@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2720: (2016-04-06 )
MNSENLIAPELYNITDEIAKFSSEKTALIWKNEHGETKTWSYHHLLEQANKFANVAKDAGIKKGDHVIVMTPRLLETYAIYMGLWKAGAIIIPASELLKAHDLEYRIHHANVKAIVSYNGMTAEFDKIESIPSVSKKIIVGDKLSGWEQYETLMEAAPTEFERVETSRDDACLLAFTSGTTGNPKGVVHIHGWGYAHIRIAADHWLDIHEDDIVWATAGPGWQKWVWSPFLSVLGKGATGFIYNGRFIPEKQLHLLEEEKINVLCCTPTEYRLMAKVNNLREHDLSSLRSAVSAGEPLNREVIQVFRDNFDIKVRDGYGQTESTLLIGTLVDTPIRPGSMGKPIMPEYMAIIDADGNPVGVGEIGDIAMRRDFPALFKEYYKEPERLQKAIRGDYFVSGDRAIRDEDNYYWFQGRNDDIIISSGYTIGPFEVEDALTHHPAVKEVAVVASPDEIRGTVVKAFIVVKDGYKGTDDLVHELQTFTKEQTAPYKYPRRIEFVEALPKTDSGKIRRVELRDAEFASVHG
Atome Classification :
(20 SA)
.........10........20........30-........40........50......-..-60........70........80........90........100.......110.......-120.--------......130..---------..--.--...140.-...---...-----150......----.160.----......170.......180.......190.......200..---.....210.......220.......230.......240.-.-...---..250.......260.......270-.......280-.......290.......300.......310-.........320.......330...------....340.......350.......360.....---..370--..---.......380.......390...---....400.......410.......420.......430.......440.......450.......460.......470...--......480.......490.......500.......510.......520...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNSENLI
A
P
E
L
Y
N
I
T
D
E
I
A
K
FSSE
K
T
A
L
I
W
K-NEHGETK
T
W
S
Y
H
H
L
L
E
Q
A
N
K
F
A
N
V
A
K
-DA-GIKKG
D
H
V
I
V
M
T
P
R
L
L
E
T
Y
A
I
Y
M
G
L
WKA
G
A
I
I
I
P
A
S
E
L
L
K
AHD
L
E
Y
R
I
H
HA
N
V
K
A
I
V
SYN-GMTA--------
E
F
D
K
I
E
S-IPS---------VS--
K
--
K
I
I
VGDK-LS
G
---
W
E
Q
-----
Y
E
T
L
M
E
AAP----T
E
F
E
R
----VETSRD
D
A
C
L
L
A
F
TSGTTGNP
K
G
V
V
H
IHGW
G
Y
A
H
I
R
I
A
A
D
H
---
W
L
DIHED
D
I
V
W
A
TAGPGWQK
W
V
W
S
P
F
L
S
V
LGKGA
T
G
F
I
Y-N-
G
R
F---I
P
E
K
Q
L
H
L
L
E
EEK
I
N
V
L
C
CTPT
E
Y
R
-
L
M
A
K
V
N
N
L
R
E
-
H
D
L
S
S
L
R
S
A
V
SAGEPL
N
R
E
V
I
Q
V
F
RDNF---
D
I
K
V
RDGYGQT
E
S
T
L
L
I
G
T
LVDTPI------RPGSMGKPI
M
P
E
Y
M
A
I
I
DADGNPVGV
G
E
I
G
D
I
---
A
M
R----R
D
---
F
P
A
L
F
K
E
Y
YK
E
P
E
R
L
Q
K
A
IRG
D
Y
---FVSGDRAIRDED
N
Y
Y
W
F
QGRND
D
I
I
ISSG
Y
T
IG
P
F
E
V
E
D
ALTHHPAV
K
E
V
A
V
VA
S
P
D
E
I
R
G
T
V
V
K
A
F
I
V
V
KDGYK--
G
T
D
--
D
L
V
H
E
L
Q
T
F
T
K
EQTAPYKYP
R
R
I
E
F
V
E
ALPKTDSG
K
I
R
R
V
E
LRDAEFASVHG
43
HHSearch
94.38
37%
-94
- C3 -
3C5E
7
ACS2A_HUMAN
A:
[54-562]
-------------------
G
K
R
P
P
S
P
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
-
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
-
D
A
G
---
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
L
-
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
Q
D
-
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
----
V
K
P
I
R
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
SH
D
P
E
--
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
----
21
PsiBlast_CBE
94.26
40%
-87
- C3 -
3ETC
10
?
B:
[59-562]
-----------
Y
D
V
V
D
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
-
D
D
Y
G
N
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
-
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
-----
I
A
--------
E
D
D
V
P
E
Q
-
V
D
E
A
H
A
E
C
GDIP
L
K
--
K
--
A
K
V
G
G
D
V
-
L
E
G
---
W
I
D
-----
F
R
K
E
L
E
E
S
S
----
P
I
F
E
R
PTGE
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
-
L
T
A
K
Y
---
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
-
D
Y
D
R
F
---
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
-
F
L
I
K
-
E
D
L
S
H
-
Y
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
I
K
L
M
E
G
F
G
Q
T
E
T
V
V
T
I
A
T
F
P
W
M
E
P
------
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
VIN
T
M
E
----
G
K
---
P
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
L
P
K
---------------------
41
HHSearch
93.94
40%
-89
- C3 -
3ETC
11
?
A:
[60-559]
------------
D
V
V
D
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
-
D
D
Y
G
N
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
-
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
-
E
D
D
V
P
E
------
Q
V
D
E
A
H
A
E
C
G
D
---------
I
P
--
L
K
K
A
K
V
G
G
D
V
-
L
E
G
---
W
I
D
-----
F
R
K
E
L
E
E
S
S
PIFE
R
P
T
G
E
----
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
L
T
-
A
K
Y
---
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
-
D
Y
D
R
F
---
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
-
F
L
I
K
E
D
-
L
----
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
I
K
L
M
E
G
F
G
Q
T
E
T
V
V
T
I
A
T
F
P
W
M
E
P
------
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
---
V
I
N
----
T
M
EGK
P
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
------------------------
27
PsiBlast_CBE
93.49
37%
-90
- C3 -
2WD9
2
ACS2A_HUMAN
B:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
23
PsiBlast_CBE
93.33
37%
-90
- C3 -
3EQ6
2
ACS2A_HUMAN
B:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
DAG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
26
PsiBlast_CBE
93.31
37%
-90
- C3 -
2WD9
2
ACS2A_HUMAN
C:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
DAG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
1
PsiBlast_PDB
93.23
40%
-86
- C3 -
3ETC
11
?
A:
[59-559]
-----------
Y
D
V
V
D
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
-
D
D
Y
G
N
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
-
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
-----
I
A
--------
E
D
D
V
P
E
Q
-
V
D
E
A
H
A
E
C
GDIP
L
K
--
K
--
A
K
V
G
G
D
V
-
L
E
G
---
W
I
D
-----
F
R
K
E
L
E
E
S
S
----
P
I
F
E
R
PTGE
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
-
L
T
A
K
Y
---
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
-
D
Y
D
R
F
---
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
-
F
L
I
K
-
E
D
L
----
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
I
K
L
M
E
G
F
G
Q
T
E
T
V
V
T
I
A
T
F
P
W
M
E
P
------
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
VIN
T
M
E
----
G
K
---
P
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
------------------------
4
PsiBlast_PDB
93.16
37%
-96
- C3 -
3DAY
18
ACS2A_HUMAN
A:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKP
I
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
--
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
3
PsiBlast_PDB
93.07
37%
-95
- C3 -
3C5E
7
ACS2A_HUMAN
A:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKP
I
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
5
PsiBlast_PDB
93.03
37%
-89
- C3 -
2VZE
1
ACS2A_HUMAN
A:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
6
PsiBlast_PDB
92.93
37%
-90
- C3 -
3EQ6
2
ACS2A_HUMAN
A:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
8
PsiBlast_PDB
92.86
37%
-90
- C3 -
2WD9
1
ACS2A_HUMAN
A:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
25
PsiBlast_CBE
92.66
37%
-89
- C3 -
2VZE
1
ACS2A_HUMAN
B:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
7
PsiBlast_PDB
92.22
37%
-96
- C3 -
3GPC
2
ACS2A_HUMAN
A:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
--
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
24
PsiBlast_CBE
92.20
37%
-89
- C3 -
2VZE
2
ACS2A_HUMAN
C:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
DAG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
2
PsiBlast_PDB
92.01
37%
-88
- C3 -
3B7W
6
ACS2A_HUMAN
A:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
22
PsiBlast_CBE
91.40
37%
-95
- C3 -
3GPC
2
ACS2A_HUMAN
B:
[61-561]
--------------------------
A
L
W
W
V
-
N
G
K
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
-
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
-
E
V
I
Q
--------
E
V
D
T
V
A
S
E
C
P
S
---------
L
R
--
I
--
K
L
L
V
S
E
K
S
C
D
G
---
W
L
N
-----
F
K
K
L
L
N
E
A
S
----
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
---
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
F
---
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
D
L
S
S
-
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
I
------
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
---
G
I
R
VKPI
R
P
---
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
-----
11
PsiBlast_PDB
86.21
28%
-80
- C3 -
2P2M
1
ACSA_SALTY
A:
[80-621]
------------
N
C
L
D
R
H
L
Q
E
N
G
D
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
-
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
R
A
GASIP
L
K
K
N
V
D
D
A
L
K
-
N
P
N
---------
V
T
SV
E
--
H
V
I
V
L
K
R
-
T
G
S
D
I
D
W
Q
E
GRDLW
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
P
----
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
---
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
P
NWP
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
C
P
V
V
D
T
W
W
Q
T
E
T
----
G
G
F
M
I
T
P
L
PGA
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
---
V
I
T
----
D
S
---
W
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
---------
17
PsiBlast_PDB
86.13
28%
-78
- C3 -
2P2J
2
ACSA_SALTY
A:
[80-626]
------------
N
C
L
D
R
H
L
Q
E
N
G
D
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
-
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
R
A
GRSIP
L
K
K
N
V
D
D
A
L
K
-
N
P
N
---------
V
T
SV
E
--
H
V
I
V
L
K
R
-
T
G
S
D
I
D
W
Q
E
GRDLW
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
P
----
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
---
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
P
NWP
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
C
P
V
V
D
T
W
W
Q
T
E
T
----
G
G
F
M
I
T
P
L
PG
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
---
V
I
T
----
D
S
---
W
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
A
I
M
R
R
I
L
R
---------
10
PsiBlast_PDB
85.94
28%
-80
- C3 -
2P2B
2
ACSA_SALTY
A:
[80-626]
------------
N
C
L
D
R
H
L
Q
E
N
G
D
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
-
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
R
A
G
R
S
I
P
L
K
K
N
V
D
D
A
L
K
-
N
P
N
---------
V
T
SV
E
--
H
V
I
V
L
K
R
-
T
G
S
D
I
D
W
Q
E
GRDLW
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
P
----
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
---
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
P
NWP
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
A
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
C
P
V
V
D
T
W
W
Q
T
E
T
----
G
G
F
M
I
T
P
L
PGA
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
---
V
I
T
----
D
S
---
W
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
---------