@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2684: (2016-04-06 )
MNGFIAFMEKYFIPYAAKIGGQRHLVAIRDGFITTMPLMILGSFAVLINNFPIPAYQKFMNNLFGEGTWQAFGGNVWNGTFAILALLIAFTVAYNLAKSYDKDPLSSAVVSVATFFTIGAIAPGADGIANTGGLGSTGLFLALIIAILSTEIFTRLSGSPKLIINMPDGVPPAVSRSFAALFPAMITVSIFGLITAFFQAAGVTNLVISFYELVQEPFMGLANSLPAALLLAFVSAFLWFFGLHGANIIDPFMQTINIPAIEANVKALEAGKELPYIVNKPFFDSFVNLGGTGATIGLIIAIFIVARKHKAYMTVSKLSAAPGIFNINEPMMFGLPIVLNPIMFIPYILAPLVLVTVAYFATAIGWVPACTIVTPWTTPPIIGGALATQSIAGGVLAAVNLGLSILIFLPFAKIAQIQELRREKEALAAEGVTAE
Atome Classification :
(20 SA)
-.........-10.--.......20........30.........40..----......50........60........70........80........90........100........110...-----..-----..120-.---..-------....130.------......140.......150..---.....160.......170-----.........180-----.......-------.190-.......200.......210....------...220.......230...-....240.......250.-------------------------------------......----------260.....-..270------........280---.......290.......300.......310.......320.......330....-...340.......350-..------....-.360.....--..370........380......-.-390-.......400---------.......410---...-...-...420.......430...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MN
G
F
I
A
F
M
E
-
K
Y
F--
I
P
Y
A
A
KIGG
Q
R
H
L
V
A
IRD-G
F
I
T
T
M
P
L
M
I
L
G
S
----
F
A
V
L
INNFP
I
P
A
Y
Q
K
F
M
N
N
L
FGEGT
W
Q
AFGGNVW
N
G
T
F
A
I
L
A
L
L
I
A
F
T
V
A
Y
N
L
A
K
SY-DKD
P
L
S
S
A
V
V
S
V
A
T
F
-----
F
T-----IGAIA-P---GA-------DGIANTGG------LG
S
T
G
L
F
L
A
L
I
I
A
I
L
S
T
E
I
F
T
---RLSGS
P
K
L
I
I
NMPDGV-------
P
P
A
V
S
R
S
F
A
A
L
------
F
P
A
M
I
T
V
-------
S
I
F
G
-
L
I
T
A
F
F
Q
AAG
V
T
N
L
V
I
S
F
Y
E
L
V
Q
E
------
P
F
M
G
L
A
N
S
L
P
A
A
L
L
L
A
F
V
S
-
A
F
L
W
F
F
GLHG
A
N
I
I
D
P
F
M
-------------------------------------
Q
TINIP----------AIEA
N
V
K
A
-
L
EA-G------KELP
Y
I
VN
K
P
F
---
F
D
S
F
V
NLGGT
G
A
T
I
G
L
I
I
A
I
F
I
V
ARK
H
K
A
Y
M
T
V
S
K
LSAAPGIFNINEP
M
M
FG
L
P
-
I
V
L
N
P
I
M
F
I
P
Y
I
L
A
P
L
-
V
L
------
V
T
V
A
-
Y
F
A
T
A
IGWV--
P
A
C
T
-
I
VTPWTTPPII
G
G
A
L
A
T
-
Q
-
S
IA-
G
G
V
L
A
A
V
N
LG---------
L
S
I
L
I
F
LP-----
F
A
K
-
I
A
Q
-
I
Q
E
L
R
R
E
K
E
A
L
AAEGVTAE
8
PsiBlast_CBE
89.48
41%
-133
- C2 -
3QNQ
7
?
B:
[3-427]
------
R
F
L
E
-
K
Y
V
--
M
P
V
A
G
K
V
A
E
Q
R
H
L
L
A
I
R
D
-
G
L
V
L
T
M
P
F
L
I
I
G
S
----
I
F
L
I
I
S
T
L
P
I
P
G
Y
S
E
F
M
A
S
L
F
G
K
-
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
V
F
G
I
A
Y
R
L
G
E
Y
Y
-
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
LLATP
F
Q
-----
V
A
Y
I
M
-
P
---
G
T
KESILV-
D
G
V
I
P
A
A
L
------
M
G
S
Q
G
L
F
V
A
M
I
I
A
I
I
S
T
E
I
Y
----
R
F
L
V
Q
K
K
M
I
I
K
M
P
E
T
V
-------
P
P
A
V
T
R
S
F
A
A
L
------
I
P
G
F
I
V
V
-------
T
V
V
W
-
I
I
R
L
I
F
E
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
------
P
L
S
I
L
G
A
S
L
W
G
A
V
I
A
V
I
L
V
-
H
V
L
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-------------------------------------
S
P
I
W
L
S
----------
L
M
D
Q
N
R
I
A
-
F
Q
A
-
G
------
Q
D
V
P
N
T
I
T
A
Q
F
---
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
-
L
K
S
L
G
R
L
S
I
A
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
-
I
V
M
N
P
L
L
L
I
P
F
I
V
V
P
V
-
V
L
------
T
I
V
S
-
Y
F
A
M
E
W
G
L
V
AR
P
S
G
A
-
A
V
T
-
W
T
T
P
I
L
F
S
G
Y
L
G
S
G
G
-
K
I
S
-
G
V
I
L
Q
L
V
N
F
A
---------
L
A
F
V
I
Y
L
P
-----
F
L
K
-
I
W
D
-
K
Q
K
I
---------------
1
PsiBlast_PDB
89.33
41%
-137
- C2 -
3QNQ
8
?
A:
[3-427]
------
R
F
L
E
-
K
Y
V
--
M
P
V
A
G
K
V
A
E
Q
R
H
L
L
A
I
R
D
-
G
L
V
L
T
M
P
F
L
I
I
G
S
----
I
F
L
I
I
S
T
L
P
I
P
G
Y
S
E
F
M
A
S
L
F
G
K
-
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
V
F
G
I
A
Y
R
L
G
E
Y
Y
-
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
L
L
A
T
P
F
Q
-----
V
A
Y
I
M
-
P
---
G
T
K
E
S
I
L
V
-
D
G
V
I
P
A
A
L
------
M
G
S
Q
G
L
F
V
A
M
I
I
A
I
I
S
T
E
I
Y
----
R
F
L
V
Q
K
K
M
I
I
K
M
P
E
T
V
-------
P
P
A
V
T
R
S
F
A
A
L
------
I
P
G
F
I
V
V
-------
T
V
V
W
-
I
I
R
L
I
F
E
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
------
P
L
S
I
L
G
A
S
L
W
G
A
V
I
A
V
I
L
V
-
H
V
L
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-------------------------------------
S
P
I
W
L
S
----------
L
M
D
Q
N
R
I
A
-
F
Q
A
-
G
------
Q
D
V
P
N
T
I
T
A
Q
F
---
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
-
L
K
S
L
G
R
L
S
I
A
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
-
I
V
M
N
P
L
L
L
I
P
F
I
V
V
P
V
-
V
L
------
T
I
V
S
-
Y
F
A
M
E
W
G
L
V
AR
P
S
G
A
-
A
V
T
-
W
T
T
P
I
L
F
S
G
Y
L
G
S
G
G
-
K
I
S
-
G
V
I
L
Q
L
V
N
F
A
---------
L
A
F
V
I
Y
L
P
-----
F
L
K
-
I
W
D
-
K
Q
K
I
---------------
6
PsiBlast_CBE
89.21
41%
-138
- C2 -
3QNQ
7
?
D:
[3-427]
------
R
F
L
E
-
K
Y
V
--
M
P
V
A
G
K
V
A
E
Q
R
H
L
L
A
I
R
D
-
G
L
V
L
T
M
P
F
L
I
I
G
S
----
I
F
L
I
I
S
T
L
P
I
P
G
Y
S
E
F
M
A
S
L
F
G
K
-
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
V
F
G
I
A
Y
R
L
G
E
Y
Y
-
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
LLATP
F
Q
-----
V
A
Y
I
M
-
P
---
G
T
KESILV-
D
G
V
I
P
A
A
L
------
M
G
S
Q
G
L
F
V
A
M
I
I
A
I
I
S
T
E
I
Y
----
R
F
L
V
Q
K
K
M
I
I
K
M
P
E
T
V
-------
P
P
A
V
T
R
S
F
A
A
L
------
I
P
G
F
I
V
V
-------
T
V
V
W
-
I
I
R
L
I
F
E
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
------
P
L
S
I
L
G
A
S
L
W
G
A
V
I
A
V
I
L
V
-
H
V
L
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-------------------------------------
S
P
I
W
L
S
----------
L
M
D
Q
N
R
I
A
-
F
Q
A
-
G
------
Q
D
V
P
N
T
I
T
A
Q
F
---
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
-
L
K
S
L
G
R
L
S
I
A
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
-
I
V
M
N
P
L
L
L
I
P
F
I
V
V
P
V
-
V
L
------
T
I
V
S
-
Y
F
A
M
E
W
G
L
V
AR
P
S
G
A
-
A
V
T
-
W
T
T
P
I
L
F
S
G
Y
L
G
S
G
G
-
K
I
S
-
G
V
I
L
Q
L
V
N
F
A
---------
L
A
F
V
I
Y
L
P
-----
F
L
K
-
I
W
D
-
K
Q
K
I
---------------
7
PsiBlast_CBE
89.20
41%
-136
- C2 -
3QNQ
9
?
C:
[3-427]
------
R
F
L
E
-
K
Y
V
--
M
P
V
A
G
K
V
A
E
Q
R
H
L
L
A
I
R
D
-
G
L
V
L
T
M
P
F
L
I
I
G
S
----
I
F
L
I
I
S
T
L
P
I
P
G
Y
S
E
F
M
A
S
L
F
G
K
-
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
V
F
G
I
A
Y
R
L
G
E
Y
Y
-
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
LLATP
F
Q
-----
V
A
Y
I
M
-
P
---
G
T
KESILV-
D
G
V
I
P
A
A
L
------
M
G
S
Q
G
L
F
V
A
M
I
I
A
I
I
S
T
E
I
Y
----
R
F
L
V
Q
K
K
M
I
I
K
M
P
E
T
V
-------
P
P
A
V
T
R
S
F
A
A
L
------
I
P
G
F
I
V
V
-------
T
V
V
W
-
I
I
R
L
I
F
E
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
------
P
L
S
I
L
G
A
S
L
W
G
A
V
I
A
V
I
L
V
-
H
V
L
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-------------------------------------
S
P
I
W
L
S
----------
L
M
D
Q
N
R
I
A
-
F
Q
A
-
G
------
Q
D
V
P
N
T
I
T
A
Q
F
---
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
-
L
K
S
L
G
R
L
S
I
A
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
-
I
V
M
N
P
L
L
L
I
P
F
I
V
V
P
V
-
V
L
------
T
I
V
S
-
Y
F
A
M
E
W
G
L
V
AR
P
S
G
A
-
A
V
T
-
W
T
T
P
I
L
F
S
G
Y
L
G
S
G
G
-
K
I
S
-
G
V
I
L
Q
L
V
N
F
A
---------
L
A
F
V
I
Y
L
P
-----
F
L
K
-
I
W
D
-
K
Q
K
I
---------------
9
HHSearch
88.98
41%
-136
- C2 -
3QNQ
8
?
A:
[3-434]
------
R
F
L
E
-
K
Y
V
--
M
P
V
A
G
K
V
A
E
Q
R
H
L
L
A
I
R
D
-
G
L
V
L
T
M
P
F
L
I
I
G
S
----
I
F
L
I
I
S
T
L
P
I
P
G
Y
S
E
F
M
A
S
L
F
G
-
K
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
V
F
G
I
A
Y
R
L
G
E
Y
Y
-
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
-----
L
L
-----
A
T
P
F
Q
V
A
Y
I
M
P
G
TK
E
S
I
L
V
D
G
V
I
P
A
A
L
------
M
G
S
Q
G
L
F
V
A
M
I
I
A
I
I
S
T
E
I
Y
R
---
F
L
V
Q
-
K
K
M
I
I
K
M
P
E
T
V
-------
P
P
A
V
T
R
S
F
A
A
L
------
I
P
G
F
I
V
V
-------
T
V
V
W
-
I
I
R
L
I
F
E
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
------
P
L
S
I
L
G
A
S
L
W
G
A
V
I
A
V
I
L
V
-
H
V
L
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-------------------------------------
S
P
I
W
L
S
----------
L
M
D
Q
N
R
I
A
-
F
Q
A
-
G
------
Q
D
V
P
N
T
I
T
A
Q
F
---
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
-
Q
Q
L
K
S
L
G
R
L
S
I
A
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
-
I
V
M
N
P
L
L
L
I
P
F
I
V
V
P
V
-
V
L
------
T
I
V
S
-
Y
F
A
M
E
W
G
L
V
--
A
R
P
S
G
A
A
V
T
W
T
T
P
I
L
F
S
G
Y
L
G
S
-
G
G
K
I
S
-
G
V
I
L
Q
L
V
N
F
A
---------
L
A
F
V
I
Y
L
P
-----
F
L
K
-
I
W
D
-
K
Q
K
I
A
E
E
K
G
E
A
--------
16
Fugue
88.55
41%
-139
- C2 -
3QNQ
8
?
A:
[3-434]
------
R
F
L
E
-
K
Y
V
--
M
P
V
A
G
K
V
A
E
Q
R
H
L
L
A
I
R
D
-
G
L
V
L
T
M
P
F
L
I
I
G
S
----
I
F
L
I
I
S
T
L
P
I
P
G
Y
S
E
F
M
A
S
L
F
G
K
N
-
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
V
F
G
I
A
Y
R
L
G
E
Y
Y
-
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
-----
L
L
A
T
PF
Q
V
A
Y
I
M
-
P
---
G
T
-------
K
E
S
I
L
V
D
G
VIP
A
A
L
M
G
S
Q
G
L
F
V
A
M
I
I
A
I
I
S
T
E
I
Y
R
---
F
L
V
Q
-
K
K
M
I
I
K
M
P
E
T
V
-------
P
P
A
V
T
R
S
F
A
A
L
------
I
P
G
F
I
V
V
-------
T
V
V
W
-
I
I
R
L
I
F
E
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
------
P
L
S
I
L
G
A
S
L
W
G
A
V
I
A
V
I
L
V
-
H
V
L
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-------------------------------------
S
P
I
W
L
S
----------
L
M
D
Q
N
R
I
A
-
F
Q
A
-
G
------
Q
D
V
P
N
T
I
T
A
Q
F
---
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
-
R
S
Q
Q
L
K
S
L
G
R
L
S
I
A
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
-
I
V
M
N
P
L
L
L
I
P
F
I
V
V
P
V
-
V
L
------
T
I
V
S
-
Y
F
A
M
E
W
G
L
V
--
A
R
P
S
G
A
A
V
T
W
T
T
P
I
L
F
S
G
Y
L
G
S
-
G
G
K
I
S
-
G
V
I
L
Q
L
V
N
F
A
---------
L
A
F
V
I
Y
L
P
-----
F
L
K
-
I
W
D
-
K
Q
K
I
A
E
E
K
G
E
A
--------
23
Fugue
51.90
14%
-130
- C3 -
4C0E
-
?
A:
[9-528]
-
L
E
A
A
H
L
L
E
Q
M
E
Y
V
--
F
D
E
W
I
H
L
C
N
N
P
H
A
T
E
R
A
A
M
I
F
V
H
Q
L
H
S
V
Q
L
V
T
N
R
D
E
F
L
L
F
L
R
H
A
L
D
K
S
V
E
R
F
E
Q
G
I
H
S
G
A
S
I
A
E
S
----
F
Q
A
V
E
A
L
V
K
L
I
I
I
F
V
K
S
H
S
A
A
V
A
F
M
D
------------
S
I
-----
L
A
-----
L
G
V
L
V
-
A
---
N
S
-------
H
H
V
K
R
G
E
N
------
F
N
Q
R
V
F
Y
R
F
F
A
L
L
L
H
E
V
G
L
L
A
GHF
S
K
S
H
Y
E
Q
I
I
L
N
F
A
A
R
L
F
D
M
RPNL
L
P
G
F
A
C
A
W
A
G
L
V
S
HRAF
L
P
V
I
L
G
L
PDEKG
W
A
P
F
T
K
-
L
L
E
Q
F
L
G
C
V
G
E
L
V
K
T
F
T
V
S
S
L
G
K
E
M
Y
H
A
A
L
K
I
L
I
V
L
Q
H
D
F
P
I
Y
L
D
K
F
R
V
-
Q
L
C
Q
S
L
P
L
H
A
T
Q
L
V
N
L
I
L
A
AIPPNCNSLADPFQAGLKVDKIPDMK
E
R
P
P
T
AFD
S
A
G
L
L
R
E
A
----------
G
L
L
D
I
L
E
R
M
L
Q
N
-
G
PS
E
D
G
V
A
Q
I
N
H
A
I
N
K
S
T
---
S
F
G
Y
V
P
L
G
V
N
R
R
L
I
D
A
V
V
A
R
F
A
E
F
A
I
N
R
A
S
S
-----
R
S
D
S
A
I
F
V
A
G
A
N
D
I
K
T
L
Q
M
L
V
T
E
V
S
P
E
A
R
Y
Y
L
V
S
S
M
V
N
E
LRYPN
A
Y
T
N
-
Y
F
S
Q
A
L
L
D
I
--
F
G
H
D
M
S
D
P
E
E
N
L
V
R
E
Q
I
V
R
V
L
L
-
E
-
R
V
L
-
G
Y
W
P
Q
P
W
G
L
I
---------
I
T
I
L
E
L
L
K
NDKYL
F
F
E
-
L
P
F
-
I
K
A
T
P
E
V
A
E
R
F
T
A
L
A
R
S
A
A
24
Fugue
50.31
15%
-113
- C3 -
4BWZ
2
?
A:
[3-386]
---
G
A
E
H
L
L
E
-
I
F
Y
--
L
L
L
A
A
Q
V
C
A
F
I
F
K
---
R
L
-
N
Q
P
V
V
I
G
E
V
L
A
G
V
----
L
V
-------
G
P
A
L
L
G
L
V
H
E
-----------
G
E
I
L
E
F
L
A
E
L
G
A
V
F
L
L
F
M
V
G
L
E
-
T
R
L
K
-
D
I
L
A
V
G
K
E
A
F
L
V
A
V
L
-----
G
V
-----
A
L
P
F
L
-
G
---
G
Y
-------
L
Y
G
L
E
I
G
F
------
E
T
L
P
A
L
F
L
G
T
A
L
V
A
T
S
V
G
I
T
A
---
R
V
L
Q
E
L
G
V
L
------------------
S
R
P
Y
S
R
I
---------
I
L
G
A
-------
A
V
I
D
-
D
V
L
G
L
I
V
L
A
C
V
N
G
V
A
E
T
G
Q
V
E
V
G
A
------
I
T
R
L
I
V
L
S
V
V
F
V
G
L
A
V
F
L
S
-
T
L
I
------------
A
R
L
-------------------------------------
P
L
E
R
L
P
----------
V
G
S
P
L
G
F
A
-
L
A
L
-
G
------
V
G
M
A
A
L
A
A
S
I
------------
G
L
A
P
I
V
G
A
F
L
G
G
M
L
L
S
E
V
R
E
K
Y
R
L
E
E
P
I
F
A
I
E
S
F
L
A
P
I
F
F
A
M
V
G
V
R
-
L
E
L
S
A
L
A
S
P
V
V
L
V
A
G
T
-
V
V
------
T
V
I
A
-
I
L
G
K
V
L
G
G
F
--
L
G
A
--
L
T
Q
G
V
R
S
A
L
T
V
G
C
G
M
A
P
-
R
-
G
E
V
-
G
L
I
V
A
A
L
G
L
K
A
GAVN
E
E
E
Y
A
I
V
L
F
M
V
V
-----
F
T
T
-
L
F
A
-
P
F
A
L
K
P
L
I
A
W
T
E
R
E
R
A
A
K
E
21
Fugue
50.06
14%
-123
- C3 -
3ZPJ
-
?
A:
[1-356]
-
M
T
T
L
E
E
I
N
L
-
L
V
E
--
R
G
Y
Y
E
E
A
--
L
A
K
V
Y
E
I
E
D
----
P
I
E
Q
V
Q
V
L
T
K
----
I
V
V
T
I
Y
Q
H
D
G
P
--
M
E
W
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
L
R
-
D
P
A
N
K
A
V
A
Y
S
I
I
A
S
T
L
A
I
---
M
E
Y
-
E
E
D
A
M
D
F
F
N
R
A
I
D
E
A
-----
N
E
-----
I
----------------------------------
E
S
P
I
E
K
G
M
V
L
S
T
L
A
Y
H
L
A
I
---
A
-------------
G
Y
-------
P
D
N
A
L
E
I
F
N
I
A
------
F
D
T
I
I
G
A
-------
E
T
-----
S
Y
T
H
K
V
D
G
I
L
R
I
G
D
L
L
E
K
A
G
D
--------------
T
L
P
S
N
E
A
M
D
F
Y
K
-
M
A
F
D
I
F
D
K
-------------------------------------------------
L
H
V
N
----------
Q
R
A
A
I
V
E
K
-
K
I
E
-
L
------
A
K
T
V
Y
D
V
G
L
P
Q
---
I
R
A
A
L
L
K
G
K
N
H
Y
A
L
A
I
I
K
K
K
Y
S
G
V
M
R
L
I
G
E
L
E
V
A
L
W
M
K
R
V
N
N
M
E
Y
L
D
V
V
D
K
A
F
E
-
C
C
E
S
P
R
F
------
T
D
V
-
N
V
------
Q
H
I
A
-
R
L
L
T
E
L
G
N
L
--
R
R
A
L
-
K
F
A
K
----
E
I
Q
N
I
H
K
R
S
-
E
-
A
L
K
-
A
I
A
L
E
L
V
R
R
K
---------
K
----
F
E
E
-----
V
K
K
-
I
I
E
S
I
P
D
P
K
I
R
E
E
A
L
N
E
I
G
T
I
E
-
20
Fugue
40.86
16%
-112
- C3 -
5AFR
-
?
A:
[8-410]
L
A
N
E
L
I
E
F
V
A
-
A
T
V
T
G
I
K
N
S
P
K
E
N
E
Q
A
F
I
D
Y
L
H
C
-
Q
Y
L
E
R
F
Q
F
F
L
G
L
F
----
V
F
L
F
I
V
T
I
D
I
A
I
Y
D
A
N
L
A
N
---------------------------------------------------
S
T
L
-----
L
I
-----
I
K
Q
I
S
-
A
---
I
------------------------
Y
N
A
G
N
L
A
S
I
I
T
H
G
V
S
S
V
F
G
---
Q
L
I
K
S
D
---
I
D
K
T
R
R
K
-------
L
D
D
I
S
K
Q
F
Q
Q
L
------
H
T
S
I
E
T
P
-------
D
L
L
A
M
V
P
S
-----------
I
I
K
L
A
V
S
K
G
A
------
T
S
H
D
Y
A
N
Y
L
P
S
N
D
L
---
E
S
M
R
F
L
N
I
L
Q
S
I
A
N
K
W
F
L
V
L
K
-------------------------------------
Q
T
L
F
L
D
----------
E
V
E
F
W
S
N
F
-
Y
E
V
-
L
------
K
S
L
I
E
Q
T
Q
S
Q
E
---
F
Q
V
C
L
S
V
L
T
N
A
K
R
F
H
N
L
T
N
L
L
N
E
G
S
L
S
D
K
F
K
L
A
D
K
Y
N
Q
F
L
S
S
I
P
I
D
E
D
L
Q
E
L
F
P
-
V
L
A
S
S
L
K
K
F
R
Y
S
G
Y
P
V
-
Q
R
------
F
V
V
L
M
D
------------------------------
K
I
-
S
-
Q
E
V
M
D
A
I
L
S
N
L
S
Y
G
---------
S
F
L
G
L
Y
E
K
-----
S
A
G
M
I
E
E
-
W
D
D
I
V
Q
D
V
N
L
L
I
R
------
3
PsiBlast_PDB
29.47
28%
-1
- C2 -
4PN3
-
?
A:
[104-211]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
E
G
A
H
K
L
E
T
F
T
-------------------------------------
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
-
E
P
G
Q
G
------
G
E
R
G
V
I
I
N
T
A
S
VAA
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
--
P
M
M
A
G
M
P
----------------------------------------------------------------------------------------------------------------------------------
18
Fugue
27.87
30%
257
* C2 *
4MQV
-
SMAL1_HUMAN
B:
[1-26]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
-----
E
E
Q
-
R
K
K
-
I
E
E
N
R
Q
K
A
L
A
R
R
A
E
K
L
L
A
-
25
Fugue
27.48
31%
340
* C3 *
3KJ1
2
B:
[1-22]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
-
I
W
A
-
A
Q
E
L
R
R
I
G
D
E
F
N
A
Y
Y
R
---
19
Fugue
27.35
22%
261
- C2 -
3V86
-
?
A:
[1-27]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
-----
Y
Q
L
-
K
D
E
-
V
G
E
L
K
G
E
V
R
A
L
K
D
E
V
K
D
L
K
17
Fugue
27.20
31%
295
- C2 -
1LBJ
-
A:
[1-22]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
P
-
I
F
T
-
Y
G
E
L
Q
R
M
Q
E
K
E
R
N
K
G
Q
---
10
HHSearch
23.49
16%
301
- C2 -
1LBJ
-
A:
[1-19]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
P
-----
I
F
T
-
Y
G
E
-
L
Q
R
M
Q
E
K
E
R
N
---------
13
HHSearch
18.07
23%
84
- C2 -
1HGV
-
CAPSD_BPH75
A:
[13-43]
------------------------------------------------------------------------------
T
N
Y
I
Q
A
I
A
A
A
G
V
G
V
L
A
L
A
I
G
L
S
A
A
W
K
Y
A
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
17.31
37%
108
- C2 -
3KZG
-
?
A:
[143-181]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
R
N
N
Q
V
I
-
F
Y
E
L
I
Q
D
------
M
L
L
G
L
S
N
N
Q
V
D
A
S
L
M
D
Y
E
A
-
A
K
Y
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
12.72
51%
232
- C2 -
4WMZ
-
?
A:
[7-29]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
-
G
E
A
L
E
Y
V
N
I
G
---------
L
S
H
F
L
A
L
P
-----
L
A
Q
------------------------
14
HHSearch
12.42
4%
132
- C2 -
1LDF
-
GLPF_ECOLI
A:
[234-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
-
P
L
F
G
P
I
V
G
A
I
---------
V
G
A
F
A
Y
R
K
-----
L
I
G
-
R
H
L
--------------------