@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2745: (2016-04-06 )
MDQKKYSWRKFFQLLISAKPANWIIFCALFASVITTVAGLVVPLFTKNLIDGFSIASLDVKMIALIVLAFILQAITNGFSIFLLNYMGQKVVATIRERLWKKIVHLPVSYFDNTKTGEMVSRMVNDTVVVKELIADHLPQFVTGIISVVGAIIILFFMDWKMTLIILVAVPITALVVAPLGQKMFKISKGLQNETANFTGSISQTLSEARLVKASNAETLETEAGHQGINRLFGFGIREAKVVAVLGPLIFFVVMGVIVGIIGYGGIRVSAGTMTTGTLIAFLLYLFQIIVPVTSFATFFAQLQKAKGATERIADILNETEEDFDAGKKVDVSGKTIRASDISFSYNEGEPILKHVSFDTKPGEVIAFAGPSGGGKSTLFAILERFYQPKTGEILVGDIPLSEISINSWRTQIGYVSQESAMLSGTIRDNLCYGLDREITEDELWNVAKLAYADGFISELPDKMATEVGERGVKLSGGQRQRIAIARAFLRNPNILMLDEATASLDSQSEQIVQQALANLMEGRTTFVIAHRLSTIVNADQILFIEHGEITGRGTHSELVASHPLYASFAEQQLK
Atome Classification :
(54 SA)
.........10........20...-.....30........-40..---......50.-.---..---..------.-.-----60.-.-....---..--70.........80.....-..---.----90........100.......110...--....120.......130.......140.......150.......160.......170.......180.......190.......200.-...-------------...210.......220.......230.......240...---....250..-..-----...260.......270.......280.......290......-.300.......310.....--------.--.320--...-----..------.---.330........340--......--...--350.---........360.......370.......380.......390-.........400--.......410.......420...-....430....--..--.440.........450.......460.......470.--......480.......490.......500......--.510-.......520-.--.......530......-.540.......550.......560--.......570...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDQ
K
K
Y
S
W
R
K
F
F
Q
L
L
I
SAKPA
N
W
I
-
I
F
C
A
L
F
A
S
V
I
T
T
V
A
G
-
L
V
V
P
---
L
F
T
K
N
L
IDG-F---S
I
---
A
S
------
L
-
D
-----
V
K
M
-
I
-
A
L
I
V
---
L
A
--
F
-
I
L
Q
A
I
TNG
F
S
I
F
L
L
N
Y-M
G
---
Q
----
K
V
V
A
T
I
R
E
R
L
W
K
K
I
V
HL
P
V
S
YFDNT
K
--
T
G
E
M
V
S
R
M
VN
D
T
V
V
V
K
E
L
I
A
D
H
L
P
Q
F
V
T
G
I
I
S
V
V
G
A
I
I
I
L
F
F
MDW
K
M
T
L
I
I
L
V
AV
P
I
T
A
L
V
V
A
P
L
G
Q
K
M
F
K
I
S
KGLQNETANFT
G
S
I
S
-
Q
T
L
-------------
S
E
A
R
L
VKASNAETL
E
T
EAG
H
Q
G
I
N
R
L
F
GFGIR
E
A
K
V
V
A
V
---
L
G
P
L
I
F
F
V
V
-
M
G
-----
V
I
V
G
I
IGYG
G
I
R
V
SAGTM
T
T
G
T
L
I
A
F
L
L
Y
L
F
Q
I
I
V
P
V
T
S
F
A
T
-
F
F
A
Q
L
Q
K
AKG
A
T
E
R
I
A
D
I
L
--------
N
--
E
T
E
E
--
D
FD-----AG------
K
---
K
V-DVSG
K
T
I
R
A
S
----
D
I
S
F
SY--NEG--E--
P
---
I
L
K
HVSFDTKPG
E
V
I
A
F
AGPSGG
G
K
S
T
L
F
A
I
L
E
R
FYQPK---TG
E
I
L
V
GDIPLS--
E
I
SINS
W
R
T
QIGYVSQES
A
M
L
SG-TIR
D
N
L
CYGLD--RE--I
T
--
E
D
E
L
W
N
V
A
K
L
A
YAD
G
F
I
S
EL
P
D
K
M
A
T
E
V
GERGV--KLSGGQ
R
Q
R
I
A
I
A
R
A
F
LRNP
N
I
L
M
LDEATASLD
S
Q
--
S
E
Q
I
-
V
Q
Q
A
L
A
N
L
M--E--GR
T
T
F
V
I
A
H
R
L
S
T
IVN-A
D
Q
I
L
F
I
EHGEITGRGT
H
S
E
L
V
AS--H
P
L
Y
A
S
F
A
E
Q
QLK
6
PsiBlast_PDB
89.51
32%
-115
- C3 -
4Q4A
1
Y288_THEMA
B:
[27-590]
------------
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
---
Y
L
I
G
K
T
I
D
V
V
F
---
V
P
---
R
R
------
F
-
D
-----
L
L
P
-
R
-
Y
M
L
I
---
L
G
T
I
Y
-
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
-
L
S
---
Q
----
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
-
E
D
I
-------------
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
---
L
P
P
L
M
N
M
V
N
-
N
L
-----
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
LE
E
E
K
D
--
D
P
D
-----
A
V
------
E
---
L
R
-
E
V
R
G
E
-
I
E
F
K
----
N
V
W
F
S
Y
--
D
K
K
--
K
--
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
--
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
--
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
--
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
--
T
E
K
S
-
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
--
5
PsiBlast_PDB
88.67
32%
-114
- C3 -
3QF4
1
Y288_THEMA
B:
[27-590]
------------
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
---
Y
L
I
G
K
T
I
D
V
V
F
---
V
P
---
R
R
------
F
-
D
-----
L
L
P
-
R
-
Y
M
L
I
---
L
G
T
I
Y
-
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
-
L
S
---
Q
----
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
-
E
D
I
-------------
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
---
L
P
P
L
M
N
M
V
N
-
N
L
-----
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
LE
E
E
K
D
--
D
P
D
-----
A
V
------
E
---
L
R
-
E
V
R
G
E
-
I
E
F
K
----
N
V
W
F
S
Y
--
D
K
K
--
K
--
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
--
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
--
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
--
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
--
T
E
K
S
-
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
--
7
PsiBlast_PDB
87.99
32%
-111
- C3 -
4Q4H
-
Y288_THEMA
B:
[27-590]
------------
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
---
Y
L
I
G
K
T
I
D
V
V
F
---
V
P
---
R
R
------
F
-
D
-----
L
L
P
-
R
-
Y
M
L
I
---
L
G
T
I
Y
-
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
-
L
S
---
Q
----
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
-
E
D
I
-------------
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
---
L
P
P
L
M
N
M
V
N
-
N
L
-----
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
L
E
E
E
K
D
--
D
P
D
-----
A
V
------
E
---
L
R
-
E
V
R
G
E
-
I
E
F
K
----
N
V
W
F
S
Y
--
D
K
K
--
K
--
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
--
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
--
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
--
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
--
T
E
K
S
-
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
--
8
PsiBlast_PDB
87.21
32%
-112
- C3 -
4Q4J
-
Y288_THEMA
B:
[27-590]
------------
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
---
Y
L
I
G
K
T
I
D
V
V
F
---
V
P
---
R
R
------
F
-
D
-----
L
L
P
-
R
-
Y
M
L
I
---
L
G
T
I
Y
-
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
-
L
S
---
Q
----
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
-
E
D
I
-------------
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
---
L
P
P
L
M
N
M
V
N
-
N
L
-----
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
--------
D
LE
E
E
K
D
--
D
P
D
-----
A
V
------
E
---
L
R
-
E
V
R
G
E
-
I
E
F
K
----
N
V
W
F
S
Y
--
D
K
K
--
K
--
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
--
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
--
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
--
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
--
T
E
K
S
-
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
--
20
PsiBlast_PDB
84.03
30%
-113
- C3 -
4F4C
2
PGP1_CAEEL
A:
[730-1306]
L
E
E
N
N
A
Q
K
T
N
L
F
E
I
L
Y
H
A
R
P
H
A
L
S
-
L
F
I
G
M
S
T
A
---
T
I
G
G
-
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
-
F
---
A
G
---
N
P
------
A
-
D
F----
L
S
Q
-
G
-
H
F
W
A
---
L
M
--
F
-
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
----
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
H
I
G
F
F
D
S
P
Q
NA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
-
S
G
K
I
A
I
E
A
I
-------------
E
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
--
L
N
-----
T
C
A
Y
R
M
G
L
A
L
I
I
T
D
P
P
T
M
Q
P
M
R
V
L
R
-
V
M
Y
A
I
T
I
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
--------
R
--
K
I
S
K
---
I
D
SLSL-
A
G
------
E
---
K
K
-
K
L
Y
G
K
V
I
-
F
K
----
N
V
R
F
A
Y
--
P
E
---
R
--
P
EIE
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
--
T
L
N
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
-
S
I
A
E
N
I
I
Y
G
L
D
P-
S
S
--
V
T
--
M
A
Q
V
E
E
A
A
R
L
A
N
I
H
N
F
I
A
E
L
P
E
G
F
E
T
R
V
G
D
R
G
T
--
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
--
S
E
K
V
-
V
Q
E
A
L
D
R
A
R
--
E
--
G
R
T
C
I
V
I
A
H
R
L
N
T
V
M
N
-
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
--
K
------------
106
HHSearch
83.81
29%
-109
- C3 -
3WMG
6
?
A:
[16-597]
------------
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
-
P
A
F
A
---
I
V
F
G
R
M
F
Q
V
-
F
---
T
K
---
S
K
S
Q
I
E
G
-
E
-
T
-----
W
K
Y
-
S
-
V
G
F
V
---
G
I
--
G
-
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
-
A
S
---
E
----
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
--
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
-
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
-
E
V
F
-------------
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
---
F
F
G
L
S
M
L
V
I
-
F
C
-----
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
-
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
--------
D
--
R
V
P
Q
--
Y
R
R
-----
P
D
PG
A
E
V
V
T
---
Q
P
-
L
V
L
K
Q
G
I
V
F
E
----
N
V
H
F
R
Y
--
P
T
R
MN
V
--
E
---
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
--
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
-
T
I
R
D
N
I
L
Y
G
K
R
--
D
---
A
T
--
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
--
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
--
S
E
A
L
-
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
15
PsiBlast_PDB
83.43
31%
-109
- C3 -
3ZDQ
6
ABCBA_HUMAN
A:
[9-570]
------------
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
-
M
S
A
P
---
F
F
L
G
K
I
I
D
V
I
Y
---
T
N
---
P
T
------
V
-
D
Y
S
D
N
L
T
R
L
-
C
-
L
G
L
S
---
A
V
--
F
-
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
---
Q
----
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
-
E
R
I
-------------
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
--------
F
F
G
A
-
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
-
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
-----------
E
R
E
P
--
K
L
P
-----
F
N
------
E
---
G
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
A
R
--
P
EV
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
--
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
--
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
--
N
E
Y
L
-
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
----------------
14
PsiBlast_PDB
83.42
31%
-111
- C3 -
4AYX
7
ABCBA_HUMAN
A:
[9-570]
------------
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
-
M
S
A
P
---
F
F
L
G
K
I
I
D
V
I
Y
---
T
N
---
P
T
------
V
-
D
Y
S
D
N
L
T
R
L
-
C
-
L
G
L
S
---
A
V
--
F
-
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
---
Q
----
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
-
E
R
I
-------------
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
--------
F
F
G
A
-
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
-
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
-----------
E
R
E
P
--
K
L
P
-----
F
N
------
E
---
G
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
A
R
--
P
EV
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
--
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
--
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
--
N
E
Y
L
-
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
----------------
13
PsiBlast_PDB
82.10
31%
-106
- C3 -
4AYT
8
ABCBA_HUMAN
A:
[9-567]
------------
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
-
M
S
A
P
---
F
F
L
G
K
I
I
D
V
I
Y
---
T
N
---
P
T
------
V
-
D
Y
S
D
N
L
T
R
L
-
C
-
L
G
L
S
---
A
V
--
F
-
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
---
Q
----
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
-
E
R
I
-------------
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
--------
F
F
G
A
-
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
-
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
-----------
E
R
E
P
--
K
L
P
-----
F
N
------
E
---
G
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
A
R
--
P
EV
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
--
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
--
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
--
N
E
Y
L
-
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------
33
PsiBlast_CBE
81.88
32%
-102
- C3 -
2ONJ
4
Y1866_STAAM
B:
[3-569]
--------
K
R
Y
L
Q
F
V
---
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
-
M
L
I
P
---
L
L
I
K
Y
A
I
D
G
-
V
INN
H
A
---
L
T
------
T
-
D
-----
E
K
V
-
H
-
H
L
T
I
AIG
I
A
--
L
-
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
-
L
A
---
Q
WTSN
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
--
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
-
E
R
V
QGISVVKSFAIED
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
---
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
---
I
G
P
I
I
----------------
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
-
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
-------------
D
E
--
D
Y
D
IKNGV
G
A
------
Q
---
P
I
-
E
I
K
Q
G
R
I
D
I
D
----
H
V
S
F
Q
Y
--
N
D
N
--
E
A-
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
--
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
P
--
T
A
---
T
--
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
--
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
--
S
E
S
I
-
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
---------
16
PsiBlast_PDB
81.85
31%
-112
- C3 -
4AYW
3
ABCBA_HUMAN
A:
[40-598]
------------
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
-
M
S
A
P
---
F
F
L
G
K
I
I
D
V
I
Y
---
T
N
---
P
T
------
V
-
D
Y
S
D
N
L
T
R
L
-
C
-
L
G
L
S
---
A
V
--
F
-
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
---
Q
----
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
-
E
R
I
-------------
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
--------
F
F
G
A
-
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
-
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
-----------
E
R
E
P
--
K
L
P
-----
F
N
------
E
---
G
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
A
R
--
P
EV
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
--
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
--
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
--
N
E
Y
L
-
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------
103
HHSearch
81.84
30%
-104
* C3 *
3B60
2
MSBA_SALTY
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
-
T
F
M
L
---
S
L
L
K
P
L
L
D
D
-
G
---
F
G
---
K
T
DRS---
V
-
L
-----
L
W
M
-
P
-
L
V
V
I
---
G
L
--
M
-
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
-
V
S
---
G
----
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
-
Q
M
L
-------------
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
---
S
D
P
I
I
Q
L
I
A
-
S
L
-----
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
-
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
--------
D
--
S
E
Q
E
--
K
D
E
-----
G
K
------
R
---
V
I
-
D
R
A
T
G
D
L
E
F
R
----
N
V
T
F
T
Y
--
P
G
R
E-
V
--
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
R
T
--
E
E
--
Y
S
--
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
--
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
--
S
E
R
A
-
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
10
PsiBlast_PDB
81.78
32%
-100
- C3 -
2HYD
3
Y1866_STAAM
A:
[3-569]
--------
K
R
Y
L
Q
F
V
---
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
-
M
L
I
P
---
L
L
I
K
Y
A
I
D
G
-
V
INN
H
A
---
L
T
------
T
-
D
-----
E
K
V
-
H
-
H
L
T
I
A
I
G
I
A
--
L
-
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
-
L
A
---
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
--
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
-
E
R
V
Q
G
I
S
V
V
K
S
F
AI
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
---
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
---
I
G
P
I
I
----------------
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
-
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
-------------
D
E
--
D
Y
D
IKNGV
G
A
------
Q
---
P
I
-
E
I
K
Q
G
R
I
D
I
D
----
H
V
S
F
Q
Y
--
N
D
N
--
E
A-
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
--
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
P
--
T
A
---
T
--
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
--
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
--
S
E
S
I
-
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
---------
124
Fugue
81.63
30%
-104
- C3 -
3B60
2
MSBA_SALTY
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
-
T
F
M
L
---
S
L
L
K
P
L
L
D
D
-
G
---
F
G
KTD
R
S
------
V
-
L
-----
L
W
M
-
P
-
L
V
V
I
---
G
L
--
M
-
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
-
V
S
---
G
----
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
-
Q
M
L
-------------
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
---
S
D
P
I
I
Q
L
I
A
-
S
L
-----
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
-
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
--------
D
--
S
E
Q
E
--
K
D
E
-----
G
K
------
R
---
V
I
-
D
R
A
T
G
D
L
E
F
R
----
N
V
T
F
T
Y
P-
G
R
E
--
V
--
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
R
T
--
E
E
--
Y
S
--
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
--
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
--
S
E
R
A
-
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
105
HHSearch
81.59
31%
-104
- C3 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
---------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
-
M
S
A
P
---
F
F
L
G
K
I
I
D
V
-
I
---
Y
T
---
N
P
TVDY
S
D
N
-
L
-----
T
R
L
-
C
-
L
G
L
S
---
A
V
--
F
-
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
-
S
G
---
Q
----
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
-
E
R
I
-------------
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
---
F
F
G
A
T
G
L
S
G
-
N
L
-----
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
-
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
--------
E
--
R
E
P
K
--
L
P
F
-----
N
E
------
G
V
I
L
N
E
-
K
S
F
Q
G
A
L
E
F
K
----
N
V
H
F
A
Y
--
P
A
R
PE
V
--
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
A
D
--
D
P
SS
V
T
--
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
--
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
--
N
E
Y
L
-
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P--------------
11
PsiBlast_PDB
81.55
32%
-101
- C3 -
2ONJ
4
Y1866_STAAM
A:
[3-569]
--------
K
R
Y
L
Q
F
V
---
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
-
M
L
I
P
---
L
L
I
K
Y
A
I
D
G
-
V
INN
H
A
---
L
T
------
T
-
D
-----
E
K
V
-
H
-
H
L
T
I
A
I
G
I
A
--
L
-
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
-
L
A
---
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
--
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
-
E
R
V
Q
G
I
S
V
V
K
S
F
AI
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
---
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
---
I
G
P
I
I
----------------
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
-
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
-------------
D
E
--
D
Y
D
IKNGV
G
A
------
Q
---
P
I
-
E
I
K
Q
G
R
I
D
I
D
----
H
V
S
F
Q
Y
--
N
D
N
--
E
A-
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
--
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
P
--
T
A
---
T
--
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
--
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
--
S
E
S
I
-
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
---------
26
PsiBlast_CBE
81.48
31%
-104
- C3 -
3B60
2
MSBA_SALTY
B:
[10-579]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
---
L
L
K
P
L
L
D
D
G
-
F
---
G
K
---
T
D
------
R
-
S
-----
V
L
L
W
M
-
P
L
V
V
---
I
G
--
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
-
V
S
---
G
----
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
-
Q
M
L
-------------
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
---
S
D
P
I
I
Q
L
I
A
-
S
L
-----
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
-
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
-----------
D
S
E
Q
--
E
K
D
-----
E
G
------
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
----
N
V
T
F
T
Y
--
P
G
R
--
E
V-
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
R
T
--
E
E
--
Y
S
--
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
--
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
--
S
E
R
A
-
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
--
4
PsiBlast_PDB
81.01
31%
-104
- C3 -
3B60
2
MSBA_SALTY
A:
[10-579]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
---
L
L
K
P
L
L
D
D
G
-
F
---
G
K
---
T
D
------
R
-
S
-----
V
L
L
W
M
-
P
L
V
V
---
I
G
--
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
-
V
S
---
G
----
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
-
Q
M
L
-------------
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
---
S
D
P
I
I
Q
L
I
A
-
S
L
-----
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
-
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
-----------
D
S
E
Q
--
E
K
D
-----
E
G
------
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
----
N
V
T
F
T
Y
--
P
G
R
--
E
V-
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
R
T
--
E
E
--
Y
S
--
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
--
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
--
S
E
R
A
-
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
--
34
PsiBlast_CBE
80.88
32%
-102
- C3 -
2HYD
3
Y1866_STAAM
B:
[3-569]
--------
K
R
Y
L
Q
F
V
---
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
-
M
L
I
P
---
L
L
I
K
Y
A
I
D
G
-
V
INN
H
A
---
L
T
------
T
-
D
-----
E
K
V
-
H
-
H
L
T
I
AIG
I
A
--
L
-
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
-
L
A
---
Q
WTSN
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
--
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
-
E
R
V
QGISVVKSFAIED
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
---
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
---
I
G
P
I
I
----------------
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
-
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
-------------
D
E
--
D
Y
D
IKNGV
G
A
------
Q
---
P
I
-
E
I
K
Q
G
R
I
D
I
D
----
H
V
S
F
Q
Y
--
N
D
N
--
E
A-
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
--
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
P
--
T
A
---
T
--
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
--
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
--
S
E
S
I
-
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
---------
25
PsiBlast_CBE
80.57
31%
-104
- C3 -
3B60
2
MSBA_SALTY
C:
[10-579]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
---
L
L
K
P
L
L
D
D
G
-
F
---
G
K
---
T
D
------
R
-
S
-----
V
L
L
W
M
-
P
L
V
V
---
I
G
--
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
-
V
S
---
G
----
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
-
Q
M
L
-------------
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
---
S
D
P
I
I
Q
L
I
A
-
S
L
-----
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
-
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
-----------
D
S
E
Q
--
E
K
D
-----
E
G
------
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
----
N
V
T
F
T
Y
--
P
G
R
--
E
V-
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
--
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
A
R
T
--
E
E
--
Y
S
--
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
--
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
--
S
E
R
A
-
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
--
19
PsiBlast_PDB
78.83
30%
-104
- C3 -
4S0F
2
?
A:
[166-723]
------------------
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
-
I
A
G
S
---
F
Y
I
K
F
L
F
D
D
-
L
I
--
K
F
---
E
K
------
L
N
D
-----
L
H
I
-
I
S
A
G
F
A
---
V
I
--
F
-
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
-
L
G
---
M
----
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
--
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
-
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
-
E
S
V
-------------
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
---
L
S
S
L
T
G
I
V
A
G
L
G
-----
G
I
V
-
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
-
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
R
--
E
D
S
D
--
D
F
V
-----
I
S
------
L
---
K
G
-
D
I
E
F
R
---------
N
V
D
F
R
Y
--
G
L
R
--
K
--
P
---
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
--
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
-
T
V
K
E
N
L
C
L
G
-
N
--
E
N
--
V
D
--
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
--
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
--
T
E
N
H
-
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
G
C
Y
F
K
M
W
K
Q
---
23
PsiBlast_CBE
64.12
62%
-98
- C3 -
1MV5
2
LMRA_LACLA
B:
[2-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
----
H
V
D
F
A
Y
--
D
D
S
--
E
--
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
--
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
--
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
--
S
E
S
M
-
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
-
22
PsiBlast_CBE
62.19
62%
-104
- C3 -
1MV5
3
LMRA_LACLA
C:
[2-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
----
H
V
D
F
A
Y
--
D
D
S
--
E
--
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
--
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
--
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
--
S
E
S
M
-
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
-
1
PsiBlast_PDB
61.03
62%
-96
- C3 -
1MV5
3
LMRA_LACLA
A:
[2-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
----
H
V
D
F
A
Y
--
D
D
S
--
E
--
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
--
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
--
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
--
S
E
S
M
-
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
-
21
PsiBlast_CBE
60.53
62%
-104
- C3 -
1MV5
3
D:
[2-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
----
H
V
D
F
A
Y
--
D
D
S
--
E
--
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
--
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
--
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
--
S
E
S
M
-
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
-
110
HHSearch
60.32
62%
-93
- C3 -
1MV5
3
LMRA_LACLA
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
----
H
V
D
F
A
Y
--
D
D
S
--
E
--
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
--
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
--
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
--
S
E
S
M
-
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
--
56
PsiBlast_CBE
59.28
41%
-85
- C3 -
3NH9
3
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
--------
K
--
E
E
T
E
V
K
D
L
P
-----
G
A
------
G
---
P
L
-
R
F
Q
K
G
R
I
E
F
E
----
N
V
H
F
S
Y
--
A
D
G
--
R
--
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
--
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
-----
R
--
V
T
AG
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
--
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
--
N
E
R
A
-
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
--
73
PsiBlast_CBE
57.13
42%
-103
- C3 -
1XEF
3
HLYBP_ECOLX
C:
[6-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
68
PsiBlast_CBE
56.91
42%
-93
- C3 -
2FGJ
2
HLYBP_ECOLX
C:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
114
HHSearch
56.25
42%
-98
- C3 -
2FF7
1
A:
[6-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
I
T
F
R
----
N
I
R
F
R
Y
--
K
P
D
S-
P
--
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
--
G
---
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
75
PsiBlast_CBE
56.19
42%
-100
- C3 -
1XEF
3
HLYBP_ECOLX
A:
[6-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
74
PsiBlast_CBE
55.93
42%
-99
- C3 -
1XEF
3
HLYBP_ECOLX
B:
[6-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
70
PsiBlast_CBE
55.73
42%
-95
- C3 -
2FGJ
2
HLYBP_ECOLX
A:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
71
PsiBlast_CBE
55.62
42%
-98
- C3 -
2FFA
2
A:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
58
PsiBlast_CBE
55.58
42%
-100
- C3 -
2FF7
1
A:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
67
PsiBlast_CBE
55.32
42%
-100
- C3 -
2FGJ
2
D:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
60
PsiBlast_CBE
54.80
42%
-102
- C3 -
2PMK
1
A:
[8-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
72
PsiBlast_CBE
54.73
42%
-98
- C3 -
1XEF
3
D:
[6-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
65
PsiBlast_CBE
54.53
42%
-101
- C3 -
2FFB
1
A:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
69
PsiBlast_CBE
54.44
42%
-96
- C3 -
2FGJ
2
HLYBP_ECOLX
B:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
82
PsiBlast_CBE
54.31
39%
-99
- C3 -
2IXF
4
TAP1_RAT
B:
[17-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
----
D
V
S
F
A
Y
PN
H
P
N
--
V
--
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
--
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
--
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
--
N
Q
L
R
-
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
----
55
PsiBlast_CBE
54.30
41%
-86
- C3 -
3NHA
4
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
--------
K
--
E
E
T
E
VK
D
L
P
-----
G
A
------
G
---
P
L
-
R
F
Q
K
G
R
I
E
F
E
----
N
V
H
F
S
Y
--
A
D
---
R
--
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
--
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
-----
R
--
V
T
AG
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
--
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
--
N
E
R
A
-
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
--
54
PsiBlast_CBE
54.22
41%
-88
- C3 -
3NHB
3
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
--------
K
--
E
E
T
E
V
K
D
L
P
-----
G
A
------
G
---
P
L
-
R
F
Q
K
G
R
I
E
F
E
----
N
V
H
F
S
Y
--
A
D
---
R
--
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
--
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
-----
R
--
V
T
AG
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
--
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
--
N
E
R
A
-
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
--
87
PsiBlast_CBE
53.97
39%
-92
- C3 -
1JJ7
2
A:
[15-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
F
Q
----
D
V
S
F
A
Y
--
P
N
---
R
--
P
DVL
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
--
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
-
S
L
Q
E
N
I
A
Y
G
L
T
--
Q
K
--
P
T
--
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
--
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
--
S
Q
L
Q
-
V
E
Q
L
L
Y
E
S
P
--
E
RY
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
-
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
G
C
Y
---------
83
PsiBlast_CBE
53.92
39%
-99
- C3 -
2IXF
5
TAP1_RAT
A:
[17-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
----
D
V
S
F
A
Y
PN
H
P
N
--
V
--
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
--
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
--
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
--
N
Q
L
R
-
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
----
66
PsiBlast_CBE
53.91
42%
-100
- C3 -
3B5J
1
A:
[8-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
61
PsiBlast_CBE
53.36
42%
-96
- C3 -
2FGK
2
D:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
63
PsiBlast_CBE
52.95
42%
-95
- C3 -
2FGK
2
HLYBP_ECOLX
B:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
62
PsiBlast_CBE
52.00
42%
-93
- C3 -
2FGK
2
HLYBP_ECOLX
C:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
64
PsiBlast_CBE
51.37
42%
-92
- C3 -
2FGK
2
HLYBP_ECOLX
A:
[12-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
--
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
--
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
--
S
E
H
V
-
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
--
52
PsiBlast_CBE
48.37
43%
-97
- C3 -
5DGX
1
?
A:
[23-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
F
A
F
--
G
E
---
H
--
K
---
V
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
--
E
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
-
T
V
Y
N
N
I
A
F
G
-----
E
--
V
S
--
E
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
--
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
-------------------
L
E
S
L
T
--
K
--
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
G
L
Y
T
R
L
Y
Q
S
G
L
Q
109
HHSearch
46.70
30%
-85
- C3 -
3VX4
3
?
A:
[29-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
G
D
I
S
F
E
----
N
L
S
Y
K
Y
--
G
F
G
--
R
--
D
---
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
--
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
D
N
L
V
L
G
A
K
--
E
G
--
T
S
--
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
--
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
--
T
E
K
K
-
I
I
S
N
L
L
Q
M
---
T
--
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
Y
N
L
F
N
----
91
PsiBlast_CBE
45.78
31%
-85
- C3 -
3VX4
3
?
A:
[29-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
F
L
D
G
D
-
I
S
F
E
----
N
L
S
Y
K
Y
--
G
F
G
--
R
--
D
---
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
--
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
D
N
L
V
L
G
A
K
--
E
G
--
T
S
--
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
--
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
--
T
E
K
K
-
I
I
S
N
L
L
Q
M
T
--
E
---
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
---------
102
PsiBlast_CBE
31.73
31%
-73
- C3 -
3C41
3
?
K:
[18-225]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
AK
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
--
K
V
R
K
W
P
R
E
K
---
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
PD
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
MV
G
E
V
L
S
V
M
K
Q
L
A
N
----
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
------------------