@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2739: (2016-04-06 )
MNKLNEALKKAERIVFLTGAGVSVPSGIPDYRSKNGLYAGMSSPEYMLSHTCLVREPEKFYQFVTENMYYPNAVPNVIHKKMAEIETEKDVTIITQNIDGLHEKAGSKKVVNFHGSLYHCYCQNCGMTVTAKDYLKSDIHTDCGGVIRPDVVLYEEAISESAIDQSLTAIRKADLIVIVGTSFRVSPFCNLTDYRNKKARIFAVNKERISLPYPFEMMESDAVKVFEEI
Atome Classification :
(44 SA)
----------------------------------------------------------------------------------.........10........20........30.......-----.40..-------.----.....50........60.......-.-70-........80.......-----.90-.-.......100.......110.......120...--..----------------------.--.130--..---...----.----.-..140.--.-..------------.-....150.......160.......170.......180.......190-...-...--.200.......210-........220.-......-----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------M
N
K
L
N
E
A
L
K
KA
E
R
I
V
F
L
TGAGVSVPSGIPDYRSKNGLY-----AGMSS-------
P
----
E
Y
M
L
S
H
T
CLVR
E
P
E
K
F
Y
Q
F
V
T
ENM-Y-YP-NA
V
P
N
V
I
H
K
K
M
A
E
IETE-----K
D
V
-
T
-
I
I
TQNI
D
G
L
H
E
KAGS
K
K
V
V
N
FHG
S
L
Y
H
C
YCQNC--G
M
----------------------
T
--
V
T
----
A
K
---
D
Y
L
----
K
----
S
-DIH--T--D-CG------------G-VIRP
D
V
V
L
Y
E
E
AI
S
E
S
A
I
D
Q
S
L
T
A
IRKA
D
L
I
V
I
VGTSFRVSPFCNLT-DYR-NK
K
--
A
R
I
F
A
V
N
K
ERIS-L-PY
P
F
E
M
M
E
S
D
A
V
-
K
V
F
E
EI-----------------------------------------
18
PsiBlast_PDB
91.07
32%
-102
- C9 -
1M2G
2
NPD1_ARCFU
A:
[4-236]
------------------------------------------------------------------------------------
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
------
N
R
Y
R
-------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
-
E
-
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
N
S
F
----------------------
E
--
V
E
----
S
A
---
P
K
I
----
P
----
P
-
L
P
K
--
C
--
D
K
C
G
------------
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
--
G
A
I
I
E
I
N
P
D
E
T
P
-
L
T
P
I
A
D
Y
S
L
R
G
K
A
G
-
E
V
M
D
E
L
-----------------------------------------
15
PsiBlast_PDB
90.31
35%
-106
- C9 -
2H59
3
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
N
G
I
Y
-----
K
K
Y
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
27
PsiBlast_CBE
90.00
32%
-103
- C9 -
1M2J
2
NPD1_ARCFU
A:
[4-236]
------------------------------------------------------------------------------------
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
------
N
R
Y
R
-------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
-
E
-
K
V
F
N
A
Q
P
N
K
A
N
Q
A
F
A
E
L
E
R
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
--
N
N
----------------------
S
F
E
V
E
----
S
A
---
P
K
I
----
P
----
P
-
L
P
K
--
C
--
D
K
C
G
------------
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
--
G
A
I
I
E
I
N
P
D
E
T
P
-
L
T
P
I
A
D
Y
S
L
R
G
K
A
G
-
E
V
M
D
E
L
-----------------------------------------
26
PsiBlast_CBE
89.72
32%
-101
- C9 -
1M2K
2
NPD1_ARCFU
A:
[4-236]
------------------------------------------------------------------------------------
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
------
N
R
Y
R
-------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
-
E
-
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
--
N
N
----------------------
S
F
E
V
E
----
S
A
---
P
K
I
----
P
----
P
-
L
P
K
--
C
--
D
K
C
G
------------
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
--
G
A
I
I
E
I
N
P
D
E
T
P
-
L
T
P
I
A
D
Y
S
L
R
G
K
A
G
-
E
V
M
D
E
L
-----------------------------------------
34
PsiBlast_CBE
89.66
34%
-98
- C9 -
1S7G
1
NPD2_ARCFU
E:
[5-219]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
-----
R
K
Y
D
--------
P
----
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
-
D
----
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
E
R
M
-----
G
I
V
K
A
-
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
--
H
E
----------------------
T
--
Y
D
WSEF
V
E
---
D
F
N
----
K
----
G
-
E
I
P
RC
R
--
K
-
C
G
------------
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
--
Y
I
-
A
K
K
AG
A
K
M
I
I
V
N
A
E
------------------------------------------------------------------
23
PsiBlast_CBE
89.20
32%
-99
- C9 -
1M2N
2
NPD1_ARCFU
B:
[4-236]
------------------------------------------------------------------------------------
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
------
N
R
Y
R
-------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
-
E
-
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
NN
S
F
----------------------
E
--
V
E
----
S
A
---
P
K
I
----
P
----
P
-
L
P
K
--
C
--
D
K
C
G
------------
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
--
G
A
I
I
E
I
N
P
D
E
T
P
-
L
T
P
I
A
D
Y
S
L
R
G
K
A
G
-
E
V
M
D
E
L
-----------------------------------------
1
PsiBlast_PDB
88.68
35%
-113
- C9 -
1YC5
3
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.63
35%
-112
- C9 -
2H2F
2
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
-----------------
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
25
PsiBlast_CBE
88.54
32%
-100
- C9 -
1M2H
2
NPD1_ARCFU
A:
[4-236]
------------------------------------------------------------------------------------
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
A
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
------
N
R
Y
R
-------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
-
E
-
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
N
S
F
----------------------
E
--
V
E
----
S
A
---
P
K
I
----
P
----
P
-
L
P
K
--
C
--
D
K
C
G
------------
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
--
G
A
I
I
E
I
N
P
D
E
T
P
-
L
T
P
I
A
D
Y
S
L
R
G
K
A
G
-
E
V
M
D
E
L
-----------------------------------------
6
PsiBlast_PDB
88.27
35%
-109
- C9 -
2H2G
3
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
--------------
Y
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
20
PsiBlast_PDB
88.09
32%
-98
- C9 -
4TWI
2
NPD1_ARCFU
A:
[4-236]
------------------------------------------------------------------------------------
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
------
N
R
Y
R
-------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
-
E
-
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
N
S
F
----------------------
E
--
V
E
----
S
A
---
P
K
I
----
P
----
P
-
L
P
K
--
C
--
D
K
C
G
------------
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
--
G
A
I
I
E
I
N
P
D
E
T
P
-
L
T
P
I
A
D
Y
S
L
R
G
K
A
G
-
E
V
M
D
E
L
-----------------------------------------
17
PsiBlast_PDB
88.06
32%
-100
- C9 -
1M2N
2
NPD1_ARCFU
A:
[4-236]
------------------------------------------------------------------------------------
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
------
N
R
Y
R
-------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
-
E
-
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
N
S
F
----------------------
E
--
V
E
----
S
A
---
P
K
I
----
P
----
P
-
L
P
K
--
C
--
D
K
C
G
------------
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
-
Q
R
G
--
G
A
I
I
E
I
N
P
D
E
T
P
-
L
T
P
I
A
D
Y
S
L
R
G
K
A
G
-
E
V
M
D
E
L
-----------------------------------------
90
Fugue
88.02
28%
-109
- C9 -
5BTR
6
?
A:
[4-390]
DNLLFGD
E
I
I
T
N
GSDWTP
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
M
I
GTD
P
R
T
I
L
K
D
L
LPETIPPPELD
D
M
T
L
W
Q
I
V
I
N
I
L
S
E
P
P
K
R
K
KRKDINT
I
E
D
A
V
K
L
L
Q
E
S
K
K
I
I
V
L
T
G
A
G
V
S
V
S
S
G
I
P
D
F
R
S
R
D
G
I
Y
-----
A
R
L
A
V
D
F
PDLPD
P
----
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
-
I
-
Y
-
P
G
-
Q
F
Q
P
S
L
C
H
K
F
I
A
L
S
D
K
E
G----
K
L
L
-
R
-
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
I
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
--
K
Y
----------------------
K
--
V
D
-----
C
---
E
A
V
----
R
----
G
-
D
I
F
--
N
--
Q
-
V
V
PRCPRCPADEPL
A
-
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
-
S
S
I
-
P
H
E
--
V
P
Q
I
L
I
N
R
E
P
L
P
H
L
-
H
F
D
V
E
L
L
-
G
D
C
D
-
V
I
I
N
E
L
C
H
R
L
GGEYAKLSSNP
V
K
L
S
E
ITE
Q
Y
L
F
L
P
P
N
R
Y
I
F
H
GAEVY
4
PsiBlast_PDB
88.02
35%
-108
- C9 -
2H2D
2
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------------------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
7
PsiBlast_PDB
87.98
35%
-111
- C9 -
2H2H
2
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------------------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
30
PsiBlast_CBE
87.88
34%
-102
- C9 -
1YC2
17
NPD2_ARCFU
D:
[5-219]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
-----
R
K
Y
D
--------
P
----
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
-
D
-
K
L
-
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
E
R
M
-----
G
I
V
K
A
-
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
--
H
E
----------------------
T
--
Y
D
WSEF
V
E
---
D
F
N
----
K
----
G
-
E
I
P
RC
R
--
K
-
C
G
------------
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
--
Y
I
-
A
K
K
AG
A
K
M
I
I
V
N
A
E
------------------------------------------------------------------
16
PsiBlast_PDB
87.78
35%
-112
- C9 -
3JR3
2
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------
K
Y
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.76
35%
-109
- C9 -
2H4F
3
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
-----------
Y
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.74
35%
-105
- C9 -
2H2I
2
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
N
G
I
Y
-----
K
K
Y
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.73
35%
-117
- C9 -
4BV2
5
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
--------------
Y
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
57
HHSearch
87.52
31%
-102
- C9 -
1YC5
3
NPD_THEMA
A:
[3-238]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-----------------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
P
-
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
G----
L
I
E
-
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
K
K
L
E
S
S---
D
V
P
L
C
--
D
--
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
-
L
I
T
V
R
S
G
--
G
K
L
V
I
V
N
L
G
E
T
P
-
F
-
D
D
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
------------------------------------------
9
PsiBlast_PDB
87.51
35%
-110
- C9 -
3D4B
3
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------------------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.83
35%
-105
- C9 -
4BUZ
4
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
--------------
Y
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.97
35%
-116
- C9 -
4BV2
5
NPD_THEMA
B:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E----
V
P
--
L
CD
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.41
35%
-99
- C9 -
2H4H
3
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
N
---------------------VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
Y
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
CD
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.20
35%
-113
- C9 -
2H4J
4
NPD_THEMA
A:
[3-199]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
---------------
S
Q
-------
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
-
F
P
M
L
-
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
--
E
K
----------------------
K
--
Y
T
----
V
E
---
D
V
I
----
K
K
L
E
S
S
-
D
V
P
--
L
C
D
D
-
C
N
------------
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
--------------------------------------------------------------------------------------
32
PsiBlast_CBE
84.70
34%
-92
- C9 -
1YC2
8
NPD2_ARCFU
B:
[5-219]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
-----
R
K
Y
D
--------
P
----
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
-
D
-
K
L
-
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
E
R
M
-----
G
I
V
K
A
-
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
--
H
E
----------------------
T
--
Y
D
WSEF
V
E
---
D
F
N
----
K
----
G
-
E
I
P
RC
R
--
K
-
C
G
------------
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
--
Y
I
-
A
K
K
AG
A
K
M
I
I
V
N
A
E
------------------------------------------------------------------
31
PsiBlast_CBE
84.46
34%
-92
- C9 -
1YC2
7
NPD2_ARCFU
C:
[5-219]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
-----
R
K
Y
D
--------
P
----
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
-
D
-
K
L
-
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
E
R
M
-----
G
I
V
K
A
-
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
--
H
E
----------------------
T
--
Y
D
WSEF
V
E
---
D
F
N
----
K
----
G
-
E
I
P
RC
R
--
K
-
C
G
------------
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
--
Y
I
-
A
K
K
AG
A
K
M
I
I
V
N
A
E
------------------------------------------------------------------
46
PsiBlast_CBE
83.24
31%
-87
- C9 -
4UTZ
5
SIR5_DANRE
B:
[13-234]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
RKWQA
Q
D
L
A
T
-------
P
----
E
A
F
S
R
D
P
S
L
V
W
E
---
F
Y
H
Y
R
R
E
V
M
-
R
----
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
G
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
--
G
E
V
K
A
N
HKSPICPALDGKGAPDPN
T
--
K
E
----
A
R
IPV
E
L
L
----
P
----
R
-
C
E
R
--
K
--
S
-
C
N
------------
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
------------------------------------------------------------------------------------------
28
PsiBlast_CBE
83.15
34%
-106
- C9 -
4TWJ
9
NPD2_ARCFU
A:
[5-219]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
------------------------------
P
----
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
-
D
-
K
L
-
F
A
E
P
N
P
A
H
Y
A
I
A
E
L
E
R
M
-----
G
I
V
K
A
-
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
--
H
E
----------------------
T
--
Y
D
WSEF
V
E
---
D
F
N
----
K
----
G
-
E
I
P
RC
R
--
K
-
C
G
------------
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
--
Y
I
-
A
K
K
A
G
A
K
M
I
I
V
N
A
E
------------------------------------------------------------------
49
PsiBlast_CBE
83.12
31%
-84
- C9 -
4UTX
6
SIR5_DANRE
A:
[13-231]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
RKWQA
Q
D
L
A
T
-------
P
----
E
A
F
S
R
D
P
S
L
V
W
E
---
F
Y
H
Y
R
R
E
V
M
-
R
----
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
G
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
--
G
E
V
K
A
N
HKSPICPALDGKGAPDPN
T
--
K
E
----
A
R
IPV
E
L
L
----
P
----
R
-
C
E
R
--
K
--
S
-
C
N
------------
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
------------------------------------------------------------------------------------------
44
PsiBlast_CBE
82.45
31%
-84
- C9 -
4UU7
5
SIR5_DANRE
B:
[13-229]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
RKWQA
Q
D
L
A
T
-------
P
----
E
A
F
S
R
D
P
S
L
V
W
E
---
F
Y
H
Y
R
R
E
V
M
-
R
----
S
K
M
P
N
P
A
H
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HKSPICPALDGKGAPDPN
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--
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----
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----
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----
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------------
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------------------------------------------------------------------------------------------