------------------------------------------------
I
V
L
F
V
D
--
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
S
LKG
K
P
V
V
V
C
V
F
S
G
R
F
E
------------------------------
D
S
G
A
V
A
T
A
N
Y
--
E
A
R
K
-
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
-
M
A
K
P
N
---
G
I
K
V
I
D
D
E
E
V
K
R
L
---
I
R
E
L
D
IA
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
-
L
K
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
-
M
K
R
N
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
IPK
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
------------
F
P
H
G
I
S
K
E
------
T
A
Y
S
E
S
V
--
K
L
L
Q
K
I
L
E
E
D
E
-
R
--
K
-
I
R
E
I
G
V
R
F
S
K
F
I
E
-------------------------------------------------------------
9
PsiBlast_PDB
84.55
27%
-106
- C2 -
4Q45
5
DPO4_ECOLI
F:
[10-281]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
AR
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
--------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
84.45
22%
-121
* C2 *
1JX4
5
DPO4_SULSO
A:
[2-341]
-----------------------------------------------------------------------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
----
K
P
V
V
V
C
V
F
S
G
R
F
------------------------------
E
D
S
G
A
V
A
T
A
N
--
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
-
L
L
R
E
Y
S
E
K
--
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------
Y
R
-
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
----
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
-
I
A
--
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
-
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
----
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
-
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
-----
I
P
K
A
I
H
V
V
A
V
T
-----
E
------------
D
L
D
I
V
S
R
G
R
T
F
P
H
-
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
-
E
D
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
--------------------------------------------------------------
2
PsiBlast_PDB
84.44
27%
-109
- C2 -
4IR1
5
DPO4_ECOLI
F:
[10-289]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
AR
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
L
L
I
A
R
Q
G
V
------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
84.41
19%
-111
- C2 -
3GQC
-
REV1_HUMAN
A:
[416-828]
--------------------------------------------------------------------
Q
S
C
I
M
H
V
D
-
M
D
C
F
F
V
S
V
G
I
R
N
R
P
D
L
-
K
----
G
K
P
V
A
V
T
S
N
R
G
T
GRAPLRPGAN
P
Q
L
E
W
Q
Y
Y
Q
N
KILKGIDSVL
S
R
A
E
I
A
S
C
S
Y
--
E
A
R
-
Q
L
G
I
K
N
G
M
F
F
G
H
A
K
Q
L
C
P
N
L
Q
A
V
P
Y
D
F
H
A
Y
K
E
V
A
Q
T
L
-
Y
E
T
L
A
S
Y
T
H
N
I
--
E
A
V
S
C
D
E
A
L
V
D
I
T
E
I
L
A
E
--------------------
T
K
L
T
P
D
E
F
A
N
A
V
R
M
E
I
K
D
Q
T
K
C
A
A
S
V
G
I
G
S
N
I
L
L
A
R
M
A
T
R
-
K
A
---
K
P
D
G
Q
Y
H
L
K
P
E
E
V
D
D
F
I
R
G
Q
-
L
V
T
--
N
L
P
G
V
G
H
S
M
E
S
K
L
A
S
L
G
I
K
T
C
G
D
L
Q
Y
M
T
M
A
K
L
Q
K
-
E
F
G
P
K
T
G
Q
M
L
Y
R
F
C
R
G
L
D
D
R
P
V
R
T
E
K
---
E
R
K
S
V
S
A
E
I
N
-
Y
G
I
R
F
T
Q
P
K
E
A
E
A
F
L
L
S
L
S
E
E
I
Q
R
R
L
E
A
T
-----
G
M
K
G
K
R
L
T
L
K
I
M
V
R
K
P
G
APVETAKFGGH
G
I
C
D
N
I
A
R
T
V
T
L
D
Q
A
T
D
N
A
K
I
I
G
K
A
M
L
N
M
F
H
T
M
K
L
N
I
--
S
D
M
R
G
V
G
I
H
V
N
Q
L
V
P
T
N
-----------------------------------------------------------
6
PsiBlast_PDB
84.02
27%
-111
- C2 -
4IRD
5
DPO4_ECOLI
F:
[10-281]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
AR
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
--------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.74
27%
-115
- C2 -
4IRK
5
DPO4_ECOLI
B:
[10-281]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
AR
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
--------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.70
27%
-111
- C2 -
4R8U
4
?
B:
[8-279]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
--------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.52
27%
-109
- C2 -
4IR9
5
DPO4_ECOLI
F:
[10-289]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
AR
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
L
L
I
A
R
Q
G
V
------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
83.26
17%
-115
- C2 -
2W7O
5
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
RN
L
S
N
T
I
V
H
I
--
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
--
E
L
----
K
D
K
P
I
A
V
G
S
M
----------------------------------
S
M
L
S
T
S
N
Y
--
H
A
R
R
-
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
-
K
E
I
L
A
D
Y
D
P
--
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
R
Q
NWPEDKRRYFIKQN
S
V
V
F
G
T
-
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
-
K
N
K
P
N
G
Q
Y
Q
I
L
P
-
N
R
Q
A
V
M
D
F
I
K
D
L
P
-
I
R
--
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
-
F
S
E
T
-
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
-
E
R
K
S
M
S
V
E
R
T
F
S
-
E
I
N
K
---
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
-----
R
L
K
G
R
T
V
T
I
K
L
K
N
V
N
F
E
------------
V
K
T
R
A
S
T
V
S
S
V
V
---
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
-
A
--
D
F
P
H
P
L
R
L
R
L
M
G
V
R
I
S
-----------------------------------------------
S
F
P
N
E
--------
8
PsiBlast_PDB
83.06
27%
-113
- C2 -
4Q44
6
DPO4_ECOLI
A:
[10-281]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
--------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
83.03
16%
-110
- C2 -
2OH2
4
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
RN
L
S
N
T
I
V
H
I
--
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
----
K
P
I
A
V
------
G
------------------------------
S
M
S
M
L
S
T
S
N
Y
--
H
A
R
R
-
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
-
K
E
I
L
A
D
Y
D
P
--
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
R
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
-
G
T
-
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
-
K
-
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
P
-
I
R
--
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
-
F
S
E
T
-
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
---
G
E
R
K
S
M
S
V
E
R
T
-
F
S
E
I
N
K
-
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
-----
R
L
K
G
R
T
V
T
I
K
L
K
N
V
N
F
E
------------
V
K
T
--
R
A
S
T
V
S
S
V
-
V
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
-
A
--
D
F
P
H
P
L
R
L
R
L
M
G
V
R
I
S
-------------------------------
S
F
P
--------------------------
5
PsiBlast_PDB
83.02
27%
-108
- C2 -
4IRC
5
DPO4_ECOLI
F:
[10-281]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
AR
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
--------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.79
27%
-114
- C2 -
4Q43
7
DPO4_ECOLI
A:
[10-289]
-----------------------------------------------------------------------------
M
D
C
F
F
A
A
V
E
M
---
R
D
N
P
A
LR--
D
I
P
I
A
I
G
G
S
R
E
R
------------------------------
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
----
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
-
R
E
I
F
S
R
Y
T
--
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------
H
G
-
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
----
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
--
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
-
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
---
L
R
K
S
V
G
V
E
R
T
-
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-----
K
P
D
L
L
I
A
R
Q
G
V
------------------------------------------------------------------------------------------------------------------------------------