@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2716: (2016-04-06 )
MGKDLRNYKGIKKIMAILAVFTLVQGAAIIVMAITLARAITDLFHEHPFQSVTIQIGLFAGAYFLRHFLNVWKKQIVYRYAAKLAKTMREELLDSLFALGPRFARAEGTGKVVTMVMEGVADFRNYLELFLPKMMNMAIIPAMIWVYIAFQDWTSAFILMITLPILIVFMIILGLAAKKQADSQFETYRVLSNHFVDSLKGLETLKYLGLSHDHEGKIASVSSRYRKATMKTLRVAFMSSFALDFFTMLSIALVALFLGLGLIDGNMNLPIALSVLILAPEYFLPVREVGSDYHATLDGQEAGRVIQGIIDQAKAEKPEMDALPLTTFAENTEFSFENITVKHGADDADSLHKASFTVKGFEKIGIIGATGAGKSTLIDVLSGFLTPTSGEFHWNGKSGASLASTDWQTQVTYIPQHPYLFHDTIAGNIRFYHPNSTEDEMKKAAESAGLNKLVAGLEDGYETLVGEAGRMLSGGQEQRVALARAFLTDRPVVLMDEPTAHLDIETEYELKKPMLDLFEDRLVFFATHRLHWMLEMDRIIVLDHGAVVETGTHEELLSRKGFYYNLVKAQLEEV
Atome Classification :
(31 SA)
-------------------------------------------------------.........10..-......20.---...-....--30..------......40.......--------------------.---50........60.........70........80.-.......90........100.......110.....---..120.......130.......140.......---150.......160.......170......--.180...-....190--.....-..200.......----210.......220.......230........240.......250..---.....260.-----------.---.-......270.......280.......290.----..-....300.......310.-......320--.....-..330----..--.....340....-...350.......360.......370.......380..--....---.390.-....--.-.400.......410.......420........430.--....---.-..440.......450.-.-.....460.......470.......480.......490.......500.......510......--.--520-.--.-.....530....-...540.......550....--...--560........570..-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------MGK
D
L
R
N
Y
K
G
I
K
K
-
I
M
A
I
L
A
V
F
T
---
L
VQ-
G
A
A
I
--
I
V
M
A
------
I
T
L
A
R
A
I
T
D
L
F
H
EHP--------------------F---
Q
S
V
T
I
Q
I
G
L
F
A
-
G
A
Y
F
L
R
H
F
L
N
V
W
K
K
Q
I
V
Y
R
Y
A
A
-
K
L
A
K
T
M
R
E
E
L
L
D
S
L
F
ALGPRFARAEGT
G
K
V
V
T
M
V
M
---
E
G
V
A
D
F
R
N
Y
L
E
L
F
L
P
K
M
M
N
M
A
I
I
P
A
M
I
W
V
Y
I
A
---
F
Q
DW
T
S
A
F
I
L
M
I
T
L
P
I
L
I
V
F
M
I
I
L
GLAAK--KQADS
Q
F
-
E
T
Y
R
V
L
S
--
N
H
F
V
D
-
S
L
K
G
L
E
T
L
K
Y
LG----LSHDHEG
K
I
A
S
V
S
S
R
Y
R
K
A
T
M
K
-
T
L
R
V
A
F
M
S
S
F
A
L
D
F
F
T
M
L
S
I
A
L
V
---
A
L
F
L
G
L
--
G
-----------L---I-DGNMNLP
I
A
L
S
V
L
I
LAPE
Y
F
L
P
V
R
E
VGSDY----HA-TLD
G
Q
E
A
G
R
V
I
Q
G
I
I
D
Q
A
-KAEKPEMDA--LPLTT-FAENT----EF--SF
E
N
I
T
V
KHGAD-
D
A
D
S
L
HKA
S
F
T
V
KG
F
E
K
I
G
I
I
GATGAG
K
S
T
L
I
D
V
L
S
G
F--LTPT---S
G
E
F
H
-WNGK--S-GASLASTDW
Q
T
Q
V
T
YIPQH
P
Y
L
F
-
H
DTIAG
N
I
R
F
-Y--HPNS---
T
-
E
D
E
M
K
K
A
A
E
SA
G
L
N
K
L
-
V
-
A
G
L
E
D
G
Y
E
T
L
V
GEAGRMLSGG
Q
E
Q
R
V
A
L
A
R
A
F
LTDR
P
V
V
L
MDEPTA
H
L
D
I
E
T
E
Y
E
LK
K
P
M
L
D
L
F
--E--D
R
L
-
V
--
F
-
F
A
T
H
R
L
H
W
M
L
EM-
D
R
I
I
V
L
DHG
A
V
VETG
T
H
E
E
L
--
L
S
R--K-G
F
Y
Y
N
L
V
K
A
Q
L
EEV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
87.03
23%
-121
- C2 -
4Q4A
1
Y288_THEMA
B:
[38-590]
-----------------------------------------------------------------------
T
L
I
M
V
F
V
---
F
V
T
-
V
S
S
I
L
G
V
L
S
P
------
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--------------------
F
---
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
-
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
---
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
---
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--
Q
T
R
K
Y
F
Y
-
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
----
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
-
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
---
S
G
F
G
G
W
--
L
-----------
A
---
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
----
N
M
-
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
-
E
E
E
K
D
D
P
D
A
--
V
E
L
R
E
-
V
--
R
G
----
E
I
--
E
F
K
N
V
W
F
S
Y
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
--
Y
D
V
D
---
R
G
Q
I
L
-
V
D
G
I
--
D
-
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
G
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
-
I
-
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
-
S
--
I
-
I
I
A
H
R
L
N
T
I
K
N
A
-
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
85.59
23%
-120
- C2 -
3QF4
1
Y288_THEMA
B:
[38-590]
-----------------------------------------------------------------------
T
L
I
M
V
F
V
---
F
V
T
-
V
S
S
I
L
G
V
L
S
P
------
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--------------------
F
---
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
-
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
---
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
---
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--
Q
T
R
K
Y
F
Y
-
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
----
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
-
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
---
S
G
F
G
G
W
--
L
-----------
A
---
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
----
N
M
-
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
-
E
E
E
K
D
D
P
D
A
--
V
E
L
R
E
-
V
--
R
G
----
E
I
--
E
F
K
N
V
W
F
S
Y
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
--
Y
D
V
D
---
R
G
Q
I
L
-
V
D
G
I
--
D
-
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
G
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
-
I
-
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
-
S
--
I
-
I
I
A
H
R
L
N
T
I
K
N
A
-
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
84.99
23%
-114
- C2 -
4Q4H
-
Y288_THEMA
B:
[38-590]
-----------------------------------------------------------------------
T
L
I
M
V
F
V
---
F
V
T
-
V
S
S
I
L
G
V
L
S
P
------
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--------------------
F
---
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
-
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
---
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
---
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--
Q
T
R
K
Y
F
Y
-
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
----
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
-
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
---
S
G
F
G
G
W
--
L
-----------
A
---
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
----
N
M
-
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
-
E
E
E
K
D
D
P
D
A
--
V
E
L
R
E
-
V
--
R
G
----
E
I
--
E
F
K
N
V
W
F
S
Y
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
--
Y
D
V
D
---
R
G
Q
I
L
-
V
D
G
I
--
D
-
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
G
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
-
I
-
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
-
S
--
I
-
I
I
A
H
R
L
N
T
I
K
N
A
-
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
84.67
23%
-116
- C2 -
4Q4J
-
Y288_THEMA
B:
[38-590]
-----------------------------------------------------------------------
T
L
I
M
V
F
V
---
F
V
T
-
V
S
S
I
L
G
V
L
S
P
------
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--------------------
F
---
D
L
L
P
R
Y
M
L
I
L
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
-
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
---
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
---
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--
Q
T
R
K
Y
F
Y
-
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
----
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
-
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
---
S
G
F
G
G
W
--
L
-----------
A
---
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
----
N
M
-
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
-
E
E
E
K
D
D
P
D
A
--
V
E
L
R
E
-
V
--
R
G
----
E
I
--
E
F
K
N
V
W
F
S
Y
D
K
K
-
K
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
--
Y
D
V
D
---
R
G
Q
I
L
-
V
D
G
I
--
D
-
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
G
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
-
I
-
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
-
S
--
I
-
I
I
A
H
R
L
N
T
I
K
N
A
-
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
81.60
21%
-102
- C2 -
3WMG
6
?
A:
[16-598]
---------------------------------------------------------
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
---
I
L
E
-
G
A
T
L
--
P
A
F
A
------
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
------------------
E
---
G
E
T
W
K
Y
S
V
G
F
V
-
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
-
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
---
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
-
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
---
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
--
G
N
T
K
R
S
S
-
E
A
Y
A
S
A
G
--
S
V
A
A
E
-
V
F
S
N
I
R
T
T
K
A
F
E
----
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
-
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
---
L
W
W
G
G
Q
--
L
-----------
I
---
A
-
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
----
P
D
-
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
-
P
Q
Y
R
R
P
D
P
G
A
E
V
V
T
Q
P
-
L
V
L
K
Q
----
G
I
--
V
F
E
N
V
H
F
R
Y
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
--
Y
D
I
E
PQG
G
G
L
L
L
-
F
D
G
T
--
P
-
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
L
Y
-
G
--
K
R
D
A
---
T
-
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
-
V
-
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
-
S
--
V
-
V
I
A
H
R
L
S
T
V
A
R
A
-
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
--
M
A
L
GP
S
-
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.64
24%
-92
- C2 -
2HYD
3
Y1866_STAAM
A:
[79-576]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
R
Q
Y
L
A
Q
W
T
-------
S
N
-
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
---
N
D
V
E
Q
T
K
D
F
I
---
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
--
K
L
T
R
E
R
S
-
Q
A
L
A
E
V
Q
--
G
F
L
H
E
-
R
V
Q
G
I
S
V
V
K
S
F
A
----
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
-
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
------
I
G
V
--
G
-----------
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
----
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
-
L
I
D
E
D
-
Y
D
I
K
N
G
V
G
A
--
Q
P
I
E
I
---
K
Q
G
----
R
I
--
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
--
Y
D
V
T
---
S
G
Q
I
L
-
I
D
G
H
--
N
-
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
-
G
--
R
P
T
A
---
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
-
I
-
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
-
T
--
L
-
I
V
A
H
R
L
S
T
I
T
H
A
-
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
78.21
21%
-96
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[7-572]
-------------------------------------------------------
A
R
K
L
L
G
L
A
Y
P
E
R
R
-
R
L
A
A
A
V
G
F
L
---
T
M
S
-
S
V
I
S
--
M
S
A
P
------
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--------------------
V
DY
S
D
N
L
T
R
L
C
L
G
L
S
-
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
-
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
---
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
---
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
--
K
L
T
K
V
T
Q
-
D
S
L
A
Q
A
T
--
Q
L
A
E
E
-
R
I
G
N
V
R
T
V
R
A
F
G
----
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
-
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
---
L
Y
K
G
G
L
--
L
-----------
M
---
G
-
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
----
S
E
-
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
-
P
K
L
P
F
N
-
E
G
--
V
I
L
N
E
-
K
S
F
Q
G
----
A
L
--
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
--
Y
D
P
A
---
S
G
T
I
S
-
L
D
G
H
--
D
-
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
-
G
--
A
D
D
P
SSV
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
-
I
-
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
-
V
--
L
-
V
I
A
H
R
L
S
T
I
K
N
A
-
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
--
L
S
K
P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.91
24%
-92
- C2 -
2ONJ
4
Y1866_STAAM
A:
[79-576]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
R
Q
Y
L
A
Q
W
T
-------
S
N
-
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
---
N
D
V
E
Q
T
K
D
F
I
---
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
--
K
L
T
R
E
R
S
-
Q
A
L
A
E
V
Q
--
G
F
L
H
E
-
R
V
Q
G
I
S
V
V
K
S
F
A
----
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
-
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
------
I
G
V
--
G
-----------
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
----
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
-
L
I
D
E
D
-
Y
D
I
K
N
G
V
G
A
--
Q
P
I
E
I
---
K
Q
G
----
R
I
--
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
--
Y
D
V
T
---
S
G
Q
I
L
-
I
D
G
H
--
N
-
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
-
G
--
R
P
T
A
---
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
-
I
-
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
-
T
--
L
-
I
V
A
H
R
L
S
T
I
T
H
A
-
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
77.05
21%
-93
- C2 -
3B60
2
MSBA_SALTY
A:
[15-581]
---------------------------------------------------------
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
---
I
L
N
-
A
A
S
D
--
T
F
M
L
------
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--------------------
R
---
S
V
L
L
W
M
P
L
V
V
I
-
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
-
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
---
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
---
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
--
S
I
S
K
N
M
Q
-
N
T
M
G
Q
V
T
--
T
S
A
E
Q
-
M
L
K
G
H
K
E
V
L
I
F
G
----
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
-
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
---
L
Y
A
A
S
F
--
P
-----------
S
---
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
----
A
Q
-
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
-
Q
E
K
D
E
------
G
K
R
V
I
-
D
R
A
T
G
----
D
L
--
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
--
Y
D
I
D
---
E
G
H
I
L
-
M
D
G
H
--
D
-
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
-
A
--
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
-
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
-
S
--
L
-
V
I
A
H
R
L
S
T
I
E
Q
A
-
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
--
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Fugue
76.47
20%
-93
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------------------------------------W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
---
I
L
N
-
A
A
S
D
--
T
F
M
L
------
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--------------------
R
---
S
V
L
L
W
M
P
L
V
V
I
-
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
-
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
---
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
---
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
--
S
I
S
K
N
M
Q
-
N
T
M
G
Q
V
T
--
T
S
A
E
Q
-
M
L
K
G
H
K
E
V
L
I
F
G
----
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
-
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
---
L
Y
A
A
S
F
--
P
-----------
S
---
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
----
A
Q
-
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
-
Q
E
K
D
E
G
K
R
V
--
I
D
R
A
-----
T
G
----
D
L
--
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
--
Y
D
I
D
---
E
G
H
I
L
-
M
D
G
H
--
D
-
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
-
A
--
R
T
E
E
Y--
S
-
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
-
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
-
S
--
L
-
V
I
A
H
R
L
S
T
I
E
Q
A
-
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
--
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.41
23%
-93
- C2 -
3B60
2
MSBA_SALTY
A:
[10-579]
--------------------------------------------------------------
W
Q
T
F
R
R
-
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
-
G
I
A
L
--
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
--------------------
D
---
R
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
-
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
-
G
A
S
I
I
G
L
F
I
M
M
F
-----
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
--
S
I
S
K
N
M
Q
-
N
T
M
G
Q
V
T
--
T
S
A
E
Q
-
M
L
K
G
H
K
E
V
L
I
F
G
----
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
-
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
MD
S
-----------
L
---
T
-
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
--
L
K
S
L
T
N
V
N
A
Q
F
----
Q
R
----
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
-
Q
E
K
D
E
G
K
R
V
--
I
D
R
A
T
-----
G
----
D
L
--
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
--
Y
D
I
D
---
E
G
H
I
L
-
M
D
G
H
--
D
-
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
-
A
--
R
T
E
E
Y--
S
-
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
-
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
-
S
--
L
-
V
I
A
H
R
L
S
T
I
E
Q
A
-
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
--
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.26
25%
-92
- C2 -
4S0F
2
?
A:
[216-722]
-----------------------------------------------------------------------------------------------------------------------------------------------------
F
A
-
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
-
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
---
D
A
-
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
---
I
Q
N
S
S
L
F
F
I
S
F
I
---
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
--
S
A
L
V
E
-
S
V
K
G
I
E
T
I
K
S
F
G
----
A
E
E
Q
T
E
-----------
K
S
T
R
D
-
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
---
G
I
V
A
G
L
--
G
G
I
V
I
L
W
A
G
A
Y
N
V
---
I
-
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
-
I
D
L
----
Q
P
-
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
-
A
T
E
K
E
L
R
E
D
--
S
D
D
F
V
-
I
S
L
K
G
----
D
I
--
E
F
R
N
V
D
F
R
Y
G
L
R
-
K
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
--
Y
S
P
E
---
K
G
D
I
L
-
I
N
G
H
--
S
-
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
-
S
G
T
V
K
E
N
L
C
L
-
G
--
N
E
N
V
---
D
-
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
-
I
-
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
-
V
--
I
-
I
I
A
H
R
L
S
T
I
V
N
C
-
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
--
I
A
L
--
K
-
G
C
Y
F
K
M
W
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.10
25%
-106
- C2 -
4RY2
-
?
A:
[216-722]
-----------------------------------------------------------------------------------------------------------------------------------------------------
F
A
-
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
-
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
---
D
A
-
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
---
I
Q
N
S
S
L
F
F
I
S
F
I
---
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
--
S
A
L
V
E
-
S
V
K
G
I
E
T
I
K
S
F
G
----
A
E
E
Q
T
E
-----------
K
S
T
R
D
-
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
---
G
I
V
A
G
L
--
G
G
I
V
I
L
W
A
G
A
Y
N
V
---
I
-
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
-
I
D
L
----
Q
P
-
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
-
A
T
E
K
E
L
---------------
G
----
D
I
--
E
F
R
N
V
D
F
R
Y
G
L
R
-
K
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
--
Y
S
P
E
---
K
G
D
I
L
-
I
N
G
H
--
S
-
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
-
S
G
T
V
K
E
N
L
C
L
-
G
--
N
E
N
V
---
D
-
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
-
I
-
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
-
V
--
I
-
I
I
A
H
R
L
S
T
I
V
N
C
-
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
--
I
A
L
--
K
-
G
C
Y
F
K
M
W
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Fugue
66.85
21%
-102
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
R
Y
T
T
T
L
E
K
-
L
L
L
F
I
G
T
L
V
---
A
V
I
T
G
A
G
L
--
P
L
M
S
------
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
---
E
H
D
V
M
N
V
V
W
S
Y
-
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
---
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
---
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
--
T
F
A
I
R
E
T
-
L
R
Y
A
K
A
G
--
K
V
V
E
E
-
T
I
S
S
I
R
T
V
V
S
L
N
----
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
-
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
----
A
F
Y
I
G
V
--
G
-----------
W
---
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
----
A
V
-
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
-----
K
P
V
I
D
S
--
S
S
K
A
G
-
R
K
D
M
K
IK
G
-
D
I
--
T
V
E
N
V
H
F
T
Y
P
S
R
P
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
--
Y
D
V
L
---
K
G
K
I
T
-
I
D
G
V
--
D
-
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
-
N
C
T
I
E
E
N
I
S
L
-
G
--
K
E
G
I
---
T
-
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
-
I
-
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
--
K
--
G
R
T
-
T
--
I
-
I
I
A
H
R
L
S
T
I
R
N
A
-
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
--
M
A
Q
--
Q
-
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
3
PsiBlast_PDB
65.51
24%
-92
- C2 -
4A82
-
Y1866_STAAM
A:
[79-576]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
R
Q
Y
L
A
Q
W
T
-------
S
N
-
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
---
N
D
V
E
Q
T
K
D
F
I
---
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
--
K
L
T
R
E
R
S
-
Q
A
L
A
E
V
Q
--
G
F
L
H
E
-
R
V
Q
G
I
S
V
V
K
S
F
A
----
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
-
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
------
I
G
V
--
G
-----------
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
----
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
-
L
I
D
E
D
-
Y
D
I
K
N
G
V
G
A
--
Q
P
I
E
I
---
K
Q
G
----
R
I
--
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
--
Y
D
V
T
---
S
G
Q
I
L
-
I
D
G
H
--
N
-
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
-
G
--
R
P
T
A
---
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
-
I
-
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
-
T
--
L
-
I
V
A
H
R
L
S
T
I
T
H
A
-
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.57
31%
-88
- C2 -
4MYC
-
ATM1_YEAST
A:
[202-570]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
-
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
----
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
-----
M
Y
M
G
C
T
-
G
-----------
V
---
I
-
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
-
L
I
D
M
E
T
L
F
K
L
R
K
N
E
V
K
I
K
-
N
A
E
R
P
L
M
----
L
P
------
E
N
V
----
P
Y
D
I
T
F
E
N
V
T
F
G
Y
H
P
D
--
R
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
--
Y
D
P
E
---
S
G
R
I
L
-
I
N
G
R
--
D
-
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
-
N
D
T
I
W
E
N
V
K
F
-
G
--
R
I
D
A
---
T
-
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
-
I
-
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
F
--
T
SG
S
R
T
-
S
--
V
-
Y
I
A
H
R
L
R
T
I
A
D
A
-
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
--
L
A
M
--
P
-
G
S
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
63.05
31%
-87
- C2 -
4MYH
1
ATM1_YEAST
B:
[202-570]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
-
S
L
I
N
F
E
A
V
K
Y
F
N
NEKY
L
A
D
K
Y
N
G
S
L
M
N
----
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
-----
M
Y
M
G
C
T-
G
-----------
V
---
I
-
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
RDLK
Q
S
-
L
I
D
M
E
T
L
F
K
L
R
K
N
E
V
K
I
K
-
N
A
E
R
P
L
M
----
L
P
------
E
N
V
----
P
Y
DI
T
F
E
N
V
T
F
G
Y
H
P
D
--
R
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
--
Y
D
P
E
---
S
G
R
I
L
-
I
N
G
R
--
D
-
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
-
N
D
T
I
W
E
N
V
K
F
-
G
--
R
I
D
A
---
T
-
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
-
I
-
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
F
--
T
SG
S
R
T
-
S
--
V
-
Y
I
A
H
R
L
R
T
I
A
D
A
-
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
--
L
A
M
--
P
-
G
S
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.21
31%
-87
- C2 -
4MYH
-
ATM1_YEAST
A:
[202-570]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
-
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
----
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
-----
M
Y
M
G
C
T
-
G
-----------
V
---
I
-
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
-
L
I
D
M
E
T
L
F
K
L
R
K
N
E
V
K
I
K
-
N
A
E
R
P
L
M
----
L
P
------
E
N
V
----
P
Y
D
I
T
F
E
N
V
T
F
G
Y
H
P
D
--
R
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
--
Y
D
P
E
---
S
G
R
I
L
-
I
N
G
R
--
D
-
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
-
N
D
T
I
W
E
N
V
K
F
-
G
--
R
I
D
A
---
T
-
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
-
I
-
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
F
--
T
SG
S
R
T
-
S
--
V
-
Y
I
A
H
R
L
R
T
I
A
D
A
-
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
--
L
A
M
--
P
-
G
S
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.50
31%
-89
- C2 -
3WMG
2
?
A:
[255-596]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
---
A
L
W
W
G
G
--
Q
-----------
L
---
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
----
P
D
-
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
P
G
A
--
E
V
V
T
Q
P
L
V
L
K
Q
----
G
I
--
V
F
E
N
V
H
F
R
Y
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
YD
I
E
P
Q
---
G
G
G
L
L
L
F
D
G
T
--
P
-
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
L
Y
-
G
--
K
R
D
A
---
T
-
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
-
V
-
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
--
A
--
S
D
G
-
V
T
S
V
-
V
I
A
H
R
L
S
T
V
A
R
A
-
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
G
P
--
S
-
G
F
Y
Y
Q
L
V
E
K
Q
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
55.92
35%
-93
- C2 -
2FF7
1
A:
[5-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
----
D
I
--
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
--
Y
I
P
E
---
N
G
Q
V
L
-
I
D
G
H
--
D
-
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
G
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
-
I
-
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
-
V
--
I
-
I
I
A
H
R
L
S
T
V
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
55.29
35%
-92
- C2 -
3VX4
3
?
D:
[28-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
FLDG
D
I
--
S
F
E
N
L
S
Y
K
Y
G
F
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
--
Y
E
P
N
---
K
G
I
V
R
-
I
N
G
N
--
D
-
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
A
--
K
E
G
T
---
S
-
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
-
I
-
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
--
K
T
I
-
I
--
F
-
V
A
-
H
R
L
S
I
S
Q
R
T
-
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
--
L
A
K
--
Q
-
G
F
Y
Y
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.07
35%
-94
- C2 -
3VX4
3
?
A:
[29-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
FL
D
G
D
I
--
S
F
E
N
L
S
Y
K
Y
G
F
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
--
Y
E
P
N
---
K
G
I
V
R
-
I
N
G
N
--
D
-
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
A
--
K
E
G
T
---
S
-
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
-
I
-
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
--
K
T
I
-
I
--
F
-
V
A
-
H
R
L
S
I
S
Q
R
T
-
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
--
L
A
K
--
Q
-
G
F
Y
Y
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
52.09
32%
-91
- C2 -
3VX4
3
?
A:
[29-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
G
----
D
I
--
S
F
E
N
L
S
Y
K
Y
G
F
--
G
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
--
Y
E
P
N
---
K
G
I
V
R
-
I
N
G
N
--
D
-
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
-
G
--
A
K
E
G
---
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
-
I
-
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
---
T
--
E
K
T
-
I
--
I
-
F
V
A
H
R
L
S
I
S
Q
R
T
-
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
--
L
A
K
--
Q
-
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
46.31
35%
-86
- C2 -
4AYX
2
ABCBA_HUMAN
A:
[364-574]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
--
Y
D
P
A
---
S
G
T
I
S
-
L
D
G
H
--
D
-
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
-
G
AD
D
P
S
S
V--
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
-
I
-
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
-
V
--
L
-
V
I
A
H
R
L
S
T
I
K
N
A
-
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
--
L
S
K
P-
N
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
40.92
35%
-80
- C2 -
4AYT
2
ABCBA_HUMAN
A:
[364-567]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
--
Y
D
P
A
---
S
G
T
I
S
-
L
D
G
H
--
D
-
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
-
G
AD
D
P
S
S
V--
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
-
I
-
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
-
V
--
L
-
V
I
A
H
R
L
S
T
I
K
N
A
-
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
40.50
34%
-87
- C2 -
4AYW
1
ABCBA_HUMAN
A:
[395-598]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
--
Y
D
P
A
---
S
G
T
I
S
-
L
D
G
H
--
D
-
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
-
G
AD
D
P
S
S
V--
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
-
I
-
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
-
V
--
L
-
V
I
A
H
H
L
S
T
I
K
N
A
-
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
36.56
33%
-66
- C2 -
4YMV
1
?
A:
[15-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
--
E
E
P
T
---
K
G
E
V
F
-
I
D
G
V
KI
N
-
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
---
P
V
K
---
V
-
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
-
A
K
V
G
L
L
D
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
M
T
M
--
V
-
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
--
F
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
36.38
33%
-71
- C2 -
4YMU
2
?
A:
[15-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
--
E
E
P
T
---
K
G
E
V
F
-
I
D
G
V
KI
N
-
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
---
P
V
K
---
V
-
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
-
A
K
V
G
L
L
D
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
M
T
M
--
V
-
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
--
F
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
35.79
33%
-66
- C2 -
4YMV
1
?
J:
[15-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
--
E
E
P
T
---
K
G
E
V
F
-
I
D
G
V
KI
N
-
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
---
P
V
K
---
V
-
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
-
A
K
V
G
L
L
D
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
M
T
M
--
V
-
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
--
F
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
35.68
33%
-67
- C2 -
4YMU
2
?
J:
[15-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
--
E
E
P
T
---
K
G
E
V
F
-
I
D
G
V
KI
N
-
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
---
P
V
K
---
V
-
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
-
A
K
V
G
L
L
D
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
M
T
M
--
V
-
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
--
F
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
28.82
33%
-58
- C2 -
4U00
3
?
A:
[31-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
--
E
D
F
Q
---
E
G
E
V
V
-
V
D
G
L
--
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
-
A
---
P
M
R
---
V
-
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
-
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
--
Q
--
G
G
M
-
T
--
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
--
F
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------